id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257147-i48qljv6	Karakas, Mahir	Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)	2020-08-11		.txt	text/plain	3501	191	47	Clinical information for the 8 patients before and after the Adrecizumab administration was obtained from the hospital information system and included the following: demographic data, including anamnesis and physical examination; treatment and therapies, including mechanical ventilation and antiviral therapies; clinical data, including PaO2/FiO2, the SOFA score (range 0-24, with higher scores indicating a more severe illness), and the SAPS-II score (higher scores indicating a more severe illness); and laboratory data, including bio-ADM, DPP3, the white blood cell count, lactate, the liver and kidney function, and inflammatory factors (CRP, procalcitonin, and interleukin-6). In this preliminary uncontrolled case series of eight extreme-critically ill patients with COVID-19 and ARDS, the administration of the non-neutralizing anti-ADM antibody Adrecizumab was followed by a favorable outcome. In this preliminary uncontrolled case series of eight extreme-critically ill patients with COVID-19 and ARDS, the administration of the non-neutralizing anti-ADM antibody Adrecizumab was followed by a favorable outcome.	./cache/cord-257147-i48qljv6.txt	./txt/cord-257147-i48qljv6.txt