id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260231-vayxg23a	Hsien Koh, Tse	Epidemiology of Clostridium difficile infection in a large teaching hospital in Singapore	2007-08-31		.txt	text/plain	3314	224	58	Summary Aims We undertook this study to define the incidence of toxigenic Clostridium difficile in our hospital and to characterise the isolates. Detection of tcdA and tcdB genes was carried out for A2B+ strains by polymerase chain reaction (PCR).The minimum inhibitory concentrations (MICs) of metronidazole, vancomycin and clindamycin for all isolates were tested using the Etest. All unformed stool from SGH inpatients sent to the Department of Pathology from 1 October 2002 to 28 February 2003 was tested for the presence of TcdA and TcdB using the Premier Toxin A and B enzyme immunoassay (EIA) kit (Meridian Diagnostics, USA) following the manufacturer's instructions. Combining the numbers of toxigenic strains and culture negative/direct toxin positive specimens, the incidence of CDAD was 3.2 cases per 1000 admissions or discharges and 53.8 cases per 100 000 patient days. Clindamycin resistant strains of Clostridium difficile isolated from cases of C.	./cache/cord-260231-vayxg23a.txt	./txt/cord-260231-vayxg23a.txt