id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-024080-eh3ztsv5	Dheda, Keertan	Diagnosis of COVID-19: Considerations, Controversies and Challenges in South Africa	2020-04-17		.txt	text/plain	3953	214	44	Recent data from infections in special contexts such as cruise liners (9) and in close contacts of COVID-19 patients (10) have demonstrated that SARS-CoV-2-specific RT-PCR may be positive in the early phase of the disease, and that viral shedding in the asymptomatic phase and in the early prodromal phase can be considerable. (19) This false negativity phenomenon may be due to several factors, including a low viral load below the detection limit of the assay, low sample volume or cellular mass during acquisition, sampling location (upper versus lower respiratory tract), sample degradation during transport or storage, sample processing methodology and the timing of sampling in relation to the stage of the disease (RT-PCR positivity may progressively increase during the course of the disease). In patients with more severe diseases, including those with lower respiratory tract infection, but also in individuals with mild disease, high viral loads can be detected often for several days after the resolution of symptoms.	./cache/cord-024080-eh3ztsv5.txt	./txt/cord-024080-eh3ztsv5.txt