id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254101-613aftc1	Wang, Ping	Establishment of a transgenic mouse model with liver-specific expression of secretory immunoglobulin D	2012-04-14		.txt	text/plain	4387	239	60	In this study, we generated by fusion PCR a vector to express high levels of chimeric secretory IgD (csIgD) specifically in the liver. Hyperimmunoglobulinemia D syndrome (HIDS), also called receptor-associated periodic syndrome or etiocholanolone fever, is characterized by high serum levels of immunoglobulin D (IgD) and recurrent febrile attacks, and may also include arthritis, lymphadenopathy, hepatosplenomegaly, and skin rash [1-3]. The resulting plasmids, designated en-pAlb-csIgD-H and en-pAlb-cKappa, were under control of the mouse Alb regulatory sequences to direct gene expression specifically in the liver. This indicates that the inflammation in the transgenic mice is caused by increased sIgD rather than by Mvk mutation. Skin ulcers in transgenic mice with high expression of sIgD may be caused by excessive immune activation. An albumin enhancer located 10-kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice High level expression of a functional human/mouse chimeric anti-CD20 monoclonal antibody in milk of transgenic mice	./cache/cord-254101-613aftc1.txt	./txt/cord-254101-613aftc1.txt