id author title date pages extension mime words sentences flesch summary cache txt cord-355003-1o2midnh Wang, Min Convalescent plasma therapy in critically ill coronavirus disease 2019 patients with persistently positive nucleic acid test, case series report 2020-09-04 .txt text/plain 1978 132 56 title: Convalescent plasma therapy in critically ill coronavirus disease 2019 patients with persistently positive nucleic acid test, case series report CONCLUSION: The time of initiating the CPT may be an important factor affecting its efficacy, and its therapeutic effect in the treatment of COVID-19, in the late stage, is limited. [2] However, convalescent plasma therapy (CPT) has been successfully used to treat the severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and H1N1 influenza, and has been found to be an effective measure in reducing the mortality amongst the critically ill patients. Based on the clinical practice, in this report, 5 critically ill COVID-19 patients with persistently positive nucleic acid test, for more than 30 days, were treated with CP, in the middle and late stages of the disease. A study evaluating the efficacy of CPT in influenza A (H1N1, 2009) reported that CPT could result in reduced respiratory viral load and mortality in severely ill patients, and dampen the cytokine response. ./cache/cord-355003-1o2midnh.txt ./txt/cord-355003-1o2midnh.txt