id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-301695-zl7cjs1k	Wang, Ji	Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana	2019-12-31		.txt	text/plain	3068	165	53	Though NGS had a longer turnaround time (24 hours), it worked well with different sample types (lung tissue, brain tissue and serum from deceased cases and plasma from a severe case) and was more sensitive than nanopore sequencing. The data generated by the Ion Torrent platform were aligned with the genomic database of Histoplasma, and specific reads were found in the serum and mixed brain and lung tissue from the deceased patients and in the plasma from the severe case ( Figure 5 ) [16] . In this case, NGS also identified specific fragments of Histoplasma in all tested samples (lung, brain and blood serum) from the deceased patients, which consolidated the identification of Histoplasma as the causative pathogen, indicating higher detection sensitivity by NGS than nanopore sequencing. We conclude that Histoplasma was the causative pathogen of this disease cluster based on epidemiologic, clinical, pathological and nucleic acid evidence.	./cache/cord-301695-zl7cjs1k.txt	./txt/cord-301695-zl7cjs1k.txt