key: cord-263294-9r84f19u authors: Chen, Siyu; Liao, E.; Cao, Dongmei; Gao, Ying; Sun, Guoqiang; Shao, Yong title: Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia date: 2020-04-10 journal: J Med Virol DOI: 10.1002/jmv.25789 sha: doc_id: 263294 cord_uid: 9r84f19u The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID‐19) and provide help for clinical prevention and treatment. All five cases of pregnant women confirmed COVID‐19 were collected among patients who admitted to the Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020. All patients, aging from 25 to 31 years old, had the gestational week from 38th weeks to 41st weeks. All pregnant women did not have an antepartum fever but developed a low‐grade fever (37.5℃‐38.5℃) within 24 hours after delivery. All patients had normal liver and renal function, two patients had elevated plasma levels of the myocardial enzyme. Unusual chest imaging manifestations, featured with ground‐grass opacity, were frequently observed in bilateral (three cases) or unilateral lobe (two cases) by computed tomography (CT) scan. All labors smoothly processed, the Apgar scores were 10 points 1 and 5 minutes after delivery, no complications were observed in the newborn. Pregnancy and perinatal outcomes of patients with COVID‐19 should receive more attention. It is probable that pregnant women diagnosed with COVID‐19 have no fever before delivery. Their primary initial manifestations were merely low‐grade postpartum fever or mild respiratory symptoms. Therefore, the protective measures are necessary on admission; the instant CT scan and real‐time reverse‐transcriptase polymerase‐chain‐reaction assay should be helpful in early diagnosis and avoid cross‐infection on the occasion that patients have fever and other respiratory signs. All pregnant women did not have an antepartum fever but developed a low-grade fever (37.5℃-38.5℃) within 24 hours after delivery. All patients had normal liver and renal function, two patients had elevated plasma levels of the myocardial enzyme. Unusual chest imaging manifestations, featured with ground-grass opacity, were frequently observed in bilateral (three cases) or unilateral lobe (two cases) by computed tomography (CT) scan. All labors smoothly processed, the Apgar scores were 10 points 1 and 5 minutes after delivery, no complications were observed in the newborn. Pregnancy and perinatal outcomes of patients with COVID-19 should receive more attention. It is probable that pregnant women diagnosed with COVID-19 have no fever before delivery. Their primary initial manifestations were merely low-grade postpartum fever or mild respiratory symptoms. Therefore, the protective measures are necessary on admission; the instant CT scan and real-time reverse-transcriptase polymerase-chain-reaction assay should be helpful in early diagnosis and avoid cross-infection on the occasion that patients have fever and other respiratory signs. other countries, is causing a global health problem. 1 Our study collected a total of five pregnant women with COVID-19, who were hospitalized for regular delivery in Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020 (Table 1 ). All patients were regularly given a prenatal routine examination that started from the first trimester. Ultrasound examination and fetal heart monitoring were offered regularly before delivery, no symptoms of viral pneumonia were observed. On latest admission, all patients received routine fetal heart monitoring and laboratory examinations including complete blood count, blood chemistry, coagulation test, liver and renal function, electrolytes, C-reactive protein, procalcitonin, lactate dehydrogenase, and creatine kinase. The delivery strategy is determined according to the pregnant women's general situation. Apgar scoring and nursing was routinely given for the newborn after delivery. According to the demographic data of five patients (Table 1) Cough Laboratory findings showed ( Table 2 ) that in the early stage of the disease, the count of WBCs in all patients was normal, and two patients developed an increased WBC count 24 hours after the symptom onset. The WBC counts of patient 5 were always abnormally high during hospital admission. C-reactive protein levels increased in all patients but except patient 4, particularly in patient 5 who had a substantial increase The perinatal outcomes and newborns are described in Table 3 . A study that analyzed 12 cases of pregnant women with SARS in 2004, Hong Kong, found that pregnant women with SARS were associated with high morbidity and mortality. 6 were not recommended to use ribavirin because of its risk to lead to fetal deformities. 15 New drugs for the treatment of COVID-19 are still being tested in clinical trials, 16 The 2019-nCoV Outbreak Joint Field Epidemiology Investigation Team QL. 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Committee Opinion No. 656: guidelines for diagnostic imaging during pregnancy and lactation Impact of Middle East respiratory syndrome coronavirus (MERS-CoV) on pregnancy and perinatal outcome Clinical characteristics of coronavirus disease 2019 in China Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia The authors declare that there are no conflict of interests. The corresponding author GS and YS developed the study concept and design, critically reviewed the data and decided the content of the manuscript. All other authors acquired and/or analyzed data, performed the statistical analysis and/or provided technical or material support and/or wrote and/or critically reviewed the manuscript. Authors SC, EL and DC contributed equally to this study.All authors finally decided on the content of the manuscript. http://orcid.org/0000-0002-5734-2015