id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-031130-xvkyt3l3	Moreno-Duarte, Ingrid	Heparin Induced Thrombocytopenia for the Perioperative and Critical Care Clinician	2020-08-29		.txt	text/plain	6021	317	34	RECENT FINDINGS: Heparin-induced thrombocytopenia (HIT) occurs more frequently in surgical patients compared with medical patients due to the inflammatory release of platelet factor 4 and perioperative heparin exposure. Heparinoid exposure by syringe flush, subcutaneous prophylaxis, or therapeutic anticoagulation is common in the operative room (OR) and ICU environments [5] .Only a fraction of those with low platelet counts will develop HIT, which presents in approximately 0.3-0.5% of critically ill patients exposed to heparin [6] . Although HIT is less frequent in cardiac surgical patients compared with orthopedic patients, cardiac surgical patients have a higher frequency of HIT immunization (positive antibody formation) [15] , potentially due to the high intraoperative UFH doses required for anticoagulation on cardiopulmonary bypass [7, 17] . Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells	./cache/cord-031130-xvkyt3l3.txt	./txt/cord-031130-xvkyt3l3.txt