id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302459-grs2x26l	Matin, Farhana	A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer	2018-04-27		.txt	text/plain	8311	413	48	In this study we profiled 372 cancer-associated miRNAs in plasma collected before (~60% patients) and after/during commencement of treatment (~40% patients), from age-matched prostate cancer patients and healthy controls, and observed elevated levels of 4 miRNAs miR-4289, miR-326, miR-152-3p and miR-98-5p, which were validated in an independent cohort. Analysis of published miRNA transcriptomic data from clinical samples in the TCGA dataset demonstrated low expression of miR-152-3p in tumour compared to adjacent non-malignant tissues (p = 0.001) (Wilcoxon test, p ≤ 0.05) (Fig. 4) Figure S3) . Similarly, other groups have assessed the diagnostic performance of plasma or serum miRNAs in patients with localised or metastatic prostate cancer, BPH and healthy controls, and in most instances the specificity and sensitivity of the miRNA biomarkers have outperformed the accuracy of the PSA test 23, 28, 29 .	./cache/cord-302459-grs2x26l.txt	./txt/cord-302459-grs2x26l.txt