id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-031256-4mxt501d	Van Der Poorten, Marie-Line M.	Non-irritating skin test concentrations for ceftazidime and aztreonam in patients with a documented beta-lactam allergy.	2020-09-01		.txt	text/plain	1724	121	60	Our study shows that the maximal non-irritant concentration (NIC) for ceftazidime and for aztreonam 32 is as high as 20 mg/mL for immediate readings of intradermal skin tests (IDT). (1) 42 This study aims at assessing the NIC for ceftazidime, a third generation cephalosporin, and 43 aztreonam, a synthetic monobactam, both potential safe alternative β-LABs in patients with a 44 documented hypersensitivity reaction to penicillin G, amoxicillin (+/-clavulanic acid) or cefazolin. Diagnosis of their Penicillin G, amoxicillin (+/-clavulanic acid) or cefazolin 52 hypersensitivity was based upon a history complemented by positive STs (immediate and delayed 53 readings), drug-reactive sIgE antibodies, a sIgE-to-tIgE ratio ≥ 0.002, or a graded drug challenge (DC). Our results show that the NICs for ceftazidime and aztreonam, as recommended in the ENDA/EAACI 102 Drug Allergy Interest Group position paper (3) and its update by Romano et al (8) , can further benefit 103 from an assessment in patients who experienced an IDHR or NIDHR to penicillin G, amoxicillin (+/-104 clavulanic acid) or an IDHR to cefazolin.	./cache/cord-031256-4mxt501d.txt	./txt/cord-031256-4mxt501d.txt