id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287117-3v9nyagt	Monteagudo, Luke Adam	Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome	2020-04-21		.txt	text/plain	4638	266	47	OBJECTIVE: The objective of this study was to report the benefit of a therapeutic approach consisting of intravenous (IV) continuous anakinra (recombinant human interleukin‐1 receptor antagonist) infusions in treating severely ill adult patients with secondary hemophagocytic lymphohistiocytosis or macrophage activation syndrome (MAS). The diagnosis of MAS was made using the HLH-2004 criteria, which require five of the eight following findings: fever greater than or equal to 38.5°C, splenomegaly; peripheral blood cytopenias (at least two of the following: hemoglobin level less than 9 g/dl, platelet count less than 100 000 cells per μl, and absolute neutrophil count less than 1000 cells per μl); hypertriglyceridemia (fasting triglyceride level greater than 265 mg/dl) and/or hypofibrinogenemia (fibrinogen level less than 150 mg/dl); hemophagocytosis in the bone marrow, spleen, lymph node, or liver; low or absent natural killer cell activity; ferritin level greater than 500 ng/ml; and elevated soluble CD25 levels (sIL-2Rα) two SDs above age-adjusted laboratory-specific norms.	./cache/cord-287117-3v9nyagt.txt	./txt/cord-287117-3v9nyagt.txt