id author title date pages extension mime words sentences flesch summary cache txt cord-258819-4boe6t1v Waller, Joseph V. The Limited Sensitivity of Chest Computed Tomography Relative to Reverse Transcription Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Systematic Review on COVID-19 Diagnostics 2020-06-16 .txt text/plain 4443 226 49 title: The Limited Sensitivity of Chest Computed Tomography Relative to Reverse Transcription Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Systematic Review on COVID-19 Diagnostics OBJECTIVES: Several studies suggest the sensitivity of chest computed tomography (CT) is far greater than that of reverse transcription polymerase chain reaction (RT-PCR) in diagnosing COVID-19 patients, and therefore, CT should be included as a primary diagnostic tool. The quality assessment tool QUADAS-2 was used to stratify studies according to their risk of bias, and exclusion criteria included not providing the information deemed relevant for such a stratification, such as not indicating if the patients were symptomatic or asymptomatic, or identifying the source of the specimen for the reference standard, RT-PCR (eg, nasal, oropharyngeal, etc). A recent study by Li and colleagues 18 tested a cohort of patients assumed to have SARS-CoV-2 infection owing to CT findings consistent with a viral pneumonia and reported an RT-PCR sensitivity of 27.5% (n = 610). ./cache/cord-258819-4boe6t1v.txt ./txt/cord-258819-4boe6t1v.txt