id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273587-nja58vxw	Rendeiro, A. F.	Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression	2020-09-09		.txt	text/plain	8910	467	46	By profiling mild and severe COVID-19 patients and healthy donors with flow cytometry, we demonstrate that SARS-CoV-2 is associated with broad dysregulation of the circulating immune system, characterized by the relative loss of lymphoid cells coupled to expansion of myeloid cells. While we observed no significant differences in the relative abundance of KIR receptors among COVID-19 patients with mild disease and healthy controls (Figure 3f) , a significantly higher proportion of cells expressed CD158i (NKG2A) in severe patients compared with mild or convalescent individuals. Despite the backdrop of a relative decrease in B cell numbers as disease progresses, we observed only a mild, non-significant increase in plasmacytoid cells in patients with severe COVID-19 compared with healthy donors (Figure 4a) . The resulting network of significant effects identified several clinical factors associated with specific immune cell populations, highlighting how age, sex, and disease severity jointly influence the circulating immune systems in patients with COVID-19 (Figure 6a) .	./cache/cord-273587-nja58vxw.txt	./txt/cord-273587-nja58vxw.txt