id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256639-4e0irb6d	Jean-Michel, Vanessa	Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation	2020-09-06		.txt	text/plain	842	61	49	title: Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation The Food and Drug Administration recently issued a midazolam shortage and reported a more than 50% consumption increase for other common sedative drugs such as propofol due to high demand for patients with COVID-19 [3] . For these patients, barbiturate therapy induce deep coma with bispectral index score lower than 20 and, as a result, prolonged MV [4] . Midazolam and propofol were completely stopped one hour after the thiopental loading dose in all patients. Another drug option for sedation of critically ill patients with COVID-19 could be inhaled volatile anaesthetics [9, 10] . Some studies have reported that inhaled agents such as isoflurane and sevoflurane shorten awakening and extubation times in mechanically ventilated patients compared to benzodiazepines or propofol. Thiopental seems to be an acceptable substitute to sedative drugs in this period of high midazolam and propofol demand for ICU patients with COVID-19.	./cache/cord-256639-4e0irb6d.txt	./txt/cord-256639-4e0irb6d.txt