id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-158252-l43ztxsl	Pawlowski, Colin	Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures	2020-05-21		.txt	text/plain	6126	221	35	We found that compared to COVIDneg at the time of clinical presentation and diagnostic testing, COVIDpos patients tended to have higher plasma fibrinogen levels and similarly low platelet counts, with approximately 25% of patients in both cohorts showing outright thrombocytopenia. To this end, we instituted a holistic data science platform across an academic health care system that enables machine intelligence to augment the curation of phenotypes and outcomes from 15.2 million EHR clinical notes and associated 3 million lab tests from 1,192 COVID-19positive (COVIDpos) and 47,344 confirmed COVID-19-negative (COVIDneg) patients over a retrospectively defined 2-month observation period straddling the date of the PCR test (see Methods). Conversely, platelet counts were lower in the COVIDpos cohort at the time of clinical presentation but tended to increase over the subsequent 10 days to levels significantly higher than those in COVIDneg patients (Cohen's D = 0.361, BH-adjusted Mann-Whitney p-value = 0.008, Table 2, Figure 2B ).	./cache/cord-158252-l43ztxsl.txt	./txt/cord-158252-l43ztxsl.txt