id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287786-zfe0el8i	Dudoignon, Emmanuel	Activation of the Renin-angiotensin-aldosterone system is associated with Acute Kidney injury in COVID-19	2020-06-18		.txt	text/plain	1011	69	49	title: Activation of the Renin-angiotensin-aldosterone system is associated with Acute Kidney injury in COVID-19 Abstract The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. Characterisation and understanding of COVID-19 renal injury would improve the management of patients admitted to the intensive care unit (ICU). Here, we describe the renal response of patients with COVID-19 patients admitted to an intensive care unit (ICU), with a particular focus on the activation of the renin-angiotensin-aldosterone system. Patients admitted to the ICU of St-Louis Hospital (Paris) between March 22 and April 15, 2020 for acute respiratory distress syndrome (Berlin Definition [7] ) with acute kidney injury (AKI, defined according to the Kidney Disease-Improving Global Outcome criteria [8] and using the admission serum creatinine as the baseline) were screened. Patients with AKI showed direct (increased plasma renin and aldosterone concentration) and indirect (low urine sodium concentration) markers of activation of the RAAS [3] .	./cache/cord-287786-zfe0el8i.txt	./txt/cord-287786-zfe0el8i.txt