id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274250-95yzt1gj	Mortaz, Esmaeil	Silent hypoxia: higher NO in red blood cells of COVID-19 patients	2020-10-16		.txt	text/plain	2716	159	48	The major clinical feature of severe COVID-19 requiring ventilation is acute respiratory distress syndrome (ARDS) with multi-functional failure as a result of a cytokine storm with increased serum levels of cytokines. The kinetics and allosteric regulation of Hb nitrosylation by oxygen and pH are consistent with the physiologic mechanisms that modulate tissue blood flow, namely acidosis and hypoxemia and tissue hypoxia leads to NO generation by the RBC via SNO-protein transfer of NO activity [12] . To examine the hypothesis that NO is important in regulating vasodilation during hypoxia in these subjects we studied intracellular levels of NO in COVID-19 patients. In our study, intracellular RBC NO of COVID-19 patients is significantly higher than in healthy controls and this may enable the release of oxygen to tissues resulting in the clinical manifestation of silent hypoxia in these patients.	./cache/cord-274250-95yzt1gj.txt	./txt/cord-274250-95yzt1gj.txt