id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309441-obojsf04	Pirau, Letitia	Case Series: Evidence of Borderzone Ischemia in Critically-Ill COVID-19 Patients Who “Do Not Wake Up”	2020-09-23		.txt	text/plain	2739	143	35	We conclude that critically-ill COVID-19 patients with prolonged coma following sedation discontinuation may demonstrate imaging features of ischemic injury in borderzone regions despite the absence of documented sustained hypotension or hypoxia. In this report, we describe the clinical course, radiological findings, and outcome of two such COVID-19 patients, initially intubated for ARDS while neurologically intact, who demonstrated prolonged unresponsiveness following discontinuation of sedation, with evidence of borderzone ischemia on Magnetic Resonance Imaging (MRI) of the brain. An MRI of the brain scan performed 29 days following initial presentation demonstrated multifocal regions of hyperintensity on Diffusion Weighted Imaging (DWI) with a corresponding hypointensity on apparent diffusion coefficient (ADC) in the bilateral middle cerebral artery (MCA)-anterior cerebral artery (ACA) borderzones (Figure 2) . Critically-ill COVID-19 patients who remain comatose for prolonged periods following discontinuation of sedation may demonstrate features of hypoperfusion injury in borderzone regions despite the absence of sustained severe hypotension or hypoxia.	./cache/cord-309441-obojsf04.txt	./txt/cord-309441-obojsf04.txt