id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004949-icsey27p	Fernandez-Botran, Rafael	Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia	2014-02-21		.txt	text/plain	4044	193	43	The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Compared to non-severe CAP patients, the severe CAP group showed higher plasma levels of proand anti-inflammatory cytokines but in contrast, lower sputum concentrations of pro-inflammatory cytokines. The objectives of this study were to characterize and contrast the lung and systemic cytokine profiles as well as blood neutrophil responses in patients with severe versus non-severe CAP at the time of hospital admission. In order to compare results of the plasma cytokines and neutrophil functional assays from CAP patients with those of healthy individuals, blood samples were also obtained from a control group (n=12) of healthy adult donors (approved by the University of Louisville′s IRB #191.06). Generally, patients in the severe CAP group showed a pattern with median plasma concentrations of both pro-and anti-inflammatory cytokines that were higher in comparison with the non-severe CAP group and the healthy control group.	./cache/cord-004949-icsey27p.txt	./txt/cord-004949-icsey27p.txt