id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287447-5lzzobl3	Keyaerts, Els	In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine	2004-10-08		.txt	text/plain	2159	130	53	Abstract We report on chloroquine, a 4-amino-quinoline, as an effective inhibitor of the replication of the severe acute respiratory syndrome coronavirus (SARS-CoV) in vitro. Glycyrrhizin (an active component of liquorice roots), niclosamide (an antihelminthic drug), nelfinavir (a human immunodeficiency deficiency virus (HIV) protease inhibitor), and SNAP (a nitric oxide donor) were reported to have an antiviral effect against SARS-CoV [12] [13] [14] [15] . In this study we report the in vitro antiviral activity of chloroquine against SARS-CoV Frankfurt 1 strain infection. The IC 50 of chloroquine inhibition of SARS-CoV replication in Vero E6 cells, 8.8 lM, is below (1000-fold) the plasma concentrations of chloroquine that are reached in human plasma, following treatment with chloroquine (for acute malaria) at a dose of 25 mg/kg over three days [27] . Our results show that chloroquine inhibits the replication of SARS-CoV in Vero E6 cells.	./cache/cord-287447-5lzzobl3.txt	./txt/cord-287447-5lzzobl3.txt