id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350923-532lnnll	Ramalho, Renata	Immunometabolism: new insights and lessons from antigen-directed cellular immune responses	2020-06-09		.txt	text/plain	17495	878	30	That said, different immune cell functions are, in fact, associated with distinct metabolic configurations: resting immune cells utilize energetically efficient processes such as the tricarboxylic acid (TCA), linked to the generation of ATP via oxidative phosphorylation (OXPHOS), whereas activated cells prefer glycolysis to generate adequate levels of energy storage to support survival and produce numerous biosynthetic intermediates to allow for cellular growth and proliferation [14] . Pertaining to arginine metabolism and immune cells, arginase-1 is responsible for the breakdown of arginine to ornithine and plays a role in the immune function regulation of activated T-cells through depletion of arginine in the local microenvironment (as controlling arginine bioavailability leads to control of nitric oxide production), which has been described in experimental models of cancer and tuberculosis [56] [57] [58] .	./cache/cord-350923-532lnnll.txt	./txt/cord-350923-532lnnll.txt