id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254064-qxgpehuy	Chacko, J.	Hydroxychloroquine in COVID-19: A systematic review and meta-analysis	2020-05-19		.txt	text/plain	4034	289	57	In spite of several observational studies and a few randomized controlled trials, the effect of hydroxychloroquine on patients with COVID 19 infection remains unclear. Conclusions Our meta-analysis does not suggest improvement in clinical progression, mortality, or viral clearance by RT PCR among patients with COVID 19 infection who are treated with hydroxychloroquine. Hence, we performed a systematic review and meta-analysis of available controlled studies to evaluate the safety and efficacy of hydroxychloroquine in the treatment of COVID-19 infection. Studies were considered eligible if they included patients who received hydroxychloroquine alone or in combination with other specific treatment modalities for COVID-19 infection and were compared with a control group. Data on at least one of the following outcomes had to be available for inclusion in the meta-analysis: (i) mortality, (ii) clinical progress, (iii) results of the reverse transcription-polymerase chain reaction (RT-PCR) test after the commencement of treatment, (iv) changes on computed tomography (CT) imaging of the chest, and (iv) adverse clinical events.	./cache/cord-254064-qxgpehuy.txt	./txt/cord-254064-qxgpehuy.txt