id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292281-fui9all6	Pratelli, A.	High‐cell‐passage canine coronavirus vaccine providing sterilising immunity	2007-09-14		.txt	text/plain	3532	177	54	Clinical Significance: This study showed the efficacy of a high‐cell‐passage canine coronavirus vaccine in preventing infection of dogs by virulent virus and, specifically, its ability to induce sterilising immunity. Faecal samples collected from the vaccinated and control dogs were tested by virus isolation and PCR assays. After challenge with field strain 144/ 01, the vaccinated dogs did not develop clinical signs, and virus isolation and PCR did not detect viral shedding. In a recent study, it was found that the inactivated vaccine had poor efficacy in reducing faecal shedding of CCoV following infection with a field strain of the virus (Pratelli and others 2003b) . After challenge at 14 dpsv, protection from CCoV infection was complete because no viral shedding was observed by either virus isolation or PCR tests. The present study has shown the efficacy of a high-cell-passage CCoV vaccine in preventing infection of dogs by virulent virus and, specifically, its ability to induce sterilising immunity.	./cache/cord-292281-fui9all6.txt	./txt/cord-292281-fui9all6.txt