id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001732-4eyn7pjq	Riede, O	Preclinical safety and tolerability of a repeatedly administered human leishmaniasis DNA vaccine	2015-04-30		.txt	text/plain	6339	336	49	Evaluation of single-dose and repeated-dose toxicity of the vaccine candidate after i.d. administration to naive, non-infected mice did not reveal any safety concerns. To assess toxicity of LEISHDNAVAX in naive mice, sterile phosphate-buffered saline (PBS, placebo) and ascending doses of the vaccine were injected either once or five times in weekly intervals (Table 1) . Twenty-four hour after single or repeated injection, MIDGE-Th1 vector DNA was detected in almost all organs and tissues examined, suggesting that it was distributed systemically, most likely via the lymphatic system and the blood stream. Groups of 10 BALB/c mice (5 male, 5 female) were immunized i.d. at the tail base five times in weekly intervals with either PBS or LEISHDNAVAX (10, 50 or 100 μg per dose). In summary, we have shown here that LEISHDNAVAX, a novel DNA vaccine candidate against leishmaniasis is safe and well tolerated in both naive and Leishmania-infected mice.	./cache/cord-001732-4eyn7pjq.txt	./txt/cord-001732-4eyn7pjq.txt