id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279357-83hisxro	de Leon, Jose	Clozapine is strongly associated with the risk of pneumonia and inflammation	2020-04-16		.txt	text/plain	4953	254	45	Clinicians need to remember that (1) systemic inflammations can increase clozapine level; (2) clozapine, by itself, can cause inflammation, particularly during titration that is too rapid for that patient; (3) clozapine may increase the risk of infection; and (4) more specifically, clozapine may be particularly strongly associated with the risk of pneumonia. 13 Therefore, based on the US 8 14 and Chinese experiences [11] [12] [13] as well as on the literature, 10 we proposed that clinicians need to be very alert regarding clozapine patients' risk of clozapine intoxications during any kind of systemic inflammation associated with fever and/or CRP elevations. Some case reports and observational studies previously reviewed in another article 11 suggest that infections can increase the serum concentrations of antipsychotics metabolised by CYP3A4.	./cache/cord-279357-83hisxro.txt	./txt/cord-279357-83hisxro.txt