id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275779-ocbygkyb	Ye, Zi-Wei	Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice	2017-03-21		.txt	text/plain	5425	253	42	title: Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice Engaging the antibody-dependent cell-mediated cytotoxicity (ADCC) for killing of virus-infected cells and secretion of antiviral cytokines and chemokines was incorporated as one of the important features in the design of universal influenza vaccines. In this study, we determined the ADCC and antiviral activities of two putative ADCC epitopes, designated E1 and E2, on the HA head of a pandemic H1N1 influenza virus in vitro and in a lethal mouse model. The phenotype was potentially due to an exaggerated inflammatory cell infiltration triggered by ADCC, as an upregulated release of cytotoxic granules (perforin) was observed in the lung tissue of E1-vaccinated mice after H1N1 influenza virus challenge. While the antiviral efficacy provided by the stalk-specific ADCC antibodies has been confirmed (12) , our data raised concerns on the side effect of certain HA head epitopes in devising a universal influenza vaccine.	./cache/cord-275779-ocbygkyb.txt	./txt/cord-275779-ocbygkyb.txt