id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293922-knzv4jvj	Zuo, Y.	Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients	2020-09-02		.txt	text/plain	3049	202	48	Results: We found markedly elevated levels of tPA and PAI-1 among patients hospitalized with COVID-19. Conclusion: While both tPA and PAI-1 are elevated among COVID-19 patients, extremely high levels of tPA enhance spontaneous fibrinolysis and are significantly associated with mortality in some patients. These data indicate that fibrinolytic homeostasis in COVID-19 is complex with a subset of patients expressing a balance of factors that may favor fibrinolysis and suggests that further study of tPA as a potential biomarker is warranted. Utilizing established Luminex platforms, we measured total PAI-1 and tPA levels in the plasma of 118 patients hospitalized with COVID-19 and 30 healthy controls. Elevated PAI-1 and its associated hypofibrinolytic state were observed in the 2002 SARS-CoV epidemic [22] , while recent characterizations of COVID-19 patients have suggested impaired global fibrinolysis [16, 23] . Interestingly, in our large cohort of hospitalized COVID-19 patients, we observed elevated levels of not only PAI-1, but also tPA.	./cache/cord-293922-knzv4jvj.txt	./txt/cord-293922-knzv4jvj.txt