key: cord-290401-t87i3exo
authors: Bassetti, Matteo; Kollef, Marin H.; Poulakou, Garyphallia
title: Principles of antimicrobial stewardship for bacterial and fungal infections in ICU
date: 2017-09-12
journal: Intensive Care Med
DOI: 10.1007/s00134-017-4922-x
sha: 
doc_id: 290401
cord_uid: t87i3exo

nan

Enterobacteriaceae [3] . Antimicrobial use is a key determinant in the selection of resistant bacteria, whereby increasing daily cumulative exposure, especially for carbapenems, increases the likelihood of intestinal carriage of MDROs [3] . The rapid evolution of antibiotic resistance impedes efforts to insure that initial appropriate antibiotic therapy is delivered to critically ill infected patients. The rising rates of antibiotic resistance have likely contributed to the increase in observed mortality attributed to antibiotic-resistant bacteria, despite the overall reduction in deaths ascribed to infectious diseases in the last century [4] . Acinetobacter baumannii and Pseudomonas aeruginosa represent two of the most important MDROs due to the extent of their antimicrobial resistance, intrinsic virulence, especially for Pseudomonas, and ability to establish themselves within hospital environments such as ICUs and to infect immune suppressed hosts [1, 5] . Indeed, a recent European task force now recommends the empiric use of polymixin or colistin as part of the empiric antimicrobial regimen when infection with A. baumannii is suspected due to the high rates of carbapenem resistance in this pathogen [5] . An important contributor to the escalating rates of infection with these MDROs, especially in Europe and North America, has been population migration from the Middle East and other parts of Asia and Africa. Similarly, the movement of individuals across borders is also recognized as an important source of spread of other emerging infections such as Dengue fever, Zika virus, and Middle East respiratory syndrome coronavirus [6] . Reducing the unnecessary use of antibiotics is seen as a pivotal strategy for curtailing the further emergence and spread of MDROs [7] . Figure 1 provides a summary of the strategy of antimicrobial de-escalation 

There is accumulating recent evidence that rates of catheter-related infections (CRI) can be substantially reduced towards zero with the correct application of care bundles. As recently summarized in Intensive Care Medicine, the cornerstone of prevention relies on the correct skin preparation [8, 9] . Alcohol seems mandatory in antisepsis solutions due to its rapid activity; chlorhexidine gluconate ensures a prolonged bactericidal effect. There are actually some important certainties/recommendations on prevention of CRI like: (1) application of sterile 2% CHG-alcohol to disinfect the skin prior to insertion of a vascular catheter, (2) no need for cleaning the skin with soap or detergent before antiseptic application when it is not obviously dirty or contaminated, (3 )rinsing with sterile water is not recommended after antiseptic application, (4) single-use vials of disinfectant solutions are preferable to multiple-use bottles, (5) daily evaluation of the necessity of retaining central line(s) and removal if they are clinically no longer necessary, (6) non-adherent, soiled, or moistened dressings should be promply replaced, (7) a subclavian site of insertion is preferable unless otherwise contraindicated, (8) full barrier precautions should be used at insertion, (9) hand hygiene with alcoholic solution is mandatory before every manipulation, and (10) every unit should adopt a written protocol for catheter insertion and maintenance. Certainly, there is room for improvement, with behavioral approaches requiring welldesigned multinational trials. However, mortality and CRI rates were not reduced in a prospective randomized controlled study from Brazil employing a behavioral approach for retention or withdrawal of central lines; the rather short evaluation period might have contributed to this. Nevertheless, the feedback from administrators and caregivers was positive, prompting universal adoption of the program after the experimental period of 6 months [10] . Transparent antimicrobial dressings, being significantly more efficacious in preventing CRBSIs when compared to the reference dressings and the use of sterile 2% CHG/70% isopropyl alcohol for skin antisepsis represent new standards of care [8, 9, 11] .

Source control, recommended within 12 h from patient's admission, includes primarily actions taken in the process of care to control the foci of infection. It is gaining importance as a pivotal measure to improve patients' outcomes, particularly in intra-abdominal, skin and soft tissue, implant-associated infections and CRI. In the Edusepsis study conducted in Spanish ICUs, patients who underwent source control were older, had a greater prevalence of shock, major organ dysfunction, bacteremia, inflammatory markers, lactic academia and worse compliance with the resuscitation bundle compared with those who did not undergo source control [12] . The source control group had lower crude ICU and hospital mortality even after adjustment for confounding factors. Source control performed after 12 h was not associated with higher mortality, implying that in high-risk patients even beyond the 12-h timeframe from admission, it may contribute to improved outcomes [5] . In another Spanish retrospective cohort of intraabdominal candidiasis (IAC), source control along with early antifungal treatment was associated with improved survival in both ICU and surgical wards, standing out as the main goal for decreasing mortality of IAC episodes inside and outside the ICU [13] .

Invasive candidiasis (IC) comprises both bloodstream and other deep-seated invasive infections due to Candida species and represents a major cause of morbidity and mortality, which remains near 40% in most series. Over the past decades, incidence of IC has shown progressively increasing or stable rates in most regions [14] [15] [16] , probably due to the growing complexity of surgical procedures, the presence of patient populations at higher risk of infection, and the changes in patient demographic characteristics [14] . Attributable mortality around 10% has been reported in several studies [16] , while a recent well-designed study conducted in India has reported rates around 20% [14] . Infection-related morbidity and mortality associated with IC are in part associated with the critical illness itself, but they may also be attributed to suboptimal diagnostic tools. Standard mycological conventional blood culture is a gold standard, but may fail to diagnose IC in up to 25-50%, whereas time to positivity for yeast and species identification can take several days from the time the blood culture is drawn, depending on the implicated Candida species [16] . Unless antifungal therapy is promptly initiated by the confirmation of IC, effective antifungal therapy may be further delayed. Numerous studies have demonstrated that the delay of initiation of antifungal therapy was associated with significant increases in both in-hospital mortality and the cost of care for patients with IC [16] .

While candidemia episodes are easier to recognize and diagnose compared to deep-seated candidiasis, current guidelines mainly focus on the management of candidemia, while trials on IAC are lacking [15] . Risk factors for IAC include recent surgery, necrotizing pancreatitis, and anastomotic leaks. Empirical antifungal treatment with echinocandins or lipid-formulation of amphotericin B should be considered in the critically ill or in patients with previous exposure to azoles and risk factors for Candida spp. infection. Despite the lack of randomized trials, antifungal therapy for patients with complicated intra-abdominal infection is recommended when Candida spp. is grown from cultures [15] .

In severe abdominal conditions in non-neutropenic critically ill patients, high 1,3--d-Glucan levels combined with Candida albicans germ tube antibodies may help clinicians in discriminating Candida spp. colonization from IC [17] .

Source control has shown to be an important determinant of outcome for patients with candidemia and IAC [14] [15] [16] . Based on expert guidelines and previous studies, central venous catheter withdrawal should be attempted and any identified collection should be rapidly and appropriately drained.

In cases of IC, treatment should be given immediately, but thereafter it would be important to step down early to a triazole. De-escalation from an echinocandin to intravenous or oral fluconazole should be encouraged when the patient is clinically stable and the isolated strain is susceptible. The exact timing for shifting to fluconazole is not well established and may vary, depending on patient-and pathogen-related factors. The safety of deescalation (within 5 days) in the case of proven or probable IC has been recently suggested for non-neutropenic patients treated in the ICU, since it was not associated with increased mortality and led to a subsequent and significant decrease in the antifungal consumption [18] .

The most remarkable rules for developing antifungal stewardship program targeting antifungal treatments bundles are reported in the Electronic Supplement Material.

Preventive and therapeutic strategies in critically ill patients with highly resistant bacteria

The timing of early antibiotics and hospital mortality in sepsis

Understanding resistance

Infectious disease mortality trends in the United States

Task force on management and prevention of Acinetobacter baumannii infections in the ICU

Planet's population on the move, infections on the rise

Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric)

What's new in catheter-related infection: skin cleansing and skin antisepsis

What's new in skin antisepsis for short-term intravascular catheters: new data to address old problems?

Skin antisepsis with chlorhexidinealcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheterrelated infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial

Effect of a quality improvement intervention with daily round checklists, goal setting, and clinician prompting on mortality of critically ill patients: a randomized clinical trial

Edusepsis Study Group (2017) Impact of source control in patients with severe sepsis and septic shock

Association between source control and mortality in 258 patients with intra-abdominal candidiasis: a retrospective multi-centric analysis comparing intensive care versus surgical wards in Spain

) Incidence, characteristics and outcome of ICUacquired candidemia in India

A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality

Intensive care medicine research agenda on invasive fungal infection in critically ill patients

) -d-Glucan and Candida albicans germ tube antibody in ICU patients with invasive candidiasis

Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data