id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007563-33jxxp1b	nan	Full Issue PDF	2018-06-25		.txt	text/plain	8282	475	46	In the present study, we investigated titin-isoform expression, total-titin and site-specific N2Bus/PEVK phosphorylation, and the degree of fibrosis in endomyocardial biopsy samples from AS patients compared with nonfailing donor heart samples. In our patient group, we found a significant shift toward the more compliant N2BA titin isoform versus nonfailing donor heart samples ( Figure 2) . This GCH1-GFRP complex is operative in humans because oral challenge with L-phe leads to a 3-fold rise in plasma biopterin levels (a correlate of BH 4 )-an effect that is attenuated in patients with a loss-of-function GCH1 mutation (23 To support this hypothesis, it is known the GCH1-GFRP axis regulates BH 4 and NO in endothelial cells (25) . Some studies report that elevations in circulating biomarkers of oxidative stress (myeloperoxidase) precede clinically significant systolic dysfunction in anthracycline-treated patients (8, 15 CT images were used to localize the heart and confirm the epicardial surfaces for VOI edge placement.	./cache/cord-007563-33jxxp1b.txt	./txt/cord-007563-33jxxp1b.txt