id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-013105-tmhce7p5	Kalil, Andre C.	Less is more: critically ill status is not a carte blanche for unlimited antibiotic use	2020-10-09		.txt	text/plain	1496	66	28	In addition, we propose that health-care providers can bring concrete and direct benefits to each of our critically ill patients at the bedside by preventing the excessive use of unnecessary antibiotics. The clinical deterioration of mechanically ventilated patients may be associated with a new infection process; however, the majority of ventilator-associated events leading to antibiotic administration is related to noninfectious processes [6] ; thus, the appropriate antimicrobial de-escalation is essential and can be safely done if culture results are negative [7, 8] . For many decades, critically ill patients have been treated with antibiotics during two to three weeks for severe infections including pneumonias, abdominal and urinary infections, all of which still comprise the majority of infections leading to sepsis and admission to the intensive care unit. Effect of aminoglycoside and beta-lactam combination therapy versus beta-lactam monotherapy on the emergence of antimicrobial resistance: a meta-analysis of randomized, controlled trials	./cache/cord-013105-tmhce7p5.txt	./txt/cord-013105-tmhce7p5.txt