id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314070-8qz23nn4	Gubbi, Sriram	Catecholamine physiology and its implications in patients with COVID-19	2020-10-28		.txt	text/plain	5313	296	31	The risk factors for severe COVID-19 are diverse, yet closely resemble the clinical manifestations of catecholamine excess states (eg, hypertension, cardiovascular disease, immune dysregulation, and hyperglycaemia), suggesting a potentially common basis for disease. 6 Consequently, catecholamine excess states such as PPGL can cause substantial dysregulation of physiological systems, and lead to pronounced changes in pulmonary (vasoplegia), coronary (myocardial infarction), cerebro vascular (stroke), and remaining systemic vascular tone (hypertension), as well as myocardial disease (cardio myopathies), tachyarrhythmias (benign and fatal), hyper coagulability (thromboem bolism), immune dysreg u lation (cytokine storm), and diabetogenic states; these outcomes are the same as the risk factors that lead to adverse outcomes from COVID-19. 19 Increased concentrations of these cytokines and their downstream acute phase reactants (eg, ferritin) have been associated with a higher likelihood of severe disease and mortality in patients with 20 Catecholamines augment the production of IL-6, IL-10, and other cytokines through a self-amplifying feed-forward loop within myeloid cells, an effect mediated through α1-adrenoceptors.	./cache/cord-314070-8qz23nn4.txt	./txt/cord-314070-8qz23nn4.txt