id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326984-o27rp468	CHIEN, Jung‐Yien	Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome	2006-10-16		.txt	text/plain	3569	202	53	To improve understanding of the immuno‐pathological processes involved in lung injury associated with SARS, the temporal changes in cytokine/chemokine profiles in the sera of SARS patients were compared with those of patients with community‐acquired pneumonia (CAP), according to the degree of lung involvement. 5 In order to improve the understanding of the immuno-pathogenesis of SARS, an analysis of the dynamic changes in cytokine/chemokine profiles was undertaken in SARS patients who initially had a normal CXR, but who later progressed to typical manifestations of lung involvement. In this study, we investigated 14 SARS patients with initially normal CXR and 24 patients with non-SARS CAP, to clarify the association between temporal changes in cytokine/chemokine profiles and the severity of lung involvement during SARS. 15, 17, 18 Similar to the current study, many of the 'classic' cytokines mediating inflammation in acute lung injury, 18 such as TNF-α and IFN-γ, were not reported to be significantly increased during SARS.	./cache/cord-326984-o27rp468.txt	./txt/cord-326984-o27rp468.txt