id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017767-zj1h5ixf	Shieh, Wun-Ju	Advanced Pathology Techniques for Detecting Emerging Infectious Disease Pathogens	2012-04-05		.txt	text/plain	5249	247	35	Although general practice of pathology is largely oriented toward diagnosis of neoplastic diseases, pathologists have been increasingly called upon to make diagnoses from tissue samples collected by cytology, biopsy, and autopsy procedures in response to the challenge of emerging infections [1] [2] [3] [4] . Immunolocalization of antigens by IHC provides histomorphologic correlation between the infectious pathogen and host tissue responses, which is not only crucial for diagnosis but also important to study the pathogenesis of those emerging infections [ 19, 21, 39, 40 ] . PCR ampli fi cation undoubtedly is the most sensitive method available to detect microbial organisms in tissue specimens and has become a common practice in many pathology laboratories. These differential 16S rRNA gene PCR assays provide more speci fi c information regarding the bacteria identity and are very useful for detecting bacterial pathogens in tissue samples in conjunction with histopathologic evaluation, special stains, and IHC.	./cache/cord-017767-zj1h5ixf.txt	./txt/cord-017767-zj1h5ixf.txt