id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277096-zvb7n9wo	Bond, David A.	Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma	2018-11-29		.txt	text/plain	3709	179	41	7 cHL is characterized by a relatively small proportion of pathologic Reed-Sternberg (RS) cells within a reactive inflammatory milieu and is associated with a state of increased Clinical Practice Points ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) is a widely used front-line regimen for the treatment of early and advanced stage classical Hodgkin lymphoma (cHL). We identified 3 patients experiencing febrile hypotensive reactions following ABVD chemotherapy at our institution with shared baseline clinical features, including stage IVB disease, high risk disease by International Prognostic Score, male gender, and Epstein-Barr virus-positive cHL. 15 Subsequent cases of fatal or life-threatening febrile, hypotensive reactions in patients with lymphoma treated with bleomycin as part of multi-agent therapy have been reported, [16] [17] [18] [19] including a patient with a febrile, hypotensive reaction following treatment with ABVD associated with tumor lysis syndrome (TLS) and markedly elevated serum IL-6.	./cache/cord-277096-zvb7n9wo.txt	./txt/cord-277096-zvb7n9wo.txt