id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260215-gsnjlhjd	Dhanani, Jayesh	Fundamentals of aerosol therapy in critical care	2016-10-07		.txt	text/plain	8319	485	36	Given that respiratory diseases are the commonest causes of critical illness, use of aerosol therapy to provide high local drug concentrations with minimal systemic side effects makes this route an attractive option. The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). NIV non-invasive ventilation, HME heat and moisture exchanger, pMDI pressurized metered dose inhaler, AAD adaptive aerosol device, VMN vibrating mesh nebulizer, DPI dry powder inhaler, PEEP positive end-expiratory pressure Fig. 3 Effects of regional lung aeration and pneumonia on drug concentration in lungs. The patient position, formulation, temperature, endotracheal tube size, presence of airway obstruction or ventilatory asynchrony, flow pattern, respiratory rate, dose and frequency applied or position of the nebulizer in the circuit are important factors that influence delivery to the lung.	./cache/cord-260215-gsnjlhjd.txt	./txt/cord-260215-gsnjlhjd.txt