id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258724-1qhen1bj	Young, Barnaby E	Viral dynamics and immune correlates of COVID-19 disease severity	2020-08-28		.txt	text/plain	3612	253	52	METHODS: We evaluated these characteristics and established their association with clinical severity in a prospective observational cohort study of 100 patients with PCR-confirmed SARS-CoV-2 infection (mean age 46 years, 56% male, 38% with comorbidities). In this multi-pronged study, we describe the serologic evolution, inflammatory response and pattern of viral shedding and viability in patients with virologically confirmed COVID-19 in Singapore, and analyse the contributions these make to severe infections. Serum collected during the acute and convalescent phases of infection were tested for SARS-CoV-2 receptor binding domain specific IgM and IgG using capture ELISA (details in Supplementary Appendix). The central role of the immune response to SARS-CoV-2 in COVID-19 was evident from the strong correlation between disease severity and levels of IgG/IgM and inflammatory immune mediators in our cohort. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study	./cache/cord-258724-1qhen1bj.txt	./txt/cord-258724-1qhen1bj.txt