id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294443-w6p3f5qc	Nadar, Sunil K.	Managing hypertension during the COVID-19 pandemic	2020-05-14		.txt	text/plain	1642	82	48	Concern was therefore raised at the start of the pandemic that ACE inhibitors and angiotensin receptor blockers (ARBs), medications that are commonly used for hypertension and heart failure, could have a potential deleterious effect [11] , as ACE2 is widely expressed in the cardiovascular system and is up regulated by these drugs in some tissues in a subset of animal models [12, 13] . Subsequent data have raised the possibility that patients treated with ACE inhibitors or ARBs do indeed have a better outcome, with the crucial caveat that the possibility of unmeasured confounding and bias precludes drawing cause-effect conclusions from the clinical studies available thus far. A recent retrospective study from China comparing outcomes on hospitalised patients with COVID-19 with and without ACE inhibitors or ARBs for hypertension has suggested that in the former all-cause mortality was lower (adjusted HR, 0.42; 95% CI, 0.19-0.92; P = 0.03) [18] . Retrospective study of risk factors for severe SARS-Cov-2 infections in hospitalized adult patients.	./cache/cord-294443-w6p3f5qc.txt	./txt/cord-294443-w6p3f5qc.txt