id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288222-8fqfbys2	Hardy, Michaël	Prothrombotic Disturbances of Hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Study	2020-10-24		.txt	text/plain	1198	69	47	The aim of this prospective study was therefore to describe the longitudinal changes in hemostasis parameters assessed daily in 21 COVID-19 patients during their intensive care unit (ICU) stay. Our main findings were that (i) daily standard measurements consistent with a prothrombotic state persisted over the first days and improved thereafter, but did not normalize in all patients; (ii) increased thrombin potential (hypercoagulability) and decreased fibrinolysis were frequent and (iii) a high inter-patient variability was observed. Patients initially were in a high inflammatory state (median CRP levels of 204 mg/dL during the first ten days after ICU admission); CRP levels progressively decreased over time thereafter. In light of these results and of the current knowledge on hemostasis disturbances of COVID-19 patients, we suggest that a close monitoring of a sensible set hemostatic parameters would be useful to assess individual thrombotic risk.	./cache/cord-288222-8fqfbys2.txt	./txt/cord-288222-8fqfbys2.txt