id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291624-fod0eyuj	Malone, Robert W.	COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms	2020-06-22		.txt	text/plain	6496	354	43	We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H (2) activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release. Patients with COVID-19 disease can present with a range of mild to severe non-speci c clinical signs and symptoms which develop two to fourteen days after exposure to SARS-CoV-2. The most likely mechanisms of actions include: via antiviral activity, via novel human targets, or via the on-target mechanism described in the current FDA market authorization-famotidine is a histamine receptor H 2 antagonist (and inverse agonist). To assess the possibility that famotidine may inhibit SARS-CoV-2 infection by other routes, a Vero E6 cell-based assay was performed to compare median tissue culture infectious doses (TCID50/mL) of famotidine, remdesivir, and hydroxychloroquine ( Figure 2 ). In both of these studies, the observed non-in ammatory edema in early-stage COVID-19 pulmonary disease is consistent with histamine release by mast cells.	./cache/cord-291624-fod0eyuj.txt	./txt/cord-291624-fod0eyuj.txt