id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328113-eczjjc2v	D’Alessandro, Angelo	Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level	2020-07-30		.txt	text/plain	4662	237	40	Subjects seen at Columbia University Irving Medical Center/New York−Presbyterian Hospital included 33 COVID-19-positive patients, as determined by SARS-CoV-2 nucleic acid testing of nasopharyngeal swabs; in this group, the severity of the disease was inferred from serum levels of IL-6, which were determined by CLIAcertified ELISA-based measurements. Sera of COVID-19 patients, especially those with IL-6 levels >10 pg/mL, contained increased levels of multiple proteins in the acute phase response that is initiated by IL-6specifically components of the coagulation and complement cascades (top enriched pathway, p-value: 1.6 × 10 −31 ; Figure 2 ). Other RBC-derived proteins (i.e., band 3, anion exchanger 1 (AE1; the most abundant RBC membrane protein), peroxiredoxins 2 and 6, catalase, and Journal of Proteome Research pubs.acs.org/jpr Article biliverdin reductase B) correlated significantly with HBA and HBB levels, despite not reaching significance when compared to COVID-19-negative subjects, suggesting that minimal hemolysis was present in a subset of the most severely ill patients in our study ( Figure 4A ), perhaps due to mechanical ventilation or other iatrogenic interventions−including the sample collection protocol adopted in this study.	./cache/cord-328113-eczjjc2v.txt	./txt/cord-328113-eczjjc2v.txt