id author title date pages extension mime words sentences flesch summary cache txt cord-010235-hu6o1ggc Atmar, Robert L. Nonculturable agents of viral gastroenteritis 1997-12-01 .txt text/plain 3989 190 43 (3) provided the first clear demonstration of the causal relationship between a virus (Norwalk virus [NV] ) and gastroenteritis by using immune electron microscopy (IEM) to detect the presence of viral particles in the stools of individuals from an epidemic outbreak of gastroenteritis. This article describes the structure and genome organization of the human caliciviruses that cause gastroenteritis, the clinical and epidemiologic features of these viruses, and new methods for the laboratory diagnosis of infection with these viruses. The inability to cultivate the HuCVs and establish neutralization assays has prevented the definition of specific serotypes; however, at least five different serotypes are thought to exist based on early human cross-challenge studies and comparisons of the IEM and enzyme-linked immunosorbent assay (ELISA) reactivities of several prototype virus strains. ./cache/cord-010235-hu6o1ggc.txt ./txt/cord-010235-hu6o1ggc.txt