id sid tid token lemma pos cord-347946-i6kx3n6m 1 1 key key NN cord-347946-i6kx3n6m 1 2 : : : cord-347946-i6kx3n6m 2 1 cord-347946-i6kx3n6 cord-347946-i6kx3n6 NNP cord-347946-i6kx3n6m 2 2 m m CD cord-347946-i6kx3n6m 2 3 authors author NNS cord-347946-i6kx3n6m 2 4 : : : cord-347946-i6kx3n6m 2 5 Raison Raison NNP cord-347946-i6kx3n6m 2 6 , , , cord-347946-i6kx3n6m 2 7 Charles Charles NNP cord-347946-i6kx3n6m 2 8 L L NNP cord-347946-i6kx3n6m 2 9 ; ; : cord-347946-i6kx3n6m 2 10 Miller Miller NNP cord-347946-i6kx3n6m 2 11 , , , cord-347946-i6kx3n6m 2 12 Andrew Andrew NNP cord-347946-i6kx3n6m 2 13 H H NNP cord-347946-i6kx3n6m 2 14 title title NN cord-347946-i6kx3n6m 2 15 : : : cord-347946-i6kx3n6m 2 16 Pathogen Pathogen NNP cord-347946-i6kx3n6m 2 17 – – : cord-347946-i6kx3n6m 2 18 Host Host NNP cord-347946-i6kx3n6m 2 19 Defense Defense NNP cord-347946-i6kx3n6m 2 20 in in IN cord-347946-i6kx3n6m 2 21 the the DT cord-347946-i6kx3n6m 2 22 Evolution Evolution NNP cord-347946-i6kx3n6m 2 23 of of IN cord-347946-i6kx3n6m 2 24 Depression Depression NNP cord-347946-i6kx3n6m 2 25 : : : cord-347946-i6kx3n6m 3 1 Insights insight NNS cord-347946-i6kx3n6m 3 2 into into IN cord-347946-i6kx3n6m 3 3 Epidemiology Epidemiology NNP cord-347946-i6kx3n6m 3 4 , , , cord-347946-i6kx3n6m 3 5 Genetics Genetics NNP cord-347946-i6kx3n6m 3 6 , , , cord-347946-i6kx3n6m 3 7 Bioregional Bioregional NNP cord-347946-i6kx3n6m 3 8 Differences Differences NNPS cord-347946-i6kx3n6m 3 9 and and CC cord-347946-i6kx3n6m 3 10 Female female JJ cord-347946-i6kx3n6m 3 11 Preponderance Preponderance NNP cord-347946-i6kx3n6m 3 12 date date NN cord-347946-i6kx3n6m 3 13 : : : cord-347946-i6kx3n6m 3 14 2016 2016 CD cord-347946-i6kx3n6m 3 15 - - HYPH cord-347946-i6kx3n6m 3 16 09 09 CD cord-347946-i6kx3n6m 3 17 - - SYM cord-347946-i6kx3n6m 3 18 15 15 CD cord-347946-i6kx3n6m 3 19 journal journal NN cord-347946-i6kx3n6m 3 20 : : : cord-347946-i6kx3n6m 4 1 Neuropsychopharmacology Neuropsychopharmacology NNP cord-347946-i6kx3n6m 4 2 DOI doi NN cord-347946-i6kx3n6m 4 3 : : : cord-347946-i6kx3n6m 5 1 10.1038 10.1038 CD cord-347946-i6kx3n6m 5 2 / / SYM cord-347946-i6kx3n6m 5 3 npp.2016.194 npp.2016.194 NNP cord-347946-i6kx3n6m 5 4 sha sha NNP cord-347946-i6kx3n6m 5 5 : : : cord-347946-i6kx3n6m 5 6 841791e86c12318b7552ccbc20932cfbde1e094d 841791e86c12318b7552ccbc20932cfbde1e094d CD cord-347946-i6kx3n6m 5 7 doc_id doc_id CD cord-347946-i6kx3n6m 5 8 : : : cord-347946-i6kx3n6m 5 9 347946 347946 CD cord-347946-i6kx3n6m 5 10 cord_uid cord_uid NNS cord-347946-i6kx3n6m 5 11 : : : cord-347946-i6kx3n6m 5 12 i6kx3n6 i6kx3n6 NN cord-347946-i6kx3n6m 6 1 m m LS cord-347946-i6kx3n6m 6 2 Significant significant JJ cord-347946-i6kx3n6m 6 3 attention attention NN cord-347946-i6kx3n6m 6 4 has have VBZ cord-347946-i6kx3n6m 6 5 been be VBN cord-347946-i6kx3n6m 6 6 paid pay VBN cord-347946-i6kx3n6m 6 7 to to IN cord-347946-i6kx3n6m 6 8 the the DT cord-347946-i6kx3n6m 6 9 potential potential JJ cord-347946-i6kx3n6m 6 10 adaptive adaptive JJ cord-347946-i6kx3n6m 6 11 value value NN cord-347946-i6kx3n6m 6 12 of of IN cord-347946-i6kx3n6m 6 13 depression depression NN cord-347946-i6kx3n6m 6 14 as as IN cord-347946-i6kx3n6m 6 15 it -PRON- PRP cord-347946-i6kx3n6m 6 16 relates relate VBZ cord-347946-i6kx3n6m 6 17 to to IN cord-347946-i6kx3n6m 6 18 interactions interaction NNS cord-347946-i6kx3n6m 6 19 with with IN cord-347946-i6kx3n6m 6 20 people people NNS cord-347946-i6kx3n6m 6 21 in in IN cord-347946-i6kx3n6m 6 22 the the DT cord-347946-i6kx3n6m 6 23 social social JJ cord-347946-i6kx3n6m 6 24 world world NN cord-347946-i6kx3n6m 6 25 . . . cord-347946-i6kx3n6m 7 1 However however RB cord-347946-i6kx3n6m 7 2 , , , cord-347946-i6kx3n6m 7 3 in in IN cord-347946-i6kx3n6m 7 4 this this DT cord-347946-i6kx3n6m 7 5 review review NN cord-347946-i6kx3n6m 7 6 , , , cord-347946-i6kx3n6m 7 7 we -PRON- PRP cord-347946-i6kx3n6m 7 8 outline outline VBP cord-347946-i6kx3n6m 7 9 the the DT cord-347946-i6kx3n6m 7 10 rationale rationale NN cord-347946-i6kx3n6m 7 11 of of IN cord-347946-i6kx3n6m 7 12 why why WRB cord-347946-i6kx3n6m 7 13 certain certain JJ cord-347946-i6kx3n6m 7 14 features feature NNS cord-347946-i6kx3n6m 7 15 of of IN cord-347946-i6kx3n6m 7 16 depression depression NN cord-347946-i6kx3n6m 7 17 including include VBG cord-347946-i6kx3n6m 7 18 its -PRON- PRP$ cord-347946-i6kx3n6m 7 19 environmental environmental JJ cord-347946-i6kx3n6m 7 20 and and CC cord-347946-i6kx3n6m 7 21 genetic genetic JJ cord-347946-i6kx3n6m 7 22 risk risk NN cord-347946-i6kx3n6m 7 23 factors factor NNS cord-347946-i6kx3n6m 7 24 , , , cord-347946-i6kx3n6m 7 25 its -PRON- PRP$ cord-347946-i6kx3n6m 7 26 association association NN cord-347946-i6kx3n6m 7 27 with with IN cord-347946-i6kx3n6m 7 28 the the DT cord-347946-i6kx3n6m 7 29 acute acute JJ cord-347946-i6kx3n6m 7 30 phase phase NN cord-347946-i6kx3n6m 7 31 response response NN cord-347946-i6kx3n6m 7 32 and and CC cord-347946-i6kx3n6m 7 33 its -PRON- PRP$ cord-347946-i6kx3n6m 7 34 age age NN cord-347946-i6kx3n6m 7 35 of of IN cord-347946-i6kx3n6m 7 36 onset onset NN cord-347946-i6kx3n6m 7 37 and and CC cord-347946-i6kx3n6m 7 38 female female JJ cord-347946-i6kx3n6m 7 39 preponderance preponderance NN cord-347946-i6kx3n6m 7 40 appear appear VBP cord-347946-i6kx3n6m 7 41 to to TO cord-347946-i6kx3n6m 7 42 have have VB cord-347946-i6kx3n6m 7 43 evolved evolve VBN cord-347946-i6kx3n6m 7 44 from from IN cord-347946-i6kx3n6m 7 45 human human JJ cord-347946-i6kx3n6m 7 46 interactions interaction NNS cord-347946-i6kx3n6m 7 47 with with IN cord-347946-i6kx3n6m 7 48 pathogens pathogen NNS cord-347946-i6kx3n6m 7 49 in in IN cord-347946-i6kx3n6m 7 50 the the DT cord-347946-i6kx3n6m 7 51 microbial microbial JJ cord-347946-i6kx3n6m 7 52 world world NN cord-347946-i6kx3n6m 7 53 . . . cord-347946-i6kx3n6m 8 1 Approaching approach VBG cord-347946-i6kx3n6m 8 2 the the DT cord-347946-i6kx3n6m 8 3 relationship relationship NN cord-347946-i6kx3n6m 8 4 between between IN cord-347946-i6kx3n6m 8 5 inflammation inflammation NN cord-347946-i6kx3n6m 8 6 and and CC cord-347946-i6kx3n6m 8 7 depression depression NN cord-347946-i6kx3n6m 8 8 from from IN cord-347946-i6kx3n6m 8 9 this this DT cord-347946-i6kx3n6m 8 10 evolutionary evolutionary JJ cord-347946-i6kx3n6m 8 11 perspective perspective NN cord-347946-i6kx3n6m 8 12 yields yield VBZ cord-347946-i6kx3n6m 8 13 a a DT cord-347946-i6kx3n6m 8 14 number number NN cord-347946-i6kx3n6m 8 15 of of IN cord-347946-i6kx3n6m 8 16 insights insight NNS cord-347946-i6kx3n6m 8 17 that that WDT cord-347946-i6kx3n6m 8 18 may may MD cord-347946-i6kx3n6m 8 19 reveal reveal VB cord-347946-i6kx3n6m 8 20 important important JJ cord-347946-i6kx3n6m 8 21 clues clue NNS cord-347946-i6kx3n6m 8 22 regarding regard VBG cord-347946-i6kx3n6m 8 23 the the DT cord-347946-i6kx3n6m 8 24 origin origin NN cord-347946-i6kx3n6m 8 25 and and CC cord-347946-i6kx3n6m 8 26 epidemiology epidemiology NN cord-347946-i6kx3n6m 8 27 of of IN cord-347946-i6kx3n6m 8 28 the the DT cord-347946-i6kx3n6m 8 29 disorder disorder NN cord-347946-i6kx3n6m 8 30 as as RB cord-347946-i6kx3n6m 8 31 well well RB cord-347946-i6kx3n6m 8 32 as as IN cord-347946-i6kx3n6m 8 33 the the DT cord-347946-i6kx3n6m 8 34 persistence persistence NN cord-347946-i6kx3n6m 8 35 of of IN cord-347946-i6kx3n6m 8 36 its -PRON- PRP$ cord-347946-i6kx3n6m 8 37 risk risk NN cord-347946-i6kx3n6m 8 38 alleles allele NNS cord-347946-i6kx3n6m 8 39 in in IN cord-347946-i6kx3n6m 8 40 the the DT cord-347946-i6kx3n6m 8 41 modern modern JJ cord-347946-i6kx3n6m 8 42 human human JJ cord-347946-i6kx3n6m 8 43 genome genome NN cord-347946-i6kx3n6m 8 44 . . . cord-347946-i6kx3n6m 9 1 Major major JJ cord-347946-i6kx3n6m 9 2 depressive depressive JJ cord-347946-i6kx3n6m 9 3 disorder disorder NN cord-347946-i6kx3n6m 9 4 ( ( -LRB- cord-347946-i6kx3n6m 9 5 MDD MDD NNP cord-347946-i6kx3n6m 9 6 ) ) -RRB- cord-347946-i6kx3n6m 9 7 is be VBZ cord-347946-i6kx3n6m 9 8 about about IN cord-347946-i6kx3n6m 9 9 relationships relationship NNS cord-347946-i6kx3n6m 9 10 . . . cord-347946-i6kx3n6m 10 1 Or or CC cord-347946-i6kx3n6m 10 2 so so RB cord-347946-i6kx3n6m 10 3 one one PRP cord-347946-i6kx3n6m 10 4 would would MD cord-347946-i6kx3n6m 10 5 think think VB cord-347946-i6kx3n6m 10 6 based base VBN cord-347946-i6kx3n6m 10 7 on on IN cord-347946-i6kx3n6m 10 8 an an DT cord-347946-i6kx3n6m 10 9 extensive extensive JJ cord-347946-i6kx3n6m 10 10 literature literature NN cord-347946-i6kx3n6m 10 11 that that WDT cord-347946-i6kx3n6m 10 12 seeks seek VBZ cord-347946-i6kx3n6m 10 13 to to TO cord-347946-i6kx3n6m 10 14 explain explain VB cord-347946-i6kx3n6m 10 15 how how WRB cord-347946-i6kx3n6m 10 16 a a DT cord-347946-i6kx3n6m 10 17 condition condition NN cord-347946-i6kx3n6m 10 18 with with IN cord-347946-i6kx3n6m 10 19 genetic genetic JJ cord-347946-i6kx3n6m 10 20 underpinnings underpinning NNS cord-347946-i6kx3n6m 10 21 could could MD cord-347946-i6kx3n6m 10 22 be be VB cord-347946-i6kx3n6m 10 23 so so RB cord-347946-i6kx3n6m 10 24 widespread widespread JJ cord-347946-i6kx3n6m 10 25 when when WRB cord-347946-i6kx3n6m 10 26 it -PRON- PRP cord-347946-i6kx3n6m 10 27 is be VBZ cord-347946-i6kx3n6m 10 28 so so RB cord-347946-i6kx3n6m 10 29 apparently apparently RB cord-347946-i6kx3n6m 10 30 inimical inimical JJ cord-347946-i6kx3n6m 10 31 to to IN cord-347946-i6kx3n6m 10 32 the the DT cord-347946-i6kx3n6m 10 33 Darwinian darwinian JJ cord-347946-i6kx3n6m 10 34 mandates mandate NNS cord-347946-i6kx3n6m 10 35 of of IN cord-347946-i6kx3n6m 10 36 survival survival NN cord-347946-i6kx3n6m 10 37 and and CC cord-347946-i6kx3n6m 10 38 reproduction reproduction NN cord-347946-i6kx3n6m 10 39 . . . cord-347946-i6kx3n6m 11 1 This this DT cord-347946-i6kx3n6m 11 2 literature literature NN cord-347946-i6kx3n6m 11 3 on on IN cord-347946-i6kx3n6m 11 4 adaptive adaptive JJ cord-347946-i6kx3n6m 11 5 theory theory NN cord-347946-i6kx3n6m 11 6 bifurcates bifurcate VBZ cord-347946-i6kx3n6m 11 7 over over IN cord-347946-i6kx3n6m 11 8 whether whether IN cord-347946-i6kx3n6m 11 9 depression depression NN cord-347946-i6kx3n6m 11 10 is be VBZ cord-347946-i6kx3n6m 11 11 adaptive adaptive JJ cord-347946-i6kx3n6m 11 12 in in IN cord-347946-i6kx3n6m 11 13 and and CC cord-347946-i6kx3n6m 11 14 of of IN cord-347946-i6kx3n6m 11 15 itself -PRON- PRP cord-347946-i6kx3n6m 11 16 or or CC cord-347946-i6kx3n6m 11 17 whether whether IN cord-347946-i6kx3n6m 11 18 the the DT cord-347946-i6kx3n6m 11 19 genes gene NNS cord-347946-i6kx3n6m 11 20 that that WDT cord-347946-i6kx3n6m 11 21 increase increase VBP cord-347946-i6kx3n6m 11 22 the the DT cord-347946-i6kx3n6m 11 23 risk risk NN cord-347946-i6kx3n6m 11 24 of of IN cord-347946-i6kx3n6m 11 25 depression depression NN cord-347946-i6kx3n6m 11 26 also also RB cord-347946-i6kx3n6m 11 27 promote promote VBP cord-347946-i6kx3n6m 11 28 other other JJ cord-347946-i6kx3n6m 11 29 types type NNS cord-347946-i6kx3n6m 11 30 of of IN cord-347946-i6kx3n6m 11 31 social social JJ cord-347946-i6kx3n6m 11 32 behavior behavior NN cord-347946-i6kx3n6m 11 33 ( ( -LRB- cord-347946-i6kx3n6m 11 34 ie ie FW cord-347946-i6kx3n6m 11 35 , , , cord-347946-i6kx3n6m 11 36 avoiding avoid VBG cord-347946-i6kx3n6m 11 37 conflict conflict NN cord-347946-i6kx3n6m 11 38 with with IN cord-347946-i6kx3n6m 11 39 more more RBR cord-347946-i6kx3n6m 11 40 powerful powerful JJ cord-347946-i6kx3n6m 11 41 individuals individual NNS cord-347946-i6kx3n6m 11 42 ) ) -RRB- cord-347946-i6kx3n6m 11 43 that that WDT cord-347946-i6kx3n6m 11 44 promoted promote VBD cord-347946-i6kx3n6m 11 45 survival survival NN cord-347946-i6kx3n6m 11 46 and and CC cord-347946-i6kx3n6m 11 47 reproduction reproduction NN cord-347946-i6kx3n6m 11 48 sufficiently sufficiently RB cord-347946-i6kx3n6m 11 49 to to TO cord-347946-i6kx3n6m 11 50 have have VB cord-347946-i6kx3n6m 11 51 been be VBN cord-347946-i6kx3n6m 11 52 retained retain VBN cord-347946-i6kx3n6m 11 53 in in IN cord-347946-i6kx3n6m 11 54 the the DT cord-347946-i6kx3n6m 11 55 human human JJ cord-347946-i6kx3n6m 11 56 genome genome NN cord-347946-i6kx3n6m 11 57 ( ( -LRB- cord-347946-i6kx3n6m 11 58 Supplementary Supplementary NNP cord-347946-i6kx3n6m 11 59 Table Table NNP cord-347946-i6kx3n6m 11 60 S1 S1 NNP cord-347946-i6kx3n6m 11 61 ) ) -RRB- cord-347946-i6kx3n6m 11 62 . . . cord-347946-i6kx3n6m 12 1 Despite despite IN cord-347946-i6kx3n6m 12 2 differences difference NNS cord-347946-i6kx3n6m 12 3 , , , cord-347946-i6kx3n6m 12 4 however however RB cord-347946-i6kx3n6m 12 5 , , , cord-347946-i6kx3n6m 12 6 these these DT cord-347946-i6kx3n6m 12 7 theories theory NNS cord-347946-i6kx3n6m 12 8 all all DT cord-347946-i6kx3n6m 12 9 share share VBP cord-347946-i6kx3n6m 12 10 in in IN cord-347946-i6kx3n6m 12 11 common common JJ cord-347946-i6kx3n6m 12 12 the the DT cord-347946-i6kx3n6m 12 13 notion notion NN cord-347946-i6kx3n6m 12 14 that that IN cord-347946-i6kx3n6m 12 15 the the DT cord-347946-i6kx3n6m 12 16 adaptive adaptive JJ cord-347946-i6kx3n6m 12 17 value value NN cord-347946-i6kx3n6m 12 18 of of IN cord-347946-i6kx3n6m 12 19 MDD MDD NNP cord-347946-i6kx3n6m 12 20 is be VBZ cord-347946-i6kx3n6m 12 21 to to TO cord-347946-i6kx3n6m 12 22 be be VB cord-347946-i6kx3n6m 12 23 found find VBN cord-347946-i6kx3n6m 12 24 in in IN cord-347946-i6kx3n6m 12 25 its -PRON- PRP$ cord-347946-i6kx3n6m 12 26 effects effect NNS cord-347946-i6kx3n6m 12 27 on on IN cord-347946-i6kx3n6m 12 28 our -PRON- PRP$ cord-347946-i6kx3n6m 12 29 relationships relationship NNS cord-347946-i6kx3n6m 12 30 with with IN cord-347946-i6kx3n6m 12 31 other other JJ cord-347946-i6kx3n6m 12 32 people people NNS cord-347946-i6kx3n6m 12 33 . . . cord-347946-i6kx3n6m 13 1 We -PRON- PRP cord-347946-i6kx3n6m 13 2 agree agree VBP cord-347946-i6kx3n6m 13 3 that that IN cord-347946-i6kx3n6m 13 4 the the DT cord-347946-i6kx3n6m 13 5 adaptive adaptive JJ cord-347946-i6kx3n6m 13 6 value value NN cord-347946-i6kx3n6m 13 7 of of IN cord-347946-i6kx3n6m 13 8 MDD MDD NNP cord-347946-i6kx3n6m 13 9 is be VBZ cord-347946-i6kx3n6m 13 10 to to TO cord-347946-i6kx3n6m 13 11 be be VB cord-347946-i6kx3n6m 13 12 found find VBN cord-347946-i6kx3n6m 13 13 in in IN cord-347946-i6kx3n6m 13 14 our -PRON- PRP$ cord-347946-i6kx3n6m 13 15 relationships relationship NNS cord-347946-i6kx3n6m 13 16 , , , cord-347946-i6kx3n6m 13 17 but but CC cord-347946-i6kx3n6m 13 18 not not RB cord-347946-i6kx3n6m 13 19 primarily primarily RB cord-347946-i6kx3n6m 13 20 in in IN cord-347946-i6kx3n6m 13 21 our -PRON- PRP$ cord-347946-i6kx3n6m 13 22 relationships relationship NNS cord-347946-i6kx3n6m 13 23 with with IN cord-347946-i6kx3n6m 13 24 other other JJ cord-347946-i6kx3n6m 13 25 humans human NNS cord-347946-i6kx3n6m 13 26 . . . cord-347946-i6kx3n6m 14 1 Rather rather RB cord-347946-i6kx3n6m 14 2 , , , cord-347946-i6kx3n6m 14 3 in in IN cord-347946-i6kx3n6m 14 4 this this DT cord-347946-i6kx3n6m 14 5 review review NN cord-347946-i6kx3n6m 14 6 we -PRON- PRP cord-347946-i6kx3n6m 14 7 argue argue VBP cord-347946-i6kx3n6m 14 8 that that IN cord-347946-i6kx3n6m 14 9 MDD MDD NNP cord-347946-i6kx3n6m 14 10 , , , cord-347946-i6kx3n6m 14 11 and and CC cord-347946-i6kx3n6m 14 12 the the DT cord-347946-i6kx3n6m 14 13 genes gene NNS cord-347946-i6kx3n6m 14 14 that that WDT cord-347946-i6kx3n6m 14 15 subserve subserve VBP cord-347946-i6kx3n6m 14 16 it -PRON- PRP cord-347946-i6kx3n6m 14 17 , , , cord-347946-i6kx3n6m 14 18 evolved evolve VBD cord-347946-i6kx3n6m 14 19 to to TO cord-347946-i6kx3n6m 14 20 help help VB cord-347946-i6kx3n6m 14 21 us -PRON- PRP cord-347946-i6kx3n6m 14 22 manage manage VB cord-347946-i6kx3n6m 14 23 relationships relationship NNS cord-347946-i6kx3n6m 14 24 with with IN cord-347946-i6kx3n6m 14 25 the the DT cord-347946-i6kx3n6m 14 26 wide wide JJ cord-347946-i6kx3n6m 14 27 range range NN cord-347946-i6kx3n6m 14 28 of of IN cord-347946-i6kx3n6m 14 29 pathogens pathogen NNS cord-347946-i6kx3n6m 14 30 with with IN cord-347946-i6kx3n6m 14 31 which which WDT cord-347946-i6kx3n6m 14 32 humans human NNS cord-347946-i6kx3n6m 14 33 co co VBD cord-347946-i6kx3n6m 14 34 - - VBD cord-347946-i6kx3n6m 14 35 evolved evolved JJ cord-347946-i6kx3n6m 14 36 . . . cord-347946-i6kx3n6m 15 1 Specifically specifically RB cord-347946-i6kx3n6m 15 2 , , , cord-347946-i6kx3n6m 15 3 at at IN cord-347946-i6kx3n6m 15 4 least least JJS cord-347946-i6kx3n6m 15 5 some some DT cord-347946-i6kx3n6m 15 6 of of IN cord-347946-i6kx3n6m 15 7 the the DT cord-347946-i6kx3n6m 15 8 genes gene NNS cord-347946-i6kx3n6m 15 9 that that WDT cord-347946-i6kx3n6m 15 10 promote promote VBP cord-347946-i6kx3n6m 15 11 MDD MDD NNP cord-347946-i6kx3n6m 15 12 evolved evolve VBD cord-347946-i6kx3n6m 15 13 and and CC cord-347946-i6kx3n6m 15 14 have have VBP cord-347946-i6kx3n6m 15 15 been be VBN cord-347946-i6kx3n6m 15 16 retained retain VBN cord-347946-i6kx3n6m 15 17 in in IN cord-347946-i6kx3n6m 15 18 the the DT cord-347946-i6kx3n6m 15 19 human human JJ cord-347946-i6kx3n6m 15 20 genome genome NN cord-347946-i6kx3n6m 15 21 because because IN cord-347946-i6kx3n6m 15 22 - - HYPH cord-347946-i6kx3n6m 15 23 on on RP cord-347946-i6kx3n6m 15 24 average average NN cord-347946-i6kx3n6m 15 25 - - : cord-347946-i6kx3n6m 15 26 they -PRON- PRP cord-347946-i6kx3n6m 15 27 helped help VBD cord-347946-i6kx3n6m 15 28 hominids hominid NNS cord-347946-i6kx3n6m 15 29 avoid avoid VB cord-347946-i6kx3n6m 15 30 death death NN cord-347946-i6kx3n6m 15 31 from from IN cord-347946-i6kx3n6m 15 32 infection infection NN cord-347946-i6kx3n6m 15 33 . . . cord-347946-i6kx3n6m 16 1 Importantly importantly RB cord-347946-i6kx3n6m 16 2 , , , cord-347946-i6kx3n6m 16 3 we -PRON- PRP cord-347946-i6kx3n6m 16 4 are be VBP cord-347946-i6kx3n6m 16 5 not not RB cord-347946-i6kx3n6m 16 6 suggesting suggest VBG cord-347946-i6kx3n6m 16 7 that that IN cord-347946-i6kx3n6m 16 8 these these DT cord-347946-i6kx3n6m 16 9 genes gene NNS cord-347946-i6kx3n6m 16 10 promoted promote VBD cord-347946-i6kx3n6m 16 11 host host NN cord-347946-i6kx3n6m 16 12 defense defense NN cord-347946-i6kx3n6m 16 13 against against IN cord-347946-i6kx3n6m 16 14 pathogens pathogen NNS cord-347946-i6kx3n6m 16 15 at at IN cord-347946-i6kx3n6m 16 16 the the DT cord-347946-i6kx3n6m 16 17 cost cost NN cord-347946-i6kx3n6m 16 18 of of IN cord-347946-i6kx3n6m 16 19 inducing induce VBG cord-347946-i6kx3n6m 16 20 depression depression NN cord-347946-i6kx3n6m 16 21 . . . cord-347946-i6kx3n6m 17 1 Rather rather RB cord-347946-i6kx3n6m 17 2 , , , cord-347946-i6kx3n6m 17 3 the the DT cord-347946-i6kx3n6m 17 4 tendency tendency NN cord-347946-i6kx3n6m 17 5 of of IN cord-347946-i6kx3n6m 17 6 these these DT cord-347946-i6kx3n6m 17 7 genes gene NNS cord-347946-i6kx3n6m 17 8 to to TO cord-347946-i6kx3n6m 17 9 induce induce VB cord-347946-i6kx3n6m 17 10 depression depression NN cord-347946-i6kx3n6m 17 11 and and CC cord-347946-i6kx3n6m 17 12 other other JJ cord-347946-i6kx3n6m 17 13 related relate VBN cord-347946-i6kx3n6m 17 14 behavioral behavioral JJ cord-347946-i6kx3n6m 17 15 changes change NNS cord-347946-i6kx3n6m 17 16 including include VBG cord-347946-i6kx3n6m 17 17 arousal arousal NN cord-347946-i6kx3n6m 17 18 , , , cord-347946-i6kx3n6m 17 19 anxiety anxiety NN cord-347946-i6kx3n6m 17 20 and and CC cord-347946-i6kx3n6m 17 21 alarm alarm NN cord-347946-i6kx3n6m 17 22 is be VBZ cord-347946-i6kx3n6m 17 23 integral integral JJ cord-347946-i6kx3n6m 17 24 to to IN cord-347946-i6kx3n6m 17 25 their -PRON- PRP$ cord-347946-i6kx3n6m 17 26 anti anti JJ cord-347946-i6kx3n6m 17 27 - - JJ cord-347946-i6kx3n6m 17 28 pathogen pathogen JJ cord-347946-i6kx3n6m 17 29 benefits benefit NNS cord-347946-i6kx3n6m 17 30 , , , cord-347946-i6kx3n6m 17 31 becauselike becauselike NN cord-347946-i6kx3n6m 17 32 sickness sickness NN cord-347946-i6kx3n6m 17 33 from from IN cord-347946-i6kx3n6m 17 34 which which WDT cord-347946-i6kx3n6m 17 35 it -PRON- PRP cord-347946-i6kx3n6m 17 36 evolved evolve VBD cord-347946-i6kx3n6m 17 37 - - : cord-347946-i6kx3n6m 17 38 depression depression NN cord-347946-i6kx3n6m 17 39 conferred confer VBD cord-347946-i6kx3n6m 17 40 protection protection NN cord-347946-i6kx3n6m 17 41 from from IN cord-347946-i6kx3n6m 17 42 pathogens pathogen NNS cord-347946-i6kx3n6m 17 43 in in IN cord-347946-i6kx3n6m 17 44 the the DT cord-347946-i6kx3n6m 17 45 environments environment NNS cord-347946-i6kx3n6m 17 46 in in IN cord-347946-i6kx3n6m 17 47 which which WDT cord-347946-i6kx3n6m 17 48 humans human NNS cord-347946-i6kx3n6m 17 49 evolved evolve VBD cord-347946-i6kx3n6m 17 50 . . . cord-347946-i6kx3n6m 18 1 Said say VBD cord-347946-i6kx3n6m 18 2 differently differently RB cord-347946-i6kx3n6m 18 3 , , , cord-347946-i6kx3n6m 18 4 depression depression NN cord-347946-i6kx3n6m 18 5 may may MD cord-347946-i6kx3n6m 18 6 itself -PRON- PRP cord-347946-i6kx3n6m 18 7 be be VB cord-347946-i6kx3n6m 18 8 an an DT cord-347946-i6kx3n6m 18 9 anti anti JJ cord-347946-i6kx3n6m 18 10 - - JJ cord-347946-i6kx3n6m 18 11 pathogen pathogen JJ cord-347946-i6kx3n6m 18 12 defense defense NN cord-347946-i6kx3n6m 18 13 strategy strategy NN cord-347946-i6kx3n6m 18 14 , , , cord-347946-i6kx3n6m 18 15 one one CD cord-347946-i6kx3n6m 18 16 that that WDT cord-347946-i6kx3n6m 18 17 is be VBZ cord-347946-i6kx3n6m 18 18 both both DT cord-347946-i6kx3n6m 18 19 activated activate VBN cord-347946-i6kx3n6m 18 20 by by IN cord-347946-i6kx3n6m 18 21 inflammation inflammation NN cord-347946-i6kx3n6m 18 22 and and CC cord-347946-i6kx3n6m 18 23 , , , cord-347946-i6kx3n6m 18 24 somewhat somewhat RB cord-347946-i6kx3n6m 18 25 paradoxically paradoxically RB cord-347946-i6kx3n6m 18 26 , , , cord-347946-i6kx3n6m 18 27 one one CD cord-347946-i6kx3n6m 18 28 that that WDT cord-347946-i6kx3n6m 18 29 across across IN cord-347946-i6kx3n6m 18 30 evolutionary evolutionary JJ cord-347946-i6kx3n6m 18 31 time time NN cord-347946-i6kx3n6m 18 32 may may MD cord-347946-i6kx3n6m 18 33 have have VB cord-347946-i6kx3n6m 18 34 made make VBN cord-347946-i6kx3n6m 18 35 inflammatory inflammatory JJ cord-347946-i6kx3n6m 18 36 activation activation NN cord-347946-i6kx3n6m 18 37 less less RBR cord-347946-i6kx3n6m 18 38 necessary necessary JJ cord-347946-i6kx3n6m 18 39 , , , cord-347946-i6kx3n6m 18 40 as as IN cord-347946-i6kx3n6m 18 41 we -PRON- PRP cord-347946-i6kx3n6m 18 42 shall shall MD cord-347946-i6kx3n6m 18 43 see see VB cord-347946-i6kx3n6m 18 44 in in IN cord-347946-i6kx3n6m 18 45 our -PRON- PRP$ cord-347946-i6kx3n6m 18 46 discussion discussion NN cord-347946-i6kx3n6m 18 47 of of IN cord-347946-i6kx3n6m 18 48 sex sex NN cord-347946-i6kx3n6m 18 49 differences difference NNS cord-347946-i6kx3n6m 18 50 in in IN cord-347946-i6kx3n6m 18 51 the the DT cord-347946-i6kx3n6m 18 52 prevalence prevalence NN cord-347946-i6kx3n6m 18 53 of of IN cord-347946-i6kx3n6m 18 54 MDD MDD NNP cord-347946-i6kx3n6m 18 55 . . . cord-347946-i6kx3n6m 19 1 From from IN cord-347946-i6kx3n6m 19 2 this this DT cord-347946-i6kx3n6m 19 3 perspective perspective NN cord-347946-i6kx3n6m 19 4 , , , cord-347946-i6kx3n6m 19 5 even even RB cord-347946-i6kx3n6m 19 6 environmental environmental JJ cord-347946-i6kx3n6m 19 7 risk risk NN cord-347946-i6kx3n6m 19 8 factors factor NNS cord-347946-i6kx3n6m 19 9 for for IN cord-347946-i6kx3n6m 19 10 depression depression NN cord-347946-i6kx3n6m 19 11 , , , cord-347946-i6kx3n6m 19 12 such such JJ cord-347946-i6kx3n6m 19 13 as as IN cord-347946-i6kx3n6m 19 14 psychosocial psychosocial JJ cord-347946-i6kx3n6m 19 15 stress stress NN cord-347946-i6kx3n6m 19 16 , , , cord-347946-i6kx3n6m 19 17 promote promote VB cord-347946-i6kx3n6m 19 18 MDD MDD NNP cord-347946-i6kx3n6m 19 19 primarily primarily RB cord-347946-i6kx3n6m 19 20 because because IN cord-347946-i6kx3n6m 19 21 across across IN cord-347946-i6kx3n6m 19 22 evolutionary evolutionary JJ cord-347946-i6kx3n6m 19 23 time time NN cord-347946-i6kx3n6m 19 24 these these DT cord-347946-i6kx3n6m 19 25 adversities adversity NNS cord-347946-i6kx3n6m 19 26 reliably reliably RB cord-347946-i6kx3n6m 19 27 served serve VBD cord-347946-i6kx3n6m 19 28 as as IN cord-347946-i6kx3n6m 19 29 warnings warning NNS cord-347946-i6kx3n6m 19 30 that that IN cord-347946-i6kx3n6m 19 31 an an DT cord-347946-i6kx3n6m 19 32 individual individual NN cord-347946-i6kx3n6m 19 33 's 's POS cord-347946-i6kx3n6m 19 34 risk risk NN cord-347946-i6kx3n6m 19 35 for for IN cord-347946-i6kx3n6m 19 36 infectious infectious JJ cord-347946-i6kx3n6m 19 37 morbidity/ morbidity/ CD cord-347946-i6kx3n6m 19 38 mortality mortality NN cord-347946-i6kx3n6m 19 39 were be VBD cord-347946-i6kx3n6m 19 40 heightened heighten VBN cord-347946-i6kx3n6m 19 41 . . . cord-347946-i6kx3n6m 20 1 Although although IN cord-347946-i6kx3n6m 20 2 this this DT cord-347946-i6kx3n6m 20 3 perspective perspective NN cord-347946-i6kx3n6m 20 4 may may MD cord-347946-i6kx3n6m 20 5 be be VB cord-347946-i6kx3n6m 20 6 most most RBS cord-347946-i6kx3n6m 20 7 relevant relevant JJ cord-347946-i6kx3n6m 20 8 to to IN cord-347946-i6kx3n6m 20 9 sub sub NN cord-347946-i6kx3n6m 20 10 - - NNS cord-347946-i6kx3n6m 20 11 types type NNS cord-347946-i6kx3n6m 20 12 of of IN cord-347946-i6kx3n6m 20 13 depression depression NN cord-347946-i6kx3n6m 20 14 associated associate VBN cord-347946-i6kx3n6m 20 15 with with IN cord-347946-i6kx3n6m 20 16 increased increase VBN cord-347946-i6kx3n6m 20 17 inflammation inflammation NN cord-347946-i6kx3n6m 20 18 , , , cord-347946-i6kx3n6m 20 19 we -PRON- PRP cord-347946-i6kx3n6m 20 20 highlight highlight VBP cord-347946-i6kx3n6m 20 21 in in IN cord-347946-i6kx3n6m 20 22 this this DT cord-347946-i6kx3n6m 20 23 review review NN cord-347946-i6kx3n6m 20 24 the the DT cord-347946-i6kx3n6m 20 25 possibility possibility NN cord-347946-i6kx3n6m 20 26 that that IN cord-347946-i6kx3n6m 20 27 other other JJ cord-347946-i6kx3n6m 20 28 immune immune NN cord-347946-i6kx3n6m 20 29 and/or and/or CC cord-347946-i6kx3n6m 20 30 behavioral behavioral JJ cord-347946-i6kx3n6m 20 31 responses response NNS cord-347946-i6kx3n6m 20 32 relevant relevant JJ cord-347946-i6kx3n6m 20 33 to to IN cord-347946-i6kx3n6m 20 34 pathogen pathogen NN cord-347946-i6kx3n6m 20 35 - - HYPH cord-347946-i6kx3n6m 20 36 host host NN cord-347946-i6kx3n6m 20 37 defense defense NN cord-347946-i6kx3n6m 20 38 may may MD cord-347946-i6kx3n6m 20 39 also also RB cord-347946-i6kx3n6m 20 40 be be VB cord-347946-i6kx3n6m 20 41 associated associate VBN cord-347946-i6kx3n6m 20 42 with with IN cord-347946-i6kx3n6m 20 43 MDD MDD NNP cord-347946-i6kx3n6m 20 44 in in IN cord-347946-i6kx3n6m 20 45 ways way NNS cord-347946-i6kx3n6m 20 46 that that WDT cord-347946-i6kx3n6m 20 47 extend extend VBP cord-347946-i6kx3n6m 20 48 the the DT cord-347946-i6kx3n6m 20 49 role role NN cord-347946-i6kx3n6m 20 50 of of IN cord-347946-i6kx3n6m 20 51 microbial microbial JJ cord-347946-i6kx3n6m 20 52 - - HYPH cord-347946-i6kx3n6m 20 53 human human JJ cord-347946-i6kx3n6m 20 54 interactions interaction NNS cord-347946-i6kx3n6m 20 55 in in IN cord-347946-i6kx3n6m 20 56 the the DT cord-347946-i6kx3n6m 20 57 evolution evolution NN cord-347946-i6kx3n6m 20 58 of of IN cord-347946-i6kx3n6m 20 59 depression depression NN cord-347946-i6kx3n6m 20 60 beyond beyond IN cord-347946-i6kx3n6m 20 61 its -PRON- PRP$ cord-347946-i6kx3n6m 20 62 now now RB cord-347946-i6kx3n6m 20 63 well well RB cord-347946-i6kx3n6m 20 64 - - HYPH cord-347946-i6kx3n6m 20 65 recognized recognize VBN cord-347946-i6kx3n6m 20 66 associations association NNS cord-347946-i6kx3n6m 20 67 with with IN cord-347946-i6kx3n6m 20 68 inflammation inflammation NN cord-347946-i6kx3n6m 20 69 . . . cord-347946-i6kx3n6m 21 1 Consistent consistent JJ cord-347946-i6kx3n6m 21 2 with with IN cord-347946-i6kx3n6m 21 3 earlier early JJR cord-347946-i6kx3n6m 21 4 publications publication NNS cord-347946-i6kx3n6m 21 5 from from IN cord-347946-i6kx3n6m 21 6 our -PRON- PRP$ cord-347946-i6kx3n6m 21 7 group group NN cord-347946-i6kx3n6m 21 8 Miller Miller NNP cord-347946-i6kx3n6m 21 9 , , , cord-347946-i6kx3n6m 21 10 2012 2012 CD cord-347946-i6kx3n6m 21 11 , , , cord-347946-i6kx3n6m 21 12 2013 2013 CD cord-347946-i6kx3n6m 21 13 ; ; : cord-347946-i6kx3n6m 21 14 Miller Miller NNP cord-347946-i6kx3n6m 21 15 and and CC cord-347946-i6kx3n6m 21 16 Raison Raison NNP cord-347946-i6kx3n6m 21 17 , , , cord-347946-i6kx3n6m 21 18 2015 2015 CD cord-347946-i6kx3n6m 21 19 ) ) -RRB- cord-347946-i6kx3n6m 21 20 , , , cord-347946-i6kx3n6m 21 21 we -PRON- PRP cord-347946-i6kx3n6m 21 22 refer refer VBP cord-347946-i6kx3n6m 21 23 to to IN cord-347946-i6kx3n6m 21 24 this this DT cord-347946-i6kx3n6m 21 25 constellation constellation NN cord-347946-i6kx3n6m 21 26 of of IN cord-347946-i6kx3n6m 21 27 ideas idea NNS cord-347946-i6kx3n6m 21 28 as as IN cord-347946-i6kx3n6m 21 29 the the DT cord-347946-i6kx3n6m 21 30 pathogen pathogen NN cord-347946-i6kx3n6m 21 31 - - HYPH cord-347946-i6kx3n6m 21 32 host host NN cord-347946-i6kx3n6m 21 33 defense defense NN cord-347946-i6kx3n6m 21 34 theory theory NN cord-347946-i6kx3n6m 21 35 of of IN cord-347946-i6kx3n6m 21 36 depression depression NN cord-347946-i6kx3n6m 21 37 , , , cord-347946-i6kx3n6m 21 38 or or CC cord-347946-i6kx3n6m 21 39 PATHOS PATHOS NNP cord-347946-i6kx3n6m 21 40 - - HYPH cord-347946-i6kx3n6m 21 41 D. D. NNP cord-347946-i6kx3n6m 22 1 This this DT cord-347946-i6kx3n6m 22 2 position position NN cord-347946-i6kx3n6m 22 3 overlaps overlap VBZ cord-347946-i6kx3n6m 22 4 , , , cord-347946-i6kx3n6m 22 5 but but CC cord-347946-i6kx3n6m 22 6 has have VBZ cord-347946-i6kx3n6m 22 7 significant significant JJ cord-347946-i6kx3n6m 22 8 differences difference NNS cord-347946-i6kx3n6m 22 9 from from IN cord-347946-i6kx3n6m 22 10 a a DT cord-347946-i6kx3n6m 22 11 pathogen pathogen NN cord-347946-i6kx3n6m 22 12 defense defense NN cord-347946-i6kx3n6m 22 13 theory theory NN cord-347946-i6kx3n6m 22 14 of of IN cord-347946-i6kx3n6m 22 15 depression depression NN cord-347946-i6kx3n6m 22 16 first first RB cord-347946-i6kx3n6m 22 17 articulated articulate VBN cord-347946-i6kx3n6m 22 18 by by IN cord-347946-i6kx3n6m 22 19 Kinney Kinney NNP cord-347946-i6kx3n6m 22 20 and and CC cord-347946-i6kx3n6m 22 21 Tanaka Tanaka NNP cord-347946-i6kx3n6m 22 22 , , , cord-347946-i6kx3n6m 22 23 ( ( -LRB- cord-347946-i6kx3n6m 22 24 2009 2009 CD cord-347946-i6kx3n6m 22 25 ) ) -RRB- cord-347946-i6kx3n6m 23 1 ( ( -LRB- cord-347946-i6kx3n6m 23 2 Anders Anders NNP cord-347946-i6kx3n6m 23 3 et et NNP cord-347946-i6kx3n6m 23 4 al al NNP cord-347946-i6kx3n6m 23 5 , , , cord-347946-i6kx3n6m 23 6 2013 2013 CD cord-347946-i6kx3n6m 23 7 ) ) -RRB- cord-347946-i6kx3n6m 23 8 . . . cord-347946-i6kx3n6m 24 1 Table table NN cord-347946-i6kx3n6m 24 2 1 1 CD cord-347946-i6kx3n6m 24 3 situates situate VBZ cord-347946-i6kx3n6m 24 4 PATHOS pathos NN cord-347946-i6kx3n6m 24 5 - - HYPH cord-347946-i6kx3n6m 24 6 D D NNP cord-347946-i6kx3n6m 24 7 within within IN cord-347946-i6kx3n6m 24 8 other other JJ cord-347946-i6kx3n6m 24 9 possible possible JJ cord-347946-i6kx3n6m 24 10 explanatory explanatory JJ cord-347946-i6kx3n6m 24 11 frameworks framework NNS cord-347946-i6kx3n6m 24 12 for for IN cord-347946-i6kx3n6m 24 13 understanding understanding NN cord-347946-i6kx3n6m 24 14 why why WRB cord-347946-i6kx3n6m 24 15 MDD MDD NNP cord-347946-i6kx3n6m 24 16 and and CC cord-347946-i6kx3n6m 24 17 alterations alteration NNS cord-347946-i6kx3n6m 24 18 in in IN cord-347946-i6kx3n6m 24 19 immune immune JJ cord-347946-i6kx3n6m 24 20 function function NN cord-347946-i6kx3n6m 24 21 should should MD cord-347946-i6kx3n6m 24 22 be be VB cord-347946-i6kx3n6m 24 23 related relate VBN cord-347946-i6kx3n6m 24 24 . . . cord-347946-i6kx3n6m 25 1 Supplementary supplementary JJ cord-347946-i6kx3n6m 25 2 Table Table NNP cord-347946-i6kx3n6m 25 3 S1 S1 NNP cord-347946-i6kx3n6m 25 4 provides provide VBZ cord-347946-i6kx3n6m 25 5 a a DT cord-347946-i6kx3n6m 25 6 comparison comparison NN cord-347946-i6kx3n6m 25 7 of of IN cord-347946-i6kx3n6m 25 8 different different JJ cord-347946-i6kx3n6m 25 9 adaptive adaptive JJ cord-347946-i6kx3n6m 25 10 explanations explanation NNS cord-347946-i6kx3n6m 25 11 for for IN cord-347946-i6kx3n6m 25 12 the the DT cord-347946-i6kx3n6m 25 13 persistence persistence NN cord-347946-i6kx3n6m 25 14 of of IN cord-347946-i6kx3n6m 25 15 MDD MDD NNP cord-347946-i6kx3n6m 25 16 and and CC cord-347946-i6kx3n6m 25 17 its -PRON- PRP$ cord-347946-i6kx3n6m 25 18 risk risk NN cord-347946-i6kx3n6m 25 19 alleles allele NNS cord-347946-i6kx3n6m 25 20 in in IN cord-347946-i6kx3n6m 25 21 human human JJ cord-347946-i6kx3n6m 25 22 populations population NNS cord-347946-i6kx3n6m 25 23 . . . cord-347946-i6kx3n6m 26 1 As as IN cord-347946-i6kx3n6m 26 2 with with IN cord-347946-i6kx3n6m 26 3 all all DT cord-347946-i6kx3n6m 26 4 theories theory NNS cord-347946-i6kx3n6m 26 5 , , , cord-347946-i6kx3n6m 26 6 the the DT cord-347946-i6kx3n6m 26 7 value value NN cord-347946-i6kx3n6m 26 8 of of IN cord-347946-i6kx3n6m 26 9 PATHOS pathos NN cord-347946-i6kx3n6m 26 10 - - HYPH cord-347946-i6kx3n6m 26 11 D D NNP cord-347946-i6kx3n6m 26 12 will will MD cord-347946-i6kx3n6m 26 13 eventually eventually RB cord-347946-i6kx3n6m 26 14 be be VB cord-347946-i6kx3n6m 26 15 determined determine VBN cord-347946-i6kx3n6m 26 16 by by IN cord-347946-i6kx3n6m 26 17 its -PRON- PRP$ cord-347946-i6kx3n6m 26 18 ability ability NN cord-347946-i6kx3n6m 26 19 to to TO cord-347946-i6kx3n6m 26 20 make make VB cord-347946-i6kx3n6m 26 21 novel novel JJ cord-347946-i6kx3n6m 26 22 predictions prediction NNS cord-347946-i6kx3n6m 26 23 and and CC cord-347946-i6kx3n6m 26 24 to to TO cord-347946-i6kx3n6m 26 25 provide provide VB cord-347946-i6kx3n6m 26 26 coherent coherent JJ cord-347946-i6kx3n6m 26 27 and and CC cord-347946-i6kx3n6m 26 28 parsimonious parsimonious JJ cord-347946-i6kx3n6m 26 29 explanations explanation NNS cord-347946-i6kx3n6m 26 30 for for IN cord-347946-i6kx3n6m 26 31 a a DT cord-347946-i6kx3n6m 26 32 wider wide JJR cord-347946-i6kx3n6m 26 33 range range NN cord-347946-i6kx3n6m 26 34 of of IN cord-347946-i6kx3n6m 26 35 variables variable NNS cord-347946-i6kx3n6m 26 36 than than IN cord-347946-i6kx3n6m 26 37 are be VBP cord-347946-i6kx3n6m 26 38 accounted account VBN cord-347946-i6kx3n6m 26 39 for for IN cord-347946-i6kx3n6m 26 40 by by IN cord-347946-i6kx3n6m 26 41 competing compete VBG cord-347946-i6kx3n6m 26 42 hypotheses hypothesis NNS cord-347946-i6kx3n6m 26 43 . . . cord-347946-i6kx3n6m 27 1 Our -PRON- PRP$ cord-347946-i6kx3n6m 27 2 aim aim NN cord-347946-i6kx3n6m 27 3 in in IN cord-347946-i6kx3n6m 27 4 this this DT cord-347946-i6kx3n6m 27 5 review review NN cord-347946-i6kx3n6m 27 6 is be VBZ cord-347946-i6kx3n6m 27 7 to to TO cord-347946-i6kx3n6m 27 8 evaluate evaluate VB cord-347946-i6kx3n6m 27 9 PATHOS pathos NN cord-347946-i6kx3n6m 27 10 - - HYPH cord-347946-i6kx3n6m 27 11 D d NN cord-347946-i6kx3n6m 27 12 by by IN cord-347946-i6kx3n6m 27 13 these these DT cord-347946-i6kx3n6m 27 14 criteria criterion NNS cord-347946-i6kx3n6m 27 15 . . . cord-347946-i6kx3n6m 28 1 To to TO cord-347946-i6kx3n6m 28 2 do do VB cord-347946-i6kx3n6m 28 3 this this DT cord-347946-i6kx3n6m 28 4 , , , cord-347946-i6kx3n6m 28 5 we -PRON- PRP cord-347946-i6kx3n6m 28 6 list list VBP cord-347946-i6kx3n6m 28 7 a a DT cord-347946-i6kx3n6m 28 8 series series NN cord-347946-i6kx3n6m 28 9 of of IN cord-347946-i6kx3n6m 28 10 concepts concept NNS cord-347946-i6kx3n6m 28 11 consistent consistent JJ cord-347946-i6kx3n6m 28 12 with with IN cord-347946-i6kx3n6m 28 13 PATHOS pathos NN cord-347946-i6kx3n6m 28 14 - - HYPH cord-347946-i6kx3n6m 28 15 D d JJ cord-347946-i6kx3n6m 28 16 theory theory NN cord-347946-i6kx3n6m 28 17 , , , cord-347946-i6kx3n6m 28 18 in in IN cord-347946-i6kx3n6m 28 19 each each DT cord-347946-i6kx3n6m 28 20 case case NN cord-347946-i6kx3n6m 28 21 evaluating evaluate VBG cord-347946-i6kx3n6m 28 22 the the DT cord-347946-i6kx3n6m 28 23 evidence evidence NN cord-347946-i6kx3n6m 28 24 for for IN cord-347946-i6kx3n6m 28 25 and and CC cord-347946-i6kx3n6m 28 26 against against IN cord-347946-i6kx3n6m 28 27 the the DT cord-347946-i6kx3n6m 28 28 theory theory NN cord-347946-i6kx3n6m 28 29 's 's POS cord-347946-i6kx3n6m 28 30 explanatory explanatory JJ cord-347946-i6kx3n6m 28 31 and and CC cord-347946-i6kx3n6m 28 32 predictive predictive JJ cord-347946-i6kx3n6m 28 33 potential potential NN cord-347946-i6kx3n6m 28 34 . . . cord-347946-i6kx3n6m 29 1 In in IN cord-347946-i6kx3n6m 29 2 addition addition NN cord-347946-i6kx3n6m 29 3 , , , cord-347946-i6kx3n6m 29 4 we -PRON- PRP cord-347946-i6kx3n6m 29 5 explore explore VBP cord-347946-i6kx3n6m 29 6 the the DT cord-347946-i6kx3n6m 29 7 theory theory NN cord-347946-i6kx3n6m 29 8 's 's POS cord-347946-i6kx3n6m 29 9 possible possible JJ cord-347946-i6kx3n6m 29 10 explanations explanation NNS cord-347946-i6kx3n6m 29 11 for for IN cord-347946-i6kx3n6m 29 12 sex sex NN cord-347946-i6kx3n6m 29 13 differences difference NNS cord-347946-i6kx3n6m 29 14 in in IN cord-347946-i6kx3n6m 29 15 the the DT cord-347946-i6kx3n6m 29 16 prevalence prevalence NN cord-347946-i6kx3n6m 29 17 of of IN cord-347946-i6kx3n6m 29 18 MDD MDD NNP cord-347946-i6kx3n6m 29 19 . . . cord-347946-i6kx3n6m 30 1 In in IN cord-347946-i6kx3n6m 30 2 all all PDT cord-347946-i6kx3n6m 30 3 these these DT cord-347946-i6kx3n6m 30 4 areas area NNS cord-347946-i6kx3n6m 30 5 , , , cord-347946-i6kx3n6m 30 6 we -PRON- PRP cord-347946-i6kx3n6m 30 7 are be VBP cord-347946-i6kx3n6m 30 8 careful careful JJ cord-347946-i6kx3n6m 30 9 to to TO cord-347946-i6kx3n6m 30 10 note note VB cord-347946-i6kx3n6m 30 11 the the DT cord-347946-i6kx3n6m 30 12 degree degree NN cord-347946-i6kx3n6m 30 13 of of IN cord-347946-i6kx3n6m 30 14 data datum NNS cord-347946-i6kx3n6m 30 15 in in IN cord-347946-i6kx3n6m 30 16 support support NN cord-347946-i6kx3n6m 30 17 of of IN cord-347946-i6kx3n6m 30 18 each each DT cord-347946-i6kx3n6m 30 19 idea idea NN cord-347946-i6kx3n6m 30 20 , , , cord-347946-i6kx3n6m 30 21 and and CC cord-347946-i6kx3n6m 30 22 which which WDT cord-347946-i6kx3n6m 30 23 ideas idea NNS cord-347946-i6kx3n6m 30 24 are be VBP cord-347946-i6kx3n6m 30 25 frankly frankly RB cord-347946-i6kx3n6m 30 26 speculative speculative JJ cord-347946-i6kx3n6m 30 27 . . . cord-347946-i6kx3n6m 31 1 Figure figure NN cord-347946-i6kx3n6m 31 2 1 1 CD cord-347946-i6kx3n6m 31 3 provides provide VBZ cord-347946-i6kx3n6m 31 4 a a DT cord-347946-i6kx3n6m 31 5 graphic graphic JJ cord-347946-i6kx3n6m 31 6 representation representation NN cord-347946-i6kx3n6m 31 7 of of IN cord-347946-i6kx3n6m 31 8 epidemiological epidemiological JJ cord-347946-i6kx3n6m 31 9 , , , cord-347946-i6kx3n6m 31 10 biological biological JJ cord-347946-i6kx3n6m 31 11 , , , cord-347946-i6kx3n6m 31 12 and and CC cord-347946-i6kx3n6m 31 13 genetic genetic JJ cord-347946-i6kx3n6m 31 14 domains domain NNS cord-347946-i6kx3n6m 31 15 relevant relevant JJ cord-347946-i6kx3n6m 31 16 to to IN cord-347946-i6kx3n6m 31 17 MDD MDD NNP cord-347946-i6kx3n6m 31 18 that that WDT cord-347946-i6kx3n6m 31 19 are be VBP cord-347946-i6kx3n6m 31 20 addressed address VBN cord-347946-i6kx3n6m 31 21 by by IN cord-347946-i6kx3n6m 31 22 PATHOS PATHOS NNP cord-347946-i6kx3n6m 31 23 - - HYPH cord-347946-i6kx3n6m 31 24 D. D. NNP cord-347946-i6kx3n6m 31 25 Of of IN cord-347946-i6kx3n6m 31 26 all all PDT cord-347946-i6kx3n6m 31 27 the the DT cord-347946-i6kx3n6m 31 28 predictions prediction NNS cord-347946-i6kx3n6m 31 29 of of IN cord-347946-i6kx3n6m 31 30 PATHOS pathos NN cord-347946-i6kx3n6m 31 31 - - HYPH cord-347946-i6kx3n6m 31 32 D D NNP cord-347946-i6kx3n6m 31 33 , , , cord-347946-i6kx3n6m 31 34 this this DT cord-347946-i6kx3n6m 31 35 one one NN cord-347946-i6kx3n6m 31 36 is be VBZ cord-347946-i6kx3n6m 31 37 the the DT cord-347946-i6kx3n6m 31 38 best well RBS cord-347946-i6kx3n6m 31 39 established establish VBN cord-347946-i6kx3n6m 31 40 . . . cord-347946-i6kx3n6m 32 1 Indeed indeed RB cord-347946-i6kx3n6m 32 2 , , , cord-347946-i6kx3n6m 32 3 it -PRON- PRP cord-347946-i6kx3n6m 32 4 was be VBD cord-347946-i6kx3n6m 32 5 the the DT cord-347946-i6kx3n6m 32 6 effort effort NN cord-347946-i6kx3n6m 32 7 to to TO cord-347946-i6kx3n6m 32 8 provide provide VB cord-347946-i6kx3n6m 32 9 an an DT cord-347946-i6kx3n6m 32 10 evolutionary evolutionary JJ cord-347946-i6kx3n6m 32 11 perspective perspective NN cord-347946-i6kx3n6m 32 12 on on IN cord-347946-i6kx3n6m 32 13 the the DT cord-347946-i6kx3n6m 32 14 association association NN cord-347946-i6kx3n6m 32 15 between between IN cord-347946-i6kx3n6m 32 16 inflammation inflammation NN cord-347946-i6kx3n6m 32 17 and and CC cord-347946-i6kx3n6m 32 18 depression depression NN cord-347946-i6kx3n6m 32 19 that that WDT cord-347946-i6kx3n6m 32 20 provided provide VBD cord-347946-i6kx3n6m 32 21 the the DT cord-347946-i6kx3n6m 32 22 initial initial JJ cord-347946-i6kx3n6m 32 23 impetus impetus NN cord-347946-i6kx3n6m 32 24 for for IN cord-347946-i6kx3n6m 32 25 the the DT cord-347946-i6kx3n6m 32 26 theory theory NN cord-347946-i6kx3n6m 32 27 . . . cord-347946-i6kx3n6m 33 1 Taken take VBN cord-347946-i6kx3n6m 33 2 as as IN cord-347946-i6kx3n6m 33 3 a a DT cord-347946-i6kx3n6m 33 4 whole whole NN cord-347946-i6kx3n6m 33 5 , , , cord-347946-i6kx3n6m 33 6 studies study NNS cord-347946-i6kx3n6m 33 7 suggest suggest VBP cord-347946-i6kx3n6m 33 8 that that IN cord-347946-i6kx3n6m 33 9 MDD MDD NNP cord-347946-i6kx3n6m 33 10 is be VBZ cord-347946-i6kx3n6m 33 11 associated associate VBN cord-347946-i6kx3n6m 33 12 with with IN cord-347946-i6kx3n6m 33 13 all all PDT cord-347946-i6kx3n6m 33 14 the the DT cord-347946-i6kx3n6m 33 15 cardinal cardinal JJ cord-347946-i6kx3n6m 33 16 features feature NNS cord-347946-i6kx3n6m 33 17 of of IN cord-347946-i6kx3n6m 33 18 an an DT cord-347946-i6kx3n6m 33 19 inflammatory inflammatory JJ cord-347946-i6kx3n6m 33 20 response response NN cord-347946-i6kx3n6m 33 21 including include VBG cord-347946-i6kx3n6m 33 22 increased increase VBN cord-347946-i6kx3n6m 33 23 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 33 24 cytokines cytokine NNS cord-347946-i6kx3n6m 33 25 and and CC cord-347946-i6kx3n6m 33 26 their -PRON- PRP$ cord-347946-i6kx3n6m 33 27 receptors receptor NNS cord-347946-i6kx3n6m 33 28 and and CC cord-347946-i6kx3n6m 33 29 increased increase VBN cord-347946-i6kx3n6m 33 30 acute acute JJ cord-347946-i6kx3n6m 33 31 phase phase NN cord-347946-i6kx3n6m 33 32 reactants reactant NNS cord-347946-i6kx3n6m 33 33 , , , cord-347946-i6kx3n6m 33 34 chemokines chemokine NNS cord-347946-i6kx3n6m 33 35 , , , cord-347946-i6kx3n6m 33 36 and and CC cord-347946-i6kx3n6m 33 37 soluble soluble JJ cord-347946-i6kx3n6m 33 38 adhesion adhesion NN cord-347946-i6kx3n6m 33 39 molecules molecule NNS cord-347946-i6kx3n6m 33 40 in in IN cord-347946-i6kx3n6m 33 41 peripheral peripheral JJ cord-347946-i6kx3n6m 33 42 blood blood NN cord-347946-i6kx3n6m 33 43 ( ( -LRB- cord-347946-i6kx3n6m 33 44 Lieb Lieb NNP cord-347946-i6kx3n6m 33 45 et et NNP cord-347946-i6kx3n6m 33 46 al al NNP cord-347946-i6kx3n6m 33 47 , , , cord-347946-i6kx3n6m 33 48 1983 1983 CD cord-347946-i6kx3n6m 33 49 ; ; : cord-347946-i6kx3n6m 33 50 Calabrese Calabrese NNP cord-347946-i6kx3n6m 33 51 et et NNP cord-347946-i6kx3n6m 33 52 al al NNP cord-347946-i6kx3n6m 33 53 , , , cord-347946-i6kx3n6m 33 54 1986 1986 CD cord-347946-i6kx3n6m 33 55 ; ; : cord-347946-i6kx3n6m 33 56 Sluzewska Sluzewska NNP cord-347946-i6kx3n6m 33 57 et et FW cord-347946-i6kx3n6m 33 58 al al NNP cord-347946-i6kx3n6m 33 59 , , , cord-347946-i6kx3n6m 33 60 1996 1996 CD cord-347946-i6kx3n6m 33 61 ; ; : cord-347946-i6kx3n6m 33 62 Song Song NNP cord-347946-i6kx3n6m 33 63 et et FW cord-347946-i6kx3n6m 33 64 al al NNP cord-347946-i6kx3n6m 33 65 , , , cord-347946-i6kx3n6m 33 66 1998 1998 CD cord-347946-i6kx3n6m 33 67 ; ; : cord-347946-i6kx3n6m 33 68 Howren Howren NNP cord-347946-i6kx3n6m 33 69 et et NNP cord-347946-i6kx3n6m 33 70 al al NNP cord-347946-i6kx3n6m 33 71 , , , cord-347946-i6kx3n6m 33 72 2009 2009 CD cord-347946-i6kx3n6m 33 73 ; ; : cord-347946-i6kx3n6m 33 74 Dowlati Dowlati NNP cord-347946-i6kx3n6m 33 75 et et FW cord-347946-i6kx3n6m 33 76 al al NNP cord-347946-i6kx3n6m 33 77 , , , cord-347946-i6kx3n6m 33 78 2010 2010 CD cord-347946-i6kx3n6m 33 79 ; ; : cord-347946-i6kx3n6m 33 80 Liu Liu NNP cord-347946-i6kx3n6m 33 81 et et NNP cord-347946-i6kx3n6m 33 82 al al NNP cord-347946-i6kx3n6m 33 83 , , , cord-347946-i6kx3n6m 33 84 2012b 2012b CD cord-347946-i6kx3n6m 33 85 ; ; : cord-347946-i6kx3n6m 33 86 Valkanova Valkanova NNP cord-347946-i6kx3n6m 33 87 et et NNP cord-347946-i6kx3n6m 33 88 al al NNP cord-347946-i6kx3n6m 33 89 , , , cord-347946-i6kx3n6m 33 90 2013 2013 CD cord-347946-i6kx3n6m 33 91 ; ; : cord-347946-i6kx3n6m 34 1 Black Black NNP cord-347946-i6kx3n6m 34 2 and and CC cord-347946-i6kx3n6m 34 3 Miller Miller NNP cord-347946-i6kx3n6m 34 4 , , , cord-347946-i6kx3n6m 34 5 2015 2015 CD cord-347946-i6kx3n6m 34 6 ; ; : cord-347946-i6kx3n6m 34 7 Haapakoski Haapakoski NNP cord-347946-i6kx3n6m 34 8 et et NNP cord-347946-i6kx3n6m 34 9 al al NNP cord-347946-i6kx3n6m 34 10 , , , cord-347946-i6kx3n6m 34 11 2015 2015 CD cord-347946-i6kx3n6m 34 12 ; ; : cord-347946-i6kx3n6m 34 13 Eyre Eyre NNP cord-347946-i6kx3n6m 34 14 et et NNP cord-347946-i6kx3n6m 34 15 al al NNP cord-347946-i6kx3n6m 34 16 , , , cord-347946-i6kx3n6m 34 17 2016 2016 CD cord-347946-i6kx3n6m 34 18 ; ; : cord-347946-i6kx3n6m 34 19 Goldsmith Goldsmith NNP cord-347946-i6kx3n6m 34 20 et et NNP cord-347946-i6kx3n6m 34 21 al al NNP cord-347946-i6kx3n6m 34 22 , , , cord-347946-i6kx3n6m 34 23 2016b 2016b CD cord-347946-i6kx3n6m 34 24 ; ; : cord-347946-i6kx3n6m 34 25 van van NNP cord-347946-i6kx3n6m 34 26 Dooren Dooren NNP cord-347946-i6kx3n6m 34 27 et et NNP cord-347946-i6kx3n6m 34 28 al al NNP cord-347946-i6kx3n6m 34 29 , , , cord-347946-i6kx3n6m 34 30 2016 2016 CD cord-347946-i6kx3n6m 34 31 ) ) -RRB- cord-347946-i6kx3n6m 34 32 . . . cord-347946-i6kx3n6m 35 1 Several several JJ cord-347946-i6kx3n6m 35 2 studies study NNS cord-347946-i6kx3n6m 35 3 provide provide VBP cord-347946-i6kx3n6m 35 4 evidence evidence NN cord-347946-i6kx3n6m 35 5 of of IN cord-347946-i6kx3n6m 35 6 increased increase VBN cord-347946-i6kx3n6m 35 7 inflammatory inflammatory JJ cord-347946-i6kx3n6m 35 8 activity activity NN cord-347946-i6kx3n6m 35 9 in in IN cord-347946-i6kx3n6m 35 10 the the DT cord-347946-i6kx3n6m 35 11 central central JJ cord-347946-i6kx3n6m 35 12 nervous nervous JJ cord-347946-i6kx3n6m 35 13 system system NN cord-347946-i6kx3n6m 35 14 of of IN cord-347946-i6kx3n6m 35 15 depressed depressed JJ cord-347946-i6kx3n6m 35 16 individuals individual NNS cord-347946-i6kx3n6m 35 17 as as RB cord-347946-i6kx3n6m 35 18 well well RB cord-347946-i6kx3n6m 35 19 , , , cord-347946-i6kx3n6m 35 20 as as IN cord-347946-i6kx3n6m 35 21 indexed index VBN cord-347946-i6kx3n6m 35 22 by by IN cord-347946-i6kx3n6m 35 23 increased increase VBN cord-347946-i6kx3n6m 35 24 cerebrospinal cerebrospinal JJ cord-347946-i6kx3n6m 35 25 fluid fluid NN cord-347946-i6kx3n6m 35 26 ( ( -LRB- cord-347946-i6kx3n6m 35 27 CSF CSF NNP cord-347946-i6kx3n6m 35 28 ) ) -RRB- cord-347946-i6kx3n6m 35 29 concentrations concentration NNS cord-347946-i6kx3n6m 35 30 of of IN cord-347946-i6kx3n6m 35 31 interleukin interleukin NN cord-347946-i6kx3n6m 35 32 ( ( -LRB- cord-347946-i6kx3n6m 35 33 IL)-1-β il)-1-β JJ cord-347946-i6kx3n6m 35 34 and and CC cord-347946-i6kx3n6m 35 35 neural neural JJ cord-347946-i6kx3n6m 35 36 adhesion adhesion NN cord-347946-i6kx3n6m 35 37 molecules molecule NNS cord-347946-i6kx3n6m 35 38 , , , cord-347946-i6kx3n6m 35 39 as as RB cord-347946-i6kx3n6m 35 40 well well RB cord-347946-i6kx3n6m 35 41 as as IN cord-347946-i6kx3n6m 35 42 by by IN cord-347946-i6kx3n6m 35 43 increased increase VBN cord-347946-i6kx3n6m 35 44 prefrontal prefrontal JJ cord-347946-i6kx3n6m 35 45 cortex cortex NNP cord-347946-i6kx3n6m 35 46 gene gene NN cord-347946-i6kx3n6m 35 47 expression expression NN cord-347946-i6kx3n6m 35 48 of of IN cord-347946-i6kx3n6m 35 49 IL-1-α IL-1-α NNP cord-347946-i6kx3n6m 35 50 , , , cord-347946-i6kx3n6m 35 51 IL-2 IL-2 NNP cord-347946-i6kx3n6m 35 52 , , , cord-347946-i6kx3n6m 35 53 IL-3 IL-3 NNP cord-347946-i6kx3n6m 35 54 , , , cord-347946-i6kx3n6m 35 55 IL-5 IL-5 NNP cord-347946-i6kx3n6m 35 56 , , , cord-347946-i6kx3n6m 36 1 IL-8 IL-8 NNP cord-347946-i6kx3n6m 36 2 , , , cord-347946-i6kx3n6m 36 3 IL-9 IL-9 NNP cord-347946-i6kx3n6m 36 4 , , , cord-347946-i6kx3n6m 36 5 IL-10 IL-10 NNP cord-347946-i6kx3n6m 36 6 , , , cord-347946-i6kx3n6m 36 7 IL-12A IL-12A NNP cord-347946-i6kx3n6m 36 8 , , , cord-347946-i6kx3n6m 36 9 IL-13 IL-13 NNP cord-347946-i6kx3n6m 36 10 , , , cord-347946-i6kx3n6m 36 11 IL-15 IL-15 NNP cord-347946-i6kx3n6m 36 12 , , , cord-347946-i6kx3n6m 36 13 IL-18 IL-18 NNP cord-347946-i6kx3n6m 36 14 , , , cord-347946-i6kx3n6m 36 15 interferon interferon NN cord-347946-i6kx3n6m 36 16 ( ( -LRB- cord-347946-i6kx3n6m 36 17 IFN)-γ IFN)-γ NNP cord-347946-i6kx3n6m 36 18 , , , cord-347946-i6kx3n6m 36 19 and and CC cord-347946-i6kx3n6m 36 20 lymphotoxin lymphotoxin NNP cord-347946-i6kx3n6m 36 21 alpha alpha NNP cord-347946-i6kx3n6m 36 22 ( ( -LRB- cord-347946-i6kx3n6m 36 23 TNF TNF NNP cord-347946-i6kx3n6m 36 24 superfamily superfamily NN cord-347946-i6kx3n6m 36 25 member member NN cord-347946-i6kx3n6m 36 26 1 1 CD cord-347946-i6kx3n6m 36 27 ; ; : cord-347946-i6kx3n6m 36 28 Poltorak Poltorak NNP cord-347946-i6kx3n6m 36 29 et et NNP cord-347946-i6kx3n6m 36 30 al al NNP cord-347946-i6kx3n6m 36 31 , , , cord-347946-i6kx3n6m 36 32 1996 1996 CD cord-347946-i6kx3n6m 36 33 , , , cord-347946-i6kx3n6m 36 34 Levine Levine NNP cord-347946-i6kx3n6m 36 35 et et NNP cord-347946-i6kx3n6m 36 36 al al NNP cord-347946-i6kx3n6m 36 37 , , , cord-347946-i6kx3n6m 36 38 1999 1999 CD cord-347946-i6kx3n6m 36 39 Shelton Shelton NNP cord-347946-i6kx3n6m 36 40 et et NNP cord-347946-i6kx3n6m 36 41 al al NNP cord-347946-i6kx3n6m 36 42 , , , cord-347946-i6kx3n6m 36 43 2010 2010 CD cord-347946-i6kx3n6m 36 44 ) ) -RRB- cord-347946-i6kx3n6m 36 45 . . . cord-347946-i6kx3n6m 37 1 Perhaps perhaps RB cord-347946-i6kx3n6m 37 2 suggesting suggest VBG cord-347946-i6kx3n6m 37 3 a a DT cord-347946-i6kx3n6m 37 4 link link NN cord-347946-i6kx3n6m 37 5 between between IN cord-347946-i6kx3n6m 37 6 inflammation inflammation NN cord-347946-i6kx3n6m 37 7 and and CC cord-347946-i6kx3n6m 37 8 symptom symptom NN cord-347946-i6kx3n6m 37 9 acuity acuity NN cord-347946-i6kx3n6m 37 10 , , , cord-347946-i6kx3n6m 37 11 and/or and/or CC cord-347946-i6kx3n6m 37 12 reflecting reflect VBG cord-347946-i6kx3n6m 37 13 the the DT cord-347946-i6kx3n6m 37 14 association association NN cord-347946-i6kx3n6m 37 15 between between IN cord-347946-i6kx3n6m 37 16 inflammation inflammation NN cord-347946-i6kx3n6m 37 17 and and CC cord-347946-i6kx3n6m 37 18 heightened heightened JJ cord-347946-i6kx3n6m 37 19 anxiety anxiety NN cord-347946-i6kx3n6m 37 20 ( ( -LRB- cord-347946-i6kx3n6m 37 21 a a DT cord-347946-i6kx3n6m 37 22 known know VBN cord-347946-i6kx3n6m 37 23 suicide suicide NN cord-347946-i6kx3n6m 37 24 risk risk NN cord-347946-i6kx3n6m 37 25 ) ) -RRB- cord-347946-i6kx3n6m 37 26 , , , cord-347946-i6kx3n6m 37 27 a a DT cord-347946-i6kx3n6m 37 28 recent recent JJ cord-347946-i6kx3n6m 37 29 meta meta JJ cord-347946-i6kx3n6m 37 30 - - HYPH cord-347946-i6kx3n6m 37 31 analysis analysis NN cord-347946-i6kx3n6m 37 32 found find VBD cord-347946-i6kx3n6m 37 33 that that IN cord-347946-i6kx3n6m 37 34 levels level NNS cord-347946-i6kx3n6m 37 35 of of IN cord-347946-i6kx3n6m 37 36 IL-1-β IL-1-β NNP cord-347946-i6kx3n6m 37 37 and and CC cord-347946-i6kx3n6m 37 38 IL-6 IL-6 NNP cord-347946-i6kx3n6m 37 39 were be VBD cord-347946-i6kx3n6m 37 40 significantly significantly RB cord-347946-i6kx3n6m 37 41 increased increase VBN cord-347946-i6kx3n6m 37 42 in in IN cord-347946-i6kx3n6m 37 43 blood blood NN cord-347946-i6kx3n6m 37 44 and and CC cord-347946-i6kx3n6m 37 45 postmortem postmortem JJ cord-347946-i6kx3n6m 37 46 brain brain NN cord-347946-i6kx3n6m 37 47 samples sample NNS cord-347946-i6kx3n6m 37 48 of of IN cord-347946-i6kx3n6m 37 49 patients patient NNS cord-347946-i6kx3n6m 37 50 with with IN cord-347946-i6kx3n6m 37 51 suicidality suicidality NN cord-347946-i6kx3n6m 37 52 compared compare VBN cord-347946-i6kx3n6m 37 53 with with IN cord-347946-i6kx3n6m 37 54 both both DT cord-347946-i6kx3n6m 37 55 non non JJ cord-347946-i6kx3n6m 37 56 - - JJ cord-347946-i6kx3n6m 37 57 suicidal suicidal JJ cord-347946-i6kx3n6m 37 58 depressed depressed JJ cord-347946-i6kx3n6m 37 59 patients patient NNS cord-347946-i6kx3n6m 37 60 and and CC cord-347946-i6kx3n6m 37 61 healthy healthy JJ cord-347946-i6kx3n6m 37 62 control control NN cord-347946-i6kx3n6m 37 63 subjects subject NNS cord-347946-i6kx3n6m 37 64 ( ( -LRB- cord-347946-i6kx3n6m 37 65 Black Black NNP cord-347946-i6kx3n6m 37 66 and and CC cord-347946-i6kx3n6m 37 67 Miller Miller NNP cord-347946-i6kx3n6m 37 68 , , , cord-347946-i6kx3n6m 37 69 2015 2015 CD cord-347946-i6kx3n6m 37 70 ) ) -RRB- cord-347946-i6kx3n6m 37 71 . . . cord-347946-i6kx3n6m 38 1 Given give VBN cord-347946-i6kx3n6m 38 2 their -PRON- PRP$ cord-347946-i6kx3n6m 38 3 centrality centrality NN cord-347946-i6kx3n6m 38 4 in in IN cord-347946-i6kx3n6m 38 5 activating activate VBG cord-347946-i6kx3n6m 38 6 innate innate JJ cord-347946-i6kx3n6m 38 7 immune immune JJ cord-347946-i6kx3n6m 38 8 responses response NNS cord-347946-i6kx3n6m 38 9 to to IN cord-347946-i6kx3n6m 38 10 pathogens pathogen NNS cord-347946-i6kx3n6m 38 11 , , , cord-347946-i6kx3n6m 38 12 it -PRON- PRP cord-347946-i6kx3n6m 38 13 is be VBZ cord-347946-i6kx3n6m 38 14 striking strike VBG cord-347946-i6kx3n6m 38 15 that that IN cord-347946-i6kx3n6m 38 16 No no DT cord-347946-i6kx3n6m 38 17 adaptive adaptive JJ cord-347946-i6kx3n6m 38 18 relationship relationship NN cord-347946-i6kx3n6m 38 19 exists exist VBZ cord-347946-i6kx3n6m 38 20 between between IN cord-347946-i6kx3n6m 38 21 immune immune JJ cord-347946-i6kx3n6m 38 22 changes change NNS cord-347946-i6kx3n6m 38 23 and and CC cord-347946-i6kx3n6m 38 24 depressive depressive JJ cord-347946-i6kx3n6m 38 25 symptoms symptom NNS cord-347946-i6kx3n6m 38 26 . . . cord-347946-i6kx3n6m 39 1 Immune immune JJ cord-347946-i6kx3n6m 39 2 changes change NNS cord-347946-i6kx3n6m 39 3 observed observe VBN cord-347946-i6kx3n6m 39 4 in in IN cord-347946-i6kx3n6m 39 5 major major JJ cord-347946-i6kx3n6m 39 6 depressive depressive JJ cord-347946-i6kx3n6m 39 7 disorder disorder NN cord-347946-i6kx3n6m 39 8 ( ( -LRB- cord-347946-i6kx3n6m 39 9 MDD MDD NNP cord-347946-i6kx3n6m 39 10 ) ) -RRB- cord-347946-i6kx3n6m 39 11 may may MD cord-347946-i6kx3n6m 39 12 be be VB cord-347946-i6kx3n6m 39 13 beneficial beneficial JJ cord-347946-i6kx3n6m 39 14 or or CC cord-347946-i6kx3n6m 39 15 detrimental detrimental JJ cord-347946-i6kx3n6m 39 16 to to IN cord-347946-i6kx3n6m 39 17 pathogen pathogen NN cord-347946-i6kx3n6m 39 18 - - HYPH cord-347946-i6kx3n6m 39 19 host host NN cord-347946-i6kx3n6m 39 20 defense defense NN cord-347946-i6kx3n6m 39 21 and and CC cord-347946-i6kx3n6m 39 22 adaptive adaptive JJ cord-347946-i6kx3n6m 39 23 benefits benefit NNS cord-347946-i6kx3n6m 39 24 of of IN cord-347946-i6kx3n6m 39 25 depression depression NN cord-347946-i6kx3n6m 39 26 exist exist VBP cord-347946-i6kx3n6m 39 27 in in IN cord-347946-i6kx3n6m 39 28 non non JJ cord-347946-i6kx3n6m 39 29 - - JJ cord-347946-i6kx3n6m 39 30 pathogen pathogen JJ cord-347946-i6kx3n6m 39 31 / / SYM cord-347946-i6kx3n6m 39 32 immune immune NN cord-347946-i6kx3n6m 39 33 - - HYPH cord-347946-i6kx3n6m 39 34 related relate VBN cord-347946-i6kx3n6m 39 35 domains domain NNS cord-347946-i6kx3n6m 39 36 ( ( -LRB- cord-347946-i6kx3n6m 39 37 multiple multiple JJ cord-347946-i6kx3n6m 39 38 adaptive adaptive JJ cord-347946-i6kx3n6m 39 39 theories theory NNS cord-347946-i6kx3n6m 39 40 , , , cord-347946-i6kx3n6m 39 41 eg eg NN cord-347946-i6kx3n6m 39 42 , , , cord-347946-i6kx3n6m 39 43 social social JJ cord-347946-i6kx3n6m 39 44 navigation navigation NN cord-347946-i6kx3n6m 39 45 hypothesis hypothesis NN cord-347946-i6kx3n6m 39 46 ) ) -RRB- cord-347946-i6kx3n6m 40 1 Depressive depressive JJ cord-347946-i6kx3n6m 40 2 symptoms symptom NNS cord-347946-i6kx3n6m 40 3 extract extract VBP cord-347946-i6kx3n6m 40 4 a a DT cord-347946-i6kx3n6m 40 5 cost cost NN cord-347946-i6kx3n6m 40 6 to to IN cord-347946-i6kx3n6m 40 7 survival survival NN cord-347946-i6kx3n6m 40 8 and and CC cord-347946-i6kx3n6m 40 9 reproduction reproduction NN cord-347946-i6kx3n6m 40 10 but but CC cord-347946-i6kx3n6m 40 11 this this DT cord-347946-i6kx3n6m 40 12 cost cost NN cord-347946-i6kx3n6m 40 13 is be VBZ cord-347946-i6kx3n6m 40 14 offset offset VBN cord-347946-i6kx3n6m 40 15 by by IN cord-347946-i6kx3n6m 40 16 the the DT cord-347946-i6kx3n6m 40 17 direct direct JJ cord-347946-i6kx3n6m 40 18 anti anti JJ cord-347946-i6kx3n6m 40 19 - - JJ cord-347946-i6kx3n6m 40 20 pathogen pathogen JJ cord-347946-i6kx3n6m 40 21 benefits benefit NNS cord-347946-i6kx3n6m 40 22 of of IN cord-347946-i6kx3n6m 40 23 heightened heightened JJ cord-347946-i6kx3n6m 40 24 inflammation inflammation NN cord-347946-i6kx3n6m 40 25 / / SYM cord-347946-i6kx3n6m 40 26 immune immune JJ cord-347946-i6kx3n6m 40 27 activation activation NN cord-347946-i6kx3n6m 40 28 ( ( -LRB- cord-347946-i6kx3n6m 40 29 antagonistic antagonistic JJ cord-347946-i6kx3n6m 40 30 pleiotropy pleiotropy NN cord-347946-i6kx3n6m 40 31 ) ) -RRB- cord-347946-i6kx3n6m 41 1 In in IN cord-347946-i6kx3n6m 41 2 individuals individual NNS cord-347946-i6kx3n6m 41 3 with with IN cord-347946-i6kx3n6m 41 4 reduced reduce VBN cord-347946-i6kx3n6m 41 5 immune immune JJ cord-347946-i6kx3n6m 41 6 competence competence NN cord-347946-i6kx3n6m 41 7 for for IN cord-347946-i6kx3n6m 41 8 any any DT cord-347946-i6kx3n6m 41 9 number number NN cord-347946-i6kx3n6m 41 10 of of IN cord-347946-i6kx3n6m 41 11 reasons reason NNS cord-347946-i6kx3n6m 41 12 , , , cord-347946-i6kx3n6m 41 13 depressive depressive JJ cord-347946-i6kx3n6m 41 14 symptoms symptom NNS cord-347946-i6kx3n6m 41 15 serve serve VBP cord-347946-i6kx3n6m 41 16 pathogen pathogen NN cord-347946-i6kx3n6m 41 17 - - HYPH cord-347946-i6kx3n6m 41 18 host host NN cord-347946-i6kx3n6m 41 19 defense defense NN cord-347946-i6kx3n6m 41 20 by by IN cord-347946-i6kx3n6m 41 21 inducing induce VBG cord-347946-i6kx3n6m 41 22 social social JJ cord-347946-i6kx3n6m 41 23 avoidance avoidance NN cord-347946-i6kx3n6m 41 24 / / SYM cord-347946-i6kx3n6m 41 25 energy energy NN cord-347946-i6kx3n6m 41 26 conservation conservation NN cord-347946-i6kx3n6m 41 27 and and CC cord-347946-i6kx3n6m 41 28 behaviors behavior NNS cord-347946-i6kx3n6m 41 29 that that WDT cord-347946-i6kx3n6m 41 30 provide provide VBP cord-347946-i6kx3n6m 41 31 protection protection NN cord-347946-i6kx3n6m 41 32 from from IN cord-347946-i6kx3n6m 41 33 becoming become VBG cord-347946-i6kx3n6m 41 34 infected infect VBN cord-347946-i6kx3n6m 41 35 and/or and/or CC cord-347946-i6kx3n6m 41 36 energy energy NN cord-347946-i6kx3n6m 41 37 for for IN cord-347946-i6kx3n6m 41 38 immune immune JJ cord-347946-i6kx3n6m 41 39 activity activity NN cord-347946-i6kx3n6m 41 40 once once IN cord-347946-i6kx3n6m 41 41 infection infection NN cord-347946-i6kx3n6m 41 42 has have VBZ cord-347946-i6kx3n6m 41 43 occurred occur VBN cord-347946-i6kx3n6m 41 44 ( ( -LRB- cord-347946-i6kx3n6m 41 45 Kinney Kinney NNP cord-347946-i6kx3n6m 41 46 and and CC cord-347946-i6kx3n6m 41 47 Tanaka Tanaka NNP cord-347946-i6kx3n6m 41 48 ) ) -RRB- cord-347946-i6kx3n6m 42 1 Genetic genetic JJ cord-347946-i6kx3n6m 42 2 alleles allele NNS cord-347946-i6kx3n6m 42 3 that that WDT cord-347946-i6kx3n6m 42 4 promote promote VBP cord-347946-i6kx3n6m 42 5 an an DT cord-347946-i6kx3n6m 42 6 inflammatory inflammatory JJ cord-347946-i6kx3n6m 42 7 bias bias NN cord-347946-i6kx3n6m 42 8 have have VBP cord-347946-i6kx3n6m 42 9 undergone undergo VBN cord-347946-i6kx3n6m 42 10 positive positive JJ cord-347946-i6kx3n6m 42 11 selection selection NN cord-347946-i6kx3n6m 42 12 because because IN cord-347946-i6kx3n6m 42 13 in in IN cord-347946-i6kx3n6m 42 14 ancestral ancestral JJ cord-347946-i6kx3n6m 42 15 environments environment NNS cord-347946-i6kx3n6m 42 16 they -PRON- PRP cord-347946-i6kx3n6m 42 17 provided provide VBD cord-347946-i6kx3n6m 42 18 direct direct JJ cord-347946-i6kx3n6m 42 19 pathogen pathogen NN cord-347946-i6kx3n6m 42 20 defense defense NN cord-347946-i6kx3n6m 42 21 and and CC cord-347946-i6kx3n6m 42 22 because because IN cord-347946-i6kx3n6m 42 23 they -PRON- PRP cord-347946-i6kx3n6m 42 24 promoted promote VBD cord-347946-i6kx3n6m 42 25 the the DT cord-347946-i6kx3n6m 42 26 development development NN cord-347946-i6kx3n6m 42 27 of of IN cord-347946-i6kx3n6m 42 28 depressive depressive JJ cord-347946-i6kx3n6m 42 29 symptoms symptom NNS cord-347946-i6kx3n6m 42 30 in in IN cord-347946-i6kx3n6m 42 31 response response NN cord-347946-i6kx3n6m 42 32 to to IN cord-347946-i6kx3n6m 42 33 immune immune JJ cord-347946-i6kx3n6m 42 34 activation activation NN cord-347946-i6kx3n6m 42 35 . . . cord-347946-i6kx3n6m 43 1 Like like IN cord-347946-i6kx3n6m 43 2 sickness sickness NN cord-347946-i6kx3n6m 43 3 behavior behavior NN cord-347946-i6kx3n6m 43 4 , , , cord-347946-i6kx3n6m 43 5 depression depression NN cord-347946-i6kx3n6m 43 6 in in IN cord-347946-i6kx3n6m 43 7 response response NN cord-347946-i6kx3n6m 43 8 to to IN cord-347946-i6kx3n6m 43 9 immune immune JJ cord-347946-i6kx3n6m 43 10 activation activation NN cord-347946-i6kx3n6m 43 11 aided aid VBN cord-347946-i6kx3n6m 43 12 in in IN cord-347946-i6kx3n6m 43 13 host host NN cord-347946-i6kx3n6m 43 14 defense defense NN cord-347946-i6kx3n6m 43 15 both both CC cord-347946-i6kx3n6m 43 16 directly directly RB cord-347946-i6kx3n6m 43 17 ( ( -LRB- cord-347946-i6kx3n6m 43 18 ie ie FW cord-347946-i6kx3n6m 43 19 , , , cord-347946-i6kx3n6m 43 20 raised raise VBN cord-347946-i6kx3n6m 43 21 body body NN cord-347946-i6kx3n6m 43 22 temperature temperature NN cord-347946-i6kx3n6m 43 23 and and CC cord-347946-i6kx3n6m 43 24 energy energy NN cord-347946-i6kx3n6m 43 25 conservation conservation NN cord-347946-i6kx3n6m 43 26 behaviors behavior NNS cord-347946-i6kx3n6m 43 27 ) ) -RRB- cord-347946-i6kx3n6m 43 28 and and CC cord-347946-i6kx3n6m 43 29 indirectly indirectly RB cord-347946-i6kx3n6m 43 30 ( ( -LRB- cord-347946-i6kx3n6m 43 31 social social JJ cord-347946-i6kx3n6m 43 32 avoidance avoidance NN cord-347946-i6kx3n6m 43 33 , , , cord-347946-i6kx3n6m 43 34 energy energy NN cord-347946-i6kx3n6m 43 35 conservation conservation NN cord-347946-i6kx3n6m 43 36 , , , cord-347946-i6kx3n6m 43 37 and and CC cord-347946-i6kx3n6m 43 38 hypervigilance hypervigilance NN cord-347946-i6kx3n6m 43 39 ; ; : cord-347946-i6kx3n6m 43 40 Raison Raison NNP cord-347946-i6kx3n6m 43 41 and and CC cord-347946-i6kx3n6m 43 42 Miller Miller NNP cord-347946-i6kx3n6m 43 43 , , , cord-347946-i6kx3n6m 44 1 pathogen- pathogen- NNP cord-347946-i6kx3n6m 44 2 host host NNP cord-347946-i6kx3n6m 44 3 defense defense NN cord-347946-i6kx3n6m 44 4 theory theory NN cord-347946-i6kx3n6m 44 5 of of IN cord-347946-i6kx3n6m 44 6 depression depression NN cord-347946-i6kx3n6m 44 7 [ [ -LRB- cord-347946-i6kx3n6m 44 8 PATHOS pathos NN cord-347946-i6kx3n6m 44 9 - - HYPH cord-347946-i6kx3n6m 44 10 D D NNP cord-347946-i6kx3n6m 44 11 ] ] -RRB- cord-347946-i6kx3n6m 44 12 ) ) -RRB- cord-347946-i6kx3n6m 45 1 Adaptive adaptive JJ cord-347946-i6kx3n6m 45 2 explanations explanation NNS cord-347946-i6kx3n6m 45 3 for for IN cord-347946-i6kx3n6m 45 4 associations association NNS cord-347946-i6kx3n6m 45 5 between between IN cord-347946-i6kx3n6m 45 6 MDD MDD NNP cord-347946-i6kx3n6m 45 7 and and CC cord-347946-i6kx3n6m 45 8 altered alter VBN cord-347946-i6kx3n6m 45 9 immune immune JJ cord-347946-i6kx3n6m 45 10 functioning functioning NN cord-347946-i6kx3n6m 45 11 are be VBP cord-347946-i6kx3n6m 45 12 not not RB cord-347946-i6kx3n6m 45 13 considered consider VBN cord-347946-i6kx3n6m 45 14 ( ( -LRB- cord-347946-i6kx3n6m 45 15 frequent frequent JJ cord-347946-i6kx3n6m 45 16 unexamined unexamined JJ cord-347946-i6kx3n6m 45 17 assumption assumption NN cord-347946-i6kx3n6m 45 18 of of IN cord-347946-i6kx3n6m 45 19 researchers researcher NNS cord-347946-i6kx3n6m 45 20 working work VBG cord-347946-i6kx3n6m 45 21 on on IN cord-347946-i6kx3n6m 45 22 proximal proximal JJ cord-347946-i6kx3n6m 45 23 mechanisms mechanism NNS cord-347946-i6kx3n6m 45 24 ) ) -RRB- cord-347946-i6kx3n6m 46 1 Toll toll NN cord-347946-i6kx3n6m 46 2 - - HYPH cord-347946-i6kx3n6m 46 3 like like JJ cord-347946-i6kx3n6m 46 4 receptor receptor NN cord-347946-i6kx3n6m 46 5 ( ( -LRB- cord-347946-i6kx3n6m 46 6 TLR TLR NNP cord-347946-i6kx3n6m 46 7 ) ) -RRB- cord-347946-i6kx3n6m 46 8 mRNA mrna NN cord-347946-i6kx3n6m 46 9 and and CC cord-347946-i6kx3n6m 46 10 protein protein NN cord-347946-i6kx3n6m 46 11 have have VBP cord-347946-i6kx3n6m 46 12 been be VBN cord-347946-i6kx3n6m 46 13 reported report VBN cord-347946-i6kx3n6m 46 14 to to TO cord-347946-i6kx3n6m 46 15 be be VB cord-347946-i6kx3n6m 46 16 elevated elevate VBN cord-347946-i6kx3n6m 46 17 in in IN cord-347946-i6kx3n6m 46 18 both both CC cord-347946-i6kx3n6m 46 19 the the DT cord-347946-i6kx3n6m 46 20 periphery periphery NN cord-347946-i6kx3n6m 46 21 and and CC cord-347946-i6kx3n6m 46 22 CNS CNS NNP cord-347946-i6kx3n6m 46 23 of of IN cord-347946-i6kx3n6m 46 24 individuals individual NNS cord-347946-i6kx3n6m 46 25 with with IN cord-347946-i6kx3n6m 46 26 MDD MDD NNP cord-347946-i6kx3n6m 46 27 ( ( -LRB- cord-347946-i6kx3n6m 46 28 Hung Hung NNP cord-347946-i6kx3n6m 46 29 et et NNP cord-347946-i6kx3n6m 46 30 al al NNP cord-347946-i6kx3n6m 46 31 , , , cord-347946-i6kx3n6m 46 32 2014 2014 CD cord-347946-i6kx3n6m 47 1 ( ( -LRB- cord-347946-i6kx3n6m 47 2 Hung Hung NNP cord-347946-i6kx3n6m 47 3 et et FW cord-347946-i6kx3n6m 47 4 al al NNP cord-347946-i6kx3n6m 47 5 , , , cord-347946-i6kx3n6m 47 6 , , , cord-347946-i6kx3n6m 47 7 2015 2015 CD cord-347946-i6kx3n6m 47 8 Keri Keri NNP cord-347946-i6kx3n6m 47 9 et et NNP cord-347946-i6kx3n6m 47 10 al al NNP cord-347946-i6kx3n6m 47 11 , , , cord-347946-i6kx3n6m 47 12 2014 2014 CD cord-347946-i6kx3n6m 47 13 ; ; : cord-347946-i6kx3n6m 47 14 van van NNP cord-347946-i6kx3n6m 47 15 Dooren Dooren NNP cord-347946-i6kx3n6m 47 16 et et NNP cord-347946-i6kx3n6m 47 17 al al NNP cord-347946-i6kx3n6m 47 18 , , , cord-347946-i6kx3n6m 47 19 2016 2016 CD cord-347946-i6kx3n6m 47 20 ) ) -RRB- cord-347946-i6kx3n6m 47 21 , , , cord-347946-i6kx3n6m 47 22 with with IN cord-347946-i6kx3n6m 47 23 some some DT cord-347946-i6kx3n6m 47 24 evidence evidence NN cord-347946-i6kx3n6m 47 25 suggesting suggest VBG cord-347946-i6kx3n6m 47 26 that that IN cord-347946-i6kx3n6m 47 27 successful successful JJ cord-347946-i6kx3n6m 47 28 pharmaco pharmaco NNS cord-347946-i6kx3n6m 47 29 - - HYPH cord-347946-i6kx3n6m 47 30 or or CC cord-347946-i6kx3n6m 47 31 psychotherapy psychotherapy NN cord-347946-i6kx3n6m 47 32 reduces reduce VBZ cord-347946-i6kx3n6m 47 33 peripheral peripheral JJ cord-347946-i6kx3n6m 47 34 TLR TLR NNP cord-347946-i6kx3n6m 47 35 activity activity NN cord-347946-i6kx3n6m 48 1 ( ( -LRB- cord-347946-i6kx3n6m 48 2 Keri Keri NNP cord-347946-i6kx3n6m 48 3 et et NNP cord-347946-i6kx3n6m 48 4 al al NNP cord-347946-i6kx3n6m 48 5 , , , cord-347946-i6kx3n6m 48 6 2014 2014 CD cord-347946-i6kx3n6m 48 7 ; ; : cord-347946-i6kx3n6m 48 8 Hung Hung NNP cord-347946-i6kx3n6m 48 9 et et NNP cord-347946-i6kx3n6m 48 10 al al NNP cord-347946-i6kx3n6m 48 11 , , , cord-347946-i6kx3n6m 48 12 2015 2015 CD cord-347946-i6kx3n6m 48 13 ) ) -RRB- cord-347946-i6kx3n6m 48 14 . . . cord-347946-i6kx3n6m 49 1 Of of IN cord-347946-i6kx3n6m 49 2 these these DT cord-347946-i6kx3n6m 49 3 various various JJ cord-347946-i6kx3n6m 49 4 findings finding NNS cord-347946-i6kx3n6m 49 5 , , , cord-347946-i6kx3n6m 49 6 meta meta NNP cord-347946-i6kx3n6m 49 7 - - HYPH cord-347946-i6kx3n6m 49 8 analyses analysis NNS cord-347946-i6kx3n6m 49 9 suggest suggest VBP cord-347946-i6kx3n6m 49 10 that that IN cord-347946-i6kx3n6m 49 11 the the DT cord-347946-i6kx3n6m 49 12 best well RBS cord-347946-i6kx3n6m 49 13 replicated replicate VBN cord-347946-i6kx3n6m 49 14 associations association NNS cord-347946-i6kx3n6m 49 15 between between IN cord-347946-i6kx3n6m 49 16 depression depression NN cord-347946-i6kx3n6m 49 17 and and CC cord-347946-i6kx3n6m 49 18 inflammatory inflammatory JJ cord-347946-i6kx3n6m 49 19 biomarkers biomarker NNS cord-347946-i6kx3n6m 49 20 are be VBP cord-347946-i6kx3n6m 49 21 increases increase NNS cord-347946-i6kx3n6m 49 22 in in IN cord-347946-i6kx3n6m 49 23 circulating circulate VBG cord-347946-i6kx3n6m 49 24 levels level NNS cord-347946-i6kx3n6m 49 25 of of IN cord-347946-i6kx3n6m 49 26 c c NN cord-347946-i6kx3n6m 49 27 - - HYPH cord-347946-i6kx3n6m 49 28 reactive reactive JJ cord-347946-i6kx3n6m 49 29 protein protein NN cord-347946-i6kx3n6m 49 30 ( ( -LRB- cord-347946-i6kx3n6m 49 31 CRP CRP NNP cord-347946-i6kx3n6m 49 32 ) ) -RRB- cord-347946-i6kx3n6m 49 33 and and CC cord-347946-i6kx3n6m 49 34 IL-6 IL-6 NNP cord-347946-i6kx3n6m 49 35 ( ( -LRB- cord-347946-i6kx3n6m 49 36 Howren Howren NNP cord-347946-i6kx3n6m 49 37 et et NNP cord-347946-i6kx3n6m 49 38 al al NNP cord-347946-i6kx3n6m 49 39 , , , cord-347946-i6kx3n6m 49 40 2009 2009 CD cord-347946-i6kx3n6m 49 41 ; ; : cord-347946-i6kx3n6m 49 42 Dowlati Dowlati NNP cord-347946-i6kx3n6m 49 43 et et FW cord-347946-i6kx3n6m 49 44 al al NNP cord-347946-i6kx3n6m 49 45 , , , cord-347946-i6kx3n6m 49 46 2010 2010 CD cord-347946-i6kx3n6m 49 47 ; ; : cord-347946-i6kx3n6m 49 48 Liu Liu NNP cord-347946-i6kx3n6m 49 49 et et NNP cord-347946-i6kx3n6m 49 50 al al NNP cord-347946-i6kx3n6m 49 51 , , , cord-347946-i6kx3n6m 49 52 2012b 2012b CD cord-347946-i6kx3n6m 49 53 ; ; : cord-347946-i6kx3n6m 49 54 Valkanova Valkanova NNP cord-347946-i6kx3n6m 49 55 et et NNP cord-347946-i6kx3n6m 49 56 al al NNP cord-347946-i6kx3n6m 49 57 , , , cord-347946-i6kx3n6m 49 58 2013 2013 CD cord-347946-i6kx3n6m 49 59 ; ; : cord-347946-i6kx3n6m 50 1 Black Black NNP cord-347946-i6kx3n6m 50 2 and and CC cord-347946-i6kx3n6m 50 3 Miller Miller NNP cord-347946-i6kx3n6m 50 4 , , , cord-347946-i6kx3n6m 50 5 2015 2015 CD cord-347946-i6kx3n6m 50 6 ; ; : cord-347946-i6kx3n6m 50 7 Haapakoski Haapakoski NNP cord-347946-i6kx3n6m 50 8 et et NNP cord-347946-i6kx3n6m 50 9 al al NNP cord-347946-i6kx3n6m 50 10 , , , cord-347946-i6kx3n6m 50 11 2015 2015 CD cord-347946-i6kx3n6m 50 12 ) ) -RRB- cord-347946-i6kx3n6m 50 13 . . . cord-347946-i6kx3n6m 51 1 Taken take VBN cord-347946-i6kx3n6m 51 2 as as IN cord-347946-i6kx3n6m 51 3 a a DT cord-347946-i6kx3n6m 51 4 whole whole NN cord-347946-i6kx3n6m 51 5 , , , cord-347946-i6kx3n6m 51 6 the the DT cord-347946-i6kx3n6m 51 7 meta meta JJ cord-347946-i6kx3n6m 51 8 - - HYPH cord-347946-i6kx3n6m 51 9 analytic analytic JJ cord-347946-i6kx3n6m 51 10 literature literature NN cord-347946-i6kx3n6m 51 11 also also RB cord-347946-i6kx3n6m 51 12 supports support VBZ cord-347946-i6kx3n6m 51 13 an an DT cord-347946-i6kx3n6m 51 14 association association NN cord-347946-i6kx3n6m 51 15 with with IN cord-347946-i6kx3n6m 51 16 circulating circulate VBG cord-347946-i6kx3n6m 51 17 levels level NNS cord-347946-i6kx3n6m 51 18 of of IN cord-347946-i6kx3n6m 51 19 tumor tumor NN cord-347946-i6kx3n6m 51 20 necrosis necrosis NN cord-347946-i6kx3n6m 51 21 factor factor NN cord-347946-i6kx3n6m 51 22 ( ( -LRB- cord-347946-i6kx3n6m 51 23 TNF TNF NNP cord-347946-i6kx3n6m 51 24 ) ) -RRB- cord-347946-i6kx3n6m 51 25 and and CC cord-347946-i6kx3n6m 51 26 IL-1-β il-1-β IN cord-347946-i6kx3n6m 51 27 , , , cord-347946-i6kx3n6m 51 28 although although IN cord-347946-i6kx3n6m 51 29 with with IN cord-347946-i6kx3n6m 51 30 more more JJR cord-347946-i6kx3n6m 51 31 variability variability NN cord-347946-i6kx3n6m 51 32 . . . cord-347946-i6kx3n6m 52 1 Because because IN cord-347946-i6kx3n6m 52 2 IL-1-β il-1-β PRP cord-347946-i6kx3n6m 52 3 features feature VBZ cord-347946-i6kx3n6m 52 4 so so RB cord-347946-i6kx3n6m 52 5 prominently prominently RB cord-347946-i6kx3n6m 52 6 in in IN cord-347946-i6kx3n6m 52 7 both both CC cord-347946-i6kx3n6m 52 8 the the DT cord-347946-i6kx3n6m 52 9 inflammatory inflammatory JJ cord-347946-i6kx3n6m 52 10 response response NN cord-347946-i6kx3n6m 52 11 and and CC cord-347946-i6kx3n6m 52 12 in in IN cord-347946-i6kx3n6m 52 13 animal animal NN cord-347946-i6kx3n6m 52 14 studies study NNS cord-347946-i6kx3n6m 52 15 of of IN cord-347946-i6kx3n6m 52 16 stress stress NN cord-347946-i6kx3n6m 52 17 , , , cord-347946-i6kx3n6m 52 18 and and CC cord-347946-i6kx3n6m 52 19 depression depression NN cord-347946-i6kx3n6m 52 20 - - HYPH cord-347946-i6kx3n6m 52 21 like like JJ cord-347946-i6kx3n6m 52 22 behavior behavior NN cord-347946-i6kx3n6m 52 23 , , , cord-347946-i6kx3n6m 52 24 it -PRON- PRP cord-347946-i6kx3n6m 52 25 is be VBZ cord-347946-i6kx3n6m 52 26 curious curious JJ cord-347946-i6kx3n6m 52 27 that that IN cord-347946-i6kx3n6m 52 28 meta meta NNP cord-347946-i6kx3n6m 52 29 - - HYPH cord-347946-i6kx3n6m 52 30 analyses analysis NNS cord-347946-i6kx3n6m 52 31 split split VBD cord-347946-i6kx3n6m 52 32 on on IN cord-347946-i6kx3n6m 52 33 whether whether IN cord-347946-i6kx3n6m 52 34 it -PRON- PRP cord-347946-i6kx3n6m 52 35 is be VBZ cord-347946-i6kx3n6m 52 36 elevated elevate VBN cord-347946-i6kx3n6m 52 37 in in IN cord-347946-i6kx3n6m 52 38 the the DT cord-347946-i6kx3n6m 52 39 blood blood NN cord-347946-i6kx3n6m 52 40 of of IN cord-347946-i6kx3n6m 52 41 patients patient NNS cord-347946-i6kx3n6m 52 42 with with IN cord-347946-i6kx3n6m 52 43 MDD MDD NNP cord-347946-i6kx3n6m 52 44 ( ( -LRB- cord-347946-i6kx3n6m 52 45 Dowlati Dowlati NNP cord-347946-i6kx3n6m 52 46 et et FW cord-347946-i6kx3n6m 52 47 al al NNP cord-347946-i6kx3n6m 52 48 , , , cord-347946-i6kx3n6m 52 49 2010 2010 CD cord-347946-i6kx3n6m 52 50 ; ; : cord-347946-i6kx3n6m 52 51 Black Black NNP cord-347946-i6kx3n6m 52 52 and and CC cord-347946-i6kx3n6m 52 53 Miller Miller NNP cord-347946-i6kx3n6m 52 54 , , , cord-347946-i6kx3n6m 52 55 2015 2015 CD cord-347946-i6kx3n6m 52 56 ) ) -RRB- cord-347946-i6kx3n6m 52 57 . . . cord-347946-i6kx3n6m 53 1 One one CD cord-347946-i6kx3n6m 53 2 possible possible JJ cord-347946-i6kx3n6m 53 3 explanation explanation NN cord-347946-i6kx3n6m 53 4 that that WDT cord-347946-i6kx3n6m 53 5 would would MD cord-347946-i6kx3n6m 53 6 be be VB cord-347946-i6kx3n6m 53 7 consistent consistent JJ cord-347946-i6kx3n6m 53 8 with with IN cord-347946-i6kx3n6m 53 9 the the DT cord-347946-i6kx3n6m 53 10 animal animal NN cord-347946-i6kx3n6m 53 11 literature literature NN cord-347946-i6kx3n6m 53 12 is be VBZ cord-347946-i6kx3n6m 53 13 that that IN cord-347946-i6kx3n6m 53 14 IL-1-β il-1-β PRP cord-347946-i6kx3n6m 53 15 has have VBZ cord-347946-i6kx3n6m 53 16 a a DT cord-347946-i6kx3n6m 53 17 larger large JJR cord-347946-i6kx3n6m 53 18 role role NN cord-347946-i6kx3n6m 53 19 in in IN cord-347946-i6kx3n6m 53 20 the the DT cord-347946-i6kx3n6m 53 21 CNS CNS NNP cord-347946-i6kx3n6m 53 22 than than IN cord-347946-i6kx3n6m 53 23 the the DT cord-347946-i6kx3n6m 53 24 periphery periphery NN cord-347946-i6kx3n6m 53 25 in in IN cord-347946-i6kx3n6m 53 26 terms term NNS cord-347946-i6kx3n6m 53 27 of of IN cord-347946-i6kx3n6m 53 28 depressogenesis depressogenesis NN cord-347946-i6kx3n6m 53 29 . . . cord-347946-i6kx3n6m 54 1 Consistent consistent JJ cord-347946-i6kx3n6m 54 2 with with IN cord-347946-i6kx3n6m 54 3 this this DT cord-347946-i6kx3n6m 54 4 , , , cord-347946-i6kx3n6m 54 5 some some DT cord-347946-i6kx3n6m 54 6 evidence evidence NN cord-347946-i6kx3n6m 54 7 suggests suggest VBZ cord-347946-i6kx3n6m 54 8 that that IN cord-347946-i6kx3n6m 54 9 IL-1-β il-1-β PRP cord-347946-i6kx3n6m 54 10 is be VBZ cord-347946-i6kx3n6m 54 11 elevated elevate VBN cord-347946-i6kx3n6m 54 12 in in IN cord-347946-i6kx3n6m 54 13 the the DT cord-347946-i6kx3n6m 54 14 CSF CSF NNP cord-347946-i6kx3n6m 54 15 of of IN cord-347946-i6kx3n6m 54 16 depressed depressed JJ cord-347946-i6kx3n6m 54 17 individuals individual NNS cord-347946-i6kx3n6m 54 18 ( ( -LRB- cord-347946-i6kx3n6m 54 19 Levine Levine NNP cord-347946-i6kx3n6m 54 20 et et NNP cord-347946-i6kx3n6m 54 21 al al NNP cord-347946-i6kx3n6m 54 22 , , , cord-347946-i6kx3n6m 54 23 1999 1999 CD cord-347946-i6kx3n6m 54 24 ) ) -RRB- cord-347946-i6kx3n6m 54 25 . . . cord-347946-i6kx3n6m 55 1 Alternately alternately RB cord-347946-i6kx3n6m 55 2 , , , cord-347946-i6kx3n6m 55 3 evidence evidence NN cord-347946-i6kx3n6m 55 4 linking link VBG cord-347946-i6kx3n6m 55 5 IL-1-β il-1-β IN cord-347946-i6kx3n6m 55 6 to to IN cord-347946-i6kx3n6m 55 7 MDD MDD NNP cord-347946-i6kx3n6m 55 8 may may MD cord-347946-i6kx3n6m 55 9 not not RB cord-347946-i6kx3n6m 55 10 be be VB cord-347946-i6kx3n6m 55 11 robust robust JJ cord-347946-i6kx3n6m 55 12 because because IN cord-347946-i6kx3n6m 55 13 of of IN cord-347946-i6kx3n6m 55 14 limitations limitation NNS cord-347946-i6kx3n6m 55 15 in in IN cord-347946-i6kx3n6m 55 16 assay assay NN cord-347946-i6kx3n6m 55 17 methods method NNS cord-347946-i6kx3n6m 55 18 in in IN cord-347946-i6kx3n6m 55 19 detecting detect VBG cord-347946-i6kx3n6m 55 20 levels level NNS cord-347946-i6kx3n6m 55 21 of of IN cord-347946-i6kx3n6m 55 22 IL-1 IL-1 NNP cord-347946-i6kx3n6m 55 23 in in IN cord-347946-i6kx3n6m 55 24 human human JJ cord-347946-i6kx3n6m 55 25 studies study NNS cord-347946-i6kx3n6m 55 26 . . . cord-347946-i6kx3n6m 56 1 Although although IN cord-347946-i6kx3n6m 56 2 increases increase NNS cord-347946-i6kx3n6m 56 3 in in IN cord-347946-i6kx3n6m 56 4 inflammatory inflammatory JJ cord-347946-i6kx3n6m 56 5 biomarkers biomarker NNS cord-347946-i6kx3n6m 56 6 in in IN cord-347946-i6kx3n6m 56 7 depressed depressed JJ cord-347946-i6kx3n6m 56 8 patients patient NNS cord-347946-i6kx3n6m 56 9 compared compare VBN cord-347946-i6kx3n6m 56 10 with with IN cord-347946-i6kx3n6m 56 11 controls control NNS cord-347946-i6kx3n6m 56 12 are be VBP cord-347946-i6kx3n6m 56 13 modest modest JJ cord-347946-i6kx3n6m 56 14 when when WRB cord-347946-i6kx3n6m 56 15 compared compare VBN cord-347946-i6kx3n6m 56 16 with with IN cord-347946-i6kx3n6m 56 17 acute acute JJ cord-347946-i6kx3n6m 56 18 infections infection NNS cord-347946-i6kx3n6m 56 19 or or CC cord-347946-i6kx3n6m 56 20 autoimmune autoimmune JJ cord-347946-i6kx3n6m 56 21 conditions condition NNS cord-347946-i6kx3n6m 56 22 , , , cord-347946-i6kx3n6m 56 23 recent recent JJ cord-347946-i6kx3n6m 56 24 animal animal NN cord-347946-i6kx3n6m 56 25 data datum NNS cord-347946-i6kx3n6m 56 26 demonstrate demonstrate VBP cord-347946-i6kx3n6m 56 27 that that IN cord-347946-i6kx3n6m 56 28 these these DT cord-347946-i6kx3n6m 56 29 types type NNS cord-347946-i6kx3n6m 56 30 of of IN cord-347946-i6kx3n6m 56 31 low low JJ cord-347946-i6kx3n6m 56 32 - - HYPH cord-347946-i6kx3n6m 56 33 level level NN cord-347946-i6kx3n6m 56 34 inflammatory inflammatory JJ cord-347946-i6kx3n6m 56 35 stimulation stimulation NN cord-347946-i6kx3n6m 56 36 are be VBP cord-347946-i6kx3n6m 56 37 sufficient sufficient JJ cord-347946-i6kx3n6m 56 38 to to TO cord-347946-i6kx3n6m 56 39 induce induce VB cord-347946-i6kx3n6m 56 40 depressive depressive JJ cord-347946-i6kx3n6m 56 41 - - HYPH cord-347946-i6kx3n6m 56 42 like like JJ cord-347946-i6kx3n6m 56 43 behavior behavior NN cord-347946-i6kx3n6m 56 44 and and CC cord-347946-i6kx3n6m 56 45 associated associated JJ cord-347946-i6kx3n6m 56 46 brain brain NN cord-347946-i6kx3n6m 56 47 changes change NNS cord-347946-i6kx3n6m 56 48 when when WRB cord-347946-i6kx3n6m 56 49 such such JJ cord-347946-i6kx3n6m 56 50 stimulation stimulation NN cord-347946-i6kx3n6m 56 51 is be VBZ cord-347946-i6kx3n6m 56 52 chronic chronic JJ cord-347946-i6kx3n6m 56 53 ( ( -LRB- cord-347946-i6kx3n6m 56 54 Tarr Tarr NNP cord-347946-i6kx3n6m 56 55 et et FW cord-347946-i6kx3n6m 56 56 al al NNP cord-347946-i6kx3n6m 56 57 , , , cord-347946-i6kx3n6m 56 58 2012a 2012a CD cord-347946-i6kx3n6m 56 59 ) ) -RRB- cord-347946-i6kx3n6m 56 60 , , , cord-347946-i6kx3n6m 56 61 such such JJ cord-347946-i6kx3n6m 56 62 as as IN cord-347946-i6kx3n6m 56 63 appears appear VBZ cord-347946-i6kx3n6m 56 64 to to TO cord-347946-i6kx3n6m 56 65 be be VB cord-347946-i6kx3n6m 56 66 the the DT cord-347946-i6kx3n6m 56 67 case case NN cord-347946-i6kx3n6m 56 68 in in IN cord-347946-i6kx3n6m 56 69 many many JJ cord-347946-i6kx3n6m 56 70 individuals individual NNS cord-347946-i6kx3n6m 56 71 with with IN cord-347946-i6kx3n6m 56 72 MDD MDD NNP cord-347946-i6kx3n6m 56 73 . . . cord-347946-i6kx3n6m 57 1 Figure figure NN cord-347946-i6kx3n6m 57 2 1 1 CD cord-347946-i6kx3n6m 57 3 . . . cord-347946-i6kx3n6m 58 1 Man man NN cord-347946-i6kx3n6m 58 2 meets meet VBZ cord-347946-i6kx3n6m 58 3 microbes microbe NNS cord-347946-i6kx3n6m 58 4 . . . cord-347946-i6kx3n6m 59 1 In in IN cord-347946-i6kx3n6m 59 2 ancestral ancestral JJ cord-347946-i6kx3n6m 59 3 environments environment NNS cord-347946-i6kx3n6m 59 4 , , , cord-347946-i6kx3n6m 59 5 heavy heavy JJ cord-347946-i6kx3n6m 59 6 pathogen pathogen NN cord-347946-i6kx3n6m 59 7 loads load NNS cord-347946-i6kx3n6m 59 8 applied apply VBD cord-347946-i6kx3n6m 59 9 significant significant JJ cord-347946-i6kx3n6m 59 10 evolutionary evolutionary JJ cord-347946-i6kx3n6m 59 11 pressure pressure NN cord-347946-i6kx3n6m 59 12 on on IN cord-347946-i6kx3n6m 59 13 human human JJ cord-347946-i6kx3n6m 59 14 survival survival NN cord-347946-i6kx3n6m 59 15 that that WDT cord-347946-i6kx3n6m 59 16 ultimately ultimately RB cord-347946-i6kx3n6m 59 17 entailed entail VBD cord-347946-i6kx3n6m 59 18 a a DT cord-347946-i6kx3n6m 59 19 host host NN cord-347946-i6kx3n6m 59 20 of of IN cord-347946-i6kx3n6m 59 21 adaptations adaptation NNS cord-347946-i6kx3n6m 59 22 that that WDT cord-347946-i6kx3n6m 59 23 , , , cord-347946-i6kx3n6m 59 24 according accord VBG cord-347946-i6kx3n6m 59 25 to to IN cord-347946-i6kx3n6m 59 26 the the DT cord-347946-i6kx3n6m 59 27 pathogen pathogen NN cord-347946-i6kx3n6m 59 28 - - HYPH cord-347946-i6kx3n6m 59 29 host host NN cord-347946-i6kx3n6m 59 30 theory theory NN cord-347946-i6kx3n6m 59 31 of of IN cord-347946-i6kx3n6m 59 32 depression depression NN cord-347946-i6kx3n6m 59 33 , , , cord-347946-i6kx3n6m 59 34 shaped shape VBN cord-347946-i6kx3n6m 59 35 interactions interaction NNS cord-347946-i6kx3n6m 59 36 between between IN cord-347946-i6kx3n6m 59 37 the the DT cord-347946-i6kx3n6m 59 38 immune immune JJ cord-347946-i6kx3n6m 59 39 system system NN cord-347946-i6kx3n6m 59 40 ( ( -LRB- cord-347946-i6kx3n6m 59 41 inflammation inflammation NN cord-347946-i6kx3n6m 59 42 in in IN cord-347946-i6kx3n6m 59 43 particular particular JJ cord-347946-i6kx3n6m 59 44 ) ) -RRB- cord-347946-i6kx3n6m 59 45 and and CC cord-347946-i6kx3n6m 59 46 the the DT cord-347946-i6kx3n6m 59 47 brain brain NN cord-347946-i6kx3n6m 59 48 , , , cord-347946-i6kx3n6m 59 49 leading lead VBG cord-347946-i6kx3n6m 59 50 to to IN cord-347946-i6kx3n6m 59 51 a a DT cord-347946-i6kx3n6m 59 52 unique unique JJ cord-347946-i6kx3n6m 59 53 set set NN cord-347946-i6kx3n6m 59 54 of of IN cord-347946-i6kx3n6m 59 55 behaviors behavior NNS cord-347946-i6kx3n6m 59 56 . . . cord-347946-i6kx3n6m 60 1 These these DT cord-347946-i6kx3n6m 60 2 behaviors behavior NNS cord-347946-i6kx3n6m 60 3 , , , cord-347946-i6kx3n6m 60 4 including include VBG cord-347946-i6kx3n6m 60 5 anhedonia anhedonia NN cord-347946-i6kx3n6m 60 6 , , , cord-347946-i6kx3n6m 60 7 fatigue fatigue NN cord-347946-i6kx3n6m 60 8 , , , cord-347946-i6kx3n6m 60 9 and and CC cord-347946-i6kx3n6m 60 10 psychomotor psychomotor NN cord-347946-i6kx3n6m 60 11 slowing slow VBG cord-347946-i6kx3n6m 60 12 as as RB cord-347946-i6kx3n6m 60 13 well well RB cord-347946-i6kx3n6m 60 14 as as IN cord-347946-i6kx3n6m 60 15 anxiety anxiety NN cord-347946-i6kx3n6m 60 16 , , , cord-347946-i6kx3n6m 60 17 arousal arousal NN cord-347946-i6kx3n6m 60 18 and and CC cord-347946-i6kx3n6m 60 19 alarm alarm NN cord-347946-i6kx3n6m 60 20 supported support VBD cord-347946-i6kx3n6m 60 21 energy energy NN cord-347946-i6kx3n6m 60 22 conservation conservation NN cord-347946-i6kx3n6m 60 23 for for IN cord-347946-i6kx3n6m 60 24 fighting fight VBG cord-347946-i6kx3n6m 60 25 infection infection NN cord-347946-i6kx3n6m 60 26 and and CC cord-347946-i6kx3n6m 60 27 wound wound VB cord-347946-i6kx3n6m 60 28 healing healing NN cord-347946-i6kx3n6m 60 29 and and CC cord-347946-i6kx3n6m 60 30 hypervigilance hypervigilance NN cord-347946-i6kx3n6m 60 31 to to TO cord-347946-i6kx3n6m 60 32 prevent prevent VB cord-347946-i6kx3n6m 60 33 future future JJ cord-347946-i6kx3n6m 60 34 attack attack NN cord-347946-i6kx3n6m 60 35 . . . cord-347946-i6kx3n6m 61 1 In in IN cord-347946-i6kx3n6m 61 2 addition addition NN cord-347946-i6kx3n6m 61 3 , , , cord-347946-i6kx3n6m 61 4 these these DT cord-347946-i6kx3n6m 61 5 evolutionary evolutionary JJ cord-347946-i6kx3n6m 61 6 forces force NNS cord-347946-i6kx3n6m 61 7 instantiated instantiate VBD cord-347946-i6kx3n6m 61 8 a a DT cord-347946-i6kx3n6m 61 9 coupling coupling NN cord-347946-i6kx3n6m 61 10 of of IN cord-347946-i6kx3n6m 61 11 these these DT cord-347946-i6kx3n6m 61 12 behavioral behavioral JJ cord-347946-i6kx3n6m 61 13 responses response NNS cord-347946-i6kx3n6m 61 14 with with IN cord-347946-i6kx3n6m 61 15 the the DT cord-347946-i6kx3n6m 61 16 acute acute JJ cord-347946-i6kx3n6m 61 17 phase phase NN cord-347946-i6kx3n6m 61 18 response response NN cord-347946-i6kx3n6m 61 19 including include VBG cord-347946-i6kx3n6m 61 20 not not RB cord-347946-i6kx3n6m 61 21 only only RB cord-347946-i6kx3n6m 61 22 increases increase NNS cord-347946-i6kx3n6m 61 23 in in IN cord-347946-i6kx3n6m 61 24 acute acute JJ cord-347946-i6kx3n6m 61 25 phase phase NN cord-347946-i6kx3n6m 61 26 reactants reactant NNS cord-347946-i6kx3n6m 61 27 such such JJ cord-347946-i6kx3n6m 61 28 as as IN cord-347946-i6kx3n6m 61 29 c c NN cord-347946-i6kx3n6m 61 30 - - HYPH cord-347946-i6kx3n6m 61 31 reactive reactive JJ cord-347946-i6kx3n6m 61 32 protein protein NN cord-347946-i6kx3n6m 61 33 but but CC cord-347946-i6kx3n6m 61 34 also also RB cord-347946-i6kx3n6m 61 35 hypoferremia hypoferremia NNP cord-347946-i6kx3n6m 61 36 and and CC cord-347946-i6kx3n6m 61 37 zinc zinc NN cord-347946-i6kx3n6m 61 38 deficiency deficiency NN cord-347946-i6kx3n6m 61 39 , , , cord-347946-i6kx3n6m 61 40 as as RB cord-347946-i6kx3n6m 61 41 well well RB cord-347946-i6kx3n6m 61 42 as as IN cord-347946-i6kx3n6m 61 43 fever fever NN cord-347946-i6kx3n6m 61 44 , , , cord-347946-i6kx3n6m 61 45 which which WDT cord-347946-i6kx3n6m 61 46 are be VBP cord-347946-i6kx3n6m 61 47 better well RBR cord-347946-i6kx3n6m 61 48 suited suit VBN cord-347946-i6kx3n6m 61 49 for for IN cord-347946-i6kx3n6m 61 50 interactions interaction NNS cord-347946-i6kx3n6m 61 51 with with IN cord-347946-i6kx3n6m 61 52 pathogens pathogen NNS cord-347946-i6kx3n6m 61 53 than than IN cord-347946-i6kx3n6m 61 54 people people NNS cord-347946-i6kx3n6m 61 55 . . . cord-347946-i6kx3n6m 62 1 In in IN cord-347946-i6kx3n6m 62 2 addition addition NN cord-347946-i6kx3n6m 62 3 , , , cord-347946-i6kx3n6m 62 4 evolutionary evolutionary JJ cord-347946-i6kx3n6m 62 5 pressures pressure NNS cord-347946-i6kx3n6m 62 6 from from IN cord-347946-i6kx3n6m 62 7 human human JJ cord-347946-i6kx3n6m 62 8 interactions interaction NNS cord-347946-i6kx3n6m 62 9 with with IN cord-347946-i6kx3n6m 62 10 the the DT cord-347946-i6kx3n6m 62 11 microbial microbial JJ cord-347946-i6kx3n6m 62 12 world world NN cord-347946-i6kx3n6m 62 13 can can MD cord-347946-i6kx3n6m 62 14 explain explain VB cord-347946-i6kx3n6m 62 15 risk risk NN cord-347946-i6kx3n6m 62 16 alleles allele NNS cord-347946-i6kx3n6m 62 17 that that WDT cord-347946-i6kx3n6m 62 18 are be VBP cord-347946-i6kx3n6m 62 19 specific specific JJ cord-347946-i6kx3n6m 62 20 to to IN cord-347946-i6kx3n6m 62 21 the the DT cord-347946-i6kx3n6m 62 22 pathogens pathogen NNS cord-347946-i6kx3n6m 62 23 to to TO cord-347946-i6kx3n6m 62 24 which which WDT cord-347946-i6kx3n6m 62 25 given give VBN cord-347946-i6kx3n6m 62 26 populations population NNS cord-347946-i6kx3n6m 62 27 were be VBD cord-347946-i6kx3n6m 62 28 exposed expose VBN cord-347946-i6kx3n6m 62 29 as as RB cord-347946-i6kx3n6m 62 30 well well RB cord-347946-i6kx3n6m 62 31 as as IN cord-347946-i6kx3n6m 62 32 epidemiologic epidemiologic JJ cord-347946-i6kx3n6m 62 33 features feature NNS cord-347946-i6kx3n6m 62 34 of of IN cord-347946-i6kx3n6m 62 35 depression depression NN cord-347946-i6kx3n6m 62 36 such such JJ cord-347946-i6kx3n6m 62 37 as as IN cord-347946-i6kx3n6m 62 38 female female JJ cord-347946-i6kx3n6m 62 39 sex sex NN cord-347946-i6kx3n6m 62 40 preponderance preponderance NN cord-347946-i6kx3n6m 62 41 , , , cord-347946-i6kx3n6m 62 42 an an DT cord-347946-i6kx3n6m 62 43 early early JJ cord-347946-i6kx3n6m 62 44 age age NN cord-347946-i6kx3n6m 62 45 of of IN cord-347946-i6kx3n6m 62 46 onset onset NN cord-347946-i6kx3n6m 62 47 , , , cord-347946-i6kx3n6m 62 48 and and CC cord-347946-i6kx3n6m 62 49 occurrence occurrence NN cord-347946-i6kx3n6m 62 50 in in IN cord-347946-i6kx3n6m 62 51 the the DT cord-347946-i6kx3n6m 62 52 postpartum postpartum NN cord-347946-i6kx3n6m 62 53 period period NN cord-347946-i6kx3n6m 62 54 that that WDT cord-347946-i6kx3n6m 62 55 supported support VBD cord-347946-i6kx3n6m 62 56 reproductive reproductive JJ cord-347946-i6kx3n6m 62 57 success success NN cord-347946-i6kx3n6m 62 58 . . . cord-347946-i6kx3n6m 63 1 Finally finally RB cord-347946-i6kx3n6m 63 2 , , , cord-347946-i6kx3n6m 63 3 the the DT cord-347946-i6kx3n6m 63 4 pathogen pathogen NN cord-347946-i6kx3n6m 63 5 - - HYPH cord-347946-i6kx3n6m 63 6 host host NN cord-347946-i6kx3n6m 63 7 theory theory NN cord-347946-i6kx3n6m 63 8 of of IN cord-347946-i6kx3n6m 63 9 depression depression NN cord-347946-i6kx3n6m 63 10 is be VBZ cord-347946-i6kx3n6m 63 11 consistent consistent JJ cord-347946-i6kx3n6m 63 12 with with IN cord-347946-i6kx3n6m 63 13 modern modern JJ cord-347946-i6kx3n6m 63 14 risk risk NN cord-347946-i6kx3n6m 63 15 factors factor NNS cord-347946-i6kx3n6m 63 16 for for IN cord-347946-i6kx3n6m 63 17 depressive depressive JJ cord-347946-i6kx3n6m 63 18 symptoms symptom NNS cord-347946-i6kx3n6m 63 19 , , , cord-347946-i6kx3n6m 63 20 including include VBG cord-347946-i6kx3n6m 63 21 obesity obesity NN cord-347946-i6kx3n6m 63 22 , , , cord-347946-i6kx3n6m 63 23 processed process VBN cord-347946-i6kx3n6m 63 24 - - HYPH cord-347946-i6kx3n6m 63 25 food food NN cord-347946-i6kx3n6m 63 26 - - HYPH cord-347946-i6kx3n6m 63 27 based base VBN cord-347946-i6kx3n6m 63 28 diets diet NNS cord-347946-i6kx3n6m 63 29 , , , cord-347946-i6kx3n6m 63 30 sedentary sedentary JJ cord-347946-i6kx3n6m 63 31 lifestyle lifestyle NN cord-347946-i6kx3n6m 63 32 , , , cord-347946-i6kx3n6m 63 33 and and CC cord-347946-i6kx3n6m 63 34 sleep sleep NN cord-347946-i6kx3n6m 63 35 deprivation deprivation NN cord-347946-i6kx3n6m 63 36 , , , cord-347946-i6kx3n6m 63 37 all all DT cord-347946-i6kx3n6m 63 38 of of IN cord-347946-i6kx3n6m 63 39 which which WDT cord-347946-i6kx3n6m 63 40 serve serve VBP cord-347946-i6kx3n6m 63 41 to to TO cord-347946-i6kx3n6m 63 42 exacerbate exacerbate VB cord-347946-i6kx3n6m 63 43 the the DT cord-347946-i6kx3n6m 63 44 inflammatory inflammatory JJ cord-347946-i6kx3n6m 63 45 bias bias NN cord-347946-i6kx3n6m 63 46 that that WDT cord-347946-i6kx3n6m 63 47 is be VBZ cord-347946-i6kx3n6m 63 48 the the DT cord-347946-i6kx3n6m 63 49 legacy legacy NN cord-347946-i6kx3n6m 63 50 of of IN cord-347946-i6kx3n6m 63 51 our -PRON- PRP$ cord-347946-i6kx3n6m 63 52 evolutionary evolutionary JJ cord-347946-i6kx3n6m 63 53 past past NN cord-347946-i6kx3n6m 63 54 . . . cord-347946-i6kx3n6m 64 1 Nonetheless nonetheless RB cord-347946-i6kx3n6m 64 2 , , , cord-347946-i6kx3n6m 64 3 cross cross JJ cord-347946-i6kx3n6m 64 4 - - JJ cord-347946-i6kx3n6m 64 5 sectional sectional JJ cord-347946-i6kx3n6m 64 6 associations association NNS cord-347946-i6kx3n6m 64 7 between between IN cord-347946-i6kx3n6m 64 8 MDD MDD NNP cord-347946-i6kx3n6m 64 9 and and CC cord-347946-i6kx3n6m 64 10 inflammation inflammation NN cord-347946-i6kx3n6m 64 11 do do VBP cord-347946-i6kx3n6m 64 12 not not RB cord-347946-i6kx3n6m 64 13 establish establish VB cord-347946-i6kx3n6m 64 14 that that DT cord-347946-i6kx3n6m 64 15 immune immune JJ cord-347946-i6kx3n6m 64 16 system system NN cord-347946-i6kx3n6m 64 17 activity activity NN cord-347946-i6kx3n6m 64 18 is be VBZ cord-347946-i6kx3n6m 64 19 capable capable JJ cord-347946-i6kx3n6m 64 20 of of IN cord-347946-i6kx3n6m 64 21 producing produce VBG cord-347946-i6kx3n6m 64 22 depression depression NN cord-347946-i6kx3n6m 64 23 , , , cord-347946-i6kx3n6m 64 24 as as IN cord-347946-i6kx3n6m 64 25 would would MD cord-347946-i6kx3n6m 64 26 be be VB cord-347946-i6kx3n6m 64 27 predicted predict VBN cord-347946-i6kx3n6m 64 28 by by IN cord-347946-i6kx3n6m 64 29 PATHOS pathos NN cord-347946-i6kx3n6m 64 30 - - HYPH cord-347946-i6kx3n6m 64 31 D d JJ cord-347946-i6kx3n6m 64 32 theory theory NN cord-347946-i6kx3n6m 64 33 . . . cord-347946-i6kx3n6m 65 1 It -PRON- PRP cord-347946-i6kx3n6m 65 2 might may MD cord-347946-i6kx3n6m 65 3 well well RB cord-347946-i6kx3n6m 65 4 be be VB cord-347946-i6kx3n6m 65 5 that that DT cord-347946-i6kx3n6m 65 6 depression depression NN cord-347946-i6kx3n6m 65 7 is be VBZ cord-347946-i6kx3n6m 65 8 associated associate VBN cord-347946-i6kx3n6m 65 9 with with IN cord-347946-i6kx3n6m 65 10 brain brain NN cord-347946-i6kx3n6m 65 11 states state NNS cord-347946-i6kx3n6m 65 12 that that IN cord-347946-i6kx3n6m 65 13 through through IN cord-347946-i6kx3n6m 65 14 their -PRON- PRP$ cord-347946-i6kx3n6m 65 15 impact impact NN cord-347946-i6kx3n6m 65 16 on on IN cord-347946-i6kx3n6m 65 17 neuroendocrine neuroendocrine JJ cord-347946-i6kx3n6m 65 18 function function NN cord-347946-i6kx3n6m 65 19 secondarily secondarily RB cord-347946-i6kx3n6m 65 20 increase increase VBP cord-347946-i6kx3n6m 65 21 inflammatory inflammatory JJ cord-347946-i6kx3n6m 65 22 biomarkers biomarker NNS cord-347946-i6kx3n6m 65 23 that that IN cord-347946-i6kx3n6m 65 24 themselves -PRON- PRP cord-347946-i6kx3n6m 65 25 have have VBP cord-347946-i6kx3n6m 65 26 no no DT cord-347946-i6kx3n6m 65 27 impact impact NN cord-347946-i6kx3n6m 65 28 on on IN cord-347946-i6kx3n6m 65 29 the the DT cord-347946-i6kx3n6m 65 30 disorder disorder NN cord-347946-i6kx3n6m 65 31 . . . cord-347946-i6kx3n6m 66 1 However however RB cord-347946-i6kx3n6m 66 2 , , , cord-347946-i6kx3n6m 66 3 a a DT cord-347946-i6kx3n6m 66 4 wealth wealth NN cord-347946-i6kx3n6m 66 5 of of IN cord-347946-i6kx3n6m 66 6 data datum NNS cord-347946-i6kx3n6m 66 7 demonstrate demonstrate VBP cord-347946-i6kx3n6m 66 8 that that IN cord-347946-i6kx3n6m 66 9 although although IN cord-347946-i6kx3n6m 66 10 it -PRON- PRP cord-347946-i6kx3n6m 66 11 is be VBZ cord-347946-i6kx3n6m 66 12 true true JJ cord-347946-i6kx3n6m 66 13 that that IN cord-347946-i6kx3n6m 66 14 mental mental JJ cord-347946-i6kx3n6m 66 15 states state NNS cord-347946-i6kx3n6m 66 16 can can MD cord-347946-i6kx3n6m 66 17 increase increase VB cord-347946-i6kx3n6m 66 18 inflammation inflammation NN cord-347946-i6kx3n6m 66 19 , , , cord-347946-i6kx3n6m 66 20 it -PRON- PRP cord-347946-i6kx3n6m 66 21 is be VBZ cord-347946-i6kx3n6m 66 22 equally equally RB cord-347946-i6kx3n6m 66 23 true true JJ cord-347946-i6kx3n6m 66 24 that that IN cord-347946-i6kx3n6m 66 25 activation activation NN cord-347946-i6kx3n6m 66 26 of of IN cord-347946-i6kx3n6m 66 27 the the DT cord-347946-i6kx3n6m 66 28 body body NN cord-347946-i6kx3n6m 66 29 's 's POS cord-347946-i6kx3n6m 66 30 inflammatory inflammatory JJ cord-347946-i6kx3n6m 66 31 response response NN cord-347946-i6kx3n6m 66 32 system system NN cord-347946-i6kx3n6m 66 33 can can MD cord-347946-i6kx3n6m 66 34 induce induce VB cord-347946-i6kx3n6m 66 35 depression depression NN cord-347946-i6kx3n6m 66 36 , , , cord-347946-i6kx3n6m 66 37 as as RB cord-347946-i6kx3n6m 66 38 well well RB cord-347946-i6kx3n6m 66 39 as as IN cord-347946-i6kx3n6m 66 40 many many JJ cord-347946-i6kx3n6m 66 41 of of IN cord-347946-i6kx3n6m 66 42 the the DT cord-347946-i6kx3n6m 66 43 CNS CNS NNP cord-347946-i6kx3n6m 66 44 and and CC cord-347946-i6kx3n6m 66 45 neuroendocrine neuroendocrine JJ cord-347946-i6kx3n6m 66 46 changes change NNS cord-347946-i6kx3n6m 66 47 that that WDT cord-347946-i6kx3n6m 66 48 have have VBP cord-347946-i6kx3n6m 66 49 been be VBN cord-347946-i6kx3n6m 66 50 repeatedly repeatedly RB cord-347946-i6kx3n6m 66 51 associated associate VBN cord-347946-i6kx3n6m 66 52 with with IN cord-347946-i6kx3n6m 66 53 MDD MDD NNP cord-347946-i6kx3n6m 66 54 . . . cord-347946-i6kx3n6m 67 1 This this DT cord-347946-i6kx3n6m 67 2 has have VBZ cord-347946-i6kx3n6m 67 3 been be VBN cord-347946-i6kx3n6m 67 4 shown show VBN cord-347946-i6kx3n6m 67 5 in in IN cord-347946-i6kx3n6m 67 6 studies study NNS cord-347946-i6kx3n6m 67 7 examining examine VBG cord-347946-i6kx3n6m 67 8 the the DT cord-347946-i6kx3n6m 67 9 acute acute JJ cord-347946-i6kx3n6m 67 10 behavioral behavioral JJ cord-347946-i6kx3n6m 67 11 and and CC cord-347946-i6kx3n6m 67 12 CNS cns JJ cord-347946-i6kx3n6m 67 13 responses response NNS cord-347946-i6kx3n6m 67 14 to to IN cord-347946-i6kx3n6m 67 15 a a DT cord-347946-i6kx3n6m 67 16 single single JJ cord-347946-i6kx3n6m 67 17 exposure exposure NN cord-347946-i6kx3n6m 67 18 to to IN cord-347946-i6kx3n6m 67 19 endotoxin endotoxin NN cord-347946-i6kx3n6m 67 20 or or CC cord-347946-i6kx3n6m 67 21 typhoid typhoid NN cord-347946-i6kx3n6m 67 22 vaccine vaccine NN cord-347946-i6kx3n6m 67 23 and and CC cord-347946-i6kx3n6m 67 24 even even RB cord-347946-i6kx3n6m 67 25 more more RBR cord-347946-i6kx3n6m 67 26 convincingly convincingly RB cord-347946-i6kx3n6m 67 27 by by IN cord-347946-i6kx3n6m 67 28 the the DT cord-347946-i6kx3n6m 67 29 many many JJ cord-347946-i6kx3n6m 67 30 studies study NNS cord-347946-i6kx3n6m 67 31 examining examine VBG cord-347946-i6kx3n6m 67 32 the the DT cord-347946-i6kx3n6m 67 33 biological biological JJ cord-347946-i6kx3n6m 67 34 and and CC cord-347946-i6kx3n6m 67 35 behavioral behavioral JJ cord-347946-i6kx3n6m 67 36 effects effect NNS cord-347946-i6kx3n6m 67 37 of of IN cord-347946-i6kx3n6m 67 38 chronic chronic JJ cord-347946-i6kx3n6m 67 39 immune immune JJ cord-347946-i6kx3n6m 67 40 activation activation NN cord-347946-i6kx3n6m 67 41 secondary secondary JJ cord-347946-i6kx3n6m 67 42 to to IN cord-347946-i6kx3n6m 67 43 treatment treatment NN cord-347946-i6kx3n6m 67 44 with with IN cord-347946-i6kx3n6m 67 45 the the DT cord-347946-i6kx3n6m 67 46 cytokine cytokine NN cord-347946-i6kx3n6m 67 47 IFN IFN NNP cord-347946-i6kx3n6m 67 48 - - HYPH cord-347946-i6kx3n6m 67 49 α α NN cord-347946-i6kx3n6m 67 50 for for IN cord-347946-i6kx3n6m 67 51 either either CC cord-347946-i6kx3n6m 67 52 cancer cancer NN cord-347946-i6kx3n6m 67 53 or or CC cord-347946-i6kx3n6m 67 54 hepatitis hepatitis NN cord-347946-i6kx3n6m 67 55 C C NNP cord-347946-i6kx3n6m 67 56 virus virus NN cord-347946-i6kx3n6m 67 57 infection infection NN cord-347946-i6kx3n6m 68 1 ( ( -LRB- cord-347946-i6kx3n6m 68 2 Capuron Capuron NNP cord-347946-i6kx3n6m 68 3 et et NNP cord-347946-i6kx3n6m 68 4 al al NNP cord-347946-i6kx3n6m 68 5 , , , cord-347946-i6kx3n6m 68 6 2002 2002 CD cord-347946-i6kx3n6m 69 1 ( ( -LRB- cord-347946-i6kx3n6m 69 2 Capuron Capuron NNP cord-347946-i6kx3n6m 69 3 et et NNP cord-347946-i6kx3n6m 69 4 al al NNP cord-347946-i6kx3n6m 69 5 , , , cord-347946-i6kx3n6m 69 6 , , , cord-347946-i6kx3n6m 69 7 2003a 2003a CD cord-347946-i6kx3n6m 70 1 ( ( -LRB- cord-347946-i6kx3n6m 70 2 Capuron Capuron NNP cord-347946-i6kx3n6m 70 3 et et NNP cord-347946-i6kx3n6m 70 4 al al NNP cord-347946-i6kx3n6m 70 5 , , , cord-347946-i6kx3n6m 70 6 , , , cord-347946-i6kx3n6m 70 7 2003b 2003b CD cord-347946-i6kx3n6m 71 1 ( ( -LRB- cord-347946-i6kx3n6m 71 2 Capuron Capuron NNP cord-347946-i6kx3n6m 71 3 et et NNP cord-347946-i6kx3n6m 71 4 al al NNP cord-347946-i6kx3n6m 71 5 , , , cord-347946-i6kx3n6m 71 6 , , , cord-347946-i6kx3n6m 71 7 2005 2005 CD cord-347946-i6kx3n6m 72 1 ( ( -LRB- cord-347946-i6kx3n6m 72 2 Capuron Capuron NNP cord-347946-i6kx3n6m 72 3 et et NNP cord-347946-i6kx3n6m 72 4 al al NNP cord-347946-i6kx3n6m 72 5 , , , cord-347946-i6kx3n6m 72 6 , , , cord-347946-i6kx3n6m 72 7 2007 2007 CD cord-347946-i6kx3n6m 73 1 ( ( -LRB- cord-347946-i6kx3n6m 73 2 Capuron Capuron NNP cord-347946-i6kx3n6m 73 3 et et NNP cord-347946-i6kx3n6m 73 4 al al NNP cord-347946-i6kx3n6m 73 5 , , , cord-347946-i6kx3n6m 73 6 , , , cord-347946-i6kx3n6m 73 7 2009 2009 CD cord-347946-i6kx3n6m 73 8 Wichers Wichers NNPS cord-347946-i6kx3n6m 73 9 and and CC cord-347946-i6kx3n6m 73 10 Maes Maes NNP cord-347946-i6kx3n6m 73 11 , , , cord-347946-i6kx3n6m 73 12 2004 2004 CD cord-347946-i6kx3n6m 73 13 ; ; : cord-347946-i6kx3n6m 73 14 Wichers Wichers NNP cord-347946-i6kx3n6m 73 15 et et NNP cord-347946-i6kx3n6m 73 16 al al NNP cord-347946-i6kx3n6m 73 17 , , , cord-347946-i6kx3n6m 73 18 2005b 2005b CD cord-347946-i6kx3n6m 73 19 Wichers Wichers NNPS cord-347946-i6kx3n6m 73 20 et et NNP cord-347946-i6kx3n6m 73 21 al al NNP cord-347946-i6kx3n6m 73 22 , , , cord-347946-i6kx3n6m 73 23 , , , cord-347946-i6kx3n6m 73 24 2006 2006 CD cord-347946-i6kx3n6m 73 25 Wichers Wichers NNPS cord-347946-i6kx3n6m 73 26 et et NNP cord-347946-i6kx3n6m 73 27 al al NNP cord-347946-i6kx3n6m 73 28 , , , cord-347946-i6kx3n6m 73 29 , , , cord-347946-i6kx3n6m 73 30 2007 2007 CD cord-347946-i6kx3n6m 73 31 Majer Majer NNP cord-347946-i6kx3n6m 73 32 et et NNP cord-347946-i6kx3n6m 73 33 al al NNP cord-347946-i6kx3n6m 73 34 , , , cord-347946-i6kx3n6m 73 35 2008 2008 CD cord-347946-i6kx3n6m 73 36 ; ; : cord-347946-i6kx3n6m 73 37 Harrison Harrison NNP cord-347946-i6kx3n6m 73 38 et et NNP cord-347946-i6kx3n6m 73 39 al al NNP cord-347946-i6kx3n6m 73 40 , , , cord-347946-i6kx3n6m 73 41 2009a 2009a CD cord-347946-i6kx3n6m 73 42 Harrison Harrison NNP cord-347946-i6kx3n6m 73 43 et et NNP cord-347946-i6kx3n6m 73 44 al al NNP cord-347946-i6kx3n6m 73 45 , , , cord-347946-i6kx3n6m 73 46 , , , cord-347946-i6kx3n6m 73 47 2009b 2009b CD cord-347946-i6kx3n6m 73 48 Lotrich Lotrich NNP cord-347946-i6kx3n6m 73 49 , , , cord-347946-i6kx3n6m 73 50 2009 2009 CD cord-347946-i6kx3n6m 73 51 ; ; : cord-347946-i6kx3n6m 73 52 Lotrich Lotrich NNP cord-347946-i6kx3n6m 73 53 et et NNP cord-347946-i6kx3n6m 73 54 al al NNP cord-347946-i6kx3n6m 73 55 , , , cord-347946-i6kx3n6m 73 56 2009 2009 CD cord-347946-i6kx3n6m 73 57 ; ; : cord-347946-i6kx3n6m 73 58 Prather Prather NNP cord-347946-i6kx3n6m 73 59 et et NNP cord-347946-i6kx3n6m 73 60 al al NNP cord-347946-i6kx3n6m 73 61 , , , cord-347946-i6kx3n6m 73 62 2009 2009 CD cord-347946-i6kx3n6m 73 63 ; ; : cord-347946-i6kx3n6m 73 64 Raison Raison NNP cord-347946-i6kx3n6m 73 65 et et NNP cord-347946-i6kx3n6m 73 66 al al NNP cord-347946-i6kx3n6m 73 67 , , , cord-347946-i6kx3n6m 73 68 2009 2009 CD cord-347946-i6kx3n6m 73 69 Raison Raison NNP cord-347946-i6kx3n6m 73 70 et et NNP cord-347946-i6kx3n6m 73 71 al al NNP cord-347946-i6kx3n6m 73 72 , , , cord-347946-i6kx3n6m 73 73 , , , cord-347946-i6kx3n6m 73 74 2010a 2010a NNS cord-347946-i6kx3n6m 73 75 Raison Raison NNP cord-347946-i6kx3n6m 73 76 et et NNP cord-347946-i6kx3n6m 73 77 al al NNP cord-347946-i6kx3n6m 73 78 , , , cord-347946-i6kx3n6m 73 79 , , , cord-347946-i6kx3n6m 73 80 2010b 2010b CD cord-347946-i6kx3n6m 73 81 Raison Raison NNP cord-347946-i6kx3n6m 73 82 et et NNP cord-347946-i6kx3n6m 73 83 al al NNP cord-347946-i6kx3n6m 73 84 , , , cord-347946-i6kx3n6m 73 85 , , , cord-347946-i6kx3n6m 73 86 2010d 2010d CD cord-347946-i6kx3n6m 73 87 Eisenberger Eisenberger NNP cord-347946-i6kx3n6m 73 88 et et NNP cord-347946-i6kx3n6m 73 89 al al NNP cord-347946-i6kx3n6m 73 90 , , , cord-347946-i6kx3n6m 73 91 2010a 2010a CD cord-347946-i6kx3n6m 73 92 , , , cord-347946-i6kx3n6m 73 93 b b LS cord-347946-i6kx3n6m 73 94 ; ; : cord-347946-i6kx3n6m 73 95 Franzen Franzen NNP cord-347946-i6kx3n6m 73 96 et et NNP cord-347946-i6kx3n6m 73 97 al al NNP cord-347946-i6kx3n6m 73 98 , , , cord-347946-i6kx3n6m 73 99 2010 2010 CD cord-347946-i6kx3n6m 73 100 ; ; : cord-347946-i6kx3n6m 73 101 Felger Felger NNP cord-347946-i6kx3n6m 73 102 et et NNP cord-347946-i6kx3n6m 73 103 al al NNP cord-347946-i6kx3n6m 73 104 , , , cord-347946-i6kx3n6m 73 105 2011 2011 CD cord-347946-i6kx3n6m 73 106 Felger Felger NNP cord-347946-i6kx3n6m 73 107 et et NNP cord-347946-i6kx3n6m 73 108 al al NNP cord-347946-i6kx3n6m 73 109 , , , cord-347946-i6kx3n6m 73 110 , , , cord-347946-i6kx3n6m 73 111 2012 2012 CD cord-347946-i6kx3n6m 73 112 . . . cord-347946-i6kx3n6m 74 1 Importantly importantly RB cord-347946-i6kx3n6m 74 2 , , , cord-347946-i6kx3n6m 74 3 the the DT cord-347946-i6kx3n6m 74 4 induction induction NN cord-347946-i6kx3n6m 74 5 of of IN cord-347946-i6kx3n6m 74 6 depressed depressed JJ cord-347946-i6kx3n6m 74 7 mood mood NN cord-347946-i6kx3n6m 74 8 in in IN cord-347946-i6kx3n6m 74 9 response response NN cord-347946-i6kx3n6m 74 10 to to IN cord-347946-i6kx3n6m 74 11 both both CC cord-347946-i6kx3n6m 74 12 acute acute JJ cord-347946-i6kx3n6m 74 13 ( ( -LRB- cord-347946-i6kx3n6m 74 14 ie ie FW cord-347946-i6kx3n6m 74 15 , , , cord-347946-i6kx3n6m 74 16 typhoid typhoid NN cord-347946-i6kx3n6m 74 17 vaccine vaccine NN cord-347946-i6kx3n6m 74 18 ) ) -RRB- cord-347946-i6kx3n6m 74 19 and and CC cord-347946-i6kx3n6m 74 20 chronic chronic JJ cord-347946-i6kx3n6m 74 21 ( ( -LRB- cord-347946-i6kx3n6m 74 22 ie ie FW cord-347946-i6kx3n6m 74 23 , , , cord-347946-i6kx3n6m 74 24 IFN IFN NNP cord-347946-i6kx3n6m 74 25 - - HYPH cord-347946-i6kx3n6m 74 26 α α NNP cord-347946-i6kx3n6m 74 27 ) ) -RRB- cord-347946-i6kx3n6m 74 28 immune immune JJ cord-347946-i6kx3n6m 74 29 stimulation stimulation NN cord-347946-i6kx3n6m 74 30 has have VBZ cord-347946-i6kx3n6m 74 31 been be VBN cord-347946-i6kx3n6m 74 32 associated associate VBN cord-347946-i6kx3n6m 74 33 with with IN cord-347946-i6kx3n6m 74 34 increased increase VBN cord-347946-i6kx3n6m 74 35 concentrations concentration NNS cord-347946-i6kx3n6m 74 36 of of IN cord-347946-i6kx3n6m 74 37 circulating circulate VBG cord-347946-i6kx3n6m 74 38 inflammatory inflammatory JJ cord-347946-i6kx3n6m 74 39 cytokines cytokine NNS cord-347946-i6kx3n6m 74 40 ( ( -LRB- cord-347946-i6kx3n6m 74 41 Wright Wright NNP cord-347946-i6kx3n6m 74 42 et et NNP cord-347946-i6kx3n6m 74 43 al al NNP cord-347946-i6kx3n6m 74 44 , , , cord-347946-i6kx3n6m 74 45 2005 2005 CD cord-347946-i6kx3n6m 74 46 ; ; : cord-347946-i6kx3n6m 74 47 Raison Raison NNP cord-347946-i6kx3n6m 74 48 et et NNP cord-347946-i6kx3n6m 74 49 al al NNP cord-347946-i6kx3n6m 74 50 , , , cord-347946-i6kx3n6m 74 51 2010a 2010a CD cord-347946-i6kx3n6m 74 52 ) ) -RRB- cord-347946-i6kx3n6m 74 53 . . . cord-347946-i6kx3n6m 75 1 Also also RB cord-347946-i6kx3n6m 75 2 consistent consistent JJ cord-347946-i6kx3n6m 75 3 with with IN cord-347946-i6kx3n6m 75 4 the the DT cord-347946-i6kx3n6m 75 5 ability ability NN cord-347946-i6kx3n6m 75 6 of of IN cord-347946-i6kx3n6m 75 7 immune immune JJ cord-347946-i6kx3n6m 75 8 activation activation NN cord-347946-i6kx3n6m 75 9 / / SYM cord-347946-i6kx3n6m 75 10 inflammation inflammation NN cord-347946-i6kx3n6m 75 11 to to TO cord-347946-i6kx3n6m 75 12 negatively negatively RB cord-347946-i6kx3n6m 75 13 impact impact VB cord-347946-i6kx3n6m 75 14 mood mood NN cord-347946-i6kx3n6m 75 15 is be VBZ cord-347946-i6kx3n6m 75 16 the the DT cord-347946-i6kx3n6m 75 17 fact fact NN cord-347946-i6kx3n6m 75 18 that that IN cord-347946-i6kx3n6m 75 19 the the DT cord-347946-i6kx3n6m 75 20 risk risk NN cord-347946-i6kx3n6m 75 21 of of IN cord-347946-i6kx3n6m 75 22 developing develop VBG cord-347946-i6kx3n6m 75 23 MDD MDD NNP cord-347946-i6kx3n6m 75 24 , , , cord-347946-i6kx3n6m 75 25 increases increase VBZ cord-347946-i6kx3n6m 75 26 following follow VBG cord-347946-i6kx3n6m 75 27 significant significant JJ cord-347946-i6kx3n6m 75 28 infections infection NNS cord-347946-i6kx3n6m 75 29 ( ( -LRB- cord-347946-i6kx3n6m 75 30 Benros Benros NNP cord-347946-i6kx3n6m 75 31 et et NNP cord-347946-i6kx3n6m 75 32 al al NNP cord-347946-i6kx3n6m 75 33 , , , cord-347946-i6kx3n6m 75 34 2013 2013 CD cord-347946-i6kx3n6m 75 35 ; ; : cord-347946-i6kx3n6m 75 36 Gunaratne Gunaratne NNP cord-347946-i6kx3n6m 75 37 et et FW cord-347946-i6kx3n6m 75 38 al al NNP cord-347946-i6kx3n6m 75 39 , , , cord-347946-i6kx3n6m 75 40 2013 2013 CD cord-347946-i6kx3n6m 75 41 ; ; : cord-347946-i6kx3n6m 75 42 Bornand Bornand NNP cord-347946-i6kx3n6m 75 43 et et NNP cord-347946-i6kx3n6m 75 44 al al NNP cord-347946-i6kx3n6m 75 45 , , , cord-347946-i6kx3n6m 75 46 2016 2016 CD cord-347946-i6kx3n6m 75 47 ) ) -RRB- cord-347946-i6kx3n6m 75 48 . . . cord-347946-i6kx3n6m 76 1 Finally finally RB cord-347946-i6kx3n6m 76 2 , , , cord-347946-i6kx3n6m 76 3 a a DT cord-347946-i6kx3n6m 76 4 recent recent JJ cord-347946-i6kx3n6m 76 5 meta meta JJ cord-347946-i6kx3n6m 76 6 - - HYPH cord-347946-i6kx3n6m 76 7 analysis analysis NN cord-347946-i6kx3n6m 76 8 confirms confirm VBZ cord-347946-i6kx3n6m 76 9 findings finding NNS cord-347946-i6kx3n6m 76 10 from from IN cord-347946-i6kx3n6m 76 11 a a DT cord-347946-i6kx3n6m 76 12 number number NN cord-347946-i6kx3n6m 76 13 of of IN cord-347946-i6kx3n6m 76 14 individual individual JJ cord-347946-i6kx3n6m 76 15 studies study NNS cord-347946-i6kx3n6m 76 16 that that WDT cord-347946-i6kx3n6m 76 17 elevated elevated JJ cord-347946-i6kx3n6m 76 18 levels level NNS cord-347946-i6kx3n6m 76 19 of of IN cord-347946-i6kx3n6m 76 20 circulating circulate VBG cord-347946-i6kx3n6m 76 21 inflammatory inflammatory JJ cord-347946-i6kx3n6m 76 22 biomarkers biomarker NNS cord-347946-i6kx3n6m 76 23 predict predict VBP cord-347946-i6kx3n6m 76 24 the the DT cord-347946-i6kx3n6m 76 25 future future JJ cord-347946-i6kx3n6m 76 26 development development NN cord-347946-i6kx3n6m 76 27 of of IN cord-347946-i6kx3n6m 76 28 depression depression NN cord-347946-i6kx3n6m 76 29 in in IN cord-347946-i6kx3n6m 76 30 currently currently RB cord-347946-i6kx3n6m 76 31 non non JJ cord-347946-i6kx3n6m 76 32 - - JJ cord-347946-i6kx3n6m 76 33 depressed depressed JJ cord-347946-i6kx3n6m 76 34 individuals individual NNS cord-347946-i6kx3n6m 76 35 , , , cord-347946-i6kx3n6m 76 36 even even RB cord-347946-i6kx3n6m 76 37 when when WRB cord-347946-i6kx3n6m 76 38 controlling control VBG cord-347946-i6kx3n6m 76 39 for for IN cord-347946-i6kx3n6m 76 40 other other JJ cord-347946-i6kx3n6m 76 41 depressive depressive JJ cord-347946-i6kx3n6m 76 42 risk risk NN cord-347946-i6kx3n6m 76 43 factors factor NNS cord-347946-i6kx3n6m 76 44 ( ( -LRB- cord-347946-i6kx3n6m 76 45 Valkanova Valkanova NNP cord-347946-i6kx3n6m 76 46 et et NNP cord-347946-i6kx3n6m 76 47 al al NNP cord-347946-i6kx3n6m 76 48 , , , cord-347946-i6kx3n6m 76 49 2013 2013 CD cord-347946-i6kx3n6m 76 50 ) ) -RRB- cord-347946-i6kx3n6m 76 51 . . . cord-347946-i6kx3n6m 77 1 Increased increase VBN cord-347946-i6kx3n6m 77 2 inflammatory inflammatory JJ cord-347946-i6kx3n6m 77 3 activity activity NN cord-347946-i6kx3n6m 77 4 has have VBZ cord-347946-i6kx3n6m 77 5 been be VBN cord-347946-i6kx3n6m 77 6 the the DT cord-347946-i6kx3n6m 77 7 most most RBS cord-347946-i6kx3n6m 77 8 replicated replicate VBN cord-347946-i6kx3n6m 77 9 immune immune JJ cord-347946-i6kx3n6m 77 10 change change NN cord-347946-i6kx3n6m 77 11 associated associate VBN cord-347946-i6kx3n6m 77 12 with with IN cord-347946-i6kx3n6m 77 13 MDD MDD NNP cord-347946-i6kx3n6m 77 14 , , , cord-347946-i6kx3n6m 77 15 but but CC cord-347946-i6kx3n6m 77 16 there there EX cord-347946-i6kx3n6m 77 17 is be VBZ cord-347946-i6kx3n6m 77 18 no no DT cord-347946-i6kx3n6m 77 19 a a FW cord-347946-i6kx3n6m 77 20 priori priori JJ cord-347946-i6kx3n6m 77 21 reason reason NN cord-347946-i6kx3n6m 77 22 why why WRB cord-347946-i6kx3n6m 77 23 this this DT cord-347946-i6kx3n6m 77 24 should should MD cord-347946-i6kx3n6m 77 25 be be VB cord-347946-i6kx3n6m 77 26 the the DT cord-347946-i6kx3n6m 77 27 only only JJ cord-347946-i6kx3n6m 77 28 adaptive adaptive JJ cord-347946-i6kx3n6m 77 29 immune immune JJ cord-347946-i6kx3n6m 77 30 pattern pattern NN cord-347946-i6kx3n6m 77 31 associated associate VBN cord-347946-i6kx3n6m 77 32 with with IN cord-347946-i6kx3n6m 77 33 depression depression NN cord-347946-i6kx3n6m 77 34 that that WDT cord-347946-i6kx3n6m 77 35 enhanced enhance VBD cord-347946-i6kx3n6m 77 36 pathogen pathogen NN cord-347946-i6kx3n6m 77 37 - - HYPH cord-347946-i6kx3n6m 77 38 host host NN cord-347946-i6kx3n6m 77 39 defense defense NN cord-347946-i6kx3n6m 77 40 . . . cord-347946-i6kx3n6m 78 1 A a DT cord-347946-i6kx3n6m 78 2 clear clear JJ cord-347946-i6kx3n6m 78 3 prediction prediction NN cord-347946-i6kx3n6m 78 4 of of IN cord-347946-i6kx3n6m 78 5 PATHOS pathos NN cord-347946-i6kx3n6m 78 6 - - HYPH cord-347946-i6kx3n6m 78 7 D d JJ cord-347946-i6kx3n6m 78 8 theory theory NN cord-347946-i6kx3n6m 78 9 is be VBZ cord-347946-i6kx3n6m 78 10 that that IN cord-347946-i6kx3n6m 78 11 as as IN cord-347946-i6kx3n6m 78 12 novel novel JJ cord-347946-i6kx3n6m 78 13 innate innate JJ cord-347946-i6kx3n6m 78 14 immune immune JJ cord-347946-i6kx3n6m 78 15 antipathogenic antipathogenic NN cord-347946-i6kx3n6m 78 16 mechanisms mechanism NNS cord-347946-i6kx3n6m 78 17 are be VBP cord-347946-i6kx3n6m 78 18 identified identify VBN cord-347946-i6kx3n6m 78 19 , , , cord-347946-i6kx3n6m 78 20 they -PRON- PRP cord-347946-i6kx3n6m 78 21 will will MD cord-347946-i6kx3n6m 78 22 be be VB cord-347946-i6kx3n6m 78 23 found find VBN cord-347946-i6kx3n6m 78 24 to to TO cord-347946-i6kx3n6m 78 25 be be VB cord-347946-i6kx3n6m 78 26 enhanced enhance VBN cord-347946-i6kx3n6m 78 27 in in IN cord-347946-i6kx3n6m 78 28 depressed depressed JJ cord-347946-i6kx3n6m 78 29 individuals individual NNS cord-347946-i6kx3n6m 78 30 . . . cord-347946-i6kx3n6m 79 1 For for IN cord-347946-i6kx3n6m 79 2 example example NN cord-347946-i6kx3n6m 79 3 , , , cord-347946-i6kx3n6m 79 4 recent recent JJ cord-347946-i6kx3n6m 79 5 studies study NNS cord-347946-i6kx3n6m 79 6 indicate indicate VBP cord-347946-i6kx3n6m 79 7 that that IN cord-347946-i6kx3n6m 79 8 antimicrobial antimicrobial JJ cord-347946-i6kx3n6m 79 9 peptides peptide NNS cord-347946-i6kx3n6m 79 10 upregulated upregulate VBN cord-347946-i6kx3n6m 79 11 by by IN cord-347946-i6kx3n6m 79 12 inflammatory inflammatory JJ cord-347946-i6kx3n6m 79 13 cytokines cytokine NNS cord-347946-i6kx3n6m 79 14 ( ( -LRB- cord-347946-i6kx3n6m 79 15 eg eg RB cord-347946-i6kx3n6m 79 16 , , , cord-347946-i6kx3n6m 79 17 ribonuclease ribonuclease NNP cord-347946-i6kx3n6m 79 18 7 7 CD cord-347946-i6kx3n6m 79 19 , , , cord-347946-i6kx3n6m 79 20 psoriasin psoriasin NNP cord-347946-i6kx3n6m 79 21 , , , cord-347946-i6kx3n6m 79 22 and and CC cord-347946-i6kx3n6m 79 23 human human JJ cord-347946-i6kx3n6m 79 24 β β NNP cord-347946-i6kx3n6m 79 25 - - HYPH cord-347946-i6kx3n6m 79 26 defensin-2 defensin-2 NNP cord-347946-i6kx3n6m 79 27 and and CC cord-347946-i6kx3n6m 79 28 3 3 CD cord-347946-i6kx3n6m 79 29 ; ; : cord-347946-i6kx3n6m 79 30 Harder Harder NNP cord-347946-i6kx3n6m 79 31 et et NNP cord-347946-i6kx3n6m 79 32 al al NNP cord-347946-i6kx3n6m 79 33 , , , cord-347946-i6kx3n6m 79 34 2007 2007 CD cord-347946-i6kx3n6m 79 35 ) ) -RRB- cord-347946-i6kx3n6m 79 36 are be VBP cord-347946-i6kx3n6m 79 37 increased increase VBN cord-347946-i6kx3n6m 79 38 in in IN cord-347946-i6kx3n6m 79 39 the the DT cord-347946-i6kx3n6m 79 40 skin skin NN cord-347946-i6kx3n6m 79 41 of of IN cord-347946-i6kx3n6m 79 42 patients patient NNS cord-347946-i6kx3n6m 79 43 with with IN cord-347946-i6kx3n6m 79 44 inflammatory inflammatory JJ cord-347946-i6kx3n6m 79 45 skin skin NN cord-347946-i6kx3n6m 79 46 conditions condition NNS cord-347946-i6kx3n6m 79 47 , , , cord-347946-i6kx3n6m 79 48 such such JJ cord-347946-i6kx3n6m 79 49 as as IN cord-347946-i6kx3n6m 79 50 atopic atopic JJ cord-347946-i6kx3n6m 79 51 dermatitis dermatitis NN cord-347946-i6kx3n6m 79 52 and and CC cord-347946-i6kx3n6m 79 53 psoriasis psoriasis NN cord-347946-i6kx3n6m 79 54 ( ( -LRB- cord-347946-i6kx3n6m 80 1 Harder Harder NNP cord-347946-i6kx3n6m 80 2 and and CC cord-347946-i6kx3n6m 80 3 Schroder Schroder NNP cord-347946-i6kx3n6m 80 4 , , , cord-347946-i6kx3n6m 80 5 2005 2005 CD cord-347946-i6kx3n6m 80 6 ; ; : cord-347946-i6kx3n6m 80 7 Harder Harder NNP cord-347946-i6kx3n6m 80 8 et et NNP cord-347946-i6kx3n6m 80 9 al al NNP cord-347946-i6kx3n6m 80 10 , , , cord-347946-i6kx3n6m 80 11 2010 2010 CD cord-347946-i6kx3n6m 80 12 ) ) -RRB- cord-347946-i6kx3n6m 80 13 , , , cord-347946-i6kx3n6m 80 14 that that WDT cord-347946-i6kx3n6m 80 15 are be VBP cord-347946-i6kx3n6m 80 16 comorbid comorbid JJ cord-347946-i6kx3n6m 80 17 with with IN cord-347946-i6kx3n6m 80 18 MDD MDD NNP cord-347946-i6kx3n6m 81 1 ( ( -LRB- cord-347946-i6kx3n6m 81 2 Gili Gili NNP cord-347946-i6kx3n6m 81 3 et et NNP cord-347946-i6kx3n6m 81 4 al al NNP cord-347946-i6kx3n6m 81 5 , , , cord-347946-i6kx3n6m 81 6 2010 2010 CD cord-347946-i6kx3n6m 81 7 ; ; : cord-347946-i6kx3n6m 81 8 Yang Yang NNP cord-347946-i6kx3n6m 81 9 et et NNP cord-347946-i6kx3n6m 81 10 al al NNP cord-347946-i6kx3n6m 81 11 , , , cord-347946-i6kx3n6m 81 12 2010 2010 CD cord-347946-i6kx3n6m 81 13 ) ) -RRB- cord-347946-i6kx3n6m 81 14 . . . cord-347946-i6kx3n6m 82 1 One one PRP cord-347946-i6kx3n6m 82 2 would would MD cord-347946-i6kx3n6m 82 3 expect expect VB cord-347946-i6kx3n6m 82 4 a a DT cord-347946-i6kx3n6m 82 5 similar similar JJ cord-347946-i6kx3n6m 82 6 increase increase NN cord-347946-i6kx3n6m 82 7 in in IN cord-347946-i6kx3n6m 82 8 these these DT cord-347946-i6kx3n6m 82 9 peptides peptide NNS cord-347946-i6kx3n6m 82 10 - - : cord-347946-i6kx3n6m 82 11 although although IN cord-347946-i6kx3n6m 82 12 perhaps perhaps RB cord-347946-i6kx3n6m 82 13 to to IN cord-347946-i6kx3n6m 82 14 a a DT cord-347946-i6kx3n6m 82 15 lesser less JJR cord-347946-i6kx3n6m 82 16 degree degree NN cord-347946-i6kx3n6m 82 17 - - : cord-347946-i6kx3n6m 82 18 in in NN cord-347946-i6kx3n6m 82 19 medically medically RB cord-347946-i6kx3n6m 82 20 healthy healthy JJ cord-347946-i6kx3n6m 82 21 individuals individual NNS cord-347946-i6kx3n6m 82 22 with with IN cord-347946-i6kx3n6m 82 23 MDD MDD NNP cord-347946-i6kx3n6m 82 24 . . . cord-347946-i6kx3n6m 83 1 The the DT cord-347946-i6kx3n6m 83 2 best good JJS cord-347946-i6kx3n6m 83 3 replicated replicate VBN cord-347946-i6kx3n6m 83 4 risk risk NN cord-347946-i6kx3n6m 83 5 factors factor NNS cord-347946-i6kx3n6m 83 6 for for IN cord-347946-i6kx3n6m 83 7 MDD MDD NNP cord-347946-i6kx3n6m 83 8 in in IN cord-347946-i6kx3n6m 83 9 the the DT cord-347946-i6kx3n6m 83 10 modern modern JJ cord-347946-i6kx3n6m 83 11 world world NN cord-347946-i6kx3n6m 83 12 have have VBP cord-347946-i6kx3n6m 83 13 been be VBN cord-347946-i6kx3n6m 83 14 repeatedly repeatedly RB cord-347946-i6kx3n6m 83 15 associated associate VBN cord-347946-i6kx3n6m 83 16 with with IN cord-347946-i6kx3n6m 83 17 the the DT cord-347946-i6kx3n6m 83 18 same same JJ cord-347946-i6kx3n6m 83 19 changes change NNS cord-347946-i6kx3n6m 83 20 in in IN cord-347946-i6kx3n6m 83 21 immune immune JJ cord-347946-i6kx3n6m 83 22 functioning functioning NN cord-347946-i6kx3n6m 83 23 that that WDT cord-347946-i6kx3n6m 83 24 are be VBP cord-347946-i6kx3n6m 83 25 observed observe VBN cord-347946-i6kx3n6m 83 26 in in IN cord-347946-i6kx3n6m 83 27 MDD MDD NNP cord-347946-i6kx3n6m 83 28 ( ( -LRB- cord-347946-i6kx3n6m 83 29 Raison Raison NNP cord-347946-i6kx3n6m 83 30 , , , cord-347946-i6kx3n6m 83 31 et et NNP cord-347946-i6kx3n6m 83 32 al al NNP cord-347946-i6kx3n6m 83 33 , , , cord-347946-i6kx3n6m 83 34 2010c 2010c CD cord-347946-i6kx3n6m 83 35 ) ) -RRB- cord-347946-i6kx3n6m 83 36 . . . cord-347946-i6kx3n6m 84 1 This this DT cord-347946-i6kx3n6m 84 2 is be VBZ cord-347946-i6kx3n6m 84 3 especially especially RB cord-347946-i6kx3n6m 84 4 apparent apparent JJ cord-347946-i6kx3n6m 84 5 in in IN cord-347946-i6kx3n6m 84 6 relation relation NN cord-347946-i6kx3n6m 84 7 to to IN cord-347946-i6kx3n6m 84 8 associations association NNS cord-347946-i6kx3n6m 84 9 between between IN cord-347946-i6kx3n6m 84 10 these these DT cord-347946-i6kx3n6m 84 11 risk risk NN cord-347946-i6kx3n6m 84 12 factors factor NNS cord-347946-i6kx3n6m 84 13 and and CC cord-347946-i6kx3n6m 84 14 increased increase VBN cord-347946-i6kx3n6m 84 15 inflammation inflammation NN cord-347946-i6kx3n6m 84 16 ; ; : cord-347946-i6kx3n6m 84 17 however however RB cord-347946-i6kx3n6m 84 18 , , , cord-347946-i6kx3n6m 84 19 stress stress NN cord-347946-i6kx3n6m 84 20 - - : cord-347946-i6kx3n6m 84 21 which which WDT cord-347946-i6kx3n6m 84 22 has have VBZ cord-347946-i6kx3n6m 84 23 been be VBN cord-347946-i6kx3n6m 84 24 the the DT cord-347946-i6kx3n6m 84 25 most most RBS cord-347946-i6kx3n6m 84 26 extensively extensively RB cord-347946-i6kx3n6m 84 27 studied study VBN cord-347946-i6kx3n6m 84 28 - - : cord-347946-i6kx3n6m 84 29 has have VBZ cord-347946-i6kx3n6m 84 30 also also RB cord-347946-i6kx3n6m 84 31 been be VBN cord-347946-i6kx3n6m 84 32 repeatedly repeatedly RB cord-347946-i6kx3n6m 84 33 associated associate VBN cord-347946-i6kx3n6m 84 34 with with IN cord-347946-i6kx3n6m 84 35 other other JJ cord-347946-i6kx3n6m 84 36 immune immune JJ cord-347946-i6kx3n6m 84 37 changes change NNS cord-347946-i6kx3n6m 84 38 seen see VBN cord-347946-i6kx3n6m 84 39 in in IN cord-347946-i6kx3n6m 84 40 MDD MDD NNP cord-347946-i6kx3n6m 84 41 ( ( -LRB- cord-347946-i6kx3n6m 84 42 Herbert Herbert NNP cord-347946-i6kx3n6m 84 43 and and CC cord-347946-i6kx3n6m 84 44 Cohen Cohen NNP cord-347946-i6kx3n6m 84 45 , , , cord-347946-i6kx3n6m 84 46 1993a 1993a CD cord-347946-i6kx3n6m 84 47 , , , cord-347946-i6kx3n6m 84 48 b b LS cord-347946-i6kx3n6m 84 49 ) ) -RRB- cord-347946-i6kx3n6m 84 50 . . . cord-347946-i6kx3n6m 85 1 Taken take VBN cord-347946-i6kx3n6m 85 2 at at IN cord-347946-i6kx3n6m 85 3 face face NN cord-347946-i6kx3n6m 85 4 value value NN cord-347946-i6kx3n6m 85 5 , , , cord-347946-i6kx3n6m 85 6 these these DT cord-347946-i6kx3n6m 85 7 associations association NNS cord-347946-i6kx3n6m 85 8 appear appear VBP cord-347946-i6kx3n6m 85 9 to to TO cord-347946-i6kx3n6m 85 10 provide provide VB cord-347946-i6kx3n6m 85 11 strong strong JJ cord-347946-i6kx3n6m 85 12 support support NN cord-347946-i6kx3n6m 85 13 for for IN cord-347946-i6kx3n6m 85 14 PATHOS PATHOS NNP cord-347946-i6kx3n6m 85 15 - - HYPH cord-347946-i6kx3n6m 85 16 D. D. NNP cord-347946-i6kx3n6m 86 1 However however RB cord-347946-i6kx3n6m 86 2 , , , cord-347946-i6kx3n6m 86 3 it -PRON- PRP cord-347946-i6kx3n6m 86 4 is be VBZ cord-347946-i6kx3n6m 86 5 important important JJ cord-347946-i6kx3n6m 86 6 to to TO cord-347946-i6kx3n6m 86 7 note note VB cord-347946-i6kx3n6m 86 8 that that IN cord-347946-i6kx3n6m 86 9 a a DT cord-347946-i6kx3n6m 86 10 number number NN cord-347946-i6kx3n6m 86 11 of of IN cord-347946-i6kx3n6m 86 12 these these DT cord-347946-i6kx3n6m 86 13 factors factor NNS cord-347946-i6kx3n6m 86 14 - - , cord-347946-i6kx3n6m 86 15 such such JJ cord-347946-i6kx3n6m 86 16 as as IN cord-347946-i6kx3n6m 86 17 obesity obesity NN cord-347946-i6kx3n6m 86 18 , , , cord-347946-i6kx3n6m 86 19 sedentary sedentary JJ cord-347946-i6kx3n6m 86 20 lifestyle lifestyle NN cord-347946-i6kx3n6m 86 21 and and CC cord-347946-i6kx3n6m 86 22 processed process VBN cord-347946-i6kx3n6m 86 23 foods food NNS cord-347946-i6kx3n6m 86 24 - - , cord-347946-i6kx3n6m 86 25 are be VBP cord-347946-i6kx3n6m 86 26 artifacts artifact NNS cord-347946-i6kx3n6m 86 27 of of IN cord-347946-i6kx3n6m 86 28 modern modern JJ cord-347946-i6kx3n6m 86 29 lifestyles lifestyle NNS cord-347946-i6kx3n6m 86 30 , , , cord-347946-i6kx3n6m 86 31 and and CC cord-347946-i6kx3n6m 86 32 therefore therefore RB cord-347946-i6kx3n6m 86 33 are be VBP cord-347946-i6kx3n6m 86 34 unlikely unlikely JJ cord-347946-i6kx3n6m 86 35 to to TO cord-347946-i6kx3n6m 86 36 have have VB cord-347946-i6kx3n6m 86 37 evolved evolve VBN cord-347946-i6kx3n6m 86 38 to to TO cord-347946-i6kx3n6m 86 39 activate activate VB cord-347946-i6kx3n6m 86 40 depression depression NN cord-347946-i6kx3n6m 86 41 as as IN cord-347946-i6kx3n6m 86 42 a a DT cord-347946-i6kx3n6m 86 43 result result NN cord-347946-i6kx3n6m 86 44 of of IN cord-347946-i6kx3n6m 86 45 being be VBG cord-347946-i6kx3n6m 86 46 ' ' `` cord-347946-i6kx3n6m 86 47 early early JJ cord-347946-i6kx3n6m 86 48 warning warning NN cord-347946-i6kx3n6m 86 49 signs sign NNS cord-347946-i6kx3n6m 86 50 ' ' '' cord-347946-i6kx3n6m 86 51 of of IN cord-347946-i6kx3n6m 86 52 impending impend VBG cord-347946-i6kx3n6m 86 53 infectious infectious JJ cord-347946-i6kx3n6m 86 54 morbidity morbidity NN cord-347946-i6kx3n6m 86 55 / / SYM cord-347946-i6kx3n6m 86 56 mortality mortality NN cord-347946-i6kx3n6m 86 57 in in IN cord-347946-i6kx3n6m 86 58 the the DT cord-347946-i6kx3n6m 86 59 environment environment NN cord-347946-i6kx3n6m 86 60 of of IN cord-347946-i6kx3n6m 86 61 evolutionary evolutionary JJ cord-347946-i6kx3n6m 86 62 adaptiveness adaptiveness NN cord-347946-i6kx3n6m 86 63 ( ( -LRB- cord-347946-i6kx3n6m 86 64 EEA EEA NNP cord-347946-i6kx3n6m 86 65 ) ) -RRB- cord-347946-i6kx3n6m 86 66 , , , cord-347946-i6kx3n6m 86 67 as as IN cord-347946-i6kx3n6m 86 68 would would MD cord-347946-i6kx3n6m 86 69 be be VB cord-347946-i6kx3n6m 86 70 predicted predict VBN cord-347946-i6kx3n6m 86 71 by by IN cord-347946-i6kx3n6m 86 72 PATHOS PATHOS NNP cord-347946-i6kx3n6m 86 73 - - HYPH cord-347946-i6kx3n6m 86 74 D. D. NNP cord-347946-i6kx3n6m 87 1 However however RB cord-347946-i6kx3n6m 87 2 , , , cord-347946-i6kx3n6m 87 3 at at RB cord-347946-i6kx3n6m 87 4 least least JJS cord-347946-i6kx3n6m 87 5 two two CD cord-347946-i6kx3n6m 87 6 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 87 7 risk risk NN cord-347946-i6kx3n6m 87 8 factors factor NNS cord-347946-i6kx3n6m 87 9 for for IN cord-347946-i6kx3n6m 87 10 MDD MDD NNP cord-347946-i6kx3n6m 87 11 - - HYPH cord-347946-i6kx3n6m 87 12 medical medical JJ cord-347946-i6kx3n6m 87 13 illness illness NN cord-347946-i6kx3n6m 87 14 and and CC cord-347946-i6kx3n6m 87 15 psychosocial psychosocial JJ cord-347946-i6kx3n6m 87 16 stress stress NN cord-347946-i6kx3n6m 87 17 - - : cord-347946-i6kx3n6m 87 18 are be VBP cord-347946-i6kx3n6m 87 19 certainly certainly RB cord-347946-i6kx3n6m 87 20 ancient ancient JJ cord-347946-i6kx3n6m 87 21 and and CC cord-347946-i6kx3n6m 87 22 may may MD cord-347946-i6kx3n6m 87 23 well well RB cord-347946-i6kx3n6m 87 24 have have VB cord-347946-i6kx3n6m 87 25 evolved evolve VBN cord-347946-i6kx3n6m 87 26 an an DT cord-347946-i6kx3n6m 87 27 association association NN cord-347946-i6kx3n6m 87 28 with with IN cord-347946-i6kx3n6m 87 29 depression depression NN cord-347946-i6kx3n6m 87 30 as as IN cord-347946-i6kx3n6m 87 31 a a DT cord-347946-i6kx3n6m 87 32 result result NN cord-347946-i6kx3n6m 87 33 of of IN cord-347946-i6kx3n6m 87 34 inducing induce VBG cord-347946-i6kx3n6m 87 35 immune immune JJ cord-347946-i6kx3n6m 87 36 changes change NNS cord-347946-i6kx3n6m 87 37 that that WDT cord-347946-i6kx3n6m 87 38 enhanced enhance VBD cord-347946-i6kx3n6m 87 39 survival survival NN cord-347946-i6kx3n6m 87 40 in in IN cord-347946-i6kx3n6m 87 41 the the DT cord-347946-i6kx3n6m 87 42 EEA EEA NNP cord-347946-i6kx3n6m 87 43 . . . cord-347946-i6kx3n6m 88 1 PATHOS pathos NN cord-347946-i6kx3n6m 88 2 - - HYPH cord-347946-i6kx3n6m 88 3 D D NNP cord-347946-i6kx3n6m 88 4 proposes propose VBZ cord-347946-i6kx3n6m 88 5 that that IN cord-347946-i6kx3n6m 88 6 depression depression NN cord-347946-i6kx3n6m 88 7 evolved evolve VBD cord-347946-i6kx3n6m 88 8 out out IN cord-347946-i6kx3n6m 88 9 of of IN cord-347946-i6kx3n6m 88 10 sickness sickness NN cord-347946-i6kx3n6m 88 11 , , , cord-347946-i6kx3n6m 88 12 so so RB cord-347946-i6kx3n6m 89 1 it -PRON- PRP cord-347946-i6kx3n6m 89 2 is be VBZ cord-347946-i6kx3n6m 89 3 no no DT cord-347946-i6kx3n6m 89 4 surprise surprise NN cord-347946-i6kx3n6m 89 5 that that IN cord-347946-i6kx3n6m 89 6 robust robust JJ cord-347946-i6kx3n6m 89 7 associations association NNS cord-347946-i6kx3n6m 89 8 have have VBP cord-347946-i6kx3n6m 89 9 been be VBN cord-347946-i6kx3n6m 89 10 seen see VBN cord-347946-i6kx3n6m 89 11 between between IN cord-347946-i6kx3n6m 89 12 medical medical JJ cord-347946-i6kx3n6m 89 13 illness illness NN cord-347946-i6kx3n6m 89 14 and and CC cord-347946-i6kx3n6m 89 15 increased increase VBN cord-347946-i6kx3n6m 89 16 rates rate NNS cord-347946-i6kx3n6m 89 17 of of IN cord-347946-i6kx3n6m 89 18 depression depression NN cord-347946-i6kx3n6m 89 19 in in IN cord-347946-i6kx3n6m 89 20 all all DT cord-347946-i6kx3n6m 89 21 cultures culture NNS cord-347946-i6kx3n6m 89 22 examined examine VBN cord-347946-i6kx3n6m 89 23 ( ( -LRB- cord-347946-i6kx3n6m 89 24 Moussavi Moussavi NNP cord-347946-i6kx3n6m 89 25 et et NNP cord-347946-i6kx3n6m 89 26 al al NNP cord-347946-i6kx3n6m 89 27 , , , cord-347946-i6kx3n6m 89 28 2007 2007 CD cord-347946-i6kx3n6m 89 29 ) ) -RRB- cord-347946-i6kx3n6m 89 30 . . . cord-347946-i6kx3n6m 90 1 Because because IN cord-347946-i6kx3n6m 90 2 cytokines cytokine NNS cord-347946-i6kx3n6m 90 3 are be VBP cord-347946-i6kx3n6m 90 4 primary primary JJ cord-347946-i6kx3n6m 90 5 drivers driver NNS cord-347946-i6kx3n6m 90 6 of of IN cord-347946-i6kx3n6m 90 7 sickness sickness NN cord-347946-i6kx3n6m 90 8 , , , cord-347946-i6kx3n6m 90 9 it -PRON- PRP cord-347946-i6kx3n6m 90 10 is be VBZ cord-347946-i6kx3n6m 90 11 also also RB cord-347946-i6kx3n6m 90 12 no no DT cord-347946-i6kx3n6m 90 13 surprise surprise NN cord-347946-i6kx3n6m 90 14 that that IN cord-347946-i6kx3n6m 90 15 medical medical JJ cord-347946-i6kx3n6m 90 16 illnesses illness NNS cord-347946-i6kx3n6m 90 17 are be VBP cord-347946-i6kx3n6m 90 18 typically typically RB cord-347946-i6kx3n6m 90 19 characterized characterize VBN cord-347946-i6kx3n6m 90 20 by by IN cord-347946-i6kx3n6m 90 21 increased increase VBN cord-347946-i6kx3n6m 90 22 inflammation inflammation NN cord-347946-i6kx3n6m 90 23 , , , cord-347946-i6kx3n6m 90 24 nor nor CC cord-347946-i6kx3n6m 90 25 that that IN cord-347946-i6kx3n6m 90 26 increased increase VBN cord-347946-i6kx3n6m 90 27 levels level NNS cord-347946-i6kx3n6m 90 28 of of IN cord-347946-i6kx3n6m 90 29 inflammatory inflammatory JJ cord-347946-i6kx3n6m 90 30 cytokines cytokine NNS cord-347946-i6kx3n6m 90 31 in in IN cord-347946-i6kx3n6m 90 32 medically medically RB cord-347946-i6kx3n6m 90 33 ill ill JJ cord-347946-i6kx3n6m 90 34 patients patient NNS cord-347946-i6kx3n6m 90 35 are be VBP cord-347946-i6kx3n6m 90 36 associated associate VBN cord-347946-i6kx3n6m 90 37 with with IN cord-347946-i6kx3n6m 90 38 an an DT cord-347946-i6kx3n6m 90 39 increased increase VBN cord-347946-i6kx3n6m 90 40 risk risk NN cord-347946-i6kx3n6m 90 41 for for IN cord-347946-i6kx3n6m 90 42 depression depression NN cord-347946-i6kx3n6m 90 43 ( ( -LRB- cord-347946-i6kx3n6m 90 44 Musselman Musselman NNP cord-347946-i6kx3n6m 90 45 , , , cord-347946-i6kx3n6m 90 46 2001 2001 CD cord-347946-i6kx3n6m 90 47 ) ) -RRB- cord-347946-i6kx3n6m 90 48 . . . cord-347946-i6kx3n6m 91 1 On on IN cord-347946-i6kx3n6m 91 2 the the DT cord-347946-i6kx3n6m 91 3 other other JJ cord-347946-i6kx3n6m 91 4 hand hand NN cord-347946-i6kx3n6m 91 5 , , , cord-347946-i6kx3n6m 91 6 it -PRON- PRP cord-347946-i6kx3n6m 91 7 is be VBZ cord-347946-i6kx3n6m 91 8 not not RB cord-347946-i6kx3n6m 91 9 immediately immediately RB cord-347946-i6kx3n6m 91 10 apparent apparent JJ cord-347946-i6kx3n6m 91 11 why why WRB cord-347946-i6kx3n6m 91 12 psychosocial psychosocial JJ cord-347946-i6kx3n6m 91 13 stressors stressor NNS cord-347946-i6kx3n6m 91 14 should should MD cord-347946-i6kx3n6m 91 15 so so RB cord-347946-i6kx3n6m 91 16 reliably reliably RB cord-347946-i6kx3n6m 91 17 activate activate VB cord-347946-i6kx3n6m 91 18 inflammatory inflammatory JJ cord-347946-i6kx3n6m 91 19 pathways pathway NNS cord-347946-i6kx3n6m 91 20 in in IN cord-347946-i6kx3n6m 91 21 animals animal NNS cord-347946-i6kx3n6m 91 22 and and CC cord-347946-i6kx3n6m 91 23 humans human NNS cord-347946-i6kx3n6m 91 24 when when WRB cord-347946-i6kx3n6m 91 25 these these DT cord-347946-i6kx3n6m 91 26 types type NNS cord-347946-i6kx3n6m 91 27 of of IN cord-347946-i6kx3n6m 91 28 adversities adversity NNS cord-347946-i6kx3n6m 91 29 are be VBP cord-347946-i6kx3n6m 91 30 not not RB cord-347946-i6kx3n6m 91 31 in in IN cord-347946-i6kx3n6m 91 32 and and CC cord-347946-i6kx3n6m 91 33 of of IN cord-347946-i6kx3n6m 91 34 themselves -PRON- PRP cord-347946-i6kx3n6m 91 35 associated associate VBN cord-347946-i6kx3n6m 91 36 with with IN cord-347946-i6kx3n6m 91 37 either either CC cord-347946-i6kx3n6m 91 38 an an DT cord-347946-i6kx3n6m 91 39 infectious infectious JJ cord-347946-i6kx3n6m 91 40 challenge challenge NN cord-347946-i6kx3n6m 91 41 or or CC cord-347946-i6kx3n6m 91 42 an an DT cord-347946-i6kx3n6m 91 43 immune immune JJ cord-347946-i6kx3n6m 91 44 stimulus stimulus NN cord-347946-i6kx3n6m 91 45 . . . cord-347946-i6kx3n6m 92 1 Indeed indeed RB cord-347946-i6kx3n6m 92 2 , , , cord-347946-i6kx3n6m 92 3 it -PRON- PRP cord-347946-i6kx3n6m 92 4 has have VBZ cord-347946-i6kx3n6m 92 5 become become VBN cord-347946-i6kx3n6m 92 6 so so RB cord-347946-i6kx3n6m 92 7 commonplace commonplace JJ cord-347946-i6kx3n6m 92 8 to to TO cord-347946-i6kx3n6m 92 9 say say VB cord-347946-i6kx3n6m 92 10 that that IN cord-347946-i6kx3n6m 92 11 stress stress NN cord-347946-i6kx3n6m 92 12 increases increase VBZ cord-347946-i6kx3n6m 92 13 inflammation inflammation NN cord-347946-i6kx3n6m 92 14 that that IN cord-347946-i6kx3n6m 92 15 it -PRON- PRP cord-347946-i6kx3n6m 92 16 is be VBZ cord-347946-i6kx3n6m 92 17 easy easy JJ cord-347946-i6kx3n6m 92 18 to to TO cord-347946-i6kx3n6m 92 19 lose lose VB cord-347946-i6kx3n6m 92 20 track track NN cord-347946-i6kx3n6m 92 21 of of IN cord-347946-i6kx3n6m 92 22 what what WP cord-347946-i6kx3n6m 92 23 a a DT cord-347946-i6kx3n6m 92 24 remarkable remarkable JJ cord-347946-i6kx3n6m 92 25 thing thing NN cord-347946-i6kx3n6m 92 26 this this DT cord-347946-i6kx3n6m 92 27 is be VBZ cord-347946-i6kx3n6m 92 28 . . . cord-347946-i6kx3n6m 93 1 Consider consider VB cord-347946-i6kx3n6m 93 2 the the DT cord-347946-i6kx3n6m 93 3 Trier Trier NNP cord-347946-i6kx3n6m 93 4 Social Social NNP cord-347946-i6kx3n6m 93 5 Stress Stress NNP cord-347946-i6kx3n6m 93 6 Test Test NNP cord-347946-i6kx3n6m 93 7 ( ( -LRB- cord-347946-i6kx3n6m 93 8 TSST TSST NNP cord-347946-i6kx3n6m 93 9 ) ) -RRB- cord-347946-i6kx3n6m 93 10 in in IN cord-347946-i6kx3n6m 93 11 which which WDT cord-347946-i6kx3n6m 93 12 study study NN cord-347946-i6kx3n6m 93 13 participants participant NNS cord-347946-i6kx3n6m 93 14 are be VBP cord-347946-i6kx3n6m 93 15 charged charge VBN cord-347946-i6kx3n6m 93 16 with with IN cord-347946-i6kx3n6m 93 17 giving give VBG cord-347946-i6kx3n6m 93 18 a a DT cord-347946-i6kx3n6m 93 19 personally personally RB cord-347946-i6kx3n6m 93 20 meaningful meaningful JJ cord-347946-i6kx3n6m 93 21 speech speech NN cord-347946-i6kx3n6m 93 22 and and CC cord-347946-i6kx3n6m 93 23 doing do VBG cord-347946-i6kx3n6m 93 24 mental mental JJ cord-347946-i6kx3n6m 93 25 arithmetic arithmetic NNS cord-347946-i6kx3n6m 93 26 in in IN cord-347946-i6kx3n6m 93 27 the the DT cord-347946-i6kx3n6m 93 28 presence presence NN cord-347946-i6kx3n6m 93 29 of of IN cord-347946-i6kx3n6m 93 30 a a DT cord-347946-i6kx3n6m 93 31 judgmental judgmental JJ cord-347946-i6kx3n6m 93 32 panel panel NN cord-347946-i6kx3n6m 93 33 . . . cord-347946-i6kx3n6m 94 1 Predictably predictably RB cord-347946-i6kx3n6m 94 2 , , , cord-347946-i6kx3n6m 94 3 the the DT cord-347946-i6kx3n6m 94 4 threatened threaten VBN cord-347946-i6kx3n6m 94 5 subject subject JJ cord-347946-i6kx3n6m 94 6 experiences experience NNS cord-347946-i6kx3n6m 94 7 a a DT cord-347946-i6kx3n6m 94 8 classic classic JJ cord-347946-i6kx3n6m 94 9 fight fight NN cord-347946-i6kx3n6m 94 10 or or CC cord-347946-i6kx3n6m 94 11 flight flight NN cord-347946-i6kx3n6m 94 12 response response NN cord-347946-i6kx3n6m 94 13 characterized characterize VBN cord-347946-i6kx3n6m 94 14 by by IN cord-347946-i6kx3n6m 94 15 an an DT cord-347946-i6kx3n6m 94 16 increased increase VBN cord-347946-i6kx3n6m 94 17 heart heart NN cord-347946-i6kx3n6m 94 18 rate rate NN cord-347946-i6kx3n6m 94 19 and and CC cord-347946-i6kx3n6m 94 20 blood blood NN cord-347946-i6kx3n6m 94 21 pressure pressure NN cord-347946-i6kx3n6m 94 22 and and CC cord-347946-i6kx3n6m 94 23 an an DT cord-347946-i6kx3n6m 94 24 increased increase VBN cord-347946-i6kx3n6m 94 25 release release NN cord-347946-i6kx3n6m 94 26 of of IN cord-347946-i6kx3n6m 94 27 cortisol cortisol NN cord-347946-i6kx3n6m 94 28 and and CC cord-347946-i6kx3n6m 94 29 catecholamines catecholamine NNS cord-347946-i6kx3n6m 94 30 . . . cord-347946-i6kx3n6m 95 1 However however RB cord-347946-i6kx3n6m 95 2 , , , cord-347946-i6kx3n6m 95 3 the the DT cord-347946-i6kx3n6m 95 4 TSST TSST NNP cord-347946-i6kx3n6m 95 5 also also RB cord-347946-i6kx3n6m 95 6 activates activate VBZ cord-347946-i6kx3n6m 95 7 key key JJ cord-347946-i6kx3n6m 95 8 intracellular intracellular JJ cord-347946-i6kx3n6m 95 9 inflammatory inflammatory JJ cord-347946-i6kx3n6m 95 10 transcription transcription NN cord-347946-i6kx3n6m 95 11 pathways pathway NNS cord-347946-i6kx3n6m 95 12 ( ( -LRB- cord-347946-i6kx3n6m 95 13 eg eg IN cord-347946-i6kx3n6m 95 14 , , , cord-347946-i6kx3n6m 95 15 nuclear nuclear JJ cord-347946-i6kx3n6m 95 16 factor factor NN cord-347946-i6kx3n6m 95 17 - - HYPH cord-347946-i6kx3n6m 95 18 kappa kappa NN cord-347946-i6kx3n6m 95 19 β β NN cord-347946-i6kx3n6m 95 20 ( ( -LRB- cord-347946-i6kx3n6m 95 21 NF NF NNP cord-347946-i6kx3n6m 95 22 - - HYPH cord-347946-i6kx3n6m 95 23 κB κB NNP cord-347946-i6kx3n6m 95 24 ) ) -RRB- cord-347946-i6kx3n6m 95 25 ) ) -RRB- cord-347946-i6kx3n6m 95 26 within within IN cord-347946-i6kx3n6m 95 27 peripheral peripheral JJ cord-347946-i6kx3n6m 95 28 blood blood NN cord-347946-i6kx3n6m 95 29 mononuclear mononuclear NN cord-347946-i6kx3n6m 95 30 cells cell NNS cord-347946-i6kx3n6m 95 31 and and CC cord-347946-i6kx3n6m 95 32 dramatically dramatically RB cord-347946-i6kx3n6m 95 33 increases increase VBZ cord-347946-i6kx3n6m 95 34 circulating circulate VBG cord-347946-i6kx3n6m 95 35 levels level NNS cord-347946-i6kx3n6m 95 36 of of IN cord-347946-i6kx3n6m 95 37 inflammatory inflammatory JJ cord-347946-i6kx3n6m 95 38 cytokines cytokine NNS cord-347946-i6kx3n6m 95 39 , , , cord-347946-i6kx3n6m 95 40 such such JJ cord-347946-i6kx3n6m 95 41 as as IN cord-347946-i6kx3n6m 95 42 interleukin interleukin NN cord-347946-i6kx3n6m 95 43 ( ( -LRB- cord-347946-i6kx3n6m 95 44 IL)-6 il)-6 NN cord-347946-i6kx3n6m 96 1 ( ( -LRB- cord-347946-i6kx3n6m 96 2 Bierhaus Bierhaus NNP cord-347946-i6kx3n6m 96 3 et et NNP cord-347946-i6kx3n6m 96 4 al al NNP cord-347946-i6kx3n6m 96 5 , , , cord-347946-i6kx3n6m 96 6 2003 2003 CD cord-347946-i6kx3n6m 96 7 ; ; : cord-347946-i6kx3n6m 96 8 Pace Pace NNP cord-347946-i6kx3n6m 96 9 et et NNP cord-347946-i6kx3n6m 96 10 al al NNP cord-347946-i6kx3n6m 96 11 , , , cord-347946-i6kx3n6m 96 12 2006a 2006a CD cord-347946-i6kx3n6m 96 13 ; ; : cord-347946-i6kx3n6m 96 14 Carpenter Carpenter NNP cord-347946-i6kx3n6m 96 15 et et NNP cord-347946-i6kx3n6m 96 16 al al NNP cord-347946-i6kx3n6m 96 17 , , , cord-347946-i6kx3n6m 96 18 2010 2010 CD cord-347946-i6kx3n6m 96 19 ) ) -RRB- cord-347946-i6kx3n6m 96 20 . . . cord-347946-i6kx3n6m 97 1 Moreover moreover RB cord-347946-i6kx3n6m 97 2 , , , cord-347946-i6kx3n6m 97 3 individuals individual NNS cord-347946-i6kx3n6m 97 4 with with IN cord-347946-i6kx3n6m 97 5 known know VBN cord-347946-i6kx3n6m 97 6 risk risk NN cord-347946-i6kx3n6m 97 7 factors factor NNS cord-347946-i6kx3n6m 97 8 for for IN cord-347946-i6kx3n6m 97 9 developing develop VBG cord-347946-i6kx3n6m 97 10 depression depression NN cord-347946-i6kx3n6m 97 11 ( ( -LRB- cord-347946-i6kx3n6m 97 12 eg eg IN cord-347946-i6kx3n6m 97 13 , , , cord-347946-i6kx3n6m 97 14 early early JJ cord-347946-i6kx3n6m 97 15 - - HYPH cord-347946-i6kx3n6m 97 16 life life NN cord-347946-i6kx3n6m 97 17 adversity adversity NN cord-347946-i6kx3n6m 97 18 ) ) -RRB- cord-347946-i6kx3n6m 97 19 show show VBP cord-347946-i6kx3n6m 97 20 larger large JJR cord-347946-i6kx3n6m 97 21 inflammatory inflammatory JJ cord-347946-i6kx3n6m 97 22 responses response NNS cord-347946-i6kx3n6m 97 23 to to IN cord-347946-i6kx3n6m 97 24 laboratory laboratory NN cord-347946-i6kx3n6m 97 25 psychosocial psychosocial JJ cord-347946-i6kx3n6m 97 26 stressors stressor NNS cord-347946-i6kx3n6m 97 27 than than IN cord-347946-i6kx3n6m 97 28 do do VB cord-347946-i6kx3n6m 97 29 others other NNS cord-347946-i6kx3n6m 97 30 ( ( -LRB- cord-347946-i6kx3n6m 97 31 Pace pace VB cord-347946-i6kx3n6m 97 32 et et NNP cord-347946-i6kx3n6m 97 33 al al NNP cord-347946-i6kx3n6m 97 34 , , , cord-347946-i6kx3n6m 97 35 2006a 2006a CD cord-347946-i6kx3n6m 97 36 ; ; : cord-347946-i6kx3n6m 97 37 Carpenter Carpenter NNP cord-347946-i6kx3n6m 97 38 et et NNP cord-347946-i6kx3n6m 97 39 al al NNP cord-347946-i6kx3n6m 97 40 , , , cord-347946-i6kx3n6m 97 41 2010 2010 CD cord-347946-i6kx3n6m 97 42 ) ) -RRB- cord-347946-i6kx3n6m 97 43 , , , cord-347946-i6kx3n6m 97 44 and and CC cord-347946-i6kx3n6m 97 45 the the DT cord-347946-i6kx3n6m 97 46 larger large JJR cord-347946-i6kx3n6m 97 47 the the DT cord-347946-i6kx3n6m 97 48 inflammatory inflammatory JJ cord-347946-i6kx3n6m 97 49 response response NN cord-347946-i6kx3n6m 97 50 to to IN cord-347946-i6kx3n6m 97 51 the the DT cord-347946-i6kx3n6m 97 52 stressor stressor NN cord-347946-i6kx3n6m 97 53 , , , cord-347946-i6kx3n6m 97 54 the the DT cord-347946-i6kx3n6m 97 55 more more RBR cord-347946-i6kx3n6m 97 56 likely likely RB cord-347946-i6kx3n6m 97 57 the the DT cord-347946-i6kx3n6m 97 58 subject subject NN cord-347946-i6kx3n6m 97 59 is be VBZ cord-347946-i6kx3n6m 97 60 to to TO cord-347946-i6kx3n6m 97 61 develop develop VB cord-347946-i6kx3n6m 97 62 depression depression NN cord-347946-i6kx3n6m 97 63 over over IN cord-347946-i6kx3n6m 97 64 the the DT cord-347946-i6kx3n6m 97 65 ensuing ensue VBG cord-347946-i6kx3n6m 97 66 months month NNS cord-347946-i6kx3n6m 98 1 ( ( -LRB- cord-347946-i6kx3n6m 98 2 Aschbacher Aschbacher NNP cord-347946-i6kx3n6m 98 3 et et NNP cord-347946-i6kx3n6m 98 4 al al NNP cord-347946-i6kx3n6m 98 5 , , , cord-347946-i6kx3n6m 98 6 2012 2012 CD cord-347946-i6kx3n6m 98 7 ) ) -RRB- cord-347946-i6kx3n6m 98 8 . . . cord-347946-i6kx3n6m 99 1 In in IN cord-347946-i6kx3n6m 99 2 essence essence NN cord-347946-i6kx3n6m 99 3 , , , cord-347946-i6kx3n6m 99 4 the the DT cord-347946-i6kx3n6m 99 5 body body NN cord-347946-i6kx3n6m 99 6 mounts mount VBZ cord-347946-i6kx3n6m 99 7 an an DT cord-347946-i6kx3n6m 99 8 immune immune JJ cord-347946-i6kx3n6m 99 9 response response NN cord-347946-i6kx3n6m 99 10 , , , cord-347946-i6kx3n6m 99 11 not not RB cord-347946-i6kx3n6m 99 12 against against IN cord-347946-i6kx3n6m 99 13 a a DT cord-347946-i6kx3n6m 99 14 pathogen pathogen NN cord-347946-i6kx3n6m 99 15 , , , cord-347946-i6kx3n6m 99 16 but but CC cord-347946-i6kx3n6m 99 17 against against IN cord-347946-i6kx3n6m 99 18 a a DT cord-347946-i6kx3n6m 99 19 threat threat NN cord-347946-i6kx3n6m 99 20 to to IN cord-347946-i6kx3n6m 99 21 the the DT cord-347946-i6kx3n6m 99 22 subject subject NN cord-347946-i6kx3n6m 99 23 's 's POS cord-347946-i6kx3n6m 99 24 self self NN cord-347946-i6kx3n6m 99 25 - - HYPH cord-347946-i6kx3n6m 99 26 esteem esteem NN cord-347946-i6kx3n6m 99 27 . . . cord-347946-i6kx3n6m 100 1 Theories theory NNS cord-347946-i6kx3n6m 100 2 that that WDT cord-347946-i6kx3n6m 100 3 view view VBP cord-347946-i6kx3n6m 100 4 depression depression NN cord-347946-i6kx3n6m 100 5 as as IN cord-347946-i6kx3n6m 100 6 having have VBG cord-347946-i6kx3n6m 100 7 evolved evolve VBN cord-347946-i6kx3n6m 100 8 to to TO cord-347946-i6kx3n6m 100 9 serve serve VB cord-347946-i6kx3n6m 100 10 adaptive adaptive JJ cord-347946-i6kx3n6m 100 11 social social JJ cord-347946-i6kx3n6m 100 12 purposes purpose NNS cord-347946-i6kx3n6m 100 13 do do VBP cord-347946-i6kx3n6m 100 14 not not RB cord-347946-i6kx3n6m 100 15 yield yield VB cord-347946-i6kx3n6m 100 16 easy easy JJ cord-347946-i6kx3n6m 100 17 explanations explanation NNS cord-347946-i6kx3n6m 100 18 for for IN cord-347946-i6kx3n6m 100 19 why why WRB cord-347946-i6kx3n6m 100 20 non non JJ cord-347946-i6kx3n6m 100 21 - - JJ cord-347946-i6kx3n6m 100 22 infectious infectious JJ cord-347946-i6kx3n6m 100 23 stressors stressor NNS cord-347946-i6kx3n6m 100 24 should should MD cord-347946-i6kx3n6m 100 25 activate activate VB cord-347946-i6kx3n6m 100 26 peripheral peripheral JJ cord-347946-i6kx3n6m 100 27 inflammatory inflammatory JJ cord-347946-i6kx3n6m 100 28 pathways pathway NNS cord-347946-i6kx3n6m 100 29 . . . cord-347946-i6kx3n6m 101 1 On on IN cord-347946-i6kx3n6m 101 2 the the DT cord-347946-i6kx3n6m 101 3 other other JJ cord-347946-i6kx3n6m 101 4 hand hand NN cord-347946-i6kx3n6m 101 5 , , , cord-347946-i6kx3n6m 101 6 PATHOS pathos NN cord-347946-i6kx3n6m 101 7 - - HYPH cord-347946-i6kx3n6m 101 8 D D NNP cord-347946-i6kx3n6m 101 9 suggests suggest VBZ cord-347946-i6kx3n6m 101 10 a a DT cord-347946-i6kx3n6m 101 11 straightforward straightforward JJ cord-347946-i6kx3n6m 101 12 and and CC cord-347946-i6kx3n6m 101 13 parsimonious parsimonious JJ cord-347946-i6kx3n6m 101 14 explanation explanation NN cord-347946-i6kx3n6m 101 15 . . . cord-347946-i6kx3n6m 102 1 Because because IN cord-347946-i6kx3n6m 102 2 the the DT cord-347946-i6kx3n6m 102 3 vast vast JJ cord-347946-i6kx3n6m 102 4 majority majority NN cord-347946-i6kx3n6m 102 5 of of IN cord-347946-i6kx3n6m 102 6 stressors stressor NNS cord-347946-i6kx3n6m 102 7 in in IN cord-347946-i6kx3n6m 102 8 mammals mammal NNS cord-347946-i6kx3n6m 102 9 over over IN cord-347946-i6kx3n6m 102 10 evolutionary evolutionary JJ cord-347946-i6kx3n6m 102 11 time time NN cord-347946-i6kx3n6m 102 12 boiled boil VBD cord-347946-i6kx3n6m 102 13 down down RP cord-347946-i6kx3n6m 102 14 to to IN cord-347946-i6kx3n6m 102 15 risks risk NNS cord-347946-i6kx3n6m 102 16 inherent inherent JJ cord-347946-i6kx3n6m 102 17 in in IN cord-347946-i6kx3n6m 102 18 hunting hunting NN cord-347946-i6kx3n6m 102 19 , , , cord-347946-i6kx3n6m 102 20 being be VBG cord-347946-i6kx3n6m 102 21 hunted hunt VBN cord-347946-i6kx3n6m 102 22 or or CC cord-347946-i6kx3n6m 102 23 fighting fight VBG cord-347946-i6kx3n6m 102 24 conspecifics conspecific NNS cord-347946-i6kx3n6m 102 25 in in IN cord-347946-i6kx3n6m 102 26 dominance dominance NN cord-347946-i6kx3n6m 102 27 hierarchies hierarchy NNS cord-347946-i6kx3n6m 102 28 for for IN cord-347946-i6kx3n6m 102 29 reproductive reproductive JJ cord-347946-i6kx3n6m 102 30 access access NN cord-347946-i6kx3n6m 102 31 / / SYM cord-347946-i6kx3n6m 102 32 status status NN cord-347946-i6kx3n6m 102 33 , , , cord-347946-i6kx3n6m 102 34 it -PRON- PRP cord-347946-i6kx3n6m 102 35 is be VBZ cord-347946-i6kx3n6m 102 36 not not RB cord-347946-i6kx3n6m 102 37 surprising surprising JJ cord-347946-i6kx3n6m 102 38 that that IN cord-347946-i6kx3n6m 102 39 these these DT cord-347946-i6kx3n6m 102 40 states state NNS cord-347946-i6kx3n6m 102 41 are be VBP cord-347946-i6kx3n6m 102 42 also also RB cord-347946-i6kx3n6m 102 43 circumstances circumstance NNS cord-347946-i6kx3n6m 102 44 in in IN cord-347946-i6kx3n6m 102 45 which which WDT cord-347946-i6kx3n6m 102 46 the the DT cord-347946-i6kx3n6m 102 47 risk risk NN cord-347946-i6kx3n6m 102 48 of of IN cord-347946-i6kx3n6m 102 49 pathogen pathogen NN cord-347946-i6kx3n6m 102 50 invasion invasion NN cord-347946-i6kx3n6m 102 51 - - , cord-347946-i6kx3n6m 102 52 and and CC cord-347946-i6kx3n6m 102 53 subsequent subsequent JJ cord-347946-i6kx3n6m 102 54 death death NN cord-347946-i6kx3n6m 102 55 from from IN cord-347946-i6kx3n6m 102 56 infectionwas infectionwas NNP cord-347946-i6kx3n6m 102 57 greatly greatly RB cord-347946-i6kx3n6m 102 58 increased increase VBD cord-347946-i6kx3n6m 102 59 as as IN cord-347946-i6kx3n6m 102 60 a a DT cord-347946-i6kx3n6m 102 61 result result NN cord-347946-i6kx3n6m 102 62 of of IN cord-347946-i6kx3n6m 102 63 traumatic traumatic JJ cord-347946-i6kx3n6m 102 64 opening opening NN cord-347946-i6kx3n6m 102 65 of of IN cord-347946-i6kx3n6m 102 66 the the DT cord-347946-i6kx3n6m 102 67 protective protective JJ cord-347946-i6kx3n6m 102 68 skin skin NN cord-347946-i6kx3n6m 102 69 barrier barrier NN cord-347946-i6kx3n6m 102 70 from from IN cord-347946-i6kx3n6m 102 71 wounding wound VBG cord-347946-i6kx3n6m 102 72 ( ( -LRB- cord-347946-i6kx3n6m 102 73 DiPietro DiPietro NNP cord-347946-i6kx3n6m 102 74 , , , cord-347946-i6kx3n6m 102 75 1995 1995 CD cord-347946-i6kx3n6m 102 76 ) ) -RRB- cord-347946-i6kx3n6m 102 77 . . . cord-347946-i6kx3n6m 103 1 Such such JJ cord-347946-i6kx3n6m 103 2 wounding wounding NN cord-347946-i6kx3n6m 103 3 is be VBZ cord-347946-i6kx3n6m 103 4 common common JJ cord-347946-i6kx3n6m 103 5 in in IN cord-347946-i6kx3n6m 103 6 social social JJ cord-347946-i6kx3n6m 103 7 species specie NNS cord-347946-i6kx3n6m 103 8 and and CC cord-347946-i6kx3n6m 103 9 was be VBD cord-347946-i6kx3n6m 103 10 a a DT cord-347946-i6kx3n6m 103 11 significant significant JJ cord-347946-i6kx3n6m 103 12 source source NN cord-347946-i6kx3n6m 103 13 of of IN cord-347946-i6kx3n6m 103 14 morbidity morbidity NN cord-347946-i6kx3n6m 103 15 and and CC cord-347946-i6kx3n6m 103 16 mortality mortality NN cord-347946-i6kx3n6m 103 17 among among IN cord-347946-i6kx3n6m 103 18 humans human NNS cord-347946-i6kx3n6m 103 19 in in IN cord-347946-i6kx3n6m 103 20 the the DT cord-347946-i6kx3n6m 103 21 ancestral ancestral JJ cord-347946-i6kx3n6m 103 22 environment environment NN cord-347946-i6kx3n6m 103 23 , , , cord-347946-i6kx3n6m 103 24 and and CC cord-347946-i6kx3n6m 103 25 indeed indeed RB cord-347946-i6kx3n6m 103 26 well well RB cord-347946-i6kx3n6m 103 27 into into IN cord-347946-i6kx3n6m 103 28 the the DT cord-347946-i6kx3n6m 103 29 historical historical JJ cord-347946-i6kx3n6m 103 30 period period NN cord-347946-i6kx3n6m 103 31 ( ( -LRB- cord-347946-i6kx3n6m 103 32 Ross Ross NNP cord-347946-i6kx3n6m 103 33 et et NNP cord-347946-i6kx3n6m 103 34 al al NNP cord-347946-i6kx3n6m 103 35 , , , cord-347946-i6kx3n6m 103 36 2009 2009 CD cord-347946-i6kx3n6m 103 37 ; ; : cord-347946-i6kx3n6m 103 38 Eshed Eshed NNP cord-347946-i6kx3n6m 103 39 et et FW cord-347946-i6kx3n6m 103 40 al al NNP cord-347946-i6kx3n6m 103 41 , , , cord-347946-i6kx3n6m 103 42 2010 2010 CD cord-347946-i6kx3n6m 103 43 ; ; : cord-347946-i6kx3n6m 103 44 Pinker Pinker NNP cord-347946-i6kx3n6m 103 45 , , , cord-347946-i6kx3n6m 103 46 2011 2011 CD cord-347946-i6kx3n6m 103 47 ) ) -RRB- cord-347946-i6kx3n6m 103 48 . . . cord-347946-i6kx3n6m 104 1 In in IN cord-347946-i6kx3n6m 104 2 ancestral ancestral JJ cord-347946-i6kx3n6m 104 3 environments environment NNS cord-347946-i6kx3n6m 104 4 , , , cord-347946-i6kx3n6m 104 5 the the DT cord-347946-i6kx3n6m 104 6 association association NN cord-347946-i6kx3n6m 104 7 between between IN cord-347946-i6kx3n6m 104 8 stress stress NN cord-347946-i6kx3n6m 104 9 perception perception NN cord-347946-i6kx3n6m 104 10 and and CC cord-347946-i6kx3n6m 104 11 risk risk NN cord-347946-i6kx3n6m 104 12 of of IN cord-347946-i6kx3n6m 104 13 subsequent subsequent JJ cord-347946-i6kx3n6m 104 14 wounding wounding NN cord-347946-i6kx3n6m 104 15 was be VBD cord-347946-i6kx3n6m 104 16 reliable reliable JJ cord-347946-i6kx3n6m 104 17 enough enough RB cord-347946-i6kx3n6m 104 18 that that DT cord-347946-i6kx3n6m 104 19 evolution evolution NN cord-347946-i6kx3n6m 104 20 , , , cord-347946-i6kx3n6m 104 21 operating operate VBG cord-347946-i6kx3n6m 104 22 by by IN cord-347946-i6kx3n6m 104 23 the the DT cord-347946-i6kx3n6m 104 24 so so RB cord-347946-i6kx3n6m 104 25 - - HYPH cord-347946-i6kx3n6m 104 26 called call VBN cord-347946-i6kx3n6m 104 27 ' ' '' cord-347946-i6kx3n6m 104 28 smoke smoke NN cord-347946-i6kx3n6m 104 29 detector detector NN cord-347946-i6kx3n6m 104 30 ' ' '' cord-347946-i6kx3n6m 104 31 principle principle NN cord-347946-i6kx3n6m 104 32 , , , cord-347946-i6kx3n6m 104 33 favored favor VBD cord-347946-i6kx3n6m 104 34 organisms organism NNS cord-347946-i6kx3n6m 104 35 that that WDT cord-347946-i6kx3n6m 104 36 prepotently prepotently RB cord-347946-i6kx3n6m 104 37 activated activate VBD cord-347946-i6kx3n6m 104 38 inflammatory inflammatory JJ cord-347946-i6kx3n6m 104 39 systems system NNS cord-347946-i6kx3n6m 104 40 in in IN cord-347946-i6kx3n6m 104 41 response response NN cord-347946-i6kx3n6m 104 42 to to IN cord-347946-i6kx3n6m 104 43 a a DT cord-347946-i6kx3n6m 104 44 wide wide JJ cord-347946-i6kx3n6m 104 45 array array NN cord-347946-i6kx3n6m 104 46 of of IN cord-347946-i6kx3n6m 104 47 environmental environmental JJ cord-347946-i6kx3n6m 104 48 threats threat NNS cord-347946-i6kx3n6m 104 49 and and CC cord-347946-i6kx3n6m 104 50 challenges challenge NNS cord-347946-i6kx3n6m 104 51 ( ( -LRB- cord-347946-i6kx3n6m 104 52 including include VBG cord-347946-i6kx3n6m 104 53 psychosocial psychosocial JJ cord-347946-i6kx3n6m 104 54 stressors stressor NNS cord-347946-i6kx3n6m 104 55 ) ) -RRB- cord-347946-i6kx3n6m 104 56 , , , cord-347946-i6kx3n6m 104 57 even even RB cord-347946-i6kx3n6m 104 58 if if IN cord-347946-i6kx3n6m 104 59 this this DT cord-347946-i6kx3n6m 104 60 activation activation NN cord-347946-i6kx3n6m 104 61 was be VBD cord-347946-i6kx3n6m 104 62 often often RB cord-347946-i6kx3n6m 104 63 a a DT cord-347946-i6kx3n6m 104 64 ' ' `` cord-347946-i6kx3n6m 104 65 false false JJ cord-347946-i6kx3n6m 104 66 alarm alarm NN cord-347946-i6kx3n6m 104 67 . . . cord-347946-i6kx3n6m 104 68 ' ' '' cord-347946-i6kx3n6m 105 1 As as IN cord-347946-i6kx3n6m 105 2 noted note VBN cord-347946-i6kx3n6m 105 3 by by IN cord-347946-i6kx3n6m 105 4 Dhabhar-'stress dhabhar-'stress JJ cord-347946-i6kx3n6m 105 5 perception perception NN cord-347946-i6kx3n6m 105 6 by by IN cord-347946-i6kx3n6m 105 7 the the DT cord-347946-i6kx3n6m 105 8 brain brain NN cord-347946-i6kx3n6m 105 9 may may MD cord-347946-i6kx3n6m 105 10 serve serve VB cord-347946-i6kx3n6m 105 11 as as IN cord-347946-i6kx3n6m 105 12 an an DT cord-347946-i6kx3n6m 105 13 early early JJ cord-347946-i6kx3n6m 105 14 warning warning NN cord-347946-i6kx3n6m 105 15 signal signal NN cord-347946-i6kx3n6m 105 16 to to TO cord-347946-i6kx3n6m 105 17 activate activate VB cord-347946-i6kx3n6m 105 18 the the DT cord-347946-i6kx3n6m 105 19 immune immune JJ cord-347946-i6kx3n6m 105 20 system system NN cord-347946-i6kx3n6m 105 21 in in IN cord-347946-i6kx3n6m 105 22 preparation preparation NN cord-347946-i6kx3n6m 105 23 for for IN cord-347946-i6kx3n6m 105 24 a a DT cord-347946-i6kx3n6m 105 25 markedly markedly RB cord-347946-i6kx3n6m 105 26 increased increase VBN cord-347946-i6kx3n6m 105 27 likelihood likelihood NN cord-347946-i6kx3n6m 105 28 of of IN cord-347946-i6kx3n6m 105 29 subsequent subsequent JJ cord-347946-i6kx3n6m 105 30 infection infection NN cord-347946-i6kx3n6m 105 31 ' ' '' cord-347946-i6kx3n6m 105 32 ( ( -LRB- cord-347946-i6kx3n6m 105 33 Dhabhar Dhabhar NNP cord-347946-i6kx3n6m 105 34 , , , cord-347946-i6kx3n6m 105 35 2009 2009 CD cord-347946-i6kx3n6m 105 36 ) ) -RRB- cord-347946-i6kx3n6m 105 37 . . . cord-347946-i6kx3n6m 106 1 And and CC cord-347946-i6kx3n6m 106 2 while while IN cord-347946-i6kx3n6m 106 3 chronic chronic JJ cord-347946-i6kx3n6m 106 4 stress stress NN cord-347946-i6kx3n6m 106 5 is be VBZ cord-347946-i6kx3n6m 106 6 best well RBS cord-347946-i6kx3n6m 106 7 known know VBN cord-347946-i6kx3n6m 106 8 to to TO cord-347946-i6kx3n6m 106 9 suppress suppress VB cord-347946-i6kx3n6m 106 10 certain certain JJ cord-347946-i6kx3n6m 106 11 aspects aspect NNS cord-347946-i6kx3n6m 106 12 of of IN cord-347946-i6kx3n6m 106 13 immune immune JJ cord-347946-i6kx3n6m 106 14 function function NN cord-347946-i6kx3n6m 106 15 ( ( -LRB- cord-347946-i6kx3n6m 106 16 ie ie FW cord-347946-i6kx3n6m 106 17 , , , cord-347946-i6kx3n6m 106 18 natural natural JJ cord-347946-i6kx3n6m 106 19 killer killer NN cord-347946-i6kx3n6m 106 20 cell cell NN cord-347946-i6kx3n6m 106 21 activity activity NN cord-347946-i6kx3n6m 106 22 , , , cord-347946-i6kx3n6m 106 23 circulating circulate VBG cord-347946-i6kx3n6m 106 24 T t NN cord-347946-i6kx3n6m 106 25 - - HYPH cord-347946-i6kx3n6m 106 26 cell cell NN cord-347946-i6kx3n6m 106 27 subsets subset NNS cord-347946-i6kx3n6m 106 28 ; ; : cord-347946-i6kx3n6m 106 29 Herbert Herbert NNP cord-347946-i6kx3n6m 106 30 and and CC cord-347946-i6kx3n6m 106 31 Cohen Cohen NNP cord-347946-i6kx3n6m 106 32 , , , cord-347946-i6kx3n6m 106 33 1993c 1993c CD cord-347946-i6kx3n6m 106 34 ) ) -RRB- cord-347946-i6kx3n6m 106 35 , , , cord-347946-i6kx3n6m 106 36 the the DT cord-347946-i6kx3n6m 106 37 types type NNS cord-347946-i6kx3n6m 106 38 of of IN cord-347946-i6kx3n6m 106 39 acute acute JJ cord-347946-i6kx3n6m 106 40 and/ and/ CD cord-347946-i6kx3n6m 106 41 or or CC cord-347946-i6kx3n6m 106 42 psychosocial psychosocial JJ cord-347946-i6kx3n6m 106 43 stressors stressor NNS cord-347946-i6kx3n6m 106 44 most most RBS cord-347946-i6kx3n6m 106 45 likely likely JJ cord-347946-i6kx3n6m 106 46 to to TO cord-347946-i6kx3n6m 106 47 be be VB cord-347946-i6kx3n6m 106 48 associated associate VBN cord-347946-i6kx3n6m 106 49 with with IN cord-347946-i6kx3n6m 106 50 immediate immediate JJ cord-347946-i6kx3n6m 106 51 risk risk NN cord-347946-i6kx3n6m 106 52 of of IN cord-347946-i6kx3n6m 106 53 wounding wounding NN cord-347946-i6kx3n6m 106 54 and and CC cord-347946-i6kx3n6m 106 55 hence hence RB cord-347946-i6kx3n6m 106 56 infection infection NN cord-347946-i6kx3n6m 106 57 activate activate VBP cord-347946-i6kx3n6m 106 58 both both DT cord-347946-i6kx3n6m 106 59 innate innate JJ cord-347946-i6kx3n6m 106 60 and and CC cord-347946-i6kx3n6m 106 61 adaptive adaptive JJ cord-347946-i6kx3n6m 106 62 immunity immunity NN cord-347946-i6kx3n6m 107 1 ( ( -LRB- cord-347946-i6kx3n6m 107 2 Quan Quan NNP cord-347946-i6kx3n6m 107 3 et et NNP cord-347946-i6kx3n6m 107 4 al al NNP cord-347946-i6kx3n6m 107 5 , , , cord-347946-i6kx3n6m 107 6 2001 2001 CD cord-347946-i6kx3n6m 107 7 ; ; : cord-347946-i6kx3n6m 107 8 Bierhaus Bierhaus NNP cord-347946-i6kx3n6m 107 9 et et NNP cord-347946-i6kx3n6m 107 10 al al NNP cord-347946-i6kx3n6m 107 11 , , , cord-347946-i6kx3n6m 107 12 2003 2003 CD cord-347946-i6kx3n6m 107 13 ; ; : cord-347946-i6kx3n6m 107 14 Avitsur Avitsur NNP cord-347946-i6kx3n6m 107 15 et et NNP cord-347946-i6kx3n6m 107 16 al al NNP cord-347946-i6kx3n6m 107 17 , , , cord-347946-i6kx3n6m 107 18 2005 2005 CD cord-347946-i6kx3n6m 107 19 ; ; : cord-347946-i6kx3n6m 107 20 Viswanathan Viswanathan NNP cord-347946-i6kx3n6m 107 21 et et NNP cord-347946-i6kx3n6m 107 22 al al NNP cord-347946-i6kx3n6m 107 23 , , , cord-347946-i6kx3n6m 107 24 2005 2005 CD cord-347946-i6kx3n6m 107 25 ; ; : cord-347946-i6kx3n6m 107 26 Pace Pace NNP cord-347946-i6kx3n6m 107 27 et et NNP cord-347946-i6kx3n6m 107 28 al al NNP cord-347946-i6kx3n6m 107 29 , , , cord-347946-i6kx3n6m 107 30 2006b 2006b CD cord-347946-i6kx3n6m 107 31 ; ; : cord-347946-i6kx3n6m 107 32 Steptoe Steptoe NNP cord-347946-i6kx3n6m 107 33 et et NNP cord-347946-i6kx3n6m 107 34 al al NNP cord-347946-i6kx3n6m 107 35 , , , cord-347946-i6kx3n6m 107 36 2007 2007 CD cord-347946-i6kx3n6m 107 37 ; ; : cord-347946-i6kx3n6m 107 38 Joachim Joachim NNP cord-347946-i6kx3n6m 107 39 et et NNP cord-347946-i6kx3n6m 107 40 al al NNP cord-347946-i6kx3n6m 107 41 , , , cord-347946-i6kx3n6m 107 42 2008 2008 CD cord-347946-i6kx3n6m 107 43 ; ; : cord-347946-i6kx3n6m 107 44 Bailey Bailey NNP cord-347946-i6kx3n6m 107 45 et et NNP cord-347946-i6kx3n6m 107 46 al al NNP cord-347946-i6kx3n6m 107 47 , , , cord-347946-i6kx3n6m 107 48 2009 2009 CD cord-347946-i6kx3n6m 107 49 ; ; : cord-347946-i6kx3n6m 107 50 Rosenberger Rosenberger NNP cord-347946-i6kx3n6m 107 51 et et NNP cord-347946-i6kx3n6m 107 52 al al NNP cord-347946-i6kx3n6m 107 53 , , , cord-347946-i6kx3n6m 107 54 2009 2009 CD cord-347946-i6kx3n6m 107 55 ; ; : cord-347946-i6kx3n6m 107 56 Mays Mays NNP cord-347946-i6kx3n6m 107 57 et et NNP cord-347946-i6kx3n6m 107 58 al al NNP cord-347946-i6kx3n6m 107 59 , , , cord-347946-i6kx3n6m 107 60 2010 2010 CD cord-347946-i6kx3n6m 107 61 ; ; : cord-347946-i6kx3n6m 107 62 Powell Powell NNP cord-347946-i6kx3n6m 107 63 et et NNP cord-347946-i6kx3n6m 107 64 al al NNP cord-347946-i6kx3n6m 107 65 , , , cord-347946-i6kx3n6m 107 66 2010 2010 CD cord-347946-i6kx3n6m 107 67 ) ) -RRB- cord-347946-i6kx3n6m 107 68 . . . cord-347946-i6kx3n6m 108 1 That that IN cord-347946-i6kx3n6m 108 2 non non JJ cord-347946-i6kx3n6m 108 3 - - JJ cord-347946-i6kx3n6m 108 4 immune immune JJ cord-347946-i6kx3n6m 108 5 stressors stressor NNS cord-347946-i6kx3n6m 108 6 can can MD cord-347946-i6kx3n6m 108 7 activate activate VB cord-347946-i6kx3n6m 108 8 inflammationand inflammationand NN cord-347946-i6kx3n6m 108 9 do do VB cord-347946-i6kx3n6m 108 10 so so RB cord-347946-i6kx3n6m 108 11 via via IN cord-347946-i6kx3n6m 108 12 multiple multiple JJ cord-347946-i6kx3n6m 108 13 mechanisms mechanism NNS cord-347946-i6kx3n6m 108 14 including include VBG cord-347946-i6kx3n6m 108 15 activation activation NN cord-347946-i6kx3n6m 108 16 of of IN cord-347946-i6kx3n6m 108 17 the the DT cord-347946-i6kx3n6m 108 18 intracellular intracellular JJ cord-347946-i6kx3n6m 108 19 inflammasomes inflammasome NNS cord-347946-i6kx3n6m 108 20 - - : cord-347946-i6kx3n6m 108 21 is be VBZ cord-347946-i6kx3n6m 108 22 now now RB cord-347946-i6kx3n6m 108 23 firmly firmly RB cord-347946-i6kx3n6m 108 24 established establish VBN cord-347946-i6kx3n6m 108 25 ( ( -LRB- cord-347946-i6kx3n6m 108 26 Miller Miller NNP cord-347946-i6kx3n6m 108 27 and and CC cord-347946-i6kx3n6m 108 28 Raison Raison NNP cord-347946-i6kx3n6m 108 29 , , , cord-347946-i6kx3n6m 108 30 2015 2015 CD cord-347946-i6kx3n6m 108 31 ) ) -RRB- cord-347946-i6kx3n6m 108 32 . . . cord-347946-i6kx3n6m 109 1 However however RB cord-347946-i6kx3n6m 109 2 , , , cord-347946-i6kx3n6m 109 3 PATHOS pathos NN cord-347946-i6kx3n6m 109 4 - - HYPH cord-347946-i6kx3n6m 109 5 D D NNP cord-347946-i6kx3n6m 109 6 also also RB cord-347946-i6kx3n6m 109 7 predicts predict VBZ cord-347946-i6kx3n6m 109 8 that that IN cord-347946-i6kx3n6m 109 9 stress stress NN cord-347946-i6kx3n6m 109 10 - - HYPH cord-347946-i6kx3n6m 109 11 induced induce VBN cord-347946-i6kx3n6m 109 12 immune immune JJ cord-347946-i6kx3n6m 109 13 changes change NNS cord-347946-i6kx3n6m 109 14 should should MD cord-347946-i6kx3n6m 109 15 produce produce VB cord-347946-i6kx3n6m 109 16 an an DT cord-347946-i6kx3n6m 109 17 overall overall JJ cord-347946-i6kx3n6m 109 18 enhancement enhancement NN cord-347946-i6kx3n6m 109 19 of of IN cord-347946-i6kx3n6m 109 20 pathogen pathogen NN cord-347946-i6kx3n6m 109 21 - - HYPH cord-347946-i6kx3n6m 109 22 host host NN cord-347946-i6kx3n6m 109 23 defense defense NN cord-347946-i6kx3n6m 109 24 and and CC cord-347946-i6kx3n6m 109 25 especially especially RB cord-347946-i6kx3n6m 109 26 anti anti JJ cord-347946-i6kx3n6m 109 27 - - JJ cord-347946-i6kx3n6m 109 28 bacterial bacterial JJ cord-347946-i6kx3n6m 109 29 defense defense NN cord-347946-i6kx3n6m 109 30 given give VBN cord-347946-i6kx3n6m 109 31 that that IN cord-347946-i6kx3n6m 109 32 these these DT cord-347946-i6kx3n6m 109 33 organisms organism NNS cord-347946-i6kx3n6m 109 34 are be VBP cord-347946-i6kx3n6m 109 35 the the DT cord-347946-i6kx3n6m 109 36 chief chief JJ cord-347946-i6kx3n6m 109 37 cause cause NN cord-347946-i6kx3n6m 109 38 of of IN cord-347946-i6kx3n6m 109 39 wound wound NN cord-347946-i6kx3n6m 109 40 - - HYPH cord-347946-i6kx3n6m 109 41 related relate VBN cord-347946-i6kx3n6m 109 42 infections infection NNS cord-347946-i6kx3n6m 109 43 . . . cord-347946-i6kx3n6m 110 1 This this DT cord-347946-i6kx3n6m 110 2 has have VBZ cord-347946-i6kx3n6m 110 3 yet yet RB cord-347946-i6kx3n6m 110 4 to to TO cord-347946-i6kx3n6m 110 5 be be VB cord-347946-i6kx3n6m 110 6 proven prove VBN cord-347946-i6kx3n6m 110 7 or or CC cord-347946-i6kx3n6m 110 8 disproven disproven VBN cord-347946-i6kx3n6m 110 9 , , , cord-347946-i6kx3n6m 110 10 but but CC cord-347946-i6kx3n6m 110 11 significant significant JJ cord-347946-i6kx3n6m 110 12 animal animal NN cord-347946-i6kx3n6m 110 13 data datum NNS cord-347946-i6kx3n6m 110 14 suggest suggest VBP cord-347946-i6kx3n6m 110 15 that that IN cord-347946-i6kx3n6m 110 16 psychosocial psychosocial JJ cord-347946-i6kx3n6m 110 17 stressors stressor NNS cord-347946-i6kx3n6m 110 18 - - : cord-347946-i6kx3n6m 110 19 even even RB cord-347946-i6kx3n6m 110 20 when when WRB cord-347946-i6kx3n6m 110 21 recurrentcan recurrentcan NNP cord-347946-i6kx3n6m 110 22 enhance enhance VB cord-347946-i6kx3n6m 110 23 host host NN cord-347946-i6kx3n6m 110 24 defense defense NN cord-347946-i6kx3n6m 110 25 mechanisms mechanism NNS cord-347946-i6kx3n6m 110 26 and and CC cord-347946-i6kx3n6m 110 27 improve improve VB cord-347946-i6kx3n6m 110 28 immune immune JJ cord-347946-i6kx3n6m 110 29 function function NN cord-347946-i6kx3n6m 110 30 . . . cord-347946-i6kx3n6m 111 1 Using use VBG cord-347946-i6kx3n6m 111 2 a a DT cord-347946-i6kx3n6m 111 3 repeated repeat VBN cord-347946-i6kx3n6m 111 4 social social JJ cord-347946-i6kx3n6m 111 5 defeat defeat NN cord-347946-i6kx3n6m 111 6 stress stress NN cord-347946-i6kx3n6m 111 7 paradigm paradigm NN cord-347946-i6kx3n6m 111 8 ( ( -LRB- cord-347946-i6kx3n6m 111 9 SDR SDR NNP cord-347946-i6kx3n6m 111 10 ) ) -RRB- cord-347946-i6kx3n6m 111 11 , , , cord-347946-i6kx3n6m 111 12 Sheridan Sheridan NNP cord-347946-i6kx3n6m 111 13 and and CC cord-347946-i6kx3n6m 111 14 colleagues colleague NNS cord-347946-i6kx3n6m 111 15 have have VBP cord-347946-i6kx3n6m 111 16 shown show VBN cord-347946-i6kx3n6m 111 17 that that IN cord-347946-i6kx3n6m 111 18 stress stress NN cord-347946-i6kx3n6m 111 19 primes prime VBZ cord-347946-i6kx3n6m 111 20 multiple multiple JJ cord-347946-i6kx3n6m 111 21 aspects aspect NNS cord-347946-i6kx3n6m 111 22 of of IN cord-347946-i6kx3n6m 111 23 the the DT cord-347946-i6kx3n6m 111 24 rodent rodent NN cord-347946-i6kx3n6m 111 25 host host NN cord-347946-i6kx3n6m 111 26 defense defense NN cord-347946-i6kx3n6m 111 27 repertoire repertoire NN cord-347946-i6kx3n6m 111 28 . . . cord-347946-i6kx3n6m 112 1 SDR SDR NNP cord-347946-i6kx3n6m 112 2 increases increase VBZ cord-347946-i6kx3n6m 112 3 the the DT cord-347946-i6kx3n6m 112 4 bactericidal bactericidal JJ cord-347946-i6kx3n6m 112 5 activity activity NN cord-347946-i6kx3n6m 112 6 of of IN cord-347946-i6kx3n6m 112 7 splenic splenic JJ cord-347946-i6kx3n6m 112 8 macrophages macrophage NNS cord-347946-i6kx3n6m 112 9 through through IN cord-347946-i6kx3n6m 112 10 a a DT cord-347946-i6kx3n6m 112 11 Toll Toll NNP cord-347946-i6kx3n6m 112 12 - - HYPH cord-347946-i6kx3n6m 112 13 like like JJ cord-347946-i6kx3n6m 112 14 receptor receptor NN cord-347946-i6kx3n6m 112 15 - - HYPH cord-347946-i6kx3n6m 112 16 dependent dependent JJ cord-347946-i6kx3n6m 112 17 pathway pathway NN cord-347946-i6kx3n6m 112 18 ; ; . cord-347946-i6kx3n6m 113 1 ( ( -LRB- cord-347946-i6kx3n6m 113 2 Bailey Bailey NNP cord-347946-i6kx3n6m 113 3 et et NNP cord-347946-i6kx3n6m 113 4 al al NNP cord-347946-i6kx3n6m 113 5 , , , cord-347946-i6kx3n6m 113 6 2007 2007 CD cord-347946-i6kx3n6m 113 7 ) ) -RRB- cord-347946-i6kx3n6m 113 8 enhances enhance VBZ cord-347946-i6kx3n6m 113 9 the the DT cord-347946-i6kx3n6m 113 10 innate innate JJ cord-347946-i6kx3n6m 113 11 immune immune JJ cord-347946-i6kx3n6m 113 12 response response NN cord-347946-i6kx3n6m 113 13 to to IN cord-347946-i6kx3n6m 113 14 a a DT cord-347946-i6kx3n6m 113 15 primary primary JJ cord-347946-i6kx3n6m 113 16 HSV-1 HSV-1 NNP cord-347946-i6kx3n6m 113 17 infection infection NN cord-347946-i6kx3n6m 113 18 in in IN cord-347946-i6kx3n6m 113 19 the the DT cord-347946-i6kx3n6m 113 20 cornea cornea NN cord-347946-i6kx3n6m 113 21 and and CC cord-347946-i6kx3n6m 113 22 trigeminal trigeminal JJ cord-347946-i6kx3n6m 113 23 ganglia ganglion NNS cord-347946-i6kx3n6m 113 24 ; ; : cord-347946-i6kx3n6m 114 1 ( ( -LRB- cord-347946-i6kx3n6m 114 2 Dong Dong NNP cord-347946-i6kx3n6m 114 3 - - HYPH cord-347946-i6kx3n6m 114 4 Newsom Newsom NNP cord-347946-i6kx3n6m 114 5 et et NNP cord-347946-i6kx3n6m 114 6 al al NNP cord-347946-i6kx3n6m 114 7 , , , cord-347946-i6kx3n6m 114 8 2010 2010 CD cord-347946-i6kx3n6m 114 9 ) ) -RRB- cord-347946-i6kx3n6m 114 10 primes prime NNS cord-347946-i6kx3n6m 114 11 dendritic dendritic JJ cord-347946-i6kx3n6m 114 12 cells cell NNS cord-347946-i6kx3n6m 114 13 and and CC cord-347946-i6kx3n6m 114 14 augments augment VBZ cord-347946-i6kx3n6m 114 15 clonal clonal JJ cord-347946-i6kx3n6m 114 16 expansion expansion NN cord-347946-i6kx3n6m 114 17 of of IN cord-347946-i6kx3n6m 114 18 CD8(+)T CD8(+)T NNP cord-347946-i6kx3n6m 114 19 cells cell NNS cord-347946-i6kx3n6m 114 20 during during IN cord-347946-i6kx3n6m 114 21 primary primary JJ cord-347946-i6kx3n6m 114 22 influenza influenza NN cord-347946-i6kx3n6m 114 23 A a DT cord-347946-i6kx3n6m 114 24 viral viral JJ cord-347946-i6kx3n6m 114 25 infection infection NN cord-347946-i6kx3n6m 114 26 with with IN cord-347946-i6kx3n6m 114 27 a a DT cord-347946-i6kx3n6m 114 28 resultant resultant JJ cord-347946-i6kx3n6m 114 29 enhancement enhancement NN cord-347946-i6kx3n6m 114 30 of of IN cord-347946-i6kx3n6m 114 31 adaptive adaptive JJ cord-347946-i6kx3n6m 114 32 immunity immunity NN cord-347946-i6kx3n6m 114 33 and and CC cord-347946-i6kx3n6m 114 34 viral viral JJ cord-347946-i6kx3n6m 114 35 clearance clearance NN cord-347946-i6kx3n6m 114 36 ; ; : cord-347946-i6kx3n6m 114 37 Mays Mays NNP cord-347946-i6kx3n6m 114 38 et et NNP cord-347946-i6kx3n6m 114 39 al al NNP cord-347946-i6kx3n6m 114 40 , , , cord-347946-i6kx3n6m 114 41 2012 2012 CD cord-347946-i6kx3n6m 114 42 ) ) -RRB- cord-347946-i6kx3n6m 114 43 and and CC cord-347946-i6kx3n6m 114 44 activates activate VBZ cord-347946-i6kx3n6m 114 45 natural natural JJ cord-347946-i6kx3n6m 114 46 killer killer NN cord-347946-i6kx3n6m 114 47 cells cell NNS cord-347946-i6kx3n6m 115 1 ( ( -LRB- cord-347946-i6kx3n6m 115 2 Tarr Tarr NNP cord-347946-i6kx3n6m 115 3 et et NNP cord-347946-i6kx3n6m 115 4 al al NNP cord-347946-i6kx3n6m 115 5 , , , cord-347946-i6kx3n6m 115 6 2012b 2012b CD cord-347946-i6kx3n6m 115 7 ) ) -RRB- cord-347946-i6kx3n6m 115 8 . . . cord-347946-i6kx3n6m 116 1 To to IN cord-347946-i6kx3n6m 116 2 our -PRON- PRP$ cord-347946-i6kx3n6m 116 3 knowledge knowledge NN cord-347946-i6kx3n6m 116 4 , , , cord-347946-i6kx3n6m 116 5 none none NN cord-347946-i6kx3n6m 116 6 of of IN cord-347946-i6kx3n6m 116 7 these these DT cord-347946-i6kx3n6m 116 8 effects effect NNS cord-347946-i6kx3n6m 116 9 have have VBP cord-347946-i6kx3n6m 116 10 been be VBN cord-347946-i6kx3n6m 116 11 directly directly RB cord-347946-i6kx3n6m 116 12 examined examine VBN cord-347946-i6kx3n6m 116 13 in in IN cord-347946-i6kx3n6m 116 14 humans human NNS cord-347946-i6kx3n6m 116 15 , , , cord-347946-i6kx3n6m 116 16 but but CC cord-347946-i6kx3n6m 116 17 it -PRON- PRP cord-347946-i6kx3n6m 116 18 is be VBZ cord-347946-i6kx3n6m 116 19 intriguing intriguing JJ cord-347946-i6kx3n6m 116 20 to to TO cord-347946-i6kx3n6m 116 21 note note VB cord-347946-i6kx3n6m 116 22 that that IN cord-347946-i6kx3n6m 116 23 improved improve VBN cord-347946-i6kx3n6m 116 24 functional functional JJ cord-347946-i6kx3n6m 116 25 recovery recovery NN cord-347946-i6kx3n6m 116 26 following follow VBG cord-347946-i6kx3n6m 116 27 knee knee NN cord-347946-i6kx3n6m 116 28 surgery surgery NN cord-347946-i6kx3n6m 116 29 has have VBZ cord-347946-i6kx3n6m 116 30 been be VBN cord-347946-i6kx3n6m 116 31 associated associate VBN cord-347946-i6kx3n6m 116 32 with with IN cord-347946-i6kx3n6m 116 33 an an DT cord-347946-i6kx3n6m 116 34 increase increase NN cord-347946-i6kx3n6m 116 35 in in IN cord-347946-i6kx3n6m 116 36 the the DT cord-347946-i6kx3n6m 116 37 type type NN cord-347946-i6kx3n6m 116 38 of of IN cord-347946-i6kx3n6m 116 39 immune immune JJ cord-347946-i6kx3n6m 116 40 cell cell NN cord-347946-i6kx3n6m 116 41 redistribution redistribution NN cord-347946-i6kx3n6m 116 42 effects effect NNS cord-347946-i6kx3n6m 116 43 that that WDT cord-347946-i6kx3n6m 116 44 are be VBP cord-347946-i6kx3n6m 116 45 known know VBN cord-347946-i6kx3n6m 116 46 to to TO cord-347946-i6kx3n6m 116 47 be be VB cord-347946-i6kx3n6m 116 48 induced induce VBN cord-347946-i6kx3n6m 116 49 by by IN cord-347946-i6kx3n6m 116 50 acute acute JJ cord-347946-i6kx3n6m 116 51 stress stress NN cord-347946-i6kx3n6m 116 52 in in IN cord-347946-i6kx3n6m 116 53 animals animal NNS cord-347946-i6kx3n6m 116 54 ( ( -LRB- cord-347946-i6kx3n6m 116 55 Rosenberger Rosenberger NNP cord-347946-i6kx3n6m 116 56 et et NNP cord-347946-i6kx3n6m 116 57 al al NNP cord-347946-i6kx3n6m 116 58 , , , cord-347946-i6kx3n6m 116 59 2009 2009 CD cord-347946-i6kx3n6m 116 60 ) ) -RRB- cord-347946-i6kx3n6m 116 61 . . . cord-347946-i6kx3n6m 117 1 Also also RB cord-347946-i6kx3n6m 117 2 relevant relevant JJ cord-347946-i6kx3n6m 117 3 to to IN cord-347946-i6kx3n6m 117 4 the the DT cord-347946-i6kx3n6m 117 5 hypothesis hypothesis NN cord-347946-i6kx3n6m 117 6 that that IN cord-347946-i6kx3n6m 117 7 stress stress NN cord-347946-i6kx3n6m 117 8 - - HYPH cord-347946-i6kx3n6m 117 9 induced induce VBN cord-347946-i6kx3n6m 117 10 activation activation NN cord-347946-i6kx3n6m 117 11 of of IN cord-347946-i6kx3n6m 117 12 inflammation inflammation NN cord-347946-i6kx3n6m 117 13 provides provide VBZ cord-347946-i6kx3n6m 117 14 pre pre JJ cord-347946-i6kx3n6m 117 15 - - JJ cord-347946-i6kx3n6m 117 16 potent potent JJ cord-347946-i6kx3n6m 117 17 protection protection NN cord-347946-i6kx3n6m 117 18 against against IN cord-347946-i6kx3n6m 117 19 pathogens pathogen NNS cord-347946-i6kx3n6m 117 20 is be VBZ cord-347946-i6kx3n6m 117 21 work work NN cord-347946-i6kx3n6m 117 22 by by IN cord-347946-i6kx3n6m 117 23 Cole Cole NNP cord-347946-i6kx3n6m 117 24 and and CC cord-347946-i6kx3n6m 117 25 colleagues colleague NNS cord-347946-i6kx3n6m 117 26 demonstrating demonstrate VBG cord-347946-i6kx3n6m 117 27 that that IN cord-347946-i6kx3n6m 117 28 social social JJ cord-347946-i6kx3n6m 117 29 isolation isolation NN cord-347946-i6kx3n6m 117 30 is be VBZ cord-347946-i6kx3n6m 117 31 associated associate VBN cord-347946-i6kx3n6m 117 32 with with IN cord-347946-i6kx3n6m 117 33 an an DT cord-347946-i6kx3n6m 117 34 immune immune JJ cord-347946-i6kx3n6m 117 35 signature signature NN cord-347946-i6kx3n6m 117 36 well well RB cord-347946-i6kx3n6m 117 37 - - HYPH cord-347946-i6kx3n6m 117 38 tailored tailor VBN cord-347946-i6kx3n6m 117 39 to to IN cord-347946-i6kx3n6m 117 40 the the DT cord-347946-i6kx3n6m 117 41 types type NNS cord-347946-i6kx3n6m 117 42 of of IN cord-347946-i6kx3n6m 117 43 infectious infectious JJ cord-347946-i6kx3n6m 117 44 challenges challenge NNS cord-347946-i6kx3n6m 117 45 that that WDT cord-347946-i6kx3n6m 117 46 would would MD cord-347946-i6kx3n6m 117 47 most most RBS cord-347946-i6kx3n6m 117 48 likely likely RB cord-347946-i6kx3n6m 117 49 have have VB cord-347946-i6kx3n6m 117 50 resulted result VBN cord-347946-i6kx3n6m 117 51 from from IN cord-347946-i6kx3n6m 117 52 ostracism ostracism NN cord-347946-i6kx3n6m 117 53 in in IN cord-347946-i6kx3n6m 117 54 ancestral ancestral JJ cord-347946-i6kx3n6m 117 55 environments environment NNS cord-347946-i6kx3n6m 117 56 . . . cord-347946-i6kx3n6m 118 1 Individuals individual NNS cord-347946-i6kx3n6m 118 2 who who WP cord-347946-i6kx3n6m 118 3 perceive perceive VBP cord-347946-i6kx3n6m 118 4 themselves -PRON- PRP cord-347946-i6kx3n6m 118 5 as as RB cord-347946-i6kx3n6m 118 6 chronically chronically RB cord-347946-i6kx3n6m 118 7 socially socially RB cord-347946-i6kx3n6m 118 8 isolated isolate VBN cord-347946-i6kx3n6m 118 9 ( ( -LRB- cord-347946-i6kx3n6m 118 10 ie ie FW cord-347946-i6kx3n6m 118 11 . . . cord-347946-i6kx3n6m 119 1 lonely lonely NNP cord-347946-i6kx3n6m 119 2 ) ) -RRB- cord-347946-i6kx3n6m 119 3 show show VBP cord-347946-i6kx3n6m 119 4 a a DT cord-347946-i6kx3n6m 119 5 pattern pattern NN cord-347946-i6kx3n6m 119 6 of of IN cord-347946-i6kx3n6m 119 7 gene gene NN cord-347946-i6kx3n6m 119 8 transcription transcription NN cord-347946-i6kx3n6m 119 9 in in IN cord-347946-i6kx3n6m 119 10 leukocytes leukocyte NNS cord-347946-i6kx3n6m 119 11 characterized characterize VBN cord-347946-i6kx3n6m 119 12 by by IN cord-347946-i6kx3n6m 119 13 increased increase VBN cord-347946-i6kx3n6m 119 14 expression expression NN cord-347946-i6kx3n6m 119 15 of of IN cord-347946-i6kx3n6m 119 16 inflammatory inflammatory JJ cord-347946-i6kx3n6m 119 17 pathways pathway NNS cord-347946-i6kx3n6m 119 18 crucial crucial JJ cord-347946-i6kx3n6m 119 19 for for IN cord-347946-i6kx3n6m 119 20 protection protection NN cord-347946-i6kx3n6m 119 21 against against IN cord-347946-i6kx3n6m 119 22 bacteria bacteria NNS cord-347946-i6kx3n6m 119 23 with with IN cord-347946-i6kx3n6m 119 24 a a DT cord-347946-i6kx3n6m 119 25 concomitant concomitant JJ cord-347946-i6kx3n6m 119 26 decrease decrease NN cord-347946-i6kx3n6m 119 27 in in IN cord-347946-i6kx3n6m 119 28 the the DT cord-347946-i6kx3n6m 119 29 expression expression NN cord-347946-i6kx3n6m 119 30 of of IN cord-347946-i6kx3n6m 119 31 genes gene NNS cord-347946-i6kx3n6m 119 32 important important JJ cord-347946-i6kx3n6m 119 33 for for IN cord-347946-i6kx3n6m 119 34 antiviral antiviral JJ cord-347946-i6kx3n6m 119 35 immunity immunity NN cord-347946-i6kx3n6m 119 36 , , , cord-347946-i6kx3n6m 119 37 especially especially RB cord-347946-i6kx3n6m 119 38 interferon interferon NN cord-347946-i6kx3n6m 119 39 response response NN cord-347946-i6kx3n6m 119 40 genes gene NNS cord-347946-i6kx3n6m 119 41 ( ( -LRB- cord-347946-i6kx3n6m 119 42 Slavich Slavich NNP cord-347946-i6kx3n6m 119 43 and and CC cord-347946-i6kx3n6m 119 44 Cole Cole NNP cord-347946-i6kx3n6m 119 45 , , , cord-347946-i6kx3n6m 119 46 2013 2013 CD cord-347946-i6kx3n6m 119 47 ) ) -RRB- cord-347946-i6kx3n6m 119 48 . . . cord-347946-i6kx3n6m 120 1 Consistent consistent JJ cord-347946-i6kx3n6m 120 2 with with IN cord-347946-i6kx3n6m 120 3 these these DT cord-347946-i6kx3n6m 120 4 findings finding NNS cord-347946-i6kx3n6m 120 5 , , , cord-347946-i6kx3n6m 120 6 individuals individual NNS cord-347946-i6kx3n6m 120 7 with with IN cord-347946-i6kx3n6m 120 8 high high JJ cord-347946-i6kx3n6m 120 9 trait trait NN cord-347946-i6kx3n6m 120 10 sensitivity sensitivity NN cord-347946-i6kx3n6m 120 11 to to IN cord-347946-i6kx3n6m 120 12 social social JJ cord-347946-i6kx3n6m 120 13 disconnection disconnection NN cord-347946-i6kx3n6m 120 14 produce produce VBP cord-347946-i6kx3n6m 120 15 greater great JJR cord-347946-i6kx3n6m 120 16 blood blood NN cord-347946-i6kx3n6m 120 17 levels level NNS cord-347946-i6kx3n6m 120 18 of of IN cord-347946-i6kx3n6m 120 19 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 120 20 cytokines cytokine NNS cord-347946-i6kx3n6m 120 21 ( ( -LRB- cord-347946-i6kx3n6m 120 22 TNF TNF NNP cord-347946-i6kx3n6m 120 23 and and CC cord-347946-i6kx3n6m 120 24 IL-6 IL-6 NNP cord-347946-i6kx3n6m 120 25 ) ) -RRB- cord-347946-i6kx3n6m 120 26 and and CC cord-347946-i6kx3n6m 120 27 increased increase VBN cord-347946-i6kx3n6m 120 28 expression expression NN cord-347946-i6kx3n6m 120 29 of of IN cord-347946-i6kx3n6m 120 30 inflammatory inflammatory JJ cord-347946-i6kx3n6m 120 31 genes gene NNS cord-347946-i6kx3n6m 120 32 in in IN cord-347946-i6kx3n6m 120 33 response response NN cord-347946-i6kx3n6m 120 34 to to IN cord-347946-i6kx3n6m 120 35 an an DT cord-347946-i6kx3n6m 120 36 endotoxin endotoxin NN cord-347946-i6kx3n6m 120 37 stimulus stimulus NN cord-347946-i6kx3n6m 120 38 ( ( -LRB- cord-347946-i6kx3n6m 120 39 Moieni Moieni NNP cord-347946-i6kx3n6m 120 40 et et NNP cord-347946-i6kx3n6m 120 41 al al NNP cord-347946-i6kx3n6m 120 42 , , , cord-347946-i6kx3n6m 120 43 2015a 2015a CD cord-347946-i6kx3n6m 120 44 ) ) -RRB- cord-347946-i6kx3n6m 120 45 . . . cord-347946-i6kx3n6m 121 1 Similarly similarly RB cord-347946-i6kx3n6m 121 2 , , , cord-347946-i6kx3n6m 121 3 study study NN cord-347946-i6kx3n6m 121 4 participants participant NNS cord-347946-i6kx3n6m 121 5 who who WP cord-347946-i6kx3n6m 121 6 responded respond VBD cord-347946-i6kx3n6m 121 7 to to IN cord-347946-i6kx3n6m 121 8 an an DT cord-347946-i6kx3n6m 121 9 fMRI fmri NN cord-347946-i6kx3n6m 121 10 - - HYPH cord-347946-i6kx3n6m 121 11 based base VBN cord-347946-i6kx3n6m 121 12 social social JJ cord-347946-i6kx3n6m 121 13 exclusion exclusion NN cord-347946-i6kx3n6m 121 14 paradigm paradigm NN cord-347946-i6kx3n6m 121 15 with with IN cord-347946-i6kx3n6m 121 16 greater great JJR cord-347946-i6kx3n6m 121 17 activity activity NN cord-347946-i6kx3n6m 121 18 in in IN cord-347946-i6kx3n6m 121 19 the the DT cord-347946-i6kx3n6m 121 20 dorsal dorsal JJ cord-347946-i6kx3n6m 121 21 anterior anterior NNP cord-347946-i6kx3n6m 121 22 cingulate cingulate NNP cord-347946-i6kx3n6m 121 23 cortex cortex NNP cord-347946-i6kx3n6m 121 24 and and CC cord-347946-i6kx3n6m 121 25 anterior anterior NNP cord-347946-i6kx3n6m 121 26 insula insula NN cord-347946-i6kx3n6m 121 27 - - HYPH cord-347946-i6kx3n6m 121 28 brain brain NN cord-347946-i6kx3n6m 121 29 regions region NNS cord-347946-i6kx3n6m 121 30 that that WDT cord-347946-i6kx3n6m 121 31 have have VBP cord-347946-i6kx3n6m 121 32 previously previously RB cord-347946-i6kx3n6m 121 33 been be VBN cord-347946-i6kx3n6m 121 34 associated associate VBN cord-347946-i6kx3n6m 121 35 with with IN cord-347946-i6kx3n6m 121 36 processing process VBG cord-347946-i6kx3n6m 121 37 rejection rejection NN cord-347946-i6kx3n6m 121 38 - - HYPH cord-347946-i6kx3n6m 121 39 related relate VBN cord-347946-i6kx3n6m 121 40 distress distress NN cord-347946-i6kx3n6m 121 41 and and CC cord-347946-i6kx3n6m 121 42 negative negative JJ cord-347946-i6kx3n6m 121 43 affect affect NN cord-347946-i6kx3n6m 121 44 - - : cord-347946-i6kx3n6m 121 45 also also RB cord-347946-i6kx3n6m 121 46 responded respond VBD cord-347946-i6kx3n6m 121 47 to to IN cord-347946-i6kx3n6m 121 48 a a DT cord-347946-i6kx3n6m 121 49 laboratory laboratory NN cord-347946-i6kx3n6m 121 50 psychosocial psychosocial JJ cord-347946-i6kx3n6m 121 51 stress stress NN cord-347946-i6kx3n6m 121 52 test test NN cord-347946-i6kx3n6m 121 53 with with IN cord-347946-i6kx3n6m 121 54 increased increase VBN cord-347946-i6kx3n6m 121 55 salivary salivary JJ cord-347946-i6kx3n6m 121 56 production production NN cord-347946-i6kx3n6m 121 57 of of IN cord-347946-i6kx3n6m 121 58 the the DT cord-347946-i6kx3n6m 121 59 inflammatory inflammatory JJ cord-347946-i6kx3n6m 121 60 biomarker biomarker NN cord-347946-i6kx3n6m 121 61 soluble soluble JJ cord-347946-i6kx3n6m 121 62 TNF TNF NNP cord-347946-i6kx3n6m 121 63 - - HYPH cord-347946-i6kx3n6m 121 64 α α NNP cord-347946-i6kx3n6m 121 65 type type NN cord-347946-i6kx3n6m 121 66 II II NNP cord-347946-i6kx3n6m 121 67 receptor receptor NN cord-347946-i6kx3n6m 122 1 ( ( -LRB- cord-347946-i6kx3n6m 122 2 Slavich Slavich NNP cord-347946-i6kx3n6m 122 3 et et NNP cord-347946-i6kx3n6m 122 4 al al NNP cord-347946-i6kx3n6m 122 5 , , , cord-347946-i6kx3n6m 122 6 2010 2010 CD cord-347946-i6kx3n6m 122 7 ) ) -RRB- cord-347946-i6kx3n6m 122 8 . . . cord-347946-i6kx3n6m 123 1 As as IN cord-347946-i6kx3n6m 123 2 Slavich Slavich NNP cord-347946-i6kx3n6m 123 3 and and CC cord-347946-i6kx3n6m 123 4 Cole Cole NNP cord-347946-i6kx3n6m 123 5 , , , cord-347946-i6kx3n6m 123 6 ( ( -LRB- cord-347946-i6kx3n6m 123 7 2013 2013 CD cord-347946-i6kx3n6m 123 8 ) ) -RRB- cord-347946-i6kx3n6m 123 9 have have VBP cord-347946-i6kx3n6m 123 10 observed observe VBN cord-347946-i6kx3n6m 123 11 , , , cord-347946-i6kx3n6m 123 12 this this DT cord-347946-i6kx3n6m 123 13 pattern pattern NN cord-347946-i6kx3n6m 123 14 of of IN cord-347946-i6kx3n6m 123 15 findings finding NNS cord-347946-i6kx3n6m 123 16 in in IN cord-347946-i6kx3n6m 123 17 response response NN cord-347946-i6kx3n6m 123 18 to to IN cord-347946-i6kx3n6m 123 19 social social JJ cord-347946-i6kx3n6m 123 20 isolation isolation NN cord-347946-i6kx3n6m 123 21 ( ( -LRB- cord-347946-i6kx3n6m 123 22 ie ie FW cord-347946-i6kx3n6m 123 23 , , , cord-347946-i6kx3n6m 123 24 increased increase VBN cord-347946-i6kx3n6m 123 25 inflammation inflammation NN cord-347946-i6kx3n6m 123 26 / / SYM cord-347946-i6kx3n6m 123 27 reduced reduce VBN cord-347946-i6kx3n6m 123 28 antiviral antiviral JJ cord-347946-i6kx3n6m 123 29 immunity immunity NN cord-347946-i6kx3n6m 123 30 ) ) -RRB- cord-347946-i6kx3n6m 123 31 may may MD cord-347946-i6kx3n6m 123 32 well well RB cord-347946-i6kx3n6m 123 33 have have VB cord-347946-i6kx3n6m 123 34 evolved evolve VBN cord-347946-i6kx3n6m 123 35 to to TO cord-347946-i6kx3n6m 123 36 optimize optimize VB cord-347946-i6kx3n6m 123 37 immune immune JJ cord-347946-i6kx3n6m 123 38 responses response NNS cord-347946-i6kx3n6m 123 39 to to IN cord-347946-i6kx3n6m 123 40 threats threat NNS cord-347946-i6kx3n6m 123 41 from from IN cord-347946-i6kx3n6m 123 42 environmental environmental JJ cord-347946-i6kx3n6m 123 43 pathogens pathogen NNS cord-347946-i6kx3n6m 123 44 associated associate VBN cord-347946-i6kx3n6m 123 45 with with IN cord-347946-i6kx3n6m 123 46 wounding wounding NN cord-347946-i6kx3n6m 123 47 / / SYM cord-347946-i6kx3n6m 123 48 starvation starvation NN cord-347946-i6kx3n6m 123 49 that that WDT cord-347946-i6kx3n6m 123 50 would would MD cord-347946-i6kx3n6m 123 51 have have VB cord-347946-i6kx3n6m 123 52 been be VBN cord-347946-i6kx3n6m 123 53 the the DT cord-347946-i6kx3n6m 123 54 primary primary JJ cord-347946-i6kx3n6m 123 55 risk risk NN cord-347946-i6kx3n6m 123 56 for for IN cord-347946-i6kx3n6m 123 57 infectious infectious JJ cord-347946-i6kx3n6m 123 58 morbidity morbidity NN cord-347946-i6kx3n6m 123 59 / / SYM cord-347946-i6kx3n6m 123 60 mortality mortality NN cord-347946-i6kx3n6m 123 61 in in IN cord-347946-i6kx3n6m 123 62 the the DT cord-347946-i6kx3n6m 123 63 EEA EEA NNP cord-347946-i6kx3n6m 123 64 for for IN cord-347946-i6kx3n6m 123 65 individuals individual NNS cord-347946-i6kx3n6m 123 66 with with IN cord-347946-i6kx3n6m 123 67 diminished diminished JJ cord-347946-i6kx3n6m 123 68 human human NN cord-347946-i6kx3n6m 123 69 - - HYPH cord-347946-i6kx3n6m 123 70 to to IN cord-347946-i6kx3n6m 123 71 - - HYPH cord-347946-i6kx3n6m 123 72 human human JJ cord-347946-i6kx3n6m 123 73 contact contact NN cord-347946-i6kx3n6m 123 74 . . . cord-347946-i6kx3n6m 124 1 Because because IN cord-347946-i6kx3n6m 124 2 ostracism ostracism NN cord-347946-i6kx3n6m 124 3 was be VBD cord-347946-i6kx3n6m 124 4 an an DT cord-347946-i6kx3n6m 124 5 almost almost RB cord-347946-i6kx3n6m 124 6 certain certain JJ cord-347946-i6kx3n6m 124 7 death death NN cord-347946-i6kx3n6m 124 8 sentence sentence NN cord-347946-i6kx3n6m 124 9 in in IN cord-347946-i6kx3n6m 124 10 ancestral ancestral JJ cord-347946-i6kx3n6m 124 11 environments environment NNS cord-347946-i6kx3n6m 124 12 , , , cord-347946-i6kx3n6m 124 13 the the DT cord-347946-i6kx3n6m 124 14 inflammatory inflammatory JJ cord-347946-i6kx3n6m 124 15 response response NN cord-347946-i6kx3n6m 124 16 induced induce VBN cord-347946-i6kx3n6m 124 17 by by IN cord-347946-i6kx3n6m 124 18 social social JJ cord-347946-i6kx3n6m 124 19 isolation isolation NN cord-347946-i6kx3n6m 124 20 / / SYM cord-347946-i6kx3n6m 124 21 exclusion exclusion NN cord-347946-i6kx3n6m 124 22 can can MD cord-347946-i6kx3n6m 124 23 be be VB cord-347946-i6kx3n6m 124 24 seen see VBN cord-347946-i6kx3n6m 124 25 as as IN cord-347946-i6kx3n6m 124 26 a a DT cord-347946-i6kx3n6m 124 27 modern modern JJ cord-347946-i6kx3n6m 124 28 vestige vestige NN cord-347946-i6kx3n6m 124 29 of of IN cord-347946-i6kx3n6m 124 30 what what WP cord-347946-i6kx3n6m 124 31 once once RB cord-347946-i6kx3n6m 124 32 served serve VBD cord-347946-i6kx3n6m 124 33 as as IN cord-347946-i6kx3n6m 124 34 an an DT cord-347946-i6kx3n6m 124 35 immunological immunological JJ cord-347946-i6kx3n6m 124 36 ostracism ostracism NN cord-347946-i6kx3n6m 124 37 detection detection NN cord-347946-i6kx3n6m 124 38 system system NN cord-347946-i6kx3n6m 124 39 that that WDT cord-347946-i6kx3n6m 124 40 worked work VBD cord-347946-i6kx3n6m 124 41 in in IN cord-347946-i6kx3n6m 124 42 concert concert NN cord-347946-i6kx3n6m 124 43 with with IN cord-347946-i6kx3n6m 124 44 other other JJ cord-347946-i6kx3n6m 124 45 ostracism ostracism NN cord-347946-i6kx3n6m 124 46 detection detection NN cord-347946-i6kx3n6m 124 47 systems system NNS cord-347946-i6kx3n6m 124 48 described describe VBN cord-347946-i6kx3n6m 124 49 in in IN cord-347946-i6kx3n6m 124 50 the the DT cord-347946-i6kx3n6m 124 51 literature literature NN cord-347946-i6kx3n6m 124 52 ( ( -LRB- cord-347946-i6kx3n6m 124 53 Spoor Spoor NNP cord-347946-i6kx3n6m 124 54 and and CC cord-347946-i6kx3n6m 124 55 Williams Williams NNP cord-347946-i6kx3n6m 124 56 , , , cord-347946-i6kx3n6m 124 57 2011 2011 CD cord-347946-i6kx3n6m 124 58 ) ) -RRB- cord-347946-i6kx3n6m 124 59 to to TO cord-347946-i6kx3n6m 124 60 encourage encourage VB cord-347946-i6kx3n6m 124 61 individuals individual NNS cord-347946-i6kx3n6m 124 62 to to TO cord-347946-i6kx3n6m 124 63 endure endure VB cord-347946-i6kx3n6m 124 64 the the DT cord-347946-i6kx3n6m 124 65 costs cost NNS cord-347946-i6kx3n6m 124 66 of of IN cord-347946-i6kx3n6m 124 67 group group NN cord-347946-i6kx3n6m 124 68 existence existence NN cord-347946-i6kx3n6m 124 69 during during IN cord-347946-i6kx3n6m 124 70 the the DT cord-347946-i6kx3n6m 124 71 long long JJ cord-347946-i6kx3n6m 124 72 years year NNS cord-347946-i6kx3n6m 124 73 of of IN cord-347946-i6kx3n6m 124 74 human human JJ cord-347946-i6kx3n6m 124 75 evolution evolution NN cord-347946-i6kx3n6m 124 76 . . . cord-347946-i6kx3n6m 125 1 This this DT cord-347946-i6kx3n6m 125 2 hypothesis hypothesis NN cord-347946-i6kx3n6m 125 3 might may MD cord-347946-i6kx3n6m 125 4 help help VB cord-347946-i6kx3n6m 125 5 explain explain VB cord-347946-i6kx3n6m 125 6 the the DT cord-347946-i6kx3n6m 125 7 recent recent JJ cord-347946-i6kx3n6m 125 8 finding finding NN cord-347946-i6kx3n6m 125 9 that that IN cord-347946-i6kx3n6m 125 10 cytokine cytokine NN cord-347946-i6kx3n6m 125 11 activation activation NN cord-347946-i6kx3n6m 125 12 via via IN cord-347946-i6kx3n6m 125 13 exposure exposure NN cord-347946-i6kx3n6m 125 14 to to IN cord-347946-i6kx3n6m 125 15 endotoxin endotoxin NN cord-347946-i6kx3n6m 125 16 induces induce VBZ cord-347946-i6kx3n6m 125 17 feelings feeling NNS cord-347946-i6kx3n6m 125 18 of of IN cord-347946-i6kx3n6m 125 19 social social JJ cord-347946-i6kx3n6m 125 20 disconnection disconnection NN cord-347946-i6kx3n6m 125 21 , , , cord-347946-i6kx3n6m 125 22 especially especially RB cord-347946-i6kx3n6m 125 23 in in IN cord-347946-i6kx3n6m 125 24 females female NNS cord-347946-i6kx3n6m 125 25 . . . cord-347946-i6kx3n6m 126 1 This this DT cord-347946-i6kx3n6m 126 2 phenomenon phenomenon NN cord-347946-i6kx3n6m 126 3 might may MD cord-347946-i6kx3n6m 126 4 reflect reflect VB cord-347946-i6kx3n6m 126 5 an an DT cord-347946-i6kx3n6m 126 6 evolved evolved JJ cord-347946-i6kx3n6m 126 7 and and CC cord-347946-i6kx3n6m 126 8 adaptive adaptive JJ cord-347946-i6kx3n6m 126 9 feedforward feedforward NN cord-347946-i6kx3n6m 126 10 mechanism mechanism NN cord-347946-i6kx3n6m 126 11 whereby whereby WRB cord-347946-i6kx3n6m 126 12 the the DT cord-347946-i6kx3n6m 126 13 risk risk NN cord-347946-i6kx3n6m 126 14 of of IN cord-347946-i6kx3n6m 126 15 social social JJ cord-347946-i6kx3n6m 126 16 exclusion exclusion NN cord-347946-i6kx3n6m 126 17 induced induce VBD cord-347946-i6kx3n6m 126 18 a a DT cord-347946-i6kx3n6m 126 19 prepotent prepotent NN cord-347946-i6kx3n6m 126 20 inflammatory inflammatory JJ cord-347946-i6kx3n6m 126 21 response response NN cord-347946-i6kx3n6m 126 22 that that WDT cord-347946-i6kx3n6m 126 23 then then RB cord-347946-i6kx3n6m 126 24 fostered foster VBD cord-347946-i6kx3n6m 126 25 a a DT cord-347946-i6kx3n6m 126 26 further further JJ cord-347946-i6kx3n6m 126 27 sensitivity sensitivity NN cord-347946-i6kx3n6m 126 28 to to IN cord-347946-i6kx3n6m 126 29 the the DT cord-347946-i6kx3n6m 126 30 risk risk NN cord-347946-i6kx3n6m 126 31 of of IN cord-347946-i6kx3n6m 126 32 ostracism ostracism NN cord-347946-i6kx3n6m 126 33 . . . cord-347946-i6kx3n6m 127 1 And and CC cord-347946-i6kx3n6m 127 2 this this DT cord-347946-i6kx3n6m 127 3 mechanism mechanism NN cord-347946-i6kx3n6m 127 4 may may MD cord-347946-i6kx3n6m 127 5 be be VB cord-347946-i6kx3n6m 127 6 more more RBR cord-347946-i6kx3n6m 127 7 apparent apparent JJ cord-347946-i6kx3n6m 127 8 in in IN cord-347946-i6kx3n6m 127 9 modern modern JJ cord-347946-i6kx3n6m 127 10 females female NNS cord-347946-i6kx3n6m 127 11 because because IN cord-347946-i6kx3n6m 127 12 the the DT cord-347946-i6kx3n6m 127 13 offspring offspring NN cord-347946-i6kx3n6m 127 14 of of IN cord-347946-i6kx3n6m 127 15 ostracized ostracize VBN cord-347946-i6kx3n6m 127 16 mothers mother NNS cord-347946-i6kx3n6m 127 17 would would MD cord-347946-i6kx3n6m 127 18 have have VB cord-347946-i6kx3n6m 127 19 been be VBN cord-347946-i6kx3n6m 127 20 less less RBR cord-347946-i6kx3n6m 127 21 likely likely JJ cord-347946-i6kx3n6m 127 22 to to TO cord-347946-i6kx3n6m 127 23 survive survive VB cord-347946-i6kx3n6m 127 24 than than IN cord-347946-i6kx3n6m 127 25 those those DT cord-347946-i6kx3n6m 127 26 of of IN cord-347946-i6kx3n6m 127 27 ostracized ostracize VBN cord-347946-i6kx3n6m 127 28 fathers father NNS cord-347946-i6kx3n6m 127 29 ( ( -LRB- cord-347946-i6kx3n6m 127 30 Sear Sear NNP cord-347946-i6kx3n6m 127 31 and and CC cord-347946-i6kx3n6m 127 32 Mace Mace NNP cord-347946-i6kx3n6m 127 33 , , , cord-347946-i6kx3n6m 127 34 2008 2008 CD cord-347946-i6kx3n6m 127 35 ) ) -RRB- cord-347946-i6kx3n6m 127 36 . . . cord-347946-i6kx3n6m 128 1 On on IN cord-347946-i6kx3n6m 128 2 the the DT cord-347946-i6kx3n6m 128 3 other other JJ cord-347946-i6kx3n6m 128 4 hand hand NN cord-347946-i6kx3n6m 128 5 , , , cord-347946-i6kx3n6m 128 6 the the DT cord-347946-i6kx3n6m 128 7 increased increase VBN cord-347946-i6kx3n6m 128 8 balance balance NN cord-347946-i6kx3n6m 128 9 of of IN cord-347946-i6kx3n6m 128 10 antiviral antiviral JJ cord-347946-i6kx3n6m 128 11 to to IN cord-347946-i6kx3n6m 128 12 anti anti JJ cord-347946-i6kx3n6m 128 13 - - JJ cord-347946-i6kx3n6m 128 14 bacterial bacterial JJ cord-347946-i6kx3n6m 128 15 / / SYM cord-347946-i6kx3n6m 128 16 inflammatory inflammatory JJ cord-347946-i6kx3n6m 128 17 gene gene NN cord-347946-i6kx3n6m 128 18 expression expression NN cord-347946-i6kx3n6m 128 19 seen see VBN cord-347946-i6kx3n6m 128 20 in in IN cord-347946-i6kx3n6m 128 21 more more RBR cord-347946-i6kx3n6m 128 22 socially socially RB cord-347946-i6kx3n6m 128 23 integrated integrate VBN cord-347946-i6kx3n6m 128 24 individuals individual NNS cord-347946-i6kx3n6m 128 25 would would MD cord-347946-i6kx3n6m 128 26 have have VB cord-347946-i6kx3n6m 128 27 been be VBN cord-347946-i6kx3n6m 128 28 more more RBR cord-347946-i6kx3n6m 128 29 optimal optimal JJ cord-347946-i6kx3n6m 128 30 for for IN cord-347946-i6kx3n6m 128 31 providing provide VBG cord-347946-i6kx3n6m 128 32 protection protection NN cord-347946-i6kx3n6m 128 33 against against IN cord-347946-i6kx3n6m 128 34 more more JJR cord-347946-i6kx3n6m 128 35 recent recent JJ cord-347946-i6kx3n6m 128 36 viral viral JJ cord-347946-i6kx3n6m 128 37 infections infection NNS cord-347946-i6kx3n6m 128 38 that that WDT cord-347946-i6kx3n6m 128 39 spread spread VBD cord-347946-i6kx3n6m 128 40 from from IN cord-347946-i6kx3n6m 128 41 person person NN cord-347946-i6kx3n6m 128 42 to to IN cord-347946-i6kx3n6m 128 43 person person NN cord-347946-i6kx3n6m 128 44 but but CC cord-347946-i6kx3n6m 128 45 that that IN cord-347946-i6kx3n6m 128 46 only only RB cord-347946-i6kx3n6m 128 47 became become VBD cord-347946-i6kx3n6m 128 48 widely widely RB cord-347946-i6kx3n6m 128 49 lethal lethal JJ cord-347946-i6kx3n6m 128 50 ( ( -LRB- cord-347946-i6kx3n6m 128 51 and and CC cord-347946-i6kx3n6m 128 52 thereby thereby RB cord-347946-i6kx3n6m 128 53 exerted exert VBN cord-347946-i6kx3n6m 128 54 greater great JJR cord-347946-i6kx3n6m 128 55 selection selection NN cord-347946-i6kx3n6m 128 56 pressure pressure NN cord-347946-i6kx3n6m 128 57 ) ) -RRB- cord-347946-i6kx3n6m 128 58 with with IN cord-347946-i6kx3n6m 128 59 the the DT cord-347946-i6kx3n6m 128 60 increased increase VBN cord-347946-i6kx3n6m 128 61 population population NN cord-347946-i6kx3n6m 128 62 density density NN cord-347946-i6kx3n6m 128 63 that that WDT cord-347946-i6kx3n6m 128 64 became become VBD cord-347946-i6kx3n6m 128 65 the the DT cord-347946-i6kx3n6m 128 66 norm norm NN cord-347946-i6kx3n6m 128 67 after after IN cord-347946-i6kx3n6m 128 68 the the DT cord-347946-i6kx3n6m 128 69 development development NN cord-347946-i6kx3n6m 128 70 of of IN cord-347946-i6kx3n6m 128 71 agriculture agriculture NN cord-347946-i6kx3n6m 128 72 in in IN cord-347946-i6kx3n6m 128 73 the the DT cord-347946-i6kx3n6m 128 74 first first JJ cord-347946-i6kx3n6m 128 75 epidemiological epidemiological JJ cord-347946-i6kx3n6m 128 76 transition transition NN cord-347946-i6kx3n6m 128 77 . . . cord-347946-i6kx3n6m 129 1 If if IN cord-347946-i6kx3n6m 129 2 we -PRON- PRP cord-347946-i6kx3n6m 129 3 assume assume VBP cord-347946-i6kx3n6m 129 4 that that IN cord-347946-i6kx3n6m 129 5 a a DT cord-347946-i6kx3n6m 129 6 chronic chronic JJ cord-347946-i6kx3n6m 129 7 inflammatory inflammatory JJ cord-347946-i6kx3n6m 129 8 response response NN cord-347946-i6kx3n6m 129 9 is be VBZ cord-347946-i6kx3n6m 129 10 the the DT cord-347946-i6kx3n6m 129 11 most most RBS cord-347946-i6kx3n6m 129 12 common common JJ cord-347946-i6kx3n6m 129 13 immune immune NN cord-347946-i6kx3n6m 129 14 profile profile NN cord-347946-i6kx3n6m 129 15 associated associate VBN cord-347946-i6kx3n6m 129 16 with with IN cord-347946-i6kx3n6m 129 17 MDD MDD NNP cord-347946-i6kx3n6m 129 18 , , , cord-347946-i6kx3n6m 129 19 then then RB cord-347946-i6kx3n6m 129 20 PATHOS pathos NN cord-347946-i6kx3n6m 129 21 - - HYPH cord-347946-i6kx3n6m 129 22 D D NNP cord-347946-i6kx3n6m 129 23 predicts predict VBZ cord-347946-i6kx3n6m 129 24 that that IN cord-347946-i6kx3n6m 129 25 this this DT cord-347946-i6kx3n6m 129 26 association association NN cord-347946-i6kx3n6m 129 27 should should MD cord-347946-i6kx3n6m 129 28 be be VB cord-347946-i6kx3n6m 129 29 ancient ancient JJ cord-347946-i6kx3n6m 129 30 , , , cord-347946-i6kx3n6m 129 31 because because IN cord-347946-i6kx3n6m 129 32 it -PRON- PRP cord-347946-i6kx3n6m 129 33 is be VBZ cord-347946-i6kx3n6m 129 34 this this DT cord-347946-i6kx3n6m 129 35 immune immune JJ cord-347946-i6kx3n6m 129 36 response response NN cord-347946-i6kx3n6m 129 37 and and CC cord-347946-i6kx3n6m 129 38 its -PRON- PRP$ cord-347946-i6kx3n6m 129 39 associated associate VBN cord-347946-i6kx3n6m 129 40 depressive depressive JJ cord-347946-i6kx3n6m 129 41 symptoms symptom NNS cord-347946-i6kx3n6m 129 42 that that WDT cord-347946-i6kx3n6m 129 43 enhanced enhance VBD cord-347946-i6kx3n6m 129 44 survival survival NN cord-347946-i6kx3n6m 129 45 and and CC cord-347946-i6kx3n6m 129 46 reproduction reproduction NN cord-347946-i6kx3n6m 129 47 via via IN cord-347946-i6kx3n6m 129 48 reduced reduced JJ cord-347946-i6kx3n6m 129 49 pathogen pathogen NN cord-347946-i6kx3n6m 129 50 - - HYPH cord-347946-i6kx3n6m 129 51 related relate VBN cord-347946-i6kx3n6m 129 52 mortality mortality NN cord-347946-i6kx3n6m 129 53 . . . cord-347946-i6kx3n6m 130 1 Strong strong JJ cord-347946-i6kx3n6m 130 2 evidence evidence NN cord-347946-i6kx3n6m 130 3 for for IN cord-347946-i6kx3n6m 130 4 this this DT cord-347946-i6kx3n6m 130 5 comes come VBZ cord-347946-i6kx3n6m 130 6 from from IN cord-347946-i6kx3n6m 130 7 innumerable innumerable JJ cord-347946-i6kx3n6m 130 8 studies study NNS cord-347946-i6kx3n6m 130 9 in in IN cord-347946-i6kx3n6m 130 10 mice mouse NNS cord-347946-i6kx3n6m 130 11 and and CC cord-347946-i6kx3n6m 130 12 rats rat NNS cord-347946-i6kx3n6m 130 13 showing show VBG cord-347946-i6kx3n6m 130 14 that that IN cord-347946-i6kx3n6m 130 15 inflammatory inflammatory JJ cord-347946-i6kx3n6m 130 16 cytokines cytokine NNS cord-347946-i6kx3n6m 130 17 and and CC cord-347946-i6kx3n6m 130 18 their -PRON- PRP$ cord-347946-i6kx3n6m 130 19 stimulators stimulator NNS cord-347946-i6kx3n6m 130 20 induce induce VBP cord-347946-i6kx3n6m 130 21 depressive depressive JJ cord-347946-i6kx3n6m 130 22 and and CC cord-347946-i6kx3n6m 130 23 anxiety anxiety NN cord-347946-i6kx3n6m 130 24 - - HYPH cord-347946-i6kx3n6m 130 25 like like JJ cord-347946-i6kx3n6m 130 26 behavior behavior NN cord-347946-i6kx3n6m 130 27 ( ( -LRB- cord-347946-i6kx3n6m 130 28 Dantzer Dantzer NNP cord-347946-i6kx3n6m 130 29 et et FW cord-347946-i6kx3n6m 130 30 al al NNP cord-347946-i6kx3n6m 130 31 , , , cord-347946-i6kx3n6m 130 32 2008a 2008a CD cord-347946-i6kx3n6m 130 33 ) ) -RRB- cord-347946-i6kx3n6m 130 34 , , , cord-347946-i6kx3n6m 130 35 as as RB cord-347946-i6kx3n6m 130 36 well well RB cord-347946-i6kx3n6m 130 37 as as IN cord-347946-i6kx3n6m 130 38 studies study NNS cord-347946-i6kx3n6m 130 39 indicating indicate VBG cord-347946-i6kx3n6m 130 40 that that IN cord-347946-i6kx3n6m 130 41 even even RB cord-347946-i6kx3n6m 130 42 when when WRB cord-347946-i6kx3n6m 130 43 induced induce VBN cord-347946-i6kx3n6m 130 44 by by IN cord-347946-i6kx3n6m 130 45 psychological psychological JJ cord-347946-i6kx3n6m 130 46 stress stress NN cord-347946-i6kx3n6m 130 47 , , , cord-347946-i6kx3n6m 130 48 these these DT cord-347946-i6kx3n6m 130 49 behavioral behavioral JJ cord-347946-i6kx3n6m 130 50 responses response NNS cord-347946-i6kx3n6m 130 51 are be VBP cord-347946-i6kx3n6m 130 52 dependent dependent JJ cord-347946-i6kx3n6m 130 53 upon upon IN cord-347946-i6kx3n6m 130 54 cytokine cytokine NN cord-347946-i6kx3n6m 130 55 activation activation NN cord-347946-i6kx3n6m 130 56 - - : cord-347946-i6kx3n6m 130 57 especially especially RB cord-347946-i6kx3n6m 130 58 the the DT cord-347946-i6kx3n6m 130 59 induction induction NN cord-347946-i6kx3n6m 130 60 of of IN cord-347946-i6kx3n6m 130 61 IL-1-β IL-1-β NNP cord-347946-i6kx3n6m 130 62 in in IN cord-347946-i6kx3n6m 130 63 the the DT cord-347946-i6kx3n6m 130 64 CNS CNS NNP cord-347946-i6kx3n6m 131 1 ( ( -LRB- cord-347946-i6kx3n6m 131 2 Goshen Goshen NNP cord-347946-i6kx3n6m 131 3 and and CC cord-347946-i6kx3n6m 131 4 Yirmiya Yirmiya NNP cord-347946-i6kx3n6m 131 5 , , , cord-347946-i6kx3n6m 131 6 2009 2009 CD cord-347946-i6kx3n6m 131 7 ) ) -RRB- cord-347946-i6kx3n6m 131 8 . . . cord-347946-i6kx3n6m 132 1 The the DT cord-347946-i6kx3n6m 132 2 fact fact NN cord-347946-i6kx3n6m 132 3 that that IN cord-347946-i6kx3n6m 132 4 primate primate JJ cord-347946-i6kx3n6m 132 5 and and CC cord-347946-i6kx3n6m 132 6 rodent rodent NN cord-347946-i6kx3n6m 132 7 lineages lineage NNS cord-347946-i6kx3n6m 132 8 separated separate VBD cord-347946-i6kx3n6m 132 9 from from IN cord-347946-i6kx3n6m 132 10 each each DT cord-347946-i6kx3n6m 132 11 other other JJ cord-347946-i6kx3n6m 132 12 in in IN cord-347946-i6kx3n6m 132 13 the the DT cord-347946-i6kx3n6m 132 14 time time NN cord-347946-i6kx3n6m 132 15 of of IN cord-347946-i6kx3n6m 132 16 the the DT cord-347946-i6kx3n6m 132 17 dinosaurs dinosaur NNS cord-347946-i6kx3n6m 132 18 strongly strongly RB cord-347946-i6kx3n6m 132 19 suggests suggest VBZ cord-347946-i6kx3n6m 132 20 that that IN cord-347946-i6kx3n6m 132 21 the the DT cord-347946-i6kx3n6m 132 22 rudiments rudiment NNS cord-347946-i6kx3n6m 132 23 of of IN cord-347946-i6kx3n6m 132 24 the the DT cord-347946-i6kx3n6m 132 25 immune immune JJ cord-347946-i6kx3n6m 132 26 - - HYPH cord-347946-i6kx3n6m 132 27 depression depression NN cord-347946-i6kx3n6m 132 28 link link NN cord-347946-i6kx3n6m 132 29 were be VBD cord-347946-i6kx3n6m 132 30 laid lay VBN cord-347946-i6kx3n6m 132 31 down down RP cord-347946-i6kx3n6m 132 32 early early RB cord-347946-i6kx3n6m 132 33 in in IN cord-347946-i6kx3n6m 132 34 mammalian mammalian JJ cord-347946-i6kx3n6m 132 35 evolution evolution NN cord-347946-i6kx3n6m 132 36 , , , cord-347946-i6kx3n6m 132 37 if if IN cord-347946-i6kx3n6m 132 38 not not RB cord-347946-i6kx3n6m 132 39 earlier early RBR cord-347946-i6kx3n6m 132 40 . . . cord-347946-i6kx3n6m 133 1 However however RB cord-347946-i6kx3n6m 133 2 , , , cord-347946-i6kx3n6m 133 3 not not RB cord-347946-i6kx3n6m 133 4 all all DT cord-347946-i6kx3n6m 133 5 data datum NNS cord-347946-i6kx3n6m 133 6 support support VBP cord-347946-i6kx3n6m 133 7 an an DT cord-347946-i6kx3n6m 133 8 ancient ancient JJ cord-347946-i6kx3n6m 133 9 or or CC cord-347946-i6kx3n6m 133 10 universal universal JJ cord-347946-i6kx3n6m 133 11 link link NN cord-347946-i6kx3n6m 133 12 between between IN cord-347946-i6kx3n6m 133 13 inflammation inflammation NN cord-347946-i6kx3n6m 133 14 and and CC cord-347946-i6kx3n6m 133 15 depression depression NN cord-347946-i6kx3n6m 133 16 , , , cord-347946-i6kx3n6m 133 17 nor nor CC cord-347946-i6kx3n6m 133 18 is be VBZ cord-347946-i6kx3n6m 133 19 PATHOS pathos NN cord-347946-i6kx3n6m 133 20 - - HYPH cord-347946-i6kx3n6m 133 21 D D NNP cord-347946-i6kx3n6m 133 22 the the DT cord-347946-i6kx3n6m 133 23 only only JJ cord-347946-i6kx3n6m 133 24 evolutionary evolutionary JJ cord-347946-i6kx3n6m 133 25 theory theory NN cord-347946-i6kx3n6m 133 26 that that WDT cord-347946-i6kx3n6m 133 27 might may MD cord-347946-i6kx3n6m 133 28 account account VB cord-347946-i6kx3n6m 133 29 for for IN cord-347946-i6kx3n6m 133 30 such such PDT cord-347946-i6kx3n6m 133 31 a a DT cord-347946-i6kx3n6m 133 32 link link NN cord-347946-i6kx3n6m 133 33 if if IN cord-347946-i6kx3n6m 133 34 it -PRON- PRP cord-347946-i6kx3n6m 133 35 in in IN cord-347946-i6kx3n6m 133 36 fact fact NN cord-347946-i6kx3n6m 133 37 exists exist VBZ cord-347946-i6kx3n6m 133 38 . . . cord-347946-i6kx3n6m 134 1 Indeed indeed RB cord-347946-i6kx3n6m 134 2 , , , cord-347946-i6kx3n6m 134 3 it -PRON- PRP cord-347946-i6kx3n6m 134 4 is be VBZ cord-347946-i6kx3n6m 134 5 increasingly increasingly RB cord-347946-i6kx3n6m 134 6 clear clear JJ cord-347946-i6kx3n6m 134 7 that that IN cord-347946-i6kx3n6m 134 8 numerous numerous JJ cord-347946-i6kx3n6m 134 9 conditions condition NNS cord-347946-i6kx3n6m 134 10 in in IN cord-347946-i6kx3n6m 134 11 the the DT cord-347946-i6kx3n6m 134 12 modern modern JJ cord-347946-i6kx3n6m 134 13 world world NN cord-347946-i6kx3n6m 134 14 have have VBP cord-347946-i6kx3n6m 134 15 dysregulated dysregulate VBN cord-347946-i6kx3n6m 134 16 immune immune JJ cord-347946-i6kx3n6m 134 17 functioning function VBG cord-347946-i6kx3n6m 134 18 in in IN cord-347946-i6kx3n6m 134 19 ways way NNS cord-347946-i6kx3n6m 134 20 that that WDT cord-347946-i6kx3n6m 134 21 promote promote VBP cord-347946-i6kx3n6m 134 22 autoimmunity autoimmunity NN cord-347946-i6kx3n6m 134 23 and and CC cord-347946-i6kx3n6m 134 24 chronic chronic JJ cord-347946-i6kx3n6m 134 25 inflammation inflammation NN cord-347946-i6kx3n6m 134 26 , , , cord-347946-i6kx3n6m 134 27 while while IN cord-347946-i6kx3n6m 134 28 simultaneously simultaneously RB cord-347946-i6kx3n6m 134 29 reducing reduce VBG cord-347946-i6kx3n6m 134 30 any any DT cord-347946-i6kx3n6m 134 31 adaptive adaptive JJ cord-347946-i6kx3n6m 134 32 advantage advantage NN cord-347946-i6kx3n6m 134 33 that that WDT cord-347946-i6kx3n6m 134 34 might may MD cord-347946-i6kx3n6m 134 35 be be VB cord-347946-i6kx3n6m 134 36 inherent inherent JJ cord-347946-i6kx3n6m 134 37 in in IN cord-347946-i6kx3n6m 134 38 either either CC cord-347946-i6kx3n6m 134 39 the the DT cord-347946-i6kx3n6m 134 40 inflammatory inflammatory JJ cord-347946-i6kx3n6m 134 41 response response NN cord-347946-i6kx3n6m 134 42 or or CC cord-347946-i6kx3n6m 134 43 MDD MDD NNP cord-347946-i6kx3n6m 134 44 ( ( -LRB- cord-347946-i6kx3n6m 134 45 Raison Raison NNP cord-347946-i6kx3n6m 134 46 et et NNP cord-347946-i6kx3n6m 134 47 al al NNP cord-347946-i6kx3n6m 134 48 , , , cord-347946-i6kx3n6m 134 49 2010c 2010c CD cord-347946-i6kx3n6m 134 50 ) ) -RRB- cord-347946-i6kx3n6m 134 51 . . . cord-347946-i6kx3n6m 135 1 This this DT cord-347946-i6kx3n6m 135 2 scenario scenario NN cord-347946-i6kx3n6m 135 3 opens open VBZ cord-347946-i6kx3n6m 135 4 the the DT cord-347946-i6kx3n6m 135 5 possibility possibility NN cord-347946-i6kx3n6m 135 6 that that IN cord-347946-i6kx3n6m 135 7 the the DT cord-347946-i6kx3n6m 135 8 association association NN cord-347946-i6kx3n6m 135 9 between between IN cord-347946-i6kx3n6m 135 10 inflammation inflammation NN cord-347946-i6kx3n6m 135 11 and and CC cord-347946-i6kx3n6m 135 12 depression depression NN cord-347946-i6kx3n6m 135 13 is be VBZ cord-347946-i6kx3n6m 135 14 a a DT cord-347946-i6kx3n6m 135 15 non non JJ cord-347946-i6kx3n6m 135 16 - - JJ cord-347946-i6kx3n6m 135 17 adaptive adaptive JJ cord-347946-i6kx3n6m 135 18 by by IN cord-347946-i6kx3n6m 135 19 - - HYPH cord-347946-i6kx3n6m 135 20 product product NN cord-347946-i6kx3n6m 135 21 of of IN cord-347946-i6kx3n6m 135 22 first first JJ cord-347946-i6kx3n6m 135 23 world world NN cord-347946-i6kx3n6m 135 24 environmental environmental JJ cord-347946-i6kx3n6m 135 25 and and CC cord-347946-i6kx3n6m 135 26 social social JJ cord-347946-i6kx3n6m 135 27 conditions condition NNS cord-347946-i6kx3n6m 135 28 , , , cord-347946-i6kx3n6m 135 29 rather rather RB cord-347946-i6kx3n6m 135 30 than than IN cord-347946-i6kx3n6m 135 31 something something NN cord-347946-i6kx3n6m 135 32 inherent inherent JJ cord-347946-i6kx3n6m 135 33 in in IN cord-347946-i6kx3n6m 135 34 either either CC cord-347946-i6kx3n6m 135 35 our -PRON- PRP$ cord-347946-i6kx3n6m 135 36 genetic genetic JJ cord-347946-i6kx3n6m 135 37 or or CC cord-347946-i6kx3n6m 135 38 behavioral behavioral JJ cord-347946-i6kx3n6m 135 39 make make NN cord-347946-i6kx3n6m 135 40 - - HYPH cord-347946-i6kx3n6m 135 41 up up NN cord-347946-i6kx3n6m 135 42 . . . cord-347946-i6kx3n6m 136 1 Said say VBD cord-347946-i6kx3n6m 136 2 differently differently RB cord-347946-i6kx3n6m 136 3 , , , cord-347946-i6kx3n6m 136 4 the the DT cord-347946-i6kx3n6m 136 5 link link NN cord-347946-i6kx3n6m 136 6 between between IN cord-347946-i6kx3n6m 136 7 chronic chronic JJ cord-347946-i6kx3n6m 136 8 inflammation inflammation NN cord-347946-i6kx3n6m 136 9 and and CC cord-347946-i6kx3n6m 136 10 MDD MDD NNP cord-347946-i6kx3n6m 136 11 may may MD cord-347946-i6kx3n6m 136 12 not not RB cord-347946-i6kx3n6m 136 13 reflect reflect VB cord-347946-i6kx3n6m 136 14 an an DT cord-347946-i6kx3n6m 136 15 evolved evolved JJ cord-347946-i6kx3n6m 136 16 adaption adaption NN cord-347946-i6kx3n6m 136 17 , , , cord-347946-i6kx3n6m 136 18 but but CC cord-347946-i6kx3n6m 136 19 rather rather RB cord-347946-i6kx3n6m 136 20 represents represent VBZ cord-347946-i6kx3n6m 136 21 an an DT cord-347946-i6kx3n6m 136 22 example example NN cord-347946-i6kx3n6m 136 23 of of IN cord-347946-i6kx3n6m 136 24 non non JJ cord-347946-i6kx3n6m 136 25 - - JJ cord-347946-i6kx3n6m 136 26 adaptive adaptive JJ cord-347946-i6kx3n6m 136 27 environmental environmental JJ cord-347946-i6kx3n6m 136 28 mismatch mismatch NN cord-347946-i6kx3n6m 136 29 , , , cord-347946-i6kx3n6m 136 30 defined define VBN cord-347946-i6kx3n6m 136 31 as as IN cord-347946-i6kx3n6m 136 32 a a DT cord-347946-i6kx3n6m 136 33 state state NN cord-347946-i6kx3n6m 136 34 of of IN cord-347946-i6kx3n6m 136 35 disequilibrium disequilibrium NN cord-347946-i6kx3n6m 136 36 whereby whereby WRB cord-347946-i6kx3n6m 136 37 a a DT cord-347946-i6kx3n6m 136 38 trait trait NN cord-347946-i6kx3n6m 136 39 that that WDT cord-347946-i6kx3n6m 136 40 enhanced enhance VBD cord-347946-i6kx3n6m 136 41 reproductive reproductive JJ cord-347946-i6kx3n6m 136 42 fitness fitness NN cord-347946-i6kx3n6m 136 43 in in IN cord-347946-i6kx3n6m 136 44 the the DT cord-347946-i6kx3n6m 136 45 environment environment NN cord-347946-i6kx3n6m 136 46 in in IN cord-347946-i6kx3n6m 136 47 which which WDT cord-347946-i6kx3n6m 136 48 it -PRON- PRP cord-347946-i6kx3n6m 136 49 evolved evolve VBD cord-347946-i6kx3n6m 136 50 becomes become VBZ cord-347946-i6kx3n6m 136 51 maladaptive maladaptive JJ cord-347946-i6kx3n6m 136 52 in in IN cord-347946-i6kx3n6m 136 53 another another DT cord-347946-i6kx3n6m 136 54 environment environment NN cord-347946-i6kx3n6m 136 55 . . . cord-347946-i6kx3n6m 137 1 Of of IN cord-347946-i6kx3n6m 137 2 all all PDT cord-347946-i6kx3n6m 137 3 the the DT cord-347946-i6kx3n6m 137 4 modern modern JJ cord-347946-i6kx3n6m 137 5 environmental environmental JJ cord-347946-i6kx3n6m 137 6 conditions condition NNS cord-347946-i6kx3n6m 137 7 that that WDT cord-347946-i6kx3n6m 137 8 have have VBP cord-347946-i6kx3n6m 137 9 altered alter VBN cord-347946-i6kx3n6m 137 10 associations association NNS cord-347946-i6kx3n6m 137 11 between between IN cord-347946-i6kx3n6m 137 12 immune immune JJ cord-347946-i6kx3n6m 137 13 function function NN cord-347946-i6kx3n6m 137 14 and and CC cord-347946-i6kx3n6m 137 15 behavior behavior NN cord-347946-i6kx3n6m 137 16 , , , cord-347946-i6kx3n6m 137 17 none none NN cord-347946-i6kx3n6m 137 18 has have VBZ cord-347946-i6kx3n6m 137 19 received receive VBN cord-347946-i6kx3n6m 137 20 more more JJR cord-347946-i6kx3n6m 137 21 attention attention NN cord-347946-i6kx3n6m 137 22 than than IN cord-347946-i6kx3n6m 137 23 our -PRON- PRP$ cord-347946-i6kx3n6m 137 24 changed change VBN cord-347946-i6kx3n6m 137 25 relationships relationship NNS cord-347946-i6kx3n6m 137 26 with with IN cord-347946-i6kx3n6m 137 27 a a DT cord-347946-i6kx3n6m 137 28 huge huge JJ cord-347946-i6kx3n6m 137 29 range range NN cord-347946-i6kx3n6m 137 30 of of IN cord-347946-i6kx3n6m 137 31 microorganisms microorganism NNS cord-347946-i6kx3n6m 137 32 that that WDT cord-347946-i6kx3n6m 137 33 were be VBD cord-347946-i6kx3n6m 137 34 ubiquitous ubiquitous JJ cord-347946-i6kx3n6m 137 35 in in IN cord-347946-i6kx3n6m 137 36 the the DT cord-347946-i6kx3n6m 137 37 EEA EEA NNP cord-347946-i6kx3n6m 137 38 , , , cord-347946-i6kx3n6m 137 39 but but CC cord-347946-i6kx3n6m 137 40 that that DT cord-347946-i6kx3n6m 137 41 are be VBP cord-347946-i6kx3n6m 137 42 largely largely RB cord-347946-i6kx3n6m 137 43 missing miss VBG cord-347946-i6kx3n6m 137 44 from from IN cord-347946-i6kx3n6m 137 45 the the DT cord-347946-i6kx3n6m 137 46 industrialized industrialize VBN cord-347946-i6kx3n6m 137 47 world world NN cord-347946-i6kx3n6m 137 48 . . . cord-347946-i6kx3n6m 138 1 Unlike unlike IN cord-347946-i6kx3n6m 138 2 potentially potentially RB cord-347946-i6kx3n6m 138 3 lethal lethal JJ cord-347946-i6kx3n6m 138 4 pathogens pathogen NNS cord-347946-i6kx3n6m 138 5 , , , cord-347946-i6kx3n6m 138 6 most most JJS cord-347946-i6kx3n6m 138 7 of of IN cord-347946-i6kx3n6m 138 8 which which WDT cord-347946-i6kx3n6m 138 9 produced produce VBD cord-347946-i6kx3n6m 138 10 either either CC cord-347946-i6kx3n6m 138 11 immunity immunity NN cord-347946-i6kx3n6m 138 12 or or CC cord-347946-i6kx3n6m 138 13 death death NN cord-347946-i6kx3n6m 138 14 , , , cord-347946-i6kx3n6m 138 15 many many JJ cord-347946-i6kx3n6m 138 16 of of IN cord-347946-i6kx3n6m 138 17 the the DT cord-347946-i6kx3n6m 138 18 now now RB cord-347946-i6kx3n6m 138 19 - - HYPH cord-347946-i6kx3n6m 138 20 absent absent JJ cord-347946-i6kx3n6m 138 21 organisms organism NNS cord-347946-i6kx3n6m 138 22 were be VBD cord-347946-i6kx3n6m 138 23 best well RBS cord-347946-i6kx3n6m 138 24 dealt deal VBN cord-347946-i6kx3n6m 138 25 with with IN cord-347946-i6kx3n6m 138 26 via via IN cord-347946-i6kx3n6m 138 27 the the DT cord-347946-i6kx3n6m 138 28 development development NN cord-347946-i6kx3n6m 138 29 of of IN cord-347946-i6kx3n6m 138 30 immune immune JJ cord-347946-i6kx3n6m 138 31 tolerance tolerance NN cord-347946-i6kx3n6m 138 32 , , , cord-347946-i6kx3n6m 138 33 either either CC cord-347946-i6kx3n6m 138 34 because because IN cord-347946-i6kx3n6m 138 35 the the DT cord-347946-i6kx3n6m 138 36 organisms organism NNS cord-347946-i6kx3n6m 138 37 were be VBD cord-347946-i6kx3n6m 138 38 beneficial beneficial JJ cord-347946-i6kx3n6m 138 39 ( ( -LRB- cord-347946-i6kx3n6m 138 40 eg eg IN cord-347946-i6kx3n6m 138 41 , , , cord-347946-i6kx3n6m 138 42 the the DT cord-347946-i6kx3n6m 138 43 microbiota microbiota NN cord-347946-i6kx3n6m 138 44 ) ) -RRB- cord-347946-i6kx3n6m 138 45 , , , cord-347946-i6kx3n6m 138 46 harmless harmless JJ cord-347946-i6kx3n6m 138 47 ( ( -LRB- cord-347946-i6kx3n6m 138 48 eg eg IN cord-347946-i6kx3n6m 138 49 , , , cord-347946-i6kx3n6m 138 50 many many JJ cord-347946-i6kx3n6m 138 51 environmental environmental JJ cord-347946-i6kx3n6m 138 52 organisms organism NNS cord-347946-i6kx3n6m 138 53 ) ) -RRB- cord-347946-i6kx3n6m 138 54 , , , cord-347946-i6kx3n6m 138 55 infectious infectious JJ cord-347946-i6kx3n6m 138 56 but but CC cord-347946-i6kx3n6m 138 57 not not RB cord-347946-i6kx3n6m 138 58 lethal lethal JJ cord-347946-i6kx3n6m 138 59 ( ( -LRB- cord-347946-i6kx3n6m 138 60 eg eg UH cord-347946-i6kx3n6m 138 61 , , , cord-347946-i6kx3n6m 138 62 hepatitis hepatitis VB cord-347946-i6kx3n6m 138 63 A a DT cord-347946-i6kx3n6m 138 64 virus virus NN cord-347946-i6kx3n6m 138 65 ) ) -RRB- cord-347946-i6kx3n6m 138 66 or or CC cord-347946-i6kx3n6m 138 67 potentially potentially RB cord-347946-i6kx3n6m 138 68 harmful harmful JJ cord-347946-i6kx3n6m 138 69 but but CC cord-347946-i6kx3n6m 138 70 not not RB cord-347946-i6kx3n6m 138 71 easily easily RB cord-347946-i6kx3n6m 138 72 cleared clear VBN cord-347946-i6kx3n6m 138 73 by by IN cord-347946-i6kx3n6m 138 74 the the DT cord-347946-i6kx3n6m 138 75 immune immune JJ cord-347946-i6kx3n6m 138 76 system system NN cord-347946-i6kx3n6m 138 77 without without IN cord-347946-i6kx3n6m 138 78 excessive excessive JJ cord-347946-i6kx3n6m 138 79 tissue tissue NN cord-347946-i6kx3n6m 138 80 damage damage NN cord-347946-i6kx3n6m 138 81 ( ( -LRB- cord-347946-i6kx3n6m 138 82 eg eg IN cord-347946-i6kx3n6m 138 83 , , , cord-347946-i6kx3n6m 138 84 many many JJ cord-347946-i6kx3n6m 138 85 helminths helminth NNS cord-347946-i6kx3n6m 138 86 ) ) -RRB- cord-347946-i6kx3n6m 138 87 . . . cord-347946-i6kx3n6m 139 1 The the DT cord-347946-i6kx3n6m 139 2 central central JJ cord-347946-i6kx3n6m 139 3 insight insight NN cord-347946-i6kx3n6m 139 4 of of IN cord-347946-i6kx3n6m 139 5 recent recent JJ cord-347946-i6kx3n6m 139 6 iterations iteration NNS cord-347946-i6kx3n6m 139 7 of of IN cord-347946-i6kx3n6m 139 8 the the DT cord-347946-i6kx3n6m 139 9 ' ' `` cord-347946-i6kx3n6m 139 10 hygiene hygiene NN cord-347946-i6kx3n6m 139 11 hypothesis hypothesis NN cord-347946-i6kx3n6m 139 12 ' ' '' cord-347946-i6kx3n6m 139 13 ( ( -LRB- cord-347946-i6kx3n6m 139 14 such such JJ cord-347946-i6kx3n6m 139 15 as as IN cord-347946-i6kx3n6m 139 16 the the DT cord-347946-i6kx3n6m 139 17 ' ' `` cord-347946-i6kx3n6m 139 18 Old Old NNP cord-347946-i6kx3n6m 139 19 Friends Friends NNPS cord-347946-i6kx3n6m 139 20 ' ' POS cord-347946-i6kx3n6m 139 21 Hypothesis Hypothesis NNP cord-347946-i6kx3n6m 139 22 of of IN cord-347946-i6kx3n6m 139 23 Rook Rook NNP cord-347946-i6kx3n6m 139 24 ) ) -RRB- cord-347946-i6kx3n6m 139 25 is be VBZ cord-347946-i6kx3n6m 139 26 that that IN cord-347946-i6kx3n6m 139 27 because because IN cord-347946-i6kx3n6m 139 28 the the DT cord-347946-i6kx3n6m 139 29 immune immune JJ cord-347946-i6kx3n6m 139 30 system system NN cord-347946-i6kx3n6m 139 31 had have VBD cord-347946-i6kx3n6m 139 32 to to TO cord-347946-i6kx3n6m 139 33 learn learn VB cord-347946-i6kx3n6m 139 34 to to TO cord-347946-i6kx3n6m 139 35 tolerate tolerate VB cord-347946-i6kx3n6m 139 36 these these DT cord-347946-i6kx3n6m 139 37 organisms organism NNS cord-347946-i6kx3n6m 139 38 ( ( -LRB- cord-347946-i6kx3n6m 139 39 as as IN cord-347946-i6kx3n6m 139 40 opposed oppose VBN cord-347946-i6kx3n6m 139 41 to to IN cord-347946-i6kx3n6m 139 42 clearing clear VBG cord-347946-i6kx3n6m 139 43 them -PRON- PRP cord-347946-i6kx3n6m 139 44 from from IN cord-347946-i6kx3n6m 139 45 the the DT cord-347946-i6kx3n6m 139 46 body body NN cord-347946-i6kx3n6m 139 47 ) ) -RRB- cord-347946-i6kx3n6m 139 48 , , , cord-347946-i6kx3n6m 139 49 they -PRON- PRP cord-347946-i6kx3n6m 139 50 became become VBD cord-347946-i6kx3n6m 139 51 ' ' `` cord-347946-i6kx3n6m 139 52 teachers teacher NNS cord-347946-i6kx3n6m 139 53 of of IN cord-347946-i6kx3n6m 139 54 tolerance tolerance NN cord-347946-i6kx3n6m 139 55 , , , cord-347946-i6kx3n6m 139 56 ' ' '' cord-347946-i6kx3n6m 139 57 especially especially RB cord-347946-i6kx3n6m 139 58 during during IN cord-347946-i6kx3n6m 139 59 childhood childhood NN cord-347946-i6kx3n6m 139 60 development development NN cord-347946-i6kx3n6m 139 61 when when WRB cord-347946-i6kx3n6m 139 62 their -PRON- PRP$ cord-347946-i6kx3n6m 139 63 absence absence NN cord-347946-i6kx3n6m 139 64 predisposes predispose VBZ cord-347946-i6kx3n6m 139 65 individuals individual NNS cord-347946-i6kx3n6m 139 66 in in IN cord-347946-i6kx3n6m 139 67 industrialized industrialize VBN cord-347946-i6kx3n6m 139 68 societies society NNS cord-347946-i6kx3n6m 139 69 to to TO cord-347946-i6kx3n6m 139 70 develop develop VB cord-347946-i6kx3n6m 139 71 a a DT cord-347946-i6kx3n6m 139 72 host host NN cord-347946-i6kx3n6m 139 73 of of IN cord-347946-i6kx3n6m 139 74 allergic allergic JJ cord-347946-i6kx3n6m 139 75 , , , cord-347946-i6kx3n6m 139 76 asthmatic asthmatic JJ cord-347946-i6kx3n6m 139 77 , , , cord-347946-i6kx3n6m 139 78 autoimmune autoimmune JJ cord-347946-i6kx3n6m 139 79 , , , cord-347946-i6kx3n6m 139 80 and and CC cord-347946-i6kx3n6m 139 81 psychiatric psychiatric JJ cord-347946-i6kx3n6m 139 82 pathologies pathology NNS cord-347946-i6kx3n6m 140 1 ( ( -LRB- cord-347946-i6kx3n6m 140 2 Raison Raison NNP cord-347946-i6kx3n6m 140 3 et et NNP cord-347946-i6kx3n6m 140 4 al al NNP cord-347946-i6kx3n6m 140 5 , , , cord-347946-i6kx3n6m 140 6 2010c 2010c CD cord-347946-i6kx3n6m 140 7 ) ) -RRB- cord-347946-i6kx3n6m 140 8 . . . cord-347946-i6kx3n6m 141 1 In in IN cord-347946-i6kx3n6m 141 2 a a DT cord-347946-i6kx3n6m 141 3 way way NN cord-347946-i6kx3n6m 141 4 that that WDT cord-347946-i6kx3n6m 141 5 seems seem VBZ cord-347946-i6kx3n6m 141 6 more more RBR cord-347946-i6kx3n6m 141 7 than than IN cord-347946-i6kx3n6m 141 8 metaphorical metaphorical JJ cord-347946-i6kx3n6m 141 9 , , , cord-347946-i6kx3n6m 141 10 this this DT cord-347946-i6kx3n6m 141 11 notion notion NN cord-347946-i6kx3n6m 141 12 points point VBZ cord-347946-i6kx3n6m 141 13 toward toward IN cord-347946-i6kx3n6m 141 14 another another DT cord-347946-i6kx3n6m 141 15 way way NN cord-347946-i6kx3n6m 141 16 that that DT cord-347946-i6kx3n6m 141 17 depression depression NN cord-347946-i6kx3n6m 141 18 may may MD cord-347946-i6kx3n6m 141 19 be be VB cord-347946-i6kx3n6m 141 20 about about IN cord-347946-i6kx3n6m 141 21 relationships relationship NNS cord-347946-i6kx3n6m 141 22 . . . cord-347946-i6kx3n6m 142 1 We -PRON- PRP cord-347946-i6kx3n6m 142 2 need need VBP cord-347946-i6kx3n6m 142 3 to to TO cord-347946-i6kx3n6m 142 4 look look VB cord-347946-i6kx3n6m 142 5 no no RB cord-347946-i6kx3n6m 142 6 further far RBR cord-347946-i6kx3n6m 142 7 than than IN cord-347946-i6kx3n6m 142 8 the the DT cord-347946-i6kx3n6m 142 9 impact impact NN cord-347946-i6kx3n6m 142 10 of of IN cord-347946-i6kx3n6m 142 11 bereavement bereavement NN cord-347946-i6kx3n6m 142 12 on on IN cord-347946-i6kx3n6m 142 13 mood mood NN cord-347946-i6kx3n6m 142 14 or or CC cord-347946-i6kx3n6m 142 15 the the DT cord-347946-i6kx3n6m 142 16 strong strong JJ cord-347946-i6kx3n6m 142 17 association association NN cord-347946-i6kx3n6m 142 18 between between IN cord-347946-i6kx3n6m 142 19 the the DT cord-347946-i6kx3n6m 142 20 death death NN cord-347946-i6kx3n6m 142 21 of of IN cord-347946-i6kx3n6m 142 22 a a DT cord-347946-i6kx3n6m 142 23 parent parent NN cord-347946-i6kx3n6m 142 24 in in IN cord-347946-i6kx3n6m 142 25 childhood childhood NN cord-347946-i6kx3n6m 142 26 and and CC cord-347946-i6kx3n6m 142 27 the the DT cord-347946-i6kx3n6m 142 28 development development NN cord-347946-i6kx3n6m 142 29 of of IN cord-347946-i6kx3n6m 142 30 MDD MDD NNP cord-347946-i6kx3n6m 142 31 in in IN cord-347946-i6kx3n6m 142 32 adulthood adulthood NN cord-347946-i6kx3n6m 142 33 to to TO cord-347946-i6kx3n6m 142 34 see see VB cord-347946-i6kx3n6m 142 35 that that IN cord-347946-i6kx3n6m 142 36 human human JJ cord-347946-i6kx3n6m 142 37 relationships relationship NNS cord-347946-i6kx3n6m 142 38 characterized characterize VBN cord-347946-i6kx3n6m 142 39 by by IN cord-347946-i6kx3n6m 142 40 loss loss NN cord-347946-i6kx3n6m 142 41 can can MD cord-347946-i6kx3n6m 142 42 be be VB cord-347946-i6kx3n6m 142 43 profoundly profoundly RB cord-347946-i6kx3n6m 142 44 depressogenic depressogenic JJ cord-347946-i6kx3n6m 142 45 ( ( -LRB- cord-347946-i6kx3n6m 142 46 Berg Berg NNP cord-347946-i6kx3n6m 142 47 et et NNP cord-347946-i6kx3n6m 142 48 al al NNP cord-347946-i6kx3n6m 142 49 , , , cord-347946-i6kx3n6m 142 50 2016 2016 CD cord-347946-i6kx3n6m 142 51 ) ) -RRB- cord-347946-i6kx3n6m 142 52 . . . cord-347946-i6kx3n6m 143 1 Increasing increase VBG cord-347946-i6kx3n6m 143 2 evidence evidence NN cord-347946-i6kx3n6m 143 3 suggests suggest VBZ cord-347946-i6kx3n6m 143 4 the the DT cord-347946-i6kx3n6m 143 5 same same JJ cord-347946-i6kx3n6m 143 6 is be VBZ cord-347946-i6kx3n6m 143 7 true true JJ cord-347946-i6kx3n6m 143 8 of of IN cord-347946-i6kx3n6m 143 9 our -PRON- PRP$ cord-347946-i6kx3n6m 143 10 relationships relationship NNS cord-347946-i6kx3n6m 143 11 with with IN cord-347946-i6kx3n6m 143 12 the the DT cord-347946-i6kx3n6m 143 13 microbial microbial JJ cord-347946-i6kx3n6m 143 14 world world NN cord-347946-i6kx3n6m 143 15 . . . cord-347946-i6kx3n6m 144 1 Via via IN cord-347946-i6kx3n6m 144 2 dysregulated dysregulated JJ cord-347946-i6kx3n6m 144 3 inflammatory inflammatory JJ cord-347946-i6kx3n6m 144 4 activity activity NN cord-347946-i6kx3n6m 144 5 , , , cord-347946-i6kx3n6m 144 6 our -PRON- PRP$ cord-347946-i6kx3n6m 144 7 moods mood NNS cord-347946-i6kx3n6m 144 8 are be VBP cord-347946-i6kx3n6m 144 9 haunted haunt VBN cord-347946-i6kx3n6m 144 10 by by IN cord-347946-i6kx3n6m 144 11 the the DT cord-347946-i6kx3n6m 144 12 loss loss NN cord-347946-i6kx3n6m 144 13 of of IN cord-347946-i6kx3n6m 144 14 ' ' `` cord-347946-i6kx3n6m 144 15 old old JJ cord-347946-i6kx3n6m 144 16 friend friend NN cord-347946-i6kx3n6m 144 17 ' ' '' cord-347946-i6kx3n6m 144 18 organisms organism NNS cord-347946-i6kx3n6m 144 19 of of IN cord-347946-i6kx3n6m 144 20 which which WDT cord-347946-i6kx3n6m 144 21 most most JJS cord-347946-i6kx3n6m 144 22 of of IN cord-347946-i6kx3n6m 144 23 us -PRON- PRP cord-347946-i6kx3n6m 144 24 have have VBP cord-347946-i6kx3n6m 144 25 no no DT cord-347946-i6kx3n6m 144 26 conscious conscious JJ cord-347946-i6kx3n6m 144 27 knowledge knowledge NN cord-347946-i6kx3n6m 144 28 . . . cord-347946-i6kx3n6m 145 1 Again again RB cord-347946-i6kx3n6m 145 2 , , , cord-347946-i6kx3n6m 145 3 like like IN cord-347946-i6kx3n6m 145 4 our -PRON- PRP$ cord-347946-i6kx3n6m 145 5 relationships relationship NNS cord-347946-i6kx3n6m 145 6 with with IN cord-347946-i6kx3n6m 145 7 other other JJ cord-347946-i6kx3n6m 145 8 humans human NNS cord-347946-i6kx3n6m 145 9 , , , cord-347946-i6kx3n6m 145 10 our -PRON- PRP$ cord-347946-i6kx3n6m 145 11 relationships relationship NNS cord-347946-i6kx3n6m 145 12 with with IN cord-347946-i6kx3n6m 145 13 bacteria bacteria NNS cord-347946-i6kx3n6m 145 14 , , , cord-347946-i6kx3n6m 145 15 viruses virus NNS cord-347946-i6kx3n6m 145 16 , , , cord-347946-i6kx3n6m 145 17 and and CC cord-347946-i6kx3n6m 145 18 parasites parasite NNS cord-347946-i6kx3n6m 145 19 can can MD cord-347946-i6kx3n6m 145 20 be be VB cord-347946-i6kx3n6m 145 21 understood understand VBN cord-347946-i6kx3n6m 145 22 as as IN cord-347946-i6kx3n6m 145 23 comprising comprise VBG cord-347946-i6kx3n6m 145 24 various various JJ cord-347946-i6kx3n6m 145 25 degrees degree NNS cord-347946-i6kx3n6m 145 26 of of IN cord-347946-i6kx3n6m 145 27 competition competition NN cord-347946-i6kx3n6m 145 28 and and CC cord-347946-i6kx3n6m 145 29 cooperation cooperation NN cord-347946-i6kx3n6m 145 30 / / SYM cord-347946-i6kx3n6m 145 31 collaboration collaboration NN cord-347946-i6kx3n6m 145 32 . . . cord-347946-i6kx3n6m 146 1 PATHOS pathos NN cord-347946-i6kx3n6m 146 2 - - HYPH cord-347946-i6kx3n6m 146 3 D D NNP cord-347946-i6kx3n6m 146 4 suggests suggest VBZ cord-347946-i6kx3n6m 146 5 that that IN cord-347946-i6kx3n6m 146 6 the the DT cord-347946-i6kx3n6m 146 7 link link NN cord-347946-i6kx3n6m 146 8 between between IN cord-347946-i6kx3n6m 146 9 depression depression NN cord-347946-i6kx3n6m 146 10 and and CC cord-347946-i6kx3n6m 146 11 immune immune JJ cord-347946-i6kx3n6m 146 12 activation activation NN cord-347946-i6kx3n6m 146 13 primarily primarily RB cord-347946-i6kx3n6m 146 14 reflects reflect VBZ cord-347946-i6kx3n6m 146 15 the the DT cord-347946-i6kx3n6m 146 16 competitive competitive JJ cord-347946-i6kx3n6m 146 17 element element NN cord-347946-i6kx3n6m 146 18 in in IN cord-347946-i6kx3n6m 146 19 these these DT cord-347946-i6kx3n6m 146 20 relationships relationship NNS cord-347946-i6kx3n6m 146 21 . . . cord-347946-i6kx3n6m 147 1 The the DT cord-347946-i6kx3n6m 147 2 evolutionary evolutionary JJ cord-347946-i6kx3n6m 147 3 mismatch mismatch NN cord-347946-i6kx3n6m 147 4 model model NN cord-347946-i6kx3n6m 147 5 suggests suggest VBZ cord-347946-i6kx3n6m 147 6 the the DT cord-347946-i6kx3n6m 147 7 opposite opposite NN cord-347946-i6kx3n6m 147 8 : : : cord-347946-i6kx3n6m 147 9 that that IN cord-347946-i6kx3n6m 147 10 the the DT cord-347946-i6kx3n6m 147 11 link link NN cord-347946-i6kx3n6m 147 12 between between IN cord-347946-i6kx3n6m 147 13 depression depression NN cord-347946-i6kx3n6m 147 14 and and CC cord-347946-i6kx3n6m 147 15 immune immune JJ cord-347946-i6kx3n6m 147 16 activation activation NN cord-347946-i6kx3n6m 147 17 reflects reflect VBZ cord-347946-i6kx3n6m 147 18 the the DT cord-347946-i6kx3n6m 147 19 failure failure NN cord-347946-i6kx3n6m 147 20 of of IN cord-347946-i6kx3n6m 147 21 the the DT cord-347946-i6kx3n6m 147 22 modern modern JJ cord-347946-i6kx3n6m 147 23 world world NN cord-347946-i6kx3n6m 147 24 to to TO cord-347946-i6kx3n6m 147 25 honor honor VB cord-347946-i6kx3n6m 147 26 many many JJ cord-347946-i6kx3n6m 147 27 ancient ancient JJ cord-347946-i6kx3n6m 147 28 and and CC cord-347946-i6kx3n6m 147 29 mutually mutually RB cord-347946-i6kx3n6m 147 30 beneficial beneficial JJ cord-347946-i6kx3n6m 147 31 collaborations collaboration NNS cord-347946-i6kx3n6m 147 32 . . . cord-347946-i6kx3n6m 148 1 So so RB cord-347946-i6kx3n6m 148 2 , , , cord-347946-i6kx3n6m 148 3 can can MD cord-347946-i6kx3n6m 148 4 available available JJ cord-347946-i6kx3n6m 148 5 data datum NNS cord-347946-i6kx3n6m 148 6 help help VBP cord-347946-i6kx3n6m 148 7 us -PRON- PRP cord-347946-i6kx3n6m 148 8 determine determine VB cord-347946-i6kx3n6m 148 9 which which WDT cord-347946-i6kx3n6m 148 10 theory theory NN cord-347946-i6kx3n6m 148 11 is be VBZ cord-347946-i6kx3n6m 148 12 better well RBR cord-347946-i6kx3n6m 148 13 supported support VBN cord-347946-i6kx3n6m 148 14 ? ? . cord-347946-i6kx3n6m 149 1 To to IN cord-347946-i6kx3n6m 149 2 our -PRON- PRP$ cord-347946-i6kx3n6m 149 3 minds mind NNS cord-347946-i6kx3n6m 149 4 , , , cord-347946-i6kx3n6m 149 5 the the DT cord-347946-i6kx3n6m 149 6 strongest strong JJS cord-347946-i6kx3n6m 149 7 data datum NNS cord-347946-i6kx3n6m 149 8 that that WDT cord-347946-i6kx3n6m 149 9 support support VBP cord-347946-i6kx3n6m 149 10 evolutionary evolutionary JJ cord-347946-i6kx3n6m 149 11 mismatch mismatch NN cord-347946-i6kx3n6m 149 12 , , , cord-347946-i6kx3n6m 149 13 while while IN cord-347946-i6kx3n6m 149 14 simultaneously simultaneously RB cord-347946-i6kx3n6m 149 15 arguing argue VBG cord-347946-i6kx3n6m 149 16 against against IN cord-347946-i6kx3n6m 149 17 PATHOS pathos NN cord-347946-i6kx3n6m 149 18 - - HYPH cord-347946-i6kx3n6m 149 19 D D NNP cord-347946-i6kx3n6m 149 20 , , , cord-347946-i6kx3n6m 149 21 come come VBN cord-347946-i6kx3n6m 149 22 from from IN cord-347946-i6kx3n6m 149 23 the the DT cord-347946-i6kx3n6m 149 24 ground ground NN cord-347946-i6kx3n6m 149 25 - - HYPH cord-347946-i6kx3n6m 149 26 breaking break VBG cord-347946-i6kx3n6m 149 27 work work NN cord-347946-i6kx3n6m 149 28 of of IN cord-347946-i6kx3n6m 149 29 McDade McDade NNP cord-347946-i6kx3n6m 149 30 and and CC cord-347946-i6kx3n6m 149 31 colleagues colleague NNS cord-347946-i6kx3n6m 149 32 who who WP cord-347946-i6kx3n6m 149 33 have have VBP cord-347946-i6kx3n6m 149 34 examined examine VBN cord-347946-i6kx3n6m 149 35 associations association NNS cord-347946-i6kx3n6m 149 36 between between IN cord-347946-i6kx3n6m 149 37 stress stress NN cord-347946-i6kx3n6m 149 38 , , , cord-347946-i6kx3n6m 149 39 mood mood NN cord-347946-i6kx3n6m 149 40 and and CC cord-347946-i6kx3n6m 149 41 inflammation inflammation NN cord-347946-i6kx3n6m 149 42 in in IN cord-347946-i6kx3n6m 149 43 non non JJ cord-347946-i6kx3n6m 149 44 - - JJ cord-347946-i6kx3n6m 149 45 industrialized industrialize VBN cord-347946-i6kx3n6m 149 46 environments environment NNS cord-347946-i6kx3n6m 149 47 . . . cord-347946-i6kx3n6m 150 1 Working work VBG cord-347946-i6kx3n6m 150 2 in in IN cord-347946-i6kx3n6m 150 3 the the DT cord-347946-i6kx3n6m 150 4 Philippines Philippines NNPS cord-347946-i6kx3n6m 150 5 and and CC cord-347946-i6kx3n6m 150 6 lowland lowland JJ cord-347946-i6kx3n6m 150 7 Ecuador Ecuador NNP cord-347946-i6kx3n6m 150 8 , , , cord-347946-i6kx3n6m 150 9 they -PRON- PRP cord-347946-i6kx3n6m 150 10 have have VBP cord-347946-i6kx3n6m 150 11 shown show VBN cord-347946-i6kx3n6m 150 12 that that IN cord-347946-i6kx3n6m 150 13 patterns pattern NNS cord-347946-i6kx3n6m 150 14 of of IN cord-347946-i6kx3n6m 150 15 inflammation inflammation NN cord-347946-i6kx3n6m 150 16 observed observe VBN cord-347946-i6kx3n6m 150 17 in in IN cord-347946-i6kx3n6m 150 18 the the DT cord-347946-i6kx3n6m 150 19 West West NNP cord-347946-i6kx3n6m 150 20 do do VBP cord-347946-i6kx3n6m 150 21 not not RB cord-347946-i6kx3n6m 150 22 necessarily necessarily RB cord-347946-i6kx3n6m 150 23 translate translate VB cord-347946-i6kx3n6m 150 24 to to IN cord-347946-i6kx3n6m 150 25 less less RBR cord-347946-i6kx3n6m 150 26 - - HYPH cord-347946-i6kx3n6m 150 27 developed develop VBN cord-347946-i6kx3n6m 150 28 environments environment NNS cord-347946-i6kx3n6m 150 29 with with IN cord-347946-i6kx3n6m 150 30 significantly significantly RB cord-347946-i6kx3n6m 150 31 higher high JJR cord-347946-i6kx3n6m 150 32 pathogen pathogen NN cord-347946-i6kx3n6m 150 33 exposure exposure NN cord-347946-i6kx3n6m 150 34 and and CC cord-347946-i6kx3n6m 150 35 infectious infectious JJ cord-347946-i6kx3n6m 150 36 mortality mortality NN cord-347946-i6kx3n6m 150 37 . . . cord-347946-i6kx3n6m 151 1 In in IN cord-347946-i6kx3n6m 151 2 industrialized industrialize VBN cord-347946-i6kx3n6m 151 3 contexts context NNS cord-347946-i6kx3n6m 151 4 , , , cord-347946-i6kx3n6m 151 5 the the DT cord-347946-i6kx3n6m 151 6 concentrations concentration NNS cord-347946-i6kx3n6m 151 7 of of IN cord-347946-i6kx3n6m 151 8 peripheral peripheral JJ cord-347946-i6kx3n6m 151 9 inflammatory inflammatory JJ cord-347946-i6kx3n6m 151 10 biomarkers biomarker NNS cord-347946-i6kx3n6m 151 11 show show VBP cord-347946-i6kx3n6m 151 12 significant significant JJ cord-347946-i6kx3n6m 151 13 intra intra JJ cord-347946-i6kx3n6m 151 14 - - JJ cord-347946-i6kx3n6m 151 15 individual individual JJ cord-347946-i6kx3n6m 151 16 stability stability NN cord-347946-i6kx3n6m 151 17 , , , cord-347946-i6kx3n6m 151 18 with with IN cord-347946-i6kx3n6m 151 19 some some DT cord-347946-i6kx3n6m 151 20 individuals individual NNS cord-347946-i6kx3n6m 151 21 demonstrating demonstrate VBG cord-347946-i6kx3n6m 151 22 chronically chronically RB cord-347946-i6kx3n6m 151 23 elevated elevate VBN cord-347946-i6kx3n6m 151 24 levels level NNS cord-347946-i6kx3n6m 151 25 of of IN cord-347946-i6kx3n6m 151 26 these these DT cord-347946-i6kx3n6m 151 27 biomarkers biomarker NNS cord-347946-i6kx3n6m 152 1 ( ( -LRB- cord-347946-i6kx3n6m 152 2 Macy Macy NNP cord-347946-i6kx3n6m 152 3 et et NNP cord-347946-i6kx3n6m 152 4 al al NNP cord-347946-i6kx3n6m 152 5 , , , cord-347946-i6kx3n6m 152 6 1997 1997 CD cord-347946-i6kx3n6m 152 7 ; ; : cord-347946-i6kx3n6m 152 8 Ockene Ockene NNP cord-347946-i6kx3n6m 152 9 et et NNP cord-347946-i6kx3n6m 152 10 al al NNP cord-347946-i6kx3n6m 152 11 , , , cord-347946-i6kx3n6m 152 12 2001 2001 CD cord-347946-i6kx3n6m 152 13 ) ) -RRB- cord-347946-i6kx3n6m 152 14 . . . cord-347946-i6kx3n6m 153 1 Moreover moreover RB cord-347946-i6kx3n6m 153 2 , , , cord-347946-i6kx3n6m 153 3 factors factor NNS cord-347946-i6kx3n6m 153 4 other other JJ cord-347946-i6kx3n6m 153 5 than than IN cord-347946-i6kx3n6m 153 6 pathogen pathogen NN cord-347946-i6kx3n6m 153 7 exposure exposure NN cord-347946-i6kx3n6m 153 8 ( ( -LRB- cord-347946-i6kx3n6m 153 9 especially especially RB cord-347946-i6kx3n6m 153 10 obesity obesity NN cord-347946-i6kx3n6m 153 11 ) ) -RRB- cord-347946-i6kx3n6m 153 12 have have VBP cord-347946-i6kx3n6m 153 13 been be VBN cord-347946-i6kx3n6m 153 14 repeatedly repeatedly RB cord-347946-i6kx3n6m 153 15 shown show VBN cord-347946-i6kx3n6m 153 16 to to TO cord-347946-i6kx3n6m 153 17 upregulate upregulate VB cord-347946-i6kx3n6m 153 18 inflammation inflammation NN cord-347946-i6kx3n6m 153 19 . . . cord-347946-i6kx3n6m 154 1 McDade McDade NNP cord-347946-i6kx3n6m 154 2 et et NNP cord-347946-i6kx3n6m 154 3 al al NNP cord-347946-i6kx3n6m 154 4 , , , cord-347946-i6kx3n6m 154 5 ( ( -LRB- cord-347946-i6kx3n6m 154 6 2009 2009 CD cord-347946-i6kx3n6m 154 7 ) ) -RRB- cord-347946-i6kx3n6m 154 8 found find VBD cord-347946-i6kx3n6m 154 9 that that IN cord-347946-i6kx3n6m 154 10 neither neither DT cord-347946-i6kx3n6m 154 11 of of IN cord-347946-i6kx3n6m 154 12 these these DT cord-347946-i6kx3n6m 154 13 pertain pertain VBP cord-347946-i6kx3n6m 154 14 in in IN cord-347946-i6kx3n6m 154 15 more more JJR cord-347946-i6kx3n6m 154 16 traditional traditional JJ cord-347946-i6kx3n6m 154 17 societies society NNS cord-347946-i6kx3n6m 154 18 . . . cord-347946-i6kx3n6m 155 1 In in IN cord-347946-i6kx3n6m 155 2 the the DT cord-347946-i6kx3n6m 155 3 Philippines Philippines NNP cord-347946-i6kx3n6m 155 4 levels level NNS cord-347946-i6kx3n6m 155 5 of of IN cord-347946-i6kx3n6m 155 6 CRP CRP NNP cord-347946-i6kx3n6m 155 7 were be VBD cord-347946-i6kx3n6m 155 8 significantly significantly RB cord-347946-i6kx3n6m 155 9 lower low JJR cord-347946-i6kx3n6m 155 10 , , , cord-347946-i6kx3n6m 155 11 and and CC cord-347946-i6kx3n6m 155 12 levels level NNS cord-347946-i6kx3n6m 155 13 of of IN cord-347946-i6kx3n6m 155 14 the the DT cord-347946-i6kx3n6m 155 15 anti anti JJ cord-347946-i6kx3n6m 155 16 - - JJ cord-347946-i6kx3n6m 155 17 inflammatory inflammatory JJ cord-347946-i6kx3n6m 155 18 cytokine cytokine NN cord-347946-i6kx3n6m 155 19 IL-10 IL-10 NNP cord-347946-i6kx3n6m 155 20 significantly significantly RB cord-347946-i6kx3n6m 155 21 higher higher RBR cord-347946-i6kx3n6m 155 22 , , , cord-347946-i6kx3n6m 155 23 than than IN cord-347946-i6kx3n6m 155 24 are be VBP cord-347946-i6kx3n6m 155 25 typically typically RB cord-347946-i6kx3n6m 155 26 observed observe VBN cord-347946-i6kx3n6m 155 27 in in IN cord-347946-i6kx3n6m 155 28 Western western JJ cord-347946-i6kx3n6m 155 29 contexts context NNS cord-347946-i6kx3n6m 155 30 , , , cord-347946-i6kx3n6m 155 31 and and CC cord-347946-i6kx3n6m 155 32 these these DT cord-347946-i6kx3n6m 155 33 associations association NNS cord-347946-i6kx3n6m 155 34 were be VBD cord-347946-i6kx3n6m 155 35 not not RB cord-347946-i6kx3n6m 155 36 accounted account VBN cord-347946-i6kx3n6m 155 37 for for IN cord-347946-i6kx3n6m 155 38 by by IN cord-347946-i6kx3n6m 155 39 differences difference NNS cord-347946-i6kx3n6m 155 40 in in IN cord-347946-i6kx3n6m 155 41 body body NN cord-347946-i6kx3n6m 155 42 mass mass NN cord-347946-i6kx3n6m 155 43 index index NN cord-347946-i6kx3n6m 155 44 between between IN cord-347946-i6kx3n6m 155 45 the the DT cord-347946-i6kx3n6m 155 46 populations population NNS cord-347946-i6kx3n6m 156 1 ( ( -LRB- cord-347946-i6kx3n6m 156 2 McDade McDade NNP cord-347946-i6kx3n6m 156 3 et et NNP cord-347946-i6kx3n6m 156 4 al al NNP cord-347946-i6kx3n6m 156 5 , , , cord-347946-i6kx3n6m 156 6 2009 2009 CD cord-347946-i6kx3n6m 156 7 ) ) -RRB- cord-347946-i6kx3n6m 156 8 . . . cord-347946-i6kx3n6m 157 1 In in IN cord-347946-i6kx3n6m 157 2 lowland lowland JJ cord-347946-i6kx3n6m 157 3 Ecuador Ecuador NNP cord-347946-i6kx3n6m 157 4 among among IN cord-347946-i6kx3n6m 157 5 the the DT cord-347946-i6kx3n6m 157 6 indigenous indigenous JJ cord-347946-i6kx3n6m 157 7 Shuar Shuar NNP cord-347946-i6kx3n6m 157 8 people people NNS cord-347946-i6kx3n6m 157 9 , , , cord-347946-i6kx3n6m 157 10 levels level NNS cord-347946-i6kx3n6m 157 11 of of IN cord-347946-i6kx3n6m 157 12 CRP CRP NNP cord-347946-i6kx3n6m 157 13 were be VBD cord-347946-i6kx3n6m 157 14 found find VBN cord-347946-i6kx3n6m 157 15 to to TO cord-347946-i6kx3n6m 157 16 vary vary VB cord-347946-i6kx3n6m 157 17 widely widely RB cord-347946-i6kx3n6m 157 18 within within IN cord-347946-i6kx3n6m 157 19 the the DT cord-347946-i6kx3n6m 157 20 same same JJ cord-347946-i6kx3n6m 157 21 individuals individual NNS cord-347946-i6kx3n6m 157 22 , , , cord-347946-i6kx3n6m 157 23 showing show VBG cord-347946-i6kx3n6m 157 24 a a DT cord-347946-i6kx3n6m 157 25 pattern pattern NN cord-347946-i6kx3n6m 157 26 of of IN cord-347946-i6kx3n6m 157 27 rapid rapid JJ cord-347946-i6kx3n6m 157 28 rise rise NN cord-347946-i6kx3n6m 157 29 to to IN cord-347946-i6kx3n6m 157 30 high high JJ cord-347946-i6kx3n6m 157 31 levels level NNS cord-347946-i6kx3n6m 157 32 in in IN cord-347946-i6kx3n6m 157 33 response response NN cord-347946-i6kx3n6m 157 34 to to IN cord-347946-i6kx3n6m 157 35 acute acute JJ cord-347946-i6kx3n6m 157 36 infection infection NN cord-347946-i6kx3n6m 157 37 and and CC cord-347946-i6kx3n6m 157 38 then then RB cord-347946-i6kx3n6m 157 39 dropping drop VBG cord-347946-i6kx3n6m 157 40 to to IN cord-347946-i6kx3n6m 157 41 often often RB cord-347946-i6kx3n6m 157 42 undetectable undetectable JJ cord-347946-i6kx3n6m 157 43 levels level NNS cord-347946-i6kx3n6m 157 44 upon upon IN cord-347946-i6kx3n6m 157 45 infection infection NN cord-347946-i6kx3n6m 157 46 resolution resolution NN cord-347946-i6kx3n6m 157 47 ( ( -LRB- cord-347946-i6kx3n6m 157 48 McDade McDade NNP cord-347946-i6kx3n6m 157 49 et et NNP cord-347946-i6kx3n6m 157 50 al al NNP cord-347946-i6kx3n6m 157 51 , , , cord-347946-i6kx3n6m 157 52 2012b 2012b CD cord-347946-i6kx3n6m 157 53 ) ) -RRB- cord-347946-i6kx3n6m 157 54 . . . cord-347946-i6kx3n6m 158 1 An an DT cord-347946-i6kx3n6m 158 2 even even RB cord-347946-i6kx3n6m 158 3 more more RBR cord-347946-i6kx3n6m 158 4 direct direct JJ cord-347946-i6kx3n6m 158 5 challenge challenge NN cord-347946-i6kx3n6m 158 6 to to IN cord-347946-i6kx3n6m 158 7 PATHOS pathos NN cord-347946-i6kx3n6m 158 8 - - HYPH cord-347946-i6kx3n6m 158 9 D d JJ cord-347946-i6kx3n6m 158 10 predictions prediction NNS cord-347946-i6kx3n6m 158 11 came come VBD cord-347946-i6kx3n6m 158 12 from from IN cord-347946-i6kx3n6m 158 13 findings finding NNS cord-347946-i6kx3n6m 158 14 that that IN cord-347946-i6kx3n6m 158 15 depression depression NN cord-347946-i6kx3n6m 158 16 was be VBD cord-347946-i6kx3n6m 158 17 not not RB cord-347946-i6kx3n6m 158 18 associated associate VBN cord-347946-i6kx3n6m 158 19 with with IN cord-347946-i6kx3n6m 158 20 elevated elevated JJ cord-347946-i6kx3n6m 158 21 CRP crp NN cord-347946-i6kx3n6m 158 22 in in IN cord-347946-i6kx3n6m 158 23 the the DT cord-347946-i6kx3n6m 158 24 Philippines Philippines NNPS cord-347946-i6kx3n6m 158 25 and and CC cord-347946-i6kx3n6m 158 26 that that IN cord-347946-i6kx3n6m 158 27 associations association NNS cord-347946-i6kx3n6m 158 28 between between IN cord-347946-i6kx3n6m 158 29 both both CC cord-347946-i6kx3n6m 158 30 current current JJ cord-347946-i6kx3n6m 158 31 and and CC cord-347946-i6kx3n6m 158 32 childhood childhood NN cord-347946-i6kx3n6m 158 33 stressors stressor NNS cord-347946-i6kx3n6m 158 34 ( ( -LRB- cord-347946-i6kx3n6m 158 35 ie ie RB cord-347946-i6kx3n6m 158 36 , , , cord-347946-i6kx3n6m 158 37 death death NN cord-347946-i6kx3n6m 158 38 of of IN cord-347946-i6kx3n6m 158 39 a a DT cord-347946-i6kx3n6m 158 40 parent parent NN cord-347946-i6kx3n6m 158 41 ) ) -RRB- cord-347946-i6kx3n6m 158 42 and and CC cord-347946-i6kx3n6m 158 43 inflammation inflammation NN cord-347946-i6kx3n6m 158 44 were be VBD cord-347946-i6kx3n6m 158 45 only only RB cord-347946-i6kx3n6m 158 46 apparent apparent JJ cord-347946-i6kx3n6m 158 47 in in IN cord-347946-i6kx3n6m 158 48 the the DT cord-347946-i6kx3n6m 158 49 sub sub NN cord-347946-i6kx3n6m 158 50 - - JJ cord-347946-i6kx3n6m 158 51 population population NN cord-347946-i6kx3n6m 158 52 in in IN cord-347946-i6kx3n6m 158 53 the the DT cord-347946-i6kx3n6m 158 54 Cebu Cebu NNP cord-347946-i6kx3n6m 158 55 region region NN cord-347946-i6kx3n6m 158 56 that that WDT cord-347946-i6kx3n6m 158 57 had have VBD cord-347946-i6kx3n6m 158 58 been be VBN cord-347946-i6kx3n6m 158 59 raised raise VBN cord-347946-i6kx3n6m 158 60 in in IN cord-347946-i6kx3n6m 158 61 more more RBR cord-347946-i6kx3n6m 158 62 hygienic hygienic JJ cord-347946-i6kx3n6m 158 63 environments environment NNS cord-347946-i6kx3n6m 158 64 ( ( -LRB- cord-347946-i6kx3n6m 158 65 McDade McDade NNP cord-347946-i6kx3n6m 158 66 et et NNP cord-347946-i6kx3n6m 158 67 al al NNP cord-347946-i6kx3n6m 158 68 , , , cord-347946-i6kx3n6m 158 69 2012a 2012a CD cord-347946-i6kx3n6m 158 70 ) ) -RRB- cord-347946-i6kx3n6m 158 71 . . . cord-347946-i6kx3n6m 159 1 Individuals individual NNS cord-347946-i6kx3n6m 159 2 with with IN cord-347946-i6kx3n6m 159 3 high high JJ cord-347946-i6kx3n6m 159 4 levels level NNS cord-347946-i6kx3n6m 159 5 of of IN cord-347946-i6kx3n6m 159 6 microbial microbial JJ cord-347946-i6kx3n6m 159 7 exposure exposure NN cord-347946-i6kx3n6m 159 8 in in IN cord-347946-i6kx3n6m 159 9 infancy infancy NN cord-347946-i6kx3n6m 159 10 showed show VBD cord-347946-i6kx3n6m 159 11 no no DT cord-347946-i6kx3n6m 159 12 such such JJ cord-347946-i6kx3n6m 159 13 associations association NNS cord-347946-i6kx3n6m 159 14 . . . cord-347946-i6kx3n6m 160 1 Taken take VBN cord-347946-i6kx3n6m 160 2 together together RB cord-347946-i6kx3n6m 160 3 , , , cord-347946-i6kx3n6m 160 4 these these DT cord-347946-i6kx3n6m 160 5 data datum NNS cord-347946-i6kx3n6m 160 6 suggest suggest VBP cord-347946-i6kx3n6m 160 7 that that IN cord-347946-i6kx3n6m 160 8 high high JJ cord-347946-i6kx3n6m 160 9 microbial microbial JJ cord-347946-i6kx3n6m 160 10 exposure exposure NN cord-347946-i6kx3n6m 160 11 early early RB cord-347946-i6kx3n6m 160 12 in in IN cord-347946-i6kx3n6m 160 13 life life NN cord-347946-i6kx3n6m 160 14 - - , cord-347946-i6kx3n6m 160 15 such such JJ cord-347946-i6kx3n6m 160 16 as as IN cord-347946-i6kx3n6m 160 17 would would MD cord-347946-i6kx3n6m 160 18 have have VB cord-347946-i6kx3n6m 160 19 been be VBN cord-347946-i6kx3n6m 160 20 normative normative JJ cord-347946-i6kx3n6m 160 21 across across IN cord-347946-i6kx3n6m 160 22 human human JJ cord-347946-i6kx3n6m 160 23 evolution evolution NN cord-347946-i6kx3n6m 160 24 - - : cord-347946-i6kx3n6m 160 25 may may MD cord-347946-i6kx3n6m 160 26 hone hone VB cord-347946-i6kx3n6m 160 27 the the DT cord-347946-i6kx3n6m 160 28 immune immune JJ cord-347946-i6kx3n6m 160 29 response response NN cord-347946-i6kx3n6m 160 30 to to TO cord-347946-i6kx3n6m 160 31 be be VB cord-347946-i6kx3n6m 160 32 more more RBR cord-347946-i6kx3n6m 160 33 specific specific JJ cord-347946-i6kx3n6m 160 34 for for IN cord-347946-i6kx3n6m 160 35 pathogen pathogen NN cord-347946-i6kx3n6m 160 36 exposure exposure NN cord-347946-i6kx3n6m 160 37 and and CC cord-347946-i6kx3n6m 160 38 less less RBR cord-347946-i6kx3n6m 160 39 generalized generalized JJ cord-347946-i6kx3n6m 160 40 to to IN cord-347946-i6kx3n6m 160 41 the the DT cord-347946-i6kx3n6m 160 42 types type NNS cord-347946-i6kx3n6m 160 43 of of IN cord-347946-i6kx3n6m 160 44 psychosocial psychosocial JJ cord-347946-i6kx3n6m 160 45 stress stress NN cord-347946-i6kx3n6m 160 46 that that WDT cord-347946-i6kx3n6m 160 47 so so RB cord-347946-i6kx3n6m 160 48 reliably reliably RB cord-347946-i6kx3n6m 160 49 induce induce VB cord-347946-i6kx3n6m 160 50 depression depression NN cord-347946-i6kx3n6m 160 51 . . . cord-347946-i6kx3n6m 161 1 Under under IN cord-347946-i6kx3n6m 161 2 these these DT cord-347946-i6kx3n6m 161 3 evolutionarily evolutionarily RB cord-347946-i6kx3n6m 161 4 normative normative JJ cord-347946-i6kx3n6m 161 5 environments environment NNS cord-347946-i6kx3n6m 161 6 , , , cord-347946-i6kx3n6m 161 7 the the DT cord-347946-i6kx3n6m 161 8 links link NNS cord-347946-i6kx3n6m 161 9 between between IN cord-347946-i6kx3n6m 161 10 inflammation inflammation NN cord-347946-i6kx3n6m 161 11 and and CC cord-347946-i6kx3n6m 161 12 MDD MDD NNP cord-347946-i6kx3n6m 161 13 that that WDT cord-347946-i6kx3n6m 161 14 are be VBP cord-347946-i6kx3n6m 161 15 so so RB cord-347946-i6kx3n6m 161 16 apparent apparent JJ cord-347946-i6kx3n6m 161 17 in in IN cord-347946-i6kx3n6m 161 18 the the DT cord-347946-i6kx3n6m 161 19 West West NNP cord-347946-i6kx3n6m 161 20 would would MD cord-347946-i6kx3n6m 161 21 not not RB cord-347946-i6kx3n6m 161 22 exist exist VB cord-347946-i6kx3n6m 161 23 . . . cord-347946-i6kx3n6m 162 1 However however RB cord-347946-i6kx3n6m 162 2 , , , cord-347946-i6kx3n6m 162 3 these these DT cord-347946-i6kx3n6m 162 4 findings finding NNS cord-347946-i6kx3n6m 162 5 must must MD cord-347946-i6kx3n6m 162 6 be be VB cord-347946-i6kx3n6m 162 7 balanced balance VBN cord-347946-i6kx3n6m 162 8 against against IN cord-347946-i6kx3n6m 162 9 more more JJR cord-347946-i6kx3n6m 162 10 recent recent JJ cord-347946-i6kx3n6m 162 11 work work NN cord-347946-i6kx3n6m 162 12 conducted conduct VBN cord-347946-i6kx3n6m 162 13 in in IN cord-347946-i6kx3n6m 162 14 the the DT cord-347946-i6kx3n6m 162 15 lowland lowland JJ cord-347946-i6kx3n6m 162 16 jungle jungle NN cord-347946-i6kx3n6m 162 17 of of IN cord-347946-i6kx3n6m 162 18 Bolivia Bolivia NNP cord-347946-i6kx3n6m 162 19 among among IN cord-347946-i6kx3n6m 162 20 the the DT cord-347946-i6kx3n6m 162 21 Tsimane Tsimane NNP cord-347946-i6kx3n6m 162 22 Amerindians Amerindians NNPS cord-347946-i6kx3n6m 162 23 , , , cord-347946-i6kx3n6m 162 24 a a DT cord-347946-i6kx3n6m 162 25 small small JJ cord-347946-i6kx3n6m 162 26 - - HYPH cord-347946-i6kx3n6m 162 27 scale scale NN cord-347946-i6kx3n6m 162 28 society society NN cord-347946-i6kx3n6m 162 29 composed compose VBN cord-347946-i6kx3n6m 162 30 of of IN cord-347946-i6kx3n6m 162 31 lean lean JJ cord-347946-i6kx3n6m 162 32 forager forager NN cord-347946-i6kx3n6m 162 33 - - HYPH cord-347946-i6kx3n6m 162 34 horticulturalists horticulturalist NNS cord-347946-i6kx3n6m 162 35 with with IN cord-347946-i6kx3n6m 162 36 a a DT cord-347946-i6kx3n6m 162 37 short short JJ cord-347946-i6kx3n6m 162 38 average average JJ cord-347946-i6kx3n6m 162 39 lifespan lifespan NN cord-347946-i6kx3n6m 162 40 who who WP cord-347946-i6kx3n6m 162 41 live live VBP cord-347946-i6kx3n6m 162 42 in in IN cord-347946-i6kx3n6m 162 43 a a DT cord-347946-i6kx3n6m 162 44 high high JJ cord-347946-i6kx3n6m 162 45 - - HYPH cord-347946-i6kx3n6m 162 46 pathogen pathogen NN cord-347946-i6kx3n6m 162 47 environment environment NN cord-347946-i6kx3n6m 162 48 and and CC cord-347946-i6kx3n6m 162 49 thus thus RB cord-347946-i6kx3n6m 162 50 have have VBP cord-347946-i6kx3n6m 162 51 significant significant JJ cord-347946-i6kx3n6m 162 52 microbial microbial JJ cord-347946-i6kx3n6m 162 53 priming priming NN cord-347946-i6kx3n6m 162 54 in in IN cord-347946-i6kx3n6m 162 55 infancy infancy NN cord-347946-i6kx3n6m 163 1 ( ( -LRB- cord-347946-i6kx3n6m 163 2 Stieglitz Stieglitz NNP cord-347946-i6kx3n6m 163 3 et et NNP cord-347946-i6kx3n6m 163 4 al al NNP cord-347946-i6kx3n6m 163 5 , , , cord-347946-i6kx3n6m 163 6 2015b 2015b CD cord-347946-i6kx3n6m 163 7 ) ) -RRB- cord-347946-i6kx3n6m 163 8 . . . cord-347946-i6kx3n6m 164 1 In in IN cord-347946-i6kx3n6m 164 2 all all PDT cord-347946-i6kx3n6m 164 3 these these DT cord-347946-i6kx3n6m 164 4 ways way NNS cord-347946-i6kx3n6m 164 5 the the DT cord-347946-i6kx3n6m 164 6 Tsimane Tsimane NNP cord-347946-i6kx3n6m 164 7 represent represent VBP cord-347946-i6kx3n6m 164 8 a a DT cord-347946-i6kx3n6m 164 9 reasonable reasonable JJ cord-347946-i6kx3n6m 164 10 approximation approximation NN cord-347946-i6kx3n6m 164 11 of of IN cord-347946-i6kx3n6m 164 12 environmental environmental JJ cord-347946-i6kx3n6m 164 13 and and CC cord-347946-i6kx3n6m 164 14 social social JJ cord-347946-i6kx3n6m 164 15 conditions condition NNS cord-347946-i6kx3n6m 164 16 prototypically prototypically RB cord-347946-i6kx3n6m 164 17 confronted confront VBN cord-347946-i6kx3n6m 164 18 by by IN cord-347946-i6kx3n6m 164 19 humans human NNS cord-347946-i6kx3n6m 164 20 in in IN cord-347946-i6kx3n6m 164 21 the the DT cord-347946-i6kx3n6m 164 22 EEA EEA NNP cord-347946-i6kx3n6m 164 23 . . . cord-347946-i6kx3n6m 165 1 Working work VBG cord-347946-i6kx3n6m 165 2 among among IN cord-347946-i6kx3n6m 165 3 these these DT cord-347946-i6kx3n6m 165 4 people people NNS cord-347946-i6kx3n6m 165 5 , , , cord-347946-i6kx3n6m 165 6 Stieglitz Stieglitz NNP cord-347946-i6kx3n6m 165 7 et et NNP cord-347946-i6kx3n6m 165 8 al al NNP cord-347946-i6kx3n6m 165 9 . . . cord-347946-i6kx3n6m 166 1 ( ( -LRB- cord-347946-i6kx3n6m 166 2 2015b 2015b CD cord-347946-i6kx3n6m 166 3 ) ) -RRB- cord-347946-i6kx3n6m 166 4 examined examine VBD cord-347946-i6kx3n6m 166 5 whether whether IN cord-347946-i6kx3n6m 166 6 a a DT cord-347946-i6kx3n6m 166 7 syndrome syndrome NN cord-347946-i6kx3n6m 166 8 recognizable recognizable JJ cord-347946-i6kx3n6m 166 9 as as IN cord-347946-i6kx3n6m 166 10 MDD MDD NNP cord-347946-i6kx3n6m 166 11 exists exist VBZ cord-347946-i6kx3n6m 166 12 , , , cord-347946-i6kx3n6m 166 13 and and CC cord-347946-i6kx3n6m 166 14 if if IN cord-347946-i6kx3n6m 166 15 it -PRON- PRP cord-347946-i6kx3n6m 166 16 exists exist VBZ cord-347946-i6kx3n6m 166 17 , , , cord-347946-i6kx3n6m 166 18 whether whether IN cord-347946-i6kx3n6m 166 19 it -PRON- PRP cord-347946-i6kx3n6m 166 20 is be VBZ cord-347946-i6kx3n6m 166 21 associated associate VBN cord-347946-i6kx3n6m 166 22 with with IN cord-347946-i6kx3n6m 166 23 increased increase VBN cord-347946-i6kx3n6m 166 24 inflammatory inflammatory JJ cord-347946-i6kx3n6m 166 25 biomarkers biomarker NNS cord-347946-i6kx3n6m 166 26 . . . cord-347946-i6kx3n6m 167 1 Results result NNS cord-347946-i6kx3n6m 167 2 indicated indicate VBD cord-347946-i6kx3n6m 167 3 that that IN cord-347946-i6kx3n6m 167 4 a a DT cord-347946-i6kx3n6m 167 5 depressive depressive JJ cord-347946-i6kx3n6m 167 6 syndrome syndrome NN cord-347946-i6kx3n6m 167 7 identical identical JJ cord-347946-i6kx3n6m 167 8 to to IN cord-347946-i6kx3n6m 167 9 that that DT cord-347946-i6kx3n6m 167 10 seen see VBN cord-347946-i6kx3n6m 167 11 in in IN cord-347946-i6kx3n6m 167 12 the the DT cord-347946-i6kx3n6m 167 13 industrialized industrialize VBN cord-347946-i6kx3n6m 167 14 world world NN cord-347946-i6kx3n6m 167 15 exists exist VBZ cord-347946-i6kx3n6m 167 16 among among IN cord-347946-i6kx3n6m 167 17 the the DT cord-347946-i6kx3n6m 167 18 Tsimane Tsimane NNP cord-347946-i6kx3n6m 167 19 , , , cord-347946-i6kx3n6m 167 20 and and CC cord-347946-i6kx3n6m 167 21 is be VBZ cord-347946-i6kx3n6m 167 22 associated associate VBN cord-347946-i6kx3n6m 167 23 with with IN cord-347946-i6kx3n6m 167 24 the the DT cord-347946-i6kx3n6m 167 25 same same JJ cord-347946-i6kx3n6m 167 26 risk risk NN cord-347946-i6kx3n6m 167 27 factors factor NNS cord-347946-i6kx3n6m 167 28 that that WDT cord-347946-i6kx3n6m 167 29 have have VBP cord-347946-i6kx3n6m 167 30 been be VBN cord-347946-i6kx3n6m 167 31 observed observe VBN cord-347946-i6kx3n6m 167 32 everywhere everywhere RB cord-347946-i6kx3n6m 167 33 else else RB cord-347946-i6kx3n6m 167 34 in in IN cord-347946-i6kx3n6m 167 35 the the DT cord-347946-i6kx3n6m 167 36 world world NN cord-347946-i6kx3n6m 167 37 : : : cord-347946-i6kx3n6m 167 38 reduced reduce VBN cord-347946-i6kx3n6m 167 39 health health NN cord-347946-i6kx3n6m 167 40 ( ( -LRB- cord-347946-i6kx3n6m 167 41 indexed index VBN cord-347946-i6kx3n6m 167 42 as as IN cord-347946-i6kx3n6m 167 43 functional functional JJ cord-347946-i6kx3n6m 167 44 disability disability NN cord-347946-i6kx3n6m 167 45 ) ) -RRB- cord-347946-i6kx3n6m 167 46 and and CC cord-347946-i6kx3n6m 167 47 psychosocial psychosocial JJ cord-347946-i6kx3n6m 167 48 stress stress NN cord-347946-i6kx3n6m 167 49 ( ( -LRB- cord-347946-i6kx3n6m 167 50 indexed index VBN cord-347946-i6kx3n6m 167 51 by by IN cord-347946-i6kx3n6m 167 52 social social JJ cord-347946-i6kx3n6m 167 53 conflict conflict NN cord-347946-i6kx3n6m 167 54 , , , cord-347946-i6kx3n6m 167 55 especially especially RB cord-347946-i6kx3n6m 167 56 with with IN cord-347946-i6kx3n6m 167 57 non non JJ cord-347946-i6kx3n6m 167 58 - - JJ cord-347946-i6kx3n6m 167 59 kin kin JJ cord-347946-i6kx3n6m 167 60 ; ; : cord-347946-i6kx3n6m 167 61 Stieglitz Stieglitz NNP cord-347946-i6kx3n6m 167 62 et et NNP cord-347946-i6kx3n6m 167 63 al al NNP cord-347946-i6kx3n6m 167 64 , , , cord-347946-i6kx3n6m 167 65 2015a 2015a CD cord-347946-i6kx3n6m 167 66 ) ) -RRB- cord-347946-i6kx3n6m 167 67 . . . cord-347946-i6kx3n6m 168 1 When when WRB cord-347946-i6kx3n6m 168 2 examined examine VBN cord-347946-i6kx3n6m 168 3 as as IN cord-347946-i6kx3n6m 168 4 a a DT cord-347946-i6kx3n6m 168 5 binary binary JJ cord-347946-i6kx3n6m 168 6 construct construct NN cord-347946-i6kx3n6m 168 7 based base VBN cord-347946-i6kx3n6m 168 8 on on IN cord-347946-i6kx3n6m 168 9 a a DT cord-347946-i6kx3n6m 168 10 median median JJ cord-347946-i6kx3n6m 168 11 split split NN cord-347946-i6kx3n6m 168 12 in in IN cord-347946-i6kx3n6m 168 13 symptom symptom NN cord-347946-i6kx3n6m 168 14 scores score NNS cord-347946-i6kx3n6m 168 15 , , , cord-347946-i6kx3n6m 168 16 depression depression NN cord-347946-i6kx3n6m 168 17 was be VBD cord-347946-i6kx3n6m 168 18 also also RB cord-347946-i6kx3n6m 168 19 associated associate VBN cord-347946-i6kx3n6m 168 20 with with IN cord-347946-i6kx3n6m 168 21 significantly significantly RB cord-347946-i6kx3n6m 168 22 increased increase VBN cord-347946-i6kx3n6m 168 23 serum serum NN cord-347946-i6kx3n6m 168 24 concentrations concentration NNS cord-347946-i6kx3n6m 168 25 of of IN cord-347946-i6kx3n6m 168 26 IL-6 IL-6 NNP cord-347946-i6kx3n6m 168 27 , , , cord-347946-i6kx3n6m 168 28 TNF TNF NNP cord-347946-i6kx3n6m 168 29 , , , cord-347946-i6kx3n6m 168 30 and and CC cord-347946-i6kx3n6m 168 31 CRP CRP NNP cord-347946-i6kx3n6m 168 32 but but CC cord-347946-i6kx3n6m 168 33 not not RB cord-347946-i6kx3n6m 168 34 IL-1-β il-1-β XX cord-347946-i6kx3n6m 168 35 ( ( -LRB- cord-347946-i6kx3n6m 168 36 Stieglitz Stieglitz NNP cord-347946-i6kx3n6m 168 37 et et NNP cord-347946-i6kx3n6m 168 38 al al NNP cord-347946-i6kx3n6m 168 39 , , , cord-347946-i6kx3n6m 168 40 2015b 2015b CD cord-347946-i6kx3n6m 168 41 ) ) -RRB- cord-347946-i6kx3n6m 168 42 , , , cord-347946-i6kx3n6m 168 43 replicating replicate VBG cord-347946-i6kx3n6m 168 44 the the DT cord-347946-i6kx3n6m 168 45 overall overall JJ cord-347946-i6kx3n6m 168 46 pattern pattern NN cord-347946-i6kx3n6m 168 47 of of IN cord-347946-i6kx3n6m 168 48 metaanalytic metaanalytic JJ cord-347946-i6kx3n6m 168 49 findings finding NNS cord-347946-i6kx3n6m 168 50 from from IN cord-347946-i6kx3n6m 168 51 studies study NNS cord-347946-i6kx3n6m 168 52 conducted conduct VBN cord-347946-i6kx3n6m 168 53 in in IN cord-347946-i6kx3n6m 168 54 industrialized industrialize VBN cord-347946-i6kx3n6m 168 55 societies society NNS cord-347946-i6kx3n6m 168 56 . . . cord-347946-i6kx3n6m 169 1 These these DT cord-347946-i6kx3n6m 169 2 associations association NNS cord-347946-i6kx3n6m 169 3 remained remain VBD cord-347946-i6kx3n6m 169 4 after after IN cord-347946-i6kx3n6m 169 5 adjustment adjustment NN cord-347946-i6kx3n6m 169 6 for for IN cord-347946-i6kx3n6m 169 7 age age NN cord-347946-i6kx3n6m 169 8 , , , cord-347946-i6kx3n6m 169 9 body body NN cord-347946-i6kx3n6m 169 10 mass mass NN cord-347946-i6kx3n6m 169 11 index index NN cord-347946-i6kx3n6m 169 12 , , , cord-347946-i6kx3n6m 169 13 and and CC cord-347946-i6kx3n6m 169 14 high high JJ cord-347946-i6kx3n6m 169 15 leukocyte leukocyte NN cord-347946-i6kx3n6m 169 16 count count NN cord-347946-i6kx3n6m 169 17 ( ( -LRB- cord-347946-i6kx3n6m 169 18 likely likely RB cord-347946-i6kx3n6m 169 19 indicative indicative JJ cord-347946-i6kx3n6m 169 20 of of IN cord-347946-i6kx3n6m 169 21 current current JJ cord-347946-i6kx3n6m 169 22 infection infection NN cord-347946-i6kx3n6m 169 23 ) ) -RRB- cord-347946-i6kx3n6m 169 24 , , , cord-347946-i6kx3n6m 169 25 and and CC cord-347946-i6kx3n6m 169 26 associations association NNS cord-347946-i6kx3n6m 169 27 were be VBD cord-347946-i6kx3n6m 169 28 observed observe VBN cord-347946-i6kx3n6m 169 29 across across IN cord-347946-i6kx3n6m 169 30 a a DT cord-347946-i6kx3n6m 169 31 wide wide JJ cord-347946-i6kx3n6m 169 32 range range NN cord-347946-i6kx3n6m 169 33 of of IN cord-347946-i6kx3n6m 169 34 depressive depressive JJ cord-347946-i6kx3n6m 169 35 symptoms symptom NNS cord-347946-i6kx3n6m 169 36 . . . cord-347946-i6kx3n6m 170 1 As as IN cord-347946-i6kx3n6m 170 2 our -PRON- PRP$ cord-347946-i6kx3n6m 170 3 discussion discussion NN cord-347946-i6kx3n6m 170 4 of of IN cord-347946-i6kx3n6m 170 5 this this DT cord-347946-i6kx3n6m 170 6 prediction prediction NN cord-347946-i6kx3n6m 170 7 suggests suggest VBZ cord-347946-i6kx3n6m 170 8 , , , cord-347946-i6kx3n6m 170 9 currently currently RB cord-347946-i6kx3n6m 170 10 available available JJ cord-347946-i6kx3n6m 170 11 data datum NNS cord-347946-i6kx3n6m 170 12 provide provide VBP cord-347946-i6kx3n6m 170 13 a a DT cord-347946-i6kx3n6m 170 14 split split JJ cord-347946-i6kx3n6m 170 15 decision decision NN cord-347946-i6kx3n6m 170 16 on on IN cord-347946-i6kx3n6m 170 17 whether whether IN cord-347946-i6kx3n6m 170 18 associations association NNS cord-347946-i6kx3n6m 170 19 between between IN cord-347946-i6kx3n6m 170 20 depression depression NN cord-347946-i6kx3n6m 170 21 and and CC cord-347946-i6kx3n6m 170 22 inflammation inflammation NN cord-347946-i6kx3n6m 170 23 are be VBP cord-347946-i6kx3n6m 170 24 ancient ancient JJ cord-347946-i6kx3n6m 170 25 and and CC cord-347946-i6kx3n6m 170 26 hence hence RB cord-347946-i6kx3n6m 170 27 potentially potentially RB cord-347946-i6kx3n6m 170 28 adaptive adaptive JJ cord-347946-i6kx3n6m 170 29 , , , cord-347946-i6kx3n6m 170 30 or or CC cord-347946-i6kx3n6m 170 31 are be VBP cord-347946-i6kx3n6m 170 32 of of IN cord-347946-i6kx3n6m 170 33 recent recent JJ cord-347946-i6kx3n6m 170 34 origin origin NN cord-347946-i6kx3n6m 170 35 and and CC cord-347946-i6kx3n6m 170 36 thus thus RB cord-347946-i6kx3n6m 170 37 likely likely RB cord-347946-i6kx3n6m 170 38 a a DT cord-347946-i6kx3n6m 170 39 result result NN cord-347946-i6kx3n6m 170 40 of of IN cord-347946-i6kx3n6m 170 41 non non JJ cord-347946-i6kx3n6m 170 42 - - JJ cord-347946-i6kx3n6m 170 43 adaptive adaptive JJ cord-347946-i6kx3n6m 170 44 evolutionary evolutionary JJ cord-347946-i6kx3n6m 170 45 mismatch mismatch NN cord-347946-i6kx3n6m 170 46 . . . cord-347946-i6kx3n6m 171 1 One one PRP cord-347946-i6kx3n6m 171 2 can can MD cord-347946-i6kx3n6m 171 3 only only RB cord-347946-i6kx3n6m 171 4 mourn mourn VB cord-347946-i6kx3n6m 171 5 the the DT cord-347946-i6kx3n6m 171 6 fact fact NN cord-347946-i6kx3n6m 171 7 that that IN cord-347946-i6kx3n6m 171 8 the the DT cord-347946-i6kx3n6m 171 9 theoretical theoretical JJ cord-347946-i6kx3n6m 171 10 perspectives perspective NNS cord-347946-i6kx3n6m 171 11 and and CC cord-347946-i6kx3n6m 171 12 technology technology NN cord-347946-i6kx3n6m 171 13 necessary necessary JJ cord-347946-i6kx3n6m 171 14 to to TO cord-347946-i6kx3n6m 171 15 resolve resolve VB cord-347946-i6kx3n6m 171 16 this this DT cord-347946-i6kx3n6m 171 17 issue issue NN cord-347946-i6kx3n6m 171 18 were be VBD cord-347946-i6kx3n6m 171 19 not not RB cord-347946-i6kx3n6m 171 20 available available JJ cord-347946-i6kx3n6m 171 21 in in IN cord-347946-i6kx3n6m 171 22 the the DT cord-347946-i6kx3n6m 171 23 middle middle JJ cord-347946-i6kx3n6m 171 24 years year NNS cord-347946-i6kx3n6m 171 25 of of IN cord-347946-i6kx3n6m 171 26 the the DT cord-347946-i6kx3n6m 171 27 20th 20th JJ cord-347946-i6kx3n6m 171 28 Century century NN cord-347946-i6kx3n6m 171 29 when when WRB cord-347946-i6kx3n6m 171 30 a a DT cord-347946-i6kx3n6m 171 31 range range NN cord-347946-i6kx3n6m 171 32 of of IN cord-347946-i6kx3n6m 171 33 hunter hunter NN cord-347946-i6kx3n6m 171 34 - - HYPH cord-347946-i6kx3n6m 171 35 gatherer gatherer NN cord-347946-i6kx3n6m 171 36 groups group NNS cord-347946-i6kx3n6m 171 37 on on IN cord-347946-i6kx3n6m 171 38 several several JJ cord-347946-i6kx3n6m 171 39 continents continent NNS cord-347946-i6kx3n6m 171 40 had have VBD cord-347946-i6kx3n6m 171 41 yet yet RB cord-347946-i6kx3n6m 171 42 to to TO cord-347946-i6kx3n6m 171 43 be be VB cord-347946-i6kx3n6m 171 44 driven drive VBN cord-347946-i6kx3n6m 171 45 to to IN cord-347946-i6kx3n6m 171 46 extinction extinction NN cord-347946-i6kx3n6m 171 47 by by IN cord-347946-i6kx3n6m 171 48 the the DT cord-347946-i6kx3n6m 171 49 inexorable inexorable JJ cord-347946-i6kx3n6m 171 50 onrush onrush NN cord-347946-i6kx3n6m 171 51 of of IN cord-347946-i6kx3n6m 171 52 the the DT cord-347946-i6kx3n6m 171 53 modern modern JJ cord-347946-i6kx3n6m 171 54 world world NN cord-347946-i6kx3n6m 171 55 . . . cord-347946-i6kx3n6m 172 1 PATHOS pathos NN cord-347946-i6kx3n6m 172 2 - - HYPH cord-347946-i6kx3n6m 172 3 D d JJ cord-347946-i6kx3n6m 172 4 theory theory NN cord-347946-i6kx3n6m 172 5 engenders engender VBZ cord-347946-i6kx3n6m 172 6 a a DT cord-347946-i6kx3n6m 172 7 sense sense NN cord-347946-i6kx3n6m 172 8 of of IN cord-347946-i6kx3n6m 172 9 urgency urgency NN cord-347946-i6kx3n6m 172 10 to to TO cord-347946-i6kx3n6m 172 11 examine examine VB cord-347946-i6kx3n6m 172 12 this this DT cord-347946-i6kx3n6m 172 13 issue issue NN cord-347946-i6kx3n6m 172 14 in in IN cord-347946-i6kx3n6m 172 15 the the DT cord-347946-i6kx3n6m 172 16 remnant remnant JJ cord-347946-i6kx3n6m 172 17 small small JJ cord-347946-i6kx3n6m 172 18 - - HYPH cord-347946-i6kx3n6m 172 19 scale scale NN cord-347946-i6kx3n6m 172 20 societies society NNS cord-347946-i6kx3n6m 172 21 that that WDT cord-347946-i6kx3n6m 172 22 remain remain VBP cord-347946-i6kx3n6m 172 23 . . . cord-347946-i6kx3n6m 173 1 Two two CD cord-347946-i6kx3n6m 173 2 types type NNS cord-347946-i6kx3n6m 173 3 of of IN cord-347946-i6kx3n6m 173 4 studies study NNS cord-347946-i6kx3n6m 173 5 would would MD cord-347946-i6kx3n6m 173 6 be be VB cord-347946-i6kx3n6m 173 7 especially especially RB cord-347946-i6kx3n6m 173 8 relevant relevant JJ cord-347946-i6kx3n6m 173 9 . . . cord-347946-i6kx3n6m 174 1 First first RB cord-347946-i6kx3n6m 174 2 , , , cord-347946-i6kx3n6m 174 3 it -PRON- PRP cord-347946-i6kx3n6m 174 4 would would MD cord-347946-i6kx3n6m 174 5 be be VB cord-347946-i6kx3n6m 174 6 of of IN cord-347946-i6kx3n6m 174 7 great great JJ cord-347946-i6kx3n6m 174 8 interest interest NN cord-347946-i6kx3n6m 174 9 to to TO cord-347946-i6kx3n6m 174 10 conduct conduct VB cord-347946-i6kx3n6m 174 11 the the DT cord-347946-i6kx3n6m 174 12 equivalent equivalent NN cord-347946-i6kx3n6m 174 13 of of IN cord-347946-i6kx3n6m 174 14 Trier Trier NNP cord-347946-i6kx3n6m 174 15 Social Social NNP cord-347946-i6kx3n6m 174 16 Stress Stress NNP cord-347946-i6kx3n6m 174 17 Tests Tests NNPS cord-347946-i6kx3n6m 174 18 in in IN cord-347946-i6kx3n6m 174 19 these these DT cord-347946-i6kx3n6m 174 20 societies society NNS cord-347946-i6kx3n6m 174 21 to to TO cord-347946-i6kx3n6m 174 22 examine examine VB cord-347946-i6kx3n6m 174 23 whether whether IN cord-347946-i6kx3n6m 174 24 objectively objectively RB cord-347946-i6kx3n6m 174 25 induced induce VBN cord-347946-i6kx3n6m 174 26 psychosocial psychosocial JJ cord-347946-i6kx3n6m 174 27 stress stress NN cord-347946-i6kx3n6m 174 28 activates activate VBZ cord-347946-i6kx3n6m 174 29 inflammatory inflammatory JJ cord-347946-i6kx3n6m 174 30 pathways pathway NNS cord-347946-i6kx3n6m 174 31 as as IN cord-347946-i6kx3n6m 174 32 it -PRON- PRP cord-347946-i6kx3n6m 174 33 does do VBZ cord-347946-i6kx3n6m 174 34 in in IN cord-347946-i6kx3n6m 174 35 the the DT cord-347946-i6kx3n6m 174 36 West West NNP cord-347946-i6kx3n6m 174 37 . . . cord-347946-i6kx3n6m 175 1 Second second RB cord-347946-i6kx3n6m 175 2 , , , cord-347946-i6kx3n6m 175 3 it -PRON- PRP cord-347946-i6kx3n6m 175 4 would would MD cord-347946-i6kx3n6m 175 5 be be VB cord-347946-i6kx3n6m 175 6 important important JJ cord-347946-i6kx3n6m 175 7 to to TO cord-347946-i6kx3n6m 175 8 examine examine VB cord-347946-i6kx3n6m 175 9 whether whether IN cord-347946-i6kx3n6m 175 10 the the DT cord-347946-i6kx3n6m 175 11 administration administration NN cord-347946-i6kx3n6m 175 12 of of IN cord-347946-i6kx3n6m 175 13 cytokine cytokine NN cord-347946-i6kx3n6m 175 14 activators activator NNS cord-347946-i6kx3n6m 175 15 ( ( -LRB- cord-347946-i6kx3n6m 175 16 ie ie NNS cord-347946-i6kx3n6m 175 17 , , , cord-347946-i6kx3n6m 175 18 endotoxin endotoxin NN cord-347946-i6kx3n6m 175 19 , , , cord-347946-i6kx3n6m 175 20 typhoid typhoid NN cord-347946-i6kx3n6m 175 21 vaccine vaccine NN cord-347946-i6kx3n6m 175 22 or or CC cord-347946-i6kx3n6m 175 23 longer long JJR cord-347946-i6kx3n6m 175 24 - - HYPH cord-347946-i6kx3n6m 175 25 term term NN cord-347946-i6kx3n6m 175 26 treatment treatment NN cord-347946-i6kx3n6m 175 27 with with IN cord-347946-i6kx3n6m 175 28 IFN IFN NNP cord-347946-i6kx3n6m 175 29 - - HYPH cord-347946-i6kx3n6m 175 30 α α NNP cord-347946-i6kx3n6m 175 31 ) ) -RRB- cord-347946-i6kx3n6m 175 32 produce produce VBP cord-347946-i6kx3n6m 175 33 depressive depressive JJ cord-347946-i6kx3n6m 175 34 symptoms symptom NNS cord-347946-i6kx3n6m 175 35 as as IN cord-347946-i6kx3n6m 175 36 they -PRON- PRP cord-347946-i6kx3n6m 175 37 do do VBP cord-347946-i6kx3n6m 175 38 in in IN cord-347946-i6kx3n6m 175 39 the the DT cord-347946-i6kx3n6m 175 40 industrialized industrialized JJ cord-347946-i6kx3n6m 175 41 world world NN cord-347946-i6kx3n6m 175 42 . . . cord-347946-i6kx3n6m 176 1 If if IN cord-347946-i6kx3n6m 176 2 individuals individual NNS cord-347946-i6kx3n6m 176 3 living live VBG cord-347946-i6kx3n6m 176 4 in in IN cord-347946-i6kx3n6m 176 5 environments environment NNS cord-347946-i6kx3n6m 176 6 more more RBR cord-347946-i6kx3n6m 176 7 closely closely RB cord-347946-i6kx3n6m 176 8 aligned align VBN cord-347946-i6kx3n6m 176 9 with with IN cord-347946-i6kx3n6m 176 10 prototypical prototypical JJ cord-347946-i6kx3n6m 176 11 conditions condition NNS cord-347946-i6kx3n6m 176 12 in in IN cord-347946-i6kx3n6m 176 13 the the DT cord-347946-i6kx3n6m 176 14 EEA EEA NNP cord-347946-i6kx3n6m 176 15 showed show VBD cord-347946-i6kx3n6m 176 16 inflammatory inflammatory JJ cord-347946-i6kx3n6m 176 17 responses response NNS cord-347946-i6kx3n6m 176 18 to to IN cord-347946-i6kx3n6m 176 19 psychosocial psychosocial JJ cord-347946-i6kx3n6m 176 20 stress stress NN cord-347946-i6kx3n6m 176 21 and and CC cord-347946-i6kx3n6m 176 22 if if IN cord-347946-i6kx3n6m 176 23 they -PRON- PRP cord-347946-i6kx3n6m 176 24 responded respond VBD cord-347946-i6kx3n6m 176 25 to to IN cord-347946-i6kx3n6m 176 26 immune immune JJ cord-347946-i6kx3n6m 176 27 stimulation stimulation NN cord-347946-i6kx3n6m 176 28 with with IN cord-347946-i6kx3n6m 176 29 depression depression NN cord-347946-i6kx3n6m 176 30 , , , cord-347946-i6kx3n6m 176 31 strong strong JJ cord-347946-i6kx3n6m 176 32 evidence evidence NN cord-347946-i6kx3n6m 176 33 in in IN cord-347946-i6kx3n6m 176 34 support support NN cord-347946-i6kx3n6m 176 35 of of IN cord-347946-i6kx3n6m 176 36 PATHOS pathos NN cord-347946-i6kx3n6m 176 37 - - HYPH cord-347946-i6kx3n6m 176 38 D D NNP cord-347946-i6kx3n6m 176 39 would would MD cord-347946-i6kx3n6m 176 40 have have VB cord-347946-i6kx3n6m 176 41 been be VBN cord-347946-i6kx3n6m 176 42 obtained obtain VBN cord-347946-i6kx3n6m 176 43 . . . cord-347946-i6kx3n6m 177 1 From from IN cord-347946-i6kx3n6m 177 2 a a DT cord-347946-i6kx3n6m 177 3 PATHOS pathos NN cord-347946-i6kx3n6m 177 4 - - HYPH cord-347946-i6kx3n6m 177 5 D d NN cord-347946-i6kx3n6m 177 6 perspective perspective NN cord-347946-i6kx3n6m 177 7 there there EX cord-347946-i6kx3n6m 177 8 is be VBZ cord-347946-i6kx3n6m 177 9 no no DT cord-347946-i6kx3n6m 177 10 a a FW cord-347946-i6kx3n6m 177 11 priori priori JJ cord-347946-i6kx3n6m 177 12 reason reason NN cord-347946-i6kx3n6m 177 13 that that IN cord-347946-i6kx3n6m 177 14 MDD MDD NNP cord-347946-i6kx3n6m 177 15 should should MD cord-347946-i6kx3n6m 177 16 be be VB cord-347946-i6kx3n6m 177 17 associated associate VBN cord-347946-i6kx3n6m 177 18 with with IN cord-347946-i6kx3n6m 177 19 increased increase VBN cord-347946-i6kx3n6m 177 20 inflammation inflammation NN cord-347946-i6kx3n6m 177 21 , , , cord-347946-i6kx3n6m 177 22 only only RB cord-347946-i6kx3n6m 177 23 that that IN cord-347946-i6kx3n6m 177 24 MDD MDD NNP cord-347946-i6kx3n6m 177 25 be be VB cord-347946-i6kx3n6m 177 26 associated associate VBN cord-347946-i6kx3n6m 177 27 with with IN cord-347946-i6kx3n6m 177 28 genes gene NNS cord-347946-i6kx3n6m 177 29 , , , cord-347946-i6kx3n6m 177 30 physiology physiology NN cord-347946-i6kx3n6m 177 31 and and CC cord-347946-i6kx3n6m 177 32 behavior behavior NN cord-347946-i6kx3n6m 177 33 that that WDT cord-347946-i6kx3n6m 177 34 - - HYPH cord-347946-i6kx3n6m 177 35 on on RP cord-347946-i6kx3n6m 177 36 average average JJ cord-347946-i6kx3n6m 177 37 - - HYPH cord-347946-i6kx3n6m 177 38 decreased decrease VBN cord-347946-i6kx3n6m 177 39 infectious infectious JJ cord-347946-i6kx3n6m 177 40 mortality mortality NN cord-347946-i6kx3n6m 177 41 across across IN cord-347946-i6kx3n6m 177 42 human human JJ cord-347946-i6kx3n6m 177 43 evolution evolution NN cord-347946-i6kx3n6m 177 44 . . . cord-347946-i6kx3n6m 178 1 The the DT cord-347946-i6kx3n6m 178 2 fact fact NN cord-347946-i6kx3n6m 178 3 that that IN cord-347946-i6kx3n6m 178 4 a a DT cord-347946-i6kx3n6m 178 5 subset subset NN cord-347946-i6kx3n6m 178 6 of of IN cord-347946-i6kx3n6m 178 7 patients patient NNS cord-347946-i6kx3n6m 178 8 with with IN cord-347946-i6kx3n6m 178 9 MDD MDD NNP cord-347946-i6kx3n6m 178 10 demonstrate demonstrate VBP cord-347946-i6kx3n6m 178 11 increased increase VBN cord-347946-i6kx3n6m 178 12 inflammation inflammation NN cord-347946-i6kx3n6m 178 13 implies imply VBZ cord-347946-i6kx3n6m 178 14 the the DT cord-347946-i6kx3n6m 178 15 hypothesis hypothesis NN cord-347946-i6kx3n6m 178 16 that that IN cord-347946-i6kx3n6m 178 17 if if IN cord-347946-i6kx3n6m 178 18 depression depression NN cord-347946-i6kx3n6m 178 19 is be VBZ cord-347946-i6kx3n6m 178 20 associated associate VBN cord-347946-i6kx3n6m 178 21 with with IN cord-347946-i6kx3n6m 178 22 increased increase VBN cord-347946-i6kx3n6m 178 23 inflammation inflammation NN cord-347946-i6kx3n6m 178 24 , , , cord-347946-i6kx3n6m 178 25 and and CC cord-347946-i6kx3n6m 178 26 if if IN cord-347946-i6kx3n6m 178 27 depression depression NN cord-347946-i6kx3n6m 178 28 evolved evolve VBD cord-347946-i6kx3n6m 178 29 as as IN cord-347946-i6kx3n6m 178 30 an an DT cord-347946-i6kx3n6m 178 31 adaptive adaptive JJ cord-347946-i6kx3n6m 178 32 pathogen pathogen NN cord-347946-i6kx3n6m 178 33 - - HYPH cord-347946-i6kx3n6m 178 34 host host NN cord-347946-i6kx3n6m 178 35 defense defense NN cord-347946-i6kx3n6m 178 36 strategy strategy NN cord-347946-i6kx3n6m 178 37 , , , cord-347946-i6kx3n6m 178 38 then then RB cord-347946-i6kx3n6m 178 39 increased increase VBD cord-347946-i6kx3n6m 178 40 inflammatory inflammatory JJ cord-347946-i6kx3n6m 178 41 activity activity NN cord-347946-i6kx3n6m 178 42 should should MD cord-347946-i6kx3n6m 178 43 have have VB cord-347946-i6kx3n6m 178 44 produced produce VBN cord-347946-i6kx3n6m 178 45 an an DT cord-347946-i6kx3n6m 178 46 overall overall JJ cord-347946-i6kx3n6m 178 47 survival survival NN cord-347946-i6kx3n6m 178 48 benefit benefit NN cord-347946-i6kx3n6m 178 49 in in IN cord-347946-i6kx3n6m 178 50 high high JJ cord-347946-i6kx3n6m 178 51 - - HYPH cord-347946-i6kx3n6m 178 52 pathogen pathogen NN cord-347946-i6kx3n6m 178 53 ancient ancient JJ cord-347946-i6kx3n6m 178 54 environments environment NNS cord-347946-i6kx3n6m 178 55 , , , cord-347946-i6kx3n6m 178 56 if if IN cord-347946-i6kx3n6m 178 57 indeed indeed RB cord-347946-i6kx3n6m 178 58 the the DT cord-347946-i6kx3n6m 178 59 association association NN cord-347946-i6kx3n6m 178 60 between between IN cord-347946-i6kx3n6m 178 61 depression depression NN cord-347946-i6kx3n6m 178 62 and and CC cord-347946-i6kx3n6m 178 63 inflammation inflammation NN cord-347946-i6kx3n6m 178 64 was be VBD cord-347946-i6kx3n6m 178 65 adaptive adaptive JJ cord-347946-i6kx3n6m 178 66 in in IN cord-347946-i6kx3n6m 178 67 the the DT cord-347946-i6kx3n6m 178 68 EEA EEA NNP cord-347946-i6kx3n6m 178 69 . . . cord-347946-i6kx3n6m 179 1 For for IN cord-347946-i6kx3n6m 179 2 this this DT cord-347946-i6kx3n6m 179 3 idea idea NN cord-347946-i6kx3n6m 179 4 to to TO cord-347946-i6kx3n6m 179 5 be be VB cord-347946-i6kx3n6m 179 6 credible credible JJ cord-347946-i6kx3n6m 179 7 two two CD cord-347946-i6kx3n6m 179 8 things thing NNS cord-347946-i6kx3n6m 179 9 are be VBP cord-347946-i6kx3n6m 179 10 required require VBN cord-347946-i6kx3n6m 179 11 : : : cord-347946-i6kx3n6m 179 12 first first JJ cord-347946-i6kx3n6m 179 13 depression depression NN cord-347946-i6kx3n6m 179 14 should should MD cord-347946-i6kx3n6m 179 15 enhance enhance VB cord-347946-i6kx3n6m 179 16 host host NN cord-347946-i6kx3n6m 179 17 defense defense NN cord-347946-i6kx3n6m 179 18 , , , cord-347946-i6kx3n6m 179 19 and and CC cord-347946-i6kx3n6m 179 20 second second JJ cord-347946-i6kx3n6m 179 21 inflammation inflammation NN cord-347946-i6kx3n6m 179 22 should should MD cord-347946-i6kx3n6m 179 23 enhance enhance VB cord-347946-i6kx3n6m 179 24 host host NN cord-347946-i6kx3n6m 179 25 defense defense NN cord-347946-i6kx3n6m 179 26 . . . cord-347946-i6kx3n6m 180 1 On on IN cord-347946-i6kx3n6m 180 2 the the DT cord-347946-i6kx3n6m 180 3 face face NN cord-347946-i6kx3n6m 180 4 of of IN cord-347946-i6kx3n6m 180 5 it -PRON- PRP cord-347946-i6kx3n6m 180 6 , , , cord-347946-i6kx3n6m 180 7 neither neither CC cord-347946-i6kx3n6m 180 8 appears appear VBZ cord-347946-i6kx3n6m 180 9 to to TO cord-347946-i6kx3n6m 180 10 be be VB cord-347946-i6kx3n6m 180 11 true true JJ cord-347946-i6kx3n6m 180 12 , , , cord-347946-i6kx3n6m 180 13 given give VBN cord-347946-i6kx3n6m 180 14 significant significant JJ cord-347946-i6kx3n6m 180 15 evidence evidence NN cord-347946-i6kx3n6m 180 16 that that IN cord-347946-i6kx3n6m 180 17 both both DT cord-347946-i6kx3n6m 180 18 depression depression NN cord-347946-i6kx3n6m 180 19 and and CC cord-347946-i6kx3n6m 180 20 inflammation inflammation NN cord-347946-i6kx3n6m 180 21 appear appear VBP cord-347946-i6kx3n6m 180 22 to to TO cord-347946-i6kx3n6m 180 23 increase increase VB cord-347946-i6kx3n6m 180 24 - - : cord-347946-i6kx3n6m 180 25 rather rather RB cord-347946-i6kx3n6m 180 26 than than IN cord-347946-i6kx3n6m 180 27 decrease decrease NN cord-347946-i6kx3n6m 180 28 - - HYPH cord-347946-i6kx3n6m 180 29 vulnerability vulnerability NN cord-347946-i6kx3n6m 180 30 to to IN cord-347946-i6kx3n6m 180 31 infection infection NN cord-347946-i6kx3n6m 181 1 ( ( -LRB- cord-347946-i6kx3n6m 181 2 Zorrilla Zorrilla NNP cord-347946-i6kx3n6m 181 3 et et FW cord-347946-i6kx3n6m 181 4 al al NNP cord-347946-i6kx3n6m 181 5 , , , cord-347946-i6kx3n6m 181 6 1996 1996 CD cord-347946-i6kx3n6m 181 7 ; ; : cord-347946-i6kx3n6m 181 8 Evans Evans NNP cord-347946-i6kx3n6m 181 9 et et NNP cord-347946-i6kx3n6m 181 10 al al NNP cord-347946-i6kx3n6m 181 11 , , , cord-347946-i6kx3n6m 181 12 2002 2002 CD cord-347946-i6kx3n6m 181 13 ; ; : cord-347946-i6kx3n6m 181 14 Cruess Cruess NNP cord-347946-i6kx3n6m 181 15 et et NNP cord-347946-i6kx3n6m 181 16 al al NNP cord-347946-i6kx3n6m 181 17 , , , cord-347946-i6kx3n6m 181 18 2003 2003 CD cord-347946-i6kx3n6m 181 19 ; ; : cord-347946-i6kx3n6m 181 20 Raison Raison NNP cord-347946-i6kx3n6m 181 21 et et NNP cord-347946-i6kx3n6m 181 22 al al NNP cord-347946-i6kx3n6m 181 23 , , , cord-347946-i6kx3n6m 181 24 2005 2005 CD cord-347946-i6kx3n6m 181 25 ; ; : cord-347946-i6kx3n6m 181 26 Doering Doering NNP cord-347946-i6kx3n6m 181 27 et et FW cord-347946-i6kx3n6m 181 28 al al NNP cord-347946-i6kx3n6m 181 29 , , , cord-347946-i6kx3n6m 181 30 2008 2008 CD cord-347946-i6kx3n6m 181 31 ; ; : cord-347946-i6kx3n6m 182 1 Faulkner Faulkner NNP cord-347946-i6kx3n6m 182 2 and and CC cord-347946-i6kx3n6m 182 3 Smith Smith NNP cord-347946-i6kx3n6m 182 4 , , , cord-347946-i6kx3n6m 182 5 2008 2008 CD cord-347946-i6kx3n6m 182 6 ; ; : cord-347946-i6kx3n6m 182 7 Leserman Leserman NNP cord-347946-i6kx3n6m 182 8 , , , cord-347946-i6kx3n6m 182 9 2008 2008 CD cord-347946-i6kx3n6m 182 10 ; ; : cord-347946-i6kx3n6m 182 11 Leutscher Leutscher NNP cord-347946-i6kx3n6m 182 12 et et NNP cord-347946-i6kx3n6m 182 13 al al NNP cord-347946-i6kx3n6m 182 14 , , , cord-347946-i6kx3n6m 182 15 2010 2010 CD cord-347946-i6kx3n6m 182 16 ; ; : cord-347946-i6kx3n6m 182 17 Andersson Andersson NNP cord-347946-i6kx3n6m 182 18 et et NNP cord-347946-i6kx3n6m 182 19 al al NNP cord-347946-i6kx3n6m 182 20 , , , cord-347946-i6kx3n6m 182 21 2016 2016 CD cord-347946-i6kx3n6m 182 22 ; ; : cord-347946-i6kx3n6m 182 23 Doran Doran NNP cord-347946-i6kx3n6m 182 24 et et NNP cord-347946-i6kx3n6m 182 25 al al NNP cord-347946-i6kx3n6m 182 26 , , , cord-347946-i6kx3n6m 182 27 2002 2002 CD cord-347946-i6kx3n6m 182 28 ) ) -RRB- cord-347946-i6kx3n6m 182 29 . . . cord-347946-i6kx3n6m 183 1 Here here RB cord-347946-i6kx3n6m 183 2 we -PRON- PRP cord-347946-i6kx3n6m 183 3 consider consider VBP cord-347946-i6kx3n6m 183 4 the the DT cord-347946-i6kx3n6m 183 5 question question NN cord-347946-i6kx3n6m 183 6 of of IN cord-347946-i6kx3n6m 183 7 whether whether IN cord-347946-i6kx3n6m 183 8 inflammatory inflammatory JJ cord-347946-i6kx3n6m 183 9 activity activity NN cord-347946-i6kx3n6m 183 10 provided provide VBD cord-347946-i6kx3n6m 183 11 protection protection NN cord-347946-i6kx3n6m 183 12 against against IN cord-347946-i6kx3n6m 183 13 infectious infectious JJ cord-347946-i6kx3n6m 183 14 mortality mortality NN cord-347946-i6kx3n6m 183 15 . . . cord-347946-i6kx3n6m 184 1 For for IN cord-347946-i6kx3n6m 184 2 at at RB cord-347946-i6kx3n6m 184 3 least least RBS cord-347946-i6kx3n6m 184 4 2000 2000 CD cord-347946-i6kx3n6m 184 5 years year NNS cord-347946-i6kx3n6m 184 6 it -PRON- PRP cord-347946-i6kx3n6m 184 7 has have VBZ cord-347946-i6kx3n6m 184 8 been be VBN cord-347946-i6kx3n6m 184 9 recognized recognize VBN cord-347946-i6kx3n6m 184 10 that that IN cord-347946-i6kx3n6m 184 11 inflammation inflammation NN cord-347946-i6kx3n6m 184 12 is be VBZ cord-347946-i6kx3n6m 184 13 essential essential JJ cord-347946-i6kx3n6m 184 14 for for IN cord-347946-i6kx3n6m 184 15 human human JJ cord-347946-i6kx3n6m 184 16 health health NN cord-347946-i6kx3n6m 184 17 and and CC cord-347946-i6kx3n6m 184 18 a a DT cord-347946-i6kx3n6m 184 19 necessary necessary JJ cord-347946-i6kx3n6m 184 20 ingredient ingredient NN cord-347946-i6kx3n6m 184 21 of of IN cord-347946-i6kx3n6m 184 22 our -PRON- PRP$ cord-347946-i6kx3n6m 184 23 ability ability NN cord-347946-i6kx3n6m 184 24 to to TO cord-347946-i6kx3n6m 184 25 adequately adequately RB cord-347946-i6kx3n6m 184 26 fight fight VB cord-347946-i6kx3n6m 184 27 infections infection NNS cord-347946-i6kx3n6m 184 28 . . . cord-347946-i6kx3n6m 185 1 We -PRON- PRP cord-347946-i6kx3n6m 185 2 now now RB cord-347946-i6kx3n6m 185 3 know know VBP cord-347946-i6kx3n6m 185 4 that that IN cord-347946-i6kx3n6m 185 5 the the DT cord-347946-i6kx3n6m 185 6 larger large JJR cord-347946-i6kx3n6m 185 7 innate innate JJ cord-347946-i6kx3n6m 185 8 immune immune JJ cord-347946-i6kx3n6m 185 9 response response NN cord-347946-i6kx3n6m 185 10 - - : cord-347946-i6kx3n6m 185 11 of of IN cord-347946-i6kx3n6m 185 12 which which WDT cord-347946-i6kx3n6m 185 13 inflammation inflammation NN cord-347946-i6kx3n6m 185 14 is be VBZ cord-347946-i6kx3n6m 185 15 a a DT cord-347946-i6kx3n6m 185 16 core core NN cord-347946-i6kx3n6m 185 17 component component NN cord-347946-i6kx3n6m 185 18 - - : cord-347946-i6kx3n6m 185 19 provides provide VBZ cord-347946-i6kx3n6m 185 20 both both DT cord-347946-i6kx3n6m 185 21 direct direct JJ cord-347946-i6kx3n6m 185 22 and and CC cord-347946-i6kx3n6m 185 23 rapid rapid JJ cord-347946-i6kx3n6m 185 24 protection protection NN cord-347946-i6kx3n6m 185 25 against against IN cord-347946-i6kx3n6m 185 26 all all DT cord-347946-i6kx3n6m 185 27 classes class NNS cord-347946-i6kx3n6m 185 28 of of IN cord-347946-i6kx3n6m 185 29 pathogens pathogen NNS cord-347946-i6kx3n6m 185 30 and and CC cord-347946-i6kx3n6m 185 31 has have VBZ cord-347946-i6kx3n6m 185 32 a a DT cord-347946-i6kx3n6m 185 33 crucial crucial JJ cord-347946-i6kx3n6m 185 34 role role NN cord-347946-i6kx3n6m 185 35 in in IN cord-347946-i6kx3n6m 185 36 activating activate VBG cord-347946-i6kx3n6m 185 37 slower slow JJR cord-347946-i6kx3n6m 185 38 , , , cord-347946-i6kx3n6m 185 39 but but CC cord-347946-i6kx3n6m 185 40 more more RBR cord-347946-i6kx3n6m 185 41 definitive definitive JJ cord-347946-i6kx3n6m 185 42 acquired acquire VBN cord-347946-i6kx3n6m 185 43 immune immune JJ cord-347946-i6kx3n6m 185 44 responses response NNS cord-347946-i6kx3n6m 185 45 . . . cord-347946-i6kx3n6m 186 1 However however RB cord-347946-i6kx3n6m 186 2 , , , cord-347946-i6kx3n6m 186 3 studies study NNS cord-347946-i6kx3n6m 186 4 in in IN cord-347946-i6kx3n6m 186 5 recent recent JJ cord-347946-i6kx3n6m 186 6 years year NNS cord-347946-i6kx3n6m 186 7 have have VBP cord-347946-i6kx3n6m 186 8 found find VBN cord-347946-i6kx3n6m 186 9 that that IN cord-347946-i6kx3n6m 186 10 the the DT cord-347946-i6kx3n6m 186 11 relationship relationship NN cord-347946-i6kx3n6m 186 12 between between IN cord-347946-i6kx3n6m 186 13 the the DT cord-347946-i6kx3n6m 186 14 innate innate NN cord-347946-i6kx3n6m 186 15 and and CC cord-347946-i6kx3n6m 186 16 acquired acquire VBD cord-347946-i6kx3n6m 186 17 immune immune JJ cord-347946-i6kx3n6m 186 18 systems system NNS cord-347946-i6kx3n6m 186 19 follows follow VBZ cord-347946-i6kx3n6m 186 20 the the DT cord-347946-i6kx3n6m 186 21 laws law NNS cord-347946-i6kx3n6m 186 22 of of IN cord-347946-i6kx3n6m 186 23 cooperation cooperation NN cord-347946-i6kx3n6m 186 24 and and CC cord-347946-i6kx3n6m 186 25 competition competition NN cord-347946-i6kx3n6m 186 26 that that WDT cord-347946-i6kx3n6m 186 27 define define VBP cord-347946-i6kx3n6m 186 28 all all DT cord-347946-i6kx3n6m 186 29 evolved evolve VBN cord-347946-i6kx3n6m 186 30 relationships relationship NNS cord-347946-i6kx3n6m 186 31 . . . cord-347946-i6kx3n6m 187 1 Especially especially RB cord-347946-i6kx3n6m 187 2 under under IN cord-347946-i6kx3n6m 187 3 conditions condition NNS cord-347946-i6kx3n6m 187 4 of of IN cord-347946-i6kx3n6m 187 5 limited limited JJ cord-347946-i6kx3n6m 187 6 energy energy NN cord-347946-i6kx3n6m 187 7 availability availability NN cord-347946-i6kx3n6m 187 8 or or CC cord-347946-i6kx3n6m 187 9 simultaneous simultaneous JJ cord-347946-i6kx3n6m 187 10 infectious infectious JJ cord-347946-i6kx3n6m 187 11 risk risk NN cord-347946-i6kx3n6m 187 12 from from IN cord-347946-i6kx3n6m 187 13 multiple multiple JJ cord-347946-i6kx3n6m 187 14 pathogens pathogen NNS cord-347946-i6kx3n6m 187 15 , , , cord-347946-i6kx3n6m 187 16 immune immune JJ cord-347946-i6kx3n6m 187 17 function function NN cord-347946-i6kx3n6m 187 18 can can MD cord-347946-i6kx3n6m 187 19 become become VB cord-347946-i6kx3n6m 187 20 characterized characterize VBN cord-347946-i6kx3n6m 187 21 by by IN cord-347946-i6kx3n6m 187 22 trade trade NN cord-347946-i6kx3n6m 187 23 - - HYPH cord-347946-i6kx3n6m 187 24 offs off NNS cord-347946-i6kx3n6m 187 25 between between IN cord-347946-i6kx3n6m 187 26 these these DT cord-347946-i6kx3n6m 187 27 two two CD cord-347946-i6kx3n6m 187 28 branches branch NNS cord-347946-i6kx3n6m 187 29 of of IN cord-347946-i6kx3n6m 187 30 immunity immunity NN cord-347946-i6kx3n6m 187 31 , , , cord-347946-i6kx3n6m 187 32 such such JJ cord-347946-i6kx3n6m 187 33 that that IN cord-347946-i6kx3n6m 187 34 resources resource NNS cord-347946-i6kx3n6m 187 35 invested invest VBN cord-347946-i6kx3n6m 187 36 in in IN cord-347946-i6kx3n6m 187 37 one one CD cord-347946-i6kx3n6m 187 38 , , , cord-347946-i6kx3n6m 187 39 mean mean VB cord-347946-i6kx3n6m 187 40 reduced reduced JJ cord-347946-i6kx3n6m 187 41 functionality functionality NN cord-347946-i6kx3n6m 187 42 of of IN cord-347946-i6kx3n6m 187 43 the the DT cord-347946-i6kx3n6m 187 44 other other JJ cord-347946-i6kx3n6m 187 45 ( ( -LRB- cord-347946-i6kx3n6m 187 46 McDade McDade NNP cord-347946-i6kx3n6m 187 47 et et NNP cord-347946-i6kx3n6m 187 48 al al NNP cord-347946-i6kx3n6m 187 49 , , , cord-347946-i6kx3n6m 187 50 2016 2016 CD cord-347946-i6kx3n6m 187 51 ) ) -RRB- cord-347946-i6kx3n6m 187 52 . . . cord-347946-i6kx3n6m 188 1 Consistent consistent JJ cord-347946-i6kx3n6m 188 2 with with IN cord-347946-i6kx3n6m 188 3 this this DT cord-347946-i6kx3n6m 188 4 notion notion NN cord-347946-i6kx3n6m 188 5 , , , cord-347946-i6kx3n6m 188 6 chronic chronic JJ cord-347946-i6kx3n6m 188 7 inflammation inflammation NN cord-347946-i6kx3n6m 188 8 can can MD cord-347946-i6kx3n6m 188 9 actually actually RB cord-347946-i6kx3n6m 188 10 suppress suppress VB cord-347946-i6kx3n6m 188 11 T T NNP cord-347946-i6kx3n6m 188 12 - - HYPH cord-347946-i6kx3n6m 188 13 and and CC cord-347946-i6kx3n6m 188 14 B b NN cord-347946-i6kx3n6m 188 15 - - HYPH cord-347946-i6kx3n6m 188 16 cell cell NN cord-347946-i6kx3n6m 188 17 function function NN cord-347946-i6kx3n6m 188 18 through through IN cord-347946-i6kx3n6m 188 19 various various JJ cord-347946-i6kx3n6m 188 20 mechanisms mechanism NNS cord-347946-i6kx3n6m 188 21 ( ( -LRB- cord-347946-i6kx3n6m 188 22 Cope cope VB cord-347946-i6kx3n6m 188 23 et et FW cord-347946-i6kx3n6m 188 24 al al NNP cord-347946-i6kx3n6m 188 25 , , , cord-347946-i6kx3n6m 188 26 1997 1997 CD cord-347946-i6kx3n6m 188 27 ; ; : cord-347946-i6kx3n6m 188 28 Moraska Moraska NNP cord-347946-i6kx3n6m 188 29 et et NNP cord-347946-i6kx3n6m 188 30 al al NNP cord-347946-i6kx3n6m 188 31 , , , cord-347946-i6kx3n6m 188 32 2002 2002 CD cord-347946-i6kx3n6m 188 33 ; ; : cord-347946-i6kx3n6m 188 34 Cope cope VB cord-347946-i6kx3n6m 188 35 , , , cord-347946-i6kx3n6m 188 36 2003 2003 CD cord-347946-i6kx3n6m 188 37 ; ; : cord-347946-i6kx3n6m 188 38 Clark Clark NNP cord-347946-i6kx3n6m 188 39 et et NNP cord-347946-i6kx3n6m 188 40 al al NNP cord-347946-i6kx3n6m 188 41 , , , cord-347946-i6kx3n6m 188 42 2005 2005 CD cord-347946-i6kx3n6m 188 43 ; ; : cord-347946-i6kx3n6m 188 44 Muller Muller NNP cord-347946-i6kx3n6m 188 45 et et NNP cord-347946-i6kx3n6m 188 46 al al NNP cord-347946-i6kx3n6m 188 47 , , , cord-347946-i6kx3n6m 188 48 2008 2008 CD cord-347946-i6kx3n6m 188 49 ; ; : cord-347946-i6kx3n6m 188 50 Vaknin Vaknin NNP cord-347946-i6kx3n6m 188 51 et et NNP cord-347946-i6kx3n6m 188 52 al al NNP cord-347946-i6kx3n6m 188 53 , , , cord-347946-i6kx3n6m 188 54 2008 2008 CD cord-347946-i6kx3n6m 188 55 ; ; : cord-347946-i6kx3n6m 188 56 Eleftheriadis Eleftheriadis NNP cord-347946-i6kx3n6m 188 57 et et NNP cord-347946-i6kx3n6m 188 58 al al NNP cord-347946-i6kx3n6m 188 59 , , , cord-347946-i6kx3n6m 188 60 2009 2009 CD cord-347946-i6kx3n6m 188 61 ; ; : cord-347946-i6kx3n6m 188 62 Blume Blume NNP cord-347946-i6kx3n6m 188 63 et et NNP cord-347946-i6kx3n6m 188 64 al al NNP cord-347946-i6kx3n6m 188 65 , , , cord-347946-i6kx3n6m 188 66 2011 2011 CD cord-347946-i6kx3n6m 188 67 ) ) -RRB- cord-347946-i6kx3n6m 188 68 , , , cord-347946-i6kx3n6m 188 69 and and CC cord-347946-i6kx3n6m 188 70 rates rate NNS cord-347946-i6kx3n6m 188 71 of of IN cord-347946-i6kx3n6m 188 72 infection infection NN cord-347946-i6kx3n6m 188 73 are be VBP cord-347946-i6kx3n6m 188 74 often often RB cord-347946-i6kx3n6m 188 75 increased increase VBN cord-347946-i6kx3n6m 188 76 -not -not HYPH cord-347946-i6kx3n6m 188 77 decreased decrease VBN cord-347946-i6kx3n6m 188 78 - - HYPH cord-347946-i6kx3n6m 188 79 in in RP cord-347946-i6kx3n6m 188 80 autoimmune autoimmune JJ cord-347946-i6kx3n6m 188 81 conditions condition NNS cord-347946-i6kx3n6m 188 82 characterized characterize VBN cord-347946-i6kx3n6m 188 83 by by IN cord-347946-i6kx3n6m 188 84 chronic chronic JJ cord-347946-i6kx3n6m 188 85 inflammation inflammation NN cord-347946-i6kx3n6m 188 86 ( ( -LRB- cord-347946-i6kx3n6m 188 87 Doran Doran NNP cord-347946-i6kx3n6m 188 88 et et NNP cord-347946-i6kx3n6m 188 89 al al NNP cord-347946-i6kx3n6m 188 90 , , , cord-347946-i6kx3n6m 188 91 2002 2002 CD cord-347946-i6kx3n6m 188 92 ) ) -RRB- cord-347946-i6kx3n6m 188 93 . . . cord-347946-i6kx3n6m 189 1 However however RB cord-347946-i6kx3n6m 189 2 , , , cord-347946-i6kx3n6m 189 3 PATHOS pathos NN cord-347946-i6kx3n6m 189 4 - - HYPH cord-347946-i6kx3n6m 189 5 D d JJ cord-347946-i6kx3n6m 189 6 theory theory NN cord-347946-i6kx3n6m 189 7 requires require VBZ cord-347946-i6kx3n6m 189 8 only only RB cord-347946-i6kx3n6m 189 9 that that IN cord-347946-i6kx3n6m 189 10 across across IN cord-347946-i6kx3n6m 189 11 evolutionary evolutionary JJ cord-347946-i6kx3n6m 189 12 time time NN cord-347946-i6kx3n6m 189 13 the the DT cord-347946-i6kx3n6m 189 14 patterns pattern NNS cord-347946-i6kx3n6m 189 15 of of IN cord-347946-i6kx3n6m 189 16 enhanced enhance VBN cord-347946-i6kx3n6m 189 17 inflammatory inflammatory JJ cord-347946-i6kx3n6m 189 18 activity activity NN cord-347946-i6kx3n6m 189 19 characteristic characteristic NN cord-347946-i6kx3n6m 189 20 of of IN cord-347946-i6kx3n6m 189 21 depression depression NN cord-347946-i6kx3n6m 189 22 provided provide VBN cord-347946-i6kx3n6m 189 23 overall overall JJ cord-347946-i6kx3n6m 189 24 survival survival NN cord-347946-i6kx3n6m 189 25 benefits benefit NNS cord-347946-i6kx3n6m 189 26 that that WDT cord-347946-i6kx3n6m 189 27 outweighed outweigh VBD cord-347946-i6kx3n6m 189 28 any any DT cord-347946-i6kx3n6m 189 29 costs cost NNS cord-347946-i6kx3n6m 189 30 imposed impose VBN cord-347946-i6kx3n6m 189 31 by by IN cord-347946-i6kx3n6m 189 32 associated associated JJ cord-347946-i6kx3n6m 189 33 reductions reduction NNS cord-347946-i6kx3n6m 189 34 in in IN cord-347946-i6kx3n6m 189 35 other other JJ cord-347946-i6kx3n6m 189 36 aspects aspect NNS cord-347946-i6kx3n6m 189 37 of of IN cord-347946-i6kx3n6m 189 38 immune immune JJ cord-347946-i6kx3n6m 189 39 functioning functioning NN cord-347946-i6kx3n6m 189 40 . . . cord-347946-i6kx3n6m 190 1 Some some DT cord-347946-i6kx3n6m 190 2 evidence evidence NN cord-347946-i6kx3n6m 190 3 for for IN cord-347946-i6kx3n6m 190 4 this this DT cord-347946-i6kx3n6m 190 5 possibility possibility NN cord-347946-i6kx3n6m 190 6 comes come VBZ cord-347946-i6kx3n6m 190 7 from from IN cord-347946-i6kx3n6m 190 8 studies study NNS cord-347946-i6kx3n6m 190 9 conducted conduct VBN cord-347946-i6kx3n6m 190 10 by by IN cord-347946-i6kx3n6m 190 11 Westendorp Westendorp NNP cord-347946-i6kx3n6m 190 12 and and CC cord-347946-i6kx3n6m 190 13 colleagues colleague NNS cord-347946-i6kx3n6m 190 14 in in IN cord-347946-i6kx3n6m 190 15 Ghana Ghana NNP cord-347946-i6kx3n6m 190 16 and and CC cord-347946-i6kx3n6m 190 17 the the DT cord-347946-i6kx3n6m 190 18 Netherlands Netherlands NNP cord-347946-i6kx3n6m 190 19 . . . cord-347946-i6kx3n6m 191 1 These these DT cord-347946-i6kx3n6m 191 2 researchers researcher NNS cord-347946-i6kx3n6m 191 3 observed observe VBD cord-347946-i6kx3n6m 191 4 that that IN cord-347946-i6kx3n6m 191 5 cytokinestimulated cytokinestimulated JJ cord-347946-i6kx3n6m 191 6 production production NN cord-347946-i6kx3n6m 191 7 of of IN cord-347946-i6kx3n6m 191 8 TNF TNF NNP cord-347946-i6kx3n6m 191 9 - - HYPH cord-347946-i6kx3n6m 191 10 α α NNP cord-347946-i6kx3n6m 191 11 declines decline NNS cord-347946-i6kx3n6m 191 12 with with IN cord-347946-i6kx3n6m 191 13 age age NN cord-347946-i6kx3n6m 191 14 in in IN cord-347946-i6kx3n6m 191 15 the the DT cord-347946-i6kx3n6m 191 16 Netherlands Netherlands NNP cord-347946-i6kx3n6m 191 17 , , , cord-347946-i6kx3n6m 191 18 a a DT cord-347946-i6kx3n6m 191 19 country country NN cord-347946-i6kx3n6m 191 20 with with IN cord-347946-i6kx3n6m 191 21 a a DT cord-347946-i6kx3n6m 191 22 low low JJ cord-347946-i6kx3n6m 191 23 infectious infectious JJ cord-347946-i6kx3n6m 191 24 burden burden NN cord-347946-i6kx3n6m 191 25 , , , cord-347946-i6kx3n6m 191 26 but but CC cord-347946-i6kx3n6m 191 27 does do VBZ cord-347946-i6kx3n6m 191 28 not not RB cord-347946-i6kx3n6m 191 29 decline decline VB cord-347946-i6kx3n6m 191 30 with with IN cord-347946-i6kx3n6m 191 31 age age NN cord-347946-i6kx3n6m 191 32 in in IN cord-347946-i6kx3n6m 191 33 Ghana Ghana NNP cord-347946-i6kx3n6m 191 34 , , , cord-347946-i6kx3n6m 191 35 a a DT cord-347946-i6kx3n6m 191 36 country country NN cord-347946-i6kx3n6m 191 37 with with IN cord-347946-i6kx3n6m 191 38 high high JJ cord-347946-i6kx3n6m 191 39 rates rate NNS cord-347946-i6kx3n6m 191 40 of of IN cord-347946-i6kx3n6m 191 41 infection infection NN cord-347946-i6kx3n6m 191 42 ( ( -LRB- cord-347946-i6kx3n6m 191 43 ie ie FW cord-347946-i6kx3n6m 191 44 , , , cord-347946-i6kx3n6m 191 45 85 85 CD cord-347946-i6kx3n6m 191 46 % % NN cord-347946-i6kx3n6m 191 47 of of IN cord-347946-i6kx3n6m 191 48 Ghanan Ghanan NNP cord-347946-i6kx3n6m 191 49 study study NN cord-347946-i6kx3n6m 191 50 participants participant NNS cord-347946-i6kx3n6m 191 51 were be VBD cord-347946-i6kx3n6m 191 52 infected infect VBN cord-347946-i6kx3n6m 191 53 with with IN cord-347946-i6kx3n6m 191 54 malaria malaria NN cord-347946-i6kx3n6m 191 55 ; ; : cord-347946-i6kx3n6m 191 56 May May MD cord-347946-i6kx3n6m 191 57 et et NNP cord-347946-i6kx3n6m 191 58 al al NNP cord-347946-i6kx3n6m 191 59 , , , cord-347946-i6kx3n6m 191 60 2009 2009 CD cord-347946-i6kx3n6m 191 61 ) ) -RRB- cord-347946-i6kx3n6m 191 62 , , , cord-347946-i6kx3n6m 191 63 suggesting suggest VBG cord-347946-i6kx3n6m 191 64 that that IN cord-347946-i6kx3n6m 191 65 increased increase VBN cord-347946-i6kx3n6m 191 66 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 191 67 cytokine cytokine NN cord-347946-i6kx3n6m 191 68 production production NN cord-347946-i6kx3n6m 191 69 - - : cord-347946-i6kx3n6m 191 70 as as IN cord-347946-i6kx3n6m 191 71 observed observe VBN cord-347946-i6kx3n6m 191 72 in in IN cord-347946-i6kx3n6m 191 73 MDD MDD NNP cord-347946-i6kx3n6m 191 74 - - HYPH cord-347946-i6kx3n6m 191 75 promotes promote VBZ cord-347946-i6kx3n6m 191 76 survival survival NN cord-347946-i6kx3n6m 191 77 under under IN cord-347946-i6kx3n6m 191 78 conditions condition NNS cord-347946-i6kx3n6m 191 79 of of IN cord-347946-i6kx3n6m 191 80 high high JJ cord-347946-i6kx3n6m 191 81 - - HYPH cord-347946-i6kx3n6m 191 82 pathogen pathogen NN cord-347946-i6kx3n6m 191 83 burden burden NN cord-347946-i6kx3n6m 191 84 ( ( -LRB- cord-347946-i6kx3n6m 191 85 Drenos Drenos NNP cord-347946-i6kx3n6m 191 86 et et NNP cord-347946-i6kx3n6m 191 87 al al NNP cord-347946-i6kx3n6m 191 88 , , , cord-347946-i6kx3n6m 191 89 2006 2006 CD cord-347946-i6kx3n6m 191 90 ) ) -RRB- cord-347946-i6kx3n6m 191 91 . . . cord-347946-i6kx3n6m 192 1 More more RBR cord-347946-i6kx3n6m 192 2 definitive definitive JJ cord-347946-i6kx3n6m 192 3 evidence evidence NN cord-347946-i6kx3n6m 192 4 for for IN cord-347946-i6kx3n6m 192 5 this this DT cord-347946-i6kx3n6m 192 6 possibility possibility NN cord-347946-i6kx3n6m 192 7 comes come VBZ cord-347946-i6kx3n6m 192 8 from from IN cord-347946-i6kx3n6m 192 9 a a DT cord-347946-i6kx3n6m 192 10 second second JJ cord-347946-i6kx3n6m 192 11 Ghanian ghanian JJ cord-347946-i6kx3n6m 192 12 study study NN cord-347946-i6kx3n6m 192 13 that that IN cord-347946-i6kx3n6m 192 14 more more RBR cord-347946-i6kx3n6m 192 15 directly directly RB cord-347946-i6kx3n6m 192 16 examined examine VBN cord-347946-i6kx3n6m 192 17 the the DT cord-347946-i6kx3n6m 192 18 impact impact NN cord-347946-i6kx3n6m 192 19 of of IN cord-347946-i6kx3n6m 192 20 pathogen pathogen NN cord-347946-i6kx3n6m 192 21 exposure exposure NN cord-347946-i6kx3n6m 192 22 on on IN cord-347946-i6kx3n6m 192 23 the the DT cord-347946-i6kx3n6m 192 24 association association NN cord-347946-i6kx3n6m 192 25 between between IN cord-347946-i6kx3n6m 192 26 inflammation inflammation NN cord-347946-i6kx3n6m 192 27 and and CC cord-347946-i6kx3n6m 192 28 survival survival NN cord-347946-i6kx3n6m 192 29 . . . cord-347946-i6kx3n6m 193 1 Ghana Ghana NNP cord-347946-i6kx3n6m 193 2 is be VBZ cord-347946-i6kx3n6m 193 3 a a DT cord-347946-i6kx3n6m 193 4 country country NN cord-347946-i6kx3n6m 193 5 in in IN cord-347946-i6kx3n6m 193 6 which which WDT cord-347946-i6kx3n6m 193 7 some some DT cord-347946-i6kx3n6m 193 8 regions region NNS cord-347946-i6kx3n6m 193 9 have have VBP cord-347946-i6kx3n6m 193 10 pure pure JJ cord-347946-i6kx3n6m 193 11 water water NN cord-347946-i6kx3n6m 193 12 available available JJ cord-347946-i6kx3n6m 193 13 from from IN cord-347946-i6kx3n6m 193 14 boreholes borehole NNS cord-347946-i6kx3n6m 193 15 , , , cord-347946-i6kx3n6m 193 16 whereas whereas IN cord-347946-i6kx3n6m 193 17 other other JJ cord-347946-i6kx3n6m 193 18 regions region NNS cord-347946-i6kx3n6m 193 19 must must MD cord-347946-i6kx3n6m 193 20 rely rely VB cord-347946-i6kx3n6m 193 21 on on IN cord-347946-i6kx3n6m 193 22 heavily heavily RB cord-347946-i6kx3n6m 193 23 contaminated contaminate VBN cord-347946-i6kx3n6m 193 24 rivers river NNS cord-347946-i6kx3n6m 193 25 for for IN cord-347946-i6kx3n6m 193 26 drinking drinking NN cord-347946-i6kx3n6m 193 27 water water NN cord-347946-i6kx3n6m 193 28 . . . cord-347946-i6kx3n6m 194 1 As as IN cord-347946-i6kx3n6m 194 2 would would MD cord-347946-i6kx3n6m 194 3 be be VB cord-347946-i6kx3n6m 194 4 expected expect VBN cord-347946-i6kx3n6m 194 5 , , , cord-347946-i6kx3n6m 194 6 death death NN cord-347946-i6kx3n6m 194 7 rates rate NNS cord-347946-i6kx3n6m 194 8 from from IN cord-347946-i6kx3n6m 194 9 infection infection NN cord-347946-i6kx3n6m 194 10 are be VBP cord-347946-i6kx3n6m 194 11 far far RB cord-347946-i6kx3n6m 194 12 higher high JJR cord-347946-i6kx3n6m 194 13 in in IN cord-347946-i6kx3n6m 194 14 regions region NNS cord-347946-i6kx3n6m 194 15 that that WDT cord-347946-i6kx3n6m 194 16 utilize utilize VBP cord-347946-i6kx3n6m 194 17 rivers river NNS cord-347946-i6kx3n6m 194 18 than than IN cord-347946-i6kx3n6m 194 19 in in IN cord-347946-i6kx3n6m 194 20 areas area NNS cord-347946-i6kx3n6m 194 21 where where WRB cord-347946-i6kx3n6m 194 22 borehole borehole NN cord-347946-i6kx3n6m 194 23 - - HYPH cord-347946-i6kx3n6m 194 24 obtained obtain VBN cord-347946-i6kx3n6m 194 25 water water NN cord-347946-i6kx3n6m 194 26 is be VBZ cord-347946-i6kx3n6m 194 27 available available JJ cord-347946-i6kx3n6m 194 28 . . . cord-347946-i6kx3n6m 195 1 Consistent consistent JJ cord-347946-i6kx3n6m 195 2 with with IN cord-347946-i6kx3n6m 195 3 the the DT cord-347946-i6kx3n6m 195 4 prediction prediction NN cord-347946-i6kx3n6m 195 5 that that WDT cord-347946-i6kx3n6m 195 6 increased increase VBD cord-347946-i6kx3n6m 195 7 inflammatory inflammatory JJ cord-347946-i6kx3n6m 195 8 signaling signaling NN cord-347946-i6kx3n6m 195 9 is be VBZ cord-347946-i6kx3n6m 195 10 protective protective JJ cord-347946-i6kx3n6m 195 11 in in IN cord-347946-i6kx3n6m 195 12 the the DT cord-347946-i6kx3n6m 195 13 high high JJ cord-347946-i6kx3n6m 195 14 - - HYPH cord-347946-i6kx3n6m 195 15 infection infection NN cord-347946-i6kx3n6m 195 16 environments environment NNS cord-347946-i6kx3n6m 195 17 that that WDT cord-347946-i6kx3n6m 195 18 were be VBD cord-347946-i6kx3n6m 195 19 common common JJ cord-347946-i6kx3n6m 195 20 during during IN cord-347946-i6kx3n6m 195 21 human human JJ cord-347946-i6kx3n6m 195 22 evolution evolution NN cord-347946-i6kx3n6m 195 23 ( ( -LRB- cord-347946-i6kx3n6m 195 24 and and CC cord-347946-i6kx3n6m 195 25 especially especially RB cord-347946-i6kx3n6m 195 26 common common JJ cord-347946-i6kx3n6m 195 27 since since IN cord-347946-i6kx3n6m 195 28 the the DT cord-347946-i6kx3n6m 195 29 origin origin NN cord-347946-i6kx3n6m 195 30 of of IN cord-347946-i6kx3n6m 195 31 agriculture agriculture NN cord-347946-i6kx3n6m 195 32 and and CC cord-347946-i6kx3n6m 195 33 the the DT cord-347946-i6kx3n6m 195 34 rise rise NN cord-347946-i6kx3n6m 195 35 of of IN cord-347946-i6kx3n6m 195 36 cities city NNS cord-347946-i6kx3n6m 195 37 ; ; : cord-347946-i6kx3n6m 195 38 Armelagos Armelagos NNP cord-347946-i6kx3n6m 195 39 et et NNP cord-347946-i6kx3n6m 195 40 al al NNP cord-347946-i6kx3n6m 195 41 , , , cord-347946-i6kx3n6m 195 42 2005 2005 CD cord-347946-i6kx3n6m 195 43 ) ) -RRB- cord-347946-i6kx3n6m 195 44 , , , cord-347946-i6kx3n6m 195 45 a a DT cord-347946-i6kx3n6m 195 46 haplotype haplotype NN cord-347946-i6kx3n6m 195 47 of of IN cord-347946-i6kx3n6m 195 48 the the DT cord-347946-i6kx3n6m 195 49 IL-10 IL-10 NNP cord-347946-i6kx3n6m 195 50 gene gene NN cord-347946-i6kx3n6m 195 51 associated associate VBN cord-347946-i6kx3n6m 195 52 with with IN cord-347946-i6kx3n6m 195 53 increased increase VBN cord-347946-i6kx3n6m 195 54 inflammation inflammation NN cord-347946-i6kx3n6m 195 55 was be VBD cord-347946-i6kx3n6m 195 56 found find VBN cord-347946-i6kx3n6m 195 57 to to TO cord-347946-i6kx3n6m 195 58 be be VB cord-347946-i6kx3n6m 195 59 significantly significantly RB cord-347946-i6kx3n6m 195 60 more more RBR cord-347946-i6kx3n6m 195 61 prevalent prevalent JJ cord-347946-i6kx3n6m 195 62 in in IN cord-347946-i6kx3n6m 195 63 populations population NNS cord-347946-i6kx3n6m 195 64 that that WDT cord-347946-i6kx3n6m 195 65 relied rely VBD cord-347946-i6kx3n6m 195 66 on on IN cord-347946-i6kx3n6m 195 67 river river NN cord-347946-i6kx3n6m 195 68 water water NN cord-347946-i6kx3n6m 195 69 than than IN cord-347946-i6kx3n6m 195 70 in in IN cord-347946-i6kx3n6m 195 71 populations population NNS cord-347946-i6kx3n6m 195 72 that that WDT cord-347946-i6kx3n6m 195 73 drank drink VBD cord-347946-i6kx3n6m 195 74 from from IN cord-347946-i6kx3n6m 195 75 boreholes borehole NNS cord-347946-i6kx3n6m 195 76 - - HYPH cord-347946-i6kx3n6m 195 77 suggesting suggest VBG cord-347946-i6kx3n6m 195 78 positive positive JJ cord-347946-i6kx3n6m 195 79 selection selection NN cord-347946-i6kx3n6m 195 80 driven drive VBN cord-347946-i6kx3n6m 195 81 by by IN cord-347946-i6kx3n6m 195 82 enhanced enhanced JJ cord-347946-i6kx3n6m 195 83 pathogen pathogen NN cord-347946-i6kx3n6m 195 84 protection protection NN cord-347946-i6kx3n6m 195 85 ( ( -LRB- cord-347946-i6kx3n6m 195 86 Kuningas Kuningas NNP cord-347946-i6kx3n6m 195 87 et et NNP cord-347946-i6kx3n6m 195 88 al al NNP cord-347946-i6kx3n6m 195 89 , , , cord-347946-i6kx3n6m 195 90 2009 2009 CD cord-347946-i6kx3n6m 195 91 ) ) -RRB- cord-347946-i6kx3n6m 195 92 . . . cord-347946-i6kx3n6m 196 1 Consistent consistent JJ cord-347946-i6kx3n6m 196 2 with with IN cord-347946-i6kx3n6m 196 3 this this DT cord-347946-i6kx3n6m 196 4 possibility possibility NN cord-347946-i6kx3n6m 196 5 , , , cord-347946-i6kx3n6m 196 6 during during IN cord-347946-i6kx3n6m 196 7 a a DT cord-347946-i6kx3n6m 196 8 fiveyear fiveyear JJ cord-347946-i6kx3n6m 196 9 follow follow NN cord-347946-i6kx3n6m 196 10 - - HYPH cord-347946-i6kx3n6m 196 11 up up NN cord-347946-i6kx3n6m 196 12 period period NN cord-347946-i6kx3n6m 196 13 , , , cord-347946-i6kx3n6m 196 14 the the DT cord-347946-i6kx3n6m 196 15 high high JJ cord-347946-i6kx3n6m 196 16 - - HYPH cord-347946-i6kx3n6m 196 17 inflammation inflammation NN cord-347946-i6kx3n6m 196 18 IL-10 IL-10 NNP cord-347946-i6kx3n6m 196 19 haplotype haplotype NN cord-347946-i6kx3n6m 196 20 was be VBD cord-347946-i6kx3n6m 196 21 associated associate VBN cord-347946-i6kx3n6m 196 22 with with IN cord-347946-i6kx3n6m 196 23 reduced reduce VBN cord-347946-i6kx3n6m 196 24 survival survival NN cord-347946-i6kx3n6m 196 25 in in IN cord-347946-i6kx3n6m 196 26 individuals individual NNS cord-347946-i6kx3n6m 196 27 who who WP cord-347946-i6kx3n6m 196 28 drank drink VBD cord-347946-i6kx3n6m 196 29 clean clean JJ cord-347946-i6kx3n6m 196 30 water water NN cord-347946-i6kx3n6m 196 31 from from IN cord-347946-i6kx3n6m 196 32 boreholes borehole NNS cord-347946-i6kx3n6m 196 33 , , , cord-347946-i6kx3n6m 196 34 but but CC cord-347946-i6kx3n6m 196 35 increased increase VBN cord-347946-i6kx3n6m 196 36 survival survival NN cord-347946-i6kx3n6m 196 37 in in IN cord-347946-i6kx3n6m 196 38 populations population NNS cord-347946-i6kx3n6m 196 39 exposed expose VBN cord-347946-i6kx3n6m 196 40 to to IN cord-347946-i6kx3n6m 196 41 high high JJ cord-347946-i6kx3n6m 196 42 levels level NNS cord-347946-i6kx3n6m 196 43 of of IN cord-347946-i6kx3n6m 196 44 pathogens pathogen NNS cord-347946-i6kx3n6m 196 45 as as IN cord-347946-i6kx3n6m 196 46 a a DT cord-347946-i6kx3n6m 196 47 result result NN cord-347946-i6kx3n6m 196 48 of of IN cord-347946-i6kx3n6m 196 49 drinking drink VBG cord-347946-i6kx3n6m 196 50 river river NN cord-347946-i6kx3n6m 196 51 water water NN cord-347946-i6kx3n6m 196 52 ( ( -LRB- cord-347946-i6kx3n6m 196 53 Kuningas Kuningas NNP cord-347946-i6kx3n6m 196 54 et et NNP cord-347946-i6kx3n6m 196 55 al al NNP cord-347946-i6kx3n6m 196 56 , , , cord-347946-i6kx3n6m 196 57 2009 2009 CD cord-347946-i6kx3n6m 196 58 ) ) -RRB- cord-347946-i6kx3n6m 196 59 . . . cord-347946-i6kx3n6m 197 1 We -PRON- PRP cord-347946-i6kx3n6m 197 2 have have VBP cord-347946-i6kx3n6m 197 3 already already RB cord-347946-i6kx3n6m 197 4 noted note VBN cord-347946-i6kx3n6m 197 5 that that IN cord-347946-i6kx3n6m 197 6 depression depression NN cord-347946-i6kx3n6m 197 7 is be VBZ cord-347946-i6kx3n6m 197 8 associated associate VBN cord-347946-i6kx3n6m 197 9 with with IN cord-347946-i6kx3n6m 197 10 increased increase VBN cord-347946-i6kx3n6m 197 11 circulating circulate VBG cord-347946-i6kx3n6m 197 12 inflammatory inflammatory JJ cord-347946-i6kx3n6m 197 13 biomarkers biomarker NNS cord-347946-i6kx3n6m 197 14 in in IN cord-347946-i6kx3n6m 197 15 the the DT cord-347946-i6kx3n6m 197 16 forager forager NN cord-347946-i6kx3n6m 197 17 - - HYPH cord-347946-i6kx3n6m 197 18 horticulturist horticulturist NN cord-347946-i6kx3n6m 197 19 Tsimane Tsimane NNP cord-347946-i6kx3n6m 197 20 people people NNS cord-347946-i6kx3n6m 197 21 of of IN cord-347946-i6kx3n6m 197 22 lowland lowland NN cord-347946-i6kx3n6m 197 23 Bolivia Bolivia NNP cord-347946-i6kx3n6m 197 24 ( ( -LRB- cord-347946-i6kx3n6m 197 25 see see VB cord-347946-i6kx3n6m 197 26 Prediction Prediction NNP cord-347946-i6kx3n6m 197 27 3 3 CD cord-347946-i6kx3n6m 197 28 ) ) -RRB- cord-347946-i6kx3n6m 197 29 . . . cord-347946-i6kx3n6m 198 1 Researchers researcher NNS cord-347946-i6kx3n6m 198 2 also also RB cord-347946-i6kx3n6m 198 3 conducted conduct VBD cord-347946-i6kx3n6m 198 4 ex ex FW cord-347946-i6kx3n6m 198 5 vivo vivo NN cord-347946-i6kx3n6m 198 6 stimulation stimulation NN cord-347946-i6kx3n6m 198 7 studies study NNS cord-347946-i6kx3n6m 198 8 with with IN cord-347946-i6kx3n6m 198 9 endotoxin endotoxin NN cord-347946-i6kx3n6m 198 10 and and CC cord-347946-i6kx3n6m 198 11 phytohemagglutinin phytohemagglutinin NN cord-347946-i6kx3n6m 198 12 ( ( -LRB- cord-347946-i6kx3n6m 198 13 PHA PHA NNP cord-347946-i6kx3n6m 198 14 ; ; : cord-347946-i6kx3n6m 198 15 to to TO cord-347946-i6kx3n6m 198 16 assess assess VB cord-347946-i6kx3n6m 198 17 response response NN cord-347946-i6kx3n6m 198 18 capacity capacity NN cord-347946-i6kx3n6m 198 19 of of IN cord-347946-i6kx3n6m 198 20 both both CC cord-347946-i6kx3n6m 198 21 the the DT cord-347946-i6kx3n6m 198 22 innate innate NN cord-347946-i6kx3n6m 198 23 and and CC cord-347946-i6kx3n6m 198 24 acquired acquire VBD cord-347946-i6kx3n6m 198 25 immune immune JJ cord-347946-i6kx3n6m 198 26 systems system NNS cord-347946-i6kx3n6m 198 27 , , , cord-347946-i6kx3n6m 198 28 respectively respectively RB cord-347946-i6kx3n6m 198 29 ) ) -RRB- cord-347946-i6kx3n6m 198 30 and and CC cord-347946-i6kx3n6m 198 31 found find VBD cord-347946-i6kx3n6m 198 32 that that IN cord-347946-i6kx3n6m 198 33 Tsimane Tsimane NNP cord-347946-i6kx3n6m 198 34 individuals individual NNS cord-347946-i6kx3n6m 198 35 with with IN cord-347946-i6kx3n6m 198 36 high high JJ cord-347946-i6kx3n6m 198 37 levels level NNS cord-347946-i6kx3n6m 198 38 of of IN cord-347946-i6kx3n6m 198 39 depression depression NN cord-347946-i6kx3n6m 198 40 produced produce VBD cord-347946-i6kx3n6m 198 41 greater great JJR cord-347946-i6kx3n6m 198 42 levels level NNS cord-347946-i6kx3n6m 198 43 of of IN cord-347946-i6kx3n6m 198 44 IL-1-β IL-1-β NNP cord-347946-i6kx3n6m 198 45 , , , cord-347946-i6kx3n6m 198 46 IL-6 IL-6 NNP cord-347946-i6kx3n6m 198 47 , , , cord-347946-i6kx3n6m 198 48 and and CC cord-347946-i6kx3n6m 198 49 TNF TNF NNP cord-347946-i6kx3n6m 198 50 in in IN cord-347946-i6kx3n6m 198 51 response response NN cord-347946-i6kx3n6m 198 52 to to IN cord-347946-i6kx3n6m 198 53 both both DT cord-347946-i6kx3n6m 198 54 endotoxin endotoxin NN cord-347946-i6kx3n6m 198 55 and and CC cord-347946-i6kx3n6m 198 56 PHA PHA NNP cord-347946-i6kx3n6m 198 57 , , , cord-347946-i6kx3n6m 198 58 even even RB cord-347946-i6kx3n6m 198 59 when when WRB cord-347946-i6kx3n6m 198 60 excluding exclude VBG cord-347946-i6kx3n6m 198 61 individuals individual NNS cord-347946-i6kx3n6m 198 62 with with IN cord-347946-i6kx3n6m 198 63 leukocyte leukocyte NN cord-347946-i6kx3n6m 198 64 counts count VBZ cord-347946-i6kx3n6m 198 65 suggestive suggestive JJ cord-347946-i6kx3n6m 198 66 of of IN cord-347946-i6kx3n6m 198 67 current current JJ cord-347946-i6kx3n6m 198 68 infection infection NN cord-347946-i6kx3n6m 198 69 ( ( -LRB- cord-347946-i6kx3n6m 198 70 Stieglitz Stieglitz NNP cord-347946-i6kx3n6m 198 71 et et NNP cord-347946-i6kx3n6m 198 72 al al NNP cord-347946-i6kx3n6m 198 73 , , , cord-347946-i6kx3n6m 198 74 2015b 2015b CD cord-347946-i6kx3n6m 198 75 ) ) -RRB- cord-347946-i6kx3n6m 198 76 . . . cord-347946-i6kx3n6m 199 1 Interestingly interestingly RB cord-347946-i6kx3n6m 199 2 , , , cord-347946-i6kx3n6m 199 3 this this DT cord-347946-i6kx3n6m 199 4 pattern pattern NN cord-347946-i6kx3n6m 199 5 is be VBZ cord-347946-i6kx3n6m 199 6 different different JJ cord-347946-i6kx3n6m 199 7 from from IN cord-347946-i6kx3n6m 199 8 the the DT cord-347946-i6kx3n6m 199 9 suppression suppression NN cord-347946-i6kx3n6m 199 10 of of IN cord-347946-i6kx3n6m 199 11 mitogen mitogen NN cord-347946-i6kx3n6m 199 12 - - HYPH cord-347946-i6kx3n6m 199 13 stimulated stimulate VBN cord-347946-i6kx3n6m 199 14 immune immune JJ cord-347946-i6kx3n6m 199 15 responses response NNS cord-347946-i6kx3n6m 199 16 commonly commonly RB cord-347946-i6kx3n6m 199 17 observed observe VBD cord-347946-i6kx3n6m 199 18 in in IN cord-347946-i6kx3n6m 199 19 depressed depressed JJ cord-347946-i6kx3n6m 199 20 patients patient NNS cord-347946-i6kx3n6m 199 21 in in IN cord-347946-i6kx3n6m 199 22 the the DT cord-347946-i6kx3n6m 199 23 Western western JJ cord-347946-i6kx3n6m 199 24 world world NN cord-347946-i6kx3n6m 199 25 ( ( -LRB- cord-347946-i6kx3n6m 199 26 Herbert Herbert NNP cord-347946-i6kx3n6m 199 27 and and CC cord-347946-i6kx3n6m 199 28 Cohen Cohen NNP cord-347946-i6kx3n6m 199 29 , , , cord-347946-i6kx3n6m 199 30 1993a 1993a CD cord-347946-i6kx3n6m 199 31 ) ) -RRB- cord-347946-i6kx3n6m 199 32 , , , cord-347946-i6kx3n6m 199 33 which which WDT cord-347946-i6kx3n6m 199 34 may may MD cord-347946-i6kx3n6m 199 35 point point VB cord-347946-i6kx3n6m 199 36 to to IN cord-347946-i6kx3n6m 199 37 yet yet RB cord-347946-i6kx3n6m 199 38 another another DT cord-347946-i6kx3n6m 199 39 way way NN cord-347946-i6kx3n6m 199 40 in in IN cord-347946-i6kx3n6m 199 41 which which WDT cord-347946-i6kx3n6m 199 42 modern modern JJ cord-347946-i6kx3n6m 199 43 conditions condition NNS cord-347946-i6kx3n6m 199 44 have have VBP cord-347946-i6kx3n6m 199 45 disabled disable VBN cord-347946-i6kx3n6m 199 46 previously previously RB cord-347946-i6kx3n6m 199 47 adaptive adaptive JJ cord-347946-i6kx3n6m 199 48 associations association NNS cord-347946-i6kx3n6m 199 49 between between IN cord-347946-i6kx3n6m 199 50 depression depression NN cord-347946-i6kx3n6m 199 51 , , , cord-347946-i6kx3n6m 199 52 immune immune JJ cord-347946-i6kx3n6m 199 53 function function NN cord-347946-i6kx3n6m 199 54 , , , cord-347946-i6kx3n6m 199 55 and and CC cord-347946-i6kx3n6m 199 56 pathogen pathogen NN cord-347946-i6kx3n6m 199 57 - - HYPH cord-347946-i6kx3n6m 199 58 host host NN cord-347946-i6kx3n6m 199 59 defense defense NN cord-347946-i6kx3n6m 199 60 . . . cord-347946-i6kx3n6m 200 1 Nonetheless nonetheless RB cord-347946-i6kx3n6m 200 2 , , , cord-347946-i6kx3n6m 200 3 whether whether IN cord-347946-i6kx3n6m 200 4 the the DT cord-347946-i6kx3n6m 200 5 increased increase VBN cord-347946-i6kx3n6m 200 6 mitogen mitogen NN cord-347946-i6kx3n6m 200 7 - - HYPH cord-347946-i6kx3n6m 200 8 stimulated stimulate VBN cord-347946-i6kx3n6m 200 9 inflammatory inflammatory JJ cord-347946-i6kx3n6m 200 10 cytokine cytokine NN cord-347946-i6kx3n6m 200 11 response response NN cord-347946-i6kx3n6m 200 12 observed observe VBN cord-347946-i6kx3n6m 200 13 among among IN cord-347946-i6kx3n6m 200 14 depressed depressed JJ cord-347946-i6kx3n6m 200 15 members member NNS cord-347946-i6kx3n6m 200 16 of of IN cord-347946-i6kx3n6m 200 17 Tsimane Tsimane NNP cord-347946-i6kx3n6m 200 18 society society NN cord-347946-i6kx3n6m 200 19 would would MD cord-347946-i6kx3n6m 200 20 translate translate VB cord-347946-i6kx3n6m 200 21 to to IN cord-347946-i6kx3n6m 200 22 enhanced enhance VBN cord-347946-i6kx3n6m 200 23 protection protection NN cord-347946-i6kx3n6m 200 24 against against IN cord-347946-i6kx3n6m 200 25 pathogens pathogen NNS cord-347946-i6kx3n6m 200 26 remains remain VBZ cord-347946-i6kx3n6m 200 27 unknown unknown JJ cord-347946-i6kx3n6m 200 28 . . . cord-347946-i6kx3n6m 201 1 Multiple multiple JJ cord-347946-i6kx3n6m 201 2 facets facet NNS cord-347946-i6kx3n6m 201 3 of of IN cord-347946-i6kx3n6m 201 4 the the DT cord-347946-i6kx3n6m 201 5 modern modern JJ cord-347946-i6kx3n6m 201 6 world world NN cord-347946-i6kx3n6m 201 7 , , , cord-347946-i6kx3n6m 201 8 from from IN cord-347946-i6kx3n6m 201 9 antibiotics antibiotic NNS cord-347946-i6kx3n6m 201 10 to to IN cord-347946-i6kx3n6m 201 11 refrigeration refrigeration NN cord-347946-i6kx3n6m 201 12 and and CC cord-347946-i6kx3n6m 201 13 paved paved JJ cord-347946-i6kx3n6m 201 14 surfaces surface NNS cord-347946-i6kx3n6m 201 15 have have VBP cord-347946-i6kx3n6m 201 16 profoundly profoundly RB cord-347946-i6kx3n6m 201 17 reconfigured reconfigure VBN cord-347946-i6kx3n6m 201 18 our -PRON- PRP$ cord-347946-i6kx3n6m 201 19 relationship relationship NN cord-347946-i6kx3n6m 201 20 with with IN cord-347946-i6kx3n6m 201 21 the the DT cord-347946-i6kx3n6m 201 22 microbial microbial JJ cord-347946-i6kx3n6m 201 23 world world NN cord-347946-i6kx3n6m 201 24 in in IN cord-347946-i6kx3n6m 201 25 ways way NNS cord-347946-i6kx3n6m 201 26 that that WDT cord-347946-i6kx3n6m 201 27 have have VBP cord-347946-i6kx3n6m 201 28 reduced reduce VBN cord-347946-i6kx3n6m 201 29 the the DT cord-347946-i6kx3n6m 201 30 benefits benefit NNS cord-347946-i6kx3n6m 201 31 of of IN cord-347946-i6kx3n6m 201 32 inflammation inflammation NN cord-347946-i6kx3n6m 201 33 and and CC cord-347946-i6kx3n6m 201 34 increased increase VBD cord-347946-i6kx3n6m 201 35 its -PRON- PRP$ cord-347946-i6kx3n6m 201 36 costs cost NNS cord-347946-i6kx3n6m 201 37 ( ( -LRB- cord-347946-i6kx3n6m 201 38 Drenos Drenos NNP cord-347946-i6kx3n6m 201 39 et et NNP cord-347946-i6kx3n6m 201 40 al al NNP cord-347946-i6kx3n6m 201 41 , , , cord-347946-i6kx3n6m 201 42 2006 2006 CD cord-347946-i6kx3n6m 201 43 ; ; : cord-347946-i6kx3n6m 201 44 Raison Raison NNP cord-347946-i6kx3n6m 201 45 et et NNP cord-347946-i6kx3n6m 201 46 al al NNP cord-347946-i6kx3n6m 201 47 , , , cord-347946-i6kx3n6m 201 48 2010c 2010c CD cord-347946-i6kx3n6m 201 49 ) ) -RRB- cord-347946-i6kx3n6m 201 50 . . . cord-347946-i6kx3n6m 202 1 Nonetheless nonetheless RB cord-347946-i6kx3n6m 202 2 , , , cord-347946-i6kx3n6m 202 3 even even RB cord-347946-i6kx3n6m 202 4 in in IN cord-347946-i6kx3n6m 202 5 an an DT cord-347946-i6kx3n6m 202 6 environment environment NN cord-347946-i6kx3n6m 202 7 so so RB cord-347946-i6kx3n6m 202 8 radically radically RB cord-347946-i6kx3n6m 202 9 different different JJ cord-347946-i6kx3n6m 202 10 from from IN cord-347946-i6kx3n6m 202 11 that that DT cord-347946-i6kx3n6m 202 12 in in IN cord-347946-i6kx3n6m 202 13 which which WDT cord-347946-i6kx3n6m 202 14 humans human NNS cord-347946-i6kx3n6m 202 15 evolved evolve VBD cord-347946-i6kx3n6m 202 16 , , , cord-347946-i6kx3n6m 202 17 data datum NNS cord-347946-i6kx3n6m 202 18 link link NN cord-347946-i6kx3n6m 202 19 increased increase VBN cord-347946-i6kx3n6m 202 20 inflammation inflammation NN cord-347946-i6kx3n6m 202 21 with with IN cord-347946-i6kx3n6m 202 22 improved improved JJ cord-347946-i6kx3n6m 202 23 outcome outcome NN cord-347946-i6kx3n6m 202 24 in in IN cord-347946-i6kx3n6m 202 25 the the DT cord-347946-i6kx3n6m 202 26 context context NN cord-347946-i6kx3n6m 202 27 of of IN cord-347946-i6kx3n6m 202 28 at at IN cord-347946-i6kx3n6m 202 29 least least JJS cord-347946-i6kx3n6m 202 30 some some DT cord-347946-i6kx3n6m 202 31 infections infection NNS cord-347946-i6kx3n6m 202 32 . . . cord-347946-i6kx3n6m 203 1 For for IN cord-347946-i6kx3n6m 203 2 example example NN cord-347946-i6kx3n6m 203 3 , , , cord-347946-i6kx3n6m 203 4 in in IN cord-347946-i6kx3n6m 203 5 a a DT cord-347946-i6kx3n6m 203 6 large large JJ cord-347946-i6kx3n6m 203 7 study study NN cord-347946-i6kx3n6m 203 8 of of IN cord-347946-i6kx3n6m 203 9 consecutive consecutive JJ cord-347946-i6kx3n6m 203 10 patients patient NNS cord-347946-i6kx3n6m 203 11 admitted admit VBN cord-347946-i6kx3n6m 203 12 to to IN cord-347946-i6kx3n6m 203 13 hospital hospital NN cord-347946-i6kx3n6m 203 14 with with IN cord-347946-i6kx3n6m 203 15 fever fever NN cord-347946-i6kx3n6m 203 16 , , , cord-347946-i6kx3n6m 203 17 elevations elevation NNS cord-347946-i6kx3n6m 203 18 in in IN cord-347946-i6kx3n6m 203 19 plasma plasma NN cord-347946-i6kx3n6m 203 20 concentrations concentration NNS cord-347946-i6kx3n6m 203 21 of of IN cord-347946-i6kx3n6m 203 22 the the DT cord-347946-i6kx3n6m 203 23 anti anti JJ cord-347946-i6kx3n6m 203 24 - - JJ cord-347946-i6kx3n6m 203 25 inflammatory inflammatory JJ cord-347946-i6kx3n6m 203 26 cytokine cytokine NN cord-347946-i6kx3n6m 203 27 IL-10-as il-10-as NN cord-347946-i6kx3n6m 203 28 well well RB cord-347946-i6kx3n6m 203 29 as as IN cord-347946-i6kx3n6m 203 30 the the DT cord-347946-i6kx3n6m 203 31 ratio ratio NN cord-347946-i6kx3n6m 203 32 of of IN cord-347946-i6kx3n6m 203 33 IL-10 IL-10 NNP cord-347946-i6kx3n6m 203 34 / / SYM cord-347946-i6kx3n6m 203 35 TNF TNF NNP cord-347946-i6kx3n6m 203 36 - - HYPH cord-347946-i6kx3n6m 203 37 α α NNP cord-347946-i6kx3n6m 203 38 - - , cord-347946-i6kx3n6m 203 39 were be VBD cord-347946-i6kx3n6m 203 40 associated associate VBN cord-347946-i6kx3n6m 203 41 with with IN cord-347946-i6kx3n6m 203 42 increased increase VBN cord-347946-i6kx3n6m 203 43 mortality mortality NN cord-347946-i6kx3n6m 203 44 ( ( -LRB- cord-347946-i6kx3n6m 203 45 van van NNP cord-347946-i6kx3n6m 203 46 Dissel Dissel NNP cord-347946-i6kx3n6m 203 47 et et FW cord-347946-i6kx3n6m 203 48 al al NNP cord-347946-i6kx3n6m 203 49 , , , cord-347946-i6kx3n6m 203 50 1998 1998 CD cord-347946-i6kx3n6m 203 51 ) ) -RRB- cord-347946-i6kx3n6m 203 52 and and CC cord-347946-i6kx3n6m 203 53 increased increase VBN cord-347946-i6kx3n6m 203 54 IL-10 IL-10 NNP cord-347946-i6kx3n6m 203 55 production production NN cord-347946-i6kx3n6m 203 56 late late RB cord-347946-i6kx3n6m 203 57 in in IN cord-347946-i6kx3n6m 203 58 the the DT cord-347946-i6kx3n6m 203 59 disease disease NN cord-347946-i6kx3n6m 203 60 course course NN cord-347946-i6kx3n6m 203 61 predicted predict VBD cord-347946-i6kx3n6m 203 62 reduced reduced JJ cord-347946-i6kx3n6m 203 63 survival survival NN cord-347946-i6kx3n6m 203 64 following follow VBG cord-347946-i6kx3n6m 203 65 infection infection NN cord-347946-i6kx3n6m 203 66 with with IN cord-347946-i6kx3n6m 203 67 the the DT cord-347946-i6kx3n6m 203 68 pandemic pandemic NN cord-347946-i6kx3n6m 203 69 A A NNP cord-347946-i6kx3n6m 203 70 / / SYM cord-347946-i6kx3n6m 203 71 H1N1-/2009 H1N1-/2009 NNP cord-347946-i6kx3n6m 203 72 influenza influenza NN cord-347946-i6kx3n6m 203 73 virus virus NN cord-347946-i6kx3n6m 203 74 ( ( -LRB- cord-347946-i6kx3n6m 203 75 Bermejo Bermejo NNP cord-347946-i6kx3n6m 203 76 - - HYPH cord-347946-i6kx3n6m 203 77 Martin Martin NNP cord-347946-i6kx3n6m 203 78 et et NNP cord-347946-i6kx3n6m 203 79 al al NNP cord-347946-i6kx3n6m 203 80 , , , cord-347946-i6kx3n6m 203 81 2010 2010 CD cord-347946-i6kx3n6m 203 82 ) ) -RRB- cord-347946-i6kx3n6m 203 83 . . . cord-347946-i6kx3n6m 204 1 As as IN cord-347946-i6kx3n6m 204 2 these these DT cord-347946-i6kx3n6m 204 3 findings finding NNS cord-347946-i6kx3n6m 204 4 would would MD cord-347946-i6kx3n6m 204 5 predict predict VB cord-347946-i6kx3n6m 204 6 , , , cord-347946-i6kx3n6m 204 7 alleles allele NNS cord-347946-i6kx3n6m 204 8 of of IN cord-347946-i6kx3n6m 204 9 the the DT cord-347946-i6kx3n6m 204 10 IL-10 IL-10 NNP cord-347946-i6kx3n6m 204 11 gene gene NN cord-347946-i6kx3n6m 204 12 - - , cord-347946-i6kx3n6m 204 13 such such JJ cord-347946-i6kx3n6m 204 14 as as IN cord-347946-i6kx3n6m 204 15 -1082G -1082g NN cord-347946-i6kx3n6m 204 16 - - HYPH cord-347946-i6kx3n6m 204 17 associated associate VBN cord-347946-i6kx3n6m 204 18 with with IN cord-347946-i6kx3n6m 204 19 higher high JJR cord-347946-i6kx3n6m 204 20 IL-10 IL-10 NNP cord-347946-i6kx3n6m 204 21 production production NN cord-347946-i6kx3n6m 204 22 appear appear VBP cord-347946-i6kx3n6m 204 23 to to TO cord-347946-i6kx3n6m 204 24 promulgate promulgate VB cord-347946-i6kx3n6m 204 25 poor poor JJ cord-347946-i6kx3n6m 204 26 infectious infectious JJ cord-347946-i6kx3n6m 204 27 outcomes outcome NNS cord-347946-i6kx3n6m 204 28 . . . cord-347946-i6kx3n6m 205 1 For for IN cord-347946-i6kx3n6m 205 2 example example NN cord-347946-i6kx3n6m 205 3 , , , cord-347946-i6kx3n6m 205 4 the the DT cord-347946-i6kx3n6m 205 5 − − CD cord-347946-i6kx3n6m 205 6 1082 1082 CD cord-347946-i6kx3n6m 206 1 G g NN cord-347946-i6kx3n6m 206 2 allele allele NN cord-347946-i6kx3n6m 206 3 predicts predict VBZ cord-347946-i6kx3n6m 206 4 increased increase VBN cord-347946-i6kx3n6m 206 5 symptom symptom NN cord-347946-i6kx3n6m 206 6 severity severity NN cord-347946-i6kx3n6m 206 7 and and CC cord-347946-i6kx3n6m 206 8 mortality mortality NN cord-347946-i6kx3n6m 206 9 in in IN cord-347946-i6kx3n6m 206 10 the the DT cord-347946-i6kx3n6m 206 11 context context NN cord-347946-i6kx3n6m 206 12 of of IN cord-347946-i6kx3n6m 206 13 community community NN cord-347946-i6kx3n6m 206 14 acquired acquire VBN cord-347946-i6kx3n6m 206 15 pneumonia pneumonia NN cord-347946-i6kx3n6m 206 16 ( ( -LRB- cord-347946-i6kx3n6m 206 17 Gallagher Gallagher NNP cord-347946-i6kx3n6m 206 18 et et NNP cord-347946-i6kx3n6m 206 19 al al NNP cord-347946-i6kx3n6m 206 20 , , , cord-347946-i6kx3n6m 206 21 2003 2003 CD cord-347946-i6kx3n6m 206 22 ) ) -RRB- cord-347946-i6kx3n6m 206 23 and and CC cord-347946-i6kx3n6m 206 24 is be VBZ cord-347946-i6kx3n6m 206 25 associated associate VBN cord-347946-i6kx3n6m 206 26 with with IN cord-347946-i6kx3n6m 206 27 reduced reduce VBN cord-347946-i6kx3n6m 206 28 antibody antibody NN cord-347946-i6kx3n6m 206 29 responses response NNS cord-347946-i6kx3n6m 206 30 to to IN cord-347946-i6kx3n6m 206 31 tetanus tetanus NN cord-347946-i6kx3n6m 206 32 , , , cord-347946-i6kx3n6m 206 33 influenza influenza NN cord-347946-i6kx3n6m 206 34 and and CC cord-347946-i6kx3n6m 206 35 hepatitis hepatitis NN cord-347946-i6kx3n6m 206 36 B B NNP cord-347946-i6kx3n6m 206 37 virus virus NN cord-347946-i6kx3n6m 206 38 ( ( -LRB- cord-347946-i6kx3n6m 206 39 HBV HBV NNP cord-347946-i6kx3n6m 206 40 ) ) -RRB- cord-347946-i6kx3n6m 206 41 vaccines vaccine NNS cord-347946-i6kx3n6m 206 42 ( ( -LRB- cord-347946-i6kx3n6m 206 43 Hohler Hohler NNP cord-347946-i6kx3n6m 206 44 et et NNP cord-347946-i6kx3n6m 206 45 al al NNP cord-347946-i6kx3n6m 206 46 , , , cord-347946-i6kx3n6m 206 47 2005 2005 CD cord-347946-i6kx3n6m 206 48 ; ; : cord-347946-i6kx3n6m 206 49 Corsini Corsini NNP cord-347946-i6kx3n6m 206 50 et et NNP cord-347946-i6kx3n6m 206 51 al al NNP cord-347946-i6kx3n6m 206 52 , , , cord-347946-i6kx3n6m 206 53 2006 2006 CD cord-347946-i6kx3n6m 206 54 ; ; : cord-347946-i6kx3n6m 206 55 Li Li NNP cord-347946-i6kx3n6m 206 56 et et NNP cord-347946-i6kx3n6m 206 57 al al NNP cord-347946-i6kx3n6m 206 58 , , , cord-347946-i6kx3n6m 206 59 2007 2007 CD cord-347946-i6kx3n6m 206 60 ) ) -RRB- cord-347946-i6kx3n6m 206 61 . . . cord-347946-i6kx3n6m 207 1 Families family NNS cord-347946-i6kx3n6m 207 2 with with IN cord-347946-i6kx3n6m 207 3 a a DT cord-347946-i6kx3n6m 207 4 member member NN cord-347946-i6kx3n6m 207 5 who who WP cord-347946-i6kx3n6m 207 6 died die VBD cord-347946-i6kx3n6m 207 7 from from IN cord-347946-i6kx3n6m 207 8 meningococcal meningococcal JJ cord-347946-i6kx3n6m 207 9 disease disease NN cord-347946-i6kx3n6m 207 10 were be VBD cord-347946-i6kx3n6m 207 11 characterized characterize VBN cord-347946-i6kx3n6m 207 12 by by IN cord-347946-i6kx3n6m 207 13 increased increase VBN cord-347946-i6kx3n6m 207 14 production production NN cord-347946-i6kx3n6m 207 15 of of IN cord-347946-i6kx3n6m 207 16 IL-10 IL-10 NNP cord-347946-i6kx3n6m 207 17 and and CC cord-347946-i6kx3n6m 207 18 reduced reduce VBN cord-347946-i6kx3n6m 207 19 production production NN cord-347946-i6kx3n6m 207 20 of of IN cord-347946-i6kx3n6m 207 21 TNF TNF NNP cord-347946-i6kx3n6m 207 22 - - HYPH cord-347946-i6kx3n6m 207 23 α α NNP cord-347946-i6kx3n6m 207 24 when when WRB cord-347946-i6kx3n6m 207 25 compared compare VBN cord-347946-i6kx3n6m 207 26 with with IN cord-347946-i6kx3n6m 207 27 families family NNS cord-347946-i6kx3n6m 207 28 with with IN cord-347946-i6kx3n6m 207 29 a a DT cord-347946-i6kx3n6m 207 30 member member NN cord-347946-i6kx3n6m 207 31 who who WP cord-347946-i6kx3n6m 207 32 had have VBD cord-347946-i6kx3n6m 207 33 bacterial bacterial JJ cord-347946-i6kx3n6m 207 34 meningitis meningitis NN cord-347946-i6kx3n6m 207 35 but but CC cord-347946-i6kx3n6m 207 36 survived survive VBD cord-347946-i6kx3n6m 207 37 ( ( -LRB- cord-347946-i6kx3n6m 207 38 Westendorp Westendorp NNP cord-347946-i6kx3n6m 207 39 et et NNP cord-347946-i6kx3n6m 207 40 al al NNP cord-347946-i6kx3n6m 207 41 , , , cord-347946-i6kx3n6m 207 42 1997 1997 CD cord-347946-i6kx3n6m 207 43 ) ) -RRB- cord-347946-i6kx3n6m 207 44 and and CC cord-347946-i6kx3n6m 207 45 elevated elevated JJ cord-347946-i6kx3n6m 207 46 CRP CRP NNP cord-347946-i6kx3n6m 207 47 has have VBZ cord-347946-i6kx3n6m 207 48 been be VBN cord-347946-i6kx3n6m 207 49 associated associate VBN cord-347946-i6kx3n6m 207 50 with with IN cord-347946-i6kx3n6m 207 51 increased increase VBN cord-347946-i6kx3n6m 207 52 survival survival NN cord-347946-i6kx3n6m 207 53 in in IN cord-347946-i6kx3n6m 207 54 children child NNS cord-347946-i6kx3n6m 207 55 with with IN cord-347946-i6kx3n6m 207 56 meningococcal meningococcal JJ cord-347946-i6kx3n6m 207 57 sepsis sepsis NN cord-347946-i6kx3n6m 208 1 ( ( -LRB- cord-347946-i6kx3n6m 208 2 Joosten Joosten NNP cord-347946-i6kx3n6m 208 3 et et NNP cord-347946-i6kx3n6m 208 4 al al NNP cord-347946-i6kx3n6m 208 5 , , , cord-347946-i6kx3n6m 208 6 2000 2000 CD cord-347946-i6kx3n6m 208 7 ) ) -RRB- cord-347946-i6kx3n6m 208 8 . . . cord-347946-i6kx3n6m 209 1 The the DT cord-347946-i6kx3n6m 209 2 IFN IFN NNP cord-347946-i6kx3n6m 209 3 - - HYPH cord-347946-i6kx3n6m 209 4 γ γ NNP cord-347946-i6kx3n6m 209 5 +874 +874 NNP cord-347946-i6kx3n6m 209 6 T T NNP cord-347946-i6kx3n6m 209 7 allele allele NN cord-347946-i6kx3n6m 209 8 increases increase VBZ cord-347946-i6kx3n6m 209 9 production production NN cord-347946-i6kx3n6m 209 10 of of IN cord-347946-i6kx3n6m 209 11 this this DT cord-347946-i6kx3n6m 209 12 Th1 th1 CD cord-347946-i6kx3n6m 209 13 inflammatory inflammatory JJ cord-347946-i6kx3n6m 209 14 cytokine cytokine NN cord-347946-i6kx3n6m 209 15 via via IN cord-347946-i6kx3n6m 209 16 enhanced enhance VBN cord-347946-i6kx3n6m 209 17 binding binding NN cord-347946-i6kx3n6m 209 18 of of IN cord-347946-i6kx3n6m 209 19 NFKB NFKB NNP cord-347946-i6kx3n6m 210 1 ( ( -LRB- cord-347946-i6kx3n6m 210 2 Pravica Pravica NNP cord-347946-i6kx3n6m 210 3 et et FW cord-347946-i6kx3n6m 210 4 al al NNP cord-347946-i6kx3n6m 210 5 , , , cord-347946-i6kx3n6m 210 6 1999 1999 CD cord-347946-i6kx3n6m 211 1 ( ( -LRB- cord-347946-i6kx3n6m 211 2 Pravica Pravica NNP cord-347946-i6kx3n6m 211 3 et et FW cord-347946-i6kx3n6m 211 4 al al NNP cord-347946-i6kx3n6m 211 5 , , , cord-347946-i6kx3n6m 211 6 , , , cord-347946-i6kx3n6m 211 7 2000 2000 CD cord-347946-i6kx3n6m 211 8 and and CC cord-347946-i6kx3n6m 211 9 protects protect VBZ cord-347946-i6kx3n6m 211 10 against against IN cord-347946-i6kx3n6m 211 11 Mediterranean Mediterranean NNP cord-347946-i6kx3n6m 211 12 Spotted spot VBN cord-347946-i6kx3n6m 211 13 fever fever NN cord-347946-i6kx3n6m 211 14 ( ( -LRB- cord-347946-i6kx3n6m 211 15 Forte Forte NNP cord-347946-i6kx3n6m 211 16 et et FW cord-347946-i6kx3n6m 211 17 al al NNP cord-347946-i6kx3n6m 211 18 , , , cord-347946-i6kx3n6m 211 19 2009 2009 CD cord-347946-i6kx3n6m 211 20 ) ) -RRB- cord-347946-i6kx3n6m 211 21 . . . cord-347946-i6kx3n6m 212 1 Multiple multiple JJ cord-347946-i6kx3n6m 212 2 studies study NNS cord-347946-i6kx3n6m 212 3 and and CC cord-347946-i6kx3n6m 212 4 a a DT cord-347946-i6kx3n6m 212 5 large large JJ cord-347946-i6kx3n6m 212 6 meta meta JJ cord-347946-i6kx3n6m 212 7 - - HYPH cord-347946-i6kx3n6m 212 8 analysis analysis NN cord-347946-i6kx3n6m 212 9 find find VBP cord-347946-i6kx3n6m 212 10 that that IN cord-347946-i6kx3n6m 212 11 the the DT cord-347946-i6kx3n6m 212 12 T T NNP cord-347946-i6kx3n6m 212 13 allele allele NN cord-347946-i6kx3n6m 212 14 also also RB cord-347946-i6kx3n6m 212 15 protects protect VBZ cord-347946-i6kx3n6m 212 16 against against IN cord-347946-i6kx3n6m 212 17 the the DT cord-347946-i6kx3n6m 212 18 development development NN cord-347946-i6kx3n6m 212 19 of of IN cord-347946-i6kx3n6m 212 20 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 212 21 on on IN cord-347946-i6kx3n6m 212 22 the the DT cord-347946-i6kx3n6m 212 23 individual individual NN cord-347946-i6kx3n6m 213 1 ( ( -LRB- cord-347946-i6kx3n6m 213 2 Pacheco Pacheco NNP cord-347946-i6kx3n6m 213 3 et et NNP cord-347946-i6kx3n6m 213 4 al al NNP cord-347946-i6kx3n6m 213 5 , , , cord-347946-i6kx3n6m 213 6 2008 2008 CD cord-347946-i6kx3n6m 213 7 ) ) -RRB- cord-347946-i6kx3n6m 213 8 and and CC cord-347946-i6kx3n6m 213 9 population population NN cord-347946-i6kx3n6m 213 10 levels level NNS cord-347946-i6kx3n6m 214 1 ( ( -LRB- cord-347946-i6kx3n6m 214 2 Larcombe Larcombe NNP cord-347946-i6kx3n6m 214 3 et et NNP cord-347946-i6kx3n6m 214 4 al al NNP cord-347946-i6kx3n6m 214 5 , , , cord-347946-i6kx3n6m 214 6 2008 2008 CD cord-347946-i6kx3n6m 214 7 ) ) -RRB- cord-347946-i6kx3n6m 214 8 . . . cord-347946-i6kx3n6m 215 1 In in IN cord-347946-i6kx3n6m 215 2 individuals individual NNS cord-347946-i6kx3n6m 215 3 with with IN cord-347946-i6kx3n6m 215 4 active active JJ cord-347946-i6kx3n6m 215 5 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 215 6 , , , cord-347946-i6kx3n6m 215 7 the the DT cord-347946-i6kx3n6m 215 8 T T NNP cord-347946-i6kx3n6m 215 9 allele allele NN cord-347946-i6kx3n6m 215 10 reduces reduce VBZ cord-347946-i6kx3n6m 215 11 severity severity NN cord-347946-i6kx3n6m 215 12 and and CC cord-347946-i6kx3n6m 215 13 risk risk NN cord-347946-i6kx3n6m 215 14 of of IN cord-347946-i6kx3n6m 215 15 disseminated disseminate VBN cord-347946-i6kx3n6m 215 16 disease disease NN cord-347946-i6kx3n6m 215 17 ( ( -LRB- cord-347946-i6kx3n6m 215 18 Ansari Ansari NNP cord-347946-i6kx3n6m 215 19 et et NNP cord-347946-i6kx3n6m 215 20 al al NNP cord-347946-i6kx3n6m 215 21 , , , cord-347946-i6kx3n6m 215 22 2009 2009 CD cord-347946-i6kx3n6m 215 23 ) ) -RRB- cord-347946-i6kx3n6m 215 24 . . . cord-347946-i6kx3n6m 216 1 The the DT cord-347946-i6kx3n6m 216 2 T T NNP cord-347946-i6kx3n6m 216 3 allele allele NN cord-347946-i6kx3n6m 216 4 also also RB cord-347946-i6kx3n6m 216 5 reduces reduce VBZ cord-347946-i6kx3n6m 216 6 the the DT cord-347946-i6kx3n6m 216 7 risk risk NN cord-347946-i6kx3n6m 216 8 of of IN cord-347946-i6kx3n6m 216 9 leprosy leprosy NN cord-347946-i6kx3n6m 216 10 ( ( -LRB- cord-347946-i6kx3n6m 216 11 Cardoso Cardoso NNP cord-347946-i6kx3n6m 216 12 et et NNP cord-347946-i6kx3n6m 216 13 al al NNP cord-347946-i6kx3n6m 216 14 , , , cord-347946-i6kx3n6m 216 15 2010 2010 CD cord-347946-i6kx3n6m 216 16 ) ) -RRB- cord-347946-i6kx3n6m 216 17 , , , cord-347946-i6kx3n6m 216 18 severe severe JJ cord-347946-i6kx3n6m 216 19 acute acute JJ cord-347946-i6kx3n6m 216 20 respiratory respiratory JJ cord-347946-i6kx3n6m 216 21 syndrome syndrome NN cord-347946-i6kx3n6m 216 22 ( ( -LRB- cord-347946-i6kx3n6m 216 23 SARS SARS NNP cord-347946-i6kx3n6m 216 24 ; ; : cord-347946-i6kx3n6m 216 25 Chong Chong NNP cord-347946-i6kx3n6m 216 26 et et NNP cord-347946-i6kx3n6m 216 27 al al NNP cord-347946-i6kx3n6m 216 28 , , , cord-347946-i6kx3n6m 216 29 2006 2006 CD cord-347946-i6kx3n6m 216 30 ) ) -RRB- cord-347946-i6kx3n6m 216 31 , , , cord-347946-i6kx3n6m 216 32 and and CC cord-347946-i6kx3n6m 216 33 Chagas Chagas NNP cord-347946-i6kx3n6m 216 34 disease disease NN cord-347946-i6kx3n6m 217 1 ( ( -LRB- cord-347946-i6kx3n6m 217 2 Torres Torres NNP cord-347946-i6kx3n6m 217 3 et et NNP cord-347946-i6kx3n6m 217 4 al al NNP cord-347946-i6kx3n6m 217 5 , , , cord-347946-i6kx3n6m 217 6 2010 2010 CD cord-347946-i6kx3n6m 217 7 ) ) -RRB- cord-347946-i6kx3n6m 217 8 . . . cord-347946-i6kx3n6m 218 1 Conversely conversely RB cord-347946-i6kx3n6m 218 2 , , , cord-347946-i6kx3n6m 218 3 the the DT cord-347946-i6kx3n6m 218 4 low low RB cord-347946-i6kx3n6m 218 5 - - HYPH cord-347946-i6kx3n6m 218 6 producing produce VBG cord-347946-i6kx3n6m 218 7 +825A +825a XX cord-347946-i6kx3n6m 218 8 allele allele NN cord-347946-i6kx3n6m 218 9 predisposes predispose VBZ cord-347946-i6kx3n6m 218 10 for for IN cord-347946-i6kx3n6m 218 11 hepatitis hepatitis NNP cord-347946-i6kx3n6m 218 12 B B NNP cord-347946-i6kx3n6m 218 13 and and CC cord-347946-i6kx3n6m 218 14 C C NNP cord-347946-i6kx3n6m 218 15 persistence persistence NN cord-347946-i6kx3n6m 218 16 and and CC cord-347946-i6kx3n6m 218 17 negatively negatively RB cord-347946-i6kx3n6m 218 18 impacts impact VBZ cord-347946-i6kx3n6m 218 19 clinical clinical JJ cord-347946-i6kx3n6m 218 20 course course NN cord-347946-i6kx3n6m 218 21 of of IN cord-347946-i6kx3n6m 218 22 the the DT cord-347946-i6kx3n6m 218 23 disease disease NN cord-347946-i6kx3n6m 218 24 ( ( -LRB- cord-347946-i6kx3n6m 218 25 Gao Gao NNP cord-347946-i6kx3n6m 218 26 et et NNP cord-347946-i6kx3n6m 218 27 al al NNP cord-347946-i6kx3n6m 218 28 , , , cord-347946-i6kx3n6m 218 29 2009 2009 CD cord-347946-i6kx3n6m 218 30 ) ) -RRB- cord-347946-i6kx3n6m 218 31 . . . cord-347946-i6kx3n6m 219 1 Consistent consistent JJ cord-347946-i6kx3n6m 219 2 with with IN cord-347946-i6kx3n6m 219 3 these these DT cord-347946-i6kx3n6m 219 4 findings finding NNS cord-347946-i6kx3n6m 219 5 , , , cord-347946-i6kx3n6m 219 6 reduced reduce VBD cord-347946-i6kx3n6m 219 7 peripheral peripheral JJ cord-347946-i6kx3n6m 219 8 blood blood NN cord-347946-i6kx3n6m 219 9 mononuclear mononuclear JJ cord-347946-i6kx3n6m 219 10 cell cell NN cord-347946-i6kx3n6m 219 11 production production NN cord-347946-i6kx3n6m 219 12 of of IN cord-347946-i6kx3n6m 219 13 IFN IFN NNP cord-347946-i6kx3n6m 219 14 - - HYPH cord-347946-i6kx3n6m 219 15 γ γ NNP cord-347946-i6kx3n6m 219 16 and and CC cord-347946-i6kx3n6m 219 17 IL-12 IL-12 NNP cord-347946-i6kx3n6m 219 18 is be VBZ cord-347946-i6kx3n6m 219 19 associated associate VBN cord-347946-i6kx3n6m 219 20 with with IN cord-347946-i6kx3n6m 219 21 increased increase VBN cord-347946-i6kx3n6m 219 22 severity severity NN cord-347946-i6kx3n6m 219 23 of of IN cord-347946-i6kx3n6m 219 24 respiratory respiratory JJ cord-347946-i6kx3n6m 219 25 syncytial syncytial JJ cord-347946-i6kx3n6m 219 26 virus virus NN cord-347946-i6kx3n6m 219 27 symptoms symptom NNS cord-347946-i6kx3n6m 219 28 in in IN cord-347946-i6kx3n6m 219 29 infants infant NNS cord-347946-i6kx3n6m 219 30 under under IN cord-347946-i6kx3n6m 219 31 one one CD cord-347946-i6kx3n6m 219 32 year year NN cord-347946-i6kx3n6m 219 33 of of IN cord-347946-i6kx3n6m 219 34 age age NN cord-347946-i6kx3n6m 219 35 ( ( -LRB- cord-347946-i6kx3n6m 219 36 Pinto Pinto NNP cord-347946-i6kx3n6m 219 37 et et NNP cord-347946-i6kx3n6m 219 38 al al NNP cord-347946-i6kx3n6m 219 39 , , , cord-347946-i6kx3n6m 219 40 2006 2006 CD cord-347946-i6kx3n6m 219 41 ) ) -RRB- cord-347946-i6kx3n6m 219 42 . . . cord-347946-i6kx3n6m 220 1 The the DT cord-347946-i6kx3n6m 220 2 association association NN cord-347946-i6kx3n6m 220 3 of of IN cord-347946-i6kx3n6m 220 4 depression depression NN cord-347946-i6kx3n6m 220 5 with with IN cord-347946-i6kx3n6m 220 6 increased increase VBN cord-347946-i6kx3n6m 220 7 circulating circulate VBG cord-347946-i6kx3n6m 220 8 levels level NNS cord-347946-i6kx3n6m 220 9 of of IN cord-347946-i6kx3n6m 220 10 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 220 11 cytokines cytokine NNS cord-347946-i6kx3n6m 220 12 and and CC cord-347946-i6kx3n6m 220 13 CRP CRP NNP cord-347946-i6kx3n6m 220 14 does do VBZ cord-347946-i6kx3n6m 220 15 not not RB cord-347946-i6kx3n6m 220 16 easily easily RB cord-347946-i6kx3n6m 220 17 lend lend VB cord-347946-i6kx3n6m 220 18 itself -PRON- PRP cord-347946-i6kx3n6m 220 19 to to IN cord-347946-i6kx3n6m 220 20 social social JJ cord-347946-i6kx3n6m 220 21 explanations explanation NNS cord-347946-i6kx3n6m 220 22 for for IN cord-347946-i6kx3n6m 220 23 the the DT cord-347946-i6kx3n6m 220 24 high high JJ cord-347946-i6kx3n6m 220 25 prevalence prevalence NN cord-347946-i6kx3n6m 220 26 of of IN cord-347946-i6kx3n6m 220 27 either either DT cord-347946-i6kx3n6m 220 28 MDD MDD NNP cord-347946-i6kx3n6m 220 29 or or CC cord-347946-i6kx3n6m 220 30 putative putative JJ cord-347946-i6kx3n6m 220 31 depressogenic depressogenic JJ cord-347946-i6kx3n6m 220 32 risk risk NN cord-347946-i6kx3n6m 220 33 alleles allele NNS cord-347946-i6kx3n6m 220 34 . . . cord-347946-i6kx3n6m 221 1 On on IN cord-347946-i6kx3n6m 221 2 the the DT cord-347946-i6kx3n6m 221 3 other other JJ cord-347946-i6kx3n6m 221 4 hand hand NN cord-347946-i6kx3n6m 221 5 , , , cord-347946-i6kx3n6m 221 6 this this DT cord-347946-i6kx3n6m 221 7 association association NN cord-347946-i6kx3n6m 221 8 is be VBZ cord-347946-i6kx3n6m 221 9 foundational foundational JJ cord-347946-i6kx3n6m 221 10 to to IN cord-347946-i6kx3n6m 221 11 the the DT cord-347946-i6kx3n6m 221 12 proposal proposal NN cord-347946-i6kx3n6m 221 13 that that DT cord-347946-i6kx3n6m 221 14 depression depression NN cord-347946-i6kx3n6m 221 15 evolved evolve VBD cord-347946-i6kx3n6m 221 16 to to TO cord-347946-i6kx3n6m 221 17 serve serve VB cord-347946-i6kx3n6m 221 18 pathogen pathogen NN cord-347946-i6kx3n6m 221 19 - - HYPH cord-347946-i6kx3n6m 221 20 host host NN cord-347946-i6kx3n6m 221 21 defense defense NN cord-347946-i6kx3n6m 221 22 functions function NNS cord-347946-i6kx3n6m 221 23 . . . cord-347946-i6kx3n6m 222 1 However however RB cord-347946-i6kx3n6m 222 2 , , , cord-347946-i6kx3n6m 222 3 if if IN cord-347946-i6kx3n6m 222 4 this this DT cord-347946-i6kx3n6m 222 5 is be VBZ cord-347946-i6kx3n6m 222 6 indeed indeed RB cord-347946-i6kx3n6m 222 7 the the DT cord-347946-i6kx3n6m 222 8 case case NN cord-347946-i6kx3n6m 222 9 , , , cord-347946-i6kx3n6m 222 10 why why WRB cord-347946-i6kx3n6m 222 11 should should MD cord-347946-i6kx3n6m 222 12 we -PRON- PRP cord-347946-i6kx3n6m 222 13 expect expect VB cord-347946-i6kx3n6m 222 14 the the DT cord-347946-i6kx3n6m 222 15 immune immune JJ cord-347946-i6kx3n6m 222 16 changes change NNS cord-347946-i6kx3n6m 222 17 seen see VBN cord-347946-i6kx3n6m 222 18 in in IN cord-347946-i6kx3n6m 222 19 depression depression NN cord-347946-i6kx3n6m 222 20 to to TO cord-347946-i6kx3n6m 222 21 be be VB cord-347946-i6kx3n6m 222 22 limited limit VBN cord-347946-i6kx3n6m 222 23 to to IN cord-347946-i6kx3n6m 222 24 circulating circulate VBG cord-347946-i6kx3n6m 222 25 cytokines cytokine NNS cord-347946-i6kx3n6m 222 26 or or CC cord-347946-i6kx3n6m 222 27 CRP crp NN cord-347946-i6kx3n6m 222 28 ? ? . cord-347946-i6kx3n6m 223 1 In in IN cord-347946-i6kx3n6m 223 2 the the DT cord-347946-i6kx3n6m 223 3 context context NN cord-347946-i6kx3n6m 223 4 of of IN cord-347946-i6kx3n6m 223 5 innate innate JJ cord-347946-i6kx3n6m 223 6 immune immune JJ cord-347946-i6kx3n6m 223 7 activation activation NN cord-347946-i6kx3n6m 223 8 , , , cord-347946-i6kx3n6m 223 9 cytokine cytokine JJ cord-347946-i6kx3n6m 223 10 stimulation stimulation NN cord-347946-i6kx3n6m 223 11 forms form NNS cord-347946-i6kx3n6m 223 12 only only RB cord-347946-i6kx3n6m 223 13 part part NN cord-347946-i6kx3n6m 223 14 of of IN cord-347946-i6kx3n6m 223 15 a a DT cord-347946-i6kx3n6m 223 16 larger large JJR cord-347946-i6kx3n6m 223 17 phenomenon phenomenon NN cord-347946-i6kx3n6m 223 18 that that WDT cord-347946-i6kx3n6m 223 19 comprises comprise VBZ cord-347946-i6kx3n6m 223 20 the the DT cord-347946-i6kx3n6m 223 21 acute acute JJ cord-347946-i6kx3n6m 223 22 phase phase NN cord-347946-i6kx3n6m 223 23 response response NN cord-347946-i6kx3n6m 223 24 ( ( -LRB- cord-347946-i6kx3n6m 223 25 APR APR NNP cord-347946-i6kx3n6m 223 26 ) ) -RRB- cord-347946-i6kx3n6m 223 27 . . . cord-347946-i6kx3n6m 224 1 As as IN cord-347946-i6kx3n6m 224 2 noted note VBN cord-347946-i6kx3n6m 224 3 in in IN cord-347946-i6kx3n6m 224 4 a a DT cord-347946-i6kx3n6m 224 5 recent recent JJ cord-347946-i6kx3n6m 224 6 review review NN cord-347946-i6kx3n6m 224 7 ( ( -LRB- cord-347946-i6kx3n6m 224 8 LeGrand LeGrand NNP cord-347946-i6kx3n6m 224 9 and and CC cord-347946-i6kx3n6m 224 10 Alcock Alcock NNP cord-347946-i6kx3n6m 224 11 , , , cord-347946-i6kx3n6m 224 12 2012 2012 CD cord-347946-i6kx3n6m 224 13 ) ) -RRB- cord-347946-i6kx3n6m 224 14 , , , cord-347946-i6kx3n6m 224 15 the the DT cord-347946-i6kx3n6m 224 16 APR APR NNP cord-347946-i6kx3n6m 224 17 is be VBZ cord-347946-i6kx3n6m 224 18 a a DT cord-347946-i6kx3n6m 224 19 somewhat somewhat RB cord-347946-i6kx3n6m 224 20 paradoxical paradoxical JJ cord-347946-i6kx3n6m 224 21 phenomenon phenomenon NN cord-347946-i6kx3n6m 224 22 , , , cord-347946-i6kx3n6m 224 23 given give VBN cord-347946-i6kx3n6m 224 24 that that IN cord-347946-i6kx3n6m 224 25 many many JJ cord-347946-i6kx3n6m 224 26 of of IN cord-347946-i6kx3n6m 224 27 its -PRON- PRP$ cord-347946-i6kx3n6m 224 28 features feature NNS cord-347946-i6kx3n6m 224 29 inflict inflict VBP cord-347946-i6kx3n6m 224 30 significant significant JJ cord-347946-i6kx3n6m 224 31 energetic energetic JJ cord-347946-i6kx3n6m 224 32 costs cost NNS cord-347946-i6kx3n6m 224 33 ( ( -LRB- cord-347946-i6kx3n6m 224 34 eg eg IN cord-347946-i6kx3n6m 224 35 , , , cord-347946-i6kx3n6m 224 36 fever fever NN cord-347946-i6kx3n6m 224 37 ) ) -RRB- cord-347946-i6kx3n6m 224 38 , , , cord-347946-i6kx3n6m 224 39 hamstring hamstre VBG cord-347946-i6kx3n6m 224 40 immune immune JJ cord-347946-i6kx3n6m 224 41 responses response NNS cord-347946-i6kx3n6m 224 42 ( ( -LRB- cord-347946-i6kx3n6m 224 43 eg eg UH cord-347946-i6kx3n6m 224 44 , , , cord-347946-i6kx3n6m 224 45 iron iron NN cord-347946-i6kx3n6m 224 46 sequestration sequestration NN cord-347946-i6kx3n6m 224 47 , , , cord-347946-i6kx3n6m 224 48 zinc zinc NN cord-347946-i6kx3n6m 224 49 , , , cord-347946-i6kx3n6m 224 50 and and CC cord-347946-i6kx3n6m 224 51 tryptophan tryptophan NN cord-347946-i6kx3n6m 224 52 depletion depletion NN cord-347946-i6kx3n6m 224 53 ) ) -RRB- cord-347946-i6kx3n6m 224 54 , , , cord-347946-i6kx3n6m 224 55 or or CC cord-347946-i6kx3n6m 224 56 produce produce VB cord-347946-i6kx3n6m 224 57 behaviors behavior NNS cord-347946-i6kx3n6m 224 58 likely likely JJ cord-347946-i6kx3n6m 224 59 to to TO cord-347946-i6kx3n6m 224 60 reduce reduce VB cord-347946-i6kx3n6m 224 61 attractiveness attractiveness NN cord-347946-i6kx3n6m 224 62 to to IN cord-347946-i6kx3n6m 224 63 potential potential JJ cord-347946-i6kx3n6m 224 64 mates mate NNS cord-347946-i6kx3n6m 224 65 , , , cord-347946-i6kx3n6m 224 66 induce induce VB cord-347946-i6kx3n6m 224 67 loss loss NN cord-347946-i6kx3n6m 224 68 of of IN cord-347946-i6kx3n6m 224 69 social social JJ cord-347946-i6kx3n6m 224 70 status status NN cord-347946-i6kx3n6m 224 71 or or CC cord-347946-i6kx3n6m 224 72 increase increase VB cord-347946-i6kx3n6m 224 73 the the DT cord-347946-i6kx3n6m 224 74 risk risk NN cord-347946-i6kx3n6m 224 75 for for IN cord-347946-i6kx3n6m 224 76 predation predation NN cord-347946-i6kx3n6m 224 77 ( ( -LRB- cord-347946-i6kx3n6m 224 78 eg eg UH cord-347946-i6kx3n6m 224 79 , , , cord-347946-i6kx3n6m 224 80 lethargy lethargy NN cord-347946-i6kx3n6m 224 81 , , , cord-347946-i6kx3n6m 224 82 psychomotor psychomotor NN cord-347946-i6kx3n6m 224 83 slowing slow VBG cord-347946-i6kx3n6m 224 84 , , , cord-347946-i6kx3n6m 224 85 and and CC cord-347946-i6kx3n6m 224 86 social social JJ cord-347946-i6kx3n6m 224 87 withdrawal withdrawal NNP cord-347946-i6kx3n6m 224 88 ) ) -RRB- cord-347946-i6kx3n6m 224 89 , , , cord-347946-i6kx3n6m 224 90 all all DT cord-347946-i6kx3n6m 224 91 of of IN cord-347946-i6kx3n6m 224 92 which which WDT cord-347946-i6kx3n6m 224 93 would would MD cord-347946-i6kx3n6m 224 94 be be VB cord-347946-i6kx3n6m 224 95 expected expect VBN cord-347946-i6kx3n6m 224 96 to to TO cord-347946-i6kx3n6m 224 97 impair impair VB cord-347946-i6kx3n6m 224 98 , , , cord-347946-i6kx3n6m 224 99 rather rather RB cord-347946-i6kx3n6m 224 100 than than IN cord-347946-i6kx3n6m 224 101 enhance enhance VB cord-347946-i6kx3n6m 224 102 , , , cord-347946-i6kx3n6m 224 103 host host NN cord-347946-i6kx3n6m 224 104 survival survival NN cord-347946-i6kx3n6m 224 105 , , , cord-347946-i6kx3n6m 224 106 and and CC cord-347946-i6kx3n6m 224 107 reproduction reproduction NN cord-347946-i6kx3n6m 224 108 . . . cord-347946-i6kx3n6m 225 1 And and CC cord-347946-i6kx3n6m 225 2 while while IN cord-347946-i6kx3n6m 225 3 fever fever NN cord-347946-i6kx3n6m 225 4 has have VBZ cord-347946-i6kx3n6m 225 5 been be VBN cord-347946-i6kx3n6m 225 6 shown show VBN cord-347946-i6kx3n6m 225 7 to to TO cord-347946-i6kx3n6m 225 8 enhance enhance VB cord-347946-i6kx3n6m 225 9 immune immune JJ cord-347946-i6kx3n6m 225 10 function function NN cord-347946-i6kx3n6m 225 11 while while IN cord-347946-i6kx3n6m 225 12 simultaneously simultaneously RB cord-347946-i6kx3n6m 225 13 contributing contribute VBG cord-347946-i6kx3n6m 225 14 directly directly RB cord-347946-i6kx3n6m 225 15 to to IN cord-347946-i6kx3n6m 225 16 pathogen pathogen NN cord-347946-i6kx3n6m 225 17 killing killing NN cord-347946-i6kx3n6m 225 18 , , , cord-347946-i6kx3n6m 225 19 no no DT cord-347946-i6kx3n6m 225 20 direct direct JJ cord-347946-i6kx3n6m 225 21 immune immune JJ cord-347946-i6kx3n6m 225 22 benefits benefit NNS cord-347946-i6kx3n6m 225 23 have have VBP cord-347946-i6kx3n6m 225 24 been be VBN cord-347946-i6kx3n6m 225 25 shown show VBN cord-347946-i6kx3n6m 225 26 for for IN cord-347946-i6kx3n6m 225 27 many many JJ cord-347946-i6kx3n6m 225 28 other other JJ cord-347946-i6kx3n6m 225 29 APR APR NNP cord-347946-i6kx3n6m 225 30 features feature NNS cord-347946-i6kx3n6m 225 31 . . . cord-347946-i6kx3n6m 226 1 A a DT cord-347946-i6kx3n6m 226 2 potential potential JJ cord-347946-i6kx3n6m 226 3 resolution resolution NN cord-347946-i6kx3n6m 226 4 to to IN cord-347946-i6kx3n6m 226 5 this this DT cord-347946-i6kx3n6m 226 6 enigma enigma NN cord-347946-i6kx3n6m 226 7 has have VBZ cord-347946-i6kx3n6m 226 8 been be VBN cord-347946-i6kx3n6m 226 9 offered offer VBN cord-347946-i6kx3n6m 226 10 recently recently RB cord-347946-i6kx3n6m 226 11 under under IN cord-347946-i6kx3n6m 226 12 the the DT cord-347946-i6kx3n6m 226 13 rubric rubric NN cord-347946-i6kx3n6m 226 14 of of IN cord-347946-i6kx3n6m 226 15 ' ' `` cord-347946-i6kx3n6m 226 16 immune immune JJ cord-347946-i6kx3n6m 226 17 brinksmanship brinksmanship NN cord-347946-i6kx3n6m 226 18 ' ' '' cord-347946-i6kx3n6m 226 19 , , , cord-347946-i6kx3n6m 226 20 which which WDT cord-347946-i6kx3n6m 226 21 suggests suggest VBZ cord-347946-i6kx3n6m 226 22 that that IN cord-347946-i6kx3n6m 226 23 many many JJ cord-347946-i6kx3n6m 226 24 APR APR NNP cord-347946-i6kx3n6m 226 25 features feature NNS cord-347946-i6kx3n6m 226 26 - - , cord-347946-i6kx3n6m 226 27 such such JJ cord-347946-i6kx3n6m 226 28 as as IN cord-347946-i6kx3n6m 226 29 iron iron NN cord-347946-i6kx3n6m 226 30 sequestration sequestration NN cord-347946-i6kx3n6m 226 31 and and CC cord-347946-i6kx3n6m 226 32 reduced reduced JJ cord-347946-i6kx3n6m 226 33 zinc zinc NN cord-347946-i6kx3n6m 226 34 availability availability NN cord-347946-i6kx3n6m 226 35 - - : cord-347946-i6kx3n6m 226 36 have have VBP cord-347946-i6kx3n6m 226 37 evolved evolve VBN cord-347946-i6kx3n6m 226 38 to to TO cord-347946-i6kx3n6m 226 39 make make VB cord-347946-i6kx3n6m 226 40 the the DT cord-347946-i6kx3n6m 226 41 host host NN cord-347946-i6kx3n6m 226 42 environment environment NN cord-347946-i6kx3n6m 226 43 less less RBR cord-347946-i6kx3n6m 226 44 optimal optimal JJ cord-347946-i6kx3n6m 226 45 for for IN cord-347946-i6kx3n6m 226 46 invading invade VBG cord-347946-i6kx3n6m 226 47 organisms organism NNS cord-347946-i6kx3n6m 226 48 , , , cord-347946-i6kx3n6m 226 49 given give VBN cord-347946-i6kx3n6m 226 50 that that IN cord-347946-i6kx3n6m 226 51 these these DT cord-347946-i6kx3n6m 226 52 minerals mineral NNS cord-347946-i6kx3n6m 226 53 are be VBP cord-347946-i6kx3n6m 226 54 essential essential JJ cord-347946-i6kx3n6m 226 55 nutrients nutrient NNS cord-347946-i6kx3n6m 226 56 for for IN cord-347946-i6kx3n6m 226 57 microorganisms microorganism NNS cord-347946-i6kx3n6m 226 58 , , , cord-347946-i6kx3n6m 226 59 without without IN cord-347946-i6kx3n6m 226 60 which which WDT cord-347946-i6kx3n6m 226 61 they -PRON- PRP cord-347946-i6kx3n6m 226 62 can can MD cord-347946-i6kx3n6m 226 63 neither neither CC cord-347946-i6kx3n6m 226 64 replicate replicate VB cord-347946-i6kx3n6m 226 65 nor nor CC cord-347946-i6kx3n6m 226 66 survive survive VB cord-347946-i6kx3n6m 226 67 ( ( -LRB- cord-347946-i6kx3n6m 227 1 LeGrand LeGrand NNP cord-347946-i6kx3n6m 227 2 and and CC cord-347946-i6kx3n6m 227 3 Alcock Alcock NNP cord-347946-i6kx3n6m 227 4 , , , cord-347946-i6kx3n6m 227 5 2012 2012 CD cord-347946-i6kx3n6m 227 6 ) ) -RRB- cord-347946-i6kx3n6m 227 7 . . . cord-347946-i6kx3n6m 228 1 From from IN cord-347946-i6kx3n6m 228 2 this this DT cord-347946-i6kx3n6m 228 3 perspective perspective NN cord-347946-i6kx3n6m 228 4 the the DT cord-347946-i6kx3n6m 228 5 APR APR NNP cord-347946-i6kx3n6m 228 6 can can MD cord-347946-i6kx3n6m 228 7 be be VB cord-347946-i6kx3n6m 228 8 seen see VBN cord-347946-i6kx3n6m 228 9 as as IN cord-347946-i6kx3n6m 228 10 being be VBG cord-347946-i6kx3n6m 228 11 , , , cord-347946-i6kx3n6m 228 12 in in IN cord-347946-i6kx3n6m 228 13 part part NN cord-347946-i6kx3n6m 228 14 , , , cord-347946-i6kx3n6m 228 15 a a DT cord-347946-i6kx3n6m 228 16 strategy strategy NN cord-347946-i6kx3n6m 228 17 that that WDT cord-347946-i6kx3n6m 228 18 risks risk VBZ cord-347946-i6kx3n6m 228 19 damage damage NN cord-347946-i6kx3n6m 228 20 to to IN cord-347946-i6kx3n6m 228 21 the the DT cord-347946-i6kx3n6m 228 22 self self NN cord-347946-i6kx3n6m 228 23 , , , cord-347946-i6kx3n6m 228 24 but but CC cord-347946-i6kx3n6m 228 25 that that DT cord-347946-i6kx3n6m 228 26 is be VBZ cord-347946-i6kx3n6m 228 27 likely likely JJ cord-347946-i6kx3n6m 228 28 to to TO cord-347946-i6kx3n6m 228 29 kill kill VB cord-347946-i6kx3n6m 228 30 the the DT cord-347946-i6kx3n6m 228 31 offending offend VBG cord-347946-i6kx3n6m 228 32 agent agent NN cord-347946-i6kx3n6m 228 33 before before IN cord-347946-i6kx3n6m 228 34 it -PRON- PRP cord-347946-i6kx3n6m 228 35 kills kill VBZ cord-347946-i6kx3n6m 228 36 the the DT cord-347946-i6kx3n6m 228 37 host host NN cord-347946-i6kx3n6m 228 38 . . . cord-347946-i6kx3n6m 229 1 A a DT cord-347946-i6kx3n6m 229 2 comprehensive comprehensive JJ cord-347946-i6kx3n6m 229 3 vision vision NN cord-347946-i6kx3n6m 229 4 of of IN cord-347946-i6kx3n6m 229 5 the the DT cord-347946-i6kx3n6m 229 6 APR APR NNP cord-347946-i6kx3n6m 229 7 sees see VBZ cord-347946-i6kx3n6m 229 8 some some DT cord-347946-i6kx3n6m 229 9 of of IN cord-347946-i6kx3n6m 229 10 its -PRON- PRP$ cord-347946-i6kx3n6m 229 11 elements element NNS cord-347946-i6kx3n6m 229 12 as as IN cord-347946-i6kx3n6m 229 13 serving serve VBG cord-347946-i6kx3n6m 229 14 direct direct JJ cord-347946-i6kx3n6m 229 15 anti anti JJ cord-347946-i6kx3n6m 229 16 - - JJ cord-347946-i6kx3n6m 229 17 pathogen pathogen JJ cord-347946-i6kx3n6m 229 18 functions function NNS cord-347946-i6kx3n6m 229 19 ( ( -LRB- cord-347946-i6kx3n6m 229 20 eg eg UH cord-347946-i6kx3n6m 229 21 , , , cord-347946-i6kx3n6m 229 22 leukocytosis leukocytosis NNP cord-347946-i6kx3n6m 229 23 ) ) -RRB- cord-347946-i6kx3n6m 229 24 , , , cord-347946-i6kx3n6m 229 25 some some DT cord-347946-i6kx3n6m 229 26 as as IN cord-347946-i6kx3n6m 229 27 serving serve VBG cord-347946-i6kx3n6m 229 28 to to TO cord-347946-i6kx3n6m 229 29 reallocate reallocate VB cord-347946-i6kx3n6m 229 30 energy energy NN cord-347946-i6kx3n6m 229 31 to to IN cord-347946-i6kx3n6m 229 32 the the DT cord-347946-i6kx3n6m 229 33 immune immune JJ cord-347946-i6kx3n6m 229 34 system system NN cord-347946-i6kx3n6m 229 35 ( ( -LRB- cord-347946-i6kx3n6m 229 36 eg eg IN cord-347946-i6kx3n6m 229 37 , , , cord-347946-i6kx3n6m 229 38 psychomotor psychomotor JJ cord-347946-i6kx3n6m 229 39 slowing slowing NN cord-347946-i6kx3n6m 229 40 , , , cord-347946-i6kx3n6m 229 41 somnolence somnolence NN cord-347946-i6kx3n6m 229 42 ) ) -RRB- cord-347946-i6kx3n6m 229 43 and and CC cord-347946-i6kx3n6m 229 44 some some DT cord-347946-i6kx3n6m 229 45 as as IN cord-347946-i6kx3n6m 229 46 serving serve VBG cord-347946-i6kx3n6m 229 47 ' ' `` cord-347946-i6kx3n6m 229 48 immune immune JJ cord-347946-i6kx3n6m 229 49 brinkmanship brinkmanship NN cord-347946-i6kx3n6m 229 50 ' ' '' cord-347946-i6kx3n6m 229 51 functions function NNS cord-347946-i6kx3n6m 229 52 . . . cord-347946-i6kx3n6m 230 1 Studies study NNS cord-347946-i6kx3n6m 230 2 suggest suggest VBP cord-347946-i6kx3n6m 230 3 that that IN cord-347946-i6kx3n6m 230 4 , , , cord-347946-i6kx3n6m 230 5 as as IN cord-347946-i6kx3n6m 230 6 a a DT cord-347946-i6kx3n6m 230 7 group group NN cord-347946-i6kx3n6m 230 8 , , , cord-347946-i6kx3n6m 230 9 medically medically RB cord-347946-i6kx3n6m 230 10 healthy healthy JJ cord-347946-i6kx3n6m 230 11 individuals individual NNS cord-347946-i6kx3n6m 230 12 with with IN cord-347946-i6kx3n6m 230 13 depression depression NN cord-347946-i6kx3n6m 230 14 demonstrate demonstrate VBP cord-347946-i6kx3n6m 230 15 multiple multiple JJ cord-347946-i6kx3n6m 230 16 biological biological JJ cord-347946-i6kx3n6m 230 17 and and CC cord-347946-i6kx3n6m 230 18 behavioral behavioral JJ cord-347946-i6kx3n6m 230 19 stigmata stigmata NN cord-347946-i6kx3n6m 230 20 of of IN cord-347946-i6kx3n6m 230 21 an an DT cord-347946-i6kx3n6m 230 22 APR APR NNP cord-347946-i6kx3n6m 230 23 ( ( -LRB- cord-347946-i6kx3n6m 230 24 Jimenez Jimenez NNP cord-347946-i6kx3n6m 230 25 - - HYPH cord-347946-i6kx3n6m 230 26 Fernandez Fernandez NNP cord-347946-i6kx3n6m 230 27 et et NNP cord-347946-i6kx3n6m 230 28 al al NNP cord-347946-i6kx3n6m 230 29 , , , cord-347946-i6kx3n6m 230 30 2015 2015 CD cord-347946-i6kx3n6m 230 31 ) ) -RRB- cord-347946-i6kx3n6m 230 32 . . . cord-347946-i6kx3n6m 231 1 For for IN cord-347946-i6kx3n6m 231 2 a a DT cord-347946-i6kx3n6m 231 3 full full JJ cord-347946-i6kx3n6m 231 4 listing listing NN cord-347946-i6kx3n6m 231 5 of of IN cord-347946-i6kx3n6m 231 6 elements element NNS cord-347946-i6kx3n6m 231 7 of of IN cord-347946-i6kx3n6m 231 8 the the DT cord-347946-i6kx3n6m 231 9 APR APR NNP cord-347946-i6kx3n6m 231 10 that that WDT cord-347946-i6kx3n6m 231 11 have have VBP cord-347946-i6kx3n6m 231 12 been be VBN cord-347946-i6kx3n6m 231 13 associated associate VBN cord-347946-i6kx3n6m 231 14 with with IN cord-347946-i6kx3n6m 231 15 MDD MDD NNP cord-347946-i6kx3n6m 231 16 in in IN cord-347946-i6kx3n6m 231 17 medically medically RB cord-347946-i6kx3n6m 231 18 healthy healthy JJ cord-347946-i6kx3n6m 231 19 individuals individual NNS cord-347946-i6kx3n6m 231 20 , , , cord-347946-i6kx3n6m 231 21 see see VB cord-347946-i6kx3n6m 231 22 Supplementary supplementary JJ cord-347946-i6kx3n6m 231 23 Table Table NNP cord-347946-i6kx3n6m 231 24 S2 s2 NN cord-347946-i6kx3n6m 231 25 . . . cord-347946-i6kx3n6m 232 1 Importantly importantly RB cord-347946-i6kx3n6m 232 2 , , , cord-347946-i6kx3n6m 232 3 at at RB cord-347946-i6kx3n6m 232 4 least least RBS cord-347946-i6kx3n6m 232 5 one one CD cord-347946-i6kx3n6m 232 6 group group NN cord-347946-i6kx3n6m 232 7 has have VBZ cord-347946-i6kx3n6m 232 8 found find VBN cord-347946-i6kx3n6m 232 9 that that IN cord-347946-i6kx3n6m 232 10 the the DT cord-347946-i6kx3n6m 232 11 APR APR NNP cord-347946-i6kx3n6m 232 12 in in IN cord-347946-i6kx3n6m 232 13 medically medically RB cord-347946-i6kx3n6m 232 14 healthy healthy JJ cord-347946-i6kx3n6m 232 15 adults adult NNS cord-347946-i6kx3n6m 232 16 with with IN cord-347946-i6kx3n6m 232 17 MDD MDD NNP cord-347946-i6kx3n6m 232 18 is be VBZ cord-347946-i6kx3n6m 232 19 associated associate VBN cord-347946-i6kx3n6m 232 20 with with IN cord-347946-i6kx3n6m 232 21 increased increase VBN cord-347946-i6kx3n6m 232 22 levels level NNS cord-347946-i6kx3n6m 232 23 of of IN cord-347946-i6kx3n6m 232 24 IL-6 IL-6 NNP cord-347946-i6kx3n6m 232 25 , , , cord-347946-i6kx3n6m 232 26 suggesting suggest VBG cord-347946-i6kx3n6m 232 27 that that IN cord-347946-i6kx3n6m 232 28 the the DT cord-347946-i6kx3n6m 232 29 APR APR NNP cord-347946-i6kx3n6m 232 30 is be VBZ cord-347946-i6kx3n6m 232 31 indeed indeed RB cord-347946-i6kx3n6m 232 32 part part NN cord-347946-i6kx3n6m 232 33 of of IN cord-347946-i6kx3n6m 232 34 a a DT cord-347946-i6kx3n6m 232 35 larger large JJR cord-347946-i6kx3n6m 232 36 pathogen pathogen NN cord-347946-i6kx3n6m 232 37 - - HYPH cord-347946-i6kx3n6m 232 38 host host NN cord-347946-i6kx3n6m 232 39 defense defense NN cord-347946-i6kx3n6m 232 40 immune immune JJ cord-347946-i6kx3n6m 232 41 response response NN cord-347946-i6kx3n6m 232 42 ( ( -LRB- cord-347946-i6kx3n6m 232 43 Maes Maes NNP cord-347946-i6kx3n6m 232 44 et et NNP cord-347946-i6kx3n6m 232 45 al al NNP cord-347946-i6kx3n6m 232 46 , , , cord-347946-i6kx3n6m 232 47 1995 1995 CD cord-347946-i6kx3n6m 232 48 ; ; : cord-347946-i6kx3n6m 232 49 Sluzewska Sluzewska NNP cord-347946-i6kx3n6m 232 50 et et FW cord-347946-i6kx3n6m 232 51 al al NNP cord-347946-i6kx3n6m 232 52 , , , cord-347946-i6kx3n6m 232 53 1996 1996 CD cord-347946-i6kx3n6m 232 54 ) ) -RRB- cord-347946-i6kx3n6m 232 55 . . . cord-347946-i6kx3n6m 233 1 Moreover moreover RB cord-347946-i6kx3n6m 233 2 , , , cord-347946-i6kx3n6m 233 3 if if IN cord-347946-i6kx3n6m 233 4 psychosocial psychosocial JJ cord-347946-i6kx3n6m 233 5 stress stress NN cord-347946-i6kx3n6m 233 6 serves serve VBZ cord-347946-i6kx3n6m 233 7 as as IN cord-347946-i6kx3n6m 233 8 an an DT cord-347946-i6kx3n6m 233 9 ' ' `` cord-347946-i6kx3n6m 233 10 early early JJ cord-347946-i6kx3n6m 233 11 warning warning NN cord-347946-i6kx3n6m 233 12 system system NN cord-347946-i6kx3n6m 233 13 ' ' '' cord-347946-i6kx3n6m 233 14 for for IN cord-347946-i6kx3n6m 233 15 increased increase VBN cord-347946-i6kx3n6m 233 16 danger danger NN cord-347946-i6kx3n6m 233 17 of of IN cord-347946-i6kx3n6m 233 18 impending impending JJ cord-347946-i6kx3n6m 233 19 wounding wounding NN cord-347946-i6kx3n6m 233 20 and and CC cord-347946-i6kx3n6m 233 21 subsequent subsequent JJ cord-347946-i6kx3n6m 233 22 infection infection NN cord-347946-i6kx3n6m 233 23 , , , cord-347946-i6kx3n6m 233 24 PATHOS pathos NN cord-347946-i6kx3n6m 233 25 - - HYPH cord-347946-i6kx3n6m 233 26 D D NNP cord-347946-i6kx3n6m 233 27 would would MD cord-347946-i6kx3n6m 233 28 predict predict VB cord-347946-i6kx3n6m 233 29 that that IN cord-347946-i6kx3n6m 233 30 psychosocial psychosocial JJ cord-347946-i6kx3n6m 233 31 adversity adversity NN cord-347946-i6kx3n6m 233 32 should should MD cord-347946-i6kx3n6m 233 33 also also RB cord-347946-i6kx3n6m 233 34 be be VB cord-347946-i6kx3n6m 233 35 associated associate VBN cord-347946-i6kx3n6m 233 36 with with IN cord-347946-i6kx3n6m 233 37 an an DT cord-347946-i6kx3n6m 233 38 APR APR NNP cord-347946-i6kx3n6m 233 39 over over IN cord-347946-i6kx3n6m 233 40 and and CC cord-347946-i6kx3n6m 233 41 above above IN cord-347946-i6kx3n6m 233 42 activation activation NN cord-347946-i6kx3n6m 233 43 of of IN cord-347946-i6kx3n6m 233 44 cytokines cytokine NNS cord-347946-i6kx3n6m 233 45 . . . cord-347946-i6kx3n6m 234 1 Consistent consistent JJ cord-347946-i6kx3n6m 234 2 with with IN cord-347946-i6kx3n6m 234 3 this this DT cord-347946-i6kx3n6m 234 4 possibility possibility NN cord-347946-i6kx3n6m 234 5 , , , cord-347946-i6kx3n6m 234 6 stress stress NN cord-347946-i6kx3n6m 234 7 in in IN cord-347946-i6kx3n6m 234 8 animals animal NNS cord-347946-i6kx3n6m 234 9 reduces reduce VBZ cord-347946-i6kx3n6m 234 10 gastrointestinal gastrointestinal JJ cord-347946-i6kx3n6m 234 11 absorption absorption NN cord-347946-i6kx3n6m 234 12 and and CC cord-347946-i6kx3n6m 234 13 blood blood NN cord-347946-i6kx3n6m 234 14 levels level NNS cord-347946-i6kx3n6m 234 15 of of IN cord-347946-i6kx3n6m 234 16 iron iron NN cord-347946-i6kx3n6m 234 17 ( ( -LRB- cord-347946-i6kx3n6m 234 18 Zhao Zhao NNP cord-347946-i6kx3n6m 234 19 et et NNP cord-347946-i6kx3n6m 234 20 al al NNP cord-347946-i6kx3n6m 234 21 , , , cord-347946-i6kx3n6m 234 22 2008 2008 CD cord-347946-i6kx3n6m 234 23 ; ; : cord-347946-i6kx3n6m 235 1 Chen Chen NNP cord-347946-i6kx3n6m 235 2 et et NNP cord-347946-i6kx3n6m 235 3 al al NNP cord-347946-i6kx3n6m 235 4 , , , cord-347946-i6kx3n6m 235 5 2009 2009 CD cord-347946-i6kx3n6m 235 6 ) ) -RRB- cord-347946-i6kx3n6m 235 7 and and CC cord-347946-i6kx3n6m 235 8 in in IN cord-347946-i6kx3n6m 235 9 human human JJ cord-347946-i6kx3n6m 235 10 males male NNS cord-347946-i6kx3n6m 235 11 a a DT cord-347946-i6kx3n6m 235 12 5-day 5-day JJ cord-347946-i6kx3n6m 235 13 intense intense JJ cord-347946-i6kx3n6m 235 14 psychological psychological JJ cord-347946-i6kx3n6m 235 15 stressor stressor NN cord-347946-i6kx3n6m 235 16 ( ( -LRB- cord-347946-i6kx3n6m 235 17 ' ' `` cord-347946-i6kx3n6m 235 18 Hell Hell NNP cord-347946-i6kx3n6m 235 19 Week Week NNP cord-347946-i6kx3n6m 235 20 ' ' '' cord-347946-i6kx3n6m 235 21 ) ) -RRB- cord-347946-i6kx3n6m 235 22 reduced reduce VBN cord-347946-i6kx3n6m 235 23 blood blood NN cord-347946-i6kx3n6m 235 24 levels level NNS cord-347946-i6kx3n6m 235 25 of of IN cord-347946-i6kx3n6m 235 26 iron iron NN cord-347946-i6kx3n6m 235 27 , , , cord-347946-i6kx3n6m 235 28 zinc zinc NN cord-347946-i6kx3n6m 235 29 , , , cord-347946-i6kx3n6m 235 30 and and CC cord-347946-i6kx3n6m 235 31 albumin albumin NN cord-347946-i6kx3n6m 235 32 ( ( -LRB- cord-347946-i6kx3n6m 235 33 Singh Singh NNP cord-347946-i6kx3n6m 235 34 et et NNP cord-347946-i6kx3n6m 235 35 al al NNP cord-347946-i6kx3n6m 235 36 , , , cord-347946-i6kx3n6m 235 37 1991 1991 CD cord-347946-i6kx3n6m 235 38 ) ) -RRB- cord-347946-i6kx3n6m 235 39 , , , cord-347946-i6kx3n6m 235 40 as as IN cord-347946-i6kx3n6m 235 41 would would MD cord-347946-i6kx3n6m 235 42 be be VB cord-347946-i6kx3n6m 235 43 predicted predict VBN cord-347946-i6kx3n6m 235 44 if if IN cord-347946-i6kx3n6m 235 45 stress stress NN cord-347946-i6kx3n6m 235 46 induces induce VBZ cord-347946-i6kx3n6m 235 47 an an DT cord-347946-i6kx3n6m 235 48 APR APR NNP cord-347946-i6kx3n6m 235 49 . . . cord-347946-i6kx3n6m 236 1 Psychological psychological JJ cord-347946-i6kx3n6m 236 2 stress stress NN cord-347946-i6kx3n6m 236 3 has have VBZ cord-347946-i6kx3n6m 236 4 also also RB cord-347946-i6kx3n6m 236 5 been be VBN cord-347946-i6kx3n6m 236 6 reported report VBN cord-347946-i6kx3n6m 236 7 to to TO cord-347946-i6kx3n6m 236 8 elevate elevate VB cord-347946-i6kx3n6m 236 9 core core NN cord-347946-i6kx3n6m 236 10 body body NN cord-347946-i6kx3n6m 236 11 temperature temperature NN cord-347946-i6kx3n6m 236 12 in in IN cord-347946-i6kx3n6m 236 13 animals animal NNS cord-347946-i6kx3n6m 236 14 and and CC cord-347946-i6kx3n6m 236 15 humans human NNS cord-347946-i6kx3n6m 236 16 ( ( -LRB- cord-347946-i6kx3n6m 236 17 Soszynski Soszynski NNP cord-347946-i6kx3n6m 236 18 et et FW cord-347946-i6kx3n6m 236 19 al al NNP cord-347946-i6kx3n6m 236 20 , , , cord-347946-i6kx3n6m 236 21 1996 1996 CD cord-347946-i6kx3n6m 236 22 ; ; : cord-347946-i6kx3n6m 236 23 Kaneda Kaneda NNP cord-347946-i6kx3n6m 236 24 et et NNP cord-347946-i6kx3n6m 236 25 al al NNP cord-347946-i6kx3n6m 236 26 , , , cord-347946-i6kx3n6m 236 27 2009 2009 CD cord-347946-i6kx3n6m 236 28 ; ; : cord-347946-i6kx3n6m 236 29 Hayashida Hayashida NNP cord-347946-i6kx3n6m 236 30 et et NNP cord-347946-i6kx3n6m 236 31 al al NNP cord-347946-i6kx3n6m 236 32 , , , cord-347946-i6kx3n6m 236 33 2010 2010 CD cord-347946-i6kx3n6m 236 34 ) ) -RRB- cord-347946-i6kx3n6m 236 35 , , , cord-347946-i6kx3n6m 236 36 an an DT cord-347946-i6kx3n6m 236 37 anti anti JJ cord-347946-i6kx3n6m 236 38 - - JJ cord-347946-i6kx3n6m 236 39 pathogen pathogen JJ cord-347946-i6kx3n6m 236 40 defense defense NN cord-347946-i6kx3n6m 236 41 mechanism mechanism NN cord-347946-i6kx3n6m 236 42 that that WDT cord-347946-i6kx3n6m 236 43 is be VBZ cord-347946-i6kx3n6m 236 44 most most RBS cord-347946-i6kx3n6m 236 45 effective effective JJ cord-347946-i6kx3n6m 236 46 in in IN cord-347946-i6kx3n6m 236 47 conditions condition NNS cord-347946-i6kx3n6m 236 48 of of IN cord-347946-i6kx3n6m 236 49 low low JJ cord-347946-i6kx3n6m 236 50 host host NN cord-347946-i6kx3n6m 236 51 iron iron NN cord-347946-i6kx3n6m 236 52 availability availability NN cord-347946-i6kx3n6m 236 53 ( ( -LRB- cord-347946-i6kx3n6m 236 54 Kluger Kluger NNP cord-347946-i6kx3n6m 236 55 and and CC cord-347946-i6kx3n6m 236 56 Rothenburg Rothenburg NNP cord-347946-i6kx3n6m 236 57 , , , cord-347946-i6kx3n6m 236 58 1979 1979 CD cord-347946-i6kx3n6m 236 59 ) ) -RRB- cord-347946-i6kx3n6m 236 60 . . . cord-347946-i6kx3n6m 237 1 That that IN cord-347946-i6kx3n6m 237 2 these these DT cord-347946-i6kx3n6m 237 3 changes change NNS cord-347946-i6kx3n6m 237 4 serve serve VBP cord-347946-i6kx3n6m 237 5 immune immune JJ cord-347946-i6kx3n6m 237 6 purposes purpose NNS cord-347946-i6kx3n6m 237 7 is be VBZ cord-347946-i6kx3n6m 237 8 suggested suggest VBN cord-347946-i6kx3n6m 237 9 by by IN cord-347946-i6kx3n6m 237 10 findings finding NNS cord-347946-i6kx3n6m 237 11 that that IN cord-347946-i6kx3n6m 237 12 in in IN cord-347946-i6kx3n6m 237 13 animals animal NNS cord-347946-i6kx3n6m 237 14 , , , cord-347946-i6kx3n6m 237 15 stressinduced stressinduced NNP cord-347946-i6kx3n6m 237 16 hypoferremia hypoferremia NNP cord-347946-i6kx3n6m 237 17 and and CC cord-347946-i6kx3n6m 237 18 hyperthermia hyperthermia NN cord-347946-i6kx3n6m 237 19 are be VBP cord-347946-i6kx3n6m 237 20 associated associate VBN cord-347946-i6kx3n6m 237 21 with with IN cord-347946-i6kx3n6m 237 22 stress stress NN cord-347946-i6kx3n6m 237 23 - - HYPH cord-347946-i6kx3n6m 237 24 induced induce VBN cord-347946-i6kx3n6m 237 25 increases increase NNS cord-347946-i6kx3n6m 237 26 in in IN cord-347946-i6kx3n6m 237 27 IL-6 IL-6 NNP cord-347946-i6kx3n6m 237 28 ( ( -LRB- cord-347946-i6kx3n6m 237 29 Soszynski Soszynski NNP cord-347946-i6kx3n6m 237 30 et et FW cord-347946-i6kx3n6m 237 31 al al NNP cord-347946-i6kx3n6m 237 32 , , , cord-347946-i6kx3n6m 237 33 1996 1996 CD cord-347946-i6kx3n6m 237 34 ; ; : cord-347946-i6kx3n6m 237 35 Zhao Zhao NNP cord-347946-i6kx3n6m 237 36 et et NNP cord-347946-i6kx3n6m 237 37 al al NNP cord-347946-i6kx3n6m 237 38 , , , cord-347946-i6kx3n6m 237 39 2008 2008 CD cord-347946-i6kx3n6m 237 40 ) ) -RRB- cord-347946-i6kx3n6m 237 41 ; ; : cord-347946-i6kx3n6m 237 42 however however RB cord-347946-i6kx3n6m 237 43 , , , cord-347946-i6kx3n6m 237 44 other other JJ cord-347946-i6kx3n6m 237 45 mechanisms mechanism NNS cord-347946-i6kx3n6m 237 46 may may MD cord-347946-i6kx3n6m 237 47 also also RB cord-347946-i6kx3n6m 237 48 be be VB cord-347946-i6kx3n6m 237 49 active active JJ cord-347946-i6kx3n6m 237 50 , , , cord-347946-i6kx3n6m 237 51 including include VBG cord-347946-i6kx3n6m 237 52 hypothalamic hypothalamic JJ cord-347946-i6kx3n6m 237 53 activation activation NN cord-347946-i6kx3n6m 237 54 of of IN cord-347946-i6kx3n6m 237 55 brown brown JJ cord-347946-i6kx3n6m 237 56 fat fat NN cord-347946-i6kx3n6m 237 57 ( ( -LRB- cord-347946-i6kx3n6m 237 58 Kataoka Kataoka NNP cord-347946-i6kx3n6m 237 59 et et NNP cord-347946-i6kx3n6m 237 60 al al NNP cord-347946-i6kx3n6m 237 61 , , , cord-347946-i6kx3n6m 237 62 2014 2014 CD cord-347946-i6kx3n6m 237 63 ) ) -RRB- cord-347946-i6kx3n6m 237 64 . . . cord-347946-i6kx3n6m 238 1 Because because IN cord-347946-i6kx3n6m 238 2 at at IN cord-347946-i6kx3n6m 238 3 least least JJS cord-347946-i6kx3n6m 238 4 some some DT cord-347946-i6kx3n6m 238 5 biological biological JJ cord-347946-i6kx3n6m 238 6 changes change NNS cord-347946-i6kx3n6m 238 7 associated associate VBN cord-347946-i6kx3n6m 238 8 with with IN cord-347946-i6kx3n6m 238 9 the the DT cord-347946-i6kx3n6m 238 10 APR APR NNP cord-347946-i6kx3n6m 238 11 have have VBP cord-347946-i6kx3n6m 238 12 been be VBN cord-347946-i6kx3n6m 238 13 shown show VBN cord-347946-i6kx3n6m 238 14 to to TO cord-347946-i6kx3n6m 238 15 have have VB cord-347946-i6kx3n6m 238 16 important important JJ cord-347946-i6kx3n6m 238 17 roles role NNS cord-347946-i6kx3n6m 238 18 in in IN cord-347946-i6kx3n6m 238 19 pathogen pathogen NN cord-347946-i6kx3n6m 238 20 - - HYPH cord-347946-i6kx3n6m 238 21 host host NN cord-347946-i6kx3n6m 238 22 defense defense NN cord-347946-i6kx3n6m 238 23 , , , cord-347946-i6kx3n6m 238 24 their -PRON- PRP$ cord-347946-i6kx3n6m 238 25 presence presence NN cord-347946-i6kx3n6m 238 26 in in IN cord-347946-i6kx3n6m 238 27 depression depression NN cord-347946-i6kx3n6m 238 28 would would MD cord-347946-i6kx3n6m 238 29 be be VB cord-347946-i6kx3n6m 238 30 strongly strongly RB cord-347946-i6kx3n6m 238 31 predicted predict VBN cord-347946-i6kx3n6m 238 32 by by IN cord-347946-i6kx3n6m 238 33 PATHOS PATHOS NNP cord-347946-i6kx3n6m 238 34 - - HYPH cord-347946-i6kx3n6m 238 35 D D NNP cord-347946-i6kx3n6m 238 36 , , , cord-347946-i6kx3n6m 238 37 and and CC cord-347946-i6kx3n6m 238 38 their -PRON- PRP$ cord-347946-i6kx3n6m 238 39 absence absence NN cord-347946-i6kx3n6m 238 40 would would MD cord-347946-i6kx3n6m 238 41 strongly strongly RB cord-347946-i6kx3n6m 238 42 argue argue VB cord-347946-i6kx3n6m 238 43 against against IN cord-347946-i6kx3n6m 238 44 the the DT cord-347946-i6kx3n6m 238 45 validity validity NN cord-347946-i6kx3n6m 238 46 of of IN cord-347946-i6kx3n6m 238 47 this this DT cord-347946-i6kx3n6m 238 48 approach approach NN cord-347946-i6kx3n6m 238 49 . . . cord-347946-i6kx3n6m 239 1 On on IN cord-347946-i6kx3n6m 239 2 the the DT cord-347946-i6kx3n6m 239 3 other other JJ cord-347946-i6kx3n6m 239 4 hand hand NN cord-347946-i6kx3n6m 239 5 , , , cord-347946-i6kx3n6m 239 6 their -PRON- PRP$ cord-347946-i6kx3n6m 239 7 presence presence NN cord-347946-i6kx3n6m 239 8 in in IN cord-347946-i6kx3n6m 239 9 MDD MDD NNP cord-347946-i6kx3n6m 239 10 is be VBZ cord-347946-i6kx3n6m 239 11 not not RB cord-347946-i6kx3n6m 239 12 parsimoniously parsimoniously RB cord-347946-i6kx3n6m 239 13 explained explain VBN cord-347946-i6kx3n6m 239 14 by by IN cord-347946-i6kx3n6m 239 15 theories theory NNS cord-347946-i6kx3n6m 239 16 that that WDT cord-347946-i6kx3n6m 239 17 focus focus VBP cord-347946-i6kx3n6m 239 18 on on IN cord-347946-i6kx3n6m 239 19 potential potential JJ cord-347946-i6kx3n6m 239 20 social social JJ cord-347946-i6kx3n6m 239 21 benefits benefit NNS cord-347946-i6kx3n6m 239 22 of of IN cord-347946-i6kx3n6m 239 23 depression depression NN cord-347946-i6kx3n6m 239 24 . . . cord-347946-i6kx3n6m 240 1 In in IN cord-347946-i6kx3n6m 240 2 what what WDT cord-347946-i6kx3n6m 240 3 ways way NNS cord-347946-i6kx3n6m 240 4 would would MD cord-347946-i6kx3n6m 240 5 elevated elevated VB cord-347946-i6kx3n6m 240 6 body body NN cord-347946-i6kx3n6m 240 7 temperature temperature NN cord-347946-i6kx3n6m 240 8 or or CC cord-347946-i6kx3n6m 240 9 reduced reduce VBN cord-347946-i6kx3n6m 240 10 iron iron NN cord-347946-i6kx3n6m 240 11 availability availability NN cord-347946-i6kx3n6m 240 12 aid aid NN cord-347946-i6kx3n6m 240 13 in in IN cord-347946-i6kx3n6m 240 14 negotiating negotiate VBG cord-347946-i6kx3n6m 240 15 relationships relationship NNS cord-347946-i6kx3n6m 240 16 with with IN cord-347946-i6kx3n6m 240 17 other other JJ cord-347946-i6kx3n6m 240 18 humans human NNS cord-347946-i6kx3n6m 240 19 ? ? . cord-347946-i6kx3n6m 241 1 Similarly similarly RB cord-347946-i6kx3n6m 241 2 , , , cord-347946-i6kx3n6m 241 3 if if IN cord-347946-i6kx3n6m 241 4 depression depression NN cord-347946-i6kx3n6m 241 5 is be VBZ cord-347946-i6kx3n6m 241 6 simply simply RB cord-347946-i6kx3n6m 241 7 a a DT cord-347946-i6kx3n6m 241 8 non non JJ cord-347946-i6kx3n6m 241 9 - - JJ cord-347946-i6kx3n6m 241 10 adaptive adaptive JJ cord-347946-i6kx3n6m 241 11 phenomenon phenomenon NN cord-347946-i6kx3n6m 241 12 , , , cord-347946-i6kx3n6m 241 13 why why WRB cord-347946-i6kx3n6m 241 14 would would MD cord-347946-i6kx3n6m 241 15 such such JJ cord-347946-i6kx3n6m 241 16 ancient ancient JJ cord-347946-i6kx3n6m 241 17 , , , cord-347946-i6kx3n6m 241 18 highly highly RB cord-347946-i6kx3n6m 241 19 conserved conserved JJ cord-347946-i6kx3n6m 241 20 and and CC cord-347946-i6kx3n6m 241 21 highly highly RB cord-347946-i6kx3n6m 241 22 complex complex JJ cord-347946-i6kx3n6m 241 23 physiological physiological JJ cord-347946-i6kx3n6m 241 24 responses response NNS cord-347946-i6kx3n6m 241 25 be be VB cord-347946-i6kx3n6m 241 26 associated associate VBN cord-347946-i6kx3n6m 241 27 with with IN cord-347946-i6kx3n6m 241 28 the the DT cord-347946-i6kx3n6m 241 29 disorder disorder NN cord-347946-i6kx3n6m 241 30 ? ? . cord-347946-i6kx3n6m 242 1 Inseparable inseparable JJ cord-347946-i6kx3n6m 242 2 from from IN cord-347946-i6kx3n6m 242 3 the the DT cord-347946-i6kx3n6m 242 4 physiological physiological JJ cord-347946-i6kx3n6m 242 5 aspects aspect NNS cord-347946-i6kx3n6m 242 6 of of IN cord-347946-i6kx3n6m 242 7 the the DT cord-347946-i6kx3n6m 242 8 APR APR NNP cord-347946-i6kx3n6m 242 9 , , , cord-347946-i6kx3n6m 242 10 immune immune JJ cord-347946-i6kx3n6m 242 11 activation activation NN cord-347946-i6kx3n6m 242 12 also also RB cord-347946-i6kx3n6m 242 13 produces produce VBZ cord-347946-i6kx3n6m 242 14 a a DT cord-347946-i6kx3n6m 242 15 suite suite NN cord-347946-i6kx3n6m 242 16 of of IN cord-347946-i6kx3n6m 242 17 behavioral behavioral JJ cord-347946-i6kx3n6m 242 18 responses response NNS cord-347946-i6kx3n6m 242 19 known know VBN cord-347946-i6kx3n6m 242 20 as as IN cord-347946-i6kx3n6m 242 21 sickness sickness NN cord-347946-i6kx3n6m 242 22 behavior behavior NN cord-347946-i6kx3n6m 242 23 that that WDT cord-347946-i6kx3n6m 242 24 has have VBZ cord-347946-i6kx3n6m 242 25 been be VBN cord-347946-i6kx3n6m 242 26 retained retain VBN cord-347946-i6kx3n6m 242 27 across across IN cord-347946-i6kx3n6m 242 28 vertebrate vertebrate JJ cord-347946-i6kx3n6m 242 29 evolution evolution NN cord-347946-i6kx3n6m 242 30 and and CC cord-347946-i6kx3n6m 242 31 that that DT cord-347946-i6kx3n6m 242 32 shares share VBZ cord-347946-i6kx3n6m 242 33 many many JJ cord-347946-i6kx3n6m 242 34 features feature NNS cord-347946-i6kx3n6m 242 35 in in IN cord-347946-i6kx3n6m 242 36 common common JJ cord-347946-i6kx3n6m 242 37 with with IN cord-347946-i6kx3n6m 242 38 the the DT cord-347946-i6kx3n6m 242 39 symptoms symptom NNS cord-347946-i6kx3n6m 242 40 of of IN cord-347946-i6kx3n6m 242 41 MDD MDD NNP cord-347946-i6kx3n6m 242 42 ( ( -LRB- cord-347946-i6kx3n6m 242 43 Dantzer Dantzer NNP cord-347946-i6kx3n6m 242 44 , , , cord-347946-i6kx3n6m 242 45 2006 2006 CD cord-347946-i6kx3n6m 242 46 ; ; : cord-347946-i6kx3n6m 242 47 Dantzer Dantzer NNP cord-347946-i6kx3n6m 242 48 et et FW cord-347946-i6kx3n6m 242 49 al al NNP cord-347946-i6kx3n6m 242 50 , , , cord-347946-i6kx3n6m 242 51 2008b 2008b CD cord-347946-i6kx3n6m 242 52 ) ) -RRB- cord-347946-i6kx3n6m 242 53 . . . cord-347946-i6kx3n6m 243 1 These these DT cord-347946-i6kx3n6m 243 2 symptoms symptom NNS cord-347946-i6kx3n6m 243 3 include include VBP cord-347946-i6kx3n6m 243 4 lethargy/ lethargy/ CD cord-347946-i6kx3n6m 243 5 fatigue fatigue NN cord-347946-i6kx3n6m 243 6 , , , cord-347946-i6kx3n6m 243 7 psychomotor psychomotor NN cord-347946-i6kx3n6m 243 8 slowing slow VBG cord-347946-i6kx3n6m 243 9 , , , cord-347946-i6kx3n6m 243 10 altered alter VBN cord-347946-i6kx3n6m 243 11 sleep sleep NN cord-347946-i6kx3n6m 243 12 , , , cord-347946-i6kx3n6m 243 13 loss loss NN cord-347946-i6kx3n6m 243 14 of of IN cord-347946-i6kx3n6m 243 15 appetite appetite NN cord-347946-i6kx3n6m 243 16 , , , cord-347946-i6kx3n6m 243 17 anhedonia anhedonia NN cord-347946-i6kx3n6m 243 18 , , , cord-347946-i6kx3n6m 243 19 and and CC cord-347946-i6kx3n6m 243 20 social social JJ cord-347946-i6kx3n6m 243 21 withdrawal withdrawal NN cord-347946-i6kx3n6m 243 22 . . . cord-347946-i6kx3n6m 244 1 Although although IN cord-347946-i6kx3n6m 244 2 it -PRON- PRP cord-347946-i6kx3n6m 244 3 is be VBZ cord-347946-i6kx3n6m 244 4 clear clear JJ cord-347946-i6kx3n6m 244 5 that that IN cord-347946-i6kx3n6m 244 6 the the DT cord-347946-i6kx3n6m 244 7 symptoms symptom NNS cord-347946-i6kx3n6m 244 8 of of IN cord-347946-i6kx3n6m 244 9 depression depression NN cord-347946-i6kx3n6m 244 10 can can MD cord-347946-i6kx3n6m 244 11 arise arise VB cord-347946-i6kx3n6m 244 12 from from IN cord-347946-i6kx3n6m 244 13 a a DT cord-347946-i6kx3n6m 244 14 wide wide JJ cord-347946-i6kx3n6m 244 15 variety variety NN cord-347946-i6kx3n6m 244 16 of of IN cord-347946-i6kx3n6m 244 17 divergent divergent JJ cord-347946-i6kx3n6m 244 18 causes cause NNS cord-347946-i6kx3n6m 244 19 - - : cord-347946-i6kx3n6m 244 20 including include VBG cord-347946-i6kx3n6m 244 21 internally internally RB cord-347946-i6kx3n6m 244 22 generated generate VBN cord-347946-i6kx3n6m 244 23 thought thought NN cord-347946-i6kx3n6m 244 24 patterns pattern NNS cord-347946-i6kx3n6m 244 25 - - HYPH cord-347946-i6kx3n6m 244 26 PATHOS pathos NN cord-347946-i6kx3n6m 244 27 - - HYPH cord-347946-i6kx3n6m 244 28 D D NNP cord-347946-i6kx3n6m 244 29 proposes propose VBZ cord-347946-i6kx3n6m 244 30 that that IN cord-347946-i6kx3n6m 244 31 MDD MDD NNP cord-347946-i6kx3n6m 244 32 initially initially RB cord-347946-i6kx3n6m 244 33 evolved evolve VBD cord-347946-i6kx3n6m 244 34 out out IN cord-347946-i6kx3n6m 244 35 of of IN cord-347946-i6kx3n6m 244 36 sickness sickness NN cord-347946-i6kx3n6m 244 37 behavior behavior NN cord-347946-i6kx3n6m 244 38 . . . cord-347946-i6kx3n6m 245 1 Circumstantial circumstantial JJ cord-347946-i6kx3n6m 245 2 evidence evidence NN cord-347946-i6kx3n6m 245 3 for for IN cord-347946-i6kx3n6m 245 4 this this DT cord-347946-i6kx3n6m 245 5 type type NN cord-347946-i6kx3n6m 245 6 of of IN cord-347946-i6kx3n6m 245 7 close close JJ cord-347946-i6kx3n6m 245 8 relationship relationship NN cord-347946-i6kx3n6m 245 9 between between IN cord-347946-i6kx3n6m 245 10 sickness sickness NN cord-347946-i6kx3n6m 245 11 and and CC cord-347946-i6kx3n6m 245 12 MDD MDD NNP cord-347946-i6kx3n6m 245 13 come come VBP cord-347946-i6kx3n6m 245 14 from from IN cord-347946-i6kx3n6m 245 15 several several JJ cord-347946-i6kx3n6m 245 16 sources source NNS cord-347946-i6kx3n6m 245 17 . . . cord-347946-i6kx3n6m 246 1 For for IN cord-347946-i6kx3n6m 246 2 example example NN cord-347946-i6kx3n6m 246 3 , , , cord-347946-i6kx3n6m 246 4 data datum NNS cord-347946-i6kx3n6m 246 5 suggest suggest VBP cord-347946-i6kx3n6m 246 6 that that IN cord-347946-i6kx3n6m 246 7 many many JJ cord-347946-i6kx3n6m 246 8 people people NNS cord-347946-i6kx3n6m 246 9 can can MD cord-347946-i6kx3n6m 246 10 not not RB cord-347946-i6kx3n6m 246 11 accurately accurately RB cord-347946-i6kx3n6m 246 12 identify identify VB cord-347946-i6kx3n6m 246 13 whether whether IN cord-347946-i6kx3n6m 246 14 they -PRON- PRP cord-347946-i6kx3n6m 246 15 are be VBP cord-347946-i6kx3n6m 246 16 developing develop VBG cord-347946-i6kx3n6m 246 17 depression depression NN cord-347946-i6kx3n6m 246 18 or or CC cord-347946-i6kx3n6m 246 19 an an DT cord-347946-i6kx3n6m 246 20 infectious infectious JJ cord-347946-i6kx3n6m 246 21 illness illness NN cord-347946-i6kx3n6m 246 22 early early RB cord-347946-i6kx3n6m 246 23 in in IN cord-347946-i6kx3n6m 246 24 the the DT cord-347946-i6kx3n6m 246 25 course course NN cord-347946-i6kx3n6m 246 26 of of IN cord-347946-i6kx3n6m 246 27 either either DT cord-347946-i6kx3n6m 246 28 condition condition NN cord-347946-i6kx3n6m 246 29 ( ( -LRB- cord-347946-i6kx3n6m 246 30 Ratcliffe Ratcliffe NNP cord-347946-i6kx3n6m 246 31 , , , cord-347946-i6kx3n6m 246 32 2013 2013 CD cord-347946-i6kx3n6m 246 33 ) ) -RRB- cord-347946-i6kx3n6m 246 34 . . . cord-347946-i6kx3n6m 247 1 Similarly similarly RB cord-347946-i6kx3n6m 247 2 , , , cord-347946-i6kx3n6m 247 3 sickness sickness NN cord-347946-i6kx3n6m 247 4 in in IN cord-347946-i6kx3n6m 247 5 the the DT cord-347946-i6kx3n6m 247 6 first first JJ cord-347946-i6kx3n6m 247 7 week week NN cord-347946-i6kx3n6m 247 8 of of IN cord-347946-i6kx3n6m 247 9 treatment treatment NN cord-347946-i6kx3n6m 247 10 with with IN cord-347946-i6kx3n6m 247 11 the the DT cord-347946-i6kx3n6m 247 12 cytokine cytokine NN cord-347946-i6kx3n6m 247 13 IFN IFN NNP cord-347946-i6kx3n6m 247 14 - - HYPH cord-347946-i6kx3n6m 247 15 α α NNP cord-347946-i6kx3n6m 247 16 strongly strongly RB cord-347946-i6kx3n6m 247 17 predicts predict VBZ cord-347946-i6kx3n6m 247 18 the the DT cord-347946-i6kx3n6m 247 19 development development NN cord-347946-i6kx3n6m 247 20 of of IN cord-347946-i6kx3n6m 247 21 cognitive cognitive JJ cord-347946-i6kx3n6m 247 22 / / SYM cord-347946-i6kx3n6m 247 23 emotional emotional JJ cord-347946-i6kx3n6m 247 24 symptoms symptom NNS cord-347946-i6kx3n6m 247 25 of of IN cord-347946-i6kx3n6m 247 26 depression depression NN cord-347946-i6kx3n6m 247 27 over over IN cord-347946-i6kx3n6m 247 28 the the DT cord-347946-i6kx3n6m 247 29 ensuing ensue VBG cord-347946-i6kx3n6m 247 30 6 6 CD cord-347946-i6kx3n6m 247 31 months month NNS cord-347946-i6kx3n6m 247 32 of of IN cord-347946-i6kx3n6m 247 33 therapy therapy NN cord-347946-i6kx3n6m 247 34 ( ( -LRB- cord-347946-i6kx3n6m 247 35 Wichers Wichers NNP cord-347946-i6kx3n6m 247 36 et et NNP cord-347946-i6kx3n6m 247 37 al al NNP cord-347946-i6kx3n6m 247 38 , , , cord-347946-i6kx3n6m 247 39 2005a 2005a CD cord-347946-i6kx3n6m 247 40 ) ) -RRB- cord-347946-i6kx3n6m 247 41 . . . cord-347946-i6kx3n6m 248 1 Finally finally RB cord-347946-i6kx3n6m 248 2 , , , cord-347946-i6kx3n6m 248 3 if if IN cord-347946-i6kx3n6m 248 4 inflammation inflammation NN cord-347946-i6kx3n6m 248 5 induces induce VBZ cord-347946-i6kx3n6m 248 6 sickness sickness NN cord-347946-i6kx3n6m 248 7 and and CC cord-347946-i6kx3n6m 248 8 if if IN cord-347946-i6kx3n6m 248 9 depression depression NN cord-347946-i6kx3n6m 248 10 evolved evolve VBD cord-347946-i6kx3n6m 248 11 out out IN cord-347946-i6kx3n6m 248 12 of of IN cord-347946-i6kx3n6m 248 13 sickness sickness NN cord-347946-i6kx3n6m 248 14 , , , cord-347946-i6kx3n6m 248 15 inflammation inflammation NN cord-347946-i6kx3n6m 248 16 might may MD cord-347946-i6kx3n6m 248 17 be be VB cord-347946-i6kx3n6m 248 18 expected expect VBN cord-347946-i6kx3n6m 248 19 to to TO cord-347946-i6kx3n6m 248 20 be be VB cord-347946-i6kx3n6m 248 21 more more RBR cord-347946-i6kx3n6m 248 22 strongly strongly RB cord-347946-i6kx3n6m 248 23 associated associate VBN cord-347946-i6kx3n6m 248 24 with with IN cord-347946-i6kx3n6m 248 25 the the DT cord-347946-i6kx3n6m 248 26 symptoms symptom NNS cord-347946-i6kx3n6m 248 27 most most RBS cord-347946-i6kx3n6m 248 28 often often RB cord-347946-i6kx3n6m 248 29 shared share VBN cord-347946-i6kx3n6m 248 30 by by IN cord-347946-i6kx3n6m 248 31 sickness sickness NN cord-347946-i6kx3n6m 248 32 and and CC cord-347946-i6kx3n6m 248 33 depression depression NN cord-347946-i6kx3n6m 248 34 , , , cord-347946-i6kx3n6m 248 35 rather rather RB cord-347946-i6kx3n6m 248 36 than than IN cord-347946-i6kx3n6m 248 37 symptoms symptom NNS cord-347946-i6kx3n6m 248 38 such such JJ cord-347946-i6kx3n6m 248 39 as as IN cord-347946-i6kx3n6m 248 40 sadness sadness NN cord-347946-i6kx3n6m 248 41 and and CC cord-347946-i6kx3n6m 248 42 guilt guilt NN cord-347946-i6kx3n6m 248 43 / / SYM cord-347946-i6kx3n6m 248 44 feelings feeling NNS cord-347946-i6kx3n6m 248 45 of of IN cord-347946-i6kx3n6m 248 46 worthlessness worthlessness NN cord-347946-i6kx3n6m 248 47 that that WDT cord-347946-i6kx3n6m 248 48 are be VBP cord-347946-i6kx3n6m 248 49 more more RBR cord-347946-i6kx3n6m 248 50 specific specific JJ cord-347946-i6kx3n6m 248 51 to to IN cord-347946-i6kx3n6m 248 52 MDD MDD NNP cord-347946-i6kx3n6m 248 53 . . . cord-347946-i6kx3n6m 249 1 Supporting support VBG cord-347946-i6kx3n6m 249 2 this this DT cord-347946-i6kx3n6m 249 3 possibility possibility NN cord-347946-i6kx3n6m 249 4 , , , cord-347946-i6kx3n6m 249 5 an an DT cord-347946-i6kx3n6m 249 6 early early JJ cord-347946-i6kx3n6m 249 7 report report NN cord-347946-i6kx3n6m 249 8 found find VBD cord-347946-i6kx3n6m 249 9 that that IN cord-347946-i6kx3n6m 249 10 the the DT cord-347946-i6kx3n6m 249 11 acute acute JJ cord-347946-i6kx3n6m 249 12 phase phase NN cord-347946-i6kx3n6m 249 13 protein protein NN cord-347946-i6kx3n6m 249 14 haptoglobin haptoglobin NN cord-347946-i6kx3n6m 249 15 correlated correlate VBN cord-347946-i6kx3n6m 249 16 with with IN cord-347946-i6kx3n6m 249 17 psychomotor psychomotor JJ cord-347946-i6kx3n6m 249 18 retardation retardation NN cord-347946-i6kx3n6m 249 19 , , , cord-347946-i6kx3n6m 249 20 sleep sleep NN cord-347946-i6kx3n6m 249 21 disturbance disturbance NN cord-347946-i6kx3n6m 249 22 , , , cord-347946-i6kx3n6m 249 23 anorexia anorexia NN cord-347946-i6kx3n6m 249 24 / / SYM cord-347946-i6kx3n6m 249 25 weight weight NN cord-347946-i6kx3n6m 249 26 loss loss NN cord-347946-i6kx3n6m 249 27 , , , cord-347946-i6kx3n6m 249 28 and and CC cord-347946-i6kx3n6m 249 29 anhedonia anhedonia FW cord-347946-i6kx3n6m 249 30 ( ( -LRB- cord-347946-i6kx3n6m 249 31 Maes Maes NNP cord-347946-i6kx3n6m 249 32 et et NNP cord-347946-i6kx3n6m 249 33 al al NNP cord-347946-i6kx3n6m 249 34 , , , cord-347946-i6kx3n6m 249 35 1993 1993 CD cord-347946-i6kx3n6m 249 36 ) ) -RRB- cord-347946-i6kx3n6m 249 37 . . . cord-347946-i6kx3n6m 250 1 More more RBR cord-347946-i6kx3n6m 250 2 recently recently RB cord-347946-i6kx3n6m 250 3 , , , cord-347946-i6kx3n6m 250 4 a a DT cord-347946-i6kx3n6m 250 5 large large JJ cord-347946-i6kx3n6m 250 6 population population NN cord-347946-i6kx3n6m 250 7 - - HYPH cord-347946-i6kx3n6m 250 8 based base VBN cord-347946-i6kx3n6m 250 9 study study NN cord-347946-i6kx3n6m 250 10 ( ( -LRB- cord-347946-i6kx3n6m 250 11 N n NN cord-347946-i6kx3n6m 250 12 = = SYM cord-347946-i6kx3n6m 250 13 15 15 CD cord-347946-i6kx3n6m 250 14 071 071 CD cord-347946-i6kx3n6m 250 15 ) ) -RRB- cord-347946-i6kx3n6m 250 16 reported report VBD cord-347946-i6kx3n6m 250 17 that that IN cord-347946-i6kx3n6m 250 18 CRP CRP NNP cord-347946-i6kx3n6m 250 19 was be VBD cord-347946-i6kx3n6m 250 20 more more RBR cord-347946-i6kx3n6m 250 21 strongly strongly RB cord-347946-i6kx3n6m 250 22 associated associate VBN cord-347946-i6kx3n6m 250 23 with with IN cord-347946-i6kx3n6m 250 24 sleep sleep NN cord-347946-i6kx3n6m 250 25 abnormalities abnormality NNS cord-347946-i6kx3n6m 250 26 , , , cord-347946-i6kx3n6m 250 27 fatigue fatigue NN cord-347946-i6kx3n6m 250 28 , , , cord-347946-i6kx3n6m 250 29 and and CC cord-347946-i6kx3n6m 250 30 appetite appetite NN cord-347946-i6kx3n6m 250 31 changes change NNS cord-347946-i6kx3n6m 250 32 than than IN cord-347946-i6kx3n6m 250 33 with with IN cord-347946-i6kx3n6m 250 34 MDD MDD NNP cord-347946-i6kx3n6m 250 35 symptoms symptom NNS cord-347946-i6kx3n6m 250 36 less less RBR cord-347946-i6kx3n6m 250 37 common common JJ cord-347946-i6kx3n6m 250 38 in in IN cord-347946-i6kx3n6m 250 39 the the DT cord-347946-i6kx3n6m 250 40 context context NN cord-347946-i6kx3n6m 250 41 of of IN cord-347946-i6kx3n6m 250 42 sickness sickness NN cord-347946-i6kx3n6m 251 1 ( ( -LRB- cord-347946-i6kx3n6m 251 2 Jokela Jokela NNP cord-347946-i6kx3n6m 251 3 et et NNP cord-347946-i6kx3n6m 251 4 al al NNP cord-347946-i6kx3n6m 251 5 , , , cord-347946-i6kx3n6m 251 6 2016 2016 CD cord-347946-i6kx3n6m 251 7 ) ) -RRB- cord-347946-i6kx3n6m 251 8 . . . cord-347946-i6kx3n6m 252 1 In in IN cord-347946-i6kx3n6m 252 2 a a DT cord-347946-i6kx3n6m 252 3 group group NN cord-347946-i6kx3n6m 252 4 of of IN cord-347946-i6kx3n6m 252 5 patients patient NNS cord-347946-i6kx3n6m 252 6 with with IN cord-347946-i6kx3n6m 252 7 MDD MDD NNP cord-347946-i6kx3n6m 252 8 , , , cord-347946-i6kx3n6m 252 9 increased increase VBN cord-347946-i6kx3n6m 252 10 circulating circulate VBG cord-347946-i6kx3n6m 252 11 levels level NNS cord-347946-i6kx3n6m 252 12 of of IN cord-347946-i6kx3n6m 252 13 IL-6 IL-6 NNP cord-347946-i6kx3n6m 252 14 and and CC cord-347946-i6kx3n6m 252 15 monocyte monocyte NNP cord-347946-i6kx3n6m 252 16 chemoattractant chemoattractant NNP cord-347946-i6kx3n6m 252 17 protein-1 protein-1 NNP cord-347946-i6kx3n6m 252 18 were be VBD cord-347946-i6kx3n6m 252 19 positively positively RB cord-347946-i6kx3n6m 252 20 associated associate VBN cord-347946-i6kx3n6m 252 21 ( ( -LRB- cord-347946-i6kx3n6m 252 22 and and CC cord-347946-i6kx3n6m 252 23 levels level NNS cord-347946-i6kx3n6m 252 24 of of IN cord-347946-i6kx3n6m 252 25 IL-10 IL-10 NNP cord-347946-i6kx3n6m 252 26 were be VBD cord-347946-i6kx3n6m 252 27 negatively negatively RB cord-347946-i6kx3n6m 252 28 associated associate VBN cord-347946-i6kx3n6m 252 29 ) ) -RRB- cord-347946-i6kx3n6m 252 30 with with IN cord-347946-i6kx3n6m 252 31 objectively objectively RB cord-347946-i6kx3n6m 252 32 measured measure VBN cord-347946-i6kx3n6m 252 33 psychomotor psychomotor NN cord-347946-i6kx3n6m 252 34 slowing slow VBG cord-347946-i6kx3n6m 252 35 ( ( -LRB- cord-347946-i6kx3n6m 252 36 Goldsmith Goldsmith NNP cord-347946-i6kx3n6m 252 37 et et FW cord-347946-i6kx3n6m 252 38 al al NNP cord-347946-i6kx3n6m 252 39 , , , cord-347946-i6kx3n6m 252 40 2016a 2016a CD cord-347946-i6kx3n6m 252 41 ) ) -RRB- cord-347946-i6kx3n6m 252 42 , , , cord-347946-i6kx3n6m 252 43 and and CC cord-347946-i6kx3n6m 252 44 elevated elevated JJ cord-347946-i6kx3n6m 252 45 plasma plasma NN cord-347946-i6kx3n6m 252 46 CRP crp NN cord-347946-i6kx3n6m 252 47 was be VBD cord-347946-i6kx3n6m 252 48 associated associate VBN cord-347946-i6kx3n6m 252 49 with with IN cord-347946-i6kx3n6m 252 50 reduced reduce VBN cord-347946-i6kx3n6m 252 51 functional functional JJ cord-347946-i6kx3n6m 252 52 connectivity connectivity NN cord-347946-i6kx3n6m 252 53 between between IN cord-347946-i6kx3n6m 252 54 the the DT cord-347946-i6kx3n6m 252 55 ventromedial ventromedial JJ cord-347946-i6kx3n6m 252 56 prefrontal prefrontal JJ cord-347946-i6kx3n6m 252 57 cortex cortex NNS cord-347946-i6kx3n6m 252 58 and and CC cord-347946-i6kx3n6m 252 59 ventral ventral JJ cord-347946-i6kx3n6m 252 60 striatum striatum NN cord-347946-i6kx3n6m 252 61 . . . cord-347946-i6kx3n6m 253 1 These these DT cord-347946-i6kx3n6m 253 2 changes change NNS cord-347946-i6kx3n6m 253 3 in in IN cord-347946-i6kx3n6m 253 4 functional functional JJ cord-347946-i6kx3n6m 253 5 connectivity connectivity NN cord-347946-i6kx3n6m 253 6 mediated mediate VBN cord-347946-i6kx3n6m 253 7 associations association NNS cord-347946-i6kx3n6m 253 8 between between IN cord-347946-i6kx3n6m 253 9 increased increase VBN cord-347946-i6kx3n6m 253 10 CRP CRP NNP cord-347946-i6kx3n6m 253 11 and and CC cord-347946-i6kx3n6m 253 12 anhedonia anhedonia NN cord-347946-i6kx3n6m 253 13 and and CC cord-347946-i6kx3n6m 253 14 psychomotor psychomotor NN cord-347946-i6kx3n6m 253 15 slowing slow VBG cord-347946-i6kx3n6m 253 16 ( ( -LRB- cord-347946-i6kx3n6m 253 17 Felger Felger NNP cord-347946-i6kx3n6m 253 18 et et NNP cord-347946-i6kx3n6m 253 19 al al NNP cord-347946-i6kx3n6m 253 20 , , , cord-347946-i6kx3n6m 253 21 2015 2015 CD cord-347946-i6kx3n6m 253 22 ) ) -RRB- cord-347946-i6kx3n6m 253 23 . . . cord-347946-i6kx3n6m 254 1 Evolutionary evolutionary JJ cord-347946-i6kx3n6m 254 2 processes process NNS cord-347946-i6kx3n6m 254 3 do do VBP cord-347946-i6kx3n6m 254 4 not not RB cord-347946-i6kx3n6m 254 5 produce produce VB cord-347946-i6kx3n6m 254 6 perfect perfect JJ cord-347946-i6kx3n6m 254 7 products product NNS cord-347946-i6kx3n6m 254 8 , , , cord-347946-i6kx3n6m 254 9 and and CC cord-347946-i6kx3n6m 254 10 all all DT cord-347946-i6kx3n6m 254 11 evolved evolve VBN cord-347946-i6kx3n6m 254 12 adaptive adaptive JJ cord-347946-i6kx3n6m 254 13 mechanisms mechanism NNS cord-347946-i6kx3n6m 254 14 come come VBP cord-347946-i6kx3n6m 254 15 with with IN cord-347946-i6kx3n6m 254 16 associated associate VBN cord-347946-i6kx3n6m 254 17 costs cost NNS cord-347946-i6kx3n6m 254 18 and and CC cord-347946-i6kx3n6m 254 19 trade trade NN cord-347946-i6kx3n6m 254 20 - - HYPH cord-347946-i6kx3n6m 254 21 offs off NNS cord-347946-i6kx3n6m 254 22 . . . cord-347946-i6kx3n6m 255 1 If if IN cord-347946-i6kx3n6m 255 2 indeed indeed RB cord-347946-i6kx3n6m 255 3 MDD MDD NNP cord-347946-i6kx3n6m 255 4 is be VBZ cord-347946-i6kx3n6m 255 5 conceptualized conceptualize VBN cord-347946-i6kx3n6m 255 6 as as IN cord-347946-i6kx3n6m 255 7 a a DT cord-347946-i6kx3n6m 255 8 condition condition NN cord-347946-i6kx3n6m 255 9 evolved evolve VBN cord-347946-i6kx3n6m 255 10 from from IN cord-347946-i6kx3n6m 255 11 , , , cord-347946-i6kx3n6m 255 12 and and CC cord-347946-i6kx3n6m 255 13 ' ' `` cord-347946-i6kx3n6m 255 14 designed design VBN cord-347946-i6kx3n6m 255 15 ' ' '' cord-347946-i6kx3n6m 255 16 to to TO cord-347946-i6kx3n6m 255 17 serve serve VB cord-347946-i6kx3n6m 255 18 the the DT cord-347946-i6kx3n6m 255 19 same same JJ cord-347946-i6kx3n6m 255 20 purposes purpose NNS cord-347946-i6kx3n6m 255 21 as as IN cord-347946-i6kx3n6m 255 22 , , , cord-347946-i6kx3n6m 255 23 sickness sickness NN cord-347946-i6kx3n6m 255 24 , , , cord-347946-i6kx3n6m 255 25 the the DT cord-347946-i6kx3n6m 255 26 obvious obvious JJ cord-347946-i6kx3n6m 255 27 question question NN cord-347946-i6kx3n6m 255 28 is be VBZ cord-347946-i6kx3n6m 255 29 what what WP cord-347946-i6kx3n6m 255 30 pathogen pathogen NN cord-347946-i6kx3n6m 255 31 - - HYPH cord-347946-i6kx3n6m 255 32 related relate VBN cord-347946-i6kx3n6m 255 33 survival survival NN cord-347946-i6kx3n6m 255 34 and and CC cord-347946-i6kx3n6m 255 35 reproductive reproductive JJ cord-347946-i6kx3n6m 255 36 benefits benefit NNS cord-347946-i6kx3n6m 255 37 accrue accrue VBP cord-347946-i6kx3n6m 255 38 from from IN cord-347946-i6kx3n6m 255 39 depressive depressive JJ cord-347946-i6kx3n6m 255 40 symptoms symptom NNS cord-347946-i6kx3n6m 255 41 that that WDT cord-347946-i6kx3n6m 255 42 offset offset VBP cord-347946-i6kx3n6m 255 43 their -PRON- PRP$ cord-347946-i6kx3n6m 255 44 costs cost NNS cord-347946-i6kx3n6m 255 45 . . . cord-347946-i6kx3n6m 256 1 That that DT cord-347946-i6kx3n6m 256 2 depression depression NN cord-347946-i6kx3n6m 256 3 reduces reduce VBZ cord-347946-i6kx3n6m 256 4 fitness fitness NN cord-347946-i6kx3n6m 256 5 in in IN cord-347946-i6kx3n6m 256 6 modern modern JJ cord-347946-i6kx3n6m 256 7 environments environment NNS cord-347946-i6kx3n6m 256 8 has have VBZ cord-347946-i6kx3n6m 256 9 often often RB cord-347946-i6kx3n6m 256 10 been be VBN cord-347946-i6kx3n6m 256 11 remarked remark VBN cord-347946-i6kx3n6m 256 12 upon upon IN cord-347946-i6kx3n6m 256 13 ; ; : cord-347946-i6kx3n6m 256 14 however however RB cord-347946-i6kx3n6m 256 15 , , , cord-347946-i6kx3n6m 256 16 the the DT cord-347946-i6kx3n6m 256 17 costs cost NNS cord-347946-i6kx3n6m 256 18 across across IN cord-347946-i6kx3n6m 256 19 evolutionary evolutionary JJ cord-347946-i6kx3n6m 256 20 time time NN cord-347946-i6kx3n6m 256 21 of of IN cord-347946-i6kx3n6m 256 22 the the DT cord-347946-i6kx3n6m 256 23 types type NNS cord-347946-i6kx3n6m 256 24 of of IN cord-347946-i6kx3n6m 256 25 prolonged prolonged JJ cord-347946-i6kx3n6m 256 26 sickness sickness NN cord-347946-i6kx3n6m 256 27 behaviors behavior NNS cord-347946-i6kx3n6m 256 28 that that WDT cord-347946-i6kx3n6m 256 29 comprise comprise VBP cord-347946-i6kx3n6m 256 30 MDD MDD NNP cord-347946-i6kx3n6m 256 31 have have VBP cord-347946-i6kx3n6m 256 32 also also RB cord-347946-i6kx3n6m 256 33 likely likely RB cord-347946-i6kx3n6m 256 34 been be VBN cord-347946-i6kx3n6m 256 35 substantial substantial JJ cord-347946-i6kx3n6m 256 36 . . . cord-347946-i6kx3n6m 257 1 As as IN cord-347946-i6kx3n6m 257 2 part part NN cord-347946-i6kx3n6m 257 3 of of IN cord-347946-i6kx3n6m 257 4 the the DT cord-347946-i6kx3n6m 257 5 APR APR NNP cord-347946-i6kx3n6m 257 6 , , , cord-347946-i6kx3n6m 257 7 sickness sickness NN cord-347946-i6kx3n6m 257 8 exacts exact VBZ cord-347946-i6kx3n6m 257 9 significant significant JJ cord-347946-i6kx3n6m 257 10 metabolic metabolic JJ cord-347946-i6kx3n6m 257 11 costs cost NNS cord-347946-i6kx3n6m 257 12 that that WDT cord-347946-i6kx3n6m 257 13 limit limit VBP cord-347946-i6kx3n6m 257 14 energy energy NN cord-347946-i6kx3n6m 257 15 available available JJ cord-347946-i6kx3n6m 257 16 to to IN cord-347946-i6kx3n6m 257 17 other other JJ cord-347946-i6kx3n6m 257 18 tasks task NNS cord-347946-i6kx3n6m 257 19 essential essential JJ cord-347946-i6kx3n6m 257 20 for for IN cord-347946-i6kx3n6m 257 21 survival survival NN cord-347946-i6kx3n6m 257 22 and and CC cord-347946-i6kx3n6m 257 23 reproduction reproduction NN cord-347946-i6kx3n6m 257 24 . . . cord-347946-i6kx3n6m 258 1 In in IN cord-347946-i6kx3n6m 258 2 many many JJ cord-347946-i6kx3n6m 258 3 species specie NNS cord-347946-i6kx3n6m 258 4 , , , cord-347946-i6kx3n6m 258 5 including include VBG cord-347946-i6kx3n6m 258 6 humans human NNS cord-347946-i6kx3n6m 258 7 , , , cord-347946-i6kx3n6m 258 8 even even RB cord-347946-i6kx3n6m 258 9 subtle subtle JJ cord-347946-i6kx3n6m 258 10 signs sign NNS cord-347946-i6kx3n6m 258 11 of of IN cord-347946-i6kx3n6m 258 12 sickness sickness NN cord-347946-i6kx3n6m 258 13 promote promote VBP cord-347946-i6kx3n6m 258 14 avoidance avoidance NN cord-347946-i6kx3n6m 258 15 behavior behavior NN cord-347946-i6kx3n6m 258 16 from from IN cord-347946-i6kx3n6m 258 17 conspecifics conspecific NNS cord-347946-i6kx3n6m 258 18 ( ( -LRB- cord-347946-i6kx3n6m 258 19 Schaller Schaller NNP cord-347946-i6kx3n6m 258 20 , , , cord-347946-i6kx3n6m 258 21 2011 2011 CD cord-347946-i6kx3n6m 258 22 ) ) -RRB- cord-347946-i6kx3n6m 258 23 . . . cord-347946-i6kx3n6m 259 1 Over over IN cord-347946-i6kx3n6m 259 2 and and CC cord-347946-i6kx3n6m 259 3 above above IN cord-347946-i6kx3n6m 259 4 the the DT cord-347946-i6kx3n6m 259 5 suppressive suppressive JJ cord-347946-i6kx3n6m 259 6 effect effect NN cord-347946-i6kx3n6m 259 7 of of IN cord-347946-i6kx3n6m 259 8 inflammation inflammation NN cord-347946-i6kx3n6m 259 9 on on IN cord-347946-i6kx3n6m 259 10 sexual sexual JJ cord-347946-i6kx3n6m 259 11 functioning functioning NN cord-347946-i6kx3n6m 259 12 , , , cord-347946-i6kx3n6m 259 13 individuals individual NNS cord-347946-i6kx3n6m 259 14 who who WP cord-347946-i6kx3n6m 259 15 appear appear VBP cord-347946-i6kx3n6m 259 16 sick sick JJ cord-347946-i6kx3n6m 259 17 are be VBP cord-347946-i6kx3n6m 259 18 judged judge VBN cord-347946-i6kx3n6m 259 19 to to TO cord-347946-i6kx3n6m 259 20 be be VB cord-347946-i6kx3n6m 259 21 less less RBR cord-347946-i6kx3n6m 259 22 attractive attractive JJ cord-347946-i6kx3n6m 259 23 and and CC cord-347946-i6kx3n6m 259 24 hence hence RB cord-347946-i6kx3n6m 259 25 are be VBP cord-347946-i6kx3n6m 259 26 less less RBR cord-347946-i6kx3n6m 259 27 likely likely JJ cord-347946-i6kx3n6m 259 28 to to TO cord-347946-i6kx3n6m 259 29 find find VB cord-347946-i6kx3n6m 259 30 high high JJ cord-347946-i6kx3n6m 259 31 - - HYPH cord-347946-i6kx3n6m 259 32 quality quality NN cord-347946-i6kx3n6m 259 33 mates mate NNS cord-347946-i6kx3n6m 259 34 . . . cord-347946-i6kx3n6m 260 1 In in IN cord-347946-i6kx3n6m 260 2 hierarchical hierarchical JJ cord-347946-i6kx3n6m 260 3 social social JJ cord-347946-i6kx3n6m 260 4 groups group NNS cord-347946-i6kx3n6m 260 5 the the DT cord-347946-i6kx3n6m 260 6 display display NN cord-347946-i6kx3n6m 260 7 of of IN cord-347946-i6kx3n6m 260 8 sickness sickness NN cord-347946-i6kx3n6m 260 9 risks risk VBZ cord-347946-i6kx3n6m 260 10 loss loss NN cord-347946-i6kx3n6m 260 11 of of IN cord-347946-i6kx3n6m 260 12 social social JJ cord-347946-i6kx3n6m 260 13 status status NN cord-347946-i6kx3n6m 260 14 , , , cord-347946-i6kx3n6m 260 15 with with IN cord-347946-i6kx3n6m 260 16 associated associated JJ cord-347946-i6kx3n6m 260 17 reductions reduction NNS cord-347946-i6kx3n6m 260 18 in in IN cord-347946-i6kx3n6m 260 19 survival survival NN cord-347946-i6kx3n6m 260 20 and and CC cord-347946-i6kx3n6m 260 21 reproductive reproductive JJ cord-347946-i6kx3n6m 260 22 access access NN cord-347946-i6kx3n6m 260 23 . . . cord-347946-i6kx3n6m 261 1 Finally finally RB cord-347946-i6kx3n6m 261 2 , , , cord-347946-i6kx3n6m 261 3 sickness sickness NN cord-347946-i6kx3n6m 261 4 increases increase VBZ cord-347946-i6kx3n6m 261 5 the the DT cord-347946-i6kx3n6m 261 6 risk risk NN cord-347946-i6kx3n6m 261 7 of of IN cord-347946-i6kx3n6m 261 8 predation predation NN cord-347946-i6kx3n6m 261 9 ( ( -LRB- cord-347946-i6kx3n6m 261 10 Schaller Schaller NNP cord-347946-i6kx3n6m 261 11 , , , cord-347946-i6kx3n6m 261 12 2011 2011 CD cord-347946-i6kx3n6m 261 13 ) ) -RRB- cord-347946-i6kx3n6m 261 14 . . . cord-347946-i6kx3n6m 262 1 One one CD cord-347946-i6kx3n6m 262 2 possibility possibility NN cord-347946-i6kx3n6m 262 3 is be VBZ cord-347946-i6kx3n6m 262 4 that that IN cord-347946-i6kx3n6m 262 5 the the DT cord-347946-i6kx3n6m 262 6 PATHOS PATHOS NNP cord-347946-i6kx3n6m 262 7 - - HYPH cord-347946-i6kx3n6m 262 8 D d JJ cord-347946-i6kx3n6m 262 9 perspective perspective NN cord-347946-i6kx3n6m 262 10 is be VBZ cord-347946-i6kx3n6m 262 11 exactly exactly RB cord-347946-i6kx3n6m 262 12 backwards backwards JJ cord-347946-i6kx3n6m 262 13 , , , cord-347946-i6kx3n6m 262 14 and and CC cord-347946-i6kx3n6m 262 15 in in IN cord-347946-i6kx3n6m 262 16 fact fact NN cord-347946-i6kx3n6m 262 17 depression depression NN cord-347946-i6kx3n6m 262 18 is be VBZ cord-347946-i6kx3n6m 262 19 a a DT cord-347946-i6kx3n6m 262 20 maladaptive maladaptive JJ cord-347946-i6kx3n6m 262 21 consequence consequence NN cord-347946-i6kx3n6m 262 22 of of IN cord-347946-i6kx3n6m 262 23 the the DT cord-347946-i6kx3n6m 262 24 benefits benefit NNS cord-347946-i6kx3n6m 262 25 of of IN cord-347946-i6kx3n6m 262 26 acute acute JJ cord-347946-i6kx3n6m 262 27 sickness sickness NN cord-347946-i6kx3n6m 262 28 . . . cord-347946-i6kx3n6m 263 1 Perhaps perhaps RB cord-347946-i6kx3n6m 263 2 depression depression NN cord-347946-i6kx3n6m 263 3 is be VBZ cord-347946-i6kx3n6m 263 4 akin akin JJ cord-347946-i6kx3n6m 263 5 to to IN cord-347946-i6kx3n6m 263 6 other other JJ cord-347946-i6kx3n6m 263 7 chronic chronic JJ cord-347946-i6kx3n6m 263 8 conditions condition NNS cord-347946-i6kx3n6m 263 9 , , , cord-347946-i6kx3n6m 263 10 such such JJ cord-347946-i6kx3n6m 263 11 as as IN cord-347946-i6kx3n6m 263 12 HIV HIV NNP cord-347946-i6kx3n6m 263 13 and and CC cord-347946-i6kx3n6m 263 14 autoimmune autoimmune JJ cord-347946-i6kx3n6m 263 15 diseases disease NNS cord-347946-i6kx3n6m 263 16 , , , cord-347946-i6kx3n6m 263 17 in in IN cord-347946-i6kx3n6m 263 18 which which WDT cord-347946-i6kx3n6m 263 19 ongoing ongoing JJ cord-347946-i6kx3n6m 263 20 inflammation inflammation NN cord-347946-i6kx3n6m 263 21 , , , cord-347946-i6kx3n6m 263 22 rather rather RB cord-347946-i6kx3n6m 263 23 than than IN cord-347946-i6kx3n6m 263 24 providing provide VBG cord-347946-i6kx3n6m 263 25 benefit benefit NN cord-347946-i6kx3n6m 263 26 , , , cord-347946-i6kx3n6m 263 27 actually actually RB cord-347946-i6kx3n6m 263 28 increases increase VBZ cord-347946-i6kx3n6m 263 29 the the DT cord-347946-i6kx3n6m 263 30 risk risk NN cord-347946-i6kx3n6m 263 31 of of IN cord-347946-i6kx3n6m 263 32 infection infection NN cord-347946-i6kx3n6m 263 33 and/or and/or CC cord-347946-i6kx3n6m 263 34 infectious infectious JJ cord-347946-i6kx3n6m 263 35 mortality mortality NN cord-347946-i6kx3n6m 263 36 . . . cord-347946-i6kx3n6m 264 1 Many many JJ cord-347946-i6kx3n6m 264 2 studies study NNS cord-347946-i6kx3n6m 264 3 associating associate VBG cord-347946-i6kx3n6m 264 4 MDD MDD NNP cord-347946-i6kx3n6m 264 5 with with IN cord-347946-i6kx3n6m 264 6 increased increase VBN cord-347946-i6kx3n6m 264 7 infectious infectious JJ cord-347946-i6kx3n6m 264 8 morbidity morbidity NN cord-347946-i6kx3n6m 264 9 in in IN cord-347946-i6kx3n6m 264 10 the the DT cord-347946-i6kx3n6m 264 11 modern modern JJ cord-347946-i6kx3n6m 264 12 world world NN cord-347946-i6kx3n6m 264 13 would would MD cord-347946-i6kx3n6m 264 14 support support VB cord-347946-i6kx3n6m 264 15 this this DT cord-347946-i6kx3n6m 264 16 possibility possibility NN cord-347946-i6kx3n6m 264 17 ( ( -LRB- cord-347946-i6kx3n6m 264 18 Zorrilla Zorrilla NNP cord-347946-i6kx3n6m 264 19 et et FW cord-347946-i6kx3n6m 264 20 al al NNP cord-347946-i6kx3n6m 264 21 , , , cord-347946-i6kx3n6m 264 22 1996 1996 CD cord-347946-i6kx3n6m 264 23 ; ; : cord-347946-i6kx3n6m 264 24 Evans Evans NNP cord-347946-i6kx3n6m 264 25 et et NNP cord-347946-i6kx3n6m 264 26 al al NNP cord-347946-i6kx3n6m 264 27 , , , cord-347946-i6kx3n6m 264 28 2002 2002 CD cord-347946-i6kx3n6m 264 29 ; ; : cord-347946-i6kx3n6m 264 30 Cruess Cruess NNP cord-347946-i6kx3n6m 264 31 et et NNP cord-347946-i6kx3n6m 264 32 al al NNP cord-347946-i6kx3n6m 264 33 , , , cord-347946-i6kx3n6m 264 34 2003 2003 CD cord-347946-i6kx3n6m 264 35 ; ; : cord-347946-i6kx3n6m 264 36 Raison Raison NNP cord-347946-i6kx3n6m 264 37 et et NNP cord-347946-i6kx3n6m 264 38 al al NNP cord-347946-i6kx3n6m 264 39 , , , cord-347946-i6kx3n6m 264 40 2005 2005 CD cord-347946-i6kx3n6m 264 41 ; ; : cord-347946-i6kx3n6m 264 42 Doering Doering NNP cord-347946-i6kx3n6m 264 43 et et FW cord-347946-i6kx3n6m 264 44 al al NNP cord-347946-i6kx3n6m 264 45 , , , cord-347946-i6kx3n6m 264 46 2008 2008 CD cord-347946-i6kx3n6m 264 47 ; ; : cord-347946-i6kx3n6m 265 1 Faulkner Faulkner NNP cord-347946-i6kx3n6m 265 2 and and CC cord-347946-i6kx3n6m 265 3 Smith Smith NNP cord-347946-i6kx3n6m 265 4 , , , cord-347946-i6kx3n6m 265 5 2008 2008 CD cord-347946-i6kx3n6m 265 6 ; ; : cord-347946-i6kx3n6m 265 7 Leserman Leserman NNP cord-347946-i6kx3n6m 265 8 , , , cord-347946-i6kx3n6m 265 9 2008 2008 CD cord-347946-i6kx3n6m 265 10 ; ; : cord-347946-i6kx3n6m 265 11 Leutscher Leutscher NNP cord-347946-i6kx3n6m 265 12 et et NNP cord-347946-i6kx3n6m 265 13 al al NNP cord-347946-i6kx3n6m 265 14 , , , cord-347946-i6kx3n6m 265 15 2010 2010 CD cord-347946-i6kx3n6m 265 16 ; ; : cord-347946-i6kx3n6m 265 17 Andersson Andersson NNP cord-347946-i6kx3n6m 265 18 et et NNP cord-347946-i6kx3n6m 265 19 al al NNP cord-347946-i6kx3n6m 265 20 , , , cord-347946-i6kx3n6m 265 21 2016 2016 CD cord-347946-i6kx3n6m 265 22 ) ) -RRB- cord-347946-i6kx3n6m 265 23 . . . cord-347946-i6kx3n6m 266 1 If if IN cord-347946-i6kx3n6m 266 2 true true JJ cord-347946-i6kx3n6m 266 3 , , , cord-347946-i6kx3n6m 266 4 this this DT cord-347946-i6kx3n6m 266 5 removes remove VBZ cord-347946-i6kx3n6m 266 6 pathogen pathogen NN cord-347946-i6kx3n6m 266 7 - - HYPH cord-347946-i6kx3n6m 266 8 host host NN cord-347946-i6kx3n6m 266 9 defense defense NN cord-347946-i6kx3n6m 266 10 as as IN cord-347946-i6kx3n6m 266 11 an an DT cord-347946-i6kx3n6m 266 12 explanation explanation NN cord-347946-i6kx3n6m 266 13 for for IN cord-347946-i6kx3n6m 266 14 the the DT cord-347946-i6kx3n6m 266 15 conundrum conundrum NN cord-347946-i6kx3n6m 266 16 of of IN cord-347946-i6kx3n6m 266 17 why why WRB cord-347946-i6kx3n6m 266 18 genes gene NNS cord-347946-i6kx3n6m 266 19 that that WDT cord-347946-i6kx3n6m 266 20 contribute contribute VBP cord-347946-i6kx3n6m 266 21 to to IN cord-347946-i6kx3n6m 266 22 MDD MDD NNP cord-347946-i6kx3n6m 266 23 have have VBP cord-347946-i6kx3n6m 266 24 been be VBN cord-347946-i6kx3n6m 266 25 retained retain VBN cord-347946-i6kx3n6m 266 26 across across IN cord-347946-i6kx3n6m 266 27 hominid hominid JJ cord-347946-i6kx3n6m 266 28 evolution evolution NN cord-347946-i6kx3n6m 266 29 . . . cord-347946-i6kx3n6m 267 1 Or or CC cord-347946-i6kx3n6m 267 2 it -PRON- PRP cord-347946-i6kx3n6m 267 3 may may MD cord-347946-i6kx3n6m 267 4 be be VB cord-347946-i6kx3n6m 267 5 that that IN cord-347946-i6kx3n6m 267 6 by by IN cord-347946-i6kx3n6m 267 7 inducing induce VBG cord-347946-i6kx3n6m 267 8 social social JJ cord-347946-i6kx3n6m 267 9 withdrawal withdrawal NN cord-347946-i6kx3n6m 267 10 , , , cord-347946-i6kx3n6m 267 11 depression depression NN cord-347946-i6kx3n6m 267 12 provides provide VBZ cord-347946-i6kx3n6m 267 13 an an DT cord-347946-i6kx3n6m 267 14 adaptive adaptive JJ cord-347946-i6kx3n6m 267 15 advantage advantage NN cord-347946-i6kx3n6m 267 16 for for IN cord-347946-i6kx3n6m 267 17 individuals individual NNS cord-347946-i6kx3n6m 267 18 at at IN cord-347946-i6kx3n6m 267 19 increased increase VBN cord-347946-i6kx3n6m 267 20 risk risk NN cord-347946-i6kx3n6m 267 21 of of IN cord-347946-i6kx3n6m 267 22 infection infection NN cord-347946-i6kx3n6m 267 23 as as IN cord-347946-i6kx3n6m 267 24 a a DT cord-347946-i6kx3n6m 267 25 result result NN cord-347946-i6kx3n6m 267 26 of of IN cord-347946-i6kx3n6m 267 27 immune immune JJ cord-347946-i6kx3n6m 267 28 functioning functioning NN cord-347946-i6kx3n6m 267 29 that that IN cord-347946-i6kx3n6m 267 30 for for IN cord-347946-i6kx3n6m 267 31 one one CD cord-347946-i6kx3n6m 267 32 reason reason NN cord-347946-i6kx3n6m 267 33 or or CC cord-347946-i6kx3n6m 267 34 other other JJ cord-347946-i6kx3n6m 267 35 is be VBZ cord-347946-i6kx3n6m 267 36 sub sub NN cord-347946-i6kx3n6m 267 37 - - JJ cord-347946-i6kx3n6m 267 38 optimal optimal JJ cord-347946-i6kx3n6m 267 39 . . . cord-347946-i6kx3n6m 268 1 This this DT cord-347946-i6kx3n6m 268 2 is be VBZ cord-347946-i6kx3n6m 268 3 the the DT cord-347946-i6kx3n6m 268 4 position position NN cord-347946-i6kx3n6m 268 5 taken take VBN cord-347946-i6kx3n6m 268 6 by by IN cord-347946-i6kx3n6m 268 7 Kinney Kinney NNP cord-347946-i6kx3n6m 268 8 and and CC cord-347946-i6kx3n6m 268 9 Tanaka Tanaka NNP cord-347946-i6kx3n6m 268 10 ( ( -LRB- cord-347946-i6kx3n6m 268 11 2009 2009 CD cord-347946-i6kx3n6m 268 12 ) ) -RRB- cord-347946-i6kx3n6m 268 13 in in IN cord-347946-i6kx3n6m 268 14 proposing propose VBG cord-347946-i6kx3n6m 268 15 that that IN cord-347946-i6kx3n6m 268 16 depression depression NN cord-347946-i6kx3n6m 268 17 evolved evolve VBD cord-347946-i6kx3n6m 268 18 as as IN cord-347946-i6kx3n6m 268 19 an an DT cord-347946-i6kx3n6m 268 20 adaptive adaptive JJ cord-347946-i6kx3n6m 268 21 response response NN cord-347946-i6kx3n6m 268 22 to to TO cord-347946-i6kx3n6m 268 23 cope cope VB cord-347946-i6kx3n6m 268 24 with with IN cord-347946-i6kx3n6m 268 25 pathogens pathogen NNS cord-347946-i6kx3n6m 269 1 ( ( -LRB- cord-347946-i6kx3n6m 269 2 Anders Anders NNP cord-347946-i6kx3n6m 269 3 et et NNP cord-347946-i6kx3n6m 269 4 al al NNP cord-347946-i6kx3n6m 269 5 , , , cord-347946-i6kx3n6m 269 6 2013 2013 CD cord-347946-i6kx3n6m 269 7 ) ) -RRB- cord-347946-i6kx3n6m 269 8 . . . cord-347946-i6kx3n6m 270 1 In in IN cord-347946-i6kx3n6m 270 2 contradistinction contradistinction NN cord-347946-i6kx3n6m 270 3 , , , cord-347946-i6kx3n6m 270 4 PATHOS pathos NN cord-347946-i6kx3n6m 270 5 - - HYPH cord-347946-i6kx3n6m 270 6 D D NNP cord-347946-i6kx3n6m 270 7 suggests suggest VBZ cord-347946-i6kx3n6m 270 8 that that IN cord-347946-i6kx3n6m 270 9 - - : cord-347946-i6kx3n6m 270 10 whatever whatever WDT cord-347946-i6kx3n6m 270 11 its -PRON- PRP$ cord-347946-i6kx3n6m 270 12 costs cost NNS cord-347946-i6kx3n6m 270 13 in in IN cord-347946-i6kx3n6m 270 14 relation relation NN cord-347946-i6kx3n6m 270 15 to to IN cord-347946-i6kx3n6m 270 16 specific specific JJ cord-347946-i6kx3n6m 270 17 pathogens pathogen NNS cord-347946-i6kx3n6m 270 18 - - : cord-347946-i6kx3n6m 270 19 depression depression NN cord-347946-i6kx3n6m 270 20 was be VBD cord-347946-i6kx3n6m 270 21 not not RB cord-347946-i6kx3n6m 270 22 primarily primarily RB cord-347946-i6kx3n6m 270 23 a a DT cord-347946-i6kx3n6m 270 24 compensation compensation NN cord-347946-i6kx3n6m 270 25 for for IN cord-347946-i6kx3n6m 270 26 immune immune JJ cord-347946-i6kx3n6m 270 27 inadequacy inadequacy NN cord-347946-i6kx3n6m 270 28 , , , cord-347946-i6kx3n6m 270 29 but but CC cord-347946-i6kx3n6m 270 30 rather rather RB cord-347946-i6kx3n6m 270 31 enhanced enhanced JJ cord-347946-i6kx3n6m 270 32 overall overall JJ cord-347946-i6kx3n6m 270 33 survival survival NN cord-347946-i6kx3n6m 270 34 in in IN cord-347946-i6kx3n6m 270 35 the the DT cord-347946-i6kx3n6m 270 36 EEA EEA NNP cord-347946-i6kx3n6m 270 37 via via IN cord-347946-i6kx3n6m 270 38 its -PRON- PRP$ cord-347946-i6kx3n6m 270 39 association association NN cord-347946-i6kx3n6m 270 40 with with IN cord-347946-i6kx3n6m 270 41 physiological physiological JJ cord-347946-i6kx3n6m 270 42 and and CC cord-347946-i6kx3n6m 270 43 behavioral behavioral JJ cord-347946-i6kx3n6m 270 44 changes change NNS cord-347946-i6kx3n6m 270 45 that that WDT cord-347946-i6kx3n6m 270 46 reduced reduce VBD cord-347946-i6kx3n6m 270 47 the the DT cord-347946-i6kx3n6m 270 48 impact impact NN cord-347946-i6kx3n6m 270 49 of of IN cord-347946-i6kx3n6m 270 50 infectious infectious JJ cord-347946-i6kx3n6m 270 51 agents agent NNS cord-347946-i6kx3n6m 270 52 on on IN cord-347946-i6kx3n6m 270 53 reproductive reproductive JJ cord-347946-i6kx3n6m 270 54 success success NN cord-347946-i6kx3n6m 270 55 . . . cord-347946-i6kx3n6m 271 1 Said say VBD cord-347946-i6kx3n6m 271 2 differently differently RB cord-347946-i6kx3n6m 271 3 , , , cord-347946-i6kx3n6m 271 4 in in IN cord-347946-i6kx3n6m 271 5 conditions condition NNS cord-347946-i6kx3n6m 271 6 characterized characterize VBN cord-347946-i6kx3n6m 271 7 by by IN cord-347946-i6kx3n6m 271 8 a a DT cord-347946-i6kx3n6m 271 9 heightened heightened JJ cord-347946-i6kx3n6m 271 10 risk risk NN cord-347946-i6kx3n6m 271 11 for for IN cord-347946-i6kx3n6m 271 12 infectious infectious JJ cord-347946-i6kx3n6m 271 13 mortality mortality NN cord-347946-i6kx3n6m 271 14 , , , cord-347946-i6kx3n6m 271 15 such such JJ cord-347946-i6kx3n6m 271 16 as as IN cord-347946-i6kx3n6m 271 17 occur occur VBP cord-347946-i6kx3n6m 271 18 during during IN cord-347946-i6kx3n6m 271 19 active active JJ cord-347946-i6kx3n6m 271 20 infection infection NN cord-347946-i6kx3n6m 271 21 or or CC cord-347946-i6kx3n6m 271 22 when when WRB cord-347946-i6kx3n6m 271 23 environmental environmental JJ cord-347946-i6kx3n6m 271 24 adversity adversity NN cord-347946-i6kx3n6m 271 25 signals signal VBZ cord-347946-i6kx3n6m 271 26 an an DT cord-347946-i6kx3n6m 271 27 increased increase VBN cord-347946-i6kx3n6m 271 28 risk risk NN cord-347946-i6kx3n6m 271 29 for for IN cord-347946-i6kx3n6m 271 30 wounding wounding NN cord-347946-i6kx3n6m 271 31 or or CC cord-347946-i6kx3n6m 271 32 other other JJ cord-347946-i6kx3n6m 271 33 processes process NNS cord-347946-i6kx3n6m 271 34 that that WDT cord-347946-i6kx3n6m 271 35 increase increase VBP cord-347946-i6kx3n6m 271 36 the the DT cord-347946-i6kx3n6m 271 37 risk risk NN cord-347946-i6kx3n6m 271 38 of of IN cord-347946-i6kx3n6m 271 39 infection infection NN cord-347946-i6kx3n6m 271 40 ( ( -LRB- cord-347946-i6kx3n6m 271 41 ie ie FW cord-347946-i6kx3n6m 271 42 , , , cord-347946-i6kx3n6m 271 43 starvation starvation NN cord-347946-i6kx3n6m 271 44 secondary secondary JJ cord-347946-i6kx3n6m 271 45 to to IN cord-347946-i6kx3n6m 271 46 ostracism ostracism NN cord-347946-i6kx3n6m 271 47 ) ) -RRB- cord-347946-i6kx3n6m 271 48 , , , cord-347946-i6kx3n6m 271 49 the the DT cord-347946-i6kx3n6m 271 50 generalized generalized JJ cord-347946-i6kx3n6m 271 51 innate innate JJ cord-347946-i6kx3n6m 271 52 immune immune JJ cord-347946-i6kx3n6m 271 53 activation activation NN cord-347946-i6kx3n6m 271 54 and and CC cord-347946-i6kx3n6m 271 55 symptoms symptom NNS cord-347946-i6kx3n6m 271 56 associated associate VBN cord-347946-i6kx3n6m 271 57 with with IN cord-347946-i6kx3n6m 271 58 depression depression NN cord-347946-i6kx3n6m 271 59 provided provide VBD cord-347946-i6kx3n6m 271 60 a a DT cord-347946-i6kx3n6m 271 61 net net JJ cord-347946-i6kx3n6m 271 62 survival survival NN cord-347946-i6kx3n6m 271 63 benefit benefit NN cord-347946-i6kx3n6m 271 64 , , , cord-347946-i6kx3n6m 271 65 whatever whatever WDT cord-347946-i6kx3n6m 271 66 their -PRON- PRP$ cord-347946-i6kx3n6m 271 67 other other JJ cord-347946-i6kx3n6m 271 68 costs cost NNS cord-347946-i6kx3n6m 271 69 in in IN cord-347946-i6kx3n6m 271 70 terms term NNS cord-347946-i6kx3n6m 271 71 of of IN cord-347946-i6kx3n6m 271 72 immune immune JJ cord-347946-i6kx3n6m 271 73 or or CC cord-347946-i6kx3n6m 271 74 social social JJ cord-347946-i6kx3n6m 271 75 trade trade NN cord-347946-i6kx3n6m 271 76 - - HYPH cord-347946-i6kx3n6m 271 77 offs off NNS cord-347946-i6kx3n6m 271 78 . . . cord-347946-i6kx3n6m 272 1 Importantly importantly RB cord-347946-i6kx3n6m 272 2 , , , cord-347946-i6kx3n6m 272 3 this this DT cord-347946-i6kx3n6m 272 4 perspective perspective NN cord-347946-i6kx3n6m 272 5 does do VBZ cord-347946-i6kx3n6m 272 6 not not RB cord-347946-i6kx3n6m 272 7 require require VB cord-347946-i6kx3n6m 272 8 that that IN cord-347946-i6kx3n6m 272 9 depression depression NN cord-347946-i6kx3n6m 272 10 be be VB cord-347946-i6kx3n6m 272 11 the the DT cord-347946-i6kx3n6m 272 12 only only JJ cord-347946-i6kx3n6m 272 13 way way NN cord-347946-i6kx3n6m 272 14 for for IN cord-347946-i6kx3n6m 272 15 humans human NNS cord-347946-i6kx3n6m 272 16 to to TO cord-347946-i6kx3n6m 272 17 adaptively adaptively RB cord-347946-i6kx3n6m 272 18 cope cope VB cord-347946-i6kx3n6m 272 19 with with IN cord-347946-i6kx3n6m 272 20 infectious infectious JJ cord-347946-i6kx3n6m 272 21 risk risk NN cord-347946-i6kx3n6m 272 22 only only RB cord-347946-i6kx3n6m 272 23 that that IN cord-347946-i6kx3n6m 272 24 it -PRON- PRP cord-347946-i6kx3n6m 272 25 was be VBD cord-347946-i6kx3n6m 272 26 adaptive adaptive JJ cord-347946-i6kx3n6m 272 27 enough enough RB cord-347946-i6kx3n6m 272 28 for for IN cord-347946-i6kx3n6m 272 29 its -PRON- PRP$ cord-347946-i6kx3n6m 272 30 genetic genetic JJ cord-347946-i6kx3n6m 272 31 underpinnings underpinning NNS cord-347946-i6kx3n6m 272 32 to to TO cord-347946-i6kx3n6m 272 33 be be VB cord-347946-i6kx3n6m 272 34 retained retain VBN cord-347946-i6kx3n6m 272 35 in in IN cord-347946-i6kx3n6m 272 36 the the DT cord-347946-i6kx3n6m 272 37 human human JJ cord-347946-i6kx3n6m 272 38 genome genome NN cord-347946-i6kx3n6m 272 39 at at IN cord-347946-i6kx3n6m 272 40 a a DT cord-347946-i6kx3n6m 272 41 level level NN cord-347946-i6kx3n6m 272 42 significant significant JJ cord-347946-i6kx3n6m 272 43 enough enough RB cord-347946-i6kx3n6m 272 44 for for IN cord-347946-i6kx3n6m 272 45 MDD MDD NNP cord-347946-i6kx3n6m 272 46 to to TO cord-347946-i6kx3n6m 272 47 be be VB cord-347946-i6kx3n6m 272 48 with with IN cord-347946-i6kx3n6m 272 49 us -PRON- PRP cord-347946-i6kx3n6m 272 50 today today NN cord-347946-i6kx3n6m 272 51 . . . cord-347946-i6kx3n6m 273 1 From from IN cord-347946-i6kx3n6m 273 2 a a DT cord-347946-i6kx3n6m 273 3 PATHOS pathos NN cord-347946-i6kx3n6m 273 4 - - HYPH cord-347946-i6kx3n6m 273 5 D d JJ cord-347946-i6kx3n6m 273 6 perspective perspective NN cord-347946-i6kx3n6m 273 7 , , , cord-347946-i6kx3n6m 273 8 MDD MDD NNP cord-347946-i6kx3n6m 273 9 in in IN cord-347946-i6kx3n6m 273 10 response response NN cord-347946-i6kx3n6m 273 11 to to IN cord-347946-i6kx3n6m 273 12 infection infection NN cord-347946-i6kx3n6m 273 13 or or CC cord-347946-i6kx3n6m 273 14 tissue tissue NN cord-347946-i6kx3n6m 273 15 trauma trauma NN cord-347946-i6kx3n6m 273 16 provides provide VBZ cord-347946-i6kx3n6m 273 17 the the DT cord-347946-i6kx3n6m 273 18 same same JJ cord-347946-i6kx3n6m 273 19 types type NNS cord-347946-i6kx3n6m 273 20 of of IN cord-347946-i6kx3n6m 273 21 survival survival NN cord-347946-i6kx3n6m 273 22 benefits benefit NNS cord-347946-i6kx3n6m 273 23 as as IN cord-347946-i6kx3n6m 273 24 does do VBZ cord-347946-i6kx3n6m 273 25 sickness sickness NN cord-347946-i6kx3n6m 273 26 behavior behavior NN cord-347946-i6kx3n6m 273 27 . . . cord-347946-i6kx3n6m 274 1 In in IN cord-347946-i6kx3n6m 274 2 response response NN cord-347946-i6kx3n6m 274 3 to to IN cord-347946-i6kx3n6m 274 4 stress stress NN cord-347946-i6kx3n6m 274 5 , , , cord-347946-i6kx3n6m 274 6 depression depression NN cord-347946-i6kx3n6m 274 7 can can MD cord-347946-i6kx3n6m 274 8 be be VB cord-347946-i6kx3n6m 274 9 seen see VBN cord-347946-i6kx3n6m 274 10 as as IN cord-347946-i6kx3n6m 274 11 proactive proactive JJ cord-347946-i6kx3n6m 274 12 physiological physiological JJ cord-347946-i6kx3n6m 274 13 / / SYM cord-347946-i6kx3n6m 274 14 behavioral behavioral JJ cord-347946-i6kx3n6m 274 15 sickness sickness NN cord-347946-i6kx3n6m 274 16 behavior behavior NN cord-347946-i6kx3n6m 274 17 - - : cord-347946-i6kx3n6m 274 18 a a DT cord-347946-i6kx3n6m 274 19 type type NN cord-347946-i6kx3n6m 274 20 of of IN cord-347946-i6kx3n6m 274 21 ' ' '' cord-347946-i6kx3n6m 274 22 just just RB cord-347946-i6kx3n6m 274 23 in in IN cord-347946-i6kx3n6m 274 24 case case NN cord-347946-i6kx3n6m 274 25 ' ' '' cord-347946-i6kx3n6m 274 26 condition condition NN cord-347946-i6kx3n6m 274 27 that that WDT cord-347946-i6kx3n6m 274 28 keeps keep VBZ cord-347946-i6kx3n6m 274 29 an an DT cord-347946-i6kx3n6m 274 30 individual individual NN cord-347946-i6kx3n6m 274 31 in in IN cord-347946-i6kx3n6m 274 32 a a DT cord-347946-i6kx3n6m 274 33 state state NN cord-347946-i6kx3n6m 274 34 of of IN cord-347946-i6kx3n6m 274 35 pathogen pathogen NN cord-347946-i6kx3n6m 274 36 defense defense NN cord-347946-i6kx3n6m 274 37 readiness readiness NN cord-347946-i6kx3n6m 274 38 . . . cord-347946-i6kx3n6m 275 1 Proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 275 2 cytokine cytokine NN cord-347946-i6kx3n6m 275 3 activation activation NN cord-347946-i6kx3n6m 275 4 in in IN cord-347946-i6kx3n6m 275 5 response response NN cord-347946-i6kx3n6m 275 6 to to IN cord-347946-i6kx3n6m 275 7 either either CC cord-347946-i6kx3n6m 275 8 infection infection NN cord-347946-i6kx3n6m 275 9 or or CC cord-347946-i6kx3n6m 275 10 stress stress NN cord-347946-i6kx3n6m 275 11 induces induce VBZ cord-347946-i6kx3n6m 275 12 a a DT cord-347946-i6kx3n6m 275 13 behavioral behavioral JJ cord-347946-i6kx3n6m 275 14 state state NN cord-347946-i6kx3n6m 275 15 of of IN cord-347946-i6kx3n6m 275 16 conservationwithdrawal conservationwithdrawal NNP cord-347946-i6kx3n6m 275 17 ( ( -LRB- cord-347946-i6kx3n6m 275 18 Engel Engel NNP cord-347946-i6kx3n6m 275 19 and and CC cord-347946-i6kx3n6m 275 20 Schmale Schmale NNP cord-347946-i6kx3n6m 275 21 , , , cord-347946-i6kx3n6m 275 22 1972 1972 CD cord-347946-i6kx3n6m 276 1 ; ; : cord-347946-i6kx3n6m 276 2 Eisenberger Eisenberger NNP cord-347946-i6kx3n6m 276 3 et et FW cord-347946-i6kx3n6m 276 4 al al NNP cord-347946-i6kx3n6m 276 5 , , , cord-347946-i6kx3n6m 276 6 2010b 2010b CD cord-347946-i6kx3n6m 276 7 ; ; : cord-347946-i6kx3n6m 276 8 Hannestad Hannestad NNP cord-347946-i6kx3n6m 276 9 et et NNP cord-347946-i6kx3n6m 276 10 al al NNP cord-347946-i6kx3n6m 276 11 , , , cord-347946-i6kx3n6m 276 12 2011 2011 CD cord-347946-i6kx3n6m 276 13 ) ) -RRB- cord-347946-i6kx3n6m 276 14 characterized characterize VBN cord-347946-i6kx3n6m 276 15 by by IN cord-347946-i6kx3n6m 276 16 depressed depressed JJ cord-347946-i6kx3n6m 276 17 mood mood NN cord-347946-i6kx3n6m 276 18 , , , cord-347946-i6kx3n6m 276 19 anhedonia anhedonia NN cord-347946-i6kx3n6m 276 20 , , , cord-347946-i6kx3n6m 276 21 psychomotor psychomotor JJ cord-347946-i6kx3n6m 276 22 retardation retardation NN cord-347946-i6kx3n6m 276 23 , , , cord-347946-i6kx3n6m 276 24 fatigue fatigue NN cord-347946-i6kx3n6m 276 25 , , , cord-347946-i6kx3n6m 276 26 social social JJ cord-347946-i6kx3n6m 276 27 avoidance avoidance NN cord-347946-i6kx3n6m 276 28 , , , cord-347946-i6kx3n6m 276 29 and and CC cord-347946-i6kx3n6m 276 30 anorexia anorexia NN cord-347946-i6kx3n6m 276 31 ( ( -LRB- cord-347946-i6kx3n6m 276 32 Capuron Capuron NNP cord-347946-i6kx3n6m 276 33 et et NNP cord-347946-i6kx3n6m 276 34 al al NNP cord-347946-i6kx3n6m 276 35 , , , cord-347946-i6kx3n6m 276 36 2002 2002 CD cord-347946-i6kx3n6m 276 37 ; ; : cord-347946-i6kx3n6m 276 38 Dantzer Dantzer NNP cord-347946-i6kx3n6m 276 39 et et FW cord-347946-i6kx3n6m 276 40 al al NNP cord-347946-i6kx3n6m 276 41 , , , cord-347946-i6kx3n6m 276 42 2008b 2008b CD cord-347946-i6kx3n6m 276 43 ; ; : cord-347946-i6kx3n6m 276 44 Majer Majer NNP cord-347946-i6kx3n6m 276 45 et et NNP cord-347946-i6kx3n6m 276 46 al al NNP cord-347946-i6kx3n6m 276 47 , , , cord-347946-i6kx3n6m 276 48 2008 2008 CD cord-347946-i6kx3n6m 276 49 ; ; : cord-347946-i6kx3n6m 276 50 Irwin Irwin NNP cord-347946-i6kx3n6m 276 51 and and CC cord-347946-i6kx3n6m 276 52 Cole Cole NNP cord-347946-i6kx3n6m 276 53 , , , cord-347946-i6kx3n6m 276 54 2011 2011 CD cord-347946-i6kx3n6m 276 55 ) ) -RRB- cord-347946-i6kx3n6m 276 56 . . . cord-347946-i6kx3n6m 277 1 This this DT cord-347946-i6kx3n6m 277 2 state state NN cord-347946-i6kx3n6m 277 3 is be VBZ cord-347946-i6kx3n6m 277 4 an an DT cord-347946-i6kx3n6m 277 5 integral integral JJ cord-347946-i6kx3n6m 277 6 component component NN cord-347946-i6kx3n6m 277 7 of of IN cord-347946-i6kx3n6m 277 8 depressive depressive JJ cord-347946-i6kx3n6m 277 9 disorders disorder NNS cord-347946-i6kx3n6m 277 10 and and CC cord-347946-i6kx3n6m 277 11 has have VBZ cord-347946-i6kx3n6m 277 12 been be VBN cord-347946-i6kx3n6m 277 13 widely widely RB cord-347946-i6kx3n6m 277 14 considered consider VBN cord-347946-i6kx3n6m 277 15 to to TO cord-347946-i6kx3n6m 277 16 develop develop VB cord-347946-i6kx3n6m 277 17 in in IN cord-347946-i6kx3n6m 277 18 the the DT cord-347946-i6kx3n6m 277 19 context context NN cord-347946-i6kx3n6m 277 20 of of IN cord-347946-i6kx3n6m 277 21 infection infection NN cord-347946-i6kx3n6m 277 22 and/ and/ CD cord-347946-i6kx3n6m 277 23 or or CC cord-347946-i6kx3n6m 277 24 tissue tissue NN cord-347946-i6kx3n6m 277 25 injury injury NN cord-347946-i6kx3n6m 277 26 as as IN cord-347946-i6kx3n6m 277 27 a a DT cord-347946-i6kx3n6m 277 28 means means NN cord-347946-i6kx3n6m 277 29 of of IN cord-347946-i6kx3n6m 277 30 marshalling marshal VBG cord-347946-i6kx3n6m 277 31 limited limited JJ cord-347946-i6kx3n6m 277 32 metabolic metabolic JJ cord-347946-i6kx3n6m 277 33 resources resource NNS cord-347946-i6kx3n6m 277 34 for for IN cord-347946-i6kx3n6m 277 35 the the DT cord-347946-i6kx3n6m 277 36 expensive expensive JJ cord-347946-i6kx3n6m 277 37 tasks task NNS cord-347946-i6kx3n6m 277 38 of of IN cord-347946-i6kx3n6m 277 39 immune immune JJ cord-347946-i6kx3n6m 277 40 activation activation NN cord-347946-i6kx3n6m 277 41 , , , cord-347946-i6kx3n6m 277 42 fever fever NN cord-347946-i6kx3n6m 277 43 generation generation NN cord-347946-i6kx3n6m 277 44 and and CC cord-347946-i6kx3n6m 277 45 tissue tissue NN cord-347946-i6kx3n6m 277 46 repair repair NN cord-347946-i6kx3n6m 277 47 ( ( -LRB- cord-347946-i6kx3n6m 277 48 Hanff Hanff NNP cord-347946-i6kx3n6m 277 49 et et NNP cord-347946-i6kx3n6m 277 50 al al NNP cord-347946-i6kx3n6m 277 51 , , , cord-347946-i6kx3n6m 277 52 2010 2010 CD cord-347946-i6kx3n6m 277 53 ) ) -RRB- cord-347946-i6kx3n6m 277 54 . . . cord-347946-i6kx3n6m 278 1 In in IN cord-347946-i6kx3n6m 278 2 addition addition NN cord-347946-i6kx3n6m 278 3 to to IN cord-347946-i6kx3n6m 278 4 energy energy NN cord-347946-i6kx3n6m 278 5 allocation allocation NN cord-347946-i6kx3n6m 278 6 , , , cord-347946-i6kx3n6m 278 7 conservation conservation NN cord-347946-i6kx3n6m 278 8 - - HYPH cord-347946-i6kx3n6m 278 9 withdrawal withdrawal NN cord-347946-i6kx3n6m 278 10 symptoms symptom NNS cord-347946-i6kx3n6m 278 11 may may MD cord-347946-i6kx3n6m 278 12 have have VB cord-347946-i6kx3n6m 278 13 also also RB cord-347946-i6kx3n6m 278 14 proved prove VBN cord-347946-i6kx3n6m 278 15 adaptive adaptive JJ cord-347946-i6kx3n6m 278 16 by by IN cord-347946-i6kx3n6m 278 17 reducing reduce VBG cord-347946-i6kx3n6m 278 18 interpersonal interpersonal JJ cord-347946-i6kx3n6m 278 19 contact contact NN cord-347946-i6kx3n6m 278 20 and and CC cord-347946-i6kx3n6m 278 21 thereby thereby RB cord-347946-i6kx3n6m 278 22 limiting limit VBG cord-347946-i6kx3n6m 278 23 infectious infectious JJ cord-347946-i6kx3n6m 278 24 exposure exposure NN cord-347946-i6kx3n6m 278 25 ( ( -LRB- cord-347946-i6kx3n6m 278 26 Kinney Kinney NNP cord-347946-i6kx3n6m 278 27 and and CC cord-347946-i6kx3n6m 278 28 Tanaka Tanaka NNP cord-347946-i6kx3n6m 278 29 , , , cord-347946-i6kx3n6m 278 30 2009 2009 CD cord-347946-i6kx3n6m 278 31 ) ) -RRB- cord-347946-i6kx3n6m 278 32 . . . cord-347946-i6kx3n6m 279 1 In in IN cord-347946-i6kx3n6m 279 2 the the DT cord-347946-i6kx3n6m 279 3 paradigm paradigm NN cord-347946-i6kx3n6m 279 4 proposed propose VBN cord-347946-i6kx3n6m 279 5 by by IN cord-347946-i6kx3n6m 279 6 Kinney Kinney NNP cord-347946-i6kx3n6m 279 7 and and CC cord-347946-i6kx3n6m 279 8 Tanaka Tanaka NNP cord-347946-i6kx3n6m 279 9 ( ( -LRB- cord-347946-i6kx3n6m 279 10 2009 2009 CD cord-347946-i6kx3n6m 279 11 ) ) -RRB- cord-347946-i6kx3n6m 279 12 this this DT cord-347946-i6kx3n6m 279 13 is be VBZ cord-347946-i6kx3n6m 279 14 seen see VBN cord-347946-i6kx3n6m 279 15 as as IN cord-347946-i6kx3n6m 279 16 an an DT cord-347946-i6kx3n6m 279 17 evolved evolve VBN cord-347946-i6kx3n6m 279 18 compensatory compensatory JJ cord-347946-i6kx3n6m 279 19 mechanism mechanism NN cord-347946-i6kx3n6m 279 20 to to TO cord-347946-i6kx3n6m 279 21 cope cope VB cord-347946-i6kx3n6m 279 22 with with IN cord-347946-i6kx3n6m 279 23 immunodeficiency immunodeficiency NN cord-347946-i6kx3n6m 279 24 . . . cord-347946-i6kx3n6m 280 1 However however RB cord-347946-i6kx3n6m 280 2 , , , cord-347946-i6kx3n6m 280 3 it -PRON- PRP cord-347946-i6kx3n6m 280 4 is be VBZ cord-347946-i6kx3n6m 280 5 equally equally RB cord-347946-i6kx3n6m 280 6 possible possible JJ cord-347946-i6kx3n6m 280 7 that that IN cord-347946-i6kx3n6m 280 8 the the DT cord-347946-i6kx3n6m 280 9 infectionavoidance infectionavoidance NN cord-347946-i6kx3n6m 280 10 benefits benefit NNS cord-347946-i6kx3n6m 280 11 of of IN cord-347946-i6kx3n6m 280 12 social social JJ cord-347946-i6kx3n6m 280 13 withdrawal withdrawal NN cord-347946-i6kx3n6m 280 14 evolved evolve VBD cord-347946-i6kx3n6m 280 15 as as IN cord-347946-i6kx3n6m 280 16 a a DT cord-347946-i6kx3n6m 280 17 complement complement NN cord-347946-i6kx3n6m 280 18 to to IN cord-347946-i6kx3n6m 280 19 its -PRON- PRP$ cord-347946-i6kx3n6m 280 20 metabolically metabolically RB cord-347946-i6kx3n6m 280 21 valuable valuable JJ cord-347946-i6kx3n6m 280 22 infection infection NN cord-347946-i6kx3n6m 280 23 - - HYPH cord-347946-i6kx3n6m 280 24 fighting fight VBG cord-347946-i6kx3n6m 280 25 benefits benefit NNS cord-347946-i6kx3n6m 280 26 . . . cord-347946-i6kx3n6m 281 1 Indeed indeed RB cord-347946-i6kx3n6m 281 2 , , , cord-347946-i6kx3n6m 281 3 the the DT cord-347946-i6kx3n6m 281 4 more more JJR cord-347946-i6kx3n6m 281 5 survival survival NN cord-347946-i6kx3n6m 281 6 and and CC cord-347946-i6kx3n6m 281 7 reproductive reproductive JJ cord-347946-i6kx3n6m 281 8 benefits benefit NNS cord-347946-i6kx3n6m 281 9 accrue accrue VBN cord-347946-i6kx3n6m 281 10 for for IN cord-347946-i6kx3n6m 281 11 any any DT cord-347946-i6kx3n6m 281 12 one one CD cord-347946-i6kx3n6m 281 13 trait trait NN cord-347946-i6kx3n6m 281 14 the the DT cord-347946-i6kx3n6m 281 15 more more RBR cord-347946-i6kx3n6m 281 16 likely likely JJ cord-347946-i6kx3n6m 281 17 its -PRON- PRP$ cord-347946-i6kx3n6m 281 18 genetic genetic JJ cord-347946-i6kx3n6m 281 19 antecedents antecedent NNS cord-347946-i6kx3n6m 281 20 are be VBP cord-347946-i6kx3n6m 281 21 to to TO cord-347946-i6kx3n6m 281 22 be be VB cord-347946-i6kx3n6m 281 23 retained retain VBN cord-347946-i6kx3n6m 281 24 and and CC cord-347946-i6kx3n6m 281 25 to to TO cord-347946-i6kx3n6m 281 26 spread spread VB cord-347946-i6kx3n6m 281 27 in in IN cord-347946-i6kx3n6m 281 28 the the DT cord-347946-i6kx3n6m 281 29 population population NN cord-347946-i6kx3n6m 281 30 . . . cord-347946-i6kx3n6m 282 1 Because because IN cord-347946-i6kx3n6m 282 2 humans human NNS cord-347946-i6kx3n6m 282 3 in in IN cord-347946-i6kx3n6m 282 4 the the DT cord-347946-i6kx3n6m 282 5 EEA EEA NNP cord-347946-i6kx3n6m 282 6 lived live VBD cord-347946-i6kx3n6m 282 7 in in IN cord-347946-i6kx3n6m 282 8 small small JJ cord-347946-i6kx3n6m 282 9 coalitional coalitional JJ cord-347946-i6kx3n6m 282 10 groups group NNS cord-347946-i6kx3n6m 282 11 of of IN cord-347946-i6kx3n6m 282 12 genetically genetically RB cord-347946-i6kx3n6m 282 13 related relate VBN cord-347946-i6kx3n6m 282 14 individuals individual NNS cord-347946-i6kx3n6m 282 15 , , , cord-347946-i6kx3n6m 282 16 the the DT cord-347946-i6kx3n6m 282 17 logic logic NN cord-347946-i6kx3n6m 282 18 of of IN cord-347946-i6kx3n6m 282 19 inclusive inclusive JJ cord-347946-i6kx3n6m 282 20 fitness fitness NN cord-347946-i6kx3n6m 282 21 suggests suggest VBZ cord-347946-i6kx3n6m 282 22 that that IN cord-347946-i6kx3n6m 282 23 social social JJ cord-347946-i6kx3n6m 282 24 withdrawal withdrawal NN cord-347946-i6kx3n6m 282 25 might may MD cord-347946-i6kx3n6m 282 26 have have VB cord-347946-i6kx3n6m 282 27 been be VBN cord-347946-i6kx3n6m 282 28 adaptive adaptive JJ cord-347946-i6kx3n6m 282 29 for for IN cord-347946-i6kx3n6m 282 30 an an DT cord-347946-i6kx3n6m 282 31 individual individual NN cord-347946-i6kx3n6m 282 32 's 's POS cord-347946-i6kx3n6m 282 33 genes gene NNS cord-347946-i6kx3n6m 282 34 by by IN cord-347946-i6kx3n6m 282 35 reducing reduce VBG cord-347946-i6kx3n6m 282 36 the the DT cord-347946-i6kx3n6m 282 37 risk risk NN cord-347946-i6kx3n6m 282 38 of of IN cord-347946-i6kx3n6m 282 39 infection infection NN cord-347946-i6kx3n6m 282 40 in in IN cord-347946-i6kx3n6m 282 41 kin kin NN cord-347946-i6kx3n6m 282 42 , , , cord-347946-i6kx3n6m 282 43 even even RB cord-347946-i6kx3n6m 282 44 if if IN cord-347946-i6kx3n6m 282 45 such such JJ cord-347946-i6kx3n6m 282 46 withdrawal withdrawal NN cord-347946-i6kx3n6m 282 47 limited limit VBD cord-347946-i6kx3n6m 282 48 the the DT cord-347946-i6kx3n6m 282 49 provision provision NN cord-347946-i6kx3n6m 282 50 of of IN cord-347946-i6kx3n6m 282 51 much much JJ cord-347946-i6kx3n6m 282 52 needed need VBN cord-347946-i6kx3n6m 282 53 care care NN cord-347946-i6kx3n6m 282 54 from from IN cord-347946-i6kx3n6m 282 55 others other NNS cord-347946-i6kx3n6m 282 56 and and CC cord-347946-i6kx3n6m 282 57 thus thus RB cord-347946-i6kx3n6m 282 58 reduced reduce VBN cord-347946-i6kx3n6m 282 59 individual individual JJ cord-347946-i6kx3n6m 282 60 survival survival NN cord-347946-i6kx3n6m 282 61 ( ( -LRB- cord-347946-i6kx3n6m 282 62 Cole Cole NNP cord-347946-i6kx3n6m 282 63 , , , cord-347946-i6kx3n6m 282 64 2006 2006 CD cord-347946-i6kx3n6m 282 65 ; ; . cord-347946-i6kx3n6m 283 1 Schaller Schaller NNP cord-347946-i6kx3n6m 283 2 and and CC cord-347946-i6kx3n6m 283 3 Murray Murray NNP cord-347946-i6kx3n6m 283 4 , , , cord-347946-i6kx3n6m 283 5 2008 2008 CD cord-347946-i6kx3n6m 283 6 ) ) -RRB- cord-347946-i6kx3n6m 283 7 . . . cord-347946-i6kx3n6m 284 1 Indeed indeed RB cord-347946-i6kx3n6m 284 2 , , , cord-347946-i6kx3n6m 284 3 given give VBN cord-347946-i6kx3n6m 284 4 evidence evidence NN cord-347946-i6kx3n6m 284 5 that that IN cord-347946-i6kx3n6m 284 6 merely merely RB cord-347946-i6kx3n6m 284 7 viewing view VBG cord-347946-i6kx3n6m 284 8 pictures picture NNS cord-347946-i6kx3n6m 284 9 of of IN cord-347946-i6kx3n6m 284 10 a a DT cord-347946-i6kx3n6m 284 11 sick sick JJ cord-347946-i6kx3n6m 284 12 individual individual NN cord-347946-i6kx3n6m 284 13 activates activate VBZ cord-347946-i6kx3n6m 284 14 the the DT cord-347946-i6kx3n6m 284 15 viewer viewer NN cord-347946-i6kx3n6m 284 16 's 's POS cord-347946-i6kx3n6m 284 17 innate innate JJ cord-347946-i6kx3n6m 284 18 immune immune JJ cord-347946-i6kx3n6m 284 19 system system NN cord-347946-i6kx3n6m 284 20 ( ( -LRB- cord-347946-i6kx3n6m 284 21 Schaller Schaller NNP cord-347946-i6kx3n6m 284 22 et et NNP cord-347946-i6kx3n6m 284 23 al al NNP cord-347946-i6kx3n6m 284 24 , , , cord-347946-i6kx3n6m 284 25 2010 2010 CD cord-347946-i6kx3n6m 284 26 ) ) -RRB- cord-347946-i6kx3n6m 284 27 , , , cord-347946-i6kx3n6m 284 28 it -PRON- PRP cord-347946-i6kx3n6m 284 29 may may MD cord-347946-i6kx3n6m 284 30 be be VB cord-347946-i6kx3n6m 284 31 that that IN cord-347946-i6kx3n6m 284 32 by by IN cord-347946-i6kx3n6m 284 33 prepotently prepotently RB cord-347946-i6kx3n6m 284 34 activating activate VBG cord-347946-i6kx3n6m 284 35 the the DT cord-347946-i6kx3n6m 284 36 innate innate JJ cord-347946-i6kx3n6m 284 37 immune immune JJ cord-347946-i6kx3n6m 284 38 responses response NNS cord-347946-i6kx3n6m 284 39 in in IN cord-347946-i6kx3n6m 284 40 one one PRP cord-347946-i6kx3n6m 284 41 's 's POS cord-347946-i6kx3n6m 284 42 kin kin NN cord-347946-i6kx3n6m 284 43 , , , cord-347946-i6kx3n6m 284 44 depression depression NN cord-347946-i6kx3n6m 284 45 served serve VBD cord-347946-i6kx3n6m 284 46 as as IN cord-347946-i6kx3n6m 284 47 an an DT cord-347946-i6kx3n6m 284 48 early early JJ cord-347946-i6kx3n6m 284 49 warning warning NN cord-347946-i6kx3n6m 284 50 system system NN cord-347946-i6kx3n6m 284 51 for for IN cord-347946-i6kx3n6m 284 52 increased increase VBN cord-347946-i6kx3n6m 284 53 infectious infectious JJ cord-347946-i6kx3n6m 284 54 risk risk NN cord-347946-i6kx3n6m 284 55 . . . cord-347946-i6kx3n6m 285 1 In in IN cord-347946-i6kx3n6m 285 2 this this DT cord-347946-i6kx3n6m 285 3 regard regard NN cord-347946-i6kx3n6m 285 4 , , , cord-347946-i6kx3n6m 285 5 it -PRON- PRP cord-347946-i6kx3n6m 285 6 is be VBZ cord-347946-i6kx3n6m 285 7 interesting interesting JJ cord-347946-i6kx3n6m 285 8 to to TO cord-347946-i6kx3n6m 285 9 note note VB cord-347946-i6kx3n6m 285 10 that that IN cord-347946-i6kx3n6m 285 11 associating associate VBG cord-347946-i6kx3n6m 285 12 with with IN cord-347946-i6kx3n6m 285 13 depressed depressed JJ cord-347946-i6kx3n6m 285 14 individuals individual NNS cord-347946-i6kx3n6m 285 15 increases increase VBZ cord-347946-i6kx3n6m 285 16 the the DT cord-347946-i6kx3n6m 285 17 risk risk NN cord-347946-i6kx3n6m 285 18 of of IN cord-347946-i6kx3n6m 285 19 developing develop VBG cord-347946-i6kx3n6m 285 20 depression depression NN cord-347946-i6kx3n6m 285 21 oneself oneself PRP cord-347946-i6kx3n6m 285 22 ( ( -LRB- cord-347946-i6kx3n6m 285 23 Fowler Fowler NNP cord-347946-i6kx3n6m 285 24 and and CC cord-347946-i6kx3n6m 285 25 Christakis Christakis NNP cord-347946-i6kx3n6m 285 26 , , , cord-347946-i6kx3n6m 285 27 2008 2008 CD cord-347946-i6kx3n6m 285 28 ) ) -RRB- cord-347946-i6kx3n6m 285 29 , , , cord-347946-i6kx3n6m 285 30 exactly exactly RB cord-347946-i6kx3n6m 285 31 as as IN cord-347946-i6kx3n6m 285 32 would would MD cord-347946-i6kx3n6m 285 33 be be VB cord-347946-i6kx3n6m 285 34 predicted predict VBN cord-347946-i6kx3n6m 285 35 if if IN cord-347946-i6kx3n6m 285 36 depression depression NN cord-347946-i6kx3n6m 285 37 served serve VBD cord-347946-i6kx3n6m 285 38 as as IN cord-347946-i6kx3n6m 285 39 an an DT cord-347946-i6kx3n6m 285 40 early early JJ cord-347946-i6kx3n6m 285 41 warning warning NN cord-347946-i6kx3n6m 285 42 signal signal NN cord-347946-i6kx3n6m 285 43 to to IN cord-347946-i6kx3n6m 285 44 others other NNS cord-347946-i6kx3n6m 285 45 of of IN cord-347946-i6kx3n6m 285 46 infectious infectious JJ cord-347946-i6kx3n6m 285 47 risk risk NN cord-347946-i6kx3n6m 285 48 and and CC cord-347946-i6kx3n6m 285 49 if if IN cord-347946-i6kx3n6m 285 50 depression depression NN cord-347946-i6kx3n6m 285 51 enhanced enhance VBN cord-347946-i6kx3n6m 285 52 host host NN cord-347946-i6kx3n6m 285 53 pathogen pathogen NN cord-347946-i6kx3n6m 285 54 defense defense NN cord-347946-i6kx3n6m 285 55 by by IN cord-347946-i6kx3n6m 285 56 priming prime VBG cord-347946-i6kx3n6m 285 57 the the DT cord-347946-i6kx3n6m 285 58 innate innate JJ cord-347946-i6kx3n6m 285 59 immune immune JJ cord-347946-i6kx3n6m 285 60 system system NN cord-347946-i6kx3n6m 285 61 . . . cord-347946-i6kx3n6m 286 1 A a DT cord-347946-i6kx3n6m 286 2 clear clear JJ cord-347946-i6kx3n6m 286 3 prediction prediction NN cord-347946-i6kx3n6m 286 4 of of IN cord-347946-i6kx3n6m 286 5 this this DT cord-347946-i6kx3n6m 286 6 line line NN cord-347946-i6kx3n6m 286 7 of of IN cord-347946-i6kx3n6m 286 8 reasoning reasoning NN cord-347946-i6kx3n6m 286 9 that that WDT cord-347946-i6kx3n6m 286 10 awaits await VBZ cord-347946-i6kx3n6m 286 11 testing testing NN cord-347946-i6kx3n6m 286 12 is be VBZ cord-347946-i6kx3n6m 286 13 that that IN cord-347946-i6kx3n6m 286 14 viewing view VBG cord-347946-i6kx3n6m 286 15 images image NNS cord-347946-i6kx3n6m 286 16 of of IN cord-347946-i6kx3n6m 286 17 depressed depressed JJ cord-347946-i6kx3n6m 286 18 individuals individual NNS cord-347946-i6kx3n6m 286 19 should should MD cord-347946-i6kx3n6m 286 20 activate activate VB cord-347946-i6kx3n6m 286 21 the the DT cord-347946-i6kx3n6m 286 22 immune immune JJ cord-347946-i6kx3n6m 286 23 system system NN cord-347946-i6kx3n6m 286 24 . . . cord-347946-i6kx3n6m 287 1 In in IN cord-347946-i6kx3n6m 287 2 addition addition NN cord-347946-i6kx3n6m 287 3 to to IN cord-347946-i6kx3n6m 287 4 potential potential JJ cord-347946-i6kx3n6m 287 5 inclusive inclusive JJ cord-347946-i6kx3n6m 287 6 fitness fitness NN cord-347946-i6kx3n6m 287 7 benefits benefit NNS cord-347946-i6kx3n6m 287 8 , , , cord-347946-i6kx3n6m 287 9 any any DT cord-347946-i6kx3n6m 287 10 decrement decrement NN cord-347946-i6kx3n6m 287 11 in in IN cord-347946-i6kx3n6m 287 12 survival survival NN cord-347946-i6kx3n6m 287 13 from from IN cord-347946-i6kx3n6m 287 14 depression depression NN cord-347946-i6kx3n6m 287 15 - - HYPH cord-347946-i6kx3n6m 287 16 induced induce VBN cord-347946-i6kx3n6m 287 17 loss loss NN cord-347946-i6kx3n6m 287 18 of of IN cord-347946-i6kx3n6m 287 19 social social JJ cord-347946-i6kx3n6m 287 20 aid aid NN cord-347946-i6kx3n6m 287 21 might may MD cord-347946-i6kx3n6m 287 22 have have VB cord-347946-i6kx3n6m 287 23 been be VBN cord-347946-i6kx3n6m 287 24 more more JJR cord-347946-i6kx3n6m 287 25 than than IN cord-347946-i6kx3n6m 287 26 offset offset VBN cord-347946-i6kx3n6m 287 27 by by IN cord-347946-i6kx3n6m 287 28 reduced reduce VBN cord-347946-i6kx3n6m 287 29 risk risk NN cord-347946-i6kx3n6m 287 30 of of IN cord-347946-i6kx3n6m 287 31 exposure exposure NN cord-347946-i6kx3n6m 287 32 to to IN cord-347946-i6kx3n6m 287 33 other other JJ cord-347946-i6kx3n6m 287 34 pathogens pathogen NNS cord-347946-i6kx3n6m 287 35 while while IN cord-347946-i6kx3n6m 287 36 in in IN cord-347946-i6kx3n6m 287 37 a a DT cord-347946-i6kx3n6m 287 38 vulnerable vulnerable JJ cord-347946-i6kx3n6m 287 39 state state NN cord-347946-i6kx3n6m 287 40 due due IN cord-347946-i6kx3n6m 287 41 to to IN cord-347946-i6kx3n6m 287 42 a a DT cord-347946-i6kx3n6m 287 43 pre pre JJ cord-347946-i6kx3n6m 287 44 - - JJ cord-347946-i6kx3n6m 287 45 existing existing JJ cord-347946-i6kx3n6m 287 46 infection infection NN cord-347946-i6kx3n6m 287 47 , , , cord-347946-i6kx3n6m 287 48 given give VBN cord-347946-i6kx3n6m 287 49 that that IN cord-347946-i6kx3n6m 287 50 viral viral JJ cord-347946-i6kx3n6m 287 51 infections infection NNS cord-347946-i6kx3n6m 287 52 promote promote VBP cord-347946-i6kx3n6m 287 53 aggressive aggressive JJ cord-347946-i6kx3n6m 287 54 immune immune JJ cord-347946-i6kx3n6m 287 55 responses response NNS cord-347946-i6kx3n6m 287 56 to to IN cord-347946-i6kx3n6m 287 57 bacterial bacterial JJ cord-347946-i6kx3n6m 287 58 superinfections superinfection NNS cord-347946-i6kx3n6m 287 59 that that WDT cord-347946-i6kx3n6m 287 60 can can MD cord-347946-i6kx3n6m 287 61 greatly greatly RB cord-347946-i6kx3n6m 287 62 increase increase VB cord-347946-i6kx3n6m 287 63 mortality mortality NN cord-347946-i6kx3n6m 287 64 ( ( -LRB- cord-347946-i6kx3n6m 287 65 Degre Degre NNP cord-347946-i6kx3n6m 287 66 and and CC cord-347946-i6kx3n6m 287 67 Glasgow Glasgow NNP cord-347946-i6kx3n6m 287 68 , , , cord-347946-i6kx3n6m 287 69 1968 1968 CD cord-347946-i6kx3n6m 287 70 ; ; : cord-347946-i6kx3n6m 287 71 Jakab Jakab NNP cord-347946-i6kx3n6m 287 72 and and CC cord-347946-i6kx3n6m 287 73 Dick Dick NNP cord-347946-i6kx3n6m 287 74 , , , cord-347946-i6kx3n6m 287 75 1973 1973 CD cord-347946-i6kx3n6m 287 76 ; ; : cord-347946-i6kx3n6m 287 77 Jones Jones NNP cord-347946-i6kx3n6m 287 78 et et NNP cord-347946-i6kx3n6m 287 79 al al NNP cord-347946-i6kx3n6m 287 80 , , , cord-347946-i6kx3n6m 287 81 1983 1983 CD cord-347946-i6kx3n6m 287 82 ; ; : cord-347946-i6kx3n6m 288 1 Nguyen Nguyen NNP cord-347946-i6kx3n6m 288 2 and and CC cord-347946-i6kx3n6m 288 3 Biron Biron NNP cord-347946-i6kx3n6m 288 4 , , , cord-347946-i6kx3n6m 288 5 1999 1999 CD cord-347946-i6kx3n6m 288 6 ; ; : cord-347946-i6kx3n6m 288 7 Molyneux Molyneux NNP cord-347946-i6kx3n6m 288 8 et et NNP cord-347946-i6kx3n6m 288 9 al al NNP cord-347946-i6kx3n6m 288 10 , , , cord-347946-i6kx3n6m 288 11 2003 2003 CD cord-347946-i6kx3n6m 288 12 ; ; : cord-347946-i6kx3n6m 288 13 Beadling Beadling NNP cord-347946-i6kx3n6m 288 14 and and CC cord-347946-i6kx3n6m 288 15 Slifka Slifka NNP cord-347946-i6kx3n6m 288 16 , , , cord-347946-i6kx3n6m 288 17 2004 2004 CD cord-347946-i6kx3n6m 288 18 ; ; : cord-347946-i6kx3n6m 288 19 McCullers McCullers NNP cord-347946-i6kx3n6m 288 20 et et NNP cord-347946-i6kx3n6m 288 21 al al NNP cord-347946-i6kx3n6m 288 22 , , , cord-347946-i6kx3n6m 288 23 2010 2010 CD cord-347946-i6kx3n6m 288 24 ) ) -RRB- cord-347946-i6kx3n6m 288 25 . . . cord-347946-i6kx3n6m 289 1 Moreover moreover RB cord-347946-i6kx3n6m 289 2 , , , cord-347946-i6kx3n6m 289 3 social social JJ cord-347946-i6kx3n6m 289 4 withdrawal withdrawal NN cord-347946-i6kx3n6m 289 5 and and CC cord-347946-i6kx3n6m 289 6 reduced reduce VBN cord-347946-i6kx3n6m 289 7 environmental environmental JJ cord-347946-i6kx3n6m 289 8 exploration exploration NN cord-347946-i6kx3n6m 289 9 might may MD cord-347946-i6kx3n6m 289 10 also also RB cord-347946-i6kx3n6m 289 11 have have VB cord-347946-i6kx3n6m 289 12 promoted promote VBN cord-347946-i6kx3n6m 289 13 individual individual JJ cord-347946-i6kx3n6m 289 14 survival survival NN cord-347946-i6kx3n6m 289 15 by by IN cord-347946-i6kx3n6m 289 16 limiting limit VBG cord-347946-i6kx3n6m 289 17 a a DT cord-347946-i6kx3n6m 289 18 depressed depressed JJ cord-347946-i6kx3n6m 289 19 individual individual NN cord-347946-i6kx3n6m 289 20 's 's POS cord-347946-i6kx3n6m 289 21 contact contact NN cord-347946-i6kx3n6m 289 22 with with IN cord-347946-i6kx3n6m 289 23 immunologically immunologically RB cord-347946-i6kx3n6m 289 24 dissimilar dissimilar JJ cord-347946-i6kx3n6m 289 25 out out JJ cord-347946-i6kx3n6m 289 26 - - HYPH cord-347946-i6kx3n6m 289 27 group group NN cord-347946-i6kx3n6m 289 28 members member NNS cord-347946-i6kx3n6m 289 29 who who WP cord-347946-i6kx3n6m 289 30 potentially potentially RB cord-347946-i6kx3n6m 289 31 harbored harbor VBD cord-347946-i6kx3n6m 289 32 pathogens pathogen NNS cord-347946-i6kx3n6m 289 33 against against IN cord-347946-i6kx3n6m 289 34 which which WDT cord-347946-i6kx3n6m 289 35 the the DT cord-347946-i6kx3n6m 289 36 depressed depressed JJ cord-347946-i6kx3n6m 289 37 person person NN cord-347946-i6kx3n6m 289 38 would would MD cord-347946-i6kx3n6m 289 39 have have VB cord-347946-i6kx3n6m 289 40 had have VBN cord-347946-i6kx3n6m 289 41 reduced reduce VBN cord-347946-i6kx3n6m 289 42 immunity immunity NN cord-347946-i6kx3n6m 289 43 compared compare VBN cord-347946-i6kx3n6m 289 44 to to IN cord-347946-i6kx3n6m 289 45 pathogens pathogen NNS cord-347946-i6kx3n6m 289 46 endemic endemic JJ cord-347946-i6kx3n6m 289 47 in in IN cord-347946-i6kx3n6m 289 48 the the DT cord-347946-i6kx3n6m 289 49 home home NN cord-347946-i6kx3n6m 289 50 group group NN cord-347946-i6kx3n6m 289 51 Thornhill Thornhill NNP cord-347946-i6kx3n6m 289 52 et et NNP cord-347946-i6kx3n6m 289 53 al al NNP cord-347946-i6kx3n6m 289 54 , , , cord-347946-i6kx3n6m 289 55 2009 2009 CD cord-347946-i6kx3n6m 289 56 ) ) -RRB- cord-347946-i6kx3n6m 289 57 . . . cord-347946-i6kx3n6m 290 1 This this DT cord-347946-i6kx3n6m 290 2 idea idea NN cord-347946-i6kx3n6m 290 3 suggests suggest VBZ cord-347946-i6kx3n6m 290 4 a a DT cord-347946-i6kx3n6m 290 5 hypothesis hypothesis NN cord-347946-i6kx3n6m 290 6 that that IN cord-347946-i6kx3n6m 290 7 to to IN cord-347946-i6kx3n6m 290 8 our -PRON- PRP$ cord-347946-i6kx3n6m 290 9 knowledge knowledge NN cord-347946-i6kx3n6m 290 10 has have VBZ cord-347946-i6kx3n6m 290 11 never never RB cord-347946-i6kx3n6m 290 12 been be VBN cord-347946-i6kx3n6m 290 13 tested test VBN cord-347946-i6kx3n6m 290 14 that that IN cord-347946-i6kx3n6m 290 15 MDD MDD NNP cord-347946-i6kx3n6m 290 16 should should MD cord-347946-i6kx3n6m 290 17 be be VB cord-347946-i6kx3n6m 290 18 associated associate VBN cord-347946-i6kx3n6m 290 19 with with IN cord-347946-i6kx3n6m 290 20 increased increase VBN cord-347946-i6kx3n6m 290 21 xenophobia xenophobia NN cord-347946-i6kx3n6m 290 22 . . . cord-347946-i6kx3n6m 291 1 It -PRON- PRP cord-347946-i6kx3n6m 291 2 is be VBZ cord-347946-i6kx3n6m 291 3 intriguing intriguing JJ cord-347946-i6kx3n6m 291 4 to to TO cord-347946-i6kx3n6m 291 5 note note VB cord-347946-i6kx3n6m 291 6 , , , cord-347946-i6kx3n6m 291 7 however however RB cord-347946-i6kx3n6m 291 8 , , , cord-347946-i6kx3n6m 291 9 that that IN cord-347946-i6kx3n6m 291 10 endotoxin endotoxin NN cord-347946-i6kx3n6m 291 11 administration administration NN cord-347946-i6kx3n6m 291 12 increased increase VBD cord-347946-i6kx3n6m 291 13 the the DT cord-347946-i6kx3n6m 291 14 desire desire NN cord-347946-i6kx3n6m 291 15 of of IN cord-347946-i6kx3n6m 291 16 healthy healthy JJ cord-347946-i6kx3n6m 291 17 volunteers volunteer NNS cord-347946-i6kx3n6m 291 18 to to TO cord-347946-i6kx3n6m 291 19 be be VB cord-347946-i6kx3n6m 291 20 around around IN cord-347946-i6kx3n6m 291 21 individuals individual NNS cord-347946-i6kx3n6m 291 22 they -PRON- PRP cord-347946-i6kx3n6m 291 23 had have VBD cord-347946-i6kx3n6m 291 24 previously previously RB cord-347946-i6kx3n6m 291 25 identified identify VBN cord-347946-i6kx3n6m 291 26 as as IN cord-347946-i6kx3n6m 291 27 ' ' `` cord-347946-i6kx3n6m 291 28 support support NN cord-347946-i6kx3n6m 291 29 figures figure NNS cord-347946-i6kx3n6m 291 30 ' ' '' cord-347946-i6kx3n6m 291 31 ( ( -LRB- cord-347946-i6kx3n6m 291 32 Inagaki Inagaki NNP cord-347946-i6kx3n6m 291 33 et et NNP cord-347946-i6kx3n6m 291 34 al al NNP cord-347946-i6kx3n6m 291 35 , , , cord-347946-i6kx3n6m 291 36 2015 2015 CD cord-347946-i6kx3n6m 291 37 ) ) -RRB- cord-347946-i6kx3n6m 291 38 , , , cord-347946-i6kx3n6m 291 39 consistent consistent JJ cord-347946-i6kx3n6m 291 40 with with IN cord-347946-i6kx3n6m 291 41 the the DT cord-347946-i6kx3n6m 291 42 possibility possibility NN cord-347946-i6kx3n6m 291 43 that that IN cord-347946-i6kx3n6m 291 44 immune immune JJ cord-347946-i6kx3n6m 291 45 changes change NNS cord-347946-i6kx3n6m 291 46 associated associate VBN cord-347946-i6kx3n6m 291 47 with with IN cord-347946-i6kx3n6m 291 48 depression depression NN cord-347946-i6kx3n6m 291 49 might may MD cord-347946-i6kx3n6m 291 50 have have VB cord-347946-i6kx3n6m 291 51 promoted promote VBN cord-347946-i6kx3n6m 291 52 an an DT cord-347946-i6kx3n6m 291 53 in in IN cord-347946-i6kx3n6m 291 54 - - HYPH cord-347946-i6kx3n6m 291 55 group group NN cord-347946-i6kx3n6m 291 56 bias bias NN cord-347946-i6kx3n6m 291 57 that that WDT cord-347946-i6kx3n6m 291 58 reduced reduce VBD cord-347946-i6kx3n6m 291 59 exposure exposure NN cord-347946-i6kx3n6m 291 60 to to IN cord-347946-i6kx3n6m 291 61 more more RBR cord-347946-i6kx3n6m 291 62 potentially potentially RB cord-347946-i6kx3n6m 291 63 lethal lethal JJ cord-347946-i6kx3n6m 291 64 pathogens pathogen NNS cord-347946-i6kx3n6m 291 65 harbored harbor VBN cord-347946-i6kx3n6m 291 66 by by IN cord-347946-i6kx3n6m 291 67 members member NNS cord-347946-i6kx3n6m 291 68 of of IN cord-347946-i6kx3n6m 291 69 other other JJ cord-347946-i6kx3n6m 291 70 social social JJ cord-347946-i6kx3n6m 291 71 groups group NNS cord-347946-i6kx3n6m 291 72 . . . cord-347946-i6kx3n6m 292 1 How how WRB cord-347946-i6kx3n6m 292 2 such such PDT cord-347946-i6kx3n6m 292 3 an an DT cord-347946-i6kx3n6m 292 4 increased increase VBN cord-347946-i6kx3n6m 292 5 desire desire NN cord-347946-i6kx3n6m 292 6 to to TO cord-347946-i6kx3n6m 292 7 associate associate VB cord-347946-i6kx3n6m 292 8 with with IN cord-347946-i6kx3n6m 292 9 in in IN cord-347946-i6kx3n6m 292 10 - - HYPH cord-347946-i6kx3n6m 292 11 group group NN cord-347946-i6kx3n6m 292 12 members member NNS cord-347946-i6kx3n6m 292 13 would would MD cord-347946-i6kx3n6m 292 14 square square VB cord-347946-i6kx3n6m 292 15 with with IN cord-347946-i6kx3n6m 292 16 the the DT cord-347946-i6kx3n6m 292 17 potential potential JJ cord-347946-i6kx3n6m 292 18 selective selective JJ cord-347946-i6kx3n6m 292 19 advantages advantage NNS cord-347946-i6kx3n6m 292 20 of of IN cord-347946-i6kx3n6m 292 21 withdrawing withdraw VBG cord-347946-i6kx3n6m 292 22 from from IN cord-347946-i6kx3n6m 292 23 kin kin NNP cord-347946-i6kx3n6m 292 24 to to TO cord-347946-i6kx3n6m 292 25 prevent prevent VB cord-347946-i6kx3n6m 292 26 the the DT cord-347946-i6kx3n6m 292 27 spread spread NN cord-347946-i6kx3n6m 292 28 of of IN cord-347946-i6kx3n6m 292 29 infection infection NN cord-347946-i6kx3n6m 292 30 is be VBZ cord-347946-i6kx3n6m 292 31 unknown unknown JJ cord-347946-i6kx3n6m 292 32 . . . cord-347946-i6kx3n6m 293 1 Moreover moreover RB cord-347946-i6kx3n6m 293 2 , , , cord-347946-i6kx3n6m 293 3 given give VBN cord-347946-i6kx3n6m 293 4 that that IN cord-347946-i6kx3n6m 293 5 sterile sterile JJ cord-347946-i6kx3n6m 293 6 psychosocial psychosocial JJ cord-347946-i6kx3n6m 293 7 stressors stressor NNS cord-347946-i6kx3n6m 293 8 also also RB cord-347946-i6kx3n6m 293 9 activate activate VBP cord-347946-i6kx3n6m 293 10 inflammation inflammation NN cord-347946-i6kx3n6m 293 11 , , , cord-347946-i6kx3n6m 293 12 it -PRON- PRP cord-347946-i6kx3n6m 293 13 is be VBZ cord-347946-i6kx3n6m 293 14 intriguing intriguing JJ cord-347946-i6kx3n6m 293 15 to to TO cord-347946-i6kx3n6m 293 16 speculate speculate VB cord-347946-i6kx3n6m 293 17 that that IN cord-347946-i6kx3n6m 293 18 the the DT cord-347946-i6kx3n6m 293 19 benefits benefit NNS cord-347946-i6kx3n6m 293 20 of of IN cord-347946-i6kx3n6m 293 21 seeking seek VBG cord-347946-i6kx3n6m 293 22 support support NN cord-347946-i6kx3n6m 293 23 / / SYM cord-347946-i6kx3n6m 293 24 proximity proximity NN cord-347946-i6kx3n6m 293 25 with with IN cord-347946-i6kx3n6m 293 26 kin kin NN cord-347946-i6kx3n6m 293 27 / / SYM cord-347946-i6kx3n6m 293 28 in in IN cord-347946-i6kx3n6m 293 29 - - HYPH cord-347946-i6kx3n6m 293 30 group group NN cord-347946-i6kx3n6m 293 31 members member NNS cord-347946-i6kx3n6m 293 32 in in IN cord-347946-i6kx3n6m 293 33 response response NN cord-347946-i6kx3n6m 293 34 to to IN cord-347946-i6kx3n6m 293 35 psychosocial psychosocial JJ cord-347946-i6kx3n6m 293 36 dangers danger NNS cord-347946-i6kx3n6m 293 37 may may MD cord-347946-i6kx3n6m 293 38 have have VB cord-347946-i6kx3n6m 293 39 offset offset VBN cord-347946-i6kx3n6m 293 40 the the DT cord-347946-i6kx3n6m 293 41 potential potential JJ cord-347946-i6kx3n6m 293 42 risks risk NNS cord-347946-i6kx3n6m 293 43 of of IN cord-347946-i6kx3n6m 293 44 contagion contagion NN cord-347946-i6kx3n6m 293 45 spread spread VBD cord-347946-i6kx3n6m 293 46 as as IN cord-347946-i6kx3n6m 293 47 a a DT cord-347946-i6kx3n6m 293 48 result result NN cord-347946-i6kx3n6m 293 49 of of IN cord-347946-i6kx3n6m 293 50 inflammation inflammation NN cord-347946-i6kx3n6m 293 51 enhancing enhance VBG cord-347946-i6kx3n6m 293 52 prosocial prosocial JJ cord-347946-i6kx3n6m 293 53 behavior behavior NN cord-347946-i6kx3n6m 293 54 with with IN cord-347946-i6kx3n6m 293 55 trusted trust VBN cord-347946-i6kx3n6m 293 56 ingroup ingroup NNP cord-347946-i6kx3n6m 293 57 members member NNS cord-347946-i6kx3n6m 293 58 . . . cord-347946-i6kx3n6m 294 1 With with IN cord-347946-i6kx3n6m 294 2 the the DT cord-347946-i6kx3n6m 294 3 exception exception NN cord-347946-i6kx3n6m 294 4 of of IN cord-347946-i6kx3n6m 294 5 asthma asthma NN cord-347946-i6kx3n6m 294 6 and and CC cord-347946-i6kx3n6m 294 7 allergies allergy NNS cord-347946-i6kx3n6m 294 8 , , , cord-347946-i6kx3n6m 294 9 inflammatory inflammatory JJ cord-347946-i6kx3n6m 294 10 conditions condition NNS cord-347946-i6kx3n6m 294 11 typically typically RB cord-347946-i6kx3n6m 294 12 strike strike VBP cord-347946-i6kx3n6m 294 13 after after IN cord-347946-i6kx3n6m 294 14 the the DT cord-347946-i6kx3n6m 294 15 age age NN cord-347946-i6kx3n6m 294 16 of of IN cord-347946-i6kx3n6m 294 17 reproduction reproduction NN cord-347946-i6kx3n6m 294 18 , , , cord-347946-i6kx3n6m 294 19 and and CC cord-347946-i6kx3n6m 294 20 thus thus RB cord-347946-i6kx3n6m 294 21 alleles allele NNS cord-347946-i6kx3n6m 294 22 that that WDT cord-347946-i6kx3n6m 294 23 promote promote VBP cord-347946-i6kx3n6m 294 24 them -PRON- PRP cord-347946-i6kx3n6m 294 25 are be VBP cord-347946-i6kx3n6m 294 26 subject subject JJ cord-347946-i6kx3n6m 294 27 to to IN cord-347946-i6kx3n6m 294 28 minimal minimal JJ cord-347946-i6kx3n6m 294 29 selective selective JJ cord-347946-i6kx3n6m 294 30 pressure pressure NN cord-347946-i6kx3n6m 294 31 , , , cord-347946-i6kx3n6m 294 32 even even RB cord-347946-i6kx3n6m 294 33 in in IN cord-347946-i6kx3n6m 294 34 modern modern JJ cord-347946-i6kx3n6m 294 35 environments environment NNS cord-347946-i6kx3n6m 294 36 ( ( -LRB- cord-347946-i6kx3n6m 294 37 Beekman Beekman NNP cord-347946-i6kx3n6m 294 38 et et NNP cord-347946-i6kx3n6m 294 39 al al NNP cord-347946-i6kx3n6m 294 40 , , , cord-347946-i6kx3n6m 294 41 2010 2010 CD cord-347946-i6kx3n6m 294 42 ) ) -RRB- cord-347946-i6kx3n6m 294 43 . . . cord-347946-i6kx3n6m 295 1 Almost almost RB cord-347946-i6kx3n6m 295 2 certainly certainly RB cord-347946-i6kx3n6m 295 3 , , , cord-347946-i6kx3n6m 295 4 the the DT cord-347946-i6kx3n6m 295 5 association association NN cord-347946-i6kx3n6m 295 6 between between IN cord-347946-i6kx3n6m 295 7 chronic chronic JJ cord-347946-i6kx3n6m 295 8 inflammation inflammation NN cord-347946-i6kx3n6m 295 9 and and CC cord-347946-i6kx3n6m 295 10 these these DT cord-347946-i6kx3n6m 295 11 disease disease NN cord-347946-i6kx3n6m 295 12 states state NNS cord-347946-i6kx3n6m 295 13 ( ( -LRB- cord-347946-i6kx3n6m 295 14 eg eg IN cord-347946-i6kx3n6m 295 15 , , , cord-347946-i6kx3n6m 295 16 dementia dementia NN cord-347946-i6kx3n6m 295 17 and and CC cord-347946-i6kx3n6m 295 18 cardiovascular cardiovascular JJ cord-347946-i6kx3n6m 295 19 disease disease NN cord-347946-i6kx3n6m 295 20 ) ) -RRB- cord-347946-i6kx3n6m 295 21 serves serve VBZ cord-347946-i6kx3n6m 295 22 no no DT cord-347946-i6kx3n6m 295 23 adaptive adaptive JJ cord-347946-i6kx3n6m 295 24 purpose purpose NN cord-347946-i6kx3n6m 295 25 and and CC cord-347946-i6kx3n6m 295 26 likely likely JJ cord-347946-i6kx3n6m 295 27 results result NNS cord-347946-i6kx3n6m 295 28 in in IN cord-347946-i6kx3n6m 295 29 large large JJ cord-347946-i6kx3n6m 295 30 measure measure NN cord-347946-i6kx3n6m 295 31 from from IN cord-347946-i6kx3n6m 295 32 environmental environmental JJ cord-347946-i6kx3n6m 295 33 conditions condition NNS cord-347946-i6kx3n6m 295 34 unique unique JJ cord-347946-i6kx3n6m 295 35 to to IN cord-347946-i6kx3n6m 295 36 the the DT cord-347946-i6kx3n6m 295 37 modern modern JJ cord-347946-i6kx3n6m 295 38 world world NN cord-347946-i6kx3n6m 295 39 . . . cord-347946-i6kx3n6m 296 1 However however RB cord-347946-i6kx3n6m 296 2 , , , cord-347946-i6kx3n6m 296 3 the the DT cord-347946-i6kx3n6m 296 4 relationship relationship NN cord-347946-i6kx3n6m 296 5 between between IN cord-347946-i6kx3n6m 296 6 inflammation inflammation NN cord-347946-i6kx3n6m 296 7 and and CC cord-347946-i6kx3n6m 296 8 depression depression NN cord-347946-i6kx3n6m 296 9 is be VBZ cord-347946-i6kx3n6m 296 10 quite quite RB cord-347946-i6kx3n6m 296 11 different different JJ cord-347946-i6kx3n6m 296 12 , , , cord-347946-i6kx3n6m 296 13 given give VBN cord-347946-i6kx3n6m 296 14 that that IN cord-347946-i6kx3n6m 296 15 the the DT cord-347946-i6kx3n6m 296 16 incidence incidence NN cord-347946-i6kx3n6m 296 17 of of IN cord-347946-i6kx3n6m 296 18 MDD MDD NNP cord-347946-i6kx3n6m 296 19 peaks peak NNS cord-347946-i6kx3n6m 296 20 in in IN cord-347946-i6kx3n6m 296 21 the the DT cord-347946-i6kx3n6m 296 22 20 20 CD cord-347946-i6kx3n6m 296 23 - - SYM cord-347946-i6kx3n6m 296 24 30 30 CD cord-347946-i6kx3n6m 296 25 s s NN cord-347946-i6kx3n6m 296 26 ( ( -LRB- cord-347946-i6kx3n6m 296 27 Eaton Eaton NNP cord-347946-i6kx3n6m 296 28 et et NNP cord-347946-i6kx3n6m 296 29 al al NNP cord-347946-i6kx3n6m 296 30 , , , cord-347946-i6kx3n6m 296 31 1997 1997 CD cord-347946-i6kx3n6m 296 32 ; ; : cord-347946-i6kx3n6m 297 1 Patten Patten NNP cord-347946-i6kx3n6m 297 2 et et NNP cord-347946-i6kx3n6m 297 3 al al NNP cord-347946-i6kx3n6m 297 4 , , , cord-347946-i6kx3n6m 297 5 2006 2006 CD cord-347946-i6kx3n6m 297 6 ; ; : cord-347946-i6kx3n6m 297 7 Kessler Kessler NNP cord-347946-i6kx3n6m 297 8 et et NNP cord-347946-i6kx3n6m 297 9 al al NNP cord-347946-i6kx3n6m 297 10 , , , cord-347946-i6kx3n6m 297 11 2010 2010 CD cord-347946-i6kx3n6m 297 12 ) ) -RRB- cord-347946-i6kx3n6m 297 13 , , , cord-347946-i6kx3n6m 297 14 an an DT cord-347946-i6kx3n6m 297 15 age age NN cord-347946-i6kx3n6m 297 16 of of IN cord-347946-i6kx3n6m 297 17 primary primary JJ cord-347946-i6kx3n6m 297 18 reproductive reproductive JJ cord-347946-i6kx3n6m 297 19 / / SYM cord-347946-i6kx3n6m 297 20 childrearing childrearing NN cord-347946-i6kx3n6m 297 21 responsibilities responsibility NNS cord-347946-i6kx3n6m 297 22 . . . cord-347946-i6kx3n6m 298 1 In in IN cord-347946-i6kx3n6m 298 2 this this DT cord-347946-i6kx3n6m 298 3 , , , cord-347946-i6kx3n6m 298 4 MDD MDD NNP cord-347946-i6kx3n6m 298 5 is be VBZ cord-347946-i6kx3n6m 298 6 not not RB cord-347946-i6kx3n6m 298 7 alone alone JJ cord-347946-i6kx3n6m 298 8 . . . cord-347946-i6kx3n6m 299 1 Schizophrenia schizophrenia NN cord-347946-i6kx3n6m 299 2 and and CC cord-347946-i6kx3n6m 299 3 bipolar bipolar JJ cord-347946-i6kx3n6m 299 4 disorder disorder NN cord-347946-i6kx3n6m 300 1 -conditions -condition NNS cord-347946-i6kx3n6m 300 2 with with IN cord-347946-i6kx3n6m 300 3 which which WDT cord-347946-i6kx3n6m 300 4 MDD MDD NNP cord-347946-i6kx3n6m 300 5 is be VBZ cord-347946-i6kx3n6m 300 6 genetically genetically RB cord-347946-i6kx3n6m 300 7 linked link VBN cord-347946-i6kx3n6m 300 8 - - : cord-347946-i6kx3n6m 300 9 are be VBP cord-347946-i6kx3n6m 300 10 also also RB cord-347946-i6kx3n6m 300 11 characterized characterize VBN cord-347946-i6kx3n6m 300 12 by by IN cord-347946-i6kx3n6m 300 13 increased increase VBN cord-347946-i6kx3n6m 300 14 inflammation inflammation NN cord-347946-i6kx3n6m 300 15 and and CC cord-347946-i6kx3n6m 300 16 by by IN cord-347946-i6kx3n6m 300 17 an an DT cord-347946-i6kx3n6m 300 18 average average JJ cord-347946-i6kx3n6m 300 19 age age NN cord-347946-i6kx3n6m 300 20 of of IN cord-347946-i6kx3n6m 300 21 onset onset NN cord-347946-i6kx3n6m 300 22 early early RB cord-347946-i6kx3n6m 300 23 in in IN cord-347946-i6kx3n6m 300 24 life life NN cord-347946-i6kx3n6m 300 25 when when WRB cord-347946-i6kx3n6m 300 26 the the DT cord-347946-i6kx3n6m 300 27 costs cost NNS cord-347946-i6kx3n6m 300 28 of of IN cord-347946-i6kx3n6m 300 29 these these DT cord-347946-i6kx3n6m 300 30 disease disease NN cord-347946-i6kx3n6m 300 31 states state NNS cord-347946-i6kx3n6m 300 32 to to IN cord-347946-i6kx3n6m 300 33 survival survival NN cord-347946-i6kx3n6m 300 34 and and CC cord-347946-i6kx3n6m 300 35 reproduction reproduction NN cord-347946-i6kx3n6m 300 36 are be VBP cord-347946-i6kx3n6m 300 37 ( ( -LRB- cord-347946-i6kx3n6m 300 38 and and CC cord-347946-i6kx3n6m 300 39 were be VBD cord-347946-i6kx3n6m 300 40 ) ) -RRB- cord-347946-i6kx3n6m 300 41 likely likely JJ cord-347946-i6kx3n6m 300 42 to to TO cord-347946-i6kx3n6m 300 43 be be VB cord-347946-i6kx3n6m 300 44 maximal maximal JJ cord-347946-i6kx3n6m 300 45 . . . cord-347946-i6kx3n6m 301 1 Although although IN cord-347946-i6kx3n6m 301 2 the the DT cord-347946-i6kx3n6m 301 3 current current JJ cord-347946-i6kx3n6m 301 4 article article NN cord-347946-i6kx3n6m 301 5 focuses focus VBZ cord-347946-i6kx3n6m 301 6 on on IN cord-347946-i6kx3n6m 301 7 unipolar unipolar JJ cord-347946-i6kx3n6m 301 8 depression depression NN cord-347946-i6kx3n6m 301 9 , , , cord-347946-i6kx3n6m 301 10 there there EX cord-347946-i6kx3n6m 301 11 is be VBZ cord-347946-i6kx3n6m 301 12 no no DT cord-347946-i6kx3n6m 301 13 reason reason NN cord-347946-i6kx3n6m 301 14 to to TO cord-347946-i6kx3n6m 301 15 think think VB cord-347946-i6kx3n6m 301 16 that that IN cord-347946-i6kx3n6m 301 17 depressive depressive JJ cord-347946-i6kx3n6m 301 18 symptoms symptom NNS cord-347946-i6kx3n6m 301 19 occurring occur VBG cord-347946-i6kx3n6m 301 20 in in IN cord-347946-i6kx3n6m 301 21 the the DT cord-347946-i6kx3n6m 301 22 context context NN cord-347946-i6kx3n6m 301 23 of of IN cord-347946-i6kx3n6m 301 24 bipolar bipolar JJ cord-347946-i6kx3n6m 301 25 disorder disorder NN cord-347946-i6kx3n6m 301 26 would would MD cord-347946-i6kx3n6m 301 27 be be VB cord-347946-i6kx3n6m 301 28 any any DT cord-347946-i6kx3n6m 301 29 less less RBR cord-347946-i6kx3n6m 301 30 efficacious efficacious JJ cord-347946-i6kx3n6m 301 31 for for IN cord-347946-i6kx3n6m 301 32 pathogen pathogen NN cord-347946-i6kx3n6m 301 33 - - HYPH cord-347946-i6kx3n6m 301 34 host host NN cord-347946-i6kx3n6m 301 35 defense defense NN cord-347946-i6kx3n6m 301 36 than than IN cord-347946-i6kx3n6m 301 37 the the DT cord-347946-i6kx3n6m 301 38 same same JJ cord-347946-i6kx3n6m 301 39 symptoms symptom NNS cord-347946-i6kx3n6m 301 40 when when WRB cord-347946-i6kx3n6m 301 41 they -PRON- PRP cord-347946-i6kx3n6m 301 42 occur occur VBP cord-347946-i6kx3n6m 301 43 in in IN cord-347946-i6kx3n6m 301 44 other other JJ cord-347946-i6kx3n6m 301 45 contexts context NNS cord-347946-i6kx3n6m 301 46 , , , cord-347946-i6kx3n6m 301 47 and and CC cord-347946-i6kx3n6m 301 48 indeed indeed RB cord-347946-i6kx3n6m 301 49 multiple multiple JJ cord-347946-i6kx3n6m 301 50 studies study NNS cord-347946-i6kx3n6m 301 51 demonstrate demonstrate VBP cord-347946-i6kx3n6m 301 52 that that DT cord-347946-i6kx3n6m 301 53 bipolar bipolar JJ cord-347946-i6kx3n6m 301 54 depression depression NN cord-347946-i6kx3n6m 301 55 is be VBZ cord-347946-i6kx3n6m 301 56 associated associate VBN cord-347946-i6kx3n6m 301 57 with with IN cord-347946-i6kx3n6m 301 58 the the DT cord-347946-i6kx3n6m 301 59 same same JJ cord-347946-i6kx3n6m 301 60 types type NNS cord-347946-i6kx3n6m 301 61 of of IN cord-347946-i6kx3n6m 301 62 inflammatory inflammatory JJ cord-347946-i6kx3n6m 301 63 activation activation NN cord-347946-i6kx3n6m 301 64 that that WDT cord-347946-i6kx3n6m 301 65 are be VBP cord-347946-i6kx3n6m 301 66 observed observe VBN cord-347946-i6kx3n6m 301 67 in in IN cord-347946-i6kx3n6m 301 68 unipolar unipolar JJ cord-347946-i6kx3n6m 301 69 MDD MDD NNP cord-347946-i6kx3n6m 301 70 ( ( -LRB- cord-347946-i6kx3n6m 301 71 Goldstein Goldstein NNP cord-347946-i6kx3n6m 301 72 et et NNP cord-347946-i6kx3n6m 301 73 al al NNP cord-347946-i6kx3n6m 301 74 , , , cord-347946-i6kx3n6m 301 75 2009 2009 CD cord-347946-i6kx3n6m 301 76 ) ) -RRB- cord-347946-i6kx3n6m 301 77 . . . cord-347946-i6kx3n6m 302 1 However however RB cord-347946-i6kx3n6m 302 2 , , , cord-347946-i6kx3n6m 302 3 what what WP cord-347946-i6kx3n6m 302 4 should should MD cord-347946-i6kx3n6m 302 5 we -PRON- PRP cord-347946-i6kx3n6m 302 6 make make VB cord-347946-i6kx3n6m 302 7 of of IN cord-347946-i6kx3n6m 302 8 the the DT cord-347946-i6kx3n6m 302 9 fact fact NN cord-347946-i6kx3n6m 302 10 that that IN cord-347946-i6kx3n6m 302 11 multiple multiple JJ cord-347946-i6kx3n6m 302 12 studies study NNS cord-347946-i6kx3n6m 302 13 show show VBP cord-347946-i6kx3n6m 302 14 that that IN cord-347946-i6kx3n6m 302 15 inflammatory inflammatory JJ cord-347946-i6kx3n6m 302 16 markers marker NNS cord-347946-i6kx3n6m 302 17 are be VBP cord-347946-i6kx3n6m 302 18 at at IN cord-347946-i6kx3n6m 302 19 least least JJS cord-347946-i6kx3n6m 302 20 as as IN cord-347946-i6kx3n6m 302 21 elevated elevate VBN cord-347946-i6kx3n6m 302 22 - - : cord-347946-i6kx3n6m 302 23 and and CC cord-347946-i6kx3n6m 302 24 maybe maybe RB cord-347946-i6kx3n6m 302 25 more more RBR cord-347946-i6kx3n6m 302 26 elevated elevate VBN cord-347946-i6kx3n6m 302 27 - - HYPH cord-347946-i6kx3n6m 302 28 in in IN cord-347946-i6kx3n6m 302 29 manic manic JJ cord-347946-i6kx3n6m 302 30 episodes episode NNS cord-347946-i6kx3n6m 302 31 as as IN cord-347946-i6kx3n6m 302 32 they -PRON- PRP cord-347946-i6kx3n6m 302 33 are be VBP cord-347946-i6kx3n6m 302 34 during during IN cord-347946-i6kx3n6m 302 35 bipolar bipolar JJ cord-347946-i6kx3n6m 302 36 depressions depression NNS cord-347946-i6kx3n6m 302 37 ( ( -LRB- cord-347946-i6kx3n6m 302 38 Goldstein Goldstein NNP cord-347946-i6kx3n6m 302 39 et et NNP cord-347946-i6kx3n6m 302 40 al al NNP cord-347946-i6kx3n6m 302 41 , , , cord-347946-i6kx3n6m 302 42 2009 2009 CD cord-347946-i6kx3n6m 302 43 ) ) -RRB- cord-347946-i6kx3n6m 302 44 ? ? . cord-347946-i6kx3n6m 303 1 A a DT cord-347946-i6kx3n6m 303 2 proximal proximal JJ cord-347946-i6kx3n6m 303 3 answer answer NN cord-347946-i6kx3n6m 303 4 might may MD cord-347946-i6kx3n6m 303 5 point point VB cord-347946-i6kx3n6m 303 6 to to IN cord-347946-i6kx3n6m 303 7 the the DT cord-347946-i6kx3n6m 303 8 fact fact NN cord-347946-i6kx3n6m 303 9 that that IN cord-347946-i6kx3n6m 303 10 mania mania NN cord-347946-i6kx3n6m 303 11 is be VBZ cord-347946-i6kx3n6m 303 12 associated associate VBN cord-347946-i6kx3n6m 303 13 with with IN cord-347946-i6kx3n6m 303 14 many many JJ cord-347946-i6kx3n6m 303 15 of of IN cord-347946-i6kx3n6m 303 16 the the DT cord-347946-i6kx3n6m 303 17 same same JJ cord-347946-i6kx3n6m 303 18 neuroendocrine neuroendocrine JJ cord-347946-i6kx3n6m 303 19 abnormalities abnormality NNS cord-347946-i6kx3n6m 303 20 as as IN cord-347946-i6kx3n6m 303 21 depression depression NN cord-347946-i6kx3n6m 303 22 , , , cord-347946-i6kx3n6m 303 23 especially especially RB cord-347946-i6kx3n6m 303 24 glucocorticoid glucocorticoid JJ cord-347946-i6kx3n6m 303 25 resistance resistance NN cord-347946-i6kx3n6m 303 26 ( ( -LRB- cord-347946-i6kx3n6m 303 27 Schmider Schmider NNP cord-347946-i6kx3n6m 303 28 et et NNP cord-347946-i6kx3n6m 303 29 al al NNP cord-347946-i6kx3n6m 303 30 , , , cord-347946-i6kx3n6m 303 31 1995 1995 CD cord-347946-i6kx3n6m 303 32 ) ) -RRB- cord-347946-i6kx3n6m 303 33 , , , cord-347946-i6kx3n6m 303 34 which which WDT cord-347946-i6kx3n6m 303 35 is be VBZ cord-347946-i6kx3n6m 303 36 known know VBN cord-347946-i6kx3n6m 303 37 to to TO cord-347946-i6kx3n6m 303 38 release release VB cord-347946-i6kx3n6m 303 39 inflammatory inflammatory JJ cord-347946-i6kx3n6m 303 40 pathways pathway NNS cord-347946-i6kx3n6m 303 41 from from IN cord-347946-i6kx3n6m 303 42 inhibitory inhibitory JJ cord-347946-i6kx3n6m 303 43 control control NN cord-347946-i6kx3n6m 303 44 and and CC cord-347946-i6kx3n6m 303 45 which which WDT cord-347946-i6kx3n6m 303 46 has have VBZ cord-347946-i6kx3n6m 303 47 been be VBN cord-347946-i6kx3n6m 303 48 associated associate VBN cord-347946-i6kx3n6m 303 49 with with IN cord-347946-i6kx3n6m 303 50 increased increase VBN cord-347946-i6kx3n6m 303 51 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 303 52 cytokine cytokine NN cord-347946-i6kx3n6m 303 53 levels level NNS cord-347946-i6kx3n6m 303 54 in in IN cord-347946-i6kx3n6m 303 55 MDD MDD NNP cord-347946-i6kx3n6m 303 56 ( ( -LRB- cord-347946-i6kx3n6m 303 57 Maes Maes NNP cord-347946-i6kx3n6m 303 58 , , , cord-347946-i6kx3n6m 303 59 1999 1999 CD cord-347946-i6kx3n6m 303 60 ) ) -RRB- cord-347946-i6kx3n6m 303 61 . . . cord-347946-i6kx3n6m 304 1 Moreover moreover RB cord-347946-i6kx3n6m 304 2 , , , cord-347946-i6kx3n6m 304 3 although although IN cord-347946-i6kx3n6m 304 4 far far RB cord-347946-i6kx3n6m 304 5 less less RBR cord-347946-i6kx3n6m 304 6 common common JJ cord-347946-i6kx3n6m 304 7 than than IN cord-347946-i6kx3n6m 304 8 depression depression NN cord-347946-i6kx3n6m 304 9 , , , cord-347946-i6kx3n6m 304 10 full full JJ cord-347946-i6kx3n6m 304 11 manic manic JJ cord-347946-i6kx3n6m 304 12 episodes episode NNS cord-347946-i6kx3n6m 304 13 have have VBP cord-347946-i6kx3n6m 304 14 been be VBN cord-347946-i6kx3n6m 304 15 reported report VBN cord-347946-i6kx3n6m 304 16 during during IN cord-347946-i6kx3n6m 304 17 IFN IFN NNP cord-347946-i6kx3n6m 304 18 - - HYPH cord-347946-i6kx3n6m 304 19 α α NNP cord-347946-i6kx3n6m 304 20 therapy therapy NN cord-347946-i6kx3n6m 304 21 , , , cord-347946-i6kx3n6m 304 22 which which WDT cord-347946-i6kx3n6m 304 23 produces produce VBZ cord-347946-i6kx3n6m 304 24 chronic chronic JJ cord-347946-i6kx3n6m 304 25 immune immune JJ cord-347946-i6kx3n6m 304 26 activation activation NN cord-347946-i6kx3n6m 304 27 , , , cord-347946-i6kx3n6m 304 28 and and CC cord-347946-i6kx3n6m 304 29 combinations combination NNS cord-347946-i6kx3n6m 304 30 of of IN cord-347946-i6kx3n6m 304 31 depressive depressive JJ cord-347946-i6kx3n6m 304 32 and and CC cord-347946-i6kx3n6m 304 33 manic manic JJ cord-347946-i6kx3n6m 304 34 symptoms symptom NNS cord-347946-i6kx3n6m 304 35 during during IN cord-347946-i6kx3n6m 304 36 IFN IFN NNP cord-347946-i6kx3n6m 304 37 - - HYPH cord-347946-i6kx3n6m 304 38 α α NNP cord-347946-i6kx3n6m 304 39 treatment treatment NN cord-347946-i6kx3n6m 304 40 are be VBP cord-347946-i6kx3n6m 304 41 common common JJ cord-347946-i6kx3n6m 305 1 ( ( -LRB- cord-347946-i6kx3n6m 305 2 Constant constant JJ cord-347946-i6kx3n6m 305 3 et et FW cord-347946-i6kx3n6m 305 4 al al NNP cord-347946-i6kx3n6m 305 5 , , , cord-347946-i6kx3n6m 305 6 2005 2005 CD cord-347946-i6kx3n6m 305 7 ) ) -RRB- cord-347946-i6kx3n6m 305 8 . . . cord-347946-i6kx3n6m 306 1 However however RB cord-347946-i6kx3n6m 306 2 , , , cord-347946-i6kx3n6m 306 3 this this DT cord-347946-i6kx3n6m 306 4 type type NN cord-347946-i6kx3n6m 306 5 of of IN cord-347946-i6kx3n6m 306 6 answer answer NN cord-347946-i6kx3n6m 306 7 provides provide VBZ cord-347946-i6kx3n6m 306 8 no no DT cord-347946-i6kx3n6m 306 9 insight insight NN cord-347946-i6kx3n6m 306 10 into into IN cord-347946-i6kx3n6m 306 11 why why WRB cord-347946-i6kx3n6m 306 12 mania mania NN cord-347946-i6kx3n6m 306 13 should should MD cord-347946-i6kx3n6m 306 14 be be VB cord-347946-i6kx3n6m 306 15 associated associate VBN cord-347946-i6kx3n6m 306 16 with with IN cord-347946-i6kx3n6m 306 17 increased increase VBN cord-347946-i6kx3n6m 306 18 inflammation inflammation NN cord-347946-i6kx3n6m 306 19 . . . cord-347946-i6kx3n6m 307 1 Might may MD cord-347946-i6kx3n6m 307 2 the the DT cord-347946-i6kx3n6m 307 3 association association NN cord-347946-i6kx3n6m 307 4 serve serve VB cord-347946-i6kx3n6m 307 5 adaptive adaptive JJ cord-347946-i6kx3n6m 307 6 purposes purpose NNS cord-347946-i6kx3n6m 307 7 or or CC cord-347946-i6kx3n6m 307 8 is be VBZ cord-347946-i6kx3n6m 307 9 it -PRON- PRP cord-347946-i6kx3n6m 307 10 better well RBR cord-347946-i6kx3n6m 307 11 considered consider VBN cord-347946-i6kx3n6m 307 12 as as IN cord-347946-i6kx3n6m 307 13 an an DT cord-347946-i6kx3n6m 307 14 example example NN cord-347946-i6kx3n6m 307 15 of of IN cord-347946-i6kx3n6m 307 16 antagonistic antagonistic JJ cord-347946-i6kx3n6m 307 17 pleiotropy pleiotropy NN cord-347946-i6kx3n6m 307 18 ? ? . cord-347946-i6kx3n6m 308 1 Here here RB cord-347946-i6kx3n6m 308 2 PATHOS PATHOS NNP cord-347946-i6kx3n6m 308 3 - - HYPH cord-347946-i6kx3n6m 308 4 D D NNP cord-347946-i6kx3n6m 308 5 offers offer VBZ cord-347946-i6kx3n6m 308 6 a a DT cord-347946-i6kx3n6m 308 7 novel novel JJ cord-347946-i6kx3n6m 308 8 perspective perspective NN cord-347946-i6kx3n6m 308 9 . . . cord-347946-i6kx3n6m 309 1 Until until IN cord-347946-i6kx3n6m 309 2 it -PRON- PRP cord-347946-i6kx3n6m 309 3 becomes become VBZ cord-347946-i6kx3n6m 309 4 disabling disable VBG cord-347946-i6kx3n6m 309 5 , , , cord-347946-i6kx3n6m 309 6 mania mania NN cord-347946-i6kx3n6m 309 7 increases increase VBZ cord-347946-i6kx3n6m 309 8 the the DT cord-347946-i6kx3n6m 309 9 types type NNS cord-347946-i6kx3n6m 309 10 of of IN cord-347946-i6kx3n6m 309 11 social social JJ cord-347946-i6kx3n6m 309 12 and and CC cord-347946-i6kx3n6m 309 13 sexual sexual JJ cord-347946-i6kx3n6m 309 14 extroversion extroversion NN cord-347946-i6kx3n6m 309 15 that that WDT cord-347946-i6kx3n6m 309 16 may may MD cord-347946-i6kx3n6m 309 17 provide provide VB cord-347946-i6kx3n6m 309 18 direct direct JJ cord-347946-i6kx3n6m 309 19 Darwinian darwinian JJ cord-347946-i6kx3n6m 309 20 benefits benefit NNS cord-347946-i6kx3n6m 309 21 as as IN cord-347946-i6kx3n6m 309 22 a a DT cord-347946-i6kx3n6m 309 23 result result NN cord-347946-i6kx3n6m 309 24 of of IN cord-347946-i6kx3n6m 309 25 increased increase VBN cord-347946-i6kx3n6m 309 26 opportunities opportunity NNS cord-347946-i6kx3n6m 309 27 for for IN cord-347946-i6kx3n6m 309 28 reproduction reproduction NN cord-347946-i6kx3n6m 309 29 ( ( -LRB- cord-347946-i6kx3n6m 309 30 Berry Berry NNP cord-347946-i6kx3n6m 309 31 and and CC cord-347946-i6kx3n6m 309 32 Miller Miller NNP cord-347946-i6kx3n6m 309 33 , , , cord-347946-i6kx3n6m 309 34 2001 2001 CD cord-347946-i6kx3n6m 309 35 ) ) -RRB- cord-347946-i6kx3n6m 309 36 . . . cord-347946-i6kx3n6m 310 1 However however RB cord-347946-i6kx3n6m 310 2 , , , cord-347946-i6kx3n6m 310 3 increased increase VBN cord-347946-i6kx3n6m 310 4 social social JJ cord-347946-i6kx3n6m 310 5 and and CC cord-347946-i6kx3n6m 310 6 sexual sexual JJ cord-347946-i6kx3n6m 310 7 activity activity NN cord-347946-i6kx3n6m 310 8 also also RB cord-347946-i6kx3n6m 310 9 increase increase VBP cord-347946-i6kx3n6m 310 10 the the DT cord-347946-i6kx3n6m 310 11 risk risk NN cord-347946-i6kx3n6m 310 12 for for IN cord-347946-i6kx3n6m 310 13 reduced reduce VBN cord-347946-i6kx3n6m 310 14 survival survival NN cord-347946-i6kx3n6m 310 15 as as IN cord-347946-i6kx3n6m 310 16 a a DT cord-347946-i6kx3n6m 310 17 result result NN cord-347946-i6kx3n6m 310 18 of of IN cord-347946-i6kx3n6m 310 19 increased increase VBN cord-347946-i6kx3n6m 310 20 pathogen pathogen NN cord-347946-i6kx3n6m 310 21 exposure exposure NN cord-347946-i6kx3n6m 310 22 ( ( -LRB- cord-347946-i6kx3n6m 310 23 Hamrick Hamrick NNP cord-347946-i6kx3n6m 310 24 et et NNP cord-347946-i6kx3n6m 310 25 al al NNP cord-347946-i6kx3n6m 310 26 , , , cord-347946-i6kx3n6m 310 27 2002 2002 CD cord-347946-i6kx3n6m 310 28 ) ) -RRB- cord-347946-i6kx3n6m 310 29 . . . cord-347946-i6kx3n6m 311 1 In in IN cord-347946-i6kx3n6m 311 2 this this DT cord-347946-i6kx3n6m 311 3 context context NN cord-347946-i6kx3n6m 311 4 , , , cord-347946-i6kx3n6m 311 5 might may MD cord-347946-i6kx3n6m 311 6 genes gene NNS cord-347946-i6kx3n6m 311 7 linking link VBG cord-347946-i6kx3n6m 311 8 inflammation inflammation NN cord-347946-i6kx3n6m 311 9 with with IN cord-347946-i6kx3n6m 311 10 mania mania NN cord-347946-i6kx3n6m 311 11 have have VBP cord-347946-i6kx3n6m 311 12 undergone undergo VBN cord-347946-i6kx3n6m 311 13 positive positive JJ cord-347946-i6kx3n6m 311 14 selection selection NN cord-347946-i6kx3n6m 311 15 by by IN cord-347946-i6kx3n6m 311 16 conferring confer VBG cord-347946-i6kx3n6m 311 17 increased increase VBN cord-347946-i6kx3n6m 311 18 protection protection NN cord-347946-i6kx3n6m 311 19 against against IN cord-347946-i6kx3n6m 311 20 the the DT cord-347946-i6kx3n6m 311 21 wide wide JJ cord-347946-i6kx3n6m 311 22 range range NN cord-347946-i6kx3n6m 311 23 of of IN cord-347946-i6kx3n6m 311 24 infections infection NNS cord-347946-i6kx3n6m 311 25 to to IN cord-347946-i6kx3n6m 311 26 which which WDT cord-347946-i6kx3n6m 311 27 manic manic JJ cord-347946-i6kx3n6m 311 28 behavior behavior NN cord-347946-i6kx3n6m 311 29 would would MD cord-347946-i6kx3n6m 311 30 have have VB cord-347946-i6kx3n6m 311 31 exposed expose VBN cord-347946-i6kx3n6m 311 32 an an DT cord-347946-i6kx3n6m 311 33 individual individual NN cord-347946-i6kx3n6m 311 34 in in IN cord-347946-i6kx3n6m 311 35 the the DT cord-347946-i6kx3n6m 311 36 EEA EEA NNP cord-347946-i6kx3n6m 311 37 ? ? . cord-347946-i6kx3n6m 312 1 Although although IN cord-347946-i6kx3n6m 312 2 highly highly RB cord-347946-i6kx3n6m 312 3 speculative speculative JJ cord-347946-i6kx3n6m 312 4 , , , cord-347946-i6kx3n6m 312 5 this this DT cord-347946-i6kx3n6m 312 6 hypothesis hypothesis NN cord-347946-i6kx3n6m 312 7 produces produce VBZ cord-347946-i6kx3n6m 312 8 the the DT cord-347946-i6kx3n6m 312 9 clear clear JJ cord-347946-i6kx3n6m 312 10 prediction prediction NN cord-347946-i6kx3n6m 312 11 that that IN cord-347946-i6kx3n6m 312 12 the the DT cord-347946-i6kx3n6m 312 13 increased increase VBN cord-347946-i6kx3n6m 312 14 inflammation inflammation NN cord-347946-i6kx3n6m 312 15 observed observe VBN cord-347946-i6kx3n6m 312 16 in in IN cord-347946-i6kx3n6m 312 17 mania mania NN cord-347946-i6kx3n6m 312 18 should should MD cord-347946-i6kx3n6m 312 19 be be VB cord-347946-i6kx3n6m 312 20 associated associate VBN cord-347946-i6kx3n6m 312 21 with with IN cord-347946-i6kx3n6m 312 22 the the DT cord-347946-i6kx3n6m 312 23 symptom symptom NN cord-347946-i6kx3n6m 312 24 of of IN cord-347946-i6kx3n6m 312 25 hypersexuality hypersexuality NN cord-347946-i6kx3n6m 312 26 , , , cord-347946-i6kx3n6m 312 27 especially especially RB cord-347946-i6kx3n6m 312 28 in in IN cord-347946-i6kx3n6m 312 29 males male NNS cord-347946-i6kx3n6m 312 30 , , , cord-347946-i6kx3n6m 312 31 who who WP cord-347946-i6kx3n6m 312 32 across across IN cord-347946-i6kx3n6m 312 33 evolutionary evolutionary JJ cord-347946-i6kx3n6m 312 34 time time NN cord-347946-i6kx3n6m 312 35 would would MD cord-347946-i6kx3n6m 312 36 have have VB cord-347946-i6kx3n6m 312 37 been be VBN cord-347946-i6kx3n6m 312 38 more more RBR cord-347946-i6kx3n6m 312 39 likely likely JJ cord-347946-i6kx3n6m 312 40 than than IN cord-347946-i6kx3n6m 312 41 females female NNS cord-347946-i6kx3n6m 312 42 to to TO cord-347946-i6kx3n6m 312 43 benefit benefit VB cord-347946-i6kx3n6m 312 44 in in IN cord-347946-i6kx3n6m 312 45 terms term NNS cord-347946-i6kx3n6m 312 46 of of IN cord-347946-i6kx3n6m 312 47 reproductive reproductive JJ cord-347946-i6kx3n6m 312 48 success success NN cord-347946-i6kx3n6m 312 49 from from IN cord-347946-i6kx3n6m 312 50 sexual sexual JJ cord-347946-i6kx3n6m 312 51 activity activity NN cord-347946-i6kx3n6m 312 52 with with IN cord-347946-i6kx3n6m 312 53 multiple multiple JJ cord-347946-i6kx3n6m 312 54 partners partner NNS cord-347946-i6kx3n6m 312 55 . . . cord-347946-i6kx3n6m 313 1 Interestingly interestingly RB cord-347946-i6kx3n6m 313 2 , , , cord-347946-i6kx3n6m 313 3 animal animal NN cord-347946-i6kx3n6m 313 4 data datum NNS cord-347946-i6kx3n6m 313 5 provide provide VBP cord-347946-i6kx3n6m 313 6 some some DT cord-347946-i6kx3n6m 313 7 evidence evidence NN cord-347946-i6kx3n6m 313 8 for for IN cord-347946-i6kx3n6m 313 9 this this DT cord-347946-i6kx3n6m 313 10 possibility possibility NN cord-347946-i6kx3n6m 313 11 , , , cord-347946-i6kx3n6m 313 12 given give VBN cord-347946-i6kx3n6m 313 13 that that DT cord-347946-i6kx3n6m 313 14 cytokine cytokine NN cord-347946-i6kx3n6m 313 15 activation activation NN cord-347946-i6kx3n6m 313 16 suppresses suppress VBZ cord-347946-i6kx3n6m 313 17 sexual sexual JJ cord-347946-i6kx3n6m 313 18 activity activity NN cord-347946-i6kx3n6m 313 19 in in IN cord-347946-i6kx3n6m 313 20 female female NN cord-347946-i6kx3n6m 313 21 , , , cord-347946-i6kx3n6m 313 22 but but CC cord-347946-i6kx3n6m 313 23 not not RB cord-347946-i6kx3n6m 313 24 male male JJ cord-347946-i6kx3n6m 313 25 , , , cord-347946-i6kx3n6m 313 26 rats rat NNS cord-347946-i6kx3n6m 313 27 ( ( -LRB- cord-347946-i6kx3n6m 313 28 Avitsur Avitsur NNP cord-347946-i6kx3n6m 313 29 and and CC cord-347946-i6kx3n6m 313 30 Yirmiya Yirmiya NNP cord-347946-i6kx3n6m 313 31 , , , cord-347946-i6kx3n6m 313 32 1999 1999 CD cord-347946-i6kx3n6m 313 33 ) ) -RRB- cord-347946-i6kx3n6m 313 34 . . . cord-347946-i6kx3n6m 314 1 However however RB cord-347946-i6kx3n6m 314 2 , , , cord-347946-i6kx3n6m 314 3 this this DT cord-347946-i6kx3n6m 314 4 hypothesis hypothesis NN cord-347946-i6kx3n6m 314 5 would would MD cord-347946-i6kx3n6m 314 6 be be VB cord-347946-i6kx3n6m 314 7 strengthened strengthen VBN cord-347946-i6kx3n6m 314 8 by by IN cord-347946-i6kx3n6m 314 9 evidence evidence NN cord-347946-i6kx3n6m 314 10 that that IN cord-347946-i6kx3n6m 314 11 manic manic JJ cord-347946-i6kx3n6m 314 12 behavior behavior NN cord-347946-i6kx3n6m 314 13 itself -PRON- PRP cord-347946-i6kx3n6m 314 14 can can MD cord-347946-i6kx3n6m 314 15 elevate elevate VB cord-347946-i6kx3n6m 314 16 inflammation inflammation NN cord-347946-i6kx3n6m 314 17 and and CC cord-347946-i6kx3n6m 314 18 to to IN cord-347946-i6kx3n6m 314 19 our -PRON- PRP$ cord-347946-i6kx3n6m 314 20 knowledge knowledge NN cord-347946-i6kx3n6m 314 21 this this DT cord-347946-i6kx3n6m 314 22 type type NN cord-347946-i6kx3n6m 314 23 of of IN cord-347946-i6kx3n6m 314 24 causal causal JJ cord-347946-i6kx3n6m 314 25 connection connection NN cord-347946-i6kx3n6m 314 26 has have VBZ cord-347946-i6kx3n6m 314 27 not not RB cord-347946-i6kx3n6m 314 28 been be VBN cord-347946-i6kx3n6m 314 29 investigated investigate VBN cord-347946-i6kx3n6m 314 30 . . . cord-347946-i6kx3n6m 315 1 In in IN cord-347946-i6kx3n6m 315 2 a a DT cord-347946-i6kx3n6m 315 3 previous previous JJ cord-347946-i6kx3n6m 315 4 publication publication NN cord-347946-i6kx3n6m 315 5 we -PRON- PRP cord-347946-i6kx3n6m 315 6 provided provide VBD cord-347946-i6kx3n6m 315 7 an an DT cord-347946-i6kx3n6m 315 8 exhaustive exhaustive JJ cord-347946-i6kx3n6m 315 9 enumeration enumeration NN cord-347946-i6kx3n6m 315 10 of of IN cord-347946-i6kx3n6m 315 11 known know VBN cord-347946-i6kx3n6m 315 12 immune immune NN cord-347946-i6kx3n6m 315 13 and/or and/or CC cord-347946-i6kx3n6m 315 14 pathogen pathogen NN cord-347946-i6kx3n6m 315 15 defense defense NN cord-347946-i6kx3n6m 315 16 functions function NNS cord-347946-i6kx3n6m 315 17 for for IN cord-347946-i6kx3n6m 315 18 the the DT cord-347946-i6kx3n6m 315 19 best well RBS cord-347946-i6kx3n6m 315 20 - - HYPH cord-347946-i6kx3n6m 315 21 supported support VBN cord-347946-i6kx3n6m 315 22 risk risk NN cord-347946-i6kx3n6m 315 23 alleles allele NNS cord-347946-i6kx3n6m 315 24 for for IN cord-347946-i6kx3n6m 315 25 MDD MDD NNP cord-347946-i6kx3n6m 315 26 derived derive VBN cord-347946-i6kx3n6m 315 27 from from IN cord-347946-i6kx3n6m 315 28 genome genome NN cord-347946-i6kx3n6m 315 29 - - HYPH cord-347946-i6kx3n6m 315 30 wide wide JJ cord-347946-i6kx3n6m 315 31 association association NN cord-347946-i6kx3n6m 315 32 studies study NNS cord-347946-i6kx3n6m 315 33 ( ( -LRB- cord-347946-i6kx3n6m 315 34 GWAS GWAS NNP cord-347946-i6kx3n6m 315 35 ) ) -RRB- cord-347946-i6kx3n6m 315 36 and and CC cord-347946-i6kx3n6m 315 37 meta meta NNP cord-347946-i6kx3n6m 315 38 - - HYPH cord-347946-i6kx3n6m 315 39 analyses analysis NNS cord-347946-i6kx3n6m 315 40 of of IN cord-347946-i6kx3n6m 315 41 candidate candidate NN cord-347946-i6kx3n6m 315 42 gene gene NN cord-347946-i6kx3n6m 315 43 studies study NNS cord-347946-i6kx3n6m 315 44 ( ( -LRB- cord-347946-i6kx3n6m 315 45 Raison Raison NNP cord-347946-i6kx3n6m 315 46 and and CC cord-347946-i6kx3n6m 315 47 Miller Miller NNP cord-347946-i6kx3n6m 315 48 , , , cord-347946-i6kx3n6m 315 49 2012 2012 CD cord-347946-i6kx3n6m 315 50 ) ) -RRB- cord-347946-i6kx3n6m 315 51 . . . cord-347946-i6kx3n6m 316 1 These these DT cord-347946-i6kx3n6m 316 2 GWAS GWAS NNP cord-347946-i6kx3n6m 316 3 findings finding NNS cord-347946-i6kx3n6m 316 4 are be VBP cord-347946-i6kx3n6m 316 5 presented present VBN cord-347946-i6kx3n6m 316 6 in in IN cord-347946-i6kx3n6m 316 7 Supplementary Supplementary NNP cord-347946-i6kx3n6m 316 8 Table Table NNP cord-347946-i6kx3n6m 316 9 S3 S3 NNP cord-347946-i6kx3n6m 316 10 . . . cord-347946-i6kx3n6m 317 1 In in IN cord-347946-i6kx3n6m 317 2 the the DT cord-347946-i6kx3n6m 317 3 time time NN cord-347946-i6kx3n6m 317 4 since since IN cord-347946-i6kx3n6m 317 5 our -PRON- PRP$ cord-347946-i6kx3n6m 317 6 prior prior JJ cord-347946-i6kx3n6m 317 7 publication publication NN cord-347946-i6kx3n6m 317 8 , , , cord-347946-i6kx3n6m 317 9 an an DT cord-347946-i6kx3n6m 317 10 additional additional JJ cord-347946-i6kx3n6m 317 11 study study NN cord-347946-i6kx3n6m 317 12 utilized utilize VBN cord-347946-i6kx3n6m 317 13 sparse sparse JJ cord-347946-i6kx3n6m 317 14 wholegenome wholegenome NN cord-347946-i6kx3n6m 317 15 sequencing sequencing NN cord-347946-i6kx3n6m 317 16 in in IN cord-347946-i6kx3n6m 317 17 a a DT cord-347946-i6kx3n6m 317 18 population population NN cord-347946-i6kx3n6m 317 19 of of IN cord-347946-i6kx3n6m 317 20 Han Han NNP cord-347946-i6kx3n6m 317 21 Chinese chinese JJ cord-347946-i6kx3n6m 317 22 females female NNS cord-347946-i6kx3n6m 317 23 to to TO cord-347946-i6kx3n6m 317 24 identify identify VB cord-347946-i6kx3n6m 317 25 and and CC cord-347946-i6kx3n6m 317 26 replicate replicate VB cord-347946-i6kx3n6m 317 27 two two CD cord-347946-i6kx3n6m 317 28 novel novel JJ cord-347946-i6kx3n6m 317 29 depression depression NN cord-347946-i6kx3n6m 317 30 risk risk NN cord-347946-i6kx3n6m 317 31 loci locus NNS cord-347946-i6kx3n6m 317 32 on on IN cord-347946-i6kx3n6m 317 33 chromosome chromosome NN cord-347946-i6kx3n6m 317 34 10 10 CD cord-347946-i6kx3n6m 317 35 , , , cord-347946-i6kx3n6m 317 36 one one CD cord-347946-i6kx3n6m 317 37 5′ 5′ CD cord-347946-i6kx3n6m 317 38 to to IN cord-347946-i6kx3n6m 317 39 the the DT cord-347946-i6kx3n6m 317 40 suirtuin suirtuin NN cord-347946-i6kx3n6m 317 41 1 1 CD cord-347946-i6kx3n6m 317 42 ( ( -LRB- cord-347946-i6kx3n6m 317 43 SIRT1 SIRT1 NNP cord-347946-i6kx3n6m 317 44 ) ) -RRB- cord-347946-i6kx3n6m 317 45 gene gene NN cord-347946-i6kx3n6m 317 46 ( ( -LRB- cord-347946-i6kx3n6m 317 47 rs12415800 rs12415800 NN cord-347946-i6kx3n6m 317 48 ) ) -RRB- cord-347946-i6kx3n6m 317 49 and and CC cord-347946-i6kx3n6m 317 50 one one CD cord-347946-i6kx3n6m 317 51 in in IN cord-347946-i6kx3n6m 317 52 an an DT cord-347946-i6kx3n6m 317 53 intron intron NN cord-347946-i6kx3n6m 317 54 of of IN cord-347946-i6kx3n6m 317 55 the the DT cord-347946-i6kx3n6m 317 56 phospholysine phospholysine NNP cord-347946-i6kx3n6m 317 57 phospho phospho NNP cord-347946-i6kx3n6m 317 58 - - HYPH cord-347946-i6kx3n6m 317 59 histadine histadine NNP cord-347946-i6kx3n6m 317 60 inorganic inorganic JJ cord-347946-i6kx3n6m 317 61 pyrophosphate pyrophosphate NN cord-347946-i6kx3n6m 317 62 phosphatase phosphatase NN cord-347946-i6kx3n6m 317 63 ( ( -LRB- cord-347946-i6kx3n6m 317 64 LHPP LHPP NNP cord-347946-i6kx3n6m 317 65 ) ) -RRB- cord-347946-i6kx3n6m 317 66 gene gene NNP cord-347946-i6kx3n6m 317 67 ( ( -LRB- cord-347946-i6kx3n6m 317 68 consortium consortium NN cord-347946-i6kx3n6m 317 69 C C NNP cord-347946-i6kx3n6m 317 70 ( ( -LRB- cord-347946-i6kx3n6m 317 71 2015 2015 CD cord-347946-i6kx3n6m 317 72 ) ) -RRB- cord-347946-i6kx3n6m 317 73 ) ) -RRB- cord-347946-i6kx3n6m 317 74 . . . cord-347946-i6kx3n6m 318 1 As as IN cord-347946-i6kx3n6m 318 2 with with IN cord-347946-i6kx3n6m 318 3 previously previously RB cord-347946-i6kx3n6m 318 4 identified identify VBN cord-347946-i6kx3n6m 318 5 ' ' '' cord-347946-i6kx3n6m 318 6 genes gene NNS cord-347946-i6kx3n6m 318 7 of of IN cord-347946-i6kx3n6m 318 8 interest interest NN cord-347946-i6kx3n6m 318 9 , , , cord-347946-i6kx3n6m 318 10 ' ' `` cord-347946-i6kx3n6m 318 11 PATHOS pathos NN cord-347946-i6kx3n6m 318 12 - - HYPH cord-347946-i6kx3n6m 318 13 D D NNP cord-347946-i6kx3n6m 318 14 predicts predict VBZ cord-347946-i6kx3n6m 318 15 that that IN cord-347946-i6kx3n6m 318 16 these these DT cord-347946-i6kx3n6m 318 17 genes gene NNS cord-347946-i6kx3n6m 318 18 should should MD cord-347946-i6kx3n6m 318 19 impact impact VB cord-347946-i6kx3n6m 318 20 immune immune JJ cord-347946-i6kx3n6m 318 21 function function NN cord-347946-i6kx3n6m 318 22 in in IN cord-347946-i6kx3n6m 318 23 ways way NNS cord-347946-i6kx3n6m 318 24 that that WDT cord-347946-i6kx3n6m 318 25 provided provide VBD cord-347946-i6kx3n6m 318 26 adaptive adaptive JJ cord-347946-i6kx3n6m 318 27 advantages advantage NNS cord-347946-i6kx3n6m 318 28 for for IN cord-347946-i6kx3n6m 318 29 pathogen pathogen NN cord-347946-i6kx3n6m 318 30 - - HYPH cord-347946-i6kx3n6m 318 31 host host NN cord-347946-i6kx3n6m 318 32 defense defense NN cord-347946-i6kx3n6m 318 33 . . . cord-347946-i6kx3n6m 319 1 In in IN cord-347946-i6kx3n6m 319 2 this this DT cord-347946-i6kx3n6m 319 3 regard regard NN cord-347946-i6kx3n6m 319 4 , , , cord-347946-i6kx3n6m 319 5 nothing nothing NN cord-347946-i6kx3n6m 319 6 is be VBZ cord-347946-i6kx3n6m 319 7 known know VBN cord-347946-i6kx3n6m 319 8 regarding regard VBG cord-347946-i6kx3n6m 319 9 LHPP LHPP NNP cord-347946-i6kx3n6m 319 10 , , , cord-347946-i6kx3n6m 319 11 but but CC cord-347946-i6kx3n6m 319 12 an an DT cord-347946-i6kx3n6m 319 13 extensive extensive JJ cord-347946-i6kx3n6m 319 14 database database NN cord-347946-i6kx3n6m 319 15 attests attest VBZ cord-347946-i6kx3n6m 319 16 to to IN cord-347946-i6kx3n6m 319 17 multiple multiple JJ cord-347946-i6kx3n6m 319 18 immune immune JJ cord-347946-i6kx3n6m 319 19 functions function NNS cord-347946-i6kx3n6m 319 20 of of IN cord-347946-i6kx3n6m 319 21 sirtuin sirtuin NNP cord-347946-i6kx3n6m 319 22 1 1 CD cord-347946-i6kx3n6m 319 23 , , , cord-347946-i6kx3n6m 319 24 a a DT cord-347946-i6kx3n6m 319 25 class class NN cord-347946-i6kx3n6m 319 26 III iii CD cord-347946-i6kx3n6m 319 27 histone histone NN cord-347946-i6kx3n6m 319 28 deacetylase deacetylase NN cord-347946-i6kx3n6m 319 29 enzyme enzyme NN cord-347946-i6kx3n6m 319 30 that that WDT cord-347946-i6kx3n6m 319 31 serves serve VBZ cord-347946-i6kx3n6m 319 32 as as IN cord-347946-i6kx3n6m 319 33 an an DT cord-347946-i6kx3n6m 319 34 important important JJ cord-347946-i6kx3n6m 319 35 sensor sensor NN cord-347946-i6kx3n6m 319 36 of of IN cord-347946-i6kx3n6m 319 37 cellular cellular JJ cord-347946-i6kx3n6m 319 38 energy energy NN cord-347946-i6kx3n6m 319 39 and and CC cord-347946-i6kx3n6m 319 40 redox redox NNP cord-347946-i6kx3n6m 319 41 states state NNS cord-347946-i6kx3n6m 319 42 ( ( -LRB- cord-347946-i6kx3n6m 319 43 Supplementary Supplementary NNP cord-347946-i6kx3n6m 319 44 Table Table NNP cord-347946-i6kx3n6m 319 45 S3 s3 NN cord-347946-i6kx3n6m 319 46 ; ; : cord-347946-i6kx3n6m 319 47 Michan Michan NNP cord-347946-i6kx3n6m 319 48 and and CC cord-347946-i6kx3n6m 319 49 Sinclair Sinclair NNP cord-347946-i6kx3n6m 319 50 , , , cord-347946-i6kx3n6m 319 51 2007 2007 CD cord-347946-i6kx3n6m 319 52 ) ) -RRB- cord-347946-i6kx3n6m 319 53 . . . cord-347946-i6kx3n6m 320 1 In in IN cord-347946-i6kx3n6m 320 2 particular particular JJ cord-347946-i6kx3n6m 320 3 , , , cord-347946-i6kx3n6m 320 4 sirtuin sirtuin NNP cord-347946-i6kx3n6m 320 5 1 1 CD cord-347946-i6kx3n6m 320 6 has have VBZ cord-347946-i6kx3n6m 320 7 been be VBN cord-347946-i6kx3n6m 320 8 shown show VBN cord-347946-i6kx3n6m 320 9 via via IN cord-347946-i6kx3n6m 320 10 epigenetic epigenetic JJ cord-347946-i6kx3n6m 320 11 mechanisms mechanism NNS cord-347946-i6kx3n6m 320 12 to to TO cord-347946-i6kx3n6m 320 13 have have VB cord-347946-i6kx3n6m 320 14 a a DT cord-347946-i6kx3n6m 320 15 key key JJ cord-347946-i6kx3n6m 320 16 role role NN cord-347946-i6kx3n6m 320 17 in in IN cord-347946-i6kx3n6m 320 18 limiting limit VBG cord-347946-i6kx3n6m 320 19 the the DT cord-347946-i6kx3n6m 320 20 extent extent NN cord-347946-i6kx3n6m 320 21 and and CC cord-347946-i6kx3n6m 320 22 duration duration NN cord-347946-i6kx3n6m 320 23 of of IN cord-347946-i6kx3n6m 320 24 acute acute JJ cord-347946-i6kx3n6m 320 25 inflammation inflammation NN cord-347946-i6kx3n6m 320 26 by by IN cord-347946-i6kx3n6m 320 27 promoting promote VBG cord-347946-i6kx3n6m 320 28 a a DT cord-347946-i6kx3n6m 320 29 shift shift NN cord-347946-i6kx3n6m 320 30 from from IN cord-347946-i6kx3n6m 320 31 inflammation inflammation NN cord-347946-i6kx3n6m 320 32 - - HYPH cord-347946-i6kx3n6m 320 33 driven drive VBN cord-347946-i6kx3n6m 320 34 glycolytic glycolytic JJ cord-347946-i6kx3n6m 320 35 activity activity NN cord-347946-i6kx3n6m 320 36 to to IN cord-347946-i6kx3n6m 320 37 ' ' '' cord-347946-i6kx3n6m 320 38 adaptation adaptation NN cord-347946-i6kx3n6m 320 39 - - HYPH cord-347946-i6kx3n6m 320 40 phase phase NN cord-347946-i6kx3n6m 320 41 ' ' `` cord-347946-i6kx3n6m 320 42 fatty fatty JJ cord-347946-i6kx3n6m 320 43 acid acid NN cord-347946-i6kx3n6m 320 44 metabolism metabolism NN cord-347946-i6kx3n6m 320 45 . . . cord-347946-i6kx3n6m 321 1 Sirtuin Sirtuin NNP cord-347946-i6kx3n6m 321 2 1 1 CD cord-347946-i6kx3n6m 321 3 suppresses suppress VBZ cord-347946-i6kx3n6m 321 4 nuclear nuclear JJ cord-347946-i6kx3n6m 321 5 factorkappa factorkappa NN cord-347946-i6kx3n6m 321 6 B B NNP cord-347946-i6kx3n6m 321 7 RelA RelA NNP cord-347946-i6kx3n6m 321 8 / / SYM cord-347946-i6kx3n6m 321 9 p65 p65 NN cord-347946-i6kx3n6m 321 10 activity activity NN cord-347946-i6kx3n6m 321 11 , , , cord-347946-i6kx3n6m 321 12 represses repress VBZ cord-347946-i6kx3n6m 321 13 cyclooxygenase cyclooxygenase JJ cord-347946-i6kx3n6m 321 14 2 2 CD cord-347946-i6kx3n6m 321 15 gene gene NN cord-347946-i6kx3n6m 321 16 expression expression NN cord-347946-i6kx3n6m 321 17 ( ( -LRB- cord-347946-i6kx3n6m 321 18 Zhang Zhang NNP cord-347946-i6kx3n6m 321 19 et et NNP cord-347946-i6kx3n6m 321 20 al al NNP cord-347946-i6kx3n6m 321 21 , , , cord-347946-i6kx3n6m 321 22 2010b 2010b CD cord-347946-i6kx3n6m 321 23 ) ) -RRB- cord-347946-i6kx3n6m 321 24 , , , cord-347946-i6kx3n6m 321 25 and and CC cord-347946-i6kx3n6m 321 26 induces induce VBZ cord-347946-i6kx3n6m 321 27 gene gene NN cord-347946-i6kx3n6m 321 28 silencing silence VBG cord-347946-i6kx3n6m 321 29 facultative facultative JJ cord-347946-i6kx3n6m 321 30 heterochomatin heterochomatin NN cord-347946-i6kx3n6m 321 31 formation formation NN cord-347946-i6kx3n6m 321 32 at at IN cord-347946-i6kx3n6m 321 33 the the DT cord-347946-i6kx3n6m 321 34 promotors promotor NNS cord-347946-i6kx3n6m 321 35 of of IN cord-347946-i6kx3n6m 321 36 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 321 37 genes gene NNS cord-347946-i6kx3n6m 321 38 , , , cord-347946-i6kx3n6m 321 39 including include VBG cord-347946-i6kx3n6m 321 40 TNF TNF NNP cord-347946-i6kx3n6m 321 41 and and CC cord-347946-i6kx3n6m 321 42 IL-1-β IL-1-β NNP cord-347946-i6kx3n6m 321 43 , , , cord-347946-i6kx3n6m 321 44 as as RB cord-347946-i6kx3n6m 321 45 well well RB cord-347946-i6kx3n6m 321 46 as as IN cord-347946-i6kx3n6m 321 47 the the DT cord-347946-i6kx3n6m 321 48 promotor promotor NN cord-347946-i6kx3n6m 321 49 for for IN cord-347946-i6kx3n6m 321 50 hypoxia hypoxia NN cord-347946-i6kx3n6m 321 51 - - HYPH cord-347946-i6kx3n6m 321 52 inducible inducible JJ cord-347946-i6kx3n6m 321 53 factor-1-α factor-1-α NNS cord-347946-i6kx3n6m 321 54 , , , cord-347946-i6kx3n6m 321 55 a a DT cord-347946-i6kx3n6m 321 56 signaling signal VBG cord-347946-i6kx3n6m 321 57 factor factor NN cord-347946-i6kx3n6m 321 58 important important JJ cord-347946-i6kx3n6m 321 59 for for IN cord-347946-i6kx3n6m 321 60 maintenance maintenance NN cord-347946-i6kx3n6m 321 61 of of IN cord-347946-i6kx3n6m 321 62 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 321 63 glycolytic glycolytic JJ cord-347946-i6kx3n6m 321 64 activity activity NN cord-347946-i6kx3n6m 322 1 ( ( -LRB- cord-347946-i6kx3n6m 322 2 Vachharajani Vachharajani NNP cord-347946-i6kx3n6m 322 3 et et NNP cord-347946-i6kx3n6m 322 4 al al NNP cord-347946-i6kx3n6m 322 5 , , , cord-347946-i6kx3n6m 322 6 2016 2016 CD cord-347946-i6kx3n6m 322 7 ) ) -RRB- cord-347946-i6kx3n6m 322 8 . . . cord-347946-i6kx3n6m 323 1 In in IN cord-347946-i6kx3n6m 323 2 addition addition NN cord-347946-i6kx3n6m 323 3 , , , cord-347946-i6kx3n6m 323 4 sirtuin sirtuin NNP cord-347946-i6kx3n6m 323 5 1 1 CD cord-347946-i6kx3n6m 323 6 , , , cord-347946-i6kx3n6m 323 7 in in IN cord-347946-i6kx3n6m 323 8 dependence dependence NN cord-347946-i6kx3n6m 323 9 on on IN cord-347946-i6kx3n6m 323 10 NAD+ NAD+ NNP cord-347946-i6kx3n6m 323 11 , , , cord-347946-i6kx3n6m 323 12 increases increase VBZ cord-347946-i6kx3n6m 323 13 levels level NNS cord-347946-i6kx3n6m 323 14 of of IN cord-347946-i6kx3n6m 323 15 peroxisome peroxisome NN cord-347946-i6kx3n6m 323 16 proliferator proliferator NN cord-347946-i6kx3n6m 323 17 - - HYPH cord-347946-i6kx3n6m 323 18 activated activate VBN cord-347946-i6kx3n6m 323 19 receptor receptor NN cord-347946-i6kx3n6m 323 20 gamma gamma NN cord-347946-i6kx3n6m 323 21 coactivator coactivator NN cord-347946-i6kx3n6m 323 22 1 1 CD cord-347946-i6kx3n6m 324 1 ( ( -LRB- cord-347946-i6kx3n6m 324 2 PCG-1)-α PCG-1)-α NNP cord-347946-i6kx3n6m 324 3 and and CC cord-347946-i6kx3n6m 324 4 β β NNP cord-347946-i6kx3n6m 324 5 , , , cord-347946-i6kx3n6m 324 6 which which WDT cord-347946-i6kx3n6m 324 7 promotes promote VBZ cord-347946-i6kx3n6m 324 8 the the DT cord-347946-i6kx3n6m 324 9 fatty fatty JJ cord-347946-i6kx3n6m 324 10 acid acid NN cord-347946-i6kx3n6m 324 11 metabolism metabolism NN cord-347946-i6kx3n6m 324 12 essential essential JJ cord-347946-i6kx3n6m 324 13 for for IN cord-347946-i6kx3n6m 324 14 resolution resolution NN cord-347946-i6kx3n6m 324 15 of of IN cord-347946-i6kx3n6m 324 16 the the DT cord-347946-i6kx3n6m 324 17 inflammatory inflammatory JJ cord-347946-i6kx3n6m 324 18 response response NN cord-347946-i6kx3n6m 324 19 ( ( -LRB- cord-347946-i6kx3n6m 324 20 Fernandez Fernandez NNP cord-347946-i6kx3n6m 324 21 - - HYPH cord-347946-i6kx3n6m 324 22 Marcos Marcos NNP cord-347946-i6kx3n6m 324 23 and and CC cord-347946-i6kx3n6m 324 24 Auwerx Auwerx NNP cord-347946-i6kx3n6m 324 25 , , , cord-347946-i6kx3n6m 324 26 2011 2011 CD cord-347946-i6kx3n6m 324 27 ) ) -RRB- cord-347946-i6kx3n6m 324 28 . . . cord-347946-i6kx3n6m 325 1 The the DT cord-347946-i6kx3n6m 325 2 end end NN cord-347946-i6kx3n6m 325 3 result result NN cord-347946-i6kx3n6m 325 4 of of IN cord-347946-i6kx3n6m 325 5 these these DT cord-347946-i6kx3n6m 325 6 activities activity NNS cord-347946-i6kx3n6m 325 7 is be VBZ cord-347946-i6kx3n6m 325 8 that that IN cord-347946-i6kx3n6m 325 9 sirtuin sirtuin NNP cord-347946-i6kx3n6m 325 10 1 1 CD cord-347946-i6kx3n6m 325 11 inhibits inhibit VBZ cord-347946-i6kx3n6m 325 12 the the DT cord-347946-i6kx3n6m 325 13 transformation transformation NN cord-347946-i6kx3n6m 325 14 of of IN cord-347946-i6kx3n6m 325 15 monocytes monocyte NNS cord-347946-i6kx3n6m 325 16 to to IN cord-347946-i6kx3n6m 325 17 macrophages macrophage NNS cord-347946-i6kx3n6m 325 18 and and CC cord-347946-i6kx3n6m 325 19 promotes promote VBZ cord-347946-i6kx3n6m 325 20 anti anti JJ cord-347946-i6kx3n6m 325 21 - - JJ cord-347946-i6kx3n6m 325 22 inflammatory inflammatory JJ cord-347946-i6kx3n6m 325 23 M2 M2 NNP cord-347946-i6kx3n6m 325 24 macrophages macrophage NNS cord-347946-i6kx3n6m 325 25 and and CC cord-347946-i6kx3n6m 325 26 regulatory regulatory JJ cord-347946-i6kx3n6m 325 27 T t NN cord-347946-i6kx3n6m 325 28 cells cell NNS cord-347946-i6kx3n6m 325 29 ( ( -LRB- cord-347946-i6kx3n6m 325 30 Treg Treg NNP cord-347946-i6kx3n6m 325 31 ) ) -RRB- cord-347946-i6kx3n6m 325 32 at at IN cord-347946-i6kx3n6m 325 33 the the DT cord-347946-i6kx3n6m 325 34 expense expense NN cord-347946-i6kx3n6m 325 35 of of IN cord-347946-i6kx3n6m 325 36 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 325 37 M1-type M1-type NNS cord-347946-i6kx3n6m 325 38 macrophages macrophage NNS cord-347946-i6kx3n6m 325 39 and and CC cord-347946-i6kx3n6m 325 40 effector effector VB cord-347946-i6kx3n6m 325 41 T t NN cord-347946-i6kx3n6m 325 42 cells cell NNS cord-347946-i6kx3n6m 326 1 ( ( -LRB- cord-347946-i6kx3n6m 326 2 Liu Liu NNP cord-347946-i6kx3n6m 326 3 et et NNP cord-347946-i6kx3n6m 326 4 al al NNP cord-347946-i6kx3n6m 326 5 , , , cord-347946-i6kx3n6m 326 6 2012a 2012a CD cord-347946-i6kx3n6m 326 7 ; ; : cord-347946-i6kx3n6m 326 8 Park Park NNP cord-347946-i6kx3n6m 326 9 et et FW cord-347946-i6kx3n6m 326 10 al al NNP cord-347946-i6kx3n6m 326 11 , , , cord-347946-i6kx3n6m 326 12 2016 2016 CD cord-347946-i6kx3n6m 326 13 ) ) -RRB- cord-347946-i6kx3n6m 326 14 . . . cord-347946-i6kx3n6m 327 1 However however RB cord-347946-i6kx3n6m 327 2 , , , cord-347946-i6kx3n6m 327 3 conflicting conflict VBG cord-347946-i6kx3n6m 327 4 data datum NNS cord-347946-i6kx3n6m 327 5 suggest suggest VBP cord-347946-i6kx3n6m 327 6 that that IN cord-347946-i6kx3n6m 327 7 in in IN cord-347946-i6kx3n6m 327 8 at at IN cord-347946-i6kx3n6m 327 9 least least JJS cord-347946-i6kx3n6m 327 10 some some DT cord-347946-i6kx3n6m 327 11 contexts contexts NN cord-347946-i6kx3n6m 327 12 sirtuin sirtuin NNP cord-347946-i6kx3n6m 327 13 1 1 CD cord-347946-i6kx3n6m 327 14 may may MD cord-347946-i6kx3n6m 327 15 have have VB cord-347946-i6kx3n6m 327 16 inflammatory inflammatory JJ cord-347946-i6kx3n6m 327 17 and and CC cord-347946-i6kx3n6m 327 18 adaptive adaptive JJ cord-347946-i6kx3n6m 327 19 immune immune JJ cord-347946-i6kx3n6m 327 20 stimulating stimulate VBG cord-347946-i6kx3n6m 327 21 effects effect NNS cord-347946-i6kx3n6m 327 22 . . . cord-347946-i6kx3n6m 328 1 For for IN cord-347946-i6kx3n6m 328 2 example example NN cord-347946-i6kx3n6m 328 3 , , , cord-347946-i6kx3n6m 328 4 sirtuin sirtuin NNP cord-347946-i6kx3n6m 328 5 1 1 CD cord-347946-i6kx3n6m 328 6 inhibition inhibition NN cord-347946-i6kx3n6m 328 7 has have VBZ cord-347946-i6kx3n6m 328 8 been be VBN cord-347946-i6kx3n6m 328 9 reported report VBN cord-347946-i6kx3n6m 328 10 to to TO cord-347946-i6kx3n6m 328 11 stimulate stimulate VB cord-347946-i6kx3n6m 328 12 Foxp3 foxp3 JJ cord-347946-i6kx3n6m 328 13 expression expression NN cord-347946-i6kx3n6m 328 14 in in IN cord-347946-i6kx3n6m 328 15 Treg Treg NNP cord-347946-i6kx3n6m 328 16 ( ( -LRB- cord-347946-i6kx3n6m 328 17 Akimova Akimova NNP cord-347946-i6kx3n6m 328 18 et et NNP cord-347946-i6kx3n6m 328 19 al al NNP cord-347946-i6kx3n6m 328 20 , , , cord-347946-i6kx3n6m 328 21 2014 2014 CD cord-347946-i6kx3n6m 328 22 ) ) -RRB- cord-347946-i6kx3n6m 328 23 . . . cord-347946-i6kx3n6m 329 1 Despite despite IN cord-347946-i6kx3n6m 329 2 these these DT cord-347946-i6kx3n6m 329 3 complexities complexity NNS cord-347946-i6kx3n6m 329 4 , , , cord-347946-i6kx3n6m 329 5 evidence evidence NN cord-347946-i6kx3n6m 329 6 of of IN cord-347946-i6kx3n6m 329 7 diminished diminished JJ cord-347946-i6kx3n6m 329 8 sirtuin sirtuin NNP cord-347946-i6kx3n6m 329 9 1 1 CD cord-347946-i6kx3n6m 329 10 activity activity NN cord-347946-i6kx3n6m 329 11 in in IN cord-347946-i6kx3n6m 329 12 medical medical JJ cord-347946-i6kx3n6m 329 13 conditions condition NNS cord-347946-i6kx3n6m 329 14 characterized characterize VBN cord-347946-i6kx3n6m 329 15 by by IN cord-347946-i6kx3n6m 329 16 chronic chronic JJ cord-347946-i6kx3n6m 329 17 inflammation inflammation NN cord-347946-i6kx3n6m 329 18 suggest suggest VBP cord-347946-i6kx3n6m 329 19 that that IN cord-347946-i6kx3n6m 329 20 its -PRON- PRP$ cord-347946-i6kx3n6m 329 21 function function NN cord-347946-i6kx3n6m 329 22 might may MD cord-347946-i6kx3n6m 329 23 also also RB cord-347946-i6kx3n6m 329 24 be be VB cord-347946-i6kx3n6m 329 25 reduced reduce VBN cord-347946-i6kx3n6m 329 26 in in IN cord-347946-i6kx3n6m 329 27 MDD MDD NNP cord-347946-i6kx3n6m 329 28 , , , cord-347946-i6kx3n6m 329 29 especially especially RB cord-347946-i6kx3n6m 329 30 in in IN cord-347946-i6kx3n6m 329 31 patients patient NNS cord-347946-i6kx3n6m 329 32 with with IN cord-347946-i6kx3n6m 329 33 elevated elevated JJ cord-347946-i6kx3n6m 329 34 peripheral peripheral JJ cord-347946-i6kx3n6m 329 35 inflammatory inflammatory JJ cord-347946-i6kx3n6m 329 36 biomarkers biomarker NNS cord-347946-i6kx3n6m 329 37 . . . cord-347946-i6kx3n6m 330 1 However however RB cord-347946-i6kx3n6m 330 2 , , , cord-347946-i6kx3n6m 330 3 to to IN cord-347946-i6kx3n6m 330 4 our -PRON- PRP$ cord-347946-i6kx3n6m 330 5 knowledge knowledge NN cord-347946-i6kx3n6m 330 6 , , , cord-347946-i6kx3n6m 330 7 no no DT cord-347946-i6kx3n6m 330 8 data datum NNS cord-347946-i6kx3n6m 330 9 are be VBP cord-347946-i6kx3n6m 330 10 available available JJ cord-347946-i6kx3n6m 330 11 to to TO cord-347946-i6kx3n6m 330 12 support support VB cord-347946-i6kx3n6m 330 13 or or CC cord-347946-i6kx3n6m 330 14 disprove disprove VB cord-347946-i6kx3n6m 330 15 this this DT cord-347946-i6kx3n6m 330 16 idea idea NN cord-347946-i6kx3n6m 330 17 . . . cord-347946-i6kx3n6m 331 1 Similarly similarly RB cord-347946-i6kx3n6m 331 2 , , , cord-347946-i6kx3n6m 331 3 given give VBN cord-347946-i6kx3n6m 331 4 the the DT cord-347946-i6kx3n6m 331 5 association association NN cord-347946-i6kx3n6m 331 6 of of IN cord-347946-i6kx3n6m 331 7 MDD MDD NNP cord-347946-i6kx3n6m 331 8 with with IN cord-347946-i6kx3n6m 331 9 chronic chronic JJ cord-347946-i6kx3n6m 331 10 inflammation inflammation NN cord-347946-i6kx3n6m 331 11 , , , cord-347946-i6kx3n6m 331 12 one one PRP cord-347946-i6kx3n6m 331 13 would would MD cord-347946-i6kx3n6m 331 14 predict predict VB cord-347946-i6kx3n6m 331 15 that that IN cord-347946-i6kx3n6m 331 16 the the DT cord-347946-i6kx3n6m 331 17 depression depression NN cord-347946-i6kx3n6m 331 18 risk risk NN cord-347946-i6kx3n6m 331 19 allele allele NN cord-347946-i6kx3n6m 331 20 near near IN cord-347946-i6kx3n6m 331 21 the the DT cord-347946-i6kx3n6m 331 22 SIRT1 sirt1 NN cord-347946-i6kx3n6m 331 23 gene gene NN cord-347946-i6kx3n6m 331 24 should should MD cord-347946-i6kx3n6m 331 25 reduce reduce VB cord-347946-i6kx3n6m 331 26 sirtuin sirtuin NNP cord-347946-i6kx3n6m 331 27 1 1 CD cord-347946-i6kx3n6m 331 28 activity activity NN cord-347946-i6kx3n6m 331 29 , , , cord-347946-i6kx3n6m 331 30 if if IN cord-347946-i6kx3n6m 331 31 it -PRON- PRP cord-347946-i6kx3n6m 331 32 is be VBZ cord-347946-i6kx3n6m 331 33 found find VBN cord-347946-i6kx3n6m 331 34 to to TO cord-347946-i6kx3n6m 331 35 have have VB cord-347946-i6kx3n6m 331 36 a a DT cord-347946-i6kx3n6m 331 37 functional functional JJ cord-347946-i6kx3n6m 331 38 effect effect NN cord-347946-i6kx3n6m 331 39 , , , cord-347946-i6kx3n6m 331 40 which which WDT cord-347946-i6kx3n6m 331 41 is be VBZ cord-347946-i6kx3n6m 331 42 currently currently RB cord-347946-i6kx3n6m 331 43 unknown unknown JJ cord-347946-i6kx3n6m 331 44 . . . cord-347946-i6kx3n6m 332 1 However however RB cord-347946-i6kx3n6m 332 2 , , , cord-347946-i6kx3n6m 332 3 these these DT cord-347946-i6kx3n6m 332 4 predictions prediction NNS cord-347946-i6kx3n6m 332 5 should should MD cord-347946-i6kx3n6m 332 6 be be VB cord-347946-i6kx3n6m 332 7 tempered temper VBN cord-347946-i6kx3n6m 332 8 by by IN cord-347946-i6kx3n6m 332 9 findings finding NNS cord-347946-i6kx3n6m 332 10 suggesting suggest VBG cord-347946-i6kx3n6m 332 11 a a DT cord-347946-i6kx3n6m 332 12 complex complex JJ cord-347946-i6kx3n6m 332 13 and and CC cord-347946-i6kx3n6m 332 14 contradictory contradictory JJ cord-347946-i6kx3n6m 332 15 role role NN cord-347946-i6kx3n6m 332 16 for for IN cord-347946-i6kx3n6m 332 17 sirtuin sirtuin NNP cord-347946-i6kx3n6m 332 18 1 1 CD cord-347946-i6kx3n6m 332 19 in in IN cord-347946-i6kx3n6m 332 20 pathogen pathogen NN cord-347946-i6kx3n6m 332 21 defense defense NN cord-347946-i6kx3n6m 332 22 . . . cord-347946-i6kx3n6m 333 1 In in IN cord-347946-i6kx3n6m 333 2 certain certain JJ cord-347946-i6kx3n6m 333 3 contexts context NNS cord-347946-i6kx3n6m 333 4 , , , cord-347946-i6kx3n6m 333 5 such such JJ cord-347946-i6kx3n6m 333 6 as as IN cord-347946-i6kx3n6m 333 7 the the DT cord-347946-i6kx3n6m 333 8 hypoinflammatory hypoinflammatory NN cord-347946-i6kx3n6m 333 9 phase phase NN cord-347946-i6kx3n6m 333 10 of of IN cord-347946-i6kx3n6m 333 11 sepsis sepsis NN cord-347946-i6kx3n6m 333 12 , , , cord-347946-i6kx3n6m 333 13 sirtuin sirtuin NNP cord-347946-i6kx3n6m 333 14 1 1 CD cord-347946-i6kx3n6m 333 15 blockade blockade NN cord-347946-i6kx3n6m 333 16 has have VBZ cord-347946-i6kx3n6m 333 17 been be VBN cord-347946-i6kx3n6m 333 18 reported report VBN cord-347946-i6kx3n6m 333 19 to to TO cord-347946-i6kx3n6m 333 20 reduce reduce VB cord-347946-i6kx3n6m 333 21 bacterial bacterial JJ cord-347946-i6kx3n6m 333 22 load load NN cord-347946-i6kx3n6m 333 23 and and CC cord-347946-i6kx3n6m 333 24 enhance enhance VB cord-347946-i6kx3n6m 333 25 survival survival NN cord-347946-i6kx3n6m 333 26 . . . cord-347946-i6kx3n6m 334 1 Sirtuin Sirtuin NNP cord-347946-i6kx3n6m 334 2 1 1 CD cord-347946-i6kx3n6m 334 3 blockade blockade NN cord-347946-i6kx3n6m 334 4 has have VBZ cord-347946-i6kx3n6m 334 5 also also RB cord-347946-i6kx3n6m 334 6 been be VBN cord-347946-i6kx3n6m 334 7 shown show VBN cord-347946-i6kx3n6m 334 8 to to TO cord-347946-i6kx3n6m 334 9 inhibit inhibit VB cord-347946-i6kx3n6m 334 10 hepatitis hepatitis NN cord-347946-i6kx3n6m 334 11 B b NN cord-347946-i6kx3n6m 334 12 replication replication NN cord-347946-i6kx3n6m 334 13 in in IN cord-347946-i6kx3n6m 334 14 hepatocytes hepatocyte NNS cord-347946-i6kx3n6m 334 15 ( ( -LRB- cord-347946-i6kx3n6m 334 16 Ren Ren NNP cord-347946-i6kx3n6m 334 17 et et NNP cord-347946-i6kx3n6m 334 18 al al NNP cord-347946-i6kx3n6m 334 19 , , , cord-347946-i6kx3n6m 334 20 2014 2014 CD cord-347946-i6kx3n6m 334 21 ) ) -RRB- cord-347946-i6kx3n6m 334 22 . . . cord-347946-i6kx3n6m 335 1 Similarly similarly RB cord-347946-i6kx3n6m 335 2 , , , cord-347946-i6kx3n6m 335 3 sirtuin sirtuin NN cord-347946-i6kx3n6m 335 4 - - HYPH cord-347946-i6kx3n6m 335 5 deficient deficient JJ cord-347946-i6kx3n6m 335 6 mice mouse NNS cord-347946-i6kx3n6m 335 7 have have VBP cord-347946-i6kx3n6m 335 8 been be VBN cord-347946-i6kx3n6m 335 9 shown show VBN cord-347946-i6kx3n6m 335 10 to to TO cord-347946-i6kx3n6m 335 11 demonstrate demonstrate VB cord-347946-i6kx3n6m 335 12 improved improve VBN cord-347946-i6kx3n6m 335 13 intestinal intestinal JJ cord-347946-i6kx3n6m 335 14 anti anti JJ cord-347946-i6kx3n6m 335 15 - - JJ cord-347946-i6kx3n6m 335 16 bacterial bacterial JJ cord-347946-i6kx3n6m 335 17 defense defense NN cord-347946-i6kx3n6m 335 18 mechanisms mechanism NNS cord-347946-i6kx3n6m 335 19 ( ( -LRB- cord-347946-i6kx3n6m 335 20 Lo Lo NNP cord-347946-i6kx3n6m 335 21 Sasso Sasso NNP cord-347946-i6kx3n6m 335 22 et et FW cord-347946-i6kx3n6m 335 23 al al NNP cord-347946-i6kx3n6m 335 24 , , , cord-347946-i6kx3n6m 335 25 2014 2014 CD cord-347946-i6kx3n6m 335 26 ) ) -RRB- cord-347946-i6kx3n6m 335 27 . . . cord-347946-i6kx3n6m 336 1 On on IN cord-347946-i6kx3n6m 336 2 the the DT cord-347946-i6kx3n6m 336 3 other other JJ cord-347946-i6kx3n6m 336 4 hand hand NN cord-347946-i6kx3n6m 336 5 , , , cord-347946-i6kx3n6m 336 6 the the DT cord-347946-i6kx3n6m 336 7 use use NN cord-347946-i6kx3n6m 336 8 of of IN cord-347946-i6kx3n6m 336 9 celecoxib celecoxib NNS cord-347946-i6kx3n6m 336 10 to to TO cord-347946-i6kx3n6m 336 11 stimulate stimulate VB cord-347946-i6kx3n6m 336 12 sirtuin sirtuin NNP cord-347946-i6kx3n6m 336 13 1 1 CD cord-347946-i6kx3n6m 336 14 within within IN cord-347946-i6kx3n6m 336 15 macrophages macrophage NNS cord-347946-i6kx3n6m 336 16 resulted result VBD cord-347946-i6kx3n6m 336 17 in in IN cord-347946-i6kx3n6m 336 18 an an DT cord-347946-i6kx3n6m 336 19 enhanced enhanced JJ cord-347946-i6kx3n6m 336 20 ability ability NN cord-347946-i6kx3n6m 336 21 of of IN cord-347946-i6kx3n6m 336 22 ampicillin ampicillin NN cord-347946-i6kx3n6m 336 23 to to TO cord-347946-i6kx3n6m 336 24 clear clear VB cord-347946-i6kx3n6m 336 25 Staphylococcus Staphylococcus NNP cord-347946-i6kx3n6m 336 26 aureus aureus NN cord-347946-i6kx3n6m 336 27 from from IN cord-347946-i6kx3n6m 336 28 these these DT cord-347946-i6kx3n6m 336 29 cells cell NNS cord-347946-i6kx3n6m 336 30 ( ( -LRB- cord-347946-i6kx3n6m 336 31 Annamanedi Annamanedi NNP cord-347946-i6kx3n6m 336 32 and and CC cord-347946-i6kx3n6m 336 33 Kalle Kalle NNP cord-347946-i6kx3n6m 336 34 , , , cord-347946-i6kx3n6m 336 35 2014 2014 CD cord-347946-i6kx3n6m 336 36 ) ) -RRB- cord-347946-i6kx3n6m 336 37 , , , cord-347946-i6kx3n6m 336 38 consistent consistent JJ cord-347946-i6kx3n6m 336 39 with with IN cord-347946-i6kx3n6m 336 40 the the DT cord-347946-i6kx3n6m 336 41 observation observation NN cord-347946-i6kx3n6m 336 42 that that IN cord-347946-i6kx3n6m 336 43 low low JJ cord-347946-i6kx3n6m 336 44 levels level NNS cord-347946-i6kx3n6m 336 45 of of IN cord-347946-i6kx3n6m 336 46 sirtuin sirtuin NNP cord-347946-i6kx3n6m 336 47 1 1 CD cord-347946-i6kx3n6m 336 48 within within IN cord-347946-i6kx3n6m 336 49 macrophages macrophages NN cord-347946-i6kx3n6m 336 50 associates associate NNS cord-347946-i6kx3n6m 336 51 with with IN cord-347946-i6kx3n6m 336 52 bacterial bacterial JJ cord-347946-i6kx3n6m 336 53 infection infection NN cord-347946-i6kx3n6m 336 54 in in IN cord-347946-i6kx3n6m 336 55 these these DT cord-347946-i6kx3n6m 336 56 cells cell NNS cord-347946-i6kx3n6m 337 1 ( ( -LRB- cord-347946-i6kx3n6m 337 2 Zhang Zhang NNP cord-347946-i6kx3n6m 337 3 et et NNP cord-347946-i6kx3n6m 337 4 al al NNP cord-347946-i6kx3n6m 337 5 , , , cord-347946-i6kx3n6m 337 6 2010a 2010a CD cord-347946-i6kx3n6m 338 1 ( ( -LRB- cord-347946-i6kx3n6m 338 2 Zhang Zhang NNP cord-347946-i6kx3n6m 338 3 et et NNP cord-347946-i6kx3n6m 338 4 al al NNP cord-347946-i6kx3n6m 338 5 , , , cord-347946-i6kx3n6m 338 6 , , , cord-347946-i6kx3n6m 338 7 2010b 2010b CD cord-347946-i6kx3n6m 338 8 . . . cord-347946-i6kx3n6m 339 1 Sirtuin Sirtuin NNP cord-347946-i6kx3n6m 339 2 1 1 CD cord-347946-i6kx3n6m 339 3 also also RB cord-347946-i6kx3n6m 339 4 appears appear VBZ cord-347946-i6kx3n6m 339 5 to to TO cord-347946-i6kx3n6m 339 6 be be VB cord-347946-i6kx3n6m 339 7 essential essential JJ cord-347946-i6kx3n6m 339 8 for for IN cord-347946-i6kx3n6m 339 9 optimal optimal JJ cord-347946-i6kx3n6m 339 10 immune immune JJ cord-347946-i6kx3n6m 339 11 clearance clearance NN cord-347946-i6kx3n6m 339 12 of of IN cord-347946-i6kx3n6m 339 13 respiratory respiratory JJ cord-347946-i6kx3n6m 339 14 syncytial syncytial JJ cord-347946-i6kx3n6m 339 15 virus virus NN cord-347946-i6kx3n6m 339 16 and and CC cord-347946-i6kx3n6m 339 17 has have VBZ cord-347946-i6kx3n6m 339 18 been be VBN cord-347946-i6kx3n6m 339 19 shown show VBN cord-347946-i6kx3n6m 339 20 to to TO cord-347946-i6kx3n6m 339 21 suppress suppress VB cord-347946-i6kx3n6m 339 22 human human JJ cord-347946-i6kx3n6m 339 23 T t NN cord-347946-i6kx3n6m 339 24 - - HYPH cord-347946-i6kx3n6m 339 25 cell cell NN cord-347946-i6kx3n6m 339 26 leukemia leukemia NN cord-347946-i6kx3n6m 339 27 virus virus NN cord-347946-i6kx3n6m 339 28 type type NN cord-347946-i6kx3n6m 339 29 1 1 CD cord-347946-i6kx3n6m 339 30 transcription transcription NN cord-347946-i6kx3n6m 340 1 ( ( -LRB- cord-347946-i6kx3n6m 340 2 Owczarczyk Owczarczyk NNP cord-347946-i6kx3n6m 340 3 et et NNP cord-347946-i6kx3n6m 340 4 al al NNP cord-347946-i6kx3n6m 340 5 , , , cord-347946-i6kx3n6m 340 6 2015 2015 CD cord-347946-i6kx3n6m 340 7 ; ; : cord-347946-i6kx3n6m 340 8 Tang Tang NNP cord-347946-i6kx3n6m 340 9 et et NNP cord-347946-i6kx3n6m 340 10 al al NNP cord-347946-i6kx3n6m 340 11 , , , cord-347946-i6kx3n6m 340 12 2015 2015 CD cord-347946-i6kx3n6m 340 13 ) ) -RRB- cord-347946-i6kx3n6m 340 14 . . . cord-347946-i6kx3n6m 341 1 Although although IN cord-347946-i6kx3n6m 341 2 a a DT cord-347946-i6kx3n6m 341 3 perusal perusal NN cord-347946-i6kx3n6m 341 4 of of IN cord-347946-i6kx3n6m 341 5 Supplementary Supplementary NNP cord-347946-i6kx3n6m 341 6 Table Table NNP cord-347946-i6kx3n6m 341 7 S3 S3 NNP cord-347946-i6kx3n6m 341 8 highlights highlight VBZ cord-347946-i6kx3n6m 341 9 the the DT cord-347946-i6kx3n6m 341 10 remarkable remarkable JJ cord-347946-i6kx3n6m 341 11 degree degree NN cord-347946-i6kx3n6m 341 12 to to TO cord-347946-i6kx3n6m 341 13 which which WDT cord-347946-i6kx3n6m 341 14 SIRT1 SIRT1 NNS cord-347946-i6kx3n6m 341 15 and and CC cord-347946-i6kx3n6m 341 16 many many JJ cord-347946-i6kx3n6m 341 17 other other JJ cord-347946-i6kx3n6m 341 18 potential potential JJ cord-347946-i6kx3n6m 341 19 depression depression NN cord-347946-i6kx3n6m 341 20 risk risk NN cord-347946-i6kx3n6m 341 21 alleles allele NNS cord-347946-i6kx3n6m 341 22 impact impact VBP cord-347946-i6kx3n6m 341 23 both both DT cord-347946-i6kx3n6m 341 24 immune immune JJ cord-347946-i6kx3n6m 341 25 function function NN cord-347946-i6kx3n6m 341 26 and and CC cord-347946-i6kx3n6m 341 27 pathogen pathogen NN cord-347946-i6kx3n6m 341 28 defense defense NN cord-347946-i6kx3n6m 341 29 , , , cord-347946-i6kx3n6m 341 30 it -PRON- PRP cord-347946-i6kx3n6m 341 31 should should MD cord-347946-i6kx3n6m 341 32 be be VB cord-347946-i6kx3n6m 341 33 noted note VBN cord-347946-i6kx3n6m 341 34 that that IN cord-347946-i6kx3n6m 341 35 there there EX cord-347946-i6kx3n6m 341 36 is be VBZ cord-347946-i6kx3n6m 341 37 another another DT cord-347946-i6kx3n6m 341 38 pathway pathway NN cord-347946-i6kx3n6m 341 39 whereby whereby WRB cord-347946-i6kx3n6m 341 40 these these DT cord-347946-i6kx3n6m 341 41 risk risk NN cord-347946-i6kx3n6m 341 42 alleles allele NNS cord-347946-i6kx3n6m 341 43 might may MD cord-347946-i6kx3n6m 341 44 enhance enhance VB cord-347946-i6kx3n6m 341 45 pathogen pathogen NN cord-347946-i6kx3n6m 341 46 - - HYPH cord-347946-i6kx3n6m 341 47 host host NN cord-347946-i6kx3n6m 341 48 defense defense NN cord-347946-i6kx3n6m 341 49 without without IN cord-347946-i6kx3n6m 341 50 directly directly RB cord-347946-i6kx3n6m 341 51 modulating modulate VBG cord-347946-i6kx3n6m 341 52 immune immune JJ cord-347946-i6kx3n6m 341 53 function function NN cord-347946-i6kx3n6m 341 54 . . . cord-347946-i6kx3n6m 342 1 If if IN cord-347946-i6kx3n6m 342 2 the the DT cord-347946-i6kx3n6m 342 3 PATHOS pathos NN cord-347946-i6kx3n6m 342 4 - - HYPH cord-347946-i6kx3n6m 342 5 D d JJ cord-347946-i6kx3n6m 342 6 proposal proposal NN cord-347946-i6kx3n6m 342 7 that that WDT cord-347946-i6kx3n6m 342 8 depressive depressive JJ cord-347946-i6kx3n6m 342 9 symptoms symptom NNS cord-347946-i6kx3n6m 342 10 themselves -PRON- PRP cord-347946-i6kx3n6m 342 11 serve serve VBP cord-347946-i6kx3n6m 342 12 pathogen pathogen NN cord-347946-i6kx3n6m 342 13 defense defense NN cord-347946-i6kx3n6m 342 14 functions function NNS cord-347946-i6kx3n6m 342 15 is be VBZ cord-347946-i6kx3n6m 342 16 correct correct JJ cord-347946-i6kx3n6m 342 17 , , , cord-347946-i6kx3n6m 342 18 genes gene NNS cord-347946-i6kx3n6m 342 19 that that WDT cord-347946-i6kx3n6m 342 20 promote promote VBP cord-347946-i6kx3n6m 342 21 these these DT cord-347946-i6kx3n6m 342 22 symptoms symptom NNS cord-347946-i6kx3n6m 342 23 might may MD cord-347946-i6kx3n6m 342 24 have have VB cord-347946-i6kx3n6m 342 25 served serve VBN cord-347946-i6kx3n6m 342 26 adaptive adaptive JJ cord-347946-i6kx3n6m 342 27 purposes purpose NNS cord-347946-i6kx3n6m 342 28 in in IN cord-347946-i6kx3n6m 342 29 fighting fight VBG cord-347946-i6kx3n6m 342 30 infection infection NN cord-347946-i6kx3n6m 342 31 via via IN cord-347946-i6kx3n6m 342 32 this this DT cord-347946-i6kx3n6m 342 33 mechanism mechanism NN cord-347946-i6kx3n6m 342 34 alone alone RB cord-347946-i6kx3n6m 342 35 . . . cord-347946-i6kx3n6m 343 1 For for IN cord-347946-i6kx3n6m 343 2 example example NN cord-347946-i6kx3n6m 343 3 , , , cord-347946-i6kx3n6m 343 4 in in IN cord-347946-i6kx3n6m 343 5 addition addition NN cord-347946-i6kx3n6m 343 6 to to IN cord-347946-i6kx3n6m 343 7 multiple multiple JJ cord-347946-i6kx3n6m 343 8 immune immune JJ cord-347946-i6kx3n6m 343 9 effects effect NNS cord-347946-i6kx3n6m 343 10 , , , cord-347946-i6kx3n6m 343 11 sirtuin sirtuin NN cord-347946-i6kx3n6m 343 12 1 1 CD cord-347946-i6kx3n6m 343 13 signaling signal VBG cord-347946-i6kx3n6m 343 14 in in IN cord-347946-i6kx3n6m 343 15 the the DT cord-347946-i6kx3n6m 343 16 hippocampus hippocampus NN cord-347946-i6kx3n6m 343 17 appears appear VBZ cord-347946-i6kx3n6m 343 18 to to TO cord-347946-i6kx3n6m 343 19 have have VB cord-347946-i6kx3n6m 343 20 antidepressant antidepressant JJ cord-347946-i6kx3n6m 343 21 effects effect NNS cord-347946-i6kx3n6m 343 22 , , , cord-347946-i6kx3n6m 343 23 given give VBN cord-347946-i6kx3n6m 343 24 animal animal NN cord-347946-i6kx3n6m 343 25 data datum NNS cord-347946-i6kx3n6m 343 26 that that WDT cord-347946-i6kx3n6m 343 27 pharmacologic pharmacologic JJ cord-347946-i6kx3n6m 343 28 and and CC cord-347946-i6kx3n6m 343 29 genetic genetic JJ cord-347946-i6kx3n6m 343 30 inhibition inhibition NN cord-347946-i6kx3n6m 343 31 of of IN cord-347946-i6kx3n6m 343 32 hippocampal hippocampal JJ cord-347946-i6kx3n6m 343 33 SIRT1 sirt1 NN cord-347946-i6kx3n6m 343 34 function function NN cord-347946-i6kx3n6m 343 35 increases increase VBZ cord-347946-i6kx3n6m 343 36 depression depression NN cord-347946-i6kx3n6m 343 37 - - HYPH cord-347946-i6kx3n6m 343 38 like like JJ cord-347946-i6kx3n6m 343 39 behaviors behavior NNS cord-347946-i6kx3n6m 343 40 in in IN cord-347946-i6kx3n6m 343 41 response response NN cord-347946-i6kx3n6m 343 42 to to IN cord-347946-i6kx3n6m 343 43 stress stress NN cord-347946-i6kx3n6m 343 44 , , , cord-347946-i6kx3n6m 343 45 whereas whereas IN cord-347946-i6kx3n6m 343 46 SIRT1 sirt1 NN cord-347946-i6kx3n6m 343 47 activation activation NN cord-347946-i6kx3n6m 343 48 blocks block VBZ cord-347946-i6kx3n6m 343 49 both both CC cord-347946-i6kx3n6m 343 50 the the DT cord-347946-i6kx3n6m 343 51 development development NN cord-347946-i6kx3n6m 343 52 of of IN cord-347946-i6kx3n6m 343 53 depression depression NN cord-347946-i6kx3n6m 343 54 - - HYPH cord-347946-i6kx3n6m 343 55 related relate VBN cord-347946-i6kx3n6m 343 56 phenotypes phenotype NNS cord-347946-i6kx3n6m 343 57 and and CC cord-347946-i6kx3n6m 343 58 aberrant aberrant JJ cord-347946-i6kx3n6m 343 59 dendritic dendritic JJ cord-347946-i6kx3n6m 343 60 structures structure NNS cord-347946-i6kx3n6m 343 61 elicited elicit VBN cord-347946-i6kx3n6m 343 62 by by IN cord-347946-i6kx3n6m 343 63 chronic chronic JJ cord-347946-i6kx3n6m 343 64 stress stress NN cord-347946-i6kx3n6m 343 65 exposure exposure NN cord-347946-i6kx3n6m 343 66 ( ( -LRB- cord-347946-i6kx3n6m 343 67 Abe Abe NNP cord-347946-i6kx3n6m 343 68 - - HYPH cord-347946-i6kx3n6m 343 69 Higuchi Higuchi NNP cord-347946-i6kx3n6m 343 70 et et NNP cord-347946-i6kx3n6m 343 71 al al NNP cord-347946-i6kx3n6m 343 72 , , , cord-347946-i6kx3n6m 343 73 2016 2016 CD cord-347946-i6kx3n6m 343 74 ) ) -RRB- cord-347946-i6kx3n6m 343 75 . . . cord-347946-i6kx3n6m 344 1 CACNA1C CACNA1C NNP cord-347946-i6kx3n6m 344 2 is be VBZ cord-347946-i6kx3n6m 344 3 another another DT cord-347946-i6kx3n6m 344 4 putative putative JJ cord-347946-i6kx3n6m 344 5 depression depression NN cord-347946-i6kx3n6m 344 6 risk risk NN cord-347946-i6kx3n6m 344 7 gene gene NN cord-347946-i6kx3n6m 344 8 known know VBN cord-347946-i6kx3n6m 344 9 to to IN cord-347946-i6kx3n6m 344 10 both both DT cord-347946-i6kx3n6m 344 11 enhance enhance VB cord-347946-i6kx3n6m 344 12 and and CC cord-347946-i6kx3n6m 344 13 impair impair VB cord-347946-i6kx3n6m 344 14 pathogen pathogen NN cord-347946-i6kx3n6m 344 15 - - HYPH cord-347946-i6kx3n6m 344 16 host host NN cord-347946-i6kx3n6m 344 17 defense defense NN cord-347946-i6kx3n6m 344 18 depending depend VBG cord-347946-i6kx3n6m 344 19 on on IN cord-347946-i6kx3n6m 344 20 the the DT cord-347946-i6kx3n6m 344 21 microorganisms microorganism NNS cord-347946-i6kx3n6m 344 22 involved involve VBN cord-347946-i6kx3n6m 344 23 ( ( -LRB- cord-347946-i6kx3n6m 344 24 Raison Raison NNP cord-347946-i6kx3n6m 344 25 and and CC cord-347946-i6kx3n6m 344 26 Miller Miller NNP cord-347946-i6kx3n6m 344 27 , , , cord-347946-i6kx3n6m 344 28 2012 2012 CD cord-347946-i6kx3n6m 344 29 ) ) -RRB- cord-347946-i6kx3n6m 344 30 . . . cord-347946-i6kx3n6m 345 1 Carriers carrier NNS cord-347946-i6kx3n6m 345 2 of of IN cord-347946-i6kx3n6m 345 3 the the DT cord-347946-i6kx3n6m 345 4 rs1006737 rs1006737 NNS cord-347946-i6kx3n6m 346 1 A a DT cord-347946-i6kx3n6m 346 2 risk risk NN cord-347946-i6kx3n6m 346 3 allele allele NN cord-347946-i6kx3n6m 346 4 have have VBP cord-347946-i6kx3n6m 346 5 also also RB cord-347946-i6kx3n6m 346 6 been be VBN cord-347946-i6kx3n6m 346 7 shown show VBN cord-347946-i6kx3n6m 346 8 in in IN cord-347946-i6kx3n6m 346 9 several several JJ cord-347946-i6kx3n6m 346 10 studies study NNS cord-347946-i6kx3n6m 346 11 to to TO cord-347946-i6kx3n6m 346 12 demonstrate demonstrate VB cord-347946-i6kx3n6m 346 13 changes change NNS cord-347946-i6kx3n6m 346 14 in in IN cord-347946-i6kx3n6m 346 15 brain brain NN cord-347946-i6kx3n6m 346 16 function function NN cord-347946-i6kx3n6m 346 17 and and CC cord-347946-i6kx3n6m 346 18 morphology morphology NN cord-347946-i6kx3n6m 346 19 relevant relevant JJ cord-347946-i6kx3n6m 346 20 to to IN cord-347946-i6kx3n6m 346 21 MDD MDD NNP cord-347946-i6kx3n6m 346 22 ( ( -LRB- cord-347946-i6kx3n6m 346 23 Bigos Bigos NNP cord-347946-i6kx3n6m 346 24 et et FW cord-347946-i6kx3n6m 346 25 al al NNP cord-347946-i6kx3n6m 346 26 , , , cord-347946-i6kx3n6m 346 27 2010 2010 CD cord-347946-i6kx3n6m 346 28 ; ; : cord-347946-i6kx3n6m 346 29 Erk Erk NNP cord-347946-i6kx3n6m 346 30 et et NNP cord-347946-i6kx3n6m 346 31 al al NNP cord-347946-i6kx3n6m 346 32 , , , cord-347946-i6kx3n6m 346 33 2010 2010 CD cord-347946-i6kx3n6m 346 34 ; ; : cord-347946-i6kx3n6m 346 35 Perrier Perrier NNP cord-347946-i6kx3n6m 346 36 et et FW cord-347946-i6kx3n6m 346 37 al al NNP cord-347946-i6kx3n6m 346 38 , , , cord-347946-i6kx3n6m 346 39 2011 2011 CD cord-347946-i6kx3n6m 346 40 ) ) -RRB- cord-347946-i6kx3n6m 346 41 , , , cord-347946-i6kx3n6m 346 42 again again RB cord-347946-i6kx3n6m 346 43 raising raise VBG cord-347946-i6kx3n6m 346 44 the the DT cord-347946-i6kx3n6m 346 45 possibility possibility NN cord-347946-i6kx3n6m 346 46 that that IN cord-347946-i6kx3n6m 346 47 even even RB cord-347946-i6kx3n6m 346 48 genes gene NNS cord-347946-i6kx3n6m 346 49 with with IN cord-347946-i6kx3n6m 346 50 known know VBN cord-347946-i6kx3n6m 346 51 immune immune JJ cord-347946-i6kx3n6m 346 52 effects effect NNS cord-347946-i6kx3n6m 346 53 might may MD cord-347946-i6kx3n6m 346 54 enhance enhance VB cord-347946-i6kx3n6m 346 55 pathogen pathogen NN cord-347946-i6kx3n6m 346 56 defense defense NN cord-347946-i6kx3n6m 346 57 either either CC cord-347946-i6kx3n6m 346 58 primarily primarily RB cord-347946-i6kx3n6m 346 59 , , , cord-347946-i6kx3n6m 346 60 or or CC cord-347946-i6kx3n6m 346 61 synergistically synergistically RB cord-347946-i6kx3n6m 346 62 , , , cord-347946-i6kx3n6m 346 63 via via IN cord-347946-i6kx3n6m 346 64 the the DT cord-347946-i6kx3n6m 346 65 direct direct JJ cord-347946-i6kx3n6m 346 66 induction induction NN cord-347946-i6kx3n6m 346 67 of of IN cord-347946-i6kx3n6m 346 68 depression depression NN cord-347946-i6kx3n6m 346 69 in in IN cord-347946-i6kx3n6m 346 70 response response NN cord-347946-i6kx3n6m 346 71 to to IN cord-347946-i6kx3n6m 346 72 environmental environmental JJ cord-347946-i6kx3n6m 346 73 adversities adversity NNS cord-347946-i6kx3n6m 346 74 known know VBN cord-347946-i6kx3n6m 346 75 to to TO cord-347946-i6kx3n6m 346 76 increase increase VB cord-347946-i6kx3n6m 346 77 the the DT cord-347946-i6kx3n6m 346 78 risk risk NN cord-347946-i6kx3n6m 346 79 for for IN cord-347946-i6kx3n6m 346 80 pathogen pathogen NN cord-347946-i6kx3n6m 346 81 - - HYPH cord-347946-i6kx3n6m 346 82 induced induce VBN cord-347946-i6kx3n6m 346 83 morbidity/ morbidity/ CD cord-347946-i6kx3n6m 346 84 mortality mortality NN cord-347946-i6kx3n6m 346 85 ( ( -LRB- cord-347946-i6kx3n6m 346 86 ie ie FW cord-347946-i6kx3n6m 346 87 , , , cord-347946-i6kx3n6m 346 88 stress stress NN cord-347946-i6kx3n6m 346 89 signaling signal VBG cord-347946-i6kx3n6m 346 90 an an DT cord-347946-i6kx3n6m 346 91 increased increase VBN cord-347946-i6kx3n6m 346 92 risk risk NN cord-347946-i6kx3n6m 346 93 of of IN cord-347946-i6kx3n6m 346 94 wounding wounding NN cord-347946-i6kx3n6m 346 95 , , , cord-347946-i6kx3n6m 346 96 active active JJ cord-347946-i6kx3n6m 346 97 infection infection NN cord-347946-i6kx3n6m 346 98 ; ; : cord-347946-i6kx3n6m 346 99 Bigos bigos FW cord-347946-i6kx3n6m 346 100 et et FW cord-347946-i6kx3n6m 346 101 al al NNP cord-347946-i6kx3n6m 346 102 , , , cord-347946-i6kx3n6m 346 103 2010 2010 CD cord-347946-i6kx3n6m 346 104 ; ; : cord-347946-i6kx3n6m 346 105 Erk Erk NNP cord-347946-i6kx3n6m 346 106 et et NNP cord-347946-i6kx3n6m 346 107 al al NNP cord-347946-i6kx3n6m 346 108 , , , cord-347946-i6kx3n6m 346 109 2010 2010 CD cord-347946-i6kx3n6m 346 110 ; ; : cord-347946-i6kx3n6m 346 111 Perrier Perrier NNP cord-347946-i6kx3n6m 346 112 et et FW cord-347946-i6kx3n6m 346 113 al al NNP cord-347946-i6kx3n6m 346 114 , , , cord-347946-i6kx3n6m 346 115 2011 2011 CD cord-347946-i6kx3n6m 346 116 ) ) -RRB- cord-347946-i6kx3n6m 346 117 . . . cord-347946-i6kx3n6m 347 1 Understanding understand VBG cord-347946-i6kx3n6m 347 2 the the DT cord-347946-i6kx3n6m 347 3 impact impact NN cord-347946-i6kx3n6m 347 4 of of IN cord-347946-i6kx3n6m 347 5 putative putative JJ cord-347946-i6kx3n6m 347 6 risk risk NN cord-347946-i6kx3n6m 347 7 genes gene NNS cord-347946-i6kx3n6m 347 8 like like IN cord-347946-i6kx3n6m 347 9 SIRT1 SIRT1 NNP cord-347946-i6kx3n6m 347 10 or or CC cord-347946-i6kx3n6m 347 11 CACNA1C CACNA1C NNP cord-347946-i6kx3n6m 347 12 on on IN cord-347946-i6kx3n6m 347 13 inflammatory inflammatory JJ cord-347946-i6kx3n6m 347 14 and and CC cord-347946-i6kx3n6m 347 15 behavioral behavioral JJ cord-347946-i6kx3n6m 347 16 responses response NNS cord-347946-i6kx3n6m 347 17 to to IN cord-347946-i6kx3n6m 347 18 psychosocial psychosocial JJ cord-347946-i6kx3n6m 347 19 stress stress NN cord-347946-i6kx3n6m 347 20 would would MD cord-347946-i6kx3n6m 347 21 provide provide VB cord-347946-i6kx3n6m 347 22 invaluable invaluable JJ cord-347946-i6kx3n6m 347 23 insight insight NN cord-347946-i6kx3n6m 347 24 into into IN cord-347946-i6kx3n6m 347 25 the the DT cord-347946-i6kx3n6m 347 26 question question NN cord-347946-i6kx3n6m 347 27 of of IN cord-347946-i6kx3n6m 347 28 whether whether IN cord-347946-i6kx3n6m 347 29 they -PRON- PRP cord-347946-i6kx3n6m 347 30 promote promote VBP cord-347946-i6kx3n6m 347 31 depression depression NN cord-347946-i6kx3n6m 347 32 and and CC cord-347946-i6kx3n6m 347 33 pathogen pathogen NN cord-347946-i6kx3n6m 347 34 - - HYPH cord-347946-i6kx3n6m 347 35 host host NN cord-347946-i6kx3n6m 347 36 defense defense NN cord-347946-i6kx3n6m 347 37 via via IN cord-347946-i6kx3n6m 347 38 the the DT cord-347946-i6kx3n6m 347 39 type type NN cord-347946-i6kx3n6m 347 40 of of IN cord-347946-i6kx3n6m 347 41 inflammatory inflammatory JJ cord-347946-i6kx3n6m 347 42 activation activation NN cord-347946-i6kx3n6m 347 43 that that WDT cord-347946-i6kx3n6m 347 44 is be VBZ cord-347946-i6kx3n6m 347 45 a a DT cord-347946-i6kx3n6m 347 46 hallmark hallmark NN cord-347946-i6kx3n6m 347 47 of of IN cord-347946-i6kx3n6m 347 48 MDD MDD NNP cord-347946-i6kx3n6m 347 49 in in IN cord-347946-i6kx3n6m 347 50 the the DT cord-347946-i6kx3n6m 347 51 modern modern JJ cord-347946-i6kx3n6m 347 52 world world NN cord-347946-i6kx3n6m 347 53 . . . cord-347946-i6kx3n6m 348 1 PATHOS pathos NN cord-347946-i6kx3n6m 348 2 - - HYPH cord-347946-i6kx3n6m 348 3 D D NNP cord-347946-i6kx3n6m 348 4 proposes propose VBZ cord-347946-i6kx3n6m 348 5 that that IN cord-347946-i6kx3n6m 348 6 depression depression NN cord-347946-i6kx3n6m 348 7 risk risk NN cord-347946-i6kx3n6m 348 8 alleles allele NNS cord-347946-i6kx3n6m 348 9 have have VBP cord-347946-i6kx3n6m 348 10 been be VBN cord-347946-i6kx3n6m 348 11 maintained maintain VBN cord-347946-i6kx3n6m 348 12 in in IN cord-347946-i6kx3n6m 348 13 the the DT cord-347946-i6kx3n6m 348 14 human human JJ cord-347946-i6kx3n6m 348 15 genome genome NN cord-347946-i6kx3n6m 348 16 primarily primarily RB cord-347946-i6kx3n6m 348 17 because because IN cord-347946-i6kx3n6m 348 18 , , , cord-347946-i6kx3n6m 348 19 by by IN cord-347946-i6kx3n6m 348 20 enhancing enhance VBG cord-347946-i6kx3n6m 348 21 pathogen pathogen NN cord-347946-i6kx3n6m 348 22 - - HYPH cord-347946-i6kx3n6m 348 23 host host NN cord-347946-i6kx3n6m 348 24 defense defense NN cord-347946-i6kx3n6m 348 25 , , , cord-347946-i6kx3n6m 348 26 they -PRON- PRP cord-347946-i6kx3n6m 348 27 provided provide VBD cord-347946-i6kx3n6m 348 28 a a DT cord-347946-i6kx3n6m 348 29 net net JJ cord-347946-i6kx3n6m 348 30 survival survival NN cord-347946-i6kx3n6m 348 31 and and CC cord-347946-i6kx3n6m 348 32 reproductive reproductive JJ cord-347946-i6kx3n6m 348 33 advantage advantage NN cord-347946-i6kx3n6m 348 34 . . . cord-347946-i6kx3n6m 349 1 A a DT cord-347946-i6kx3n6m 349 2 primary primary JJ cord-347946-i6kx3n6m 349 3 problem problem NN cord-347946-i6kx3n6m 349 4 that that IN cord-347946-i6kx3n6m 349 5 this this DT cord-347946-i6kx3n6m 349 6 theory theory NN cord-347946-i6kx3n6m 349 7 shares share VBZ cord-347946-i6kx3n6m 349 8 with with IN cord-347946-i6kx3n6m 349 9 other other JJ cord-347946-i6kx3n6m 349 10 adaptive adaptive JJ cord-347946-i6kx3n6m 349 11 explanations explanation NNS cord-347946-i6kx3n6m 349 12 for for IN cord-347946-i6kx3n6m 349 13 depression depression NN cord-347946-i6kx3n6m 349 14 is be VBZ cord-347946-i6kx3n6m 349 15 that that DT cord-347946-i6kx3n6m 349 16 to to IN cord-347946-i6kx3n6m 349 17 date date VB cord-347946-i6kx3n6m 349 18 no no DT cord-347946-i6kx3n6m 349 19 incontrovertible incontrovertible JJ cord-347946-i6kx3n6m 349 20 risk risk NN cord-347946-i6kx3n6m 349 21 alleles allele NNS cord-347946-i6kx3n6m 349 22 for for IN cord-347946-i6kx3n6m 349 23 MDD MDD NNP cord-347946-i6kx3n6m 349 24 have have VBP cord-347946-i6kx3n6m 349 25 been be VBN cord-347946-i6kx3n6m 349 26 identified identify VBN cord-347946-i6kx3n6m 349 27 . . . cord-347946-i6kx3n6m 350 1 Indeed indeed RB cord-347946-i6kx3n6m 350 2 , , , cord-347946-i6kx3n6m 350 3 most most RBS cord-347946-i6kx3n6m 350 4 large large JJ cord-347946-i6kx3n6m 350 5 GWAS GWAS NNP cord-347946-i6kx3n6m 350 6 have have VBP cord-347946-i6kx3n6m 350 7 failed fail VBN cord-347946-i6kx3n6m 350 8 to to TO cord-347946-i6kx3n6m 350 9 find find VB cord-347946-i6kx3n6m 350 10 SNPs snp NNS cord-347946-i6kx3n6m 350 11 that that WDT cord-347946-i6kx3n6m 350 12 meet meet VBP cord-347946-i6kx3n6m 350 13 genome genome NN cord-347946-i6kx3n6m 350 14 - - HYPH cord-347946-i6kx3n6m 350 15 wide wide JJ cord-347946-i6kx3n6m 350 16 significance significance NN cord-347946-i6kx3n6m 350 17 and and CC cord-347946-i6kx3n6m 350 18 when when WRB cord-347946-i6kx3n6m 350 19 such such JJ cord-347946-i6kx3n6m 350 20 SNPs snp NNS cord-347946-i6kx3n6m 350 21 are be VBP cord-347946-i6kx3n6m 350 22 found find VBN cord-347946-i6kx3n6m 350 23 ( ( -LRB- cord-347946-i6kx3n6m 350 24 ie ie FW cord-347946-i6kx3n6m 350 25 , , , cord-347946-i6kx3n6m 350 26 rs12520799 rs12520799 VBN cord-347946-i6kx3n6m 350 27 in in IN cord-347946-i6kx3n6m 350 28 DCNP1 DCNP1 NNS cord-347946-i6kx3n6m 350 29 and and CC cord-347946-i6kx3n6m 350 30 rs76917 rs76917 NNP cord-347946-i6kx3n6m 350 31 in in IN cord-347946-i6kx3n6m 350 32 TNF TNF NNP cord-347946-i6kx3n6m 350 33 ) ) -RRB- cord-347946-i6kx3n6m 351 1 they -PRON- PRP cord-347946-i6kx3n6m 351 2 are be VBP cord-347946-i6kx3n6m 351 3 not not RB cord-347946-i6kx3n6m 351 4 replicated replicate VBN cord-347946-i6kx3n6m 351 5 in in IN cord-347946-i6kx3n6m 351 6 GWAS GWAS NNP cord-347946-i6kx3n6m 351 7 conducted conduct VBN cord-347946-i6kx3n6m 351 8 in in IN cord-347946-i6kx3n6m 351 9 other other JJ cord-347946-i6kx3n6m 351 10 populations population NNS cord-347946-i6kx3n6m 351 11 ( ( -LRB- cord-347946-i6kx3n6m 351 12 Raison Raison NNP cord-347946-i6kx3n6m 351 13 and and CC cord-347946-i6kx3n6m 351 14 Miller Miller NNP cord-347946-i6kx3n6m 351 15 , , , cord-347946-i6kx3n6m 351 16 2012 2012 CD cord-347946-i6kx3n6m 351 17 ) ) -RRB- cord-347946-i6kx3n6m 351 18 . . . cord-347946-i6kx3n6m 352 1 Multiple multiple JJ cord-347946-i6kx3n6m 352 2 explanations explanation NNS cord-347946-i6kx3n6m 352 3 have have VBP cord-347946-i6kx3n6m 352 4 been be VBN cord-347946-i6kx3n6m 352 5 offered offer VBN cord-347946-i6kx3n6m 352 6 for for IN cord-347946-i6kx3n6m 352 7 this this DT cord-347946-i6kx3n6m 352 8 case case NN cord-347946-i6kx3n6m 352 9 of of IN cord-347946-i6kx3n6m 352 10 ' ' `` cord-347946-i6kx3n6m 352 11 missing miss VBG cord-347946-i6kx3n6m 352 12 depression depression NN cord-347946-i6kx3n6m 352 13 genes gene NNS cord-347946-i6kx3n6m 352 14 , , , cord-347946-i6kx3n6m 352 15 ' ' '' cord-347946-i6kx3n6m 352 16 most most RBS cord-347946-i6kx3n6m 352 17 often often RB cord-347946-i6kx3n6m 352 18 that that IN cord-347946-i6kx3n6m 352 19 MDD MDD NNP cord-347946-i6kx3n6m 352 20 is be VBZ cord-347946-i6kx3n6m 352 21 heterogeneous heterogeneous JJ cord-347946-i6kx3n6m 352 22 in in IN cord-347946-i6kx3n6m 352 23 relation relation NN cord-347946-i6kx3n6m 352 24 to to IN cord-347946-i6kx3n6m 352 25 its -PRON- PRP$ cord-347946-i6kx3n6m 352 26 environmental environmental JJ cord-347946-i6kx3n6m 352 27 antecedents antecedent NNS cord-347946-i6kx3n6m 352 28 , , , cord-347946-i6kx3n6m 352 29 the the DT cord-347946-i6kx3n6m 352 30 nature nature NN cord-347946-i6kx3n6m 352 31 and and CC cord-347946-i6kx3n6m 352 32 severity severity NN cord-347946-i6kx3n6m 352 33 of of IN cord-347946-i6kx3n6m 352 34 its -PRON- PRP$ cord-347946-i6kx3n6m 352 35 symptoms symptom NNS cord-347946-i6kx3n6m 352 36 and and CC cord-347946-i6kx3n6m 352 37 its -PRON- PRP$ cord-347946-i6kx3n6m 352 38 disease disease NN cord-347946-i6kx3n6m 352 39 course course NN cord-347946-i6kx3n6m 352 40 ; ; : cord-347946-i6kx3n6m 352 41 and and CC cord-347946-i6kx3n6m 352 42 that that IN cord-347946-i6kx3n6m 352 43 therefore therefore RB cord-347946-i6kx3n6m 352 44 it -PRON- PRP cord-347946-i6kx3n6m 352 45 is be VBZ cord-347946-i6kx3n6m 352 46 likely likely JJ cord-347946-i6kx3n6m 352 47 that that IN cord-347946-i6kx3n6m 352 48 the the DT cord-347946-i6kx3n6m 352 49 condition condition NN cord-347946-i6kx3n6m 352 50 is be VBZ cord-347946-i6kx3n6m 352 51 a a DT cord-347946-i6kx3n6m 352 52 concatenation concatenation NN cord-347946-i6kx3n6m 352 53 of of IN cord-347946-i6kx3n6m 352 54 numerous numerous JJ cord-347946-i6kx3n6m 352 55 as as IN cord-347946-i6kx3n6m 352 56 - - HYPH cord-347946-i6kx3n6m 352 57 yet yet RB cord-347946-i6kx3n6m 352 58 - - HYPH cord-347946-i6kx3n6m 352 59 unidentified unidentified JJ cord-347946-i6kx3n6m 352 60 more more JJR cord-347946-i6kx3n6m 352 61 etiologically etiologically RB cord-347946-i6kx3n6m 352 62 homogeneous homogeneous JJ cord-347946-i6kx3n6m 352 63 sub sub NN cord-347946-i6kx3n6m 352 64 - - NNS cord-347946-i6kx3n6m 352 65 conditions condition NNS cord-347946-i6kx3n6m 352 66 that that WDT cord-347946-i6kx3n6m 352 67 are be VBP cord-347946-i6kx3n6m 352 68 likely likely JJ cord-347946-i6kx3n6m 352 69 to to TO cord-347946-i6kx3n6m 352 70 be be VB cord-347946-i6kx3n6m 352 71 more more RBR cord-347946-i6kx3n6m 352 72 genetically genetically RB cord-347946-i6kx3n6m 352 73 consistent consistent JJ cord-347946-i6kx3n6m 352 74 . . . cord-347946-i6kx3n6m 353 1 Although although IN cord-347946-i6kx3n6m 353 2 not not RB cord-347946-i6kx3n6m 353 3 dismissing dismiss VBG cord-347946-i6kx3n6m 353 4 disease disease NN cord-347946-i6kx3n6m 353 5 heterogeneity heterogeneity NN cord-347946-i6kx3n6m 353 6 as as IN cord-347946-i6kx3n6m 353 7 a a DT cord-347946-i6kx3n6m 353 8 cause cause NN cord-347946-i6kx3n6m 353 9 for for IN cord-347946-i6kx3n6m 353 10 failure failure NN cord-347946-i6kx3n6m 353 11 to to TO cord-347946-i6kx3n6m 353 12 replicate replicate VB cord-347946-i6kx3n6m 353 13 depressive depressive JJ cord-347946-i6kx3n6m 353 14 risk risk NN cord-347946-i6kx3n6m 353 15 alleles allele NNS cord-347946-i6kx3n6m 353 16 , , , cord-347946-i6kx3n6m 353 17 PATHOS pathos NN cord-347946-i6kx3n6m 353 18 - - HYPH cord-347946-i6kx3n6m 353 19 D D NNP cord-347946-i6kx3n6m 353 20 offers offer VBZ cord-347946-i6kx3n6m 353 21 an an DT cord-347946-i6kx3n6m 353 22 additional additional JJ cord-347946-i6kx3n6m 353 23 novel novel JJ cord-347946-i6kx3n6m 353 24 explanation explanation NN cord-347946-i6kx3n6m 353 25 for for IN cord-347946-i6kx3n6m 353 26 at at IN cord-347946-i6kx3n6m 353 27 least least JJS cord-347946-i6kx3n6m 353 28 some some DT cord-347946-i6kx3n6m 353 29 cases case NNS cord-347946-i6kx3n6m 353 30 of of IN cord-347946-i6kx3n6m 353 31 replication replication NN cord-347946-i6kx3n6m 353 32 failure failure NN cord-347946-i6kx3n6m 353 33 . . . cord-347946-i6kx3n6m 354 1 Because because IN cord-347946-i6kx3n6m 354 2 pathogens pathogen NNS cord-347946-i6kx3n6m 354 3 can can MD cord-347946-i6kx3n6m 354 4 develop develop VB cord-347946-i6kx3n6m 354 5 resistance resistance NN cord-347946-i6kx3n6m 354 6 to to TO cord-347946-i6kx3n6m 354 7 host host VB cord-347946-i6kx3n6m 354 8 immune immune JJ cord-347946-i6kx3n6m 354 9 defenses defense NNS cord-347946-i6kx3n6m 354 10 , , , cord-347946-i6kx3n6m 354 11 or or CC cord-347946-i6kx3n6m 354 12 in in IN cord-347946-i6kx3n6m 354 13 many many JJ cord-347946-i6kx3n6m 354 14 cases case NNS cord-347946-i6kx3n6m 354 15 actually actually RB cord-347946-i6kx3n6m 354 16 evolve evolve VBP cord-347946-i6kx3n6m 354 17 to to TO cord-347946-i6kx3n6m 354 18 benefit benefit VB cord-347946-i6kx3n6m 354 19 from from IN cord-347946-i6kx3n6m 354 20 these these DT cord-347946-i6kx3n6m 354 21 defenses defense NNS cord-347946-i6kx3n6m 354 22 via via IN cord-347946-i6kx3n6m 354 23 pathogen pathogen NN cord-347946-i6kx3n6m 354 24 manipulation manipulation NN cord-347946-i6kx3n6m 354 25 strategies strategy NNS cord-347946-i6kx3n6m 354 26 , , , cord-347946-i6kx3n6m 354 27 not not RB cord-347946-i6kx3n6m 354 28 all all DT cord-347946-i6kx3n6m 354 29 genetically genetically RB cord-347946-i6kx3n6m 354 30 programmed program VBN cord-347946-i6kx3n6m 354 31 physiological physiological JJ cord-347946-i6kx3n6m 354 32 or or CC cord-347946-i6kx3n6m 354 33 behavioral behavioral JJ cord-347946-i6kx3n6m 354 34 pathogen pathogen NN cord-347946-i6kx3n6m 354 35 - - HYPH cord-347946-i6kx3n6m 354 36 host host NN cord-347946-i6kx3n6m 354 37 defense defense NN cord-347946-i6kx3n6m 354 38 strategies strategy NNS cord-347946-i6kx3n6m 354 39 will will MD cord-347946-i6kx3n6m 354 40 be be VB cord-347946-i6kx3n6m 354 41 equally equally RB cord-347946-i6kx3n6m 354 42 effective effective JJ cord-347946-i6kx3n6m 354 43 against against IN cord-347946-i6kx3n6m 354 44 all all DT cord-347946-i6kx3n6m 354 45 microbes microbe NNS cord-347946-i6kx3n6m 354 46 . . . cord-347946-i6kx3n6m 355 1 Because because IN cord-347946-i6kx3n6m 355 2 of of IN cord-347946-i6kx3n6m 355 3 this this DT cord-347946-i6kx3n6m 355 4 , , , cord-347946-i6kx3n6m 355 5 in in IN cord-347946-i6kx3n6m 355 6 cultures culture NNS cord-347946-i6kx3n6m 355 7 / / SYM cord-347946-i6kx3n6m 355 8 societies society NNS cord-347946-i6kx3n6m 355 9 exposed expose VBN cord-347946-i6kx3n6m 355 10 to to IN cord-347946-i6kx3n6m 355 11 different different JJ cord-347946-i6kx3n6m 355 12 mixtures mixture NNS cord-347946-i6kx3n6m 355 13 of of IN cord-347946-i6kx3n6m 355 14 pathogens pathogen NNS cord-347946-i6kx3n6m 355 15 across across IN cord-347946-i6kx3n6m 355 16 time time NN cord-347946-i6kx3n6m 355 17 , , , cord-347946-i6kx3n6m 355 18 different different JJ cord-347946-i6kx3n6m 355 19 immune immune JJ cord-347946-i6kx3n6m 355 20 mechanisms mechanism NNS cord-347946-i6kx3n6m 355 21 will will MD cord-347946-i6kx3n6m 355 22 be be VB cord-347946-i6kx3n6m 355 23 adaptive adaptive JJ cord-347946-i6kx3n6m 355 24 , , , cord-347946-i6kx3n6m 355 25 and and CC cord-347946-i6kx3n6m 355 26 therefore therefore RB cord-347946-i6kx3n6m 355 27 likely likely JJ cord-347946-i6kx3n6m 355 28 to to TO cord-347946-i6kx3n6m 355 29 become become VB cord-347946-i6kx3n6m 355 30 linked link VBN cord-347946-i6kx3n6m 355 31 to to IN cord-347946-i6kx3n6m 355 32 depression depression NN cord-347946-i6kx3n6m 355 33 . . . cord-347946-i6kx3n6m 356 1 Said say VBD cord-347946-i6kx3n6m 356 2 differently differently RB cord-347946-i6kx3n6m 356 3 , , , cord-347946-i6kx3n6m 356 4 because because IN cord-347946-i6kx3n6m 356 5 of of IN cord-347946-i6kx3n6m 356 6 geographic geographic JJ cord-347946-i6kx3n6m 356 7 and and CC cord-347946-i6kx3n6m 356 8 historical historical JJ cord-347946-i6kx3n6m 356 9 differences difference NNS cord-347946-i6kx3n6m 356 10 in in IN cord-347946-i6kx3n6m 356 11 pathogen pathogen NN cord-347946-i6kx3n6m 356 12 exposure exposure NN cord-347946-i6kx3n6m 356 13 , , , cord-347946-i6kx3n6m 356 14 we -PRON- PRP cord-347946-i6kx3n6m 356 15 should should MD cord-347946-i6kx3n6m 356 16 not not RB cord-347946-i6kx3n6m 356 17 expect expect VB cord-347946-i6kx3n6m 356 18 all all DT cord-347946-i6kx3n6m 356 19 human human JJ cord-347946-i6kx3n6m 356 20 ethnic ethnic JJ cord-347946-i6kx3n6m 356 21 / / SYM cord-347946-i6kx3n6m 356 22 racial racial JJ cord-347946-i6kx3n6m 356 23 groups group NNS cord-347946-i6kx3n6m 356 24 to to TO cord-347946-i6kx3n6m 356 25 have have VB cord-347946-i6kx3n6m 356 26 benefitted benefit VBN cord-347946-i6kx3n6m 356 27 from from IN cord-347946-i6kx3n6m 356 28 the the DT cord-347946-i6kx3n6m 356 29 same same JJ cord-347946-i6kx3n6m 356 30 genetically genetically RB cord-347946-i6kx3n6m 356 31 driven drive VBN cord-347946-i6kx3n6m 356 32 pathogen pathogen NN cord-347946-i6kx3n6m 356 33 defense defense NN cord-347946-i6kx3n6m 356 34 strategies strategy NNS cord-347946-i6kx3n6m 356 35 and and CC cord-347946-i6kx3n6m 356 36 therefore therefore RB cord-347946-i6kx3n6m 356 37 to to TO cord-347946-i6kx3n6m 356 38 show show VB cord-347946-i6kx3n6m 356 39 the the DT cord-347946-i6kx3n6m 356 40 same same JJ cord-347946-i6kx3n6m 356 41 risk risk NN cord-347946-i6kx3n6m 356 42 alleles allele NNS cord-347946-i6kx3n6m 356 43 for for IN cord-347946-i6kx3n6m 356 44 MDD MDD NNP cord-347946-i6kx3n6m 356 45 . . . cord-347946-i6kx3n6m 357 1 Thus thus RB cord-347946-i6kx3n6m 357 2 , , , cord-347946-i6kx3n6m 357 3 a a DT cord-347946-i6kx3n6m 357 4 PATHOS pathos NN cord-347946-i6kx3n6m 357 5 - - HYPH cord-347946-i6kx3n6m 357 6 D d JJ cord-347946-i6kx3n6m 357 7 perspective perspective NN cord-347946-i6kx3n6m 357 8 suggests suggest VBZ cord-347946-i6kx3n6m 357 9 that that IN cord-347946-i6kx3n6m 357 10 understanding understand VBG cord-347946-i6kx3n6m 357 11 the the DT cord-347946-i6kx3n6m 357 12 specific specific JJ cord-347946-i6kx3n6m 357 13 histories history NNS cord-347946-i6kx3n6m 357 14 of of IN cord-347946-i6kx3n6m 357 15 shared share VBN cord-347946-i6kx3n6m 357 16 and and CC cord-347946-i6kx3n6m 357 17 unique unique JJ cord-347946-i6kx3n6m 357 18 co co NN cord-347946-i6kx3n6m 357 19 - - JJ cord-347946-i6kx3n6m 357 20 evolved evolved JJ cord-347946-i6kx3n6m 357 21 pathogen pathogen NN cord-347946-i6kx3n6m 357 22 - - HYPH cord-347946-i6kx3n6m 357 23 host host NN cord-347946-i6kx3n6m 357 24 interactions interaction NNS cord-347946-i6kx3n6m 357 25 within within IN cord-347946-i6kx3n6m 357 26 and and CC cord-347946-i6kx3n6m 357 27 across across IN cord-347946-i6kx3n6m 357 28 human human JJ cord-347946-i6kx3n6m 357 29 societies society NNS cord-347946-i6kx3n6m 357 30 will will MD cord-347946-i6kx3n6m 357 31 be be VB cord-347946-i6kx3n6m 357 32 essential essential JJ cord-347946-i6kx3n6m 357 33 for for IN cord-347946-i6kx3n6m 357 34 enhancing enhance VBG cord-347946-i6kx3n6m 357 35 our -PRON- PRP$ cord-347946-i6kx3n6m 357 36 understanding understanding NN cord-347946-i6kx3n6m 357 37 of of IN cord-347946-i6kx3n6m 357 38 why why WRB cord-347946-i6kx3n6m 357 39 genotype genotype NN cord-347946-i6kx3n6m 357 40 - - HYPH cord-347946-i6kx3n6m 357 41 phenotype phenotype NN cord-347946-i6kx3n6m 357 42 associations association NNS cord-347946-i6kx3n6m 357 43 observed observe VBN cord-347946-i6kx3n6m 357 44 in in IN cord-347946-i6kx3n6m 357 45 one one CD cord-347946-i6kx3n6m 357 46 population population NN cord-347946-i6kx3n6m 357 47 do do VBP cord-347946-i6kx3n6m 357 48 or or CC cord-347946-i6kx3n6m 357 49 do do VBP cord-347946-i6kx3n6m 357 50 not not RB cord-347946-i6kx3n6m 357 51 replicate replicate VB cord-347946-i6kx3n6m 357 52 across across IN cord-347946-i6kx3n6m 357 53 other other JJ cord-347946-i6kx3n6m 357 54 populations population NNS cord-347946-i6kx3n6m 357 55 , , , cord-347946-i6kx3n6m 357 56 as as RB cord-347946-i6kx3n6m 357 57 well well RB cord-347946-i6kx3n6m 357 58 as as IN cord-347946-i6kx3n6m 357 59 why why WRB cord-347946-i6kx3n6m 357 60 certain certain JJ cord-347946-i6kx3n6m 357 61 genetic genetic JJ cord-347946-i6kx3n6m 357 62 variants variant NNS cord-347946-i6kx3n6m 357 63 drive drive VBP cord-347946-i6kx3n6m 357 64 physiological physiological JJ cord-347946-i6kx3n6m 357 65 processes process NNS cord-347946-i6kx3n6m 357 66 that that WDT cord-347946-i6kx3n6m 357 67 induce induce VBP cord-347946-i6kx3n6m 357 68 depression depression NN cord-347946-i6kx3n6m 357 69 in in IN cord-347946-i6kx3n6m 357 70 certain certain JJ cord-347946-i6kx3n6m 357 71 individuals individual NNS cord-347946-i6kx3n6m 357 72 but but CC cord-347946-i6kx3n6m 357 73 not not RB cord-347946-i6kx3n6m 357 74 in in IN cord-347946-i6kx3n6m 357 75 others other NNS cord-347946-i6kx3n6m 357 76 . . . cord-347946-i6kx3n6m 358 1 These these DT cord-347946-i6kx3n6m 358 2 insights insight NNS cord-347946-i6kx3n6m 358 3 may may MD cord-347946-i6kx3n6m 358 4 help help VB cord-347946-i6kx3n6m 358 5 account account VB cord-347946-i6kx3n6m 358 6 for for IN cord-347946-i6kx3n6m 358 7 the the DT cord-347946-i6kx3n6m 358 8 intriguing intriguing JJ cord-347946-i6kx3n6m 358 9 finding finding NN cord-347946-i6kx3n6m 358 10 that that IN cord-347946-i6kx3n6m 358 11 the the DT cord-347946-i6kx3n6m 358 12 association association NN cord-347946-i6kx3n6m 358 13 between between IN cord-347946-i6kx3n6m 358 14 SIR1 SIR1 NNP cord-347946-i6kx3n6m 358 15 nor nor CC cord-347946-i6kx3n6m 358 16 LHPP LHPP NNP cord-347946-i6kx3n6m 358 17 SNPs SNPs NNPS cord-347946-i6kx3n6m 358 18 and and CC cord-347946-i6kx3n6m 358 19 MDD MDD NNP cord-347946-i6kx3n6m 358 20 identified identify VBD cord-347946-i6kx3n6m 358 21 in in IN cord-347946-i6kx3n6m 358 22 Han Han NNP cord-347946-i6kx3n6m 358 23 Chinese chinese JJ cord-347946-i6kx3n6m 358 24 females female NNS cord-347946-i6kx3n6m 358 25 was be VBD cord-347946-i6kx3n6m 358 26 not not RB cord-347946-i6kx3n6m 358 27 replicated replicate VBN cord-347946-i6kx3n6m 358 28 in in IN cord-347946-i6kx3n6m 358 29 European european JJ cord-347946-i6kx3n6m 358 30 populations population NNS cord-347946-i6kx3n6m 358 31 ( ( -LRB- cord-347946-i6kx3n6m 358 32 Consortium Consortium NNP cord-347946-i6kx3n6m 358 33 C C NNP cord-347946-i6kx3n6m 358 34 ( ( -LRB- cord-347946-i6kx3n6m 358 35 2015 2015 CD cord-347946-i6kx3n6m 358 36 ) ) -RRB- cord-347946-i6kx3n6m 358 37 ) ) -RRB- cord-347946-i6kx3n6m 358 38 . . . cord-347946-i6kx3n6m 359 1 PATHOS pathos NN cord-347946-i6kx3n6m 359 2 - - HYPH cord-347946-i6kx3n6m 359 3 D D NNP cord-347946-i6kx3n6m 359 4 would would MD cord-347946-i6kx3n6m 359 5 predict predict VB cord-347946-i6kx3n6m 359 6 that that IN cord-347946-i6kx3n6m 359 7 this this DT cord-347946-i6kx3n6m 359 8 finding finding NN cord-347946-i6kx3n6m 359 9 might may MD cord-347946-i6kx3n6m 359 10 be be VB cord-347946-i6kx3n6m 359 11 accounted account VBN cord-347946-i6kx3n6m 359 12 for for IN cord-347946-i6kx3n6m 359 13 by by IN cord-347946-i6kx3n6m 359 14 the the DT cord-347946-i6kx3n6m 359 15 fact fact NN cord-347946-i6kx3n6m 359 16 that that IN cord-347946-i6kx3n6m 359 17 SIRT1 SIRT1 NNP cord-347946-i6kx3n6m 359 18 and and CC cord-347946-i6kx3n6m 359 19 LHPP LHPP NNP cord-347946-i6kx3n6m 359 20 conferred confer VBD cord-347946-i6kx3n6m 359 21 specific specific JJ cord-347946-i6kx3n6m 359 22 anti anti JJ cord-347946-i6kx3n6m 359 23 - - JJ cord-347946-i6kx3n6m 359 24 pathogen pathogen JJ cord-347946-i6kx3n6m 359 25 defenses defense NNS cord-347946-i6kx3n6m 359 26 in in IN cord-347946-i6kx3n6m 359 27 the the DT cord-347946-i6kx3n6m 359 28 Chinese chinese JJ cord-347946-i6kx3n6m 359 29 environment environment NN cord-347946-i6kx3n6m 359 30 that that WDT cord-347946-i6kx3n6m 359 31 were be VBD cord-347946-i6kx3n6m 359 32 not not RB cord-347946-i6kx3n6m 359 33 relevant relevant JJ cord-347946-i6kx3n6m 359 34 in in IN cord-347946-i6kx3n6m 359 35 Europe Europe NNP cord-347946-i6kx3n6m 359 36 . . . cord-347946-i6kx3n6m 360 1 If if IN cord-347946-i6kx3n6m 360 2 so so RB cord-347946-i6kx3n6m 360 3 , , , cord-347946-i6kx3n6m 360 4 one one PRP cord-347946-i6kx3n6m 360 5 would would MD cord-347946-i6kx3n6m 360 6 expect expect VB cord-347946-i6kx3n6m 360 7 the the DT cord-347946-i6kx3n6m 360 8 prevalence prevalence NN cord-347946-i6kx3n6m 360 9 of of IN cord-347946-i6kx3n6m 360 10 the the DT cord-347946-i6kx3n6m 360 11 SIRT1 SIRT1 NNS cord-347946-i6kx3n6m 360 12 and and CC cord-347946-i6kx3n6m 360 13 LHPP LHPP NNP cord-347946-i6kx3n6m 360 14 risk risk NN cord-347946-i6kx3n6m 360 15 alleles allele NNS cord-347946-i6kx3n6m 360 16 to to TO cord-347946-i6kx3n6m 360 17 be be VB cord-347946-i6kx3n6m 360 18 significantly significantly RB cord-347946-i6kx3n6m 360 19 higher high JJR cord-347946-i6kx3n6m 360 20 in in IN cord-347946-i6kx3n6m 360 21 Han Han NNP cord-347946-i6kx3n6m 360 22 populations population NNS cord-347946-i6kx3n6m 360 23 than than IN cord-347946-i6kx3n6m 360 24 in in IN cord-347946-i6kx3n6m 360 25 Europeans Europeans NNPS cord-347946-i6kx3n6m 360 26 as as IN cord-347946-i6kx3n6m 360 27 a a DT cord-347946-i6kx3n6m 360 28 result result NN cord-347946-i6kx3n6m 360 29 of of IN cord-347946-i6kx3n6m 360 30 positive positive JJ cord-347946-i6kx3n6m 360 31 selection selection NN cord-347946-i6kx3n6m 360 32 , , , cord-347946-i6kx3n6m 360 33 and and CC cord-347946-i6kx3n6m 360 34 this this DT cord-347946-i6kx3n6m 360 35 is be VBZ cord-347946-i6kx3n6m 360 36 indeed indeed RB cord-347946-i6kx3n6m 360 37 the the DT cord-347946-i6kx3n6m 360 38 case case NN cord-347946-i6kx3n6m 360 39 ( ( -LRB- cord-347946-i6kx3n6m 360 40 Consortium Consortium NNP cord-347946-i6kx3n6m 360 41 C C NNP cord-347946-i6kx3n6m 360 42 ( ( -LRB- cord-347946-i6kx3n6m 360 43 2015 2015 CD cord-347946-i6kx3n6m 360 44 ) ) -RRB- cord-347946-i6kx3n6m 360 45 . . . cord-347946-i6kx3n6m 361 1 Many many JJ cord-347946-i6kx3n6m 361 2 genes gene NNS cord-347946-i6kx3n6m 361 3 have have VBP cord-347946-i6kx3n6m 361 4 been be VBN cord-347946-i6kx3n6m 361 5 replicated replicate VBN cord-347946-i6kx3n6m 361 6 across across IN cord-347946-i6kx3n6m 361 7 a a DT cord-347946-i6kx3n6m 361 8 range range NN cord-347946-i6kx3n6m 361 9 of of IN cord-347946-i6kx3n6m 361 10 ethnic/ ethnic/ CD cord-347946-i6kx3n6m 361 11 racial racial JJ cord-347946-i6kx3n6m 361 12 groups group NNS cord-347946-i6kx3n6m 361 13 as as IN cord-347946-i6kx3n6m 361 14 risk risk NN cord-347946-i6kx3n6m 361 15 factors factor NNS cord-347946-i6kx3n6m 361 16 for for IN cord-347946-i6kx3n6m 361 17 schizophrenia schizophrenia NN cord-347946-i6kx3n6m 361 18 , , , cord-347946-i6kx3n6m 361 19 suggesting suggest VBG cord-347946-i6kx3n6m 361 20 that that IN cord-347946-i6kx3n6m 361 21 at at IN cord-347946-i6kx3n6m 361 22 least least JJS cord-347946-i6kx3n6m 361 23 certain certain JJ cord-347946-i6kx3n6m 361 24 pathways pathway NNS cord-347946-i6kx3n6m 361 25 for for IN cord-347946-i6kx3n6m 361 26 the the DT cord-347946-i6kx3n6m 361 27 disorder disorder NN cord-347946-i6kx3n6m 361 28 are be VBP cord-347946-i6kx3n6m 361 29 ancient ancient JJ cord-347946-i6kx3n6m 361 30 and and CC cord-347946-i6kx3n6m 361 31 arose arise VBD cord-347946-i6kx3n6m 361 32 prior prior RB cord-347946-i6kx3n6m 361 33 to to IN cord-347946-i6kx3n6m 361 34 the the DT cord-347946-i6kx3n6m 361 35 first first JJ cord-347946-i6kx3n6m 361 36 migrations migration NNS cord-347946-i6kx3n6m 361 37 of of IN cord-347946-i6kx3n6m 361 38 modern modern JJ cord-347946-i6kx3n6m 361 39 humans human NNS cord-347946-i6kx3n6m 361 40 out out IN cord-347946-i6kx3n6m 361 41 of of IN cord-347946-i6kx3n6m 361 42 Africa Africa NNP cord-347946-i6kx3n6m 361 43 . . . cord-347946-i6kx3n6m 362 1 From from IN cord-347946-i6kx3n6m 362 2 a a DT cord-347946-i6kx3n6m 362 3 PATHOS pathos NN cord-347946-i6kx3n6m 362 4 - - HYPH cord-347946-i6kx3n6m 362 5 D d JJ cord-347946-i6kx3n6m 362 6 perspective perspective NN cord-347946-i6kx3n6m 362 7 , , , cord-347946-i6kx3n6m 362 8 the the DT cord-347946-i6kx3n6m 362 9 fact fact NN cord-347946-i6kx3n6m 362 10 that that IN cord-347946-i6kx3n6m 362 11 no no DT cord-347946-i6kx3n6m 362 12 such such JJ cord-347946-i6kx3n6m 362 13 replicated replicate VBN cord-347946-i6kx3n6m 362 14 risk risk NN cord-347946-i6kx3n6m 362 15 alleles allele NNS cord-347946-i6kx3n6m 362 16 have have VBP cord-347946-i6kx3n6m 362 17 been be VBN cord-347946-i6kx3n6m 362 18 found find VBN cord-347946-i6kx3n6m 362 19 for for IN cord-347946-i6kx3n6m 362 20 MDD MDD NNP cord-347946-i6kx3n6m 362 21 may may MD cord-347946-i6kx3n6m 362 22 suggest suggest VB cord-347946-i6kx3n6m 362 23 that that IN cord-347946-i6kx3n6m 362 24 the the DT cord-347946-i6kx3n6m 362 25 condition condition NN cord-347946-i6kx3n6m 362 26 is be VBZ cord-347946-i6kx3n6m 362 27 more more RBR cord-347946-i6kx3n6m 362 28 environmentally environmentally RB cord-347946-i6kx3n6m 362 29 based base VBN cord-347946-i6kx3n6m 362 30 than than IN cord-347946-i6kx3n6m 362 31 are be VBP cord-347946-i6kx3n6m 362 32 conditions condition NNS cord-347946-i6kx3n6m 362 33 with with IN cord-347946-i6kx3n6m 362 34 more more RBR cord-347946-i6kx3n6m 362 35 universally universally RB cord-347946-i6kx3n6m 362 36 established established JJ cord-347946-i6kx3n6m 362 37 genetic genetic JJ cord-347946-i6kx3n6m 362 38 risk risk NN cord-347946-i6kx3n6m 362 39 genes gene NNS cord-347946-i6kx3n6m 362 40 , , , cord-347946-i6kx3n6m 362 41 but but CC cord-347946-i6kx3n6m 362 42 not not RB cord-347946-i6kx3n6m 362 43 in in IN cord-347946-i6kx3n6m 362 44 the the DT cord-347946-i6kx3n6m 362 45 way way NN cord-347946-i6kx3n6m 362 46 that that WDT cord-347946-i6kx3n6m 362 47 this this DT cord-347946-i6kx3n6m 362 48 environmental environmental JJ cord-347946-i6kx3n6m 362 49 primacy primacy NN cord-347946-i6kx3n6m 362 50 is be VBZ cord-347946-i6kx3n6m 362 51 usually usually RB cord-347946-i6kx3n6m 362 52 understood understand VBN cord-347946-i6kx3n6m 362 53 . . . cord-347946-i6kx3n6m 363 1 Instead instead RB cord-347946-i6kx3n6m 363 2 , , , cord-347946-i6kx3n6m 363 3 MDD MDD NNP cord-347946-i6kx3n6m 363 4 may may MD cord-347946-i6kx3n6m 363 5 have have VB cord-347946-i6kx3n6m 363 6 no no DT cord-347946-i6kx3n6m 363 7 universal universal JJ cord-347946-i6kx3n6m 363 8 risk risk NN cord-347946-i6kx3n6m 363 9 genes gene NNS cord-347946-i6kx3n6m 363 10 because because IN cord-347946-i6kx3n6m 363 11 pathogen pathogen NN cord-347946-i6kx3n6m 363 12 pressures pressure NNS cord-347946-i6kx3n6m 363 13 in in IN cord-347946-i6kx3n6m 363 14 local local JJ cord-347946-i6kx3n6m 363 15 environments environment NNS cord-347946-i6kx3n6m 363 16 over over IN cord-347946-i6kx3n6m 363 17 the the DT cord-347946-i6kx3n6m 363 18 last last JJ cord-347946-i6kx3n6m 363 19 60 60 CD cord-347946-i6kx3n6m 363 20 000 000 CD cord-347946-i6kx3n6m 363 21 years year NNS cord-347946-i6kx3n6m 363 22 have have VBP cord-347946-i6kx3n6m 363 23 been be VBN cord-347946-i6kx3n6m 363 24 pre pre JJ cord-347946-i6kx3n6m 363 25 - - JJ cord-347946-i6kx3n6m 363 26 eminent eminent JJ cord-347946-i6kx3n6m 363 27 in in IN cord-347946-i6kx3n6m 363 28 determining determine VBG cord-347946-i6kx3n6m 363 29 which which WDT cord-347946-i6kx3n6m 363 30 specific specific JJ cord-347946-i6kx3n6m 363 31 immune immune JJ cord-347946-i6kx3n6m 363 32 mechanisms mechanism NNS cord-347946-i6kx3n6m 363 33 were be VBD cord-347946-i6kx3n6m 363 34 most most RBS cord-347946-i6kx3n6m 363 35 adaptively adaptively RB cord-347946-i6kx3n6m 363 36 linked link VBN cord-347946-i6kx3n6m 363 37 to to IN cord-347946-i6kx3n6m 363 38 the the DT cord-347946-i6kx3n6m 363 39 generation generation NN cord-347946-i6kx3n6m 363 40 of of IN cord-347946-i6kx3n6m 363 41 depressive depressive JJ cord-347946-i6kx3n6m 363 42 symptoms symptom NNS cord-347946-i6kx3n6m 363 43 in in IN cord-347946-i6kx3n6m 363 44 any any DT cord-347946-i6kx3n6m 363 45 given give VBN cord-347946-i6kx3n6m 363 46 environment environment NN cord-347946-i6kx3n6m 363 47 . . . cord-347946-i6kx3n6m 364 1 If if IN cord-347946-i6kx3n6m 364 2 it -PRON- PRP cord-347946-i6kx3n6m 364 3 turns turn VBZ cord-347946-i6kx3n6m 364 4 out out RP cord-347946-i6kx3n6m 364 5 that that IN cord-347946-i6kx3n6m 364 6 the the DT cord-347946-i6kx3n6m 364 7 association association NN cord-347946-i6kx3n6m 364 8 between between IN cord-347946-i6kx3n6m 364 9 depression depression NN cord-347946-i6kx3n6m 364 10 and and CC cord-347946-i6kx3n6m 364 11 increased increase VBN cord-347946-i6kx3n6m 364 12 inflammation inflammation NN cord-347946-i6kx3n6m 364 13 is be VBZ cord-347946-i6kx3n6m 364 14 a a DT cord-347946-i6kx3n6m 364 15 human human JJ cord-347946-i6kx3n6m 364 16 universal universal NN cord-347946-i6kx3n6m 364 17 ( ( -LRB- cord-347946-i6kx3n6m 364 18 not not RB cord-347946-i6kx3n6m 364 19 universal universal JJ cord-347946-i6kx3n6m 364 20 in in IN cord-347946-i6kx3n6m 364 21 terms term NNS cord-347946-i6kx3n6m 364 22 of of IN cord-347946-i6kx3n6m 364 23 all all DT cord-347946-i6kx3n6m 364 24 depressed depressed JJ cord-347946-i6kx3n6m 364 25 individuals individual NNS cord-347946-i6kx3n6m 364 26 showing show VBG cord-347946-i6kx3n6m 364 27 increased increase VBN cord-347946-i6kx3n6m 364 28 inflammation inflammation NN cord-347946-i6kx3n6m 364 29 , , , cord-347946-i6kx3n6m 364 30 but but CC cord-347946-i6kx3n6m 364 31 rather rather RB cord-347946-i6kx3n6m 364 32 that that IN cord-347946-i6kx3n6m 364 33 groups group NNS cord-347946-i6kx3n6m 364 34 of of IN cord-347946-i6kx3n6m 364 35 depressed depressed JJ cord-347946-i6kx3n6m 364 36 individuals individual NNS cord-347946-i6kx3n6m 364 37 demonstrate demonstrate VBP cord-347946-i6kx3n6m 364 38 increased increase VBN cord-347946-i6kx3n6m 364 39 inflammation inflammation NN cord-347946-i6kx3n6m 364 40 across across IN cord-347946-i6kx3n6m 364 41 all all DT cord-347946-i6kx3n6m 364 42 ethnicities ethnicity NNS cord-347946-i6kx3n6m 364 43 / / SYM cord-347946-i6kx3n6m 364 44 cultures culture NNS cord-347946-i6kx3n6m 364 45 ) ) -RRB- cord-347946-i6kx3n6m 364 46 , , , cord-347946-i6kx3n6m 364 47 then then RB cord-347946-i6kx3n6m 364 48 the the DT cord-347946-i6kx3n6m 364 49 clear clear JJ cord-347946-i6kx3n6m 364 50 prediction prediction NN cord-347946-i6kx3n6m 364 51 of of IN cord-347946-i6kx3n6m 364 52 PATHOS pathos NN cord-347946-i6kx3n6m 364 53 - - HYPH cord-347946-i6kx3n6m 364 54 D D NNP cord-347946-i6kx3n6m 364 55 would would MD cord-347946-i6kx3n6m 364 56 be be VB cord-347946-i6kx3n6m 364 57 that that IN cord-347946-i6kx3n6m 364 58 alleles allele NNS cord-347946-i6kx3n6m 364 59 that that WDT cord-347946-i6kx3n6m 364 60 confer confer VBP cord-347946-i6kx3n6m 364 61 depression depression NN cord-347946-i6kx3n6m 364 62 risk risk NN cord-347946-i6kx3n6m 364 63 in in IN cord-347946-i6kx3n6m 364 64 one one CD cord-347946-i6kx3n6m 364 65 population population NN cord-347946-i6kx3n6m 364 66 but but CC cord-347946-i6kx3n6m 364 67 not not RB cord-347946-i6kx3n6m 364 68 another another DT cord-347946-i6kx3n6m 364 69 should should MD cord-347946-i6kx3n6m 364 70 either either CC cord-347946-i6kx3n6m 364 71 ( ( -LRB- cord-347946-i6kx3n6m 364 72 1 1 LS cord-347946-i6kx3n6m 364 73 ) ) -RRB- cord-347946-i6kx3n6m 364 74 increase increase VB cord-347946-i6kx3n6m 364 75 inflammatory inflammatory JJ cord-347946-i6kx3n6m 364 76 signaling signal VBG cord-347946-i6kx3n6m 364 77 more more RBR cord-347946-i6kx3n6m 364 78 in in IN cord-347946-i6kx3n6m 364 79 the the DT cord-347946-i6kx3n6m 364 80 population population NN cord-347946-i6kx3n6m 364 81 in in IN cord-347946-i6kx3n6m 364 82 which which WDT cord-347946-i6kx3n6m 364 83 they -PRON- PRP cord-347946-i6kx3n6m 364 84 confer confer VBP cord-347946-i6kx3n6m 364 85 risk risk NN cord-347946-i6kx3n6m 364 86 ; ; : cord-347946-i6kx3n6m 364 87 or or CC cord-347946-i6kx3n6m 364 88 ( ( -LRB- cord-347946-i6kx3n6m 364 89 2 2 LS cord-347946-i6kx3n6m 364 90 ) ) -RRB- cord-347946-i6kx3n6m 364 91 more more RBR cord-347946-i6kx3n6m 364 92 powerfully powerfully RB cord-347946-i6kx3n6m 364 93 increase increase VB cord-347946-i6kx3n6m 364 94 the the DT cord-347946-i6kx3n6m 364 95 prevalence/ prevalence/ NN cord-347946-i6kx3n6m 364 96 severity severity NN cord-347946-i6kx3n6m 364 97 of of IN cord-347946-i6kx3n6m 364 98 depressive depressive JJ cord-347946-i6kx3n6m 364 99 symptoms symptom NNS cord-347946-i6kx3n6m 364 100 in in IN cord-347946-i6kx3n6m 364 101 response response NN cord-347946-i6kx3n6m 364 102 to to IN cord-347946-i6kx3n6m 364 103 any any DT cord-347946-i6kx3n6m 364 104 given give VBN cord-347946-i6kx3n6m 364 105 degree degree NN cord-347946-i6kx3n6m 364 106 of of IN cord-347946-i6kx3n6m 364 107 inflammatory inflammatory JJ cord-347946-i6kx3n6m 364 108 activity activity NN cord-347946-i6kx3n6m 364 109 in in IN cord-347946-i6kx3n6m 364 110 the the DT cord-347946-i6kx3n6m 364 111 population population NN cord-347946-i6kx3n6m 364 112 in in IN cord-347946-i6kx3n6m 364 113 which which WDT cord-347946-i6kx3n6m 364 114 they -PRON- PRP cord-347946-i6kx3n6m 364 115 confer confer VBP cord-347946-i6kx3n6m 364 116 risk risk NN cord-347946-i6kx3n6m 364 117 . . . cord-347946-i6kx3n6m 365 1 Similarly similarly RB cord-347946-i6kx3n6m 365 2 , , , cord-347946-i6kx3n6m 365 3 because because IN cord-347946-i6kx3n6m 365 4 present present JJ cord-347946-i6kx3n6m 365 5 - - HYPH cord-347946-i6kx3n6m 365 6 day day NN cord-347946-i6kx3n6m 365 7 human human JJ cord-347946-i6kx3n6m 365 8 societies society NNS cord-347946-i6kx3n6m 365 9 / / SYM cord-347946-i6kx3n6m 365 10 cultural cultural JJ cord-347946-i6kx3n6m 365 11 groups group NNS cord-347946-i6kx3n6m 365 12 have have VBP cord-347946-i6kx3n6m 365 13 historically historically RB cord-347946-i6kx3n6m 365 14 experienced experience VBN cord-347946-i6kx3n6m 365 15 widely widely RB cord-347946-i6kx3n6m 365 16 different different JJ cord-347946-i6kx3n6m 365 17 degrees degree NNS cord-347946-i6kx3n6m 365 18 of of IN cord-347946-i6kx3n6m 365 19 exposure exposure NN cord-347946-i6kx3n6m 365 20 to to IN cord-347946-i6kx3n6m 365 21 bacterial bacterial JJ cord-347946-i6kx3n6m 365 22 and and CC cord-347946-i6kx3n6m 365 23 viral viral JJ cord-347946-i6kx3n6m 365 24 pandemics pandemic NNS cord-347946-i6kx3n6m 365 25 that that WDT cord-347946-i6kx3n6m 365 26 exerted exert VBD cord-347946-i6kx3n6m 365 27 extreme extreme JJ cord-347946-i6kx3n6m 365 28 selective selective JJ cord-347946-i6kx3n6m 365 29 pressure pressure NN cord-347946-i6kx3n6m 365 30 ( ( -LRB- cord-347946-i6kx3n6m 365 31 Fincher Fincher NNP cord-347946-i6kx3n6m 365 32 et et NNP cord-347946-i6kx3n6m 365 33 al al NNP cord-347946-i6kx3n6m 365 34 , , , cord-347946-i6kx3n6m 365 35 2008 2008 CD cord-347946-i6kx3n6m 365 36 ) ) -RRB- cord-347946-i6kx3n6m 365 37 , , , cord-347946-i6kx3n6m 365 38 PATHOS pathos NN cord-347946-i6kx3n6m 365 39 - - HYPH cord-347946-i6kx3n6m 365 40 D D NNP cord-347946-i6kx3n6m 365 41 predicts predict VBZ cord-347946-i6kx3n6m 365 42 that that IN cord-347946-i6kx3n6m 365 43 the the DT cord-347946-i6kx3n6m 365 44 types type NNS cord-347946-i6kx3n6m 365 45 of of IN cord-347946-i6kx3n6m 365 46 immunity immunity NN cord-347946-i6kx3n6m 365 47 that that WDT cord-347946-i6kx3n6m 365 48 best good JJS cord-347946-i6kx3n6m 365 49 cope cope VBP cord-347946-i6kx3n6m 365 50 with with IN cord-347946-i6kx3n6m 365 51 these these DT cord-347946-i6kx3n6m 365 52 different different JJ cord-347946-i6kx3n6m 365 53 types type NNS cord-347946-i6kx3n6m 365 54 of of IN cord-347946-i6kx3n6m 365 55 pathogens pathogen NNS cord-347946-i6kx3n6m 365 56 should should MD cord-347946-i6kx3n6m 365 57 have have VB cord-347946-i6kx3n6m 365 58 different different JJ cord-347946-i6kx3n6m 365 59 relationships relationship NNS cord-347946-i6kx3n6m 365 60 with with IN cord-347946-i6kx3n6m 365 61 depression depression NN cord-347946-i6kx3n6m 365 62 across across IN cord-347946-i6kx3n6m 365 63 human human JJ cord-347946-i6kx3n6m 365 64 cultures culture NNS cord-347946-i6kx3n6m 365 65 . . . cord-347946-i6kx3n6m 366 1 So so RB cord-347946-i6kx3n6m 366 2 , , , cord-347946-i6kx3n6m 366 3 for for IN cord-347946-i6kx3n6m 366 4 example example NN cord-347946-i6kx3n6m 366 5 , , , cord-347946-i6kx3n6m 366 6 because because IN cord-347946-i6kx3n6m 366 7 interferon interferon NN cord-347946-i6kx3n6m 366 8 signaling signaling NN cord-347946-i6kx3n6m 366 9 is be VBZ cord-347946-i6kx3n6m 366 10 especially especially RB cord-347946-i6kx3n6m 366 11 essential essential JJ cord-347946-i6kx3n6m 366 12 for for IN cord-347946-i6kx3n6m 366 13 host host NN cord-347946-i6kx3n6m 366 14 defense defense NN cord-347946-i6kx3n6m 366 15 against against IN cord-347946-i6kx3n6m 366 16 viruses virus NNS cord-347946-i6kx3n6m 366 17 , , , cord-347946-i6kx3n6m 366 18 a a DT cord-347946-i6kx3n6m 366 19 PATHOS pathos NN cord-347946-i6kx3n6m 366 20 - - HYPH cord-347946-i6kx3n6m 366 21 D d JJ cord-347946-i6kx3n6m 366 22 perspective perspective NN cord-347946-i6kx3n6m 366 23 would would MD cord-347946-i6kx3n6m 366 24 predict predict VB cord-347946-i6kx3n6m 366 25 that that IN cord-347946-i6kx3n6m 366 26 individuals individual NNS cord-347946-i6kx3n6m 366 27 from from IN cord-347946-i6kx3n6m 366 28 cultures culture NNS cord-347946-i6kx3n6m 366 29 with with IN cord-347946-i6kx3n6m 366 30 higher high JJR cord-347946-i6kx3n6m 366 31 rates rate NNS cord-347946-i6kx3n6m 366 32 of of IN cord-347946-i6kx3n6m 366 33 historical historical JJ cord-347946-i6kx3n6m 366 34 exposure exposure NN cord-347946-i6kx3n6m 366 35 to to IN cord-347946-i6kx3n6m 366 36 lethal lethal JJ cord-347946-i6kx3n6m 366 37 viral viral JJ cord-347946-i6kx3n6m 366 38 pandemics pandemic NNS cord-347946-i6kx3n6m 366 39 should should MD cord-347946-i6kx3n6m 366 40 respond respond VB cord-347946-i6kx3n6m 366 41 to to IN cord-347946-i6kx3n6m 366 42 treatment treatment NN cord-347946-i6kx3n6m 366 43 with with IN cord-347946-i6kx3n6m 366 44 IFN IFN NNP cord-347946-i6kx3n6m 366 45 - - HYPH cord-347946-i6kx3n6m 366 46 α α NN cord-347946-i6kx3n6m 366 47 with with IN cord-347946-i6kx3n6m 366 48 increased increase VBN cord-347946-i6kx3n6m 366 49 rates rate NNS cord-347946-i6kx3n6m 366 50 of of IN cord-347946-i6kx3n6m 366 51 depression depression NN cord-347946-i6kx3n6m 366 52 development development NN cord-347946-i6kx3n6m 366 53 , , , cord-347946-i6kx3n6m 366 54 if if IN cord-347946-i6kx3n6m 366 55 indeed indeed RB cord-347946-i6kx3n6m 366 56 depressive depressive JJ cord-347946-i6kx3n6m 366 57 symptoms symptom NNS cord-347946-i6kx3n6m 366 58 aid aid VBP cord-347946-i6kx3n6m 366 59 in in IN cord-347946-i6kx3n6m 366 60 pathogen pathogen NN cord-347946-i6kx3n6m 366 61 defense defense NN cord-347946-i6kx3n6m 366 62 . . . cord-347946-i6kx3n6m 367 1 Were be VBD cord-347946-i6kx3n6m 367 2 it -PRON- PRP cord-347946-i6kx3n6m 367 3 possible possible JJ cord-347946-i6kx3n6m 367 4 to to TO cord-347946-i6kx3n6m 367 5 assess assess VB cord-347946-i6kx3n6m 367 6 , , , cord-347946-i6kx3n6m 367 7 this this DT cord-347946-i6kx3n6m 367 8 effect effect NN cord-347946-i6kx3n6m 367 9 should should MD cord-347946-i6kx3n6m 367 10 be be VB cord-347946-i6kx3n6m 367 11 largest large JJS cord-347946-i6kx3n6m 367 12 in in IN cord-347946-i6kx3n6m 367 13 hunter hunter NN cord-347946-i6kx3n6m 367 14 - - HYPH cord-347946-i6kx3n6m 367 15 gatherer gatherer NN cord-347946-i6kx3n6m 367 16 populations population NNS cord-347946-i6kx3n6m 367 17 that that WDT cord-347946-i6kx3n6m 367 18 have have VBP cord-347946-i6kx3n6m 367 19 evolved evolve VBN cord-347946-i6kx3n6m 367 20 in in IN cord-347946-i6kx3n6m 367 21 the the DT cord-347946-i6kx3n6m 367 22 types type NNS cord-347946-i6kx3n6m 367 23 of of IN cord-347946-i6kx3n6m 367 24 low low JJ cord-347946-i6kx3n6m 367 25 population population NN cord-347946-i6kx3n6m 367 26 density density NN cord-347946-i6kx3n6m 367 27 environments environment NNS cord-347946-i6kx3n6m 367 28 that that WDT cord-347946-i6kx3n6m 367 29 work work VBP cord-347946-i6kx3n6m 367 30 against against IN cord-347946-i6kx3n6m 367 31 widespread widespread JJ cord-347946-i6kx3n6m 367 32 viral viral JJ cord-347946-i6kx3n6m 367 33 infections infection NNS cord-347946-i6kx3n6m 367 34 . . . cord-347946-i6kx3n6m 368 1 In in IN cord-347946-i6kx3n6m 368 2 such such JJ cord-347946-i6kx3n6m 368 3 populations population NNS cord-347946-i6kx3n6m 368 4 , , , cord-347946-i6kx3n6m 368 5 viruses virus NNS cord-347946-i6kx3n6m 368 6 provided provide VBD cord-347946-i6kx3n6m 368 7 little little JJ cord-347946-i6kx3n6m 368 8 positive positive JJ cord-347946-i6kx3n6m 368 9 selection selection NN cord-347946-i6kx3n6m 368 10 pressure pressure NN cord-347946-i6kx3n6m 368 11 that that WDT cord-347946-i6kx3n6m 368 12 would would MD cord-347946-i6kx3n6m 368 13 link link VB cord-347946-i6kx3n6m 368 14 antiviral antiviral JJ cord-347946-i6kx3n6m 368 15 defenses defense NNS cord-347946-i6kx3n6m 368 16 with with IN cord-347946-i6kx3n6m 368 17 depression depression NN cord-347946-i6kx3n6m 368 18 , , , cord-347946-i6kx3n6m 368 19 whereas whereas IN cord-347946-i6kx3n6m 368 20 such such JJ cord-347946-i6kx3n6m 368 21 populations population NNS cord-347946-i6kx3n6m 368 22 would would MD cord-347946-i6kx3n6m 368 23 have have VB cord-347946-i6kx3n6m 368 24 benefitted benefit VBN cord-347946-i6kx3n6m 368 25 from from IN cord-347946-i6kx3n6m 368 26 optimal optimal JJ cord-347946-i6kx3n6m 368 27 protection protection NN cord-347946-i6kx3n6m 368 28 against against IN cord-347946-i6kx3n6m 368 29 environmental environmental JJ cord-347946-i6kx3n6m 368 30 pathogens pathogen NNS cord-347946-i6kx3n6m 368 31 ( ( -LRB- cord-347946-i6kx3n6m 368 32 eg eg RB cord-347946-i6kx3n6m 368 33 , , , cord-347946-i6kx3n6m 368 34 protozoa protozoan NNS cord-347946-i6kx3n6m 368 35 , , , cord-347946-i6kx3n6m 368 36 bacteria bacteria NNS cord-347946-i6kx3n6m 368 37 , , , cord-347946-i6kx3n6m 368 38 and and CC cord-347946-i6kx3n6m 368 39 fungi fungus NNS cord-347946-i6kx3n6m 368 40 ) ) -RRB- cord-347946-i6kx3n6m 368 41 that that WDT cord-347946-i6kx3n6m 368 42 would would MD cord-347946-i6kx3n6m 368 43 have have VB cord-347946-i6kx3n6m 368 44 increased increase VBN cord-347946-i6kx3n6m 368 45 mortality mortality NN cord-347946-i6kx3n6m 368 46 under under IN cord-347946-i6kx3n6m 368 47 these these DT cord-347946-i6kx3n6m 368 48 conditions condition NNS cord-347946-i6kx3n6m 368 49 . . . cord-347946-i6kx3n6m 369 1 Were be VBD cord-347946-i6kx3n6m 369 2 such such PDT cord-347946-i6kx3n6m 369 3 a a DT cord-347946-i6kx3n6m 369 4 population population NN cord-347946-i6kx3n6m 369 5 available available JJ cord-347946-i6kx3n6m 369 6 , , , cord-347946-i6kx3n6m 369 7 the the DT cord-347946-i6kx3n6m 369 8 prediction prediction NN cord-347946-i6kx3n6m 369 9 is be VBZ cord-347946-i6kx3n6m 369 10 that that IN cord-347946-i6kx3n6m 369 11 they -PRON- PRP cord-347946-i6kx3n6m 369 12 would would MD cord-347946-i6kx3n6m 369 13 show show VB cord-347946-i6kx3n6m 369 14 enhanced enhance VBN cord-347946-i6kx3n6m 369 15 depressive depressive JJ cord-347946-i6kx3n6m 369 16 symptoms symptom NNS cord-347946-i6kx3n6m 369 17 in in IN cord-347946-i6kx3n6m 369 18 response response NN cord-347946-i6kx3n6m 369 19 to to IN cord-347946-i6kx3n6m 369 20 a a DT cord-347946-i6kx3n6m 369 21 bacterial bacterial JJ cord-347946-i6kx3n6m 369 22 stimulant stimulant NN cord-347946-i6kx3n6m 369 23 such such JJ cord-347946-i6kx3n6m 369 24 as as IN cord-347946-i6kx3n6m 369 25 endotoxin endotoxin NN cord-347946-i6kx3n6m 369 26 , , , cord-347946-i6kx3n6m 369 27 while while IN cord-347946-i6kx3n6m 369 28 showing show VBG cord-347946-i6kx3n6m 369 29 a a DT cord-347946-i6kx3n6m 369 30 muted muted JJ cord-347946-i6kx3n6m 369 31 depressive depressive JJ cord-347946-i6kx3n6m 369 32 response response NN cord-347946-i6kx3n6m 369 33 to to IN cord-347946-i6kx3n6m 369 34 IFN IFN NNP cord-347946-i6kx3n6m 369 35 - - HYPH cord-347946-i6kx3n6m 369 36 α α NNP cord-347946-i6kx3n6m 369 37 . . . cord-347946-i6kx3n6m 370 1 Alas alas UH cord-347946-i6kx3n6m 370 2 , , , cord-347946-i6kx3n6m 370 3 given give VBN cord-347946-i6kx3n6m 370 4 the the DT cord-347946-i6kx3n6m 370 5 escalating escalate VBG cord-347946-i6kx3n6m 370 6 loss loss NN cord-347946-i6kx3n6m 370 7 of of IN cord-347946-i6kx3n6m 370 8 isolated isolate VBN cord-347946-i6kx3n6m 370 9 indigenous indigenous JJ cord-347946-i6kx3n6m 370 10 cultures culture NNS cord-347946-i6kx3n6m 370 11 , , , cord-347946-i6kx3n6m 370 12 the the DT cord-347946-i6kx3n6m 370 13 time time NN cord-347946-i6kx3n6m 370 14 for for IN cord-347946-i6kx3n6m 370 15 such such PDT cord-347946-i6kx3n6m 370 16 a a DT cord-347946-i6kx3n6m 370 17 definitive definitive JJ cord-347946-i6kx3n6m 370 18 study study NN cord-347946-i6kx3n6m 370 19 may may MD cord-347946-i6kx3n6m 370 20 have have VB cord-347946-i6kx3n6m 370 21 passed pass VBN cord-347946-i6kx3n6m 370 22 . . . cord-347946-i6kx3n6m 371 1 Adaptive adaptive JJ cord-347946-i6kx3n6m 371 2 introgression introgression NN cord-347946-i6kx3n6m 371 3 provides provide VBZ cord-347946-i6kx3n6m 371 4 another another DT cord-347946-i6kx3n6m 371 5 fascinating fascinating JJ cord-347946-i6kx3n6m 371 6 example example NN cord-347946-i6kx3n6m 371 7 of of IN cord-347946-i6kx3n6m 371 8 why why WRB cord-347946-i6kx3n6m 371 9 pathogen pathogen NN cord-347946-i6kx3n6m 371 10 - - HYPH cord-347946-i6kx3n6m 371 11 host host NN cord-347946-i6kx3n6m 371 12 defense defense NN cord-347946-i6kx3n6m 371 13 processes process NNS cord-347946-i6kx3n6m 371 14 may may MD cord-347946-i6kx3n6m 371 15 ensure ensure VB cord-347946-i6kx3n6m 371 16 that that IN cord-347946-i6kx3n6m 371 17 no no DT cord-347946-i6kx3n6m 371 18 universal universal JJ cord-347946-i6kx3n6m 371 19 genes gene NNS cord-347946-i6kx3n6m 371 20 for for IN cord-347946-i6kx3n6m 371 21 MDD MDD NNP cord-347946-i6kx3n6m 371 22 will will MD cord-347946-i6kx3n6m 371 23 ever ever RB cord-347946-i6kx3n6m 371 24 be be VB cord-347946-i6kx3n6m 371 25 found find VBN cord-347946-i6kx3n6m 371 26 . . . cord-347946-i6kx3n6m 372 1 Research research NN cord-347946-i6kx3n6m 372 2 over over IN cord-347946-i6kx3n6m 372 3 the the DT cord-347946-i6kx3n6m 372 4 last last JJ cord-347946-i6kx3n6m 372 5 several several JJ cord-347946-i6kx3n6m 372 6 years year NNS cord-347946-i6kx3n6m 372 7 indicates indicate VBZ cord-347946-i6kx3n6m 372 8 that~2 that~2 NNS cord-347946-i6kx3n6m 372 9 % % NN cord-347946-i6kx3n6m 372 10 of of IN cord-347946-i6kx3n6m 372 11 the the DT cord-347946-i6kx3n6m 372 12 DNA dna NN cord-347946-i6kx3n6m 372 13 of of IN cord-347946-i6kx3n6m 372 14 non non JJ cord-347946-i6kx3n6m 372 15 - - JJ cord-347946-i6kx3n6m 372 16 African african JJ cord-347946-i6kx3n6m 372 17 humans human NNS cord-347946-i6kx3n6m 372 18 derives derive VBZ cord-347946-i6kx3n6m 372 19 from from IN cord-347946-i6kx3n6m 372 20 multiple multiple JJ cord-347946-i6kx3n6m 372 21 bouts bout NNS cord-347946-i6kx3n6m 372 22 of of IN cord-347946-i6kx3n6m 372 23 interbreeding interbreed VBG cord-347946-i6kx3n6m 372 24 with with IN cord-347946-i6kx3n6m 372 25 Neanderthals Neanderthals NNPS cord-347946-i6kx3n6m 372 26 , , , cord-347946-i6kx3n6m 372 27 with with IN cord-347946-i6kx3n6m 372 28 current current JJ cord-347946-i6kx3n6m 372 29 Melanesian melanesian JJ cord-347946-i6kx3n6m 372 30 populations population NNS cord-347946-i6kx3n6m 372 31 also also RB cord-347946-i6kx3n6m 372 32 showing show VBG cord-347946-i6kx3n6m 372 33 a a DT cord-347946-i6kx3n6m 372 34 Denisovan Denisovan NNP cord-347946-i6kx3n6m 372 35 genetic genetic JJ cord-347946-i6kx3n6m 372 36 inheritance inheritance NN cord-347946-i6kx3n6m 372 37 from from IN cord-347946-i6kx3n6m 372 38 ancestral ancestral JJ cord-347946-i6kx3n6m 372 39 interbreeding interbreeding NN cord-347946-i6kx3n6m 372 40 with with IN cord-347946-i6kx3n6m 372 41 that that DT cord-347946-i6kx3n6m 372 42 group group NN cord-347946-i6kx3n6m 372 43 of of IN cord-347946-i6kx3n6m 372 44 now now RB cord-347946-i6kx3n6m 372 45 - - HYPH cord-347946-i6kx3n6m 372 46 extinct extinct VBN cord-347946-i6kx3n6m 372 47 archaic archaic JJ cord-347946-i6kx3n6m 372 48 humans human NNS cord-347946-i6kx3n6m 372 49 . . . cord-347946-i6kx3n6m 373 1 In in IN cord-347946-i6kx3n6m 373 2 general general JJ cord-347946-i6kx3n6m 373 3 , , , cord-347946-i6kx3n6m 373 4 the the DT cord-347946-i6kx3n6m 373 5 results result NNS cord-347946-i6kx3n6m 373 6 of of IN cord-347946-i6kx3n6m 373 7 this this DT cord-347946-i6kx3n6m 373 8 interbreeding interbreeding NN cord-347946-i6kx3n6m 373 9 were be VBD cord-347946-i6kx3n6m 373 10 deleterious deleterious JJ cord-347946-i6kx3n6m 373 11 , , , cord-347946-i6kx3n6m 373 12 as as IN cord-347946-i6kx3n6m 373 13 attested attest VBN cord-347946-i6kx3n6m 373 14 to to IN cord-347946-i6kx3n6m 373 15 by by IN cord-347946-i6kx3n6m 373 16 multiple multiple JJ cord-347946-i6kx3n6m 373 17 ' ' `` cord-347946-i6kx3n6m 373 18 desert desert NN cord-347946-i6kx3n6m 373 19 ' ' '' cord-347946-i6kx3n6m 373 20 regions region NNS cord-347946-i6kx3n6m 373 21 of of IN cord-347946-i6kx3n6m 373 22 human human JJ cord-347946-i6kx3n6m 373 23 DNA dna NN cord-347946-i6kx3n6m 373 24 depleted deplete VBN cord-347946-i6kx3n6m 373 25 of of IN cord-347946-i6kx3n6m 373 26 archaic archaic JJ cord-347946-i6kx3n6m 373 27 genetic genetic JJ cord-347946-i6kx3n6m 373 28 material material NN cord-347946-i6kx3n6m 373 29 . . . cord-347946-i6kx3n6m 374 1 Against against IN cord-347946-i6kx3n6m 374 2 this this DT cord-347946-i6kx3n6m 374 3 backdrop backdrop NN cord-347946-i6kx3n6m 374 4 , , , cord-347946-i6kx3n6m 374 5 it -PRON- PRP cord-347946-i6kx3n6m 374 6 is be VBZ cord-347946-i6kx3n6m 374 7 striking strike VBG cord-347946-i6kx3n6m 374 8 that that IN cord-347946-i6kx3n6m 374 9 other other JJ cord-347946-i6kx3n6m 374 10 Neanderthal Neanderthal NNP cord-347946-i6kx3n6m 374 11 and and CC cord-347946-i6kx3n6m 374 12 Denisovan Denisovan NNP cord-347946-i6kx3n6m 374 13 sequences sequence NNS cord-347946-i6kx3n6m 374 14 appear appear VBP cord-347946-i6kx3n6m 374 15 to to TO cord-347946-i6kx3n6m 374 16 have have VB cord-347946-i6kx3n6m 374 17 undergone undergo VBN cord-347946-i6kx3n6m 374 18 positive positive JJ cord-347946-i6kx3n6m 374 19 selection selection NN cord-347946-i6kx3n6m 374 20 . . . cord-347946-i6kx3n6m 375 1 From from IN cord-347946-i6kx3n6m 375 2 a a DT cord-347946-i6kx3n6m 375 3 PATHOS pathos NN cord-347946-i6kx3n6m 375 4 - - HYPH cord-347946-i6kx3n6m 375 5 D d NN cord-347946-i6kx3n6m 375 6 perspective perspective NN cord-347946-i6kx3n6m 375 7 it -PRON- PRP cord-347946-i6kx3n6m 375 8 is be VBZ cord-347946-i6kx3n6m 375 9 even even RB cord-347946-i6kx3n6m 375 10 more more RBR cord-347946-i6kx3n6m 375 11 striking striking JJ cord-347946-i6kx3n6m 375 12 that that IN cord-347946-i6kx3n6m 375 13 these these DT cord-347946-i6kx3n6m 375 14 archaic archaic JJ cord-347946-i6kx3n6m 375 15 alleles allele NNS cord-347946-i6kx3n6m 375 16 are be VBP cord-347946-i6kx3n6m 375 17 associated associate VBN cord-347946-i6kx3n6m 375 18 with with IN cord-347946-i6kx3n6m 375 19 both both DT cord-347946-i6kx3n6m 375 20 immune immune JJ cord-347946-i6kx3n6m 375 21 function function NN cord-347946-i6kx3n6m 375 22 and and CC cord-347946-i6kx3n6m 375 23 with with IN cord-347946-i6kx3n6m 375 24 an an DT cord-347946-i6kx3n6m 375 25 increased increase VBN cord-347946-i6kx3n6m 375 26 risk risk NN cord-347946-i6kx3n6m 375 27 of of IN cord-347946-i6kx3n6m 375 28 depression depression NN cord-347946-i6kx3n6m 375 29 ( ( -LRB- cord-347946-i6kx3n6m 375 30 Mendez Mendez NNP cord-347946-i6kx3n6m 375 31 et et NNP cord-347946-i6kx3n6m 375 32 al al NNP cord-347946-i6kx3n6m 375 33 , , , cord-347946-i6kx3n6m 375 34 2012 2012 CD cord-347946-i6kx3n6m 375 35 ; ; : cord-347946-i6kx3n6m 375 36 Segurel Segurel NNP cord-347946-i6kx3n6m 375 37 and and CC cord-347946-i6kx3n6m 375 38 Quintana Quintana NNP cord-347946-i6kx3n6m 375 39 - - HYPH cord-347946-i6kx3n6m 375 40 Murci Murci NNP cord-347946-i6kx3n6m 375 41 , , , cord-347946-i6kx3n6m 375 42 2014 2014 CD cord-347946-i6kx3n6m 375 43 ; ; : cord-347946-i6kx3n6m 375 44 Simonti Simonti NNP cord-347946-i6kx3n6m 375 45 et et NNP cord-347946-i6kx3n6m 375 46 al al NNP cord-347946-i6kx3n6m 375 47 , , , cord-347946-i6kx3n6m 375 48 2016 2016 CD cord-347946-i6kx3n6m 375 49 ) ) -RRB- cord-347946-i6kx3n6m 375 50 . . . cord-347946-i6kx3n6m 376 1 Although although IN cord-347946-i6kx3n6m 376 2 it -PRON- PRP cord-347946-i6kx3n6m 376 3 does do VBZ cord-347946-i6kx3n6m 376 4 not not RB cord-347946-i6kx3n6m 376 5 yet yet RB cord-347946-i6kx3n6m 376 6 appear appear VB cord-347946-i6kx3n6m 376 7 that that IN cord-347946-i6kx3n6m 376 8 the the DT cord-347946-i6kx3n6m 376 9 same same JJ cord-347946-i6kx3n6m 376 10 Neanderthal neanderthal JJ cord-347946-i6kx3n6m 376 11 allelic allelic JJ cord-347946-i6kx3n6m 376 12 variants variant NNS cord-347946-i6kx3n6m 376 13 code code NN cord-347946-i6kx3n6m 376 14 for for IN cord-347946-i6kx3n6m 376 15 both both CC cord-347946-i6kx3n6m 376 16 immunity immunity NN cord-347946-i6kx3n6m 376 17 and and CC cord-347946-i6kx3n6m 376 18 mood mood NN cord-347946-i6kx3n6m 376 19 , , , cord-347946-i6kx3n6m 376 20 anyone anyone NN cord-347946-i6kx3n6m 376 21 concerned concern VBN cord-347946-i6kx3n6m 376 22 with with IN cord-347946-i6kx3n6m 376 23 adaptive adaptive JJ cord-347946-i6kx3n6m 376 24 explanations explanation NNS cord-347946-i6kx3n6m 376 25 for for IN cord-347946-i6kx3n6m 376 26 MDD MDD NNP cord-347946-i6kx3n6m 376 27 can can MD cord-347946-i6kx3n6m 376 28 not not RB cord-347946-i6kx3n6m 376 29 help help VB cord-347946-i6kx3n6m 376 30 but but CC cord-347946-i6kx3n6m 376 31 be be VB cord-347946-i6kx3n6m 376 32 struck strike VBN cord-347946-i6kx3n6m 376 33 by by IN cord-347946-i6kx3n6m 376 34 this this DT cord-347946-i6kx3n6m 376 35 association association NN cord-347946-i6kx3n6m 376 36 , , , cord-347946-i6kx3n6m 376 37 especially especially RB cord-347946-i6kx3n6m 376 38 given give VBN cord-347946-i6kx3n6m 376 39 that that DT cord-347946-i6kx3n6m 376 40 negative negative JJ cord-347946-i6kx3n6m 376 41 selection selection NN cord-347946-i6kx3n6m 376 42 appears appear VBZ cord-347946-i6kx3n6m 376 43 to to TO cord-347946-i6kx3n6m 376 44 have have VB cord-347946-i6kx3n6m 376 45 removed remove VBN cord-347946-i6kx3n6m 376 46 archaic archaic JJ cord-347946-i6kx3n6m 376 47 human human JJ cord-347946-i6kx3n6m 376 48 DNA dna NN cord-347946-i6kx3n6m 376 49 from from IN cord-347946-i6kx3n6m 376 50 areas area NNS cord-347946-i6kx3n6m 376 51 of of IN cord-347946-i6kx3n6m 376 52 the the DT cord-347946-i6kx3n6m 376 53 genome genome NN cord-347946-i6kx3n6m 376 54 involved involve VBN cord-347946-i6kx3n6m 376 55 with with IN cord-347946-i6kx3n6m 376 56 other other JJ cord-347946-i6kx3n6m 376 57 aspects aspect NNS cord-347946-i6kx3n6m 376 58 of of IN cord-347946-i6kx3n6m 376 59 CNS CNS NNP cord-347946-i6kx3n6m 376 60 morphology morphology NN cord-347946-i6kx3n6m 376 61 and and CC cord-347946-i6kx3n6m 376 62 function function NN cord-347946-i6kx3n6m 376 63 . . . cord-347946-i6kx3n6m 377 1 Researchers researcher NNS cord-347946-i6kx3n6m 377 2 tend tend VBP cord-347946-i6kx3n6m 377 3 to to TO cord-347946-i6kx3n6m 377 4 assume assume VB cord-347946-i6kx3n6m 377 5 that that IN cord-347946-i6kx3n6m 377 6 retained retain VBN cord-347946-i6kx3n6m 377 7 archaic archaic JJ cord-347946-i6kx3n6m 377 8 immune immune JJ cord-347946-i6kx3n6m 377 9 alleles allele NNS cord-347946-i6kx3n6m 377 10 provided provide VBD cord-347946-i6kx3n6m 377 11 an an DT cord-347946-i6kx3n6m 377 12 adaptive adaptive JJ cord-347946-i6kx3n6m 377 13 benefit benefit NN cord-347946-i6kx3n6m 377 14 for for IN cord-347946-i6kx3n6m 377 15 coping cope VBG cord-347946-i6kx3n6m 377 16 with with IN cord-347946-i6kx3n6m 377 17 novel novel JJ cord-347946-i6kx3n6m 377 18 Eurasian eurasian JJ cord-347946-i6kx3n6m 377 19 pathogens pathogen NNS cord-347946-i6kx3n6m 377 20 ; ; : cord-347946-i6kx3n6m 377 21 PATHOS pathos NN cord-347946-i6kx3n6m 377 22 - - HYPH cord-347946-i6kx3n6m 377 23 D D NNP cord-347946-i6kx3n6m 377 24 would would MD cord-347946-i6kx3n6m 377 25 suggest suggest VB cord-347946-i6kx3n6m 377 26 that that IN cord-347946-i6kx3n6m 377 27 their -PRON- PRP$ cord-347946-i6kx3n6m 377 28 proclivity proclivity NN cord-347946-i6kx3n6m 377 29 to to TO cord-347946-i6kx3n6m 377 30 induce induce VB cord-347946-i6kx3n6m 377 31 depression depression NN cord-347946-i6kx3n6m 377 32 provided provide VBD cord-347946-i6kx3n6m 377 33 additional additional JJ cord-347946-i6kx3n6m 377 34 advantages advantage NNS cord-347946-i6kx3n6m 377 35 in in IN cord-347946-i6kx3n6m 377 36 our -PRON- PRP$ cord-347946-i6kx3n6m 377 37 endless endless JJ cord-347946-i6kx3n6m 377 38 struggles struggle NNS cord-347946-i6kx3n6m 377 39 with with IN cord-347946-i6kx3n6m 377 40 microbes microbe NNS cord-347946-i6kx3n6m 377 41 and and CC cord-347946-i6kx3n6m 377 42 parasites parasite NNS cord-347946-i6kx3n6m 377 43 . . . cord-347946-i6kx3n6m 378 1 Here here RB cord-347946-i6kx3n6m 378 2 we -PRON- PRP cord-347946-i6kx3n6m 378 3 consider consider VBP cord-347946-i6kx3n6m 378 4 ways way NNS cord-347946-i6kx3n6m 378 5 in in IN cord-347946-i6kx3n6m 378 6 which which WDT cord-347946-i6kx3n6m 378 7 PATHOS pathos NN cord-347946-i6kx3n6m 378 8 - - HYPH cord-347946-i6kx3n6m 378 9 D D NNP cord-347946-i6kx3n6m 378 10 might may MD cord-347946-i6kx3n6m 378 11 provide provide VB cord-347946-i6kx3n6m 378 12 adaptive adaptive JJ cord-347946-i6kx3n6m 378 13 explanations explanation NNS cord-347946-i6kx3n6m 378 14 ( ( -LRB- cord-347946-i6kx3n6m 378 15 as as IN cord-347946-i6kx3n6m 378 16 opposed oppose VBN cord-347946-i6kx3n6m 378 17 to to IN cord-347946-i6kx3n6m 378 18 mere mere JJ cord-347946-i6kx3n6m 378 19 proximal/ proximal/ JJ cord-347946-i6kx3n6m 378 20 mechanistic mechanistic JJ cord-347946-i6kx3n6m 378 21 explanations explanation NNS cord-347946-i6kx3n6m 378 22 ) ) -RRB- cord-347946-i6kx3n6m 378 23 for for IN cord-347946-i6kx3n6m 378 24 three three CD cord-347946-i6kx3n6m 378 25 epidemiological epidemiological JJ cord-347946-i6kx3n6m 378 26 features feature NNS cord-347946-i6kx3n6m 378 27 of of IN cord-347946-i6kx3n6m 378 28 MDD MDD NNP cord-347946-i6kx3n6m 378 29 that that WDT cord-347946-i6kx3n6m 378 30 are be VBP cord-347946-i6kx3n6m 378 31 striking strike VBG cord-347946-i6kx3n6m 378 32 characteristics characteristic NNS cord-347946-i6kx3n6m 378 33 of of IN cord-347946-i6kx3n6m 378 34 the the DT cord-347946-i6kx3n6m 378 35 disorder disorder NN cord-347946-i6kx3n6m 378 36 and and CC cord-347946-i6kx3n6m 378 37 relate relate VBP cord-347946-i6kx3n6m 378 38 directly directly RB cord-347946-i6kx3n6m 378 39 to to IN cord-347946-i6kx3n6m 378 40 sex sex NN cord-347946-i6kx3n6m 378 41 : : : cord-347946-i6kx3n6m 378 42 ( ( -LRB- cord-347946-i6kx3n6m 378 43 1 1 LS cord-347946-i6kx3n6m 378 44 ) ) -RRB- cord-347946-i6kx3n6m 378 45 the the DT cord-347946-i6kx3n6m 378 46 2:1 2:1 CD cord-347946-i6kx3n6m 378 47 female female JJ cord-347946-i6kx3n6m 378 48 preponderance preponderance NN cord-347946-i6kx3n6m 378 49 of of IN cord-347946-i6kx3n6m 378 50 the the DT cord-347946-i6kx3n6m 378 51 disorder disorder NN cord-347946-i6kx3n6m 378 52 ; ; : cord-347946-i6kx3n6m 378 53 ( ( -LRB- cord-347946-i6kx3n6m 378 54 2 2 LS cord-347946-i6kx3n6m 378 55 ) ) -RRB- cord-347946-i6kx3n6m 378 56 the the DT cord-347946-i6kx3n6m 378 57 impact impact NN cord-347946-i6kx3n6m 378 58 of of IN cord-347946-i6kx3n6m 378 59 age age NN cord-347946-i6kx3n6m 378 60 and and CC cord-347946-i6kx3n6m 378 61 sex sex NN cord-347946-i6kx3n6m 378 62 on on IN cord-347946-i6kx3n6m 378 63 the the DT cord-347946-i6kx3n6m 378 64 disorder disorder NN cord-347946-i6kx3n6m 378 65 's 's POS cord-347946-i6kx3n6m 378 66 phenotypic phenotypic JJ cord-347946-i6kx3n6m 378 67 presentation presentation NN cord-347946-i6kx3n6m 378 68 ; ; , cord-347946-i6kx3n6m 378 69 and and CC cord-347946-i6kx3n6m 378 70 ( ( -LRB- cord-347946-i6kx3n6m 378 71 3 3 LS cord-347946-i6kx3n6m 378 72 ) ) -RRB- cord-347946-i6kx3n6m 378 73 the the DT cord-347946-i6kx3n6m 378 74 significant significant JJ cord-347946-i6kx3n6m 378 75 risk risk NN cord-347946-i6kx3n6m 378 76 of of IN cord-347946-i6kx3n6m 378 77 the the DT cord-347946-i6kx3n6m 378 78 postpartum postpartum NN cord-347946-i6kx3n6m 378 79 period period NN cord-347946-i6kx3n6m 378 80 for for IN cord-347946-i6kx3n6m 378 81 MDD MDD NNP cord-347946-i6kx3n6m 378 82 development development NN cord-347946-i6kx3n6m 378 83 . . . cord-347946-i6kx3n6m 379 1 Females female NNS cord-347946-i6kx3n6m 379 2 are be VBP cord-347946-i6kx3n6m 379 3 approximately approximately RB cord-347946-i6kx3n6m 379 4 twice twice RB cord-347946-i6kx3n6m 379 5 as as RB cord-347946-i6kx3n6m 379 6 likely likely JJ cord-347946-i6kx3n6m 379 7 as as IN cord-347946-i6kx3n6m 379 8 males male NNS cord-347946-i6kx3n6m 379 9 to to TO cord-347946-i6kx3n6m 379 10 suffer suffer VB cord-347946-i6kx3n6m 379 11 from from IN cord-347946-i6kx3n6m 379 12 MDD MDD NNP cord-347946-i6kx3n6m 379 13 ( ( -LRB- cord-347946-i6kx3n6m 379 14 Seedat Seedat NNP cord-347946-i6kx3n6m 379 15 et et FW cord-347946-i6kx3n6m 379 16 al al NNP cord-347946-i6kx3n6m 379 17 , , , cord-347946-i6kx3n6m 379 18 2009 2009 CD cord-347946-i6kx3n6m 379 19 ) ) -RRB- cord-347946-i6kx3n6m 379 20 , , , cord-347946-i6kx3n6m 379 21 with with IN cord-347946-i6kx3n6m 379 22 this this DT cord-347946-i6kx3n6m 379 23 imbalance imbalance NN cord-347946-i6kx3n6m 379 24 being be VBG cord-347946-i6kx3n6m 379 25 most most RBS cord-347946-i6kx3n6m 379 26 pronounced pronounce VBN cord-347946-i6kx3n6m 379 27 during during IN cord-347946-i6kx3n6m 379 28 the the DT cord-347946-i6kx3n6m 379 29 reproductive reproductive JJ cord-347946-i6kx3n6m 379 30 years year NNS cord-347946-i6kx3n6m 379 31 , , , cord-347946-i6kx3n6m 379 32 exactly exactly RB cord-347946-i6kx3n6m 379 33 when when WRB cord-347946-i6kx3n6m 379 34 the the DT cord-347946-i6kx3n6m 379 35 manifold manifold JJ cord-347946-i6kx3n6m 379 36 negative negative JJ cord-347946-i6kx3n6m 379 37 social social JJ cord-347946-i6kx3n6m 379 38 and and CC cord-347946-i6kx3n6m 379 39 biological biological JJ cord-347946-i6kx3n6m 379 40 effects effect NNS cord-347946-i6kx3n6m 379 41 of of IN cord-347946-i6kx3n6m 379 42 depression depression NN cord-347946-i6kx3n6m 379 43 would would MD cord-347946-i6kx3n6m 379 44 be be VB cord-347946-i6kx3n6m 379 45 expected expect VBN cord-347946-i6kx3n6m 379 46 to to TO cord-347946-i6kx3n6m 379 47 impact impact VB cord-347946-i6kx3n6m 379 48 evolutionary evolutionary JJ cord-347946-i6kx3n6m 379 49 fitness fitness NN cord-347946-i6kx3n6m 379 50 most most RBS cord-347946-i6kx3n6m 379 51 adversely adversely RB cord-347946-i6kx3n6m 379 52 ( ( -LRB- cord-347946-i6kx3n6m 379 53 Fiske Fiske NNP cord-347946-i6kx3n6m 379 54 et et NNP cord-347946-i6kx3n6m 379 55 al al NNP cord-347946-i6kx3n6m 379 56 , , , cord-347946-i6kx3n6m 379 57 2009 2009 CD cord-347946-i6kx3n6m 379 58 ) ) -RRB- cord-347946-i6kx3n6m 379 59 . . . cord-347946-i6kx3n6m 380 1 While while IN cord-347946-i6kx3n6m 380 2 many many JJ cord-347946-i6kx3n6m 380 3 answers answer NNS cord-347946-i6kx3n6m 380 4 for for IN cord-347946-i6kx3n6m 380 5 the the DT cord-347946-i6kx3n6m 380 6 female female JJ cord-347946-i6kx3n6m 380 7 preponderance preponderance NN cord-347946-i6kx3n6m 380 8 of of IN cord-347946-i6kx3n6m 380 9 depression depression NN cord-347946-i6kx3n6m 380 10 have have VBP cord-347946-i6kx3n6m 380 11 been be VBN cord-347946-i6kx3n6m 380 12 proposed propose VBN cord-347946-i6kx3n6m 380 13 over over IN cord-347946-i6kx3n6m 380 14 the the DT cord-347946-i6kx3n6m 380 15 years year NNS cord-347946-i6kx3n6m 380 16 ( ( -LRB- cord-347946-i6kx3n6m 380 17 eg eg RB cord-347946-i6kx3n6m 380 18 , , , cord-347946-i6kx3n6m 380 19 females female NNS cord-347946-i6kx3n6m 380 20 are be VBP cord-347946-i6kx3n6m 380 21 more more RBR cord-347946-i6kx3n6m 380 22 sensitive sensitive JJ cord-347946-i6kx3n6m 380 23 than than IN cord-347946-i6kx3n6m 380 24 males male NNS cord-347946-i6kx3n6m 380 25 to to IN cord-347946-i6kx3n6m 380 26 the the DT cord-347946-i6kx3n6m 380 27 social social JJ cord-347946-i6kx3n6m 380 28 environment environment NN cord-347946-i6kx3n6m 380 29 ) ) -RRB- cord-347946-i6kx3n6m 380 30 , , , cord-347946-i6kx3n6m 380 31 none none NN cord-347946-i6kx3n6m 380 32 have have VBP cord-347946-i6kx3n6m 380 33 successfully successfully RB cord-347946-i6kx3n6m 380 34 identified identify VBN cord-347946-i6kx3n6m 380 35 an an DT cord-347946-i6kx3n6m 380 36 adaptive adaptive JJ cord-347946-i6kx3n6m 380 37 advantage advantage NN cord-347946-i6kx3n6m 380 38 that that WDT cord-347946-i6kx3n6m 380 39 would would MD cord-347946-i6kx3n6m 380 40 outweigh outweigh VB cord-347946-i6kx3n6m 380 41 the the DT cord-347946-i6kx3n6m 380 42 costs cost NNS cord-347946-i6kx3n6m 380 43 of of IN cord-347946-i6kx3n6m 380 44 female female JJ cord-347946-i6kx3n6m 380 45 depression depression NN cord-347946-i6kx3n6m 380 46 to to IN cord-347946-i6kx3n6m 380 47 survival survival NN cord-347946-i6kx3n6m 380 48 and and CC cord-347946-i6kx3n6m 380 49 reproduction reproduction NN cord-347946-i6kx3n6m 380 50 . . . cord-347946-i6kx3n6m 381 1 In in IN cord-347946-i6kx3n6m 381 2 contrast contrast NN cord-347946-i6kx3n6m 381 3 , , , cord-347946-i6kx3n6m 381 4 PATHOS pathos NN cord-347946-i6kx3n6m 381 5 - - HYPH cord-347946-i6kx3n6m 381 6 D D NNP cord-347946-i6kx3n6m 381 7 suggests suggest VBZ cord-347946-i6kx3n6m 381 8 a a DT cord-347946-i6kx3n6m 381 9 testable testable JJ cord-347946-i6kx3n6m 381 10 explanation explanation NN cord-347946-i6kx3n6m 381 11 for for IN cord-347946-i6kx3n6m 381 12 why why WRB cord-347946-i6kx3n6m 381 13 depression depression NN cord-347946-i6kx3n6m 381 14 is be VBZ cord-347946-i6kx3n6m 381 15 so so RB cord-347946-i6kx3n6m 381 16 common common JJ cord-347946-i6kx3n6m 381 17 in in IN cord-347946-i6kx3n6m 381 18 females female NNS cord-347946-i6kx3n6m 381 19 of of IN cord-347946-i6kx3n6m 381 20 reproductive reproductive JJ cord-347946-i6kx3n6m 381 21 age age NN cord-347946-i6kx3n6m 381 22 . . . cord-347946-i6kx3n6m 382 1 Females female NNS cord-347946-i6kx3n6m 382 2 are be VBP cord-347946-i6kx3n6m 382 3 more more RBR cord-347946-i6kx3n6m 382 4 likely likely JJ cord-347946-i6kx3n6m 382 5 to to TO cord-347946-i6kx3n6m 382 6 develop develop VB cord-347946-i6kx3n6m 382 7 depression depression NN cord-347946-i6kx3n6m 382 8 during during IN cord-347946-i6kx3n6m 382 9 the the DT cord-347946-i6kx3n6m 382 10 reproductive reproductive JJ cord-347946-i6kx3n6m 382 11 years year NNS cord-347946-i6kx3n6m 382 12 because because IN cord-347946-i6kx3n6m 382 13 across across IN cord-347946-i6kx3n6m 382 14 evolutionary evolutionary JJ cord-347946-i6kx3n6m 382 15 time time NN cord-347946-i6kx3n6m 382 16 depressive depressive JJ cord-347946-i6kx3n6m 382 17 symptoms symptom NNS cord-347946-i6kx3n6m 382 18 - - : cord-347946-i6kx3n6m 382 19 having have VBG cord-347946-i6kx3n6m 382 20 evolved evolve VBN cord-347946-i6kx3n6m 382 21 out out IN cord-347946-i6kx3n6m 382 22 of of IN cord-347946-i6kx3n6m 382 23 sickness sickness NN cord-347946-i6kx3n6m 382 24 - - HYPH cord-347946-i6kx3n6m 382 25 promoted promote VBN cord-347946-i6kx3n6m 382 26 behaviors behavior NNS cord-347946-i6kx3n6m 382 27 that that WDT cord-347946-i6kx3n6m 382 28 decreased decrease VBD cord-347946-i6kx3n6m 382 29 the the DT cord-347946-i6kx3n6m 382 30 risk risk NN cord-347946-i6kx3n6m 382 31 of of IN cord-347946-i6kx3n6m 382 32 pathogen pathogen NN cord-347946-i6kx3n6m 382 33 exposure exposure NN cord-347946-i6kx3n6m 382 34 and and CC cord-347946-i6kx3n6m 382 35 provided provide VBN cord-347946-i6kx3n6m 382 36 increased increased JJ cord-347946-i6kx3n6m 382 37 protection protection NN cord-347946-i6kx3n6m 382 38 from from IN cord-347946-i6kx3n6m 382 39 pathogens pathogen NNS cord-347946-i6kx3n6m 382 40 for for IN cord-347946-i6kx3n6m 382 41 any any DT cord-347946-i6kx3n6m 382 42 given give VBN cord-347946-i6kx3n6m 382 43 level level NN cord-347946-i6kx3n6m 382 44 of of IN cord-347946-i6kx3n6m 382 45 inflammatory inflammatory JJ cord-347946-i6kx3n6m 382 46 activation activation NN cord-347946-i6kx3n6m 382 47 once once IN cord-347946-i6kx3n6m 382 48 an an DT cord-347946-i6kx3n6m 382 49 infection infection NN cord-347946-i6kx3n6m 382 50 had have VBD cord-347946-i6kx3n6m 382 51 occurred occur VBN cord-347946-i6kx3n6m 382 52 ( ( -LRB- cord-347946-i6kx3n6m 382 53 eg eg UH cord-347946-i6kx3n6m 382 54 , , , cord-347946-i6kx3n6m 382 55 by by IN cord-347946-i6kx3n6m 382 56 increasing increase VBG cord-347946-i6kx3n6m 382 57 energy energy NN cord-347946-i6kx3n6m 382 58 available available JJ cord-347946-i6kx3n6m 382 59 to to IN cord-347946-i6kx3n6m 382 60 immune immune JJ cord-347946-i6kx3n6m 382 61 processes process NNS cord-347946-i6kx3n6m 382 62 by by IN cord-347946-i6kx3n6m 382 63 inducing induce VBG cord-347946-i6kx3n6m 382 64 conservation conservation NN cord-347946-i6kx3n6m 382 65 - - HYPH cord-347946-i6kx3n6m 382 66 withdrawal withdrawal NN cord-347946-i6kx3n6m 382 67 behavior behavior NN cord-347946-i6kx3n6m 382 68 , , , cord-347946-i6kx3n6m 382 69 maintaining maintain VBG cord-347946-i6kx3n6m 382 70 elevated elevated JJ cord-347946-i6kx3n6m 382 71 body body NN cord-347946-i6kx3n6m 382 72 temperature temperature NN cord-347946-i6kx3n6m 382 73 , , , cord-347946-i6kx3n6m 382 74 and and CC cord-347946-i6kx3n6m 382 75 so so RB cord-347946-i6kx3n6m 382 76 on on RB cord-347946-i6kx3n6m 382 77 ) ) -RRB- cord-347946-i6kx3n6m 382 78 . . . cord-347946-i6kx3n6m 383 1 Said say VBD cord-347946-i6kx3n6m 383 2 differently differently RB cord-347946-i6kx3n6m 383 3 , , , cord-347946-i6kx3n6m 383 4 by by IN cord-347946-i6kx3n6m 383 5 inducing induce VBG cord-347946-i6kx3n6m 383 6 social social JJ cord-347946-i6kx3n6m 383 7 and and CC cord-347946-i6kx3n6m 383 8 biological biological JJ cord-347946-i6kx3n6m 383 9 behaviors behavior NNS cord-347946-i6kx3n6m 383 10 that that WDT cord-347946-i6kx3n6m 383 11 promoted promote VBD cord-347946-i6kx3n6m 383 12 host host NN cord-347946-i6kx3n6m 383 13 defense defense NN cord-347946-i6kx3n6m 383 14 against against IN cord-347946-i6kx3n6m 383 15 pathogens pathogen NNS cord-347946-i6kx3n6m 383 16 , , , cord-347946-i6kx3n6m 383 17 depressive depressive JJ cord-347946-i6kx3n6m 383 18 symptoms symptom NNS cord-347946-i6kx3n6m 383 19 allowed allow VBD cord-347946-i6kx3n6m 383 20 females female NNS cord-347946-i6kx3n6m 383 21 of of IN cord-347946-i6kx3n6m 383 22 reproductive reproductive JJ cord-347946-i6kx3n6m 383 23 age age NN cord-347946-i6kx3n6m 383 24 to to TO cord-347946-i6kx3n6m 383 25 ' ' '' cord-347946-i6kx3n6m 383 26 get get VB cord-347946-i6kx3n6m 383 27 by by IN cord-347946-i6kx3n6m 383 28 ' ' '' cord-347946-i6kx3n6m 383 29 with with IN cord-347946-i6kx3n6m 383 30 less less JJR cord-347946-i6kx3n6m 383 31 inflammation inflammation NN cord-347946-i6kx3n6m 383 32 . . . cord-347946-i6kx3n6m 384 1 The the DT cord-347946-i6kx3n6m 384 2 unique unique JJ cord-347946-i6kx3n6m 384 3 importance importance NN cord-347946-i6kx3n6m 384 4 of of IN cord-347946-i6kx3n6m 384 5 this this DT cord-347946-i6kx3n6m 384 6 for for IN cord-347946-i6kx3n6m 384 7 reproductive reproductive JJ cord-347946-i6kx3n6m 384 8 success success NN cord-347946-i6kx3n6m 384 9 in in IN cord-347946-i6kx3n6m 384 10 females female NNS cord-347946-i6kx3n6m 384 11 is be VBZ cord-347946-i6kx3n6m 384 12 highlighted highlight VBN cord-347946-i6kx3n6m 384 13 by by IN cord-347946-i6kx3n6m 384 14 the the DT cord-347946-i6kx3n6m 384 15 fact fact NN cord-347946-i6kx3n6m 384 16 that that IN cord-347946-i6kx3n6m 384 17 inflammation inflammation NN cord-347946-i6kx3n6m 384 18 reduces reduce VBZ cord-347946-i6kx3n6m 384 19 fertility fertility NN cord-347946-i6kx3n6m 384 20 , , , cord-347946-i6kx3n6m 384 21 impairs impair VBZ cord-347946-i6kx3n6m 384 22 lactation lactation NN cord-347946-i6kx3n6m 384 23 and and CC cord-347946-i6kx3n6m 384 24 directs direct VBZ cord-347946-i6kx3n6m 384 25 metabolic metabolic JJ cord-347946-i6kx3n6m 384 26 resources resource NNS cord-347946-i6kx3n6m 384 27 away away RB cord-347946-i6kx3n6m 384 28 from from IN cord-347946-i6kx3n6m 384 29 the the DT cord-347946-i6kx3n6m 384 30 multiple multiple JJ cord-347946-i6kx3n6m 384 31 energetically energetically RB cord-347946-i6kx3n6m 384 32 - - HYPH cord-347946-i6kx3n6m 384 33 costly costly JJ cord-347946-i6kx3n6m 384 34 aspects aspect NNS cord-347946-i6kx3n6m 384 35 of of IN cord-347946-i6kx3n6m 384 36 female female JJ cord-347946-i6kx3n6m 384 37 biology biology NN cord-347946-i6kx3n6m 384 38 that that WDT cord-347946-i6kx3n6m 384 39 were be VBD cord-347946-i6kx3n6m 384 40 required require VBN cord-347946-i6kx3n6m 384 41 for for IN cord-347946-i6kx3n6m 384 42 successful successful JJ cord-347946-i6kx3n6m 384 43 reproduction reproduction NN cord-347946-i6kx3n6m 384 44 in in IN cord-347946-i6kx3n6m 384 45 ancestral ancestral JJ cord-347946-i6kx3n6m 384 46 environments environment NNS cord-347946-i6kx3n6m 385 1 ( ( -LRB- cord-347946-i6kx3n6m 385 2 Van Van NNP cord-347946-i6kx3n6m 385 3 Bodegom Bodegom NNP cord-347946-i6kx3n6m 385 4 et et NNP cord-347946-i6kx3n6m 385 5 al al NNP cord-347946-i6kx3n6m 385 6 , , , cord-347946-i6kx3n6m 385 7 2007 2007 CD cord-347946-i6kx3n6m 385 8 ; ; : cord-347946-i6kx3n6m 385 9 Schaller Schaller NNP cord-347946-i6kx3n6m 385 10 , , , cord-347946-i6kx3n6m 385 11 2011 2011 CD cord-347946-i6kx3n6m 385 12 ; ; : cord-347946-i6kx3n6m 385 13 Kobayashi Kobayashi NNP cord-347946-i6kx3n6m 385 14 et et NNP cord-347946-i6kx3n6m 385 15 al al NNP cord-347946-i6kx3n6m 385 16 , , , cord-347946-i6kx3n6m 385 17 2013 2013 CD cord-347946-i6kx3n6m 385 18 ) ) -RRB- cord-347946-i6kx3n6m 385 19 . . . cord-347946-i6kx3n6m 386 1 Interestingly interestingly RB cord-347946-i6kx3n6m 386 2 MDD MDD NNP cord-347946-i6kx3n6m 386 3 has have VBZ cord-347946-i6kx3n6m 386 4 also also RB cord-347946-i6kx3n6m 386 5 been be VBN cord-347946-i6kx3n6m 386 6 associated associate VBN cord-347946-i6kx3n6m 386 7 with with IN cord-347946-i6kx3n6m 386 8 reduced reduce VBN cord-347946-i6kx3n6m 386 9 fertility fertility NN cord-347946-i6kx3n6m 386 10 ( ( -LRB- cord-347946-i6kx3n6m 386 11 Williams Williams NNP cord-347946-i6kx3n6m 386 12 et et NNP cord-347946-i6kx3n6m 386 13 al al NNP cord-347946-i6kx3n6m 386 14 , , , cord-347946-i6kx3n6m 386 15 2007 2007 CD cord-347946-i6kx3n6m 386 16 ; ; : cord-347946-i6kx3n6m 386 17 Nillni Nillni NNP cord-347946-i6kx3n6m 386 18 et et NNP cord-347946-i6kx3n6m 386 19 al al NNP cord-347946-i6kx3n6m 386 20 , , , cord-347946-i6kx3n6m 386 21 2016 2016 CD cord-347946-i6kx3n6m 386 22 ) ) -RRB- cord-347946-i6kx3n6m 386 23 . . . cord-347946-i6kx3n6m 387 1 PATHOS pathos NN cord-347946-i6kx3n6m 387 2 - - HYPH cord-347946-i6kx3n6m 387 3 D d NN cord-347946-i6kx3n6m 387 4 theory theory NN cord-347946-i6kx3n6m 387 5 predicts predict VBZ cord-347946-i6kx3n6m 387 6 that that IN cord-347946-i6kx3n6m 387 7 this this DT cord-347946-i6kx3n6m 387 8 association association NN cord-347946-i6kx3n6m 387 9 should should MD cord-347946-i6kx3n6m 387 10 less less RBR cord-347946-i6kx3n6m 387 11 prominent prominent JJ cord-347946-i6kx3n6m 387 12 in in IN cord-347946-i6kx3n6m 387 13 females female NNS cord-347946-i6kx3n6m 387 14 who who WP cord-347946-i6kx3n6m 387 15 have have VBP cord-347946-i6kx3n6m 387 16 effectively effectively RB cord-347946-i6kx3n6m 387 17 ' ' `` cord-347946-i6kx3n6m 387 18 replaced replace VBN cord-347946-i6kx3n6m 387 19 ' ' '' cord-347946-i6kx3n6m 387 20 inflammation inflammation NN cord-347946-i6kx3n6m 387 21 with with IN cord-347946-i6kx3n6m 387 22 depression depression NN cord-347946-i6kx3n6m 387 23 - - HYPH cord-347946-i6kx3n6m 387 24 based base VBN cord-347946-i6kx3n6m 387 25 behavioral behavioral JJ cord-347946-i6kx3n6m 387 26 pathogen pathogen NN cord-347946-i6kx3n6m 387 27 avoidance avoidance NN cord-347946-i6kx3n6m 387 28 in in IN cord-347946-i6kx3n6m 387 29 the the DT cord-347946-i6kx3n6m 387 30 absence absence NN cord-347946-i6kx3n6m 387 31 of of IN cord-347946-i6kx3n6m 387 32 elevated elevated JJ cord-347946-i6kx3n6m 387 33 levels level NNS cord-347946-i6kx3n6m 387 34 of of IN cord-347946-i6kx3n6m 387 35 inflammatory inflammatory JJ cord-347946-i6kx3n6m 387 36 biomarkers biomarker NNS cord-347946-i6kx3n6m 387 37 . . . cord-347946-i6kx3n6m 388 1 Although although IN cord-347946-i6kx3n6m 388 2 most most JJS cord-347946-i6kx3n6m 388 3 implications implication NNS cord-347946-i6kx3n6m 388 4 of of IN cord-347946-i6kx3n6m 388 5 this this DT cord-347946-i6kx3n6m 388 6 idea idea NN cord-347946-i6kx3n6m 388 7 remain remain VBP cord-347946-i6kx3n6m 388 8 to to TO cord-347946-i6kx3n6m 388 9 be be VB cord-347946-i6kx3n6m 388 10 tested test VBN cord-347946-i6kx3n6m 388 11 , , , cord-347946-i6kx3n6m 388 12 some some DT cord-347946-i6kx3n6m 388 13 data datum NNS cord-347946-i6kx3n6m 388 14 support support VBP cord-347946-i6kx3n6m 388 15 the the DT cord-347946-i6kx3n6m 388 16 first first JJ cord-347946-i6kx3n6m 388 17 prediction prediction NN cord-347946-i6kx3n6m 388 18 of of IN cord-347946-i6kx3n6m 388 19 this this DT cord-347946-i6kx3n6m 388 20 hypothesis hypothesis NN cord-347946-i6kx3n6m 388 21 , , , cord-347946-i6kx3n6m 388 22 which which WDT cord-347946-i6kx3n6m 388 23 is be VBZ cord-347946-i6kx3n6m 388 24 that that IN cord-347946-i6kx3n6m 388 25 females female NNS cord-347946-i6kx3n6m 388 26 should should MD cord-347946-i6kx3n6m 388 27 develop develop VB cord-347946-i6kx3n6m 388 28 increased increase VBN cord-347946-i6kx3n6m 388 29 levels level NNS cord-347946-i6kx3n6m 388 30 of of IN cord-347946-i6kx3n6m 388 31 depression depression NN cord-347946-i6kx3n6m 388 32 for for IN cord-347946-i6kx3n6m 388 33 any any DT cord-347946-i6kx3n6m 388 34 given give VBN cord-347946-i6kx3n6m 388 35 amount amount NN cord-347946-i6kx3n6m 388 36 of of IN cord-347946-i6kx3n6m 388 37 inflammatory inflammatory JJ cord-347946-i6kx3n6m 388 38 exposure exposure NN cord-347946-i6kx3n6m 388 39 . . . cord-347946-i6kx3n6m 389 1 Indeed indeed RB cord-347946-i6kx3n6m 389 2 , , , cord-347946-i6kx3n6m 389 3 when when WRB cord-347946-i6kx3n6m 389 4 compared compare VBN cord-347946-i6kx3n6m 389 5 with with IN cord-347946-i6kx3n6m 389 6 men man NNS cord-347946-i6kx3n6m 389 7 , , , cord-347946-i6kx3n6m 389 8 females female NNS cord-347946-i6kx3n6m 389 9 respond respond VBP cord-347946-i6kx3n6m 389 10 to to IN cord-347946-i6kx3n6m 389 11 an an DT cord-347946-i6kx3n6m 389 12 injection injection NN cord-347946-i6kx3n6m 389 13 of of IN cord-347946-i6kx3n6m 389 14 lipopolysaccharide lipopolysaccharide NN cord-347946-i6kx3n6m 389 15 ( ( -LRB- cord-347946-i6kx3n6m 389 16 LPS LPS NNP cord-347946-i6kx3n6m 389 17 ) ) -RRB- cord-347946-i6kx3n6m 389 18 with with IN cord-347946-i6kx3n6m 389 19 an an DT cord-347946-i6kx3n6m 389 20 increase increase NN cord-347946-i6kx3n6m 389 21 in in IN cord-347946-i6kx3n6m 389 22 depression depression NN cord-347946-i6kx3n6m 389 23 and and CC cord-347946-i6kx3n6m 389 24 feelings feeling NNS cord-347946-i6kx3n6m 389 25 of of IN cord-347946-i6kx3n6m 389 26 social social JJ cord-347946-i6kx3n6m 389 27 isolation isolation NN cord-347946-i6kx3n6m 389 28 , , , cord-347946-i6kx3n6m 389 29 both both DT cord-347946-i6kx3n6m 389 30 of of IN cord-347946-i6kx3n6m 389 31 which which WDT cord-347946-i6kx3n6m 389 32 are be VBP cord-347946-i6kx3n6m 389 33 correlated correlate VBN cord-347946-i6kx3n6m 389 34 with with IN cord-347946-i6kx3n6m 389 35 amount amount NN cord-347946-i6kx3n6m 389 36 of of IN cord-347946-i6kx3n6m 389 37 cytokine cytokine NN cord-347946-i6kx3n6m 389 38 response response NN cord-347946-i6kx3n6m 389 39 to to IN cord-347946-i6kx3n6m 389 40 the the DT cord-347946-i6kx3n6m 389 41 LPS lp NNS cord-347946-i6kx3n6m 389 42 in in IN cord-347946-i6kx3n6m 389 43 females female NNS cord-347946-i6kx3n6m 389 44 , , , cord-347946-i6kx3n6m 389 45 but but CC cord-347946-i6kx3n6m 389 46 not not RB cord-347946-i6kx3n6m 389 47 males male NNS cord-347946-i6kx3n6m 389 48 ( ( -LRB- cord-347946-i6kx3n6m 389 49 Moieni Moieni NNP cord-347946-i6kx3n6m 389 50 et et NNP cord-347946-i6kx3n6m 389 51 al al NNP cord-347946-i6kx3n6m 389 52 , , , cord-347946-i6kx3n6m 389 53 2015b 2015b CD cord-347946-i6kx3n6m 389 54 ) ) -RRB- cord-347946-i6kx3n6m 389 55 . . . cord-347946-i6kx3n6m 390 1 Similarly similarly RB cord-347946-i6kx3n6m 390 2 , , , cord-347946-i6kx3n6m 390 3 females female NNS cord-347946-i6kx3n6m 390 4 are be VBP cord-347946-i6kx3n6m 390 5 more more RBR cord-347946-i6kx3n6m 390 6 likely likely JJ cord-347946-i6kx3n6m 390 7 than than IN cord-347946-i6kx3n6m 390 8 males male NNS cord-347946-i6kx3n6m 390 9 to to TO cord-347946-i6kx3n6m 390 10 develop develop VB cord-347946-i6kx3n6m 390 11 depression depression NN cord-347946-i6kx3n6m 390 12 in in IN cord-347946-i6kx3n6m 390 13 response response NN cord-347946-i6kx3n6m 390 14 to to TO cord-347946-i6kx3n6m 390 15 chronic chronic VB cord-347946-i6kx3n6m 390 16 inflammatory inflammatory JJ cord-347946-i6kx3n6m 390 17 stimulation stimulation NN cord-347946-i6kx3n6m 390 18 resulting result VBG cord-347946-i6kx3n6m 390 19 from from IN cord-347946-i6kx3n6m 390 20 treatment treatment NN cord-347946-i6kx3n6m 390 21 with with IN cord-347946-i6kx3n6m 390 22 the the DT cord-347946-i6kx3n6m 390 23 cytokine cytokine NN cord-347946-i6kx3n6m 390 24 IFN IFN NNP cord-347946-i6kx3n6m 390 25 - - HYPH cord-347946-i6kx3n6m 390 26 α α NNP cord-347946-i6kx3n6m 390 27 ( ( -LRB- cord-347946-i6kx3n6m 390 28 Udina Udina NNP cord-347946-i6kx3n6m 390 29 et et NNP cord-347946-i6kx3n6m 390 30 al al NNP cord-347946-i6kx3n6m 390 31 , , , cord-347946-i6kx3n6m 390 32 2012 2012 CD cord-347946-i6kx3n6m 390 33 ) ) -RRB- cord-347946-i6kx3n6m 390 34 . . . cord-347946-i6kx3n6m 391 1 Finally finally RB cord-347946-i6kx3n6m 391 2 , , , cord-347946-i6kx3n6m 391 3 given give VBN cord-347946-i6kx3n6m 391 4 the the DT cord-347946-i6kx3n6m 391 5 pre pre JJ cord-347946-i6kx3n6m 391 6 - - JJ cord-347946-i6kx3n6m 391 7 eminent eminent JJ cord-347946-i6kx3n6m 391 8 role role NN cord-347946-i6kx3n6m 391 9 of of IN cord-347946-i6kx3n6m 391 10 psychosocial psychosocial JJ cord-347946-i6kx3n6m 391 11 stress stress NN cord-347946-i6kx3n6m 391 12 as as IN cord-347946-i6kx3n6m 391 13 an an DT cord-347946-i6kx3n6m 391 14 environmental environmental JJ cord-347946-i6kx3n6m 391 15 risk risk NN cord-347946-i6kx3n6m 391 16 factor factor NN cord-347946-i6kx3n6m 391 17 for for IN cord-347946-i6kx3n6m 391 18 MDD MDD NNP cord-347946-i6kx3n6m 391 19 , , , cord-347946-i6kx3n6m 391 20 as as RB cord-347946-i6kx3n6m 391 21 well well RB cord-347946-i6kx3n6m 391 22 as as IN cord-347946-i6kx3n6m 391 23 evidence evidence NN cord-347946-i6kx3n6m 391 24 that that IN cord-347946-i6kx3n6m 391 25 hyperthermia hyperthermia NN cord-347946-i6kx3n6m 391 26 enhances enhance VBZ cord-347946-i6kx3n6m 391 27 host host NN cord-347946-i6kx3n6m 391 28 defense defense NN cord-347946-i6kx3n6m 391 29 , , , cord-347946-i6kx3n6m 391 30 it -PRON- PRP cord-347946-i6kx3n6m 391 31 is be VBZ cord-347946-i6kx3n6m 391 32 intriguing intriguing JJ cord-347946-i6kx3n6m 391 33 that that IN cord-347946-i6kx3n6m 391 34 reproductive reproductive JJ cord-347946-i6kx3n6m 391 35 aged age VBN cord-347946-i6kx3n6m 391 36 females female NNS cord-347946-i6kx3n6m 391 37 appear appear VBP cord-347946-i6kx3n6m 391 38 to to TO cord-347946-i6kx3n6m 391 39 be be VB cord-347946-i6kx3n6m 391 40 most most RBS cord-347946-i6kx3n6m 391 41 vulnerable vulnerable JJ cord-347946-i6kx3n6m 391 42 to to IN cord-347946-i6kx3n6m 391 43 developing develop VBG cord-347946-i6kx3n6m 391 44 psychogenic psychogenic JJ cord-347946-i6kx3n6m 391 45 fever fever NN cord-347946-i6kx3n6m 391 46 ( ( -LRB- cord-347946-i6kx3n6m 391 47 Kaneda Kaneda NNP cord-347946-i6kx3n6m 391 48 et et NNP cord-347946-i6kx3n6m 391 49 al al NNP cord-347946-i6kx3n6m 391 50 , , , cord-347946-i6kx3n6m 391 51 2009 2009 CD cord-347946-i6kx3n6m 391 52 ) ) -RRB- cord-347946-i6kx3n6m 391 53 . . . cord-347946-i6kx3n6m 392 1 However however RB cord-347946-i6kx3n6m 392 2 , , , cord-347946-i6kx3n6m 392 3 these these DT cord-347946-i6kx3n6m 392 4 findings finding NNS cord-347946-i6kx3n6m 392 5 need need VBP cord-347946-i6kx3n6m 392 6 to to TO cord-347946-i6kx3n6m 392 7 be be VB cord-347946-i6kx3n6m 392 8 balanced balance VBN cord-347946-i6kx3n6m 392 9 against against IN cord-347946-i6kx3n6m 392 10 results result NNS cord-347946-i6kx3n6m 392 11 from from IN cord-347946-i6kx3n6m 392 12 a a DT cord-347946-i6kx3n6m 392 13 small small JJ cord-347946-i6kx3n6m 392 14 recent recent JJ cord-347946-i6kx3n6m 392 15 study study NN cord-347946-i6kx3n6m 392 16 indicating indicate VBG cord-347946-i6kx3n6m 392 17 that that IN cord-347946-i6kx3n6m 392 18 females female NNS cord-347946-i6kx3n6m 392 19 mounted mount VBD cord-347946-i6kx3n6m 392 20 an an DT cord-347946-i6kx3n6m 392 21 enhanced enhanced JJ cord-347946-i6kx3n6m 392 22 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 392 23 cytokine cytokine NN cord-347946-i6kx3n6m 392 24 response response NN cord-347946-i6kx3n6m 392 25 to to IN cord-347946-i6kx3n6m 392 26 low low JJ cord-347946-i6kx3n6m 392 27 - - HYPH cord-347946-i6kx3n6m 392 28 dose dose NN cord-347946-i6kx3n6m 392 29 endotoxin endotoxin NN cord-347946-i6kx3n6m 392 30 when when WRB cord-347946-i6kx3n6m 392 31 compared compare VBN cord-347946-i6kx3n6m 392 32 with with IN cord-347946-i6kx3n6m 392 33 men man NNS cord-347946-i6kx3n6m 392 34 , , , cord-347946-i6kx3n6m 392 35 while while IN cord-347946-i6kx3n6m 392 36 showing show VBG cord-347946-i6kx3n6m 392 37 no no DT cord-347946-i6kx3n6m 392 38 difference difference NN cord-347946-i6kx3n6m 392 39 in in IN cord-347946-i6kx3n6m 392 40 inflammation inflammation NN cord-347946-i6kx3n6m 392 41 - - HYPH cord-347946-i6kx3n6m 392 42 induced induce VBN cord-347946-i6kx3n6m 392 43 mood mood NN cord-347946-i6kx3n6m 392 44 or or CC cord-347946-i6kx3n6m 392 45 anxiety anxiety NN cord-347946-i6kx3n6m 392 46 symptoms symptom NNS cord-347946-i6kx3n6m 392 47 - - : cord-347946-i6kx3n6m 392 48 a a DT cord-347946-i6kx3n6m 392 49 pattern pattern NN cord-347946-i6kx3n6m 392 50 of of IN cord-347946-i6kx3n6m 392 51 findings finding NNS cord-347946-i6kx3n6m 392 52 opposite opposite JJ cord-347946-i6kx3n6m 392 53 to to IN cord-347946-i6kx3n6m 392 54 this this DT cord-347946-i6kx3n6m 392 55 PATHOS PATHOS NNP cord-347946-i6kx3n6m 392 56 - - HYPH cord-347946-i6kx3n6m 392 57 D d JJ cord-347946-i6kx3n6m 392 58 prediction prediction NN cord-347946-i6kx3n6m 392 59 ( ( -LRB- cord-347946-i6kx3n6m 392 60 Engler Engler NNP cord-347946-i6kx3n6m 392 61 et et NNP cord-347946-i6kx3n6m 392 62 al al NNP cord-347946-i6kx3n6m 392 63 , , , cord-347946-i6kx3n6m 392 64 2016 2016 CD cord-347946-i6kx3n6m 392 65 ) ) -RRB- cord-347946-i6kx3n6m 392 66 . . . cord-347946-i6kx3n6m 393 1 If if IN cord-347946-i6kx3n6m 393 2 confirmed confirm VBN cord-347946-i6kx3n6m 393 3 in in IN cord-347946-i6kx3n6m 393 4 larger large JJR cord-347946-i6kx3n6m 393 5 studies study NNS cord-347946-i6kx3n6m 393 6 , , , cord-347946-i6kx3n6m 393 7 these these DT cord-347946-i6kx3n6m 393 8 findings finding NNS cord-347946-i6kx3n6m 393 9 might may MD cord-347946-i6kx3n6m 393 10 support support VB cord-347946-i6kx3n6m 393 11 an an DT cord-347946-i6kx3n6m 393 12 alternative alternative JJ cord-347946-i6kx3n6m 393 13 immune immune NN cord-347946-i6kx3n6m 393 14 - - HYPH cord-347946-i6kx3n6m 393 15 based base VBN cord-347946-i6kx3n6m 393 16 mechanism mechanism NN cord-347946-i6kx3n6m 393 17 for for IN cord-347946-i6kx3n6m 393 18 the the DT cord-347946-i6kx3n6m 393 19 female female JJ cord-347946-i6kx3n6m 393 20 / / SYM cord-347946-i6kx3n6m 393 21 male male JJ cord-347946-i6kx3n6m 393 22 preponderance preponderance NN cord-347946-i6kx3n6m 393 23 of of IN cord-347946-i6kx3n6m 393 24 depression depression NN cord-347946-i6kx3n6m 393 25 and and CC cord-347946-i6kx3n6m 393 26 anxiety anxiety NN cord-347946-i6kx3n6m 393 27 , , , cord-347946-i6kx3n6m 393 28 specifically specifically RB cord-347946-i6kx3n6m 393 29 that that IN cord-347946-i6kx3n6m 393 30 females female NNS cord-347946-i6kx3n6m 393 31 respond respond VBP cord-347946-i6kx3n6m 393 32 to to IN cord-347946-i6kx3n6m 393 33 immune immune JJ cord-347946-i6kx3n6m 393 34 challenges challenge NNS cord-347946-i6kx3n6m 393 35 with with IN cord-347946-i6kx3n6m 393 36 greater great JJR cord-347946-i6kx3n6m 393 37 immune immune JJ cord-347946-i6kx3n6m 393 38 activation activation NN cord-347946-i6kx3n6m 393 39 which which WDT cord-347946-i6kx3n6m 393 40 subsequently subsequently RB cord-347946-i6kx3n6m 393 41 increases increase VBZ cord-347946-i6kx3n6m 393 42 the the DT cord-347946-i6kx3n6m 393 43 risk risk NN cord-347946-i6kx3n6m 393 44 for for IN cord-347946-i6kx3n6m 393 45 depression depression NN cord-347946-i6kx3n6m 393 46 / / SYM cord-347946-i6kx3n6m 393 47 anxiety anxiety NN cord-347946-i6kx3n6m 393 48 . . . cord-347946-i6kx3n6m 394 1 MDD MDD NNP cord-347946-i6kx3n6m 394 2 is be VBZ cord-347946-i6kx3n6m 394 3 most most RBS cord-347946-i6kx3n6m 394 4 commonly commonly RB cord-347946-i6kx3n6m 394 5 characterized characterize VBN cord-347946-i6kx3n6m 394 6 by by IN cord-347946-i6kx3n6m 394 7 impaired impaired JJ cord-347946-i6kx3n6m 394 8 sleep sleep NN cord-347946-i6kx3n6m 394 9 and and CC cord-347946-i6kx3n6m 394 10 reduced reduce VBN cord-347946-i6kx3n6m 394 11 appetite appetite NN cord-347946-i6kx3n6m 394 12 , , , cord-347946-i6kx3n6m 394 13 but but CC cord-347946-i6kx3n6m 394 14 a a DT cord-347946-i6kx3n6m 394 15 significant significant JJ cord-347946-i6kx3n6m 394 16 minority minority NN cord-347946-i6kx3n6m 394 17 of of IN cord-347946-i6kx3n6m 394 18 depressed depressed JJ cord-347946-i6kx3n6m 394 19 individuals individual NNS cord-347946-i6kx3n6m 394 20 manifest manifest VBP cord-347946-i6kx3n6m 394 21 hypersomnia hypersomnia NN cord-347946-i6kx3n6m 394 22 and and CC cord-347946-i6kx3n6m 394 23 hyperphagia hyperphagia NNP cord-347946-i6kx3n6m 394 24 instead instead RB cord-347946-i6kx3n6m 395 1 ( ( -LRB- cord-347946-i6kx3n6m 395 2 Thase Thase NNP cord-347946-i6kx3n6m 395 3 , , , cord-347946-i6kx3n6m 395 4 2009 2009 CD cord-347946-i6kx3n6m 395 5 ) ) -RRB- cord-347946-i6kx3n6m 395 6 . . . cord-347946-i6kx3n6m 396 1 These these DT cord-347946-i6kx3n6m 396 2 symptoms symptom NNS cord-347946-i6kx3n6m 396 3 are be VBP cord-347946-i6kx3n6m 396 4 most most RBS cord-347946-i6kx3n6m 396 5 frequent frequent JJ cord-347946-i6kx3n6m 396 6 in in IN cord-347946-i6kx3n6m 396 7 females female NNS cord-347946-i6kx3n6m 396 8 between between IN cord-347946-i6kx3n6m 396 9 adolescence adolescence NN cord-347946-i6kx3n6m 396 10 and and CC cord-347946-i6kx3n6m 396 11 middleage middleage NN cord-347946-i6kx3n6m 396 12 ( ( -LRB- cord-347946-i6kx3n6m 396 13 Carter Carter NNP cord-347946-i6kx3n6m 396 14 et et NNP cord-347946-i6kx3n6m 396 15 al al NNP cord-347946-i6kx3n6m 396 16 , , , cord-347946-i6kx3n6m 396 17 2000 2000 CD cord-347946-i6kx3n6m 396 18 ; ; : cord-347946-i6kx3n6m 396 19 Posternak Posternak NNP cord-347946-i6kx3n6m 396 20 and and CC cord-347946-i6kx3n6m 396 21 Zimmerman Zimmerman NNP cord-347946-i6kx3n6m 396 22 , , , cord-347946-i6kx3n6m 396 23 2001 2001 CD cord-347946-i6kx3n6m 396 24 ; ; : cord-347946-i6kx3n6m 396 25 Matza Matza NNP cord-347946-i6kx3n6m 396 26 et et NNP cord-347946-i6kx3n6m 396 27 al al NNP cord-347946-i6kx3n6m 396 28 , , , cord-347946-i6kx3n6m 396 29 2003 2003 CD cord-347946-i6kx3n6m 396 30 ; ; : cord-347946-i6kx3n6m 396 31 Blanco Blanco NNP cord-347946-i6kx3n6m 396 32 et et NNP cord-347946-i6kx3n6m 396 33 al al NNP cord-347946-i6kx3n6m 396 34 , , , cord-347946-i6kx3n6m 396 35 2012 2012 CD cord-347946-i6kx3n6m 396 36 ) ) -RRB- cord-347946-i6kx3n6m 396 37 . . . cord-347946-i6kx3n6m 397 1 How how WRB cord-347946-i6kx3n6m 397 2 might may MD cord-347946-i6kx3n6m 397 3 PATHOS pathos NN cord-347946-i6kx3n6m 397 4 - - HYPH cord-347946-i6kx3n6m 397 5 D d JJ cord-347946-i6kx3n6m 397 6 theory theory NN cord-347946-i6kx3n6m 397 7 seek seek VBP cord-347946-i6kx3n6m 397 8 to to TO cord-347946-i6kx3n6m 397 9 account account VB cord-347946-i6kx3n6m 397 10 for for IN cord-347946-i6kx3n6m 397 11 the the DT cord-347946-i6kx3n6m 397 12 existence existence NN cord-347946-i6kx3n6m 397 13 of of IN cord-347946-i6kx3n6m 397 14 these these DT cord-347946-i6kx3n6m 397 15 reversed reverse VBN cord-347946-i6kx3n6m 397 16 neurovegative neurovegative JJ cord-347946-i6kx3n6m 397 17 symptoms symptom NNS cord-347946-i6kx3n6m 397 18 , , , cord-347946-i6kx3n6m 397 19 as as RB cord-347946-i6kx3n6m 397 20 well well RB cord-347946-i6kx3n6m 397 21 as as IN cord-347946-i6kx3n6m 397 22 their -PRON- PRP$ cord-347946-i6kx3n6m 397 23 age age NN cord-347946-i6kx3n6m 397 24 and and CC cord-347946-i6kx3n6m 397 25 sex sex NN cord-347946-i6kx3n6m 397 26 distribution distribution NN cord-347946-i6kx3n6m 397 27 ? ? . cord-347946-i6kx3n6m 398 1 A a DT cord-347946-i6kx3n6m 398 2 first first JJ cord-347946-i6kx3n6m 398 3 step step NN cord-347946-i6kx3n6m 398 4 is be VBZ cord-347946-i6kx3n6m 398 5 to to TO cord-347946-i6kx3n6m 398 6 establish establish VB cord-347946-i6kx3n6m 398 7 that that DT cord-347946-i6kx3n6m 398 8 cytokine cytokine JJ cord-347946-i6kx3n6m 398 9 pathways pathway NNS cord-347946-i6kx3n6m 398 10 known know VBN cord-347946-i6kx3n6m 398 11 to to TO cord-347946-i6kx3n6m 398 12 be be VB cord-347946-i6kx3n6m 398 13 activated activate VBN cord-347946-i6kx3n6m 398 14 by by IN cord-347946-i6kx3n6m 398 15 infection infection NN cord-347946-i6kx3n6m 398 16 are be VBP cord-347946-i6kx3n6m 398 17 capable capable JJ cord-347946-i6kx3n6m 398 18 of of IN cord-347946-i6kx3n6m 398 19 producing produce VBG cord-347946-i6kx3n6m 398 20 both both DT cord-347946-i6kx3n6m 398 21 hypersomnia hypersomnia NNS cord-347946-i6kx3n6m 398 22 and and CC cord-347946-i6kx3n6m 398 23 hyperphagia hyperphagia NNP cord-347946-i6kx3n6m 398 24 . . . cord-347946-i6kx3n6m 399 1 Hypersomnia Hypersomnia NNP cord-347946-i6kx3n6m 399 2 has have VBZ cord-347946-i6kx3n6m 399 3 been be VBN cord-347946-i6kx3n6m 399 4 recognized recognize VBN cord-347946-i6kx3n6m 399 5 for for IN cord-347946-i6kx3n6m 399 6 years year NNS cord-347946-i6kx3n6m 399 7 as as IN cord-347946-i6kx3n6m 399 8 a a DT cord-347946-i6kx3n6m 399 9 primary primary JJ cord-347946-i6kx3n6m 399 10 behavioral behavioral JJ cord-347946-i6kx3n6m 399 11 manifestation manifestation NN cord-347946-i6kx3n6m 399 12 of of IN cord-347946-i6kx3n6m 399 13 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 399 14 cytokines cytokine NNS cord-347946-i6kx3n6m 399 15 ( ( -LRB- cord-347946-i6kx3n6m 399 16 Krueger Krueger NNP cord-347946-i6kx3n6m 399 17 and and CC cord-347946-i6kx3n6m 399 18 Majde Majde NNP cord-347946-i6kx3n6m 399 19 , , , cord-347946-i6kx3n6m 399 20 1994 1994 CD cord-347946-i6kx3n6m 399 21 ; ; : cord-347946-i6kx3n6m 399 22 Krueger Krueger NNP cord-347946-i6kx3n6m 399 23 and and CC cord-347946-i6kx3n6m 399 24 Toth Toth NNP cord-347946-i6kx3n6m 399 25 , , , cord-347946-i6kx3n6m 399 26 1994 1994 CD cord-347946-i6kx3n6m 399 27 ; ; : cord-347946-i6kx3n6m 399 28 Krueger Krueger NNP cord-347946-i6kx3n6m 399 29 and and CC cord-347946-i6kx3n6m 399 30 Majde Majde NNP cord-347946-i6kx3n6m 399 31 , , , cord-347946-i6kx3n6m 399 32 2003 2003 CD cord-347946-i6kx3n6m 399 33 ; ; : cord-347946-i6kx3n6m 399 34 Opp Opp NNP cord-347946-i6kx3n6m 399 35 , , , cord-347946-i6kx3n6m 399 36 2004 2004 CD cord-347946-i6kx3n6m 399 37 Opp Opp NNP cord-347946-i6kx3n6m 399 38 , , , cord-347946-i6kx3n6m 399 39 , , , cord-347946-i6kx3n6m 399 40 2009 2009 CD cord-347946-i6kx3n6m 399 41 , , , cord-347946-i6kx3n6m 399 42 and and CC cord-347946-i6kx3n6m 399 43 studies study NNS cord-347946-i6kx3n6m 399 44 in in IN cord-347946-i6kx3n6m 399 45 healthy healthy JJ cord-347946-i6kx3n6m 399 46 adolescents adolescent NNS cord-347946-i6kx3n6m 399 47 and and CC cord-347946-i6kx3n6m 399 48 adults adult NNS cord-347946-i6kx3n6m 399 49 indicate indicate VBP cord-347946-i6kx3n6m 399 50 that that IN cord-347946-i6kx3n6m 399 51 chronically chronically RB cord-347946-i6kx3n6m 399 52 increased increase VBN cord-347946-i6kx3n6m 399 53 sleep sleep NN cord-347946-i6kx3n6m 399 54 is be VBZ cord-347946-i6kx3n6m 399 55 associated associate VBN cord-347946-i6kx3n6m 399 56 with with IN cord-347946-i6kx3n6m 399 57 increased increase VBN cord-347946-i6kx3n6m 399 58 saliva saliva NN cord-347946-i6kx3n6m 399 59 and and CC cord-347946-i6kx3n6m 399 60 blood blood NN cord-347946-i6kx3n6m 399 61 concentrations concentration NNS cord-347946-i6kx3n6m 399 62 of of IN cord-347946-i6kx3n6m 399 63 IL-6 IL-6 NNP cord-347946-i6kx3n6m 399 64 and and CC cord-347946-i6kx3n6m 399 65 CRP CRP NNP cord-347946-i6kx3n6m 399 66 ( ( -LRB- cord-347946-i6kx3n6m 399 67 El El NNP cord-347946-i6kx3n6m 399 68 - - HYPH cord-347946-i6kx3n6m 399 69 Sheikh Sheikh NNP cord-347946-i6kx3n6m 399 70 et et NNP cord-347946-i6kx3n6m 399 71 al al NNP cord-347946-i6kx3n6m 399 72 , , , cord-347946-i6kx3n6m 399 73 2007 2007 CD cord-347946-i6kx3n6m 399 74 ; ; : cord-347946-i6kx3n6m 399 75 Patel Patel NNP cord-347946-i6kx3n6m 399 76 et et NNP cord-347946-i6kx3n6m 399 77 al al NNP cord-347946-i6kx3n6m 399 78 , , , cord-347946-i6kx3n6m 399 79 2009 2009 CD cord-347946-i6kx3n6m 399 80 ; ; : cord-347946-i6kx3n6m 399 81 Prather Prather NNP cord-347946-i6kx3n6m 399 82 et et NNP cord-347946-i6kx3n6m 399 83 al al NNP cord-347946-i6kx3n6m 399 84 , , , cord-347946-i6kx3n6m 399 85 2015 2015 CD cord-347946-i6kx3n6m 399 86 ) ) -RRB- cord-347946-i6kx3n6m 399 87 . . . cord-347946-i6kx3n6m 400 1 In in IN cord-347946-i6kx3n6m 400 2 terms term NNS cord-347946-i6kx3n6m 400 3 of of IN cord-347946-i6kx3n6m 400 4 feeding feeding NN cord-347946-i6kx3n6m 400 5 behavior behavior NN cord-347946-i6kx3n6m 400 6 , , , cord-347946-i6kx3n6m 400 7 animal animal NN cord-347946-i6kx3n6m 400 8 models model NNS cord-347946-i6kx3n6m 400 9 demonstrate demonstrate VBP cord-347946-i6kx3n6m 400 10 that that IN cord-347946-i6kx3n6m 400 11 inflammation inflammation NN cord-347946-i6kx3n6m 400 12 promotes promote VBZ cord-347946-i6kx3n6m 400 13 carbohydrate carbohydrate NN cord-347946-i6kx3n6m 400 14 preference preference NN cord-347946-i6kx3n6m 400 15 ( ( -LRB- cord-347946-i6kx3n6m 400 16 Aubert Aubert NNP cord-347946-i6kx3n6m 400 17 et et NNP cord-347946-i6kx3n6m 400 18 al al NNP cord-347946-i6kx3n6m 400 19 , , , cord-347946-i6kx3n6m 400 20 1995 1995 CD cord-347946-i6kx3n6m 400 21 ) ) -RRB- cord-347946-i6kx3n6m 400 22 , , , cord-347946-i6kx3n6m 400 23 such such JJ cord-347946-i6kx3n6m 400 24 as as IN cord-347946-i6kx3n6m 400 25 is be VBZ cord-347946-i6kx3n6m 400 26 typical typical JJ cord-347946-i6kx3n6m 400 27 in in IN cord-347946-i6kx3n6m 400 28 depressive depressive JJ cord-347946-i6kx3n6m 400 29 hyperphagia hyperphagia NN cord-347946-i6kx3n6m 400 30 . . . cord-347946-i6kx3n6m 401 1 Less less RBR cord-347946-i6kx3n6m 401 2 well well RB cord-347946-i6kx3n6m 401 3 known known JJ cord-347946-i6kx3n6m 401 4 are be VBP cord-347946-i6kx3n6m 401 5 data datum NNS cord-347946-i6kx3n6m 401 6 that that IN cord-347946-i6kx3n6m 401 7 highfat highfat JJ cord-347946-i6kx3n6m 401 8 diets diet NNS cord-347946-i6kx3n6m 401 9 induce induce VBP cord-347946-i6kx3n6m 401 10 leptin leptin NN cord-347946-i6kx3n6m 401 11 and and CC cord-347946-i6kx3n6m 401 12 insulin insulin NN cord-347946-i6kx3n6m 401 13 resistance resistance NN cord-347946-i6kx3n6m 401 14 , , , cord-347946-i6kx3n6m 401 15 as as RB cord-347946-i6kx3n6m 401 16 well well RB cord-347946-i6kx3n6m 401 17 as as IN cord-347946-i6kx3n6m 401 18 obesity obesity NN cord-347946-i6kx3n6m 401 19 , , , cord-347946-i6kx3n6m 401 20 dependent dependent JJ cord-347946-i6kx3n6m 401 21 upon upon IN cord-347946-i6kx3n6m 401 22 activation activation NN cord-347946-i6kx3n6m 401 23 of of IN cord-347946-i6kx3n6m 401 24 inflammatory inflammatory JJ cord-347946-i6kx3n6m 401 25 mediators mediator NNS cord-347946-i6kx3n6m 401 26 in in IN cord-347946-i6kx3n6m 401 27 the the DT cord-347946-i6kx3n6m 401 28 hypothalamus hypothalamus NN cord-347946-i6kx3n6m 401 29 ( ( -LRB- cord-347946-i6kx3n6m 401 30 Zhang Zhang NNP cord-347946-i6kx3n6m 401 31 et et NNP cord-347946-i6kx3n6m 401 32 al al NNP cord-347946-i6kx3n6m 401 33 , , , cord-347946-i6kx3n6m 401 34 2008 2008 CD cord-347946-i6kx3n6m 401 35 ; ; : cord-347946-i6kx3n6m 401 36 Kleinridders Kleinridders NNPS cord-347946-i6kx3n6m 401 37 et et NNP cord-347946-i6kx3n6m 401 38 al al NNP cord-347946-i6kx3n6m 401 39 , , , cord-347946-i6kx3n6m 401 40 2009 2009 CD cord-347946-i6kx3n6m 401 41 ) ) -RRB- cord-347946-i6kx3n6m 401 42 . . . cord-347946-i6kx3n6m 402 1 Conversely conversely RB cord-347946-i6kx3n6m 402 2 , , , cord-347946-i6kx3n6m 402 3 blocking block VBG cord-347946-i6kx3n6m 402 4 hypothalamic hypothalamic JJ cord-347946-i6kx3n6m 402 5 inflammation inflammation NN cord-347946-i6kx3n6m 402 6 prevents prevent VBZ cord-347946-i6kx3n6m 402 7 obesity obesity NN cord-347946-i6kx3n6m 402 8 and and CC cord-347946-i6kx3n6m 402 9 other other JJ cord-347946-i6kx3n6m 402 10 stigmata stigmata NN cord-347946-i6kx3n6m 402 11 of of IN cord-347946-i6kx3n6m 402 12 the the DT cord-347946-i6kx3n6m 402 13 metabolic metabolic JJ cord-347946-i6kx3n6m 402 14 syndrome syndrome NN cord-347946-i6kx3n6m 402 15 , , , cord-347946-i6kx3n6m 402 16 even even RB cord-347946-i6kx3n6m 402 17 in in IN cord-347946-i6kx3n6m 402 18 the the DT cord-347946-i6kx3n6m 402 19 context context NN cord-347946-i6kx3n6m 402 20 of of IN cord-347946-i6kx3n6m 402 21 high high JJ cord-347946-i6kx3n6m 402 22 - - HYPH cord-347946-i6kx3n6m 402 23 fat fat NN cord-347946-i6kx3n6m 402 24 consumption consumption NN cord-347946-i6kx3n6m 402 25 ( ( -LRB- cord-347946-i6kx3n6m 402 26 Zhang Zhang NNP cord-347946-i6kx3n6m 402 27 et et NNP cord-347946-i6kx3n6m 402 28 al al NNP cord-347946-i6kx3n6m 402 29 , , , cord-347946-i6kx3n6m 402 30 2008 2008 CD cord-347946-i6kx3n6m 402 31 ; ; : cord-347946-i6kx3n6m 402 32 Milanski Milanski NNP cord-347946-i6kx3n6m 402 33 et et NNP cord-347946-i6kx3n6m 402 34 al al NNP cord-347946-i6kx3n6m 402 35 , , , cord-347946-i6kx3n6m 402 36 2009 2009 CD cord-347946-i6kx3n6m 402 37 ; ; : cord-347946-i6kx3n6m 402 38 Posey Posey NNP cord-347946-i6kx3n6m 402 39 et et NNP cord-347946-i6kx3n6m 402 40 al al NNP cord-347946-i6kx3n6m 402 41 , , , cord-347946-i6kx3n6m 402 42 2009 2009 CD cord-347946-i6kx3n6m 402 43 ) ) -RRB- cord-347946-i6kx3n6m 402 44 . . . cord-347946-i6kx3n6m 403 1 In in IN cord-347946-i6kx3n6m 403 2 rodents rodent NNS cord-347946-i6kx3n6m 403 3 , , , cord-347946-i6kx3n6m 403 4 exposure exposure NN cord-347946-i6kx3n6m 403 5 to to IN cord-347946-i6kx3n6m 403 6 either either CC cord-347946-i6kx3n6m 403 7 TNF TNF NNP cord-347946-i6kx3n6m 403 8 or or CC cord-347946-i6kx3n6m 403 9 IL-6 IL-6 NNP cord-347946-i6kx3n6m 403 10 in in IN cord-347946-i6kx3n6m 403 11 utero utero NN cord-347946-i6kx3n6m 403 12 results result NNS cord-347946-i6kx3n6m 403 13 in in IN cord-347946-i6kx3n6m 403 14 adulthood adulthood NN cord-347946-i6kx3n6m 403 15 obesity obesity NN cord-347946-i6kx3n6m 403 16 ( ( -LRB- cord-347946-i6kx3n6m 403 17 Dahlgren Dahlgren NNP cord-347946-i6kx3n6m 403 18 et et FW cord-347946-i6kx3n6m 403 19 al al NNP cord-347946-i6kx3n6m 403 20 , , , cord-347946-i6kx3n6m 403 21 2001 2001 CD cord-347946-i6kx3n6m 403 22 ) ) -RRB- cord-347946-i6kx3n6m 403 23 , , , cord-347946-i6kx3n6m 403 24 again again RB cord-347946-i6kx3n6m 403 25 suggesting suggest VBG cord-347946-i6kx3n6m 403 26 that that IN cord-347946-i6kx3n6m 403 27 cytokines cytokine NNS cord-347946-i6kx3n6m 403 28 can can MD cord-347946-i6kx3n6m 403 29 induce induce VB cord-347946-i6kx3n6m 403 30 hyperphagia hyperphagia NNP cord-347946-i6kx3n6m 403 31 / / SYM cord-347946-i6kx3n6m 403 32 weight weight NN cord-347946-i6kx3n6m 403 33 gain gain NN cord-347946-i6kx3n6m 403 34 under under IN cord-347946-i6kx3n6m 403 35 certain certain JJ cord-347946-i6kx3n6m 403 36 circumstances circumstance NNS cord-347946-i6kx3n6m 403 37 . . . cord-347946-i6kx3n6m 404 1 Although although IN cord-347946-i6kx3n6m 404 2 we -PRON- PRP cord-347946-i6kx3n6m 404 3 know know VBP cord-347946-i6kx3n6m 404 4 of of IN cord-347946-i6kx3n6m 404 5 no no DT cord-347946-i6kx3n6m 404 6 data data NN cord-347946-i6kx3n6m 404 7 showing show VBG cord-347946-i6kx3n6m 404 8 that that IN cord-347946-i6kx3n6m 404 9 females female NNS cord-347946-i6kx3n6m 404 10 are be VBP cord-347946-i6kx3n6m 404 11 more more RBR cord-347946-i6kx3n6m 404 12 likely likely JJ cord-347946-i6kx3n6m 404 13 than than IN cord-347946-i6kx3n6m 404 14 males male NNS cord-347946-i6kx3n6m 404 15 to to TO cord-347946-i6kx3n6m 404 16 respond respond VB cord-347946-i6kx3n6m 404 17 to to IN cord-347946-i6kx3n6m 404 18 inflammatory inflammatory JJ cord-347946-i6kx3n6m 404 19 signaling signaling NN cord-347946-i6kx3n6m 404 20 with with IN cord-347946-i6kx3n6m 404 21 hyperphagia hyperphagia NNP cord-347946-i6kx3n6m 404 22 , , , cord-347946-i6kx3n6m 404 23 female female JJ cord-347946-i6kx3n6m 404 24 rodents rodent NNS cord-347946-i6kx3n6m 404 25 have have VBP cord-347946-i6kx3n6m 404 26 less less JJR cord-347946-i6kx3n6m 404 27 anorexia anorexia NN cord-347946-i6kx3n6m 404 28 than than IN cord-347946-i6kx3n6m 404 29 males male NNS cord-347946-i6kx3n6m 404 30 in in IN cord-347946-i6kx3n6m 404 31 response response NN cord-347946-i6kx3n6m 404 32 to to IN cord-347946-i6kx3n6m 404 33 influenza influenza NN cord-347946-i6kx3n6m 404 34 infection infection NN cord-347946-i6kx3n6m 405 1 ( ( -LRB- cord-347946-i6kx3n6m 405 2 Avitsur Avitsur NNP cord-347946-i6kx3n6m 405 3 et et NNP cord-347946-i6kx3n6m 405 4 al al NNP cord-347946-i6kx3n6m 405 5 , , , cord-347946-i6kx3n6m 405 6 2010 2010 CD cord-347946-i6kx3n6m 405 7 ) ) -RRB- cord-347946-i6kx3n6m 405 8 . . . cord-347946-i6kx3n6m 406 1 Because because IN cord-347946-i6kx3n6m 406 2 the the DT cord-347946-i6kx3n6m 406 3 presence presence NN cord-347946-i6kx3n6m 406 4 of of IN cord-347946-i6kx3n6m 406 5 widespread widespread JJ cord-347946-i6kx3n6m 406 6 obesity obesity NN cord-347946-i6kx3n6m 406 7 is be VBZ cord-347946-i6kx3n6m 406 8 recent recent JJ cord-347946-i6kx3n6m 406 9 , , , cord-347946-i6kx3n6m 406 10 the the DT cord-347946-i6kx3n6m 406 11 question question NN cord-347946-i6kx3n6m 406 12 arises arise VBZ cord-347946-i6kx3n6m 406 13 as as IN cord-347946-i6kx3n6m 406 14 to to IN cord-347946-i6kx3n6m 406 15 whether whether IN cord-347946-i6kx3n6m 406 16 more more JJR cord-347946-i6kx3n6m 406 17 ancient ancient JJ cord-347946-i6kx3n6m 406 18 signals signal NNS cord-347946-i6kx3n6m 406 19 for for IN cord-347946-i6kx3n6m 406 20 inflammatory inflammatory JJ cord-347946-i6kx3n6m 406 21 activation activation NN cord-347946-i6kx3n6m 406 22 might may MD cord-347946-i6kx3n6m 406 23 also also RB cord-347946-i6kx3n6m 406 24 promote promote VB cord-347946-i6kx3n6m 406 25 hyperphagia hyperphagia NNP cord-347946-i6kx3n6m 406 26 , , , cord-347946-i6kx3n6m 406 27 instead instead RB cord-347946-i6kx3n6m 406 28 of of IN cord-347946-i6kx3n6m 406 29 anorexia anorexia NN cord-347946-i6kx3n6m 406 30 . . . cord-347946-i6kx3n6m 407 1 We -PRON- PRP cord-347946-i6kx3n6m 407 2 know know VBP cord-347946-i6kx3n6m 407 3 of of IN cord-347946-i6kx3n6m 407 4 no no DT cord-347946-i6kx3n6m 407 5 data data NN cord-347946-i6kx3n6m 407 6 that that WDT cord-347946-i6kx3n6m 407 7 directly directly RB cord-347946-i6kx3n6m 407 8 address address VBP cord-347946-i6kx3n6m 407 9 this this DT cord-347946-i6kx3n6m 407 10 issue issue NN cord-347946-i6kx3n6m 407 11 in in IN cord-347946-i6kx3n6m 407 12 terms term NNS cord-347946-i6kx3n6m 407 13 of of IN cord-347946-i6kx3n6m 407 14 infection infection NN cord-347946-i6kx3n6m 407 15 , , , cord-347946-i6kx3n6m 407 16 but but CC cord-347946-i6kx3n6m 407 17 note note VB cord-347946-i6kx3n6m 407 18 that that IN cord-347946-i6kx3n6m 407 19 certain certain JJ cord-347946-i6kx3n6m 407 20 adenoviruses adenovirus NNS cord-347946-i6kx3n6m 407 21 have have VBP cord-347946-i6kx3n6m 407 22 been be VBN cord-347946-i6kx3n6m 407 23 associated associate VBN cord-347946-i6kx3n6m 407 24 with with IN cord-347946-i6kx3n6m 407 25 weight weight NN cord-347946-i6kx3n6m 407 26 gain gain NN cord-347946-i6kx3n6m 407 27 ( ( -LRB- cord-347946-i6kx3n6m 407 28 Atkinson Atkinson NNP cord-347946-i6kx3n6m 407 29 , , , cord-347946-i6kx3n6m 407 30 2008 2008 CD cord-347946-i6kx3n6m 407 31 ; ; : cord-347946-i6kx3n6m 407 32 Mitra Mitra NNP cord-347946-i6kx3n6m 407 33 and and CC cord-347946-i6kx3n6m 407 34 Clarke Clarke NNP cord-347946-i6kx3n6m 407 35 , , , cord-347946-i6kx3n6m 407 36 2010 2010 CD cord-347946-i6kx3n6m 407 37 ) ) -RRB- cord-347946-i6kx3n6m 407 38 . . . cord-347946-i6kx3n6m 408 1 In in IN cord-347946-i6kx3n6m 408 2 terms term NNS cord-347946-i6kx3n6m 408 3 of of IN cord-347946-i6kx3n6m 408 4 psychosocial psychosocial JJ cord-347946-i6kx3n6m 408 5 factors factor NNS cord-347946-i6kx3n6m 408 6 , , , cord-347946-i6kx3n6m 408 7 preclinical preclinical JJ cord-347946-i6kx3n6m 408 8 studies study NNS cord-347946-i6kx3n6m 408 9 suggest suggest VBP cord-347946-i6kx3n6m 408 10 that that IN cord-347946-i6kx3n6m 408 11 stressors stressor NNS cord-347946-i6kx3n6m 408 12 associated associate VBN cord-347946-i6kx3n6m 408 13 with with IN cord-347946-i6kx3n6m 408 14 a a DT cord-347946-i6kx3n6m 408 15 high high JJ cord-347946-i6kx3n6m 408 16 degree degree NN cord-347946-i6kx3n6m 408 17 of of IN cord-347946-i6kx3n6m 408 18 wounding wounding NN cord-347946-i6kx3n6m 408 19 - - , cord-347946-i6kx3n6m 408 20 such such JJ cord-347946-i6kx3n6m 408 21 as as IN cord-347946-i6kx3n6m 408 22 chronic chronic JJ cord-347946-i6kx3n6m 408 23 social social JJ cord-347946-i6kx3n6m 408 24 defeat defeat NN cord-347946-i6kx3n6m 409 1 -induce -induce NN cord-347946-i6kx3n6m 409 2 hypothalamic hypothalamic JJ cord-347946-i6kx3n6m 409 3 resistance resistance NN cord-347946-i6kx3n6m 409 4 to to IN cord-347946-i6kx3n6m 409 5 leptin leptin NN cord-347946-i6kx3n6m 410 1 ( ( -LRB- cord-347946-i6kx3n6m 410 2 Kleinridders Kleinridders NNP cord-347946-i6kx3n6m 410 3 et et NNP cord-347946-i6kx3n6m 410 4 al al NNP cord-347946-i6kx3n6m 410 5 , , , cord-347946-i6kx3n6m 410 6 2009 2009 CD cord-347946-i6kx3n6m 410 7 ; ; : cord-347946-i6kx3n6m 410 8 Chuang Chuang NNP cord-347946-i6kx3n6m 410 9 et et NNP cord-347946-i6kx3n6m 410 10 al al NNP cord-347946-i6kx3n6m 410 11 , , , cord-347946-i6kx3n6m 410 12 2010 2010 CD cord-347946-i6kx3n6m 410 13 ) ) -RRB- cord-347946-i6kx3n6m 410 14 , , , cord-347946-i6kx3n6m 410 15 consistent consistent JJ cord-347946-i6kx3n6m 410 16 with with IN cord-347946-i6kx3n6m 410 17 their -PRON- PRP$ cord-347946-i6kx3n6m 410 18 known know VBN cord-347946-i6kx3n6m 410 19 ability ability NN cord-347946-i6kx3n6m 410 20 to to TO cord-347946-i6kx3n6m 410 21 activate activate VB cord-347946-i6kx3n6m 410 22 inflammatory inflammatory JJ cord-347946-i6kx3n6m 410 23 pathways pathway NNS cord-347946-i6kx3n6m 410 24 ( ( -LRB- cord-347946-i6kx3n6m 410 25 Avitsur Avitsur NNP cord-347946-i6kx3n6m 410 26 et et NNP cord-347946-i6kx3n6m 410 27 al al NNP cord-347946-i6kx3n6m 410 28 , , , cord-347946-i6kx3n6m 410 29 2005 2005 CD cord-347946-i6kx3n6m 410 30 ; ; : cord-347946-i6kx3n6m 410 31 Bailey Bailey NNP cord-347946-i6kx3n6m 410 32 et et NNP cord-347946-i6kx3n6m 410 33 al al NNP cord-347946-i6kx3n6m 410 34 , , , cord-347946-i6kx3n6m 410 35 2007 2007 CD cord-347946-i6kx3n6m 410 36 Bailey Bailey NNP cord-347946-i6kx3n6m 410 37 et et NNP cord-347946-i6kx3n6m 410 38 al al NNP cord-347946-i6kx3n6m 410 39 , , , cord-347946-i6kx3n6m 410 40 , , , cord-347946-i6kx3n6m 410 41 2009 2009 CD cord-347946-i6kx3n6m 410 42 Powell Powell NNP cord-347946-i6kx3n6m 410 43 et et NNP cord-347946-i6kx3n6m 410 44 al al NNP cord-347946-i6kx3n6m 410 45 , , , cord-347946-i6kx3n6m 410 46 2010 2010 CD cord-347946-i6kx3n6m 410 47 ) ) -RRB- cord-347946-i6kx3n6m 410 48 . . . cord-347946-i6kx3n6m 411 1 As as IN cord-347946-i6kx3n6m 411 2 in in IN cord-347946-i6kx3n6m 411 3 depression depression NN cord-347946-i6kx3n6m 411 4 , , , cord-347946-i6kx3n6m 411 5 where where WRB cord-347946-i6kx3n6m 411 6 hyperphagia hyperphagia NNP cord-347946-i6kx3n6m 411 7 and and CC cord-347946-i6kx3n6m 411 8 weight weight NN cord-347946-i6kx3n6m 411 9 gain gain NN cord-347946-i6kx3n6m 411 10 are be VBP cord-347946-i6kx3n6m 411 11 associated associate VBN cord-347946-i6kx3n6m 411 12 with with IN cord-347946-i6kx3n6m 411 13 disease disease NN cord-347946-i6kx3n6m 411 14 chronicity chronicity NN cord-347946-i6kx3n6m 411 15 ( ( -LRB- cord-347946-i6kx3n6m 411 16 Posternak Posternak NNP cord-347946-i6kx3n6m 411 17 and and CC cord-347946-i6kx3n6m 411 18 Zimmerman Zimmerman NNP cord-347946-i6kx3n6m 411 19 , , , cord-347946-i6kx3n6m 411 20 2001 2001 CD cord-347946-i6kx3n6m 411 21 ) ) -RRB- cord-347946-i6kx3n6m 411 22 , , , cord-347946-i6kx3n6m 411 23 chronic chronic JJ cord-347946-i6kx3n6m 411 24 social social JJ cord-347946-i6kx3n6m 411 25 defeat defeat NN cord-347946-i6kx3n6m 411 26 leads lead VBZ cord-347946-i6kx3n6m 411 27 initially initially RB cord-347946-i6kx3n6m 411 28 to to IN cord-347946-i6kx3n6m 411 29 weight weight NN cord-347946-i6kx3n6m 411 30 loss loss NN cord-347946-i6kx3n6m 411 31 but but CC cord-347946-i6kx3n6m 411 32 to to TO cord-347946-i6kx3n6m 411 33 weight weight NN cord-347946-i6kx3n6m 411 34 gain gain NN cord-347946-i6kx3n6m 411 35 over over IN cord-347946-i6kx3n6m 411 36 time time NN cord-347946-i6kx3n6m 412 1 ( ( -LRB- cord-347946-i6kx3n6m 412 2 Chuang Chuang NNP cord-347946-i6kx3n6m 412 3 et et NNP cord-347946-i6kx3n6m 412 4 al al NNP cord-347946-i6kx3n6m 412 5 , , , cord-347946-i6kx3n6m 412 6 2010 2010 CD cord-347946-i6kx3n6m 412 7 ) ) -RRB- cord-347946-i6kx3n6m 412 8 . . . cord-347946-i6kx3n6m 413 1 Given give VBN cord-347946-i6kx3n6m 413 2 the the DT cord-347946-i6kx3n6m 413 3 role role NN cord-347946-i6kx3n6m 413 4 of of IN cord-347946-i6kx3n6m 413 5 leptin leptin NN cord-347946-i6kx3n6m 413 6 resistance resistance NN cord-347946-i6kx3n6m 413 7 in in IN cord-347946-i6kx3n6m 413 8 hyperphagia hyperphagia NNP cord-347946-i6kx3n6m 413 9 , , , cord-347946-i6kx3n6m 413 10 it -PRON- PRP cord-347946-i6kx3n6m 413 11 is be VBZ cord-347946-i6kx3n6m 413 12 intriguing intriguing JJ cord-347946-i6kx3n6m 413 13 that that IN cord-347946-i6kx3n6m 413 14 increased increase VBN cord-347946-i6kx3n6m 413 15 peripheral peripheral JJ cord-347946-i6kx3n6m 413 16 leptin leptin NN cord-347946-i6kx3n6m 413 17 levels level NNS cord-347946-i6kx3n6m 413 18 ( ( -LRB- cord-347946-i6kx3n6m 413 19 consistent consistent JJ cord-347946-i6kx3n6m 413 20 with with IN cord-347946-i6kx3n6m 413 21 leptin leptin NN cord-347946-i6kx3n6m 413 22 resistance resistance NN cord-347946-i6kx3n6m 413 23 ) ) -RRB- cord-347946-i6kx3n6m 413 24 have have VBP cord-347946-i6kx3n6m 413 25 been be VBN cord-347946-i6kx3n6m 413 26 observed observe VBN cord-347946-i6kx3n6m 413 27 more more RBR cord-347946-i6kx3n6m 413 28 consistently consistently RB cord-347946-i6kx3n6m 413 29 in in IN cord-347946-i6kx3n6m 413 30 females female NNS cord-347946-i6kx3n6m 413 31 than than IN cord-347946-i6kx3n6m 413 32 in in IN cord-347946-i6kx3n6m 413 33 males male NNS cord-347946-i6kx3n6m 413 34 with with IN cord-347946-i6kx3n6m 413 35 MDD MDD NNP cord-347946-i6kx3n6m 414 1 ( ( -LRB- cord-347946-i6kx3n6m 414 2 Rubin Rubin NNP cord-347946-i6kx3n6m 414 3 et et NNP cord-347946-i6kx3n6m 414 4 al al NNP cord-347946-i6kx3n6m 414 5 , , , cord-347946-i6kx3n6m 414 6 2002 2002 CD cord-347946-i6kx3n6m 414 7 ; ; : cord-347946-i6kx3n6m 414 8 Yang Yang NNP cord-347946-i6kx3n6m 414 9 et et NNP cord-347946-i6kx3n6m 414 10 al al NNP cord-347946-i6kx3n6m 414 11 , , , cord-347946-i6kx3n6m 414 12 2007 2007 CD cord-347946-i6kx3n6m 414 13 ; ; : cord-347946-i6kx3n6m 414 14 Pasco Pasco NNP cord-347946-i6kx3n6m 414 15 et et NNP cord-347946-i6kx3n6m 414 16 al al NNP cord-347946-i6kx3n6m 414 17 , , , cord-347946-i6kx3n6m 414 18 2008 2008 CD cord-347946-i6kx3n6m 414 19 ; ; : cord-347946-i6kx3n6m 414 20 Zeman Zeman NNP cord-347946-i6kx3n6m 414 21 et et NNP cord-347946-i6kx3n6m 414 22 al al NNP cord-347946-i6kx3n6m 414 23 , , , cord-347946-i6kx3n6m 414 24 2009 2009 CD cord-347946-i6kx3n6m 414 25 ; ; : cord-347946-i6kx3n6m 414 26 Cizza Cizza NNP cord-347946-i6kx3n6m 414 27 et et NNP cord-347946-i6kx3n6m 414 28 al al NNP cord-347946-i6kx3n6m 414 29 , , , cord-347946-i6kx3n6m 414 30 2010 2010 CD cord-347946-i6kx3n6m 414 31 ) ) -RRB- cord-347946-i6kx3n6m 414 32 , , , cord-347946-i6kx3n6m 414 33 and and CC cord-347946-i6kx3n6m 414 34 are be VBP cord-347946-i6kx3n6m 414 35 more more RBR cord-347946-i6kx3n6m 414 36 common common JJ cord-347946-i6kx3n6m 414 37 in in IN cord-347946-i6kx3n6m 414 38 atypical atypical JJ cord-347946-i6kx3n6m 414 39 than than IN cord-347946-i6kx3n6m 414 40 non non JJ cord-347946-i6kx3n6m 414 41 - - JJ cord-347946-i6kx3n6m 414 42 atypical atypical JJ cord-347946-i6kx3n6m 414 43 depression depression NN cord-347946-i6kx3n6m 414 44 ( ( -LRB- cord-347946-i6kx3n6m 414 45 Gecici Gecici NNP cord-347946-i6kx3n6m 414 46 et et NNP cord-347946-i6kx3n6m 414 47 al al NNP cord-347946-i6kx3n6m 414 48 , , , cord-347946-i6kx3n6m 414 49 2005 2005 CD cord-347946-i6kx3n6m 414 50 ) ) -RRB- cord-347946-i6kx3n6m 414 51 . . . cord-347946-i6kx3n6m 415 1 Why why WRB cord-347946-i6kx3n6m 415 2 might may MD cord-347946-i6kx3n6m 415 3 younger young JJR cord-347946-i6kx3n6m 415 4 individuals individual NNS cord-347946-i6kx3n6m 415 5 in in IN cord-347946-i6kx3n6m 415 6 general general JJ cord-347946-i6kx3n6m 415 7 , , , cord-347946-i6kx3n6m 415 8 and and CC cord-347946-i6kx3n6m 415 9 females female NNS cord-347946-i6kx3n6m 415 10 in in IN cord-347946-i6kx3n6m 415 11 particular particular JJ cord-347946-i6kx3n6m 415 12 , , , cord-347946-i6kx3n6m 415 13 be be VB cord-347946-i6kx3n6m 415 14 more more RBR cord-347946-i6kx3n6m 415 15 likely likely JJ cord-347946-i6kx3n6m 415 16 to to TO cord-347946-i6kx3n6m 415 17 develop develop VB cord-347946-i6kx3n6m 415 18 depressive depressive JJ cord-347946-i6kx3n6m 415 19 conditions condition NNS cord-347946-i6kx3n6m 415 20 characterized characterize VBN cord-347946-i6kx3n6m 415 21 by by IN cord-347946-i6kx3n6m 415 22 hypersomnia hypersomnia NNP cord-347946-i6kx3n6m 415 23 and and CC cord-347946-i6kx3n6m 415 24 hyperphagia hyperphagia NNP cord-347946-i6kx3n6m 415 25 ? ? . cord-347946-i6kx3n6m 416 1 From from IN cord-347946-i6kx3n6m 416 2 a a DT cord-347946-i6kx3n6m 416 3 PATHOS pathos NN cord-347946-i6kx3n6m 416 4 - - HYPH cord-347946-i6kx3n6m 416 5 D d JJ cord-347946-i6kx3n6m 416 6 perspective perspective NN cord-347946-i6kx3n6m 416 7 , , , cord-347946-i6kx3n6m 416 8 the the DT cord-347946-i6kx3n6m 416 9 simplest simple JJS cord-347946-i6kx3n6m 416 10 answer answer NN cord-347946-i6kx3n6m 416 11 may may MD cord-347946-i6kx3n6m 416 12 be be VB cord-347946-i6kx3n6m 416 13 : : : cord-347946-i6kx3n6m 416 14 because because IN cord-347946-i6kx3n6m 416 15 they -PRON- PRP cord-347946-i6kx3n6m 416 16 can can MD cord-347946-i6kx3n6m 416 17 . . . cord-347946-i6kx3n6m 417 1 In in IN cord-347946-i6kx3n6m 417 2 hunter hunter NN cord-347946-i6kx3n6m 417 3 - - HYPH cord-347946-i6kx3n6m 417 4 gatherer gatherer NN cord-347946-i6kx3n6m 417 5 societies society NNS cord-347946-i6kx3n6m 417 6 youth youth NN cord-347946-i6kx3n6m 417 7 and and CC cord-347946-i6kx3n6m 417 8 females female NNS cord-347946-i6kx3n6m 417 9 are be VBP cord-347946-i6kx3n6m 417 10 frequently frequently RB cord-347946-i6kx3n6m 417 11 more more RBR cord-347946-i6kx3n6m 417 12 protected protect VBN cord-347946-i6kx3n6m 417 13 from from IN cord-347946-i6kx3n6m 417 14 predation predation NN cord-347946-i6kx3n6m 417 15 and and CC cord-347946-i6kx3n6m 417 16 to to TO cord-347946-i6kx3n6m 417 17 have have VB cord-347946-i6kx3n6m 417 18 food food NN cord-347946-i6kx3n6m 417 19 supplied supply VBN cord-347946-i6kx3n6m 417 20 to to IN cord-347946-i6kx3n6m 417 21 them -PRON- PRP cord-347946-i6kx3n6m 417 22 by by IN cord-347946-i6kx3n6m 417 23 others other NNS cord-347946-i6kx3n6m 417 24 ( ( -LRB- cord-347946-i6kx3n6m 417 25 Kaplan Kaplan NNP cord-347946-i6kx3n6m 417 26 and and CC cord-347946-i6kx3n6m 417 27 Gurven Gurven NNP cord-347946-i6kx3n6m 417 28 , , , cord-347946-i6kx3n6m 417 29 2005 2005 CD cord-347946-i6kx3n6m 417 30 ) ) -RRB- cord-347946-i6kx3n6m 417 31 , , , cord-347946-i6kx3n6m 417 32 raising raise VBG cord-347946-i6kx3n6m 417 33 the the DT cord-347946-i6kx3n6m 417 34 possibility possibility NN cord-347946-i6kx3n6m 417 35 that that IN cord-347946-i6kx3n6m 417 36 in in IN cord-347946-i6kx3n6m 417 37 ancestral ancestral JJ cord-347946-i6kx3n6m 417 38 environments environment NNS cord-347946-i6kx3n6m 417 39 these these DT cord-347946-i6kx3n6m 417 40 individuals individual NNS cord-347946-i6kx3n6m 417 41 enjoyed enjoy VBD cord-347946-i6kx3n6m 417 42 sufficient sufficient JJ cord-347946-i6kx3n6m 417 43 security security NN cord-347946-i6kx3n6m 417 44 to to TO cord-347946-i6kx3n6m 417 45 partake partake VB cord-347946-i6kx3n6m 417 46 of of IN cord-347946-i6kx3n6m 417 47 the the DT cord-347946-i6kx3n6m 417 48 recuperative recuperative JJ cord-347946-i6kx3n6m 417 49 effects effect NNS cord-347946-i6kx3n6m 417 50 of of IN cord-347946-i6kx3n6m 417 51 sleep sleep NN cord-347946-i6kx3n6m 417 52 and and CC cord-347946-i6kx3n6m 417 53 to to TO cord-347946-i6kx3n6m 417 54 eat eat VB cord-347946-i6kx3n6m 417 55 without without IN cord-347946-i6kx3n6m 417 56 having have VBG cord-347946-i6kx3n6m 417 57 to to TO cord-347946-i6kx3n6m 417 58 expend expend VB cord-347946-i6kx3n6m 417 59 energy energy NN cord-347946-i6kx3n6m 417 60 searching search VBG cord-347946-i6kx3n6m 417 61 for for IN cord-347946-i6kx3n6m 417 62 food food NN cord-347946-i6kx3n6m 417 63 . . . cord-347946-i6kx3n6m 418 1 Given give VBN cord-347946-i6kx3n6m 418 2 evidence evidence NN cord-347946-i6kx3n6m 418 3 that that IN cord-347946-i6kx3n6m 418 4 anorexia anorexia NN cord-347946-i6kx3n6m 418 5 may may MD cord-347946-i6kx3n6m 418 6 confer confer VB cord-347946-i6kx3n6m 418 7 anti anti JJ cord-347946-i6kx3n6m 418 8 - - JJ cord-347946-i6kx3n6m 418 9 pathogen pathogen JJ cord-347946-i6kx3n6m 418 10 effects effect NNS cord-347946-i6kx3n6m 418 11 ( ( -LRB- cord-347946-i6kx3n6m 418 12 Raison Raison NNP cord-347946-i6kx3n6m 418 13 and and CC cord-347946-i6kx3n6m 418 14 Miller Miller NNP cord-347946-i6kx3n6m 418 15 , , , cord-347946-i6kx3n6m 418 16 2012 2012 CD cord-347946-i6kx3n6m 418 17 ) ) -RRB- cord-347946-i6kx3n6m 418 18 , , , cord-347946-i6kx3n6m 418 19 might may MD cord-347946-i6kx3n6m 418 20 similar similar JJ cord-347946-i6kx3n6m 418 21 benefits benefit NNS cord-347946-i6kx3n6m 418 22 accrue accrue JJ cord-347946-i6kx3n6m 418 23 to to IN cord-347946-i6kx3n6m 418 24 hyperphagia hyperphagia NNP cord-347946-i6kx3n6m 418 25 , , , cord-347946-i6kx3n6m 418 26 especially especially RB cord-347946-i6kx3n6m 418 27 in in IN cord-347946-i6kx3n6m 418 28 youth youth NN cord-347946-i6kx3n6m 418 29 and and CC cord-347946-i6kx3n6m 418 30 females female NNS cord-347946-i6kx3n6m 418 31 , , , cord-347946-i6kx3n6m 418 32 under under IN cord-347946-i6kx3n6m 418 33 at at IN cord-347946-i6kx3n6m 418 34 least least JJS cord-347946-i6kx3n6m 418 35 some some DT cord-347946-i6kx3n6m 418 36 evolutionarily evolutionarily RB cord-347946-i6kx3n6m 418 37 relevant relevant JJ cord-347946-i6kx3n6m 418 38 situations situation NNS cord-347946-i6kx3n6m 418 39 ? ? . cord-347946-i6kx3n6m 419 1 Although although IN cord-347946-i6kx3n6m 419 2 admittedly admittedly RB cord-347946-i6kx3n6m 419 3 speculative speculative JJ cord-347946-i6kx3n6m 419 4 , , , cord-347946-i6kx3n6m 419 5 several several JJ cord-347946-i6kx3n6m 419 6 lines line NNS cord-347946-i6kx3n6m 419 7 of of IN cord-347946-i6kx3n6m 419 8 evidence evidence NN cord-347946-i6kx3n6m 419 9 suggest suggest VBP cord-347946-i6kx3n6m 419 10 that that IN cord-347946-i6kx3n6m 419 11 by by IN cord-347946-i6kx3n6m 419 12 promoting promote VBG cord-347946-i6kx3n6m 419 13 hypothalamic hypothalamic JJ cord-347946-i6kx3n6m 419 14 resistance resistance NN cord-347946-i6kx3n6m 419 15 to to IN cord-347946-i6kx3n6m 419 16 leptin leptin NN cord-347946-i6kx3n6m 419 17 , , , cord-347946-i6kx3n6m 419 18 genes gene NNS cord-347946-i6kx3n6m 419 19 associated associate VBN cord-347946-i6kx3n6m 419 20 with with IN cord-347946-i6kx3n6m 419 21 increased increase VBN cord-347946-i6kx3n6m 419 22 inflammatory inflammatory JJ cord-347946-i6kx3n6m 419 23 signaling signaling NN cord-347946-i6kx3n6m 419 24 might may MD cord-347946-i6kx3n6m 419 25 enhance enhance VB cord-347946-i6kx3n6m 419 26 host host NN cord-347946-i6kx3n6m 419 27 defense defense NN cord-347946-i6kx3n6m 419 28 by by IN cord-347946-i6kx3n6m 419 29 driving drive VBG cord-347946-i6kx3n6m 419 30 ongoing ongoing JJ cord-347946-i6kx3n6m 419 31 leptin leptin NN cord-347946-i6kx3n6m 419 32 production production NN cord-347946-i6kx3n6m 419 33 despite despite IN cord-347946-i6kx3n6m 419 34 malnutrition malnutrition NN cord-347946-i6kx3n6m 419 35 in in IN cord-347946-i6kx3n6m 419 36 conditions condition NNS cord-347946-i6kx3n6m 419 37 of of IN cord-347946-i6kx3n6m 419 38 food food NN cord-347946-i6kx3n6m 419 39 scarcity scarcity NN cord-347946-i6kx3n6m 419 40 . . . cord-347946-i6kx3n6m 420 1 This this DT cord-347946-i6kx3n6m 420 2 increased increase VBN cord-347946-i6kx3n6m 420 3 leptin leptin NN cord-347946-i6kx3n6m 420 4 production production NN cord-347946-i6kx3n6m 420 5 would would MD cord-347946-i6kx3n6m 420 6 both both DT cord-347946-i6kx3n6m 420 7 augment augment VB cord-347946-i6kx3n6m 420 8 the the DT cord-347946-i6kx3n6m 420 9 drive drive NN cord-347946-i6kx3n6m 420 10 to to TO cord-347946-i6kx3n6m 420 11 seek seek VB cord-347946-i6kx3n6m 420 12 and and CC cord-347946-i6kx3n6m 420 13 consume consume VB cord-347946-i6kx3n6m 420 14 food food NN cord-347946-i6kx3n6m 420 15 and and CC cord-347946-i6kx3n6m 420 16 would would MD cord-347946-i6kx3n6m 420 17 lower lower VB cord-347946-i6kx3n6m 420 18 the the DT cord-347946-i6kx3n6m 420 19 set set NN cord-347946-i6kx3n6m 420 20 point point NN cord-347946-i6kx3n6m 420 21 at at IN cord-347946-i6kx3n6m 420 22 which which WDT cord-347946-i6kx3n6m 420 23 food food NN cord-347946-i6kx3n6m 420 24 consumption consumption NN cord-347946-i6kx3n6m 420 25 initiated initiate VBD cord-347946-i6kx3n6m 420 26 the the DT cord-347946-i6kx3n6m 420 27 types type NNS cord-347946-i6kx3n6m 420 28 of of IN cord-347946-i6kx3n6m 420 29 inflammatory inflammatory JJ cord-347946-i6kx3n6m 420 30 responses response NNS cord-347946-i6kx3n6m 420 31 that that WDT cord-347946-i6kx3n6m 420 32 are be VBP cord-347946-i6kx3n6m 420 33 all all RB cord-347946-i6kx3n6m 420 34 too too RB cord-347946-i6kx3n6m 420 35 common common JJ cord-347946-i6kx3n6m 420 36 in in IN cord-347946-i6kx3n6m 420 37 the the DT cord-347946-i6kx3n6m 420 38 obese obese NN cord-347946-i6kx3n6m 420 39 , , , cord-347946-i6kx3n6m 420 40 but but CC cord-347946-i6kx3n6m 420 41 that that DT cord-347946-i6kx3n6m 420 42 appear appear VBP cord-347946-i6kx3n6m 420 43 to to TO cord-347946-i6kx3n6m 420 44 be be VB cord-347946-i6kx3n6m 420 45 life life NN cord-347946-i6kx3n6m 420 46 - - HYPH cord-347946-i6kx3n6m 420 47 saving saving NN cord-347946-i6kx3n6m 420 48 in in IN cord-347946-i6kx3n6m 420 49 the the DT cord-347946-i6kx3n6m 420 50 face face NN cord-347946-i6kx3n6m 420 51 of of IN cord-347946-i6kx3n6m 420 52 an an DT cord-347946-i6kx3n6m 420 53 infection infection NN cord-347946-i6kx3n6m 420 54 such such JJ cord-347946-i6kx3n6m 420 55 as as IN cord-347946-i6kx3n6m 420 56 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 420 57 , , , cord-347946-i6kx3n6m 420 58 that that DT cord-347946-i6kx3n6m 420 59 was be VBD cord-347946-i6kx3n6m 420 60 ( ( -LRB- cord-347946-i6kx3n6m 420 61 and and CC cord-347946-i6kx3n6m 420 62 is be VBZ cord-347946-i6kx3n6m 420 63 ) ) -RRB- cord-347946-i6kx3n6m 420 64 most most RBS cord-347946-i6kx3n6m 420 65 lethal lethal JJ cord-347946-i6kx3n6m 420 66 for for IN cord-347946-i6kx3n6m 420 67 females female NNS cord-347946-i6kx3n6m 420 68 of of IN cord-347946-i6kx3n6m 420 69 reproductive reproductive JJ cord-347946-i6kx3n6m 420 70 age age NN cord-347946-i6kx3n6m 420 71 and and CC cord-347946-i6kx3n6m 420 72 for for IN cord-347946-i6kx3n6m 420 73 which which WDT cord-347946-i6kx3n6m 420 74 low low JJ cord-347946-i6kx3n6m 420 75 body body NN cord-347946-i6kx3n6m 420 76 weight weight NN cord-347946-i6kx3n6m 420 77 and and CC cord-347946-i6kx3n6m 420 78 reduced reduced JJ cord-347946-i6kx3n6m 420 79 leptin leptin NN cord-347946-i6kx3n6m 420 80 are be VBP cord-347946-i6kx3n6m 420 81 deadly deadly JJ cord-347946-i6kx3n6m 420 82 ( ( -LRB- cord-347946-i6kx3n6m 420 83 van van NNP cord-347946-i6kx3n6m 420 84 Crevel Crevel NNP cord-347946-i6kx3n6m 420 85 et et NNP cord-347946-i6kx3n6m 420 86 al al NNP cord-347946-i6kx3n6m 420 87 , , , cord-347946-i6kx3n6m 420 88 2002 2002 CD cord-347946-i6kx3n6m 420 89 ; ; : cord-347946-i6kx3n6m 421 1 Wieland Wieland NNP cord-347946-i6kx3n6m 421 2 et et NNP cord-347946-i6kx3n6m 421 3 al al NNP cord-347946-i6kx3n6m 421 4 , , , cord-347946-i6kx3n6m 421 5 2005 2005 CD cord-347946-i6kx3n6m 421 6 ; ; : cord-347946-i6kx3n6m 421 7 Buyukoglan Buyukoglan NNP cord-347946-i6kx3n6m 421 8 et et NNP cord-347946-i6kx3n6m 421 9 al al NNP cord-347946-i6kx3n6m 421 10 , , , cord-347946-i6kx3n6m 421 11 2007 2007 CD cord-347946-i6kx3n6m 421 12 ; ; : cord-347946-i6kx3n6m 421 13 Leung Leung NNP cord-347946-i6kx3n6m 421 14 et et NNP cord-347946-i6kx3n6m 421 15 al al NNP cord-347946-i6kx3n6m 421 16 , , , cord-347946-i6kx3n6m 421 17 2007 2007 CD cord-347946-i6kx3n6m 421 18 ; ; : cord-347946-i6kx3n6m 421 19 Pednekar Pednekar NNP cord-347946-i6kx3n6m 421 20 et et NNP cord-347946-i6kx3n6m 421 21 al al NNP cord-347946-i6kx3n6m 421 22 , , , cord-347946-i6kx3n6m 421 23 2008 2008 CD cord-347946-i6kx3n6m 421 24 ; ; : cord-347946-i6kx3n6m 422 1 Roth Roth NNP cord-347946-i6kx3n6m 422 2 , , , cord-347946-i6kx3n6m 422 3 2009 2009 CD cord-347946-i6kx3n6m 422 4 ) ) -RRB- cord-347946-i6kx3n6m 422 5 . . . cord-347946-i6kx3n6m 423 1 Depression depression NN cord-347946-i6kx3n6m 423 2 and and CC cord-347946-i6kx3n6m 423 3 anxiety anxiety NN cord-347946-i6kx3n6m 423 4 are be VBP cord-347946-i6kx3n6m 423 5 highly highly RB cord-347946-i6kx3n6m 423 6 comorbid comorbid JJ cord-347946-i6kx3n6m 423 7 , , , cord-347946-i6kx3n6m 423 8 and and CC cord-347946-i6kx3n6m 423 9 in in IN cord-347946-i6kx3n6m 423 10 both both DT cord-347946-i6kx3n6m 423 11 animals animal NNS cord-347946-i6kx3n6m 423 12 and and CC cord-347946-i6kx3n6m 423 13 humans human NNS cord-347946-i6kx3n6m 423 14 , , , cord-347946-i6kx3n6m 423 15 activation activation NN cord-347946-i6kx3n6m 423 16 of of IN cord-347946-i6kx3n6m 423 17 the the DT cord-347946-i6kx3n6m 423 18 inflammatory inflammatory JJ cord-347946-i6kx3n6m 423 19 response response NN cord-347946-i6kx3n6m 423 20 produces produce VBZ cord-347946-i6kx3n6m 423 21 both both DT cord-347946-i6kx3n6m 423 22 types type NNS cord-347946-i6kx3n6m 423 23 of of IN cord-347946-i6kx3n6m 423 24 symptoms symptom NNS cord-347946-i6kx3n6m 423 25 . . . cord-347946-i6kx3n6m 424 1 In in IN cord-347946-i6kx3n6m 424 2 a a DT cord-347946-i6kx3n6m 424 3 previous previous JJ cord-347946-i6kx3n6m 424 4 publication publication NN cord-347946-i6kx3n6m 424 5 , , , cord-347946-i6kx3n6m 424 6 we -PRON- PRP cord-347946-i6kx3n6m 424 7 devoted devote VBD cord-347946-i6kx3n6m 424 8 significant significant JJ cord-347946-i6kx3n6m 424 9 space space NN cord-347946-i6kx3n6m 424 10 to to IN cord-347946-i6kx3n6m 424 11 providing provide VBG cord-347946-i6kx3n6m 424 12 a a DT cord-347946-i6kx3n6m 424 13 PATHOS pathos NN cord-347946-i6kx3n6m 424 14 - - HYPH cord-347946-i6kx3n6m 424 15 D d JJ cord-347946-i6kx3n6m 424 16 perspective perspective NN cord-347946-i6kx3n6m 424 17 on on IN cord-347946-i6kx3n6m 424 18 why why WRB cord-347946-i6kx3n6m 424 19 inflammation inflammation NN cord-347946-i6kx3n6m 424 20 produces produce VBZ cord-347946-i6kx3n6m 424 21 changes change NNS cord-347946-i6kx3n6m 424 22 in in IN cord-347946-i6kx3n6m 424 23 brain brain NN cord-347946-i6kx3n6m 424 24 function function NN cord-347946-i6kx3n6m 424 25 that that WDT cord-347946-i6kx3n6m 424 26 subserve subserve NN cord-347946-i6kx3n6m 424 27 not not RB cord-347946-i6kx3n6m 424 28 just just RB cord-347946-i6kx3n6m 424 29 conservation conservation NN cord-347946-i6kx3n6m 424 30 - - HYPH cord-347946-i6kx3n6m 424 31 withdrawal withdrawal NN cord-347946-i6kx3n6m 424 32 symptoms symptom NNS cord-347946-i6kx3n6m 424 33 likely likely JJ cord-347946-i6kx3n6m 424 34 to to TO cord-347946-i6kx3n6m 424 35 aid aid VB cord-347946-i6kx3n6m 424 36 in in IN cord-347946-i6kx3n6m 424 37 defense defense NN cord-347946-i6kx3n6m 424 38 against against IN cord-347946-i6kx3n6m 424 39 pathogens pathogen NNS cord-347946-i6kx3n6m 424 40 , , , cord-347946-i6kx3n6m 424 41 but but CC cord-347946-i6kx3n6m 424 42 that that DT cord-347946-i6kx3n6m 424 43 also also RB cord-347946-i6kx3n6m 424 44 have have VBP cord-347946-i6kx3n6m 424 45 been be VBN cord-347946-i6kx3n6m 424 46 associated associate VBN cord-347946-i6kx3n6m 424 47 with with IN cord-347946-i6kx3n6m 424 48 hypervigilance hypervigilance NN cord-347946-i6kx3n6m 424 49 symptoms symptom NNS cord-347946-i6kx3n6m 424 50 ( ( -LRB- cord-347946-i6kx3n6m 424 51 eg eg RB cord-347946-i6kx3n6m 424 52 , , , cord-347946-i6kx3n6m 424 53 anxiety anxiety NN cord-347946-i6kx3n6m 424 54 / / SYM cord-347946-i6kx3n6m 424 55 agitation agitation NN cord-347946-i6kx3n6m 424 56 , , , cord-347946-i6kx3n6m 424 57 insomnia insomnia NN cord-347946-i6kx3n6m 424 58 , , , cord-347946-i6kx3n6m 424 59 anger anger NN cord-347946-i6kx3n6m 424 60 / / SYM cord-347946-i6kx3n6m 424 61 irritability irritability NN cord-347946-i6kx3n6m 424 62 ( ( -LRB- cord-347946-i6kx3n6m 424 63 Association Association NNP cord-347946-i6kx3n6m 424 64 AP AP NNP cord-347946-i6kx3n6m 424 65 , , , cord-347946-i6kx3n6m 424 66 2013 2013 CD cord-347946-i6kx3n6m 424 67 ) ) -RRB- cord-347946-i6kx3n6m 424 68 ) ) -RRB- cord-347946-i6kx3n6m 424 69 that that IN cord-347946-i6kx3n6m 424 70 across across IN cord-347946-i6kx3n6m 424 71 human human JJ cord-347946-i6kx3n6m 424 72 evolution evolution NN cord-347946-i6kx3n6m 424 73 would would MD cord-347946-i6kx3n6m 424 74 have have VB cord-347946-i6kx3n6m 424 75 presumably presumably RB cord-347946-i6kx3n6m 424 76 siphoned siphon VBN cord-347946-i6kx3n6m 424 77 metabolic metabolic JJ cord-347946-i6kx3n6m 424 78 resources resource NNS cord-347946-i6kx3n6m 424 79 away away RB cord-347946-i6kx3n6m 424 80 from from IN cord-347946-i6kx3n6m 424 81 the the DT cord-347946-i6kx3n6m 424 82 life life NN cord-347946-i6kx3n6m 424 83 - - HYPH cord-347946-i6kx3n6m 424 84 or or CC cord-347946-i6kx3n6m 424 85 - - HYPH cord-347946-i6kx3n6m 424 86 death death NN cord-347946-i6kx3n6m 424 87 task task NN cord-347946-i6kx3n6m 424 88 of of IN cord-347946-i6kx3n6m 424 89 immune immune JJ cord-347946-i6kx3n6m 424 90 protection protection NN cord-347946-i6kx3n6m 424 91 ( ( -LRB- cord-347946-i6kx3n6m 424 92 Raison Raison NNP cord-347946-i6kx3n6m 424 93 and and CC cord-347946-i6kx3n6m 424 94 Miller Miller NNP cord-347946-i6kx3n6m 424 95 , , , cord-347946-i6kx3n6m 424 96 2012 2012 CD cord-347946-i6kx3n6m 424 97 ) ) -RRB- cord-347946-i6kx3n6m 424 98 . . . cord-347946-i6kx3n6m 425 1 We -PRON- PRP cord-347946-i6kx3n6m 425 2 suggested suggest VBD cord-347946-i6kx3n6m 425 3 that that IN cord-347946-i6kx3n6m 425 4 sickness sickness NN cord-347946-i6kx3n6m 425 5 behavior behavior NN cord-347946-i6kx3n6m 425 6 - - : cord-347946-i6kx3n6m 425 7 while while NN cord-347946-i6kx3n6m 425 8 of of IN cord-347946-i6kx3n6m 425 9 benefit benefit NN cord-347946-i6kx3n6m 425 10 for for IN cord-347946-i6kx3n6m 425 11 surviving survive VBG cord-347946-i6kx3n6m 425 12 infectioncarries infectioncarrie NNS cord-347946-i6kx3n6m 425 13 its -PRON- PRP$ cord-347946-i6kx3n6m 425 14 own own JJ cord-347946-i6kx3n6m 425 15 survival survival NN cord-347946-i6kx3n6m 425 16 and and CC cord-347946-i6kx3n6m 425 17 reproduction reproduction NN cord-347946-i6kx3n6m 425 18 costs cost NNS cord-347946-i6kx3n6m 425 19 as as IN cord-347946-i6kx3n6m 425 20 a a DT cord-347946-i6kx3n6m 425 21 result result NN cord-347946-i6kx3n6m 425 22 of of IN cord-347946-i6kx3n6m 425 23 increased increase VBN cord-347946-i6kx3n6m 425 24 risk risk NN cord-347946-i6kx3n6m 425 25 for for IN cord-347946-i6kx3n6m 425 26 predation predation NN cord-347946-i6kx3n6m 425 27 and and CC cord-347946-i6kx3n6m 425 28 reduced reduce VBN cord-347946-i6kx3n6m 425 29 ability ability NN cord-347946-i6kx3n6m 425 30 to to TO cord-347946-i6kx3n6m 425 31 care care VB cord-347946-i6kx3n6m 425 32 for for IN cord-347946-i6kx3n6m 425 33 one one NN cord-347946-i6kx3n6m 425 34 's 's POS cord-347946-i6kx3n6m 425 35 young young JJ cord-347946-i6kx3n6m 425 36 , , , cord-347946-i6kx3n6m 425 37 as as RB cord-347946-i6kx3n6m 425 38 well well RB cord-347946-i6kx3n6m 425 39 as as IN cord-347946-i6kx3n6m 425 40 potential potential JJ cord-347946-i6kx3n6m 425 41 loss loss NN cord-347946-i6kx3n6m 425 42 of of IN cord-347946-i6kx3n6m 425 43 status status NN cord-347946-i6kx3n6m 425 44 in in IN cord-347946-i6kx3n6m 425 45 a a DT cord-347946-i6kx3n6m 425 46 social social JJ cord-347946-i6kx3n6m 425 47 species specie NNS cord-347946-i6kx3n6m 425 48 and/or and/or CC cord-347946-i6kx3n6m 425 49 loss loss NN cord-347946-i6kx3n6m 425 50 of of IN cord-347946-i6kx3n6m 425 51 breeding breed VBG cord-347946-i6kx3n6m 425 52 territory territory NN cord-347946-i6kx3n6m 425 53 ( ( -LRB- cord-347946-i6kx3n6m 425 54 Miller Miller NNP cord-347946-i6kx3n6m 425 55 and and CC cord-347946-i6kx3n6m 425 56 Cohen Cohen NNP cord-347946-i6kx3n6m 425 57 , , , cord-347946-i6kx3n6m 425 58 2005 2005 CD cord-347946-i6kx3n6m 425 59 ) ) -RRB- cord-347946-i6kx3n6m 425 60 , , , cord-347946-i6kx3n6m 425 61 all all DT cord-347946-i6kx3n6m 425 62 of of IN cord-347946-i6kx3n6m 425 63 which which WDT cord-347946-i6kx3n6m 425 64 were be VBD cord-347946-i6kx3n6m 425 65 relevant relevant JJ cord-347946-i6kx3n6m 425 66 to to IN cord-347946-i6kx3n6m 425 67 humans human NNS cord-347946-i6kx3n6m 425 68 in in IN cord-347946-i6kx3n6m 425 69 the the DT cord-347946-i6kx3n6m 425 70 EEA EEA NNP cord-347946-i6kx3n6m 425 71 . . . cord-347946-i6kx3n6m 426 1 Given give VBN cord-347946-i6kx3n6m 426 2 these these DT cord-347946-i6kx3n6m 426 3 competing compete VBG cord-347946-i6kx3n6m 426 4 challenges challenge NNS cord-347946-i6kx3n6m 426 5 to to IN cord-347946-i6kx3n6m 426 6 survival survival NN cord-347946-i6kx3n6m 426 7 and and CC cord-347946-i6kx3n6m 426 8 reproduction reproduction NN cord-347946-i6kx3n6m 426 9 , , , cord-347946-i6kx3n6m 426 10 evolutionary evolutionary JJ cord-347946-i6kx3n6m 426 11 logic logic NN cord-347946-i6kx3n6m 426 12 may may MD cord-347946-i6kx3n6m 426 13 have have VB cord-347946-i6kx3n6m 426 14 dictated dictate VBN cord-347946-i6kx3n6m 426 15 that that IN cord-347946-i6kx3n6m 426 16 inflammatory inflammatory JJ cord-347946-i6kx3n6m 426 17 processes process NNS cord-347946-i6kx3n6m 426 18 - - : cord-347946-i6kx3n6m 426 19 especially especially RB cord-347946-i6kx3n6m 426 20 when when WRB cord-347946-i6kx3n6m 426 21 chronic chronic NN cord-347946-i6kx3n6m 426 22 - - : cord-347946-i6kx3n6m 426 23 might may MD cord-347946-i6kx3n6m 426 24 have have VB cord-347946-i6kx3n6m 426 25 promoted promote VBN cord-347946-i6kx3n6m 426 26 hypervigilant hypervigilant JJ cord-347946-i6kx3n6m 426 27 behavior behavior NN cord-347946-i6kx3n6m 426 28 , , , cord-347946-i6kx3n6m 426 29 which which WDT cord-347946-i6kx3n6m 426 30 , , , cord-347946-i6kx3n6m 426 31 while while IN cord-347946-i6kx3n6m 426 32 shunting shunt VBG cord-347946-i6kx3n6m 426 33 energy energy NN cord-347946-i6kx3n6m 426 34 away away RB cord-347946-i6kx3n6m 426 35 from from IN cord-347946-i6kx3n6m 426 36 fighting fight VBG cord-347946-i6kx3n6m 426 37 infection infection NN cord-347946-i6kx3n6m 426 38 , , , cord-347946-i6kx3n6m 426 39 would would MD cord-347946-i6kx3n6m 426 40 nonetheless nonetheless RB cord-347946-i6kx3n6m 426 41 have have VB cord-347946-i6kx3n6m 426 42 served serve VBN cord-347946-i6kx3n6m 426 43 adaptive adaptive JJ cord-347946-i6kx3n6m 426 44 purposes purpose NNS cord-347946-i6kx3n6m 426 45 by by IN cord-347946-i6kx3n6m 426 46 protecting protect VBG cord-347946-i6kx3n6m 426 47 against against IN cord-347946-i6kx3n6m 426 48 environmental environmental JJ cord-347946-i6kx3n6m 426 49 dangers danger NNS cord-347946-i6kx3n6m 426 50 engendered engender VBN cord-347946-i6kx3n6m 426 51 by by IN cord-347946-i6kx3n6m 426 52 sickness sickness NN cord-347946-i6kx3n6m 426 53 . . . cord-347946-i6kx3n6m 427 1 Given give VBN cord-347946-i6kx3n6m 427 2 that that DT cord-347946-i6kx3n6m 427 3 human human JJ cord-347946-i6kx3n6m 427 4 females female NNS cord-347946-i6kx3n6m 427 5 and and CC cord-347946-i6kx3n6m 427 6 youth youth NN cord-347946-i6kx3n6m 427 7 likely likely RB cord-347946-i6kx3n6m 427 8 received receive VBD cord-347946-i6kx3n6m 427 9 more more JJR cord-347946-i6kx3n6m 427 10 protection protection NN cord-347946-i6kx3n6m 427 11 in in IN cord-347946-i6kx3n6m 427 12 the the DT cord-347946-i6kx3n6m 427 13 EEA EEA NNP cord-347946-i6kx3n6m 427 14 than than IN cord-347946-i6kx3n6m 427 15 did do VBD cord-347946-i6kx3n6m 427 16 adult adult NN cord-347946-i6kx3n6m 427 17 males male NNS cord-347946-i6kx3n6m 427 18 ( ( -LRB- cord-347946-i6kx3n6m 427 19 who who WP cord-347946-i6kx3n6m 427 20 therefore therefore RB cord-347946-i6kx3n6m 427 21 on on IN cord-347946-i6kx3n6m 427 22 average average JJ cord-347946-i6kx3n6m 427 23 would would MD cord-347946-i6kx3n6m 427 24 have have VB cord-347946-i6kx3n6m 427 25 more more JJR cord-347946-i6kx3n6m 427 26 to to TO cord-347946-i6kx3n6m 427 27 lose lose VB cord-347946-i6kx3n6m 427 28 from from IN cord-347946-i6kx3n6m 427 29 sickness sickness NN cord-347946-i6kx3n6m 427 30 behavior behavior NN cord-347946-i6kx3n6m 427 31 ) ) -RRB- cord-347946-i6kx3n6m 427 32 , , , cord-347946-i6kx3n6m 427 33 a a DT cord-347946-i6kx3n6m 427 34 clear clear JJ cord-347946-i6kx3n6m 427 35 prediction prediction NN cord-347946-i6kx3n6m 427 36 from from IN cord-347946-i6kx3n6m 427 37 PATHOS PATHOS NNP cord-347946-i6kx3n6m 427 38 - - HYPH cord-347946-i6kx3n6m 427 39 D D NNP cord-347946-i6kx3n6m 427 40 is be VBZ cord-347946-i6kx3n6m 427 41 that that IN cord-347946-i6kx3n6m 427 42 males male NNS cord-347946-i6kx3n6m 427 43 should should MD cord-347946-i6kx3n6m 427 44 respond respond VB cord-347946-i6kx3n6m 427 45 to to IN cord-347946-i6kx3n6m 427 46 immune immune JJ cord-347946-i6kx3n6m 427 47 challenges challenge NNS cord-347946-i6kx3n6m 427 48 / / SYM cord-347946-i6kx3n6m 427 49 inflammatory inflammatory JJ cord-347946-i6kx3n6m 427 50 activation activation NN cord-347946-i6kx3n6m 427 51 with with IN cord-347946-i6kx3n6m 427 52 an an DT cord-347946-i6kx3n6m 427 53 increased increase VBN cord-347946-i6kx3n6m 427 54 ratio ratio NN cord-347946-i6kx3n6m 427 55 of of IN cord-347946-i6kx3n6m 427 56 hypervigilant hypervigilant JJ cord-347946-i6kx3n6m 427 57 to to IN cord-347946-i6kx3n6m 427 58 conservationwithdrawal conservationwithdrawal JJ cord-347946-i6kx3n6m 427 59 symptoms symptom NNS cord-347946-i6kx3n6m 427 60 , , , cord-347946-i6kx3n6m 427 61 as as RB cord-347946-i6kx3n6m 427 62 well well RB cord-347946-i6kx3n6m 427 63 as as IN cord-347946-i6kx3n6m 427 64 an an DT cord-347946-i6kx3n6m 427 65 increase increase NN cord-347946-i6kx3n6m 427 66 in in IN cord-347946-i6kx3n6m 427 67 cytokine cytokine JJ cord-347946-i6kx3n6m 427 68 effects effect NNS cord-347946-i6kx3n6m 427 69 on on IN cord-347946-i6kx3n6m 427 70 brain brain NN cord-347946-i6kx3n6m 427 71 areas area NNS cord-347946-i6kx3n6m 427 72 such such JJ cord-347946-i6kx3n6m 427 73 as as IN cord-347946-i6kx3n6m 427 74 the the DT cord-347946-i6kx3n6m 427 75 dorsal dorsal JJ cord-347946-i6kx3n6m 427 76 anterior anterior NNP cord-347946-i6kx3n6m 427 77 cingulate cingulate NNP cord-347946-i6kx3n6m 427 78 that that WDT cord-347946-i6kx3n6m 427 79 subserve subserve NNP cord-347946-i6kx3n6m 427 80 hypervigilance hypervigilance NN cord-347946-i6kx3n6m 427 81 when when WRB cord-347946-i6kx3n6m 427 82 compared compare VBN cord-347946-i6kx3n6m 427 83 with with IN cord-347946-i6kx3n6m 427 84 cytokine cytokine JJ cord-347946-i6kx3n6m 427 85 effects effect NNS cord-347946-i6kx3n6m 427 86 on on IN cord-347946-i6kx3n6m 427 87 areas area NNS cord-347946-i6kx3n6m 427 88 such such JJ cord-347946-i6kx3n6m 427 89 as as IN cord-347946-i6kx3n6m 427 90 the the DT cord-347946-i6kx3n6m 427 91 ventral ventral JJ cord-347946-i6kx3n6m 427 92 striatum striatum NN cord-347946-i6kx3n6m 427 93 , , , cord-347946-i6kx3n6m 427 94 which which WDT cord-347946-i6kx3n6m 427 95 have have VBP cord-347946-i6kx3n6m 427 96 been be VBN cord-347946-i6kx3n6m 427 97 linked link VBN cord-347946-i6kx3n6m 427 98 to to IN cord-347946-i6kx3n6m 427 99 inflammatory inflammatory JJ cord-347946-i6kx3n6m 427 100 effects effect NNS cord-347946-i6kx3n6m 427 101 on on IN cord-347946-i6kx3n6m 427 102 anhedonia anhedonia NN cord-347946-i6kx3n6m 428 1 ( ( -LRB- cord-347946-i6kx3n6m 428 2 Felger Felger NNP cord-347946-i6kx3n6m 428 3 et et NNP cord-347946-i6kx3n6m 428 4 al al NNP cord-347946-i6kx3n6m 428 5 , , , cord-347946-i6kx3n6m 428 6 2015 2015 CD cord-347946-i6kx3n6m 428 7 ) ) -RRB- cord-347946-i6kx3n6m 428 8 , , , cord-347946-i6kx3n6m 428 9 which which WDT cord-347946-i6kx3n6m 428 10 would would MD cord-347946-i6kx3n6m 428 11 be be VB cord-347946-i6kx3n6m 428 12 expected expect VBN cord-347946-i6kx3n6m 428 13 to to TO cord-347946-i6kx3n6m 428 14 promote promote VB cord-347946-i6kx3n6m 428 15 social social JJ cord-347946-i6kx3n6m 428 16 withdrawal withdrawal NN cord-347946-i6kx3n6m 428 17 . . . cord-347946-i6kx3n6m 429 1 Available available JJ cord-347946-i6kx3n6m 429 2 data datum NNS cord-347946-i6kx3n6m 429 3 provide provide VBP cord-347946-i6kx3n6m 429 4 mixed mixed JJ cord-347946-i6kx3n6m 429 5 support support NN cord-347946-i6kx3n6m 429 6 for for IN cord-347946-i6kx3n6m 429 7 this this DT cord-347946-i6kx3n6m 429 8 hypothesis hypothesis NN cord-347946-i6kx3n6m 429 9 . . . cord-347946-i6kx3n6m 430 1 On on IN cord-347946-i6kx3n6m 430 2 the the DT cord-347946-i6kx3n6m 430 3 one one CD cord-347946-i6kx3n6m 430 4 hand hand NN cord-347946-i6kx3n6m 430 5 . . . cord-347946-i6kx3n6m 431 1 a a DT cord-347946-i6kx3n6m 431 2 recent recent JJ cord-347946-i6kx3n6m 431 3 study study NN cord-347946-i6kx3n6m 431 4 found find VBD cord-347946-i6kx3n6m 431 5 no no DT cord-347946-i6kx3n6m 431 6 difference difference NN cord-347946-i6kx3n6m 431 7 between between IN cord-347946-i6kx3n6m 431 8 males male NNS cord-347946-i6kx3n6m 431 9 and and CC cord-347946-i6kx3n6m 431 10 females female NNS cord-347946-i6kx3n6m 431 11 in in IN cord-347946-i6kx3n6m 431 12 the the DT cord-347946-i6kx3n6m 431 13 severity severity NN cord-347946-i6kx3n6m 431 14 of of IN cord-347946-i6kx3n6m 431 15 anxiety anxiety NN cord-347946-i6kx3n6m 431 16 symptoms symptom NNS cord-347946-i6kx3n6m 431 17 induced induce VBN cord-347946-i6kx3n6m 431 18 by by IN cord-347946-i6kx3n6m 431 19 low low JJ cord-347946-i6kx3n6m 431 20 - - HYPH cord-347946-i6kx3n6m 431 21 dose dose NN cord-347946-i6kx3n6m 431 22 endotoxin endotoxin NN cord-347946-i6kx3n6m 431 23 ( ( -LRB- cord-347946-i6kx3n6m 431 24 Engler Engler NNP cord-347946-i6kx3n6m 431 25 et et NNP cord-347946-i6kx3n6m 431 26 al al NNP cord-347946-i6kx3n6m 431 27 , , , cord-347946-i6kx3n6m 431 28 2016 2016 CD cord-347946-i6kx3n6m 431 29 ) ) -RRB- cord-347946-i6kx3n6m 431 30 . . . cord-347946-i6kx3n6m 432 1 On on IN cord-347946-i6kx3n6m 432 2 the the DT cord-347946-i6kx3n6m 432 3 other other JJ cord-347946-i6kx3n6m 432 4 hand hand NN cord-347946-i6kx3n6m 432 5 , , , cord-347946-i6kx3n6m 432 6 a a DT cord-347946-i6kx3n6m 432 7 recent recent JJ cord-347946-i6kx3n6m 432 8 large large JJ cord-347946-i6kx3n6m 432 9 cohort cohort NN cord-347946-i6kx3n6m 432 10 study study NN cord-347946-i6kx3n6m 432 11 reported report VBD cord-347946-i6kx3n6m 432 12 that that IN cord-347946-i6kx3n6m 432 13 peripheral peripheral JJ cord-347946-i6kx3n6m 432 14 inflammatory inflammatory JJ cord-347946-i6kx3n6m 432 15 biomarkers biomarker NNS cord-347946-i6kx3n6m 432 16 were be VBD cord-347946-i6kx3n6m 432 17 more more RBR cord-347946-i6kx3n6m 432 18 strongly strongly RB cord-347946-i6kx3n6m 432 19 associated associate VBN cord-347946-i6kx3n6m 432 20 with with IN cord-347946-i6kx3n6m 432 21 anxiety anxiety NN cord-347946-i6kx3n6m 432 22 symptoms symptom NNS cord-347946-i6kx3n6m 432 23 and and CC cord-347946-i6kx3n6m 432 24 anxiety anxiety NN cord-347946-i6kx3n6m 432 25 disorders disorder NNS cord-347946-i6kx3n6m 432 26 in in IN cord-347946-i6kx3n6m 432 27 males male NNS cord-347946-i6kx3n6m 432 28 than than IN cord-347946-i6kx3n6m 432 29 in in IN cord-347946-i6kx3n6m 432 30 females female NNS cord-347946-i6kx3n6m 432 31 ( ( -LRB- cord-347946-i6kx3n6m 432 32 Duivis Duivis NNP cord-347946-i6kx3n6m 432 33 et et NNP cord-347946-i6kx3n6m 432 34 al al NNP cord-347946-i6kx3n6m 432 35 , , , cord-347946-i6kx3n6m 432 36 2013 2013 CD cord-347946-i6kx3n6m 432 37 . . . cord-347946-i6kx3n6m 433 1 More more RBR cord-347946-i6kx3n6m 433 2 definitive definitive JJ cord-347946-i6kx3n6m 433 3 confirmation confirmation NN cord-347946-i6kx3n6m 433 4 or or CC cord-347946-i6kx3n6m 433 5 refutation refutation NN cord-347946-i6kx3n6m 433 6 of of IN cord-347946-i6kx3n6m 433 7 the the DT cord-347946-i6kx3n6m 433 8 possibility possibility NN cord-347946-i6kx3n6m 433 9 that that WDT cord-347946-i6kx3n6m 433 10 males male NNS cord-347946-i6kx3n6m 433 11 respond respond VBP cord-347946-i6kx3n6m 433 12 to to IN cord-347946-i6kx3n6m 433 13 inflammation inflammation NN cord-347946-i6kx3n6m 433 14 with with IN cord-347946-i6kx3n6m 433 15 increased increase VBN cord-347946-i6kx3n6m 433 16 hypervigilance hypervigilance NN cord-347946-i6kx3n6m 433 17 await await VBP cord-347946-i6kx3n6m 433 18 studies study NNS cord-347946-i6kx3n6m 433 19 specifically specifically RB cord-347946-i6kx3n6m 433 20 designed design VBN cord-347946-i6kx3n6m 433 21 to to TO cord-347946-i6kx3n6m 433 22 assess assess VB cord-347946-i6kx3n6m 433 23 the the DT cord-347946-i6kx3n6m 433 24 modulating modulate VBG cord-347946-i6kx3n6m 433 25 effect effect NN cord-347946-i6kx3n6m 433 26 of of IN cord-347946-i6kx3n6m 433 27 sex sex NN cord-347946-i6kx3n6m 433 28 on on IN cord-347946-i6kx3n6m 433 29 the the DT cord-347946-i6kx3n6m 433 30 impact impact NN cord-347946-i6kx3n6m 433 31 of of IN cord-347946-i6kx3n6m 433 32 cytokines cytokine NNS cord-347946-i6kx3n6m 433 33 on on IN cord-347946-i6kx3n6m 433 34 hypervigilant hypervigilant JJ cord-347946-i6kx3n6m 433 35 - - HYPH cord-347946-i6kx3n6m 433 36 specific specific JJ cord-347946-i6kx3n6m 433 37 behaviors behavior NNS cord-347946-i6kx3n6m 433 38 and and CC cord-347946-i6kx3n6m 433 39 on on IN cord-347946-i6kx3n6m 433 40 neural neural JJ cord-347946-i6kx3n6m 433 41 pathways pathway NNS cord-347946-i6kx3n6m 433 42 known know VBN cord-347946-i6kx3n6m 433 43 to to TO cord-347946-i6kx3n6m 433 44 mediate mediate VB cord-347946-i6kx3n6m 433 45 this this DT cord-347946-i6kx3n6m 433 46 type type NN cord-347946-i6kx3n6m 433 47 of of IN cord-347946-i6kx3n6m 433 48 behavior behavior NN cord-347946-i6kx3n6m 433 49 . . . cord-347946-i6kx3n6m 434 1 Given give VBN cord-347946-i6kx3n6m 434 2 significant significant JJ cord-347946-i6kx3n6m 434 3 evidence evidence NN cord-347946-i6kx3n6m 434 4 that that IN cord-347946-i6kx3n6m 434 5 maternal maternal JJ cord-347946-i6kx3n6m 434 6 depression depression NN cord-347946-i6kx3n6m 434 7 in in IN cord-347946-i6kx3n6m 434 8 the the DT cord-347946-i6kx3n6m 434 9 postpartum postpartum NN cord-347946-i6kx3n6m 434 10 period period NN cord-347946-i6kx3n6m 434 11 is be VBZ cord-347946-i6kx3n6m 434 12 associated associate VBN cord-347946-i6kx3n6m 434 13 with with IN cord-347946-i6kx3n6m 434 14 numerous numerous JJ cord-347946-i6kx3n6m 434 15 short short JJ cord-347946-i6kx3n6m 434 16 - - HYPH cord-347946-i6kx3n6m 434 17 and and CC cord-347946-i6kx3n6m 434 18 long long JJ cord-347946-i6kx3n6m 434 19 - - HYPH cord-347946-i6kx3n6m 434 20 term term NN cord-347946-i6kx3n6m 434 21 adverse adverse JJ cord-347946-i6kx3n6m 434 22 consequences consequence NNS cord-347946-i6kx3n6m 434 23 for for IN cord-347946-i6kx3n6m 434 24 the the DT cord-347946-i6kx3n6m 434 25 affected affect VBN cord-347946-i6kx3n6m 434 26 offspring offspring NN cord-347946-i6kx3n6m 435 1 ( ( -LRB- cord-347946-i6kx3n6m 435 2 Ghodsian Ghodsian NNP cord-347946-i6kx3n6m 435 3 et et FW cord-347946-i6kx3n6m 435 4 al al NNP cord-347946-i6kx3n6m 435 5 , , , cord-347946-i6kx3n6m 435 6 1984 1984 CD cord-347946-i6kx3n6m 435 7 ; ; : cord-347946-i6kx3n6m 435 8 Stein Stein NNP cord-347946-i6kx3n6m 435 9 et et NNP cord-347946-i6kx3n6m 435 10 al al NNP cord-347946-i6kx3n6m 435 11 , , , cord-347946-i6kx3n6m 435 12 1991 1991 CD cord-347946-i6kx3n6m 435 13 ; ; : cord-347946-i6kx3n6m 435 14 Beardslee Beardslee NNP cord-347946-i6kx3n6m 435 15 et et NNP cord-347946-i6kx3n6m 435 16 al al NNP cord-347946-i6kx3n6m 435 17 , , , cord-347946-i6kx3n6m 435 18 1998 1998 CD cord-347946-i6kx3n6m 435 19 ; ; : cord-347946-i6kx3n6m 436 1 Beck Beck NNP cord-347946-i6kx3n6m 436 2 , , , cord-347946-i6kx3n6m 436 3 1999 1999 CD cord-347946-i6kx3n6m 436 4 ; ; : cord-347946-i6kx3n6m 436 5 Halligan Halligan NNP cord-347946-i6kx3n6m 436 6 et et NNP cord-347946-i6kx3n6m 436 7 al al NNP cord-347946-i6kx3n6m 436 8 , , , cord-347946-i6kx3n6m 436 9 2007 2007 CD cord-347946-i6kx3n6m 436 10 ; ; : cord-347946-i6kx3n6m 436 11 Kersten Kersten NNP cord-347946-i6kx3n6m 436 12 - - HYPH cord-347946-i6kx3n6m 436 13 Alvarez Alvarez NNP cord-347946-i6kx3n6m 436 14 et et NNP cord-347946-i6kx3n6m 436 15 al al NNP cord-347946-i6kx3n6m 436 16 , , , cord-347946-i6kx3n6m 436 17 2012 2012 CD cord-347946-i6kx3n6m 436 18 ) ) -RRB- cord-347946-i6kx3n6m 436 19 , , , cord-347946-i6kx3n6m 436 20 the the DT cord-347946-i6kx3n6m 436 21 question question NN cord-347946-i6kx3n6m 436 22 of of IN cord-347946-i6kx3n6m 436 23 why why WRB cord-347946-i6kx3n6m 436 24 the the DT cord-347946-i6kx3n6m 436 25 condition condition NN cord-347946-i6kx3n6m 436 26 is be VBZ cord-347946-i6kx3n6m 436 27 so so RB cord-347946-i6kx3n6m 436 28 common common JJ cord-347946-i6kx3n6m 436 29 is be VBZ cord-347946-i6kx3n6m 436 30 especially especially RB cord-347946-i6kx3n6m 436 31 pressing press VBG cord-347946-i6kx3n6m 436 32 . . . cord-347946-i6kx3n6m 437 1 As as IN cord-347946-i6kx3n6m 437 2 with with IN cord-347946-i6kx3n6m 437 3 all all DT cord-347946-i6kx3n6m 437 4 evolutionary evolutionary JJ cord-347946-i6kx3n6m 437 5 considerations consideration NNS cord-347946-i6kx3n6m 437 6 , , , cord-347946-i6kx3n6m 437 7 the the DT cord-347946-i6kx3n6m 437 8 first first JJ cord-347946-i6kx3n6m 437 9 question question NN cord-347946-i6kx3n6m 437 10 to to TO cord-347946-i6kx3n6m 437 11 consider consider VB cord-347946-i6kx3n6m 437 12 is be VBZ cord-347946-i6kx3n6m 437 13 whether whether IN cord-347946-i6kx3n6m 437 14 risk risk NN cord-347946-i6kx3n6m 437 15 genes gene NNS cord-347946-i6kx3n6m 437 16 that that WDT cord-347946-i6kx3n6m 437 17 promote promote VBP cord-347946-i6kx3n6m 437 18 postpartum postpartum NN cord-347946-i6kx3n6m 437 19 depression depression NN cord-347946-i6kx3n6m 437 20 ( ( -LRB- cord-347946-i6kx3n6m 437 21 PPD PPD NNP cord-347946-i6kx3n6m 437 22 ) ) -RRB- cord-347946-i6kx3n6m 437 23 confer confer VBP cord-347946-i6kx3n6m 437 24 an an DT cord-347946-i6kx3n6m 437 25 adaptive adaptive JJ cord-347946-i6kx3n6m 437 26 benefit benefit NN cord-347946-i6kx3n6m 437 27 , , , cord-347946-i6kx3n6m 437 28 at at IN cord-347946-i6kx3n6m 437 29 least least JJS cord-347946-i6kx3n6m 437 30 in in IN cord-347946-i6kx3n6m 437 31 part part NN cord-347946-i6kx3n6m 437 32 , , , cord-347946-i6kx3n6m 437 33 via via IN cord-347946-i6kx3n6m 437 34 benefits benefit NNS cord-347946-i6kx3n6m 437 35 resulting result VBG cord-347946-i6kx3n6m 437 36 from from IN cord-347946-i6kx3n6m 437 37 the the DT cord-347946-i6kx3n6m 437 38 condition condition NN cord-347946-i6kx3n6m 437 39 itself -PRON- PRP cord-347946-i6kx3n6m 437 40 or or CC cord-347946-i6kx3n6m 437 41 whether whether IN cord-347946-i6kx3n6m 437 42 PPD PPD NNP cord-347946-i6kx3n6m 437 43 is be VBZ cord-347946-i6kx3n6m 437 44 pleiotropically pleiotropically RB cord-347946-i6kx3n6m 437 45 linked link VBN cord-347946-i6kx3n6m 437 46 to to IN cord-347946-i6kx3n6m 437 47 non non JJ cord-347946-i6kx3n6m 437 48 - - JJ cord-347946-i6kx3n6m 437 49 related related JJ cord-347946-i6kx3n6m 437 50 effects effect NNS cord-347946-i6kx3n6m 437 51 of of IN cord-347946-i6kx3n6m 437 52 these these DT cord-347946-i6kx3n6m 437 53 genes gene NNS cord-347946-i6kx3n6m 437 54 that that WDT cord-347946-i6kx3n6m 437 55 benefitted benefit VBD cord-347946-i6kx3n6m 437 56 survival survival NN cord-347946-i6kx3n6m 437 57 and/or and/or CC cord-347946-i6kx3n6m 437 58 reproduction reproduction NN cord-347946-i6kx3n6m 437 59 across across IN cord-347946-i6kx3n6m 437 60 evolution evolution NN cord-347946-i6kx3n6m 437 61 in in IN cord-347946-i6kx3n6m 437 62 ways way NNS cord-347946-i6kx3n6m 437 63 that that WDT cord-347946-i6kx3n6m 437 64 outweighed outweigh VBD cord-347946-i6kx3n6m 437 65 the the DT cord-347946-i6kx3n6m 437 66 cost cost NN cord-347946-i6kx3n6m 437 67 of of IN cord-347946-i6kx3n6m 437 68 PPD PPD NNP cord-347946-i6kx3n6m 437 69 . . . cord-347946-i6kx3n6m 438 1 From from IN cord-347946-i6kx3n6m 438 2 a a DT cord-347946-i6kx3n6m 438 3 PATHOS pathos NN cord-347946-i6kx3n6m 438 4 - - HYPH cord-347946-i6kx3n6m 438 5 D d JJ cord-347946-i6kx3n6m 438 6 perspective perspective NN cord-347946-i6kx3n6m 438 7 , , , cord-347946-i6kx3n6m 438 8 the the DT cord-347946-i6kx3n6m 438 9 question question NN cord-347946-i6kx3n6m 438 10 might may MD cord-347946-i6kx3n6m 438 11 be be VB cord-347946-i6kx3n6m 438 12 framed frame VBN cord-347946-i6kx3n6m 438 13 by by IN cord-347946-i6kx3n6m 438 14 asking ask VBG cord-347946-i6kx3n6m 438 15 whether whether IN cord-347946-i6kx3n6m 438 16 PPD PPD NNP cord-347946-i6kx3n6m 438 17 enhanced enhance VBN cord-347946-i6kx3n6m 438 18 maternal maternal JJ cord-347946-i6kx3n6m 438 19 survival survival NN cord-347946-i6kx3n6m 438 20 and/or and/or CC cord-347946-i6kx3n6m 438 21 reproduction reproduction NN cord-347946-i6kx3n6m 438 22 via via IN cord-347946-i6kx3n6m 438 23 an an DT cord-347946-i6kx3n6m 438 24 overall overall JJ cord-347946-i6kx3n6m 438 25 net net JJ cord-347946-i6kx3n6m 438 26 benefit benefit NN cord-347946-i6kx3n6m 438 27 in in IN cord-347946-i6kx3n6m 438 28 pathogen pathogen NN cord-347946-i6kx3n6m 438 29 - - HYPH cord-347946-i6kx3n6m 438 30 host host NN cord-347946-i6kx3n6m 438 31 defense defense NN cord-347946-i6kx3n6m 438 32 . . . cord-347946-i6kx3n6m 439 1 In in IN cord-347946-i6kx3n6m 439 2 terms term NNS cord-347946-i6kx3n6m 439 3 of of IN cord-347946-i6kx3n6m 439 4 maternal maternal JJ cord-347946-i6kx3n6m 439 5 survival survival NN cord-347946-i6kx3n6m 439 6 , , , cord-347946-i6kx3n6m 439 7 PPD PPD NNP cord-347946-i6kx3n6m 439 8 would would MD cord-347946-i6kx3n6m 439 9 be be VB cord-347946-i6kx3n6m 439 10 expected expect VBN cord-347946-i6kx3n6m 439 11 to to TO cord-347946-i6kx3n6m 439 12 serve serve VB cord-347946-i6kx3n6m 439 13 the the DT cord-347946-i6kx3n6m 439 14 same same JJ cord-347946-i6kx3n6m 439 15 pathogen pathogen NN cord-347946-i6kx3n6m 439 16 defense defense NN cord-347946-i6kx3n6m 439 17 purposes purpose NNS cord-347946-i6kx3n6m 439 18 as as IN cord-347946-i6kx3n6m 439 19 MDD MDD NNP cord-347946-i6kx3n6m 439 20 in in IN cord-347946-i6kx3n6m 439 21 general general NN cord-347946-i6kx3n6m 439 22 . . . cord-347946-i6kx3n6m 440 1 However however RB cord-347946-i6kx3n6m 440 2 , , , cord-347946-i6kx3n6m 440 3 what what WP cord-347946-i6kx3n6m 440 4 about about IN cord-347946-i6kx3n6m 440 5 the the DT cord-347946-i6kx3n6m 440 6 survival survival NN cord-347946-i6kx3n6m 440 7 of of IN cord-347946-i6kx3n6m 440 8 the the DT cord-347946-i6kx3n6m 440 9 newborn newborn NN cord-347946-i6kx3n6m 440 10 , , , cord-347946-i6kx3n6m 440 11 which which WDT cord-347946-i6kx3n6m 440 12 reflects reflect VBZ cord-347946-i6kx3n6m 440 13 a a DT cord-347946-i6kx3n6m 440 14 significant significant JJ cord-347946-i6kx3n6m 440 15 investment investment NN cord-347946-i6kx3n6m 440 16 on on IN cord-347946-i6kx3n6m 440 17 the the DT cord-347946-i6kx3n6m 440 18 mother mother NN cord-347946-i6kx3n6m 440 19 's 's POS cord-347946-i6kx3n6m 440 20 part part NN cord-347946-i6kx3n6m 440 21 in in IN cord-347946-i6kx3n6m 440 22 her -PRON- PRP$ cord-347946-i6kx3n6m 440 23 long long JJ cord-347946-i6kx3n6m 440 24 - - HYPH cord-347946-i6kx3n6m 440 25 term term NN cord-347946-i6kx3n6m 440 26 reproductive reproductive JJ cord-347946-i6kx3n6m 440 27 success success NN cord-347946-i6kx3n6m 440 28 ? ? . cord-347946-i6kx3n6m 441 1 Might may MD cord-347946-i6kx3n6m 441 2 maternal maternal JJ cord-347946-i6kx3n6m 441 3 depression depression NN cord-347946-i6kx3n6m 441 4 contribute contribute VB cord-347946-i6kx3n6m 441 5 to to IN cord-347946-i6kx3n6m 441 6 the the DT cord-347946-i6kx3n6m 441 7 child child NN cord-347946-i6kx3n6m 441 8 's 's POS cord-347946-i6kx3n6m 441 9 pathogen pathogen NN cord-347946-i6kx3n6m 441 10 - - HYPH cord-347946-i6kx3n6m 441 11 host host NN cord-347946-i6kx3n6m 441 12 defense defense NN cord-347946-i6kx3n6m 441 13 prospects prospect NNS cord-347946-i6kx3n6m 441 14 ? ? . cord-347946-i6kx3n6m 442 1 An an DT cord-347946-i6kx3n6m 442 2 interesting interesting JJ cord-347946-i6kx3n6m 442 3 twist twist NN cord-347946-i6kx3n6m 442 4 on on IN cord-347946-i6kx3n6m 442 5 this this DT cord-347946-i6kx3n6m 442 6 theme theme NN cord-347946-i6kx3n6m 442 7 might may MD cord-347946-i6kx3n6m 442 8 be be VB cord-347946-i6kx3n6m 442 9 provided provide VBN cord-347946-i6kx3n6m 442 10 by by IN cord-347946-i6kx3n6m 442 11 Parental Parental NNP cord-347946-i6kx3n6m 442 12 Investment Investment NNP cord-347946-i6kx3n6m 442 13 Theory Theory NNP cord-347946-i6kx3n6m 442 14 , , , cord-347946-i6kx3n6m 442 15 which which WDT cord-347946-i6kx3n6m 442 16 postulates postulate VBZ cord-347946-i6kx3n6m 442 17 that that IN cord-347946-i6kx3n6m 442 18 parents parent NNS cord-347946-i6kx3n6m 442 19 reduce reduce VBP cord-347946-i6kx3n6m 442 20 their -PRON- PRP$ cord-347946-i6kx3n6m 442 21 care care NN cord-347946-i6kx3n6m 442 22 for for IN cord-347946-i6kx3n6m 442 23 , , , cord-347946-i6kx3n6m 442 24 and and CC cord-347946-i6kx3n6m 442 25 involvement involvement NN cord-347946-i6kx3n6m 442 26 with with IN cord-347946-i6kx3n6m 442 27 , , , cord-347946-i6kx3n6m 442 28 offspring offspring NN cord-347946-i6kx3n6m 442 29 when when WRB cord-347946-i6kx3n6m 442 30 the the DT cord-347946-i6kx3n6m 442 31 costs cost NNS cord-347946-i6kx3n6m 442 32 of of IN cord-347946-i6kx3n6m 442 33 such such JJ cord-347946-i6kx3n6m 442 34 care care NN cord-347946-i6kx3n6m 442 35 and and CC cord-347946-i6kx3n6m 442 36 involvement involvement NN cord-347946-i6kx3n6m 442 37 outweigh outweigh VBP cord-347946-i6kx3n6m 442 38 the the DT cord-347946-i6kx3n6m 442 39 benefits benefit NNS cord-347946-i6kx3n6m 442 40 ( ( -LRB- cord-347946-i6kx3n6m 442 41 Trivers Trivers NNP cord-347946-i6kx3n6m 442 42 , , , cord-347946-i6kx3n6m 442 43 1972 1972 CD cord-347946-i6kx3n6m 442 44 ) ) -RRB- cord-347946-i6kx3n6m 442 45 . . . cord-347946-i6kx3n6m 443 1 Building build VBG cord-347946-i6kx3n6m 443 2 on on IN cord-347946-i6kx3n6m 443 3 this this DT cord-347946-i6kx3n6m 443 4 theory theory NN cord-347946-i6kx3n6m 443 5 , , , cord-347946-i6kx3n6m 443 6 it -PRON- PRP cord-347946-i6kx3n6m 443 7 has have VBZ cord-347946-i6kx3n6m 443 8 been be VBN cord-347946-i6kx3n6m 443 9 argued argue VBN cord-347946-i6kx3n6m 443 10 that that IN cord-347946-i6kx3n6m 443 11 PPD PPD NNP cord-347946-i6kx3n6m 443 12 is be VBZ cord-347946-i6kx3n6m 443 13 an an DT cord-347946-i6kx3n6m 443 14 evolved evolved JJ cord-347946-i6kx3n6m 443 15 mechanism mechanism NN cord-347946-i6kx3n6m 443 16 that that WDT cord-347946-i6kx3n6m 443 17 aids aid VBZ cord-347946-i6kx3n6m 443 18 mothers mother NNS cord-347946-i6kx3n6m 443 19 in in IN cord-347946-i6kx3n6m 443 20 disengaging disengage VBG cord-347946-i6kx3n6m 443 21 from from IN cord-347946-i6kx3n6m 443 22 infants infant NNS cord-347946-i6kx3n6m 443 23 with with IN cord-347946-i6kx3n6m 443 24 a a DT cord-347946-i6kx3n6m 443 25 low low JJ cord-347946-i6kx3n6m 443 26 chance chance NN cord-347946-i6kx3n6m 443 27 of of IN cord-347946-i6kx3n6m 443 28 surviving survive VBG cord-347946-i6kx3n6m 443 29 ( ( -LRB- cord-347946-i6kx3n6m 443 30 Hagen Hagen NNP cord-347946-i6kx3n6m 443 31 , , , cord-347946-i6kx3n6m 443 32 1999 1999 CD cord-347946-i6kx3n6m 443 33 ; ; : cord-347946-i6kx3n6m 443 34 Bottino Bottino NNP cord-347946-i6kx3n6m 443 35 et et NNP cord-347946-i6kx3n6m 443 36 al al NNP cord-347946-i6kx3n6m 443 37 , , , cord-347946-i6kx3n6m 443 38 2012 2012 CD cord-347946-i6kx3n6m 443 39 ) ) -RRB- cord-347946-i6kx3n6m 443 40 . . . cord-347946-i6kx3n6m 444 1 Because because IN cord-347946-i6kx3n6m 444 2 infection infection NN cord-347946-i6kx3n6m 444 3 was be VBD cord-347946-i6kx3n6m 444 4 the the DT cord-347946-i6kx3n6m 444 5 primary primary JJ cord-347946-i6kx3n6m 444 6 cause cause NN cord-347946-i6kx3n6m 444 7 of of IN cord-347946-i6kx3n6m 444 8 infant infant NN cord-347946-i6kx3n6m 444 9 mortality mortality NN cord-347946-i6kx3n6m 444 10 across across IN cord-347946-i6kx3n6m 444 11 human human JJ cord-347946-i6kx3n6m 444 12 evolution evolution NN cord-347946-i6kx3n6m 444 13 , , , cord-347946-i6kx3n6m 444 14 one one PRP cord-347946-i6kx3n6m 444 15 might may MD cord-347946-i6kx3n6m 444 16 predict predict VB cord-347946-i6kx3n6m 444 17 that that IN cord-347946-i6kx3n6m 444 18 PPD PPD NNP cord-347946-i6kx3n6m 444 19 would would MD cord-347946-i6kx3n6m 444 20 be be VB cord-347946-i6kx3n6m 444 21 more more RBR cord-347946-i6kx3n6m 444 22 likely likely JJ cord-347946-i6kx3n6m 444 23 to to TO cord-347946-i6kx3n6m 444 24 develop develop VB cord-347946-i6kx3n6m 444 25 in in IN cord-347946-i6kx3n6m 444 26 response response NN cord-347946-i6kx3n6m 444 27 to to IN cord-347946-i6kx3n6m 444 28 giving give VBG cord-347946-i6kx3n6m 444 29 birth birth NN cord-347946-i6kx3n6m 444 30 to to IN cord-347946-i6kx3n6m 444 31 an an DT cord-347946-i6kx3n6m 444 32 unhealthy unhealthy JJ cord-347946-i6kx3n6m 444 33 infant infant NN cord-347946-i6kx3n6m 444 34 , , , cord-347946-i6kx3n6m 444 35 and and CC cord-347946-i6kx3n6m 444 36 data datum NNS cord-347946-i6kx3n6m 444 37 from from IN cord-347946-i6kx3n6m 444 38 hunter hunter NN cord-347946-i6kx3n6m 444 39 - - HYPH cord-347946-i6kx3n6m 444 40 horticulturalists horticulturalist NNS cord-347946-i6kx3n6m 444 41 in in IN cord-347946-i6kx3n6m 444 42 the the DT cord-347946-i6kx3n6m 444 43 Amazon Amazon NNP cord-347946-i6kx3n6m 444 44 basin basin NN cord-347946-i6kx3n6m 444 45 are be VBP cord-347946-i6kx3n6m 444 46 consistent consistent JJ cord-347946-i6kx3n6m 444 47 with with IN cord-347946-i6kx3n6m 444 48 this this DT cord-347946-i6kx3n6m 444 49 prediction prediction NN cord-347946-i6kx3n6m 444 50 ( ( -LRB- cord-347946-i6kx3n6m 444 51 Hagen Hagen NNP cord-347946-i6kx3n6m 444 52 and and CC cord-347946-i6kx3n6m 444 53 Barrett Barrett NNP cord-347946-i6kx3n6m 444 54 , , , cord-347946-i6kx3n6m 444 55 2007 2007 CD cord-347946-i6kx3n6m 444 56 ) ) -RRB- cord-347946-i6kx3n6m 444 57 . . . cord-347946-i6kx3n6m 445 1 Under under IN cord-347946-i6kx3n6m 445 2 this this DT cord-347946-i6kx3n6m 445 3 scenario scenario NN cord-347946-i6kx3n6m 445 4 , , , cord-347946-i6kx3n6m 445 5 PPD PPD NNP cord-347946-i6kx3n6m 445 6 , , , cord-347946-i6kx3n6m 445 7 rather rather RB cord-347946-i6kx3n6m 445 8 than than IN cord-347946-i6kx3n6m 445 9 helping help VBG cord-347946-i6kx3n6m 445 10 the the DT cord-347946-i6kx3n6m 445 11 infant infant NN cord-347946-i6kx3n6m 445 12 survive survive VB cord-347946-i6kx3n6m 445 13 pathogen pathogen NN cord-347946-i6kx3n6m 445 14 challenge challenge NN cord-347946-i6kx3n6m 445 15 , , , cord-347946-i6kx3n6m 445 16 would would MD cord-347946-i6kx3n6m 445 17 actually actually RB cord-347946-i6kx3n6m 445 18 serve serve VB cord-347946-i6kx3n6m 445 19 as as IN cord-347946-i6kx3n6m 445 20 a a DT cord-347946-i6kx3n6m 445 21 ' ' `` cord-347946-i6kx3n6m 445 22 warning warning NN cord-347946-i6kx3n6m 445 23 signal signal NN cord-347946-i6kx3n6m 445 24 ' ' '' cord-347946-i6kx3n6m 445 25 to to IN cord-347946-i6kx3n6m 445 26 the the DT cord-347946-i6kx3n6m 445 27 mother mother NN cord-347946-i6kx3n6m 445 28 that that IN cord-347946-i6kx3n6m 445 29 the the DT cord-347946-i6kx3n6m 445 30 infant infant NN cord-347946-i6kx3n6m 445 31 's 's POS cord-347946-i6kx3n6m 445 32 likelihood likelihood NN cord-347946-i6kx3n6m 445 33 of of IN cord-347946-i6kx3n6m 445 34 surviving survive VBG cord-347946-i6kx3n6m 445 35 postnatal postnatal JJ cord-347946-i6kx3n6m 445 36 pathogen pathogen NN cord-347946-i6kx3n6m 445 37 exposure exposure NN cord-347946-i6kx3n6m 445 38 was be VBD cord-347946-i6kx3n6m 445 39 not not RB cord-347946-i6kx3n6m 445 40 high high JJ cord-347946-i6kx3n6m 445 41 enough enough RB cord-347946-i6kx3n6m 445 42 to to TO cord-347946-i6kx3n6m 445 43 warrant warrant VB cord-347946-i6kx3n6m 445 44 significant significant JJ cord-347946-i6kx3n6m 445 45 resource resource NN cord-347946-i6kx3n6m 445 46 investments investment NNS cord-347946-i6kx3n6m 445 47 . . . cord-347946-i6kx3n6m 446 1 Although although IN cord-347946-i6kx3n6m 446 2 consistent consistent JJ cord-347946-i6kx3n6m 446 3 with with IN cord-347946-i6kx3n6m 446 4 a a DT cord-347946-i6kx3n6m 446 5 PATHOS pathos NN cord-347946-i6kx3n6m 446 6 - - HYPH cord-347946-i6kx3n6m 446 7 D d JJ cord-347946-i6kx3n6m 446 8 focus focus NN cord-347946-i6kx3n6m 446 9 on on IN cord-347946-i6kx3n6m 446 10 the the DT cord-347946-i6kx3n6m 446 11 primacy primacy NN cord-347946-i6kx3n6m 446 12 of of IN cord-347946-i6kx3n6m 446 13 pathogen pathogen NN cord-347946-i6kx3n6m 446 14 - - HYPH cord-347946-i6kx3n6m 446 15 host host NN cord-347946-i6kx3n6m 446 16 interactions interaction NNS cord-347946-i6kx3n6m 446 17 in in IN cord-347946-i6kx3n6m 446 18 selecting select VBG cord-347946-i6kx3n6m 446 19 for for IN cord-347946-i6kx3n6m 446 20 depression depression NN cord-347946-i6kx3n6m 446 21 - - HYPH cord-347946-i6kx3n6m 446 22 promoting promote VBG cord-347946-i6kx3n6m 446 23 genetic genetic JJ cord-347946-i6kx3n6m 446 24 variants variant NNS cord-347946-i6kx3n6m 446 25 , , , cord-347946-i6kx3n6m 446 26 the the DT cord-347946-i6kx3n6m 446 27 notion notion NN cord-347946-i6kx3n6m 446 28 that that IN cord-347946-i6kx3n6m 446 29 PPD PPD NNP cord-347946-i6kx3n6m 446 30 functions function NNS cord-347946-i6kx3n6m 446 31 as as IN cord-347946-i6kx3n6m 446 32 a a DT cord-347946-i6kx3n6m 446 33 type type NN cord-347946-i6kx3n6m 446 34 of of IN cord-347946-i6kx3n6m 446 35 immunological immunological JJ cord-347946-i6kx3n6m 446 36 abandonment abandonment NN cord-347946-i6kx3n6m 446 37 strategy strategy NN cord-347946-i6kx3n6m 446 38 goes go VBZ cord-347946-i6kx3n6m 446 39 against against IN cord-347946-i6kx3n6m 446 40 the the DT cord-347946-i6kx3n6m 446 41 general general JJ cord-347946-i6kx3n6m 446 42 tenor tenor NN cord-347946-i6kx3n6m 446 43 of of IN cord-347946-i6kx3n6m 446 44 the the DT cord-347946-i6kx3n6m 446 45 theory theory NN cord-347946-i6kx3n6m 446 46 , , , cord-347946-i6kx3n6m 446 47 which which WDT cord-347946-i6kx3n6m 446 48 sees see VBZ cord-347946-i6kx3n6m 446 49 the the DT cord-347946-i6kx3n6m 446 50 link link NN cord-347946-i6kx3n6m 446 51 between between IN cord-347946-i6kx3n6m 446 52 depression depression NN cord-347946-i6kx3n6m 446 53 and and CC cord-347946-i6kx3n6m 446 54 immunity immunity NN cord-347946-i6kx3n6m 446 55 as as IN cord-347946-i6kx3n6m 446 56 providing provide VBG cord-347946-i6kx3n6m 446 57 overall overall JJ cord-347946-i6kx3n6m 446 58 advantages advantage NNS cord-347946-i6kx3n6m 446 59 in in IN cord-347946-i6kx3n6m 446 60 the the DT cord-347946-i6kx3n6m 446 61 face face NN cord-347946-i6kx3n6m 446 62 of of IN cord-347946-i6kx3n6m 446 63 infectious infectious JJ cord-347946-i6kx3n6m 446 64 morbidity morbidity NN cord-347946-i6kx3n6m 446 65 and and CC cord-347946-i6kx3n6m 446 66 mortality mortality NN cord-347946-i6kx3n6m 446 67 , , , cord-347946-i6kx3n6m 446 68 whatever whatever WDT cord-347946-i6kx3n6m 446 69 their -PRON- PRP$ cord-347946-i6kx3n6m 446 70 costs cost NNS cord-347946-i6kx3n6m 446 71 in in IN cord-347946-i6kx3n6m 446 72 other other JJ cord-347946-i6kx3n6m 446 73 domains domain NNS cord-347946-i6kx3n6m 446 74 . . . cord-347946-i6kx3n6m 447 1 Whether whether IN cord-347946-i6kx3n6m 447 2 PPD PPD NNP cord-347946-i6kx3n6m 447 3 is be VBZ cord-347946-i6kx3n6m 447 4 associated associate VBN cord-347946-i6kx3n6m 447 5 with with IN cord-347946-i6kx3n6m 447 6 behavioral behavioral JJ cord-347946-i6kx3n6m 447 7 or or CC cord-347946-i6kx3n6m 447 8 immune immune JJ cord-347946-i6kx3n6m 447 9 changes change NNS cord-347946-i6kx3n6m 447 10 that that WDT cord-347946-i6kx3n6m 447 11 might may MD cord-347946-i6kx3n6m 447 12 actually actually RB cord-347946-i6kx3n6m 447 13 help help VB cord-347946-i6kx3n6m 447 14 infant infant NN cord-347946-i6kx3n6m 447 15 survival survival NN cord-347946-i6kx3n6m 447 16 - - , cord-347946-i6kx3n6m 447 17 especially especially RB cord-347946-i6kx3n6m 447 18 in in IN cord-347946-i6kx3n6m 447 19 conditions condition NNS cord-347946-i6kx3n6m 447 20 such such JJ cord-347946-i6kx3n6m 447 21 as as IN cord-347946-i6kx3n6m 447 22 high high JJ cord-347946-i6kx3n6m 447 23 environmental environmental JJ cord-347946-i6kx3n6m 447 24 pathogen pathogen NN cord-347946-i6kx3n6m 447 25 exposure exposure NN cord-347946-i6kx3n6m 447 26 , , , cord-347946-i6kx3n6m 447 27 reduced reduce VBN cord-347946-i6kx3n6m 447 28 metabolic metabolic JJ cord-347946-i6kx3n6m 447 29 resources resource NNS cord-347946-i6kx3n6m 447 30 or or CC cord-347946-i6kx3n6m 447 31 increased increase VBN cord-347946-i6kx3n6m 447 32 infant infant NN cord-347946-i6kx3n6m 447 33 vulnerability vulnerability NN cord-347946-i6kx3n6m 447 34 to to IN cord-347946-i6kx3n6m 447 35 infection infection NN cord-347946-i6kx3n6m 447 36 - - : cord-347946-i6kx3n6m 447 37 is be VBZ cord-347946-i6kx3n6m 447 38 a a DT cord-347946-i6kx3n6m 447 39 question question NN cord-347946-i6kx3n6m 447 40 that that IN cord-347946-i6kx3n6m 447 41 to to IN cord-347946-i6kx3n6m 447 42 our -PRON- PRP$ cord-347946-i6kx3n6m 447 43 knowledge knowledge NN cord-347946-i6kx3n6m 447 44 has have VBZ cord-347946-i6kx3n6m 447 45 never never RB cord-347946-i6kx3n6m 447 46 been be VBN cord-347946-i6kx3n6m 447 47 examined examine VBN cord-347946-i6kx3n6m 447 48 . . . cord-347946-i6kx3n6m 448 1 Certainly certainly RB cord-347946-i6kx3n6m 448 2 it -PRON- PRP cord-347946-i6kx3n6m 448 3 is be VBZ cord-347946-i6kx3n6m 448 4 possible possible JJ cord-347946-i6kx3n6m 448 5 that that IN cord-347946-i6kx3n6m 448 6 PPD ppd NN cord-347946-i6kx3n6m 448 7 - - HYPH cord-347946-i6kx3n6m 448 8 induced induce VBN cord-347946-i6kx3n6m 448 9 maternal maternal JJ cord-347946-i6kx3n6m 448 10 withdrawal withdrawal NN cord-347946-i6kx3n6m 448 11 might may MD cord-347946-i6kx3n6m 448 12 have have VB cord-347946-i6kx3n6m 448 13 decreased decrease VBN cord-347946-i6kx3n6m 448 14 the the DT cord-347946-i6kx3n6m 448 15 risk risk NN cord-347946-i6kx3n6m 448 16 of of IN cord-347946-i6kx3n6m 448 17 infant infant NN cord-347946-i6kx3n6m 448 18 infection infection NN cord-347946-i6kx3n6m 448 19 in in IN cord-347946-i6kx3n6m 448 20 circumstances circumstance NNS cord-347946-i6kx3n6m 448 21 when when WRB cord-347946-i6kx3n6m 448 22 the the DT cord-347946-i6kx3n6m 448 23 maternal maternal JJ cord-347946-i6kx3n6m 448 24 depression depression NN cord-347946-i6kx3n6m 448 25 resulted result VBD cord-347946-i6kx3n6m 448 26 from from IN cord-347946-i6kx3n6m 448 27 pathogen pathogen NN cord-347946-i6kx3n6m 448 28 - - HYPH cord-347946-i6kx3n6m 448 29 induced induce VBN cord-347946-i6kx3n6m 448 30 cytokine cytokine NN cord-347946-i6kx3n6m 448 31 activation activation NN cord-347946-i6kx3n6m 448 32 . . . cord-347946-i6kx3n6m 449 1 It -PRON- PRP cord-347946-i6kx3n6m 449 2 is be VBZ cord-347946-i6kx3n6m 449 3 also also RB cord-347946-i6kx3n6m 449 4 intriguing intriguing JJ cord-347946-i6kx3n6m 449 5 to to TO cord-347946-i6kx3n6m 449 6 speculate speculate VB cord-347946-i6kx3n6m 449 7 that that IN cord-347946-i6kx3n6m 449 8 PPD PPD NNP cord-347946-i6kx3n6m 449 9 might may MD cord-347946-i6kx3n6m 449 10 influence influence VB cord-347946-i6kx3n6m 449 11 the the DT cord-347946-i6kx3n6m 449 12 composition composition NN cord-347946-i6kx3n6m 449 13 of of IN cord-347946-i6kx3n6m 449 14 breast breast NN cord-347946-i6kx3n6m 449 15 milk milk NN cord-347946-i6kx3n6m 449 16 in in IN cord-347946-i6kx3n6m 449 17 ways way NNS cord-347946-i6kx3n6m 449 18 that that WDT cord-347946-i6kx3n6m 449 19 might may MD cord-347946-i6kx3n6m 449 20 aid aid VB cord-347946-i6kx3n6m 449 21 nursing nursing NN cord-347946-i6kx3n6m 449 22 infants infant NNS cord-347946-i6kx3n6m 449 23 in in IN cord-347946-i6kx3n6m 449 24 avoiding avoid VBG cord-347946-i6kx3n6m 449 25 or or CC cord-347946-i6kx3n6m 449 26 surviving survive VBG cord-347946-i6kx3n6m 449 27 infection infection NN cord-347946-i6kx3n6m 449 28 . . . cord-347946-i6kx3n6m 450 1 Intriguingly intriguingly RB cord-347946-i6kx3n6m 450 2 , , , cord-347946-i6kx3n6m 450 3 a a DT cord-347946-i6kx3n6m 450 4 Japanese japanese JJ cord-347946-i6kx3n6m 450 5 study study NN cord-347946-i6kx3n6m 450 6 found find VBD cord-347946-i6kx3n6m 450 7 PPD PPD NNP cord-347946-i6kx3n6m 450 8 to to TO cord-347946-i6kx3n6m 450 9 be be VB cord-347946-i6kx3n6m 450 10 associated associate VBN cord-347946-i6kx3n6m 450 11 with with IN cord-347946-i6kx3n6m 450 12 increased increase VBN cord-347946-i6kx3n6m 450 13 breast breast NN cord-347946-i6kx3n6m 450 14 milk milk NN cord-347946-i6kx3n6m 450 15 concentrations concentration NNS cord-347946-i6kx3n6m 450 16 of of IN cord-347946-i6kx3n6m 450 17 the the DT cord-347946-i6kx3n6m 450 18 cytokine cytokine NN cord-347946-i6kx3n6m 450 19 transforming transform VBG cord-347946-i6kx3n6m 450 20 growth growth NN cord-347946-i6kx3n6m 450 21 factor factor NN cord-347946-i6kx3n6m 450 22 ( ( -LRB- cord-347946-i6kx3n6m 450 23 TGF)-β2 tgf)-β2 FW cord-347946-i6kx3n6m 450 24 . . . cord-347946-i6kx3n6m 451 1 TGF TGF NNP cord-347946-i6kx3n6m 451 2 - - HYPH cord-347946-i6kx3n6m 451 3 β2 β2 NNP cord-347946-i6kx3n6m 451 4 has have VBZ cord-347946-i6kx3n6m 451 5 complex complex JJ cord-347946-i6kx3n6m 451 6 pro pro JJ cord-347946-i6kx3n6m 451 7 - - JJ cord-347946-i6kx3n6m 451 8 and and CC cord-347946-i6kx3n6m 451 9 antiinflammatory antiinflammatory JJ cord-347946-i6kx3n6m 451 10 effects effect NNS cord-347946-i6kx3n6m 451 11 ( ( -LRB- cord-347946-i6kx3n6m 451 12 Kondo Kondo NNP cord-347946-i6kx3n6m 451 13 et et FW cord-347946-i6kx3n6m 451 14 al al NNP cord-347946-i6kx3n6m 451 15 , , , cord-347946-i6kx3n6m 451 16 2011 2011 CD cord-347946-i6kx3n6m 451 17 ) ) -RRB- cord-347946-i6kx3n6m 451 18 , , , cord-347946-i6kx3n6m 451 19 but but CC cord-347946-i6kx3n6m 451 20 in in IN cord-347946-i6kx3n6m 451 21 the the DT cord-347946-i6kx3n6m 451 22 context context NN cord-347946-i6kx3n6m 451 23 of of IN cord-347946-i6kx3n6m 451 24 the the DT cord-347946-i6kx3n6m 451 25 newborn newborn JJ cord-347946-i6kx3n6m 451 26 immune immune JJ cord-347946-i6kx3n6m 451 27 system system NN cord-347946-i6kx3n6m 451 28 , , , cord-347946-i6kx3n6m 451 29 it -PRON- PRP cord-347946-i6kx3n6m 451 30 has have VBZ cord-347946-i6kx3n6m 451 31 been be VBN cord-347946-i6kx3n6m 451 32 shown show VBN cord-347946-i6kx3n6m 451 33 to to TO cord-347946-i6kx3n6m 451 34 have have VB cord-347946-i6kx3n6m 451 35 a a DT cord-347946-i6kx3n6m 451 36 key key JJ cord-347946-i6kx3n6m 451 37 role role NN cord-347946-i6kx3n6m 451 38 in in IN cord-347946-i6kx3n6m 451 39 establishing establish VBG cord-347946-i6kx3n6m 451 40 the the DT cord-347946-i6kx3n6m 451 41 mucosal mucosal JJ cord-347946-i6kx3n6m 451 42 immune immune JJ cord-347946-i6kx3n6m 451 43 response response NN cord-347946-i6kx3n6m 451 44 , , , cord-347946-i6kx3n6m 451 45 including include VBG cord-347946-i6kx3n6m 451 46 production production NN cord-347946-i6kx3n6m 451 47 of of IN cord-347946-i6kx3n6m 451 48 secretory secretory JJ cord-347946-i6kx3n6m 451 49 immunoglobulin immunoglobulin NN cord-347946-i6kx3n6m 451 50 A a NN cord-347946-i6kx3n6m 452 1 ( ( -LRB- cord-347946-i6kx3n6m 452 2 Ogawa Ogawa NNP cord-347946-i6kx3n6m 452 3 et et NNP cord-347946-i6kx3n6m 452 4 al al NNP cord-347946-i6kx3n6m 452 5 , , , cord-347946-i6kx3n6m 452 6 2004 2004 CD cord-347946-i6kx3n6m 452 7 ; ; : cord-347946-i6kx3n6m 452 8 Oddy Oddy NNP cord-347946-i6kx3n6m 452 9 and and CC cord-347946-i6kx3n6m 452 10 Rosales Rosales NNP cord-347946-i6kx3n6m 452 11 , , , cord-347946-i6kx3n6m 452 12 2010 2010 CD cord-347946-i6kx3n6m 452 13 ) ) -RRB- cord-347946-i6kx3n6m 452 14 . . . cord-347946-i6kx3n6m 453 1 Also also RB cord-347946-i6kx3n6m 453 2 of of IN cord-347946-i6kx3n6m 453 3 potential potential JJ cord-347946-i6kx3n6m 453 4 relevance relevance NN cord-347946-i6kx3n6m 453 5 , , , cord-347946-i6kx3n6m 453 6 reduced reduced JJ cord-347946-i6kx3n6m 453 7 levels level NNS cord-347946-i6kx3n6m 453 8 of of IN cord-347946-i6kx3n6m 453 9 TGF TGF NNP cord-347946-i6kx3n6m 453 10 - - HYPH cord-347946-i6kx3n6m 453 11 β β NN cord-347946-i6kx3n6m 453 12 have have VBP cord-347946-i6kx3n6m 453 13 been be VBN cord-347946-i6kx3n6m 453 14 associated associate VBN cord-347946-i6kx3n6m 453 15 with with IN cord-347946-i6kx3n6m 453 16 increased increase VBN cord-347946-i6kx3n6m 453 17 symptom symptom NN cord-347946-i6kx3n6m 453 18 severity severity NN cord-347946-i6kx3n6m 453 19 in in IN cord-347946-i6kx3n6m 453 20 children child NNS cord-347946-i6kx3n6m 453 21 infected infect VBN cord-347946-i6kx3n6m 453 22 with with IN cord-347946-i6kx3n6m 453 23 Plasmodium plasmodium NN cord-347946-i6kx3n6m 453 24 falciparum falciparum NN cord-347946-i6kx3n6m 453 25 ( ( -LRB- cord-347946-i6kx3n6m 453 26 Chaiyaroj Chaiyaroj NNP cord-347946-i6kx3n6m 453 27 et et NNP cord-347946-i6kx3n6m 453 28 al al NNP cord-347946-i6kx3n6m 453 29 , , , cord-347946-i6kx3n6m 453 30 2004 2004 CD cord-347946-i6kx3n6m 453 31 ; ; : cord-347946-i6kx3n6m 453 32 Rovira Rovira NNP cord-347946-i6kx3n6m 453 33 - - HYPH cord-347946-i6kx3n6m 453 34 Vallbona Vallbona NNP cord-347946-i6kx3n6m 453 35 et et NNP cord-347946-i6kx3n6m 453 36 al al NNP cord-347946-i6kx3n6m 453 37 , , , cord-347946-i6kx3n6m 453 38 2012 2012 CD cord-347946-i6kx3n6m 453 39 ) ) -RRB- cord-347946-i6kx3n6m 453 40 , , , cord-347946-i6kx3n6m 453 41 suggesting suggest VBG cord-347946-i6kx3n6m 453 42 that that IN cord-347946-i6kx3n6m 453 43 the the DT cord-347946-i6kx3n6m 453 44 provision provision NN cord-347946-i6kx3n6m 453 45 of of IN cord-347946-i6kx3n6m 453 46 increased increase VBN cord-347946-i6kx3n6m 453 47 TGF TGF NNP cord-347946-i6kx3n6m 453 48 - - HYPH cord-347946-i6kx3n6m 453 49 β2 β2 NN cord-347946-i6kx3n6m 453 50 in in IN cord-347946-i6kx3n6m 453 51 breast breast NN cord-347946-i6kx3n6m 453 52 milk milk NN cord-347946-i6kx3n6m 453 53 from from IN cord-347946-i6kx3n6m 453 54 depressed depressed JJ cord-347946-i6kx3n6m 453 55 mothers mother NNS cord-347946-i6kx3n6m 453 56 might may MD cord-347946-i6kx3n6m 453 57 confer confer VB cord-347946-i6kx3n6m 453 58 some some DT cord-347946-i6kx3n6m 453 59 protection protection NN cord-347946-i6kx3n6m 453 60 against against IN cord-347946-i6kx3n6m 453 61 malaria malaria NN cord-347946-i6kx3n6m 453 62 , , , cord-347946-i6kx3n6m 453 63 which which WDT cord-347946-i6kx3n6m 453 64 has have VBZ cord-347946-i6kx3n6m 453 65 been be VBN cord-347946-i6kx3n6m 453 66 a a DT cord-347946-i6kx3n6m 453 67 primary primary JJ cord-347946-i6kx3n6m 453 68 source source NN cord-347946-i6kx3n6m 453 69 of of IN cord-347946-i6kx3n6m 453 70 pathogen pathogen NN cord-347946-i6kx3n6m 453 71 - - HYPH cord-347946-i6kx3n6m 453 72 induced induce VBN cord-347946-i6kx3n6m 453 73 mortality mortality NN cord-347946-i6kx3n6m 453 74 across across IN cord-347946-i6kx3n6m 453 75 human human JJ cord-347946-i6kx3n6m 453 76 evolution evolution NN cord-347946-i6kx3n6m 453 77 . . . cord-347946-i6kx3n6m 454 1 Importantly importantly RB cord-347946-i6kx3n6m 454 2 , , , cord-347946-i6kx3n6m 454 3 TGF TGF NNP cord-347946-i6kx3n6m 454 4 - - HYPH cord-347946-i6kx3n6m 454 5 β β NNP cord-347946-i6kx3n6m 454 6 and and CC cord-347946-i6kx3n6m 454 7 other other JJ cord-347946-i6kx3n6m 454 8 immune immune JJ cord-347946-i6kx3n6m 454 9 factors factor NNS cord-347946-i6kx3n6m 454 10 in in IN cord-347946-i6kx3n6m 454 11 breast breast NN cord-347946-i6kx3n6m 454 12 milk milk NN cord-347946-i6kx3n6m 454 13 remain remain VBP cord-347946-i6kx3n6m 454 14 biologically biologically RB cord-347946-i6kx3n6m 454 15 active active JJ cord-347946-i6kx3n6m 454 16 after after IN cord-347946-i6kx3n6m 454 17 passage passage NN cord-347946-i6kx3n6m 454 18 through through IN cord-347946-i6kx3n6m 454 19 the the DT cord-347946-i6kx3n6m 454 20 infant infant NN cord-347946-i6kx3n6m 454 21 stomach stomach NN cord-347946-i6kx3n6m 454 22 as as IN cord-347946-i6kx3n6m 454 23 a a DT cord-347946-i6kx3n6m 454 24 result result NN cord-347946-i6kx3n6m 454 25 of of IN cord-347946-i6kx3n6m 454 26 its -PRON- PRP$ cord-347946-i6kx3n6m 454 27 higher high JJR cord-347946-i6kx3n6m 454 28 pH ph NN cord-347946-i6kx3n6m 454 29 ( ( -LRB- cord-347946-i6kx3n6m 454 30 Hennet Hennet NNP cord-347946-i6kx3n6m 454 31 and and CC cord-347946-i6kx3n6m 454 32 Borsig Borsig NNP cord-347946-i6kx3n6m 454 33 , , , cord-347946-i6kx3n6m 454 34 2016 2016 CD cord-347946-i6kx3n6m 454 35 ) ) -RRB- cord-347946-i6kx3n6m 454 36 . . . cord-347946-i6kx3n6m 455 1 In in IN cord-347946-i6kx3n6m 455 2 essence essence NN cord-347946-i6kx3n6m 455 3 , , , cord-347946-i6kx3n6m 455 4 PATHOS pathos NN cord-347946-i6kx3n6m 455 5 - - HYPH cord-347946-i6kx3n6m 455 6 D D NNP cord-347946-i6kx3n6m 455 7 does do VBZ cord-347946-i6kx3n6m 455 8 nothing nothing NN cord-347946-i6kx3n6m 455 9 more more JJR cord-347946-i6kx3n6m 455 10 than than IN cord-347946-i6kx3n6m 455 11 attempt attempt NN cord-347946-i6kx3n6m 455 12 to to TO cord-347946-i6kx3n6m 455 13 instantiate instantiate VB cord-347946-i6kx3n6m 455 14 and and CC cord-347946-i6kx3n6m 455 15 provide provide VB cord-347946-i6kx3n6m 455 16 specifics specific NNS cord-347946-i6kx3n6m 455 17 to to IN cord-347946-i6kx3n6m 455 18 the the DT cord-347946-i6kx3n6m 455 19 observation observation NN cord-347946-i6kx3n6m 455 20 from from IN cord-347946-i6kx3n6m 455 21 the the DT cord-347946-i6kx3n6m 455 22 quote quote NN cord-347946-i6kx3n6m 455 23 that that WDT cord-347946-i6kx3n6m 455 24 started start VBD cord-347946-i6kx3n6m 455 25 this this DT cord-347946-i6kx3n6m 455 26 article article NN cord-347946-i6kx3n6m 455 27 , , , cord-347946-i6kx3n6m 455 28 that that IN cord-347946-i6kx3n6m 455 29 ' ' `` cord-347946-i6kx3n6m 455 30 the the DT cord-347946-i6kx3n6m 455 31 only only RB cord-347946-i6kx3n6m 455 32 … … NFP cord-347946-i6kx3n6m 455 33 compensating compensate VBG cord-347946-i6kx3n6m 455 34 fitness fitness NN cord-347946-i6kx3n6m 455 35 benefit benefit NN cord-347946-i6kx3n6m 455 36 that that WDT cord-347946-i6kx3n6m 455 37 has have VBZ cord-347946-i6kx3n6m 455 38 been be VBN cord-347946-i6kx3n6m 455 39 documented document VBN cord-347946-i6kx3n6m 455 40 for for IN cord-347946-i6kx3n6m 455 41 major major JJ cord-347946-i6kx3n6m 455 42 human human JJ cord-347946-i6kx3n6m 455 43 genetic genetic JJ cord-347946-i6kx3n6m 455 44 diseases disease NNS cord-347946-i6kx3n6m 455 45 is be VBZ cord-347946-i6kx3n6m 455 46 resistance resistance NN cord-347946-i6kx3n6m 455 47 to to IN cord-347946-i6kx3n6m 455 48 infection infection NN cord-347946-i6kx3n6m 455 49 ' ' '' cord-347946-i6kx3n6m 456 1 ( ( -LRB- cord-347946-i6kx3n6m 456 2 Cochran Cochran NNP cord-347946-i6kx3n6m 456 3 et et NNP cord-347946-i6kx3n6m 456 4 al al NNP cord-347946-i6kx3n6m 456 5 , , , cord-347946-i6kx3n6m 456 6 2000 2000 CD cord-347946-i6kx3n6m 456 7 ) ) -RRB- cord-347946-i6kx3n6m 456 8 . . . cord-347946-i6kx3n6m 457 1 We -PRON- PRP cord-347946-i6kx3n6m 457 2 have have VBP cord-347946-i6kx3n6m 457 3 argued argue VBN cord-347946-i6kx3n6m 457 4 that that IN cord-347946-i6kx3n6m 457 5 depression depression NN cord-347946-i6kx3n6m 457 6 and and CC cord-347946-i6kx3n6m 457 7 its -PRON- PRP$ cord-347946-i6kx3n6m 457 8 relationship relationship NN cord-347946-i6kx3n6m 457 9 with with IN cord-347946-i6kx3n6m 457 10 inflammation inflammation NN cord-347946-i6kx3n6m 457 11 and and CC cord-347946-i6kx3n6m 457 12 in in IN cord-347946-i6kx3n6m 457 13 particular particular JJ cord-347946-i6kx3n6m 457 14 the the DT cord-347946-i6kx3n6m 457 15 acute acute JJ cord-347946-i6kx3n6m 457 16 phase phase NN cord-347946-i6kx3n6m 457 17 response response NN cord-347946-i6kx3n6m 457 18 is be VBZ cord-347946-i6kx3n6m 457 19 yet yet RB cord-347946-i6kx3n6m 457 20 another another DT cord-347946-i6kx3n6m 457 21 example example NN cord-347946-i6kx3n6m 457 22 of of IN cord-347946-i6kx3n6m 457 23 this this DT cord-347946-i6kx3n6m 457 24 evolutionary evolutionary JJ cord-347946-i6kx3n6m 457 25 reality reality NN cord-347946-i6kx3n6m 457 26 , , , cord-347946-i6kx3n6m 457 27 providing provide VBG cord-347946-i6kx3n6m 457 28 insights insight NNS cord-347946-i6kx3n6m 457 29 into into IN cord-347946-i6kx3n6m 457 30 the the DT cord-347946-i6kx3n6m 457 31 puzzling puzzling JJ cord-347946-i6kx3n6m 457 32 lack lack NN cord-347946-i6kx3n6m 457 33 of of IN cord-347946-i6kx3n6m 457 34 consistency consistency NN cord-347946-i6kx3n6m 457 35 of of IN cord-347946-i6kx3n6m 457 36 risk risk NN cord-347946-i6kx3n6m 457 37 alleles allele NNS cord-347946-i6kx3n6m 457 38 across across IN cord-347946-i6kx3n6m 457 39 populations population NNS cord-347946-i6kx3n6m 457 40 as as RB cord-347946-i6kx3n6m 457 41 well well RB cord-347946-i6kx3n6m 457 42 as as IN cord-347946-i6kx3n6m 457 43 the the DT cord-347946-i6kx3n6m 457 44 epidemiology epidemiology NN cord-347946-i6kx3n6m 457 45 of of IN cord-347946-i6kx3n6m 457 46 the the DT cord-347946-i6kx3n6m 457 47 disorder disorder NN cord-347946-i6kx3n6m 457 48 including include VBG cord-347946-i6kx3n6m 457 49 its -PRON- PRP$ cord-347946-i6kx3n6m 457 50 risk risk NN cord-347946-i6kx3n6m 457 51 factors factor NNS cord-347946-i6kx3n6m 457 52 in in IN cord-347946-i6kx3n6m 457 53 ancient ancient JJ cord-347946-i6kx3n6m 457 54 and and CC cord-347946-i6kx3n6m 457 55 modern modern JJ cord-347946-i6kx3n6m 457 56 times time NNS cord-347946-i6kx3n6m 457 57 and and CC cord-347946-i6kx3n6m 457 58 its -PRON- PRP$ cord-347946-i6kx3n6m 457 59 age age NN cord-347946-i6kx3n6m 457 60 of of IN cord-347946-i6kx3n6m 457 61 onset onset NN cord-347946-i6kx3n6m 457 62 and and CC cord-347946-i6kx3n6m 457 63 female female JJ cord-347946-i6kx3n6m 457 64 preponderance preponderance NN cord-347946-i6kx3n6m 457 65 . . . cord-347946-i6kx3n6m 458 1 Funding fund VBG cord-347946-i6kx3n6m 458 2 for for IN cord-347946-i6kx3n6m 458 3 this this DT cord-347946-i6kx3n6m 458 4 study study NN cord-347946-i6kx3n6m 458 5 was be VBD cord-347946-i6kx3n6m 458 6 provided provide VBN cord-347946-i6kx3n6m 458 7 for for IN cord-347946-i6kx3n6m 458 8 CLR CLR NNP cord-347946-i6kx3n6m 458 9 by by IN cord-347946-i6kx3n6m 458 10 Mary Mary NNP cord-347946-i6kx3n6m 458 11 Sue Sue NNP cord-347946-i6kx3n6m 458 12 and and CC cord-347946-i6kx3n6m 458 13 Mike Mike NNP cord-347946-i6kx3n6m 458 14 Shannon Shannon NNP cord-347946-i6kx3n6m 458 15 , , , cord-347946-i6kx3n6m 458 16 the the DT cord-347946-i6kx3n6m 458 17 Usona Usona NNP cord-347946-i6kx3n6m 458 18 Institute Institute NNP cord-347946-i6kx3n6m 458 19 and and CC cord-347946-i6kx3n6m 458 20 the the DT cord-347946-i6kx3n6m 458 21 University University NNP cord-347946-i6kx3n6m 458 22 of of IN cord-347946-i6kx3n6m 458 23 Wisconsin Wisconsin NNP cord-347946-i6kx3n6m 458 24 - - HYPH cord-347946-i6kx3n6m 458 25 Madison Madison NNP cord-347946-i6kx3n6m 458 26 and and CC cord-347946-i6kx3n6m 458 27 for for IN cord-347946-i6kx3n6m 458 28 AHM AHM NNP cord-347946-i6kx3n6m 458 29 by by IN cord-347946-i6kx3n6m 458 30 R03MH100273 r03mh100273 NN cord-347946-i6kx3n6m 458 31 ; ; : cord-347946-i6kx3n6m 458 32 R01MH087604 R01MH087604 NNP cord-347946-i6kx3n6m 458 33 ; ; : cord-347946-i6kx3n6m 459 1 Supported support VBN cord-347946-i6kx3n6m 459 2 In in IN cord-347946-i6kx3n6m 459 3 part part NN cord-347946-i6kx3n6m 459 4 by by IN cord-347946-i6kx3n6m 459 5 the the DT cord-347946-i6kx3n6m 459 6 National National NNP cord-347946-i6kx3n6m 459 7 Center Center NNP cord-347946-i6kx3n6m 459 8 for for IN cord-347946-i6kx3n6m 459 9 Advancing advance VBG cord-347946-i6kx3n6m 459 10 Translational Translational NNP cord-347946-i6kx3n6m 459 11 Sciences Sciences NNPS cord-347946-i6kx3n6m 459 12 of of IN cord-347946-i6kx3n6m 459 13 the the DT cord-347946-i6kx3n6m 459 14 National National NNP cord-347946-i6kx3n6m 459 15 Institutes Institutes NNPS cord-347946-i6kx3n6m 459 16 of of IN cord-347946-i6kx3n6m 459 17 Health Health NNP cord-347946-i6kx3n6m 459 18 under under IN cord-347946-i6kx3n6m 459 19 Award Award NNP cord-347946-i6kx3n6m 459 20 number number NN cord-347946-i6kx3n6m 459 21 UL1TR000454 UL1TR000454 NNP cord-347946-i6kx3n6m 459 22 . . . cord-347946-i6kx3n6m 460 1 The the DT cord-347946-i6kx3n6m 460 2 content content NN cord-347946-i6kx3n6m 460 3 is be VBZ cord-347946-i6kx3n6m 460 4 solely solely RB cord-347946-i6kx3n6m 460 5 the the DT cord-347946-i6kx3n6m 460 6 responsibility responsibility NN cord-347946-i6kx3n6m 460 7 of of IN cord-347946-i6kx3n6m 460 8 the the DT cord-347946-i6kx3n6m 460 9 authors author NNS cord-347946-i6kx3n6m 460 10 and and CC cord-347946-i6kx3n6m 460 11 does do VBZ cord-347946-i6kx3n6m 460 12 not not RB cord-347946-i6kx3n6m 460 13 necessarily necessarily RB cord-347946-i6kx3n6m 460 14 represent represent VB cord-347946-i6kx3n6m 460 15 the the DT cord-347946-i6kx3n6m 460 16 official official JJ cord-347946-i6kx3n6m 460 17 views view NNS cord-347946-i6kx3n6m 460 18 of of IN cord-347946-i6kx3n6m 460 19 the the DT cord-347946-i6kx3n6m 460 20 National National NNP cord-347946-i6kx3n6m 460 21 Institutes Institutes NNPS cord-347946-i6kx3n6m 460 22 of of IN cord-347946-i6kx3n6m 460 23 Health Health NNP cord-347946-i6kx3n6m 460 24 . . . cord-347946-i6kx3n6m 461 1 Study study NN cord-347946-i6kx3n6m 461 2 funders funder NNS cord-347946-i6kx3n6m 461 3 had have VBD cord-347946-i6kx3n6m 461 4 no no DT cord-347946-i6kx3n6m 461 5 role role NN cord-347946-i6kx3n6m 461 6 in in IN cord-347946-i6kx3n6m 461 7 the the DT cord-347946-i6kx3n6m 461 8 design design NN cord-347946-i6kx3n6m 461 9 and and CC cord-347946-i6kx3n6m 461 10 conduct conduct NN cord-347946-i6kx3n6m 461 11 of of IN cord-347946-i6kx3n6m 461 12 the the DT cord-347946-i6kx3n6m 461 13 study study NN cord-347946-i6kx3n6m 461 14 ; ; : cord-347946-i6kx3n6m 461 15 collection collection NN cord-347946-i6kx3n6m 461 16 , , , cord-347946-i6kx3n6m 461 17 management management NN cord-347946-i6kx3n6m 461 18 , , , cord-347946-i6kx3n6m 461 19 analysis analysis NN cord-347946-i6kx3n6m 461 20 and and CC cord-347946-i6kx3n6m 461 21 interpretation interpretation NN cord-347946-i6kx3n6m 461 22 of of IN cord-347946-i6kx3n6m 461 23 the the DT cord-347946-i6kx3n6m 461 24 data datum NNS cord-347946-i6kx3n6m 461 25 ; ; : cord-347946-i6kx3n6m 461 26 preparation preparation NN cord-347946-i6kx3n6m 461 27 , , , cord-347946-i6kx3n6m 461 28 review review NN cord-347946-i6kx3n6m 461 29 , , , cord-347946-i6kx3n6m 461 30 or or CC cord-347946-i6kx3n6m 461 31 approval approval NN cord-347946-i6kx3n6m 461 32 of of IN cord-347946-i6kx3n6m 461 33 the the DT cord-347946-i6kx3n6m 461 34 manuscript manuscript NN cord-347946-i6kx3n6m 461 35 ; ; : cord-347946-i6kx3n6m 461 36 and and CC cord-347946-i6kx3n6m 461 37 decision decision NN cord-347946-i6kx3n6m 461 38 to to TO cord-347946-i6kx3n6m 461 39 submit submit VB cord-347946-i6kx3n6m 461 40 the the DT cord-347946-i6kx3n6m 461 41 manuscript manuscript NN cord-347946-i6kx3n6m 461 42 for for IN cord-347946-i6kx3n6m 461 43 publication publication NN cord-347946-i6kx3n6m 461 44 . . . cord-347946-i6kx3n6m 462 1 Dr Dr NNP cord-347946-i6kx3n6m 462 2 Raison Raison NNP cord-347946-i6kx3n6m 462 3 serves serve VBZ cord-347946-i6kx3n6m 462 4 on on IN cord-347946-i6kx3n6m 462 5 the the DT cord-347946-i6kx3n6m 462 6 Scientific Scientific NNP cord-347946-i6kx3n6m 462 7 Advisory Advisory NNP cord-347946-i6kx3n6m 462 8 Board Board NNP cord-347946-i6kx3n6m 462 9 for for IN cord-347946-i6kx3n6m 462 10 Usona Usona NNP cord-347946-i6kx3n6m 462 11 Institute Institute NNP cord-347946-i6kx3n6m 462 12 . . . cord-347946-i6kx3n6m 463 1 Dr Dr NNP cord-347946-i6kx3n6m 463 2 Miller Miller NNP cord-347946-i6kx3n6m 463 3 reports report VBZ cord-347946-i6kx3n6m 463 4 no no DT cord-347946-i6kx3n6m 463 5 conflicts conflict NNS cord-347946-i6kx3n6m 463 6 of of IN cord-347946-i6kx3n6m 463 7 interest interest NN cord-347946-i6kx3n6m 463 8 . . . cord-347946-i6kx3n6m 464 1 Hippocampal hippocampal NN cord-347946-i6kx3n6m 464 2 sirtuin sirtuin NN cord-347946-i6kx3n6m 464 3 1 1 CD cord-347946-i6kx3n6m 464 4 signaling signaling NN cord-347946-i6kx3n6m 464 5 mediates mediate VBZ cord-347946-i6kx3n6m 464 6 depression depression NN cord-347946-i6kx3n6m 464 7 - - HYPH cord-347946-i6kx3n6m 464 8 like like JJ cord-347946-i6kx3n6m 464 9 behavior behavior NN cord-347946-i6kx3n6m 465 1 Targeting target VBG cord-347946-i6kx3n6m 465 2 sirtuin-1 sirtuin-1 NNP cord-347946-i6kx3n6m 465 3 alleviates alleviate VBZ cord-347946-i6kx3n6m 465 4 experimental experimental JJ cord-347946-i6kx3n6m 465 5 autoimmune autoimmune JJ cord-347946-i6kx3n6m 465 6 colitis colitis NN cord-347946-i6kx3n6m 465 7 by by IN cord-347946-i6kx3n6m 465 8 induction induction NN cord-347946-i6kx3n6m 465 9 of of IN cord-347946-i6kx3n6m 465 10 Foxp3 Foxp3 NNP cord-347946-i6kx3n6m 465 11 + + CC cord-347946-i6kx3n6m 465 12 T t NN cord-347946-i6kx3n6m 465 13 - - HYPH cord-347946-i6kx3n6m 465 14 regulatory regulatory JJ cord-347946-i6kx3n6m 465 15 cells cell NNS cord-347946-i6kx3n6m 465 16 Depression depression NN cord-347946-i6kx3n6m 465 17 as as IN cord-347946-i6kx3n6m 465 18 an an DT cord-347946-i6kx3n6m 465 19 evolutionary evolutionary JJ cord-347946-i6kx3n6m 465 20 strategy strategy NN cord-347946-i6kx3n6m 465 21 for for IN cord-347946-i6kx3n6m 465 22 defense defense NN cord-347946-i6kx3n6m 465 23 against against IN cord-347946-i6kx3n6m 465 24 infection infection NN cord-347946-i6kx3n6m 465 25 Depression Depression NNP cord-347946-i6kx3n6m 465 26 and and CC cord-347946-i6kx3n6m 465 27 the the DT cord-347946-i6kx3n6m 465 28 risk risk NN cord-347946-i6kx3n6m 465 29 of of IN cord-347946-i6kx3n6m 465 30 severe severe JJ cord-347946-i6kx3n6m 465 31 infections infection NNS cord-347946-i6kx3n6m 465 32 : : : cord-347946-i6kx3n6m 465 33 prospective prospective JJ cord-347946-i6kx3n6m 465 34 analyses analysis NNS cord-347946-i6kx3n6m 465 35 on on IN cord-347946-i6kx3n6m 466 1 a a DT cord-347946-i6kx3n6m 466 2 nationwide nationwide JJ cord-347946-i6kx3n6m 466 3 representative representative JJ cord-347946-i6kx3n6m 466 4 sample sample NN cord-347946-i6kx3n6m 466 5 Celecoxib Celecoxib NNP cord-347946-i6kx3n6m 466 6 sensitizes sensitize VBZ cord-347946-i6kx3n6m 466 7 Staphylococcus staphylococcus NN cord-347946-i6kx3n6m 466 8 aureus aureus NN cord-347946-i6kx3n6m 466 9 to to IN cord-347946-i6kx3n6m 466 10 antibiotics antibiotic NNS cord-347946-i6kx3n6m 466 11 in in IN cord-347946-i6kx3n6m 466 12 macrophages macrophage NNS cord-347946-i6kx3n6m 466 13 by by IN cord-347946-i6kx3n6m 466 14 modulating modulate VBG cord-347946-i6kx3n6m 466 15 SIRT1 SIRT1 NNP cord-347946-i6kx3n6m 466 16 Cytokine cytokine NN cord-347946-i6kx3n6m 466 17 gene gene NN cord-347946-i6kx3n6m 466 18 polymorphisms polymorphism NNS cord-347946-i6kx3n6m 466 19 across across IN cord-347946-i6kx3n6m 466 20 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 466 21 clinical clinical JJ cord-347946-i6kx3n6m 466 22 spectrum spectrum NN cord-347946-i6kx3n6m 466 23 in in IN cord-347946-i6kx3n6m 466 24 Pakistani pakistani JJ cord-347946-i6kx3n6m 466 25 patients patient NNS cord-347946-i6kx3n6m 466 26 Evolutionary evolutionary JJ cord-347946-i6kx3n6m 466 27 , , , cord-347946-i6kx3n6m 466 28 historical historical JJ cord-347946-i6kx3n6m 466 29 and and CC cord-347946-i6kx3n6m 466 30 political political JJ cord-347946-i6kx3n6m 466 31 economic economic JJ cord-347946-i6kx3n6m 466 32 perspectives perspective NNS cord-347946-i6kx3n6m 466 33 on on IN cord-347946-i6kx3n6m 466 34 health health NN cord-347946-i6kx3n6m 466 35 and and CC cord-347946-i6kx3n6m 466 36 disease disease NN cord-347946-i6kx3n6m 466 37 Maintenance maintenance NN cord-347946-i6kx3n6m 466 38 of of IN cord-347946-i6kx3n6m 466 39 a a DT cord-347946-i6kx3n6m 466 40 positive positive JJ cord-347946-i6kx3n6m 466 41 outlook outlook NN cord-347946-i6kx3n6m 466 42 during during IN cord-347946-i6kx3n6m 466 43 acute acute JJ cord-347946-i6kx3n6m 466 44 stress stress NN cord-347946-i6kx3n6m 466 45 protects protect VBZ cord-347946-i6kx3n6m 466 46 against against IN cord-347946-i6kx3n6m 466 47 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 466 48 reactivity reactivity NN cord-347946-i6kx3n6m 466 49 and and CC cord-347946-i6kx3n6m 466 50 future future JJ cord-347946-i6kx3n6m 466 51 depressive depressive JJ cord-347946-i6kx3n6m 466 52 symptoms symptom NNS cord-347946-i6kx3n6m 467 1 Diagnostic diagnostic JJ cord-347946-i6kx3n6m 467 2 and and CC cord-347946-i6kx3n6m 467 3 statistical statistical JJ cord-347946-i6kx3n6m 467 4 manual manual NN cord-347946-i6kx3n6m 467 5 of of IN cord-347946-i6kx3n6m 467 6 mental mental JJ cord-347946-i6kx3n6m 467 7 disorders disorder NNS cord-347946-i6kx3n6m 467 8 Could Could MD cord-347946-i6kx3n6m 467 9 viruses virus NNS cord-347946-i6kx3n6m 467 10 contribute contribute VB cord-347946-i6kx3n6m 467 11 to to IN cord-347946-i6kx3n6m 467 12 the the DT cord-347946-i6kx3n6m 467 13 worldwide worldwide JJ cord-347946-i6kx3n6m 467 14 epidemic epidemic NN cord-347946-i6kx3n6m 467 15 of of IN cord-347946-i6kx3n6m 467 16 obesity obesity NN cord-347946-i6kx3n6m 467 17 ? ? . cord-347946-i6kx3n6m 468 1 Compared compare VBN cord-347946-i6kx3n6m 468 2 effects effect NNS cord-347946-i6kx3n6m 468 3 of of IN cord-347946-i6kx3n6m 468 4 cold cold JJ cord-347946-i6kx3n6m 468 5 ambient ambient JJ cord-347946-i6kx3n6m 468 6 temperature temperature NN cord-347946-i6kx3n6m 468 7 and and CC cord-347946-i6kx3n6m 468 8 cytokines cytokine NNS cord-347946-i6kx3n6m 468 9 on on IN cord-347946-i6kx3n6m 468 10 macronutrient macronutrient NN cord-347946-i6kx3n6m 468 11 intake intake NN cord-347946-i6kx3n6m 468 12 in in IN cord-347946-i6kx3n6m 468 13 rats rat NNS cord-347946-i6kx3n6m 468 14 Social social JJ cord-347946-i6kx3n6m 468 15 stress stress NN cord-347946-i6kx3n6m 468 16 and and CC cord-347946-i6kx3n6m 468 17 the the DT cord-347946-i6kx3n6m 468 18 regulation regulation NN cord-347946-i6kx3n6m 468 19 of of IN cord-347946-i6kx3n6m 468 20 tumor tumor NN cord-347946-i6kx3n6m 468 21 necrosis necrosis NN cord-347946-i6kx3n6m 468 22 factor factor NN cord-347946-i6kx3n6m 468 23 - - HYPH cord-347946-i6kx3n6m 468 24 alpha alpha NN cord-347946-i6kx3n6m 468 25 secretion secretion NN cord-347946-i6kx3n6m 468 26 Sex sex NN cord-347946-i6kx3n6m 468 27 differences difference NNS cord-347946-i6kx3n6m 468 28 in in IN cord-347946-i6kx3n6m 468 29 the the DT cord-347946-i6kx3n6m 468 30 response response NN cord-347946-i6kx3n6m 468 31 to to IN cord-347946-i6kx3n6m 468 32 influenza influenza NN cord-347946-i6kx3n6m 468 33 virus virus NN cord-347946-i6kx3n6m 468 34 infection infection NN cord-347946-i6kx3n6m 468 35 : : : cord-347946-i6kx3n6m 468 36 modulation modulation NN cord-347946-i6kx3n6m 468 37 by by IN cord-347946-i6kx3n6m 468 38 stress stress NN cord-347946-i6kx3n6m 469 1 The the DT cord-347946-i6kx3n6m 469 2 immunobiology immunobiology NN cord-347946-i6kx3n6m 469 3 of of IN cord-347946-i6kx3n6m 469 4 sexual sexual JJ cord-347946-i6kx3n6m 469 5 behavior behavior NN cord-347946-i6kx3n6m 469 6 : : : cord-347946-i6kx3n6m 469 7 gender gender NN cord-347946-i6kx3n6m 469 8 differences difference NNS cord-347946-i6kx3n6m 469 9 in in IN cord-347946-i6kx3n6m 469 10 the the DT cord-347946-i6kx3n6m 469 11 suppression suppression NN cord-347946-i6kx3n6m 469 12 of of IN cord-347946-i6kx3n6m 469 13 sexual sexual JJ cord-347946-i6kx3n6m 469 14 activity activity NN cord-347946-i6kx3n6m 469 15 during during IN cord-347946-i6kx3n6m 469 16 illness illness NN cord-347946-i6kx3n6m 470 1 Repeated repeat VBN cord-347946-i6kx3n6m 470 2 social social JJ cord-347946-i6kx3n6m 470 3 defeat defeat NN cord-347946-i6kx3n6m 470 4 increases increase VBZ cord-347946-i6kx3n6m 470 5 the the DT cord-347946-i6kx3n6m 470 6 bactericidal bactericidal JJ cord-347946-i6kx3n6m 470 7 activity activity NN cord-347946-i6kx3n6m 470 8 of of IN cord-347946-i6kx3n6m 470 9 splenic splenic JJ cord-347946-i6kx3n6m 470 10 macrophages macrophage NNS cord-347946-i6kx3n6m 470 11 through through IN cord-347946-i6kx3n6m 470 12 a a DT cord-347946-i6kx3n6m 470 13 Tolllike Tolllike NNP cord-347946-i6kx3n6m 470 14 receptor receptor NN cord-347946-i6kx3n6m 470 15 - - HYPH cord-347946-i6kx3n6m 470 16 dependent dependent JJ cord-347946-i6kx3n6m 470 17 pathway pathway NN cord-347946-i6kx3n6m 470 18 Social social JJ cord-347946-i6kx3n6m 470 19 stress stress NN cord-347946-i6kx3n6m 470 20 enhances enhance VBZ cord-347946-i6kx3n6m 470 21 IL-1beta il-1beta NN cord-347946-i6kx3n6m 470 22 and and CC cord-347946-i6kx3n6m 470 23 TNF tnf NN cord-347946-i6kx3n6m 470 24 - - HYPH cord-347946-i6kx3n6m 470 25 alpha alpha NN cord-347946-i6kx3n6m 470 26 production production NN cord-347946-i6kx3n6m 470 27 by by IN cord-347946-i6kx3n6m 470 28 Porphyromonas Porphyromonas NNP cord-347946-i6kx3n6m 470 29 gingivalis gingivalis NNP cord-347946-i6kx3n6m 470 30 lipopolysaccharide lipopolysaccharide NN cord-347946-i6kx3n6m 470 31 - - HYPH cord-347946-i6kx3n6m 470 32 stimulated stimulate VBN cord-347946-i6kx3n6m 470 33 CD11b+ CD11b+ NNP cord-347946-i6kx3n6m 470 34 cells cell NNS cord-347946-i6kx3n6m 471 1 How how WRB cord-347946-i6kx3n6m 471 2 do do VBP cord-347946-i6kx3n6m 471 3 viral viral JJ cord-347946-i6kx3n6m 471 4 infections infection NNS cord-347946-i6kx3n6m 471 5 predispose predispose VBP cord-347946-i6kx3n6m 471 6 patients patient NNS cord-347946-i6kx3n6m 471 7 to to IN cord-347946-i6kx3n6m 471 8 bacterial bacterial JJ cord-347946-i6kx3n6m 471 9 infections infection NNS cord-347946-i6kx3n6m 471 10 ? ? . cord-347946-i6kx3n6m 472 1 Children child NNS cord-347946-i6kx3n6m 472 2 of of IN cord-347946-i6kx3n6m 472 3 affectively affectively RB cord-347946-i6kx3n6m 472 4 ill ill JJ cord-347946-i6kx3n6m 472 5 parents parent NNS cord-347946-i6kx3n6m 472 6 : : : cord-347946-i6kx3n6m 472 7 a a DT cord-347946-i6kx3n6m 472 8 review review NN cord-347946-i6kx3n6m 472 9 of of IN cord-347946-i6kx3n6m 472 10 the the DT cord-347946-i6kx3n6m 472 11 past past JJ cord-347946-i6kx3n6m 472 12 10 10 CD cord-347946-i6kx3n6m 472 13 years year NNS cord-347946-i6kx3n6m 472 14 Maternal maternal JJ cord-347946-i6kx3n6m 472 15 depression depression NN cord-347946-i6kx3n6m 472 16 and and CC cord-347946-i6kx3n6m 472 17 child child NN cord-347946-i6kx3n6m 472 18 behaviour behaviour NN cord-347946-i6kx3n6m 472 19 problems problem NNS cord-347946-i6kx3n6m 472 20 : : : cord-347946-i6kx3n6m 472 21 a a DT cord-347946-i6kx3n6m 472 22 metaanalysis metaanalysis NN cord-347946-i6kx3n6m 472 23 Genome Genome NNP cord-347946-i6kx3n6m 472 24 - - HYPH cord-347946-i6kx3n6m 472 25 wide wide JJ cord-347946-i6kx3n6m 472 26 association association NN cord-347946-i6kx3n6m 472 27 study study NN cord-347946-i6kx3n6m 472 28 ( ( -LRB- cord-347946-i6kx3n6m 472 29 GWAS)-identified GWAS)-identified NNP cord-347946-i6kx3n6m 472 30 disease disease NN cord-347946-i6kx3n6m 472 31 risk risk NN cord-347946-i6kx3n6m 472 32 alleles allele NNS cord-347946-i6kx3n6m 472 33 do do VBP cord-347946-i6kx3n6m 472 34 not not RB cord-347946-i6kx3n6m 472 35 compromise compromise VB cord-347946-i6kx3n6m 472 36 human human JJ cord-347946-i6kx3n6m 472 37 longevity longevity NN cord-347946-i6kx3n6m 472 38 Autoimmune autoimmune JJ cord-347946-i6kx3n6m 472 39 diseases disease NNS cord-347946-i6kx3n6m 472 40 and and CC cord-347946-i6kx3n6m 472 41 severe severe JJ cord-347946-i6kx3n6m 472 42 infections infection NNS cord-347946-i6kx3n6m 472 43 as as IN cord-347946-i6kx3n6m 472 44 risk risk NN cord-347946-i6kx3n6m 472 45 factors factor NNS cord-347946-i6kx3n6m 472 46 for for IN cord-347946-i6kx3n6m 472 47 mood mood NN cord-347946-i6kx3n6m 472 48 disorders disorder NNS cord-347946-i6kx3n6m 472 49 : : : cord-347946-i6kx3n6m 472 50 a a DT cord-347946-i6kx3n6m 472 51 nationwide nationwide JJ cord-347946-i6kx3n6m 472 52 study study NN cord-347946-i6kx3n6m 472 53 Parental parental JJ cord-347946-i6kx3n6m 472 54 death death NN cord-347946-i6kx3n6m 472 55 during during IN cord-347946-i6kx3n6m 472 56 childhood childhood NN cord-347946-i6kx3n6m 472 57 and and CC cord-347946-i6kx3n6m 472 58 depression depression NN cord-347946-i6kx3n6m 472 59 in in IN cord-347946-i6kx3n6m 472 60 young young JJ cord-347946-i6kx3n6m 472 61 adults adult NNS cord-347946-i6kx3n6m 473 1 -a -a : cord-347946-i6kx3n6m 473 2 national national JJ cord-347946-i6kx3n6m 473 3 cohort cohort NNP cord-347946-i6kx3n6m 473 4 study study NN cord-347946-i6kx3n6m 473 5 Host Host NNP cord-347946-i6kx3n6m 473 6 adaptive adaptive JJ cord-347946-i6kx3n6m 473 7 immunity immunity NN cord-347946-i6kx3n6m 473 8 deficiency deficiency NN cord-347946-i6kx3n6m 473 9 in in IN cord-347946-i6kx3n6m 473 10 severe severe JJ cord-347946-i6kx3n6m 473 11 pandemic pandemic NN cord-347946-i6kx3n6m 473 12 influenza influenza NN cord-347946-i6kx3n6m 474 1 When when WRB cord-347946-i6kx3n6m 474 2 boy boy NN cord-347946-i6kx3n6m 474 3 meets meet VBZ cord-347946-i6kx3n6m 474 4 girl girl NN cord-347946-i6kx3n6m 474 5 : : : cord-347946-i6kx3n6m 474 6 attractiven4ess attractiven4ess NN cord-347946-i6kx3n6m 474 7 and and CC cord-347946-i6kx3n6m 474 8 the the DT cord-347946-i6kx3n6m 474 9 five five CD cord-347946-i6kx3n6m 474 10 - - HYPH cord-347946-i6kx3n6m 474 11 factor factor NN cord-347946-i6kx3n6m 474 12 model model NN cord-347946-i6kx3n6m 474 13 in in IN cord-347946-i6kx3n6m 474 14 opposite opposite JJ cord-347946-i6kx3n6m 474 15 - - HYPH cord-347946-i6kx3n6m 474 16 sex sex NN cord-347946-i6kx3n6m 474 17 interactions interaction NNS cord-347946-i6kx3n6m 475 1 A a DT cord-347946-i6kx3n6m 475 2 mechanism mechanism NN cord-347946-i6kx3n6m 475 3 converting convert VBG cord-347946-i6kx3n6m 475 4 psychosocial psychosocial JJ cord-347946-i6kx3n6m 475 5 stress stress NN cord-347946-i6kx3n6m 475 6 into into IN cord-347946-i6kx3n6m 475 7 mononuclear mononuclear JJ cord-347946-i6kx3n6m 475 8 cell cell NN cord-347946-i6kx3n6m 475 9 activation activation NN cord-347946-i6kx3n6m 475 10 Genetic genetic JJ cord-347946-i6kx3n6m 475 11 variation variation NN cord-347946-i6kx3n6m 475 12 in in IN cord-347946-i6kx3n6m 475 13 CACNA1C CACNA1C NNP cord-347946-i6kx3n6m 475 14 affects affect VBZ cord-347946-i6kx3n6m 475 15 brain brain NN cord-347946-i6kx3n6m 475 16 circuitries circuitry NNS cord-347946-i6kx3n6m 475 17 related relate VBN cord-347946-i6kx3n6m 475 18 to to IN cord-347946-i6kx3n6m 475 19 mental mental JJ cord-347946-i6kx3n6m 475 20 illness illness NN cord-347946-i6kx3n6m 476 1 Meta Meta NNP cord-347946-i6kx3n6m 476 2 - - HYPH cord-347946-i6kx3n6m 476 3 analysis analysis NN cord-347946-i6kx3n6m 476 4 of of IN cord-347946-i6kx3n6m 476 5 cytokines cytokine NNS cord-347946-i6kx3n6m 476 6 and and CC cord-347946-i6kx3n6m 476 7 chemokines chemokine NNS cord-347946-i6kx3n6m 476 8 in in IN cord-347946-i6kx3n6m 476 9 suicidality suicidality NN cord-347946-i6kx3n6m 476 10 : : : cord-347946-i6kx3n6m 477 1 distinguishing distinguish VBG cord-347946-i6kx3n6m 477 2 suicidal suicidal JJ cord-347946-i6kx3n6m 477 3 versus versus IN cord-347946-i6kx3n6m 477 4 nonsuicidal nonsuicidal JJ cord-347946-i6kx3n6m 477 5 patients patient NNS cord-347946-i6kx3n6m 477 6 Epidemiology Epidemiology NNP cord-347946-i6kx3n6m 477 7 of of IN cord-347946-i6kx3n6m 477 8 major major JJ cord-347946-i6kx3n6m 477 9 depression depression NN cord-347946-i6kx3n6m 477 10 with with IN cord-347946-i6kx3n6m 477 11 atypical atypical JJ cord-347946-i6kx3n6m 477 12 features feature NNS cord-347946-i6kx3n6m 477 13 : : : cord-347946-i6kx3n6m 477 14 results result NNS cord-347946-i6kx3n6m 477 15 from from IN cord-347946-i6kx3n6m 477 16 the the DT cord-347946-i6kx3n6m 477 17 National National NNP cord-347946-i6kx3n6m 477 18 Epidemiologic Epidemiologic NNP cord-347946-i6kx3n6m 477 19 Survey Survey NNP cord-347946-i6kx3n6m 477 20 on on IN cord-347946-i6kx3n6m 477 21 Alcohol Alcohol NNP cord-347946-i6kx3n6m 477 22 and and CC cord-347946-i6kx3n6m 477 23 Related Related NNP cord-347946-i6kx3n6m 477 24 Conditions condition NNS cord-347946-i6kx3n6m 477 25 ( ( -LRB- cord-347946-i6kx3n6m 477 26 NESARC NESARC NNP cord-347946-i6kx3n6m 477 27 ) ) -RRB- cord-347946-i6kx3n6m 478 1 Immune immune JJ cord-347946-i6kx3n6m 478 2 suppression suppression NN cord-347946-i6kx3n6m 478 3 and and CC cord-347946-i6kx3n6m 478 4 immune immune JJ cord-347946-i6kx3n6m 478 5 activation activation NN cord-347946-i6kx3n6m 478 6 in in IN cord-347946-i6kx3n6m 478 7 depression depression NN cord-347946-i6kx3n6m 479 1 The the DT cord-347946-i6kx3n6m 479 2 risk risk NN cord-347946-i6kx3n6m 479 3 of of IN cord-347946-i6kx3n6m 479 4 new new JJ cord-347946-i6kx3n6m 479 5 onset onset NN cord-347946-i6kx3n6m 479 6 depression depression NN cord-347946-i6kx3n6m 479 7 in in IN cord-347946-i6kx3n6m 479 8 association association NN cord-347946-i6kx3n6m 479 9 with with IN cord-347946-i6kx3n6m 479 10 influenza influenza NN cord-347946-i6kx3n6m 479 11 -A -A : cord-347946-i6kx3n6m 479 12 population population NN cord-347946-i6kx3n6m 479 13 - - HYPH cord-347946-i6kx3n6m 479 14 based base VBN cord-347946-i6kx3n6m 479 15 observational observational JJ cord-347946-i6kx3n6m 479 16 study study NN cord-347946-i6kx3n6m 479 17 Reappraising reappraise VBG cord-347946-i6kx3n6m 479 18 the the DT cord-347946-i6kx3n6m 479 19 relationship relationship NN cord-347946-i6kx3n6m 479 20 between between IN cord-347946-i6kx3n6m 479 21 maternal maternal JJ cord-347946-i6kx3n6m 479 22 age age NN cord-347946-i6kx3n6m 479 23 and and CC cord-347946-i6kx3n6m 479 24 postpartum postpartum NN cord-347946-i6kx3n6m 479 25 depression depression NN cord-347946-i6kx3n6m 479 26 according accord VBG cord-347946-i6kx3n6m 479 27 to to IN cord-347946-i6kx3n6m 479 28 the the DT cord-347946-i6kx3n6m 479 29 evolutionary evolutionary JJ cord-347946-i6kx3n6m 479 30 theory theory NN cord-347946-i6kx3n6m 479 31 : : : cord-347946-i6kx3n6m 479 32 Empirical empirical JJ cord-347946-i6kx3n6m 479 33 evidence evidence NN cord-347946-i6kx3n6m 479 34 from from IN cord-347946-i6kx3n6m 479 35 a a DT cord-347946-i6kx3n6m 479 36 survey survey NN cord-347946-i6kx3n6m 479 37 in in IN cord-347946-i6kx3n6m 479 38 primary primary JJ cord-347946-i6kx3n6m 479 39 health health NN cord-347946-i6kx3n6m 479 40 services service NNS cord-347946-i6kx3n6m 479 41 Leptin Leptin NNP cord-347946-i6kx3n6m 479 42 levels level NNS cord-347946-i6kx3n6m 479 43 in in IN cord-347946-i6kx3n6m 479 44 various various JJ cord-347946-i6kx3n6m 479 45 manifestations manifestation NNS cord-347946-i6kx3n6m 479 46 of of IN cord-347946-i6kx3n6m 479 47 pulmonary pulmonary JJ cord-347946-i6kx3n6m 479 48 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 479 49 Depression depression NN cord-347946-i6kx3n6m 479 50 , , , cord-347946-i6kx3n6m 479 51 immunocompetence immunocompetence NN cord-347946-i6kx3n6m 479 52 , , , cord-347946-i6kx3n6m 479 53 and and CC cord-347946-i6kx3n6m 479 54 prostaglandins prostaglandin NNS cord-347946-i6kx3n6m 479 55 of of IN cord-347946-i6kx3n6m 479 56 the the DT cord-347946-i6kx3n6m 479 57 E E NNP cord-347946-i6kx3n6m 479 58 series series NN cord-347946-i6kx3n6m 480 1 Does do VBZ cord-347946-i6kx3n6m 480 2 cytokine cytokine NN cord-347946-i6kx3n6m 480 3 - - HYPH cord-347946-i6kx3n6m 480 4 induced induce VBN cord-347946-i6kx3n6m 480 5 depression depression NN cord-347946-i6kx3n6m 480 6 differ differ VBP cord-347946-i6kx3n6m 480 7 from from IN cord-347946-i6kx3n6m 480 8 idiopathic idiopathic JJ cord-347946-i6kx3n6m 480 9 major major JJ cord-347946-i6kx3n6m 480 10 depression depression NN cord-347946-i6kx3n6m 480 11 in in IN cord-347946-i6kx3n6m 480 12 medically medically RB cord-347946-i6kx3n6m 480 13 healthy healthy JJ cord-347946-i6kx3n6m 480 14 individuals individual NNS cord-347946-i6kx3n6m 480 15 ? ? . cord-347946-i6kx3n6m 481 1 Neurobehavioral Neurobehavioral NNP cord-347946-i6kx3n6m 481 2 effects effect NNS cord-347946-i6kx3n6m 481 3 of of IN cord-347946-i6kx3n6m 481 4 interferon interferon NN cord-347946-i6kx3n6m 481 5 - - HYPH cord-347946-i6kx3n6m 481 6 alpha alpha NN cord-347946-i6kx3n6m 481 7 in in IN cord-347946-i6kx3n6m 481 8 cancer cancer NN cord-347946-i6kx3n6m 481 9 patients patient NNS cord-347946-i6kx3n6m 481 10 : : : cord-347946-i6kx3n6m 481 11 phenomenology phenomenology NN cord-347946-i6kx3n6m 481 12 and and CC cord-347946-i6kx3n6m 481 13 paroxetine paroxetine NN cord-347946-i6kx3n6m 481 14 responsiveness responsiveness NN cord-347946-i6kx3n6m 481 15 of of IN cord-347946-i6kx3n6m 481 16 symptom symptom NN cord-347946-i6kx3n6m 481 17 dimensions dimension NNS cord-347946-i6kx3n6m 482 1 Interferon interferon NN cord-347946-i6kx3n6m 482 2 - - HYPH cord-347946-i6kx3n6m 482 3 alpha alpha NN cord-347946-i6kx3n6m 482 4 - - HYPH cord-347946-i6kx3n6m 482 5 induced induce VBN cord-347946-i6kx3n6m 482 6 changes change NNS cord-347946-i6kx3n6m 482 7 in in IN cord-347946-i6kx3n6m 482 8 tryptophan tryptophan NN cord-347946-i6kx3n6m 482 9 metabolism metabolism NN cord-347946-i6kx3n6m 482 10 . . . cord-347946-i6kx3n6m 483 1 relationship relationship NN cord-347946-i6kx3n6m 483 2 to to IN cord-347946-i6kx3n6m 483 3 depression depression NN cord-347946-i6kx3n6m 483 4 and and CC cord-347946-i6kx3n6m 483 5 paroxetine paroxetine NN cord-347946-i6kx3n6m 483 6 treatment treatment NN cord-347946-i6kx3n6m 483 7 Anterior Anterior NNP cord-347946-i6kx3n6m 483 8 cingulate cingulate NN cord-347946-i6kx3n6m 483 9 activation activation NN cord-347946-i6kx3n6m 483 10 and and CC cord-347946-i6kx3n6m 483 11 error error NN cord-347946-i6kx3n6m 483 12 processing processing NN cord-347946-i6kx3n6m 483 13 during during IN cord-347946-i6kx3n6m 483 14 interferon interferon NN cord-347946-i6kx3n6m 483 15 - - HYPH cord-347946-i6kx3n6m 483 16 alpha alpha NN cord-347946-i6kx3n6m 483 17 treatment treatment NN cord-347946-i6kx3n6m 483 18 Basal Basal NNP cord-347946-i6kx3n6m 483 19 ganglia ganglia VBZ cord-347946-i6kx3n6m 483 20 hypermetabolism hypermetabolism NN cord-347946-i6kx3n6m 483 21 and and CC cord-347946-i6kx3n6m 483 22 symptoms symptom NNS cord-347946-i6kx3n6m 483 23 of of IN cord-347946-i6kx3n6m 483 24 fatigue fatigue NN cord-347946-i6kx3n6m 483 25 during during IN cord-347946-i6kx3n6m 483 26 interferon interferon NN cord-347946-i6kx3n6m 483 27 - - HYPH cord-347946-i6kx3n6m 483 28 alpha alpha NN cord-347946-i6kx3n6m 483 29 therapy therapy NNP cord-347946-i6kx3n6m 483 30 Association Association NNP cord-347946-i6kx3n6m 483 31 of of IN cord-347946-i6kx3n6m 483 32 exaggerated exaggerated JJ cord-347946-i6kx3n6m 483 33 HPA HPA NNP cord-347946-i6kx3n6m 483 34 axis axis NN cord-347946-i6kx3n6m 483 35 response response NN cord-347946-i6kx3n6m 483 36 to to IN cord-347946-i6kx3n6m 483 37 the the DT cord-347946-i6kx3n6m 483 38 initial initial JJ cord-347946-i6kx3n6m 483 39 injection injection NN cord-347946-i6kx3n6m 483 40 of of IN cord-347946-i6kx3n6m 483 41 interferon interferon NN cord-347946-i6kx3n6m 483 42 - - HYPH cord-347946-i6kx3n6m 483 43 alpha alpha NN cord-347946-i6kx3n6m 483 44 with with IN cord-347946-i6kx3n6m 483 45 development development NN cord-347946-i6kx3n6m 483 46 of of IN cord-347946-i6kx3n6m 483 47 depression depression NN cord-347946-i6kx3n6m 483 48 during during IN cord-347946-i6kx3n6m 483 49 interferon interferon NN cord-347946-i6kx3n6m 483 50 - - HYPH cord-347946-i6kx3n6m 483 51 alpha alpha NN cord-347946-i6kx3n6m 483 52 therapy therapy NN cord-347946-i6kx3n6m 484 1 IFNG IFNG NNP cord-347946-i6kx3n6m 484 2 +874 +874 NNP cord-347946-i6kx3n6m 485 1 T4A t4a CD cord-347946-i6kx3n6m 485 2 single single JJ cord-347946-i6kx3n6m 485 3 nucleotide nucleotide JJ cord-347946-i6kx3n6m 485 4 polymorphism polymorphism NN cord-347946-i6kx3n6m 485 5 is be VBZ cord-347946-i6kx3n6m 485 6 associated associate VBN cord-347946-i6kx3n6m 485 7 with with IN cord-347946-i6kx3n6m 485 8 leprosy leprosy NN cord-347946-i6kx3n6m 485 9 among among IN cord-347946-i6kx3n6m 485 10 Brazilians Brazilians NNPS cord-347946-i6kx3n6m 485 11 Association Association NNP cord-347946-i6kx3n6m 485 12 between between IN cord-347946-i6kx3n6m 485 13 plasma plasma NN cord-347946-i6kx3n6m 485 14 IL-6 IL-6 NNP cord-347946-i6kx3n6m 485 15 response response NN cord-347946-i6kx3n6m 485 16 to to IN cord-347946-i6kx3n6m 485 17 acute acute JJ cord-347946-i6kx3n6m 485 18 stress stress NN cord-347946-i6kx3n6m 485 19 and and CC cord-347946-i6kx3n6m 485 20 early early JJ cord-347946-i6kx3n6m 485 21 - - HYPH cord-347946-i6kx3n6m 485 22 life life NN cord-347946-i6kx3n6m 485 23 adversity adversity NN cord-347946-i6kx3n6m 485 24 in in IN cord-347946-i6kx3n6m 485 25 healthy healthy JJ cord-347946-i6kx3n6m 485 26 adults adult NNS cord-347946-i6kx3n6m 486 1 Gender gender NN cord-347946-i6kx3n6m 486 2 differences difference NNS cord-347946-i6kx3n6m 486 3 in in IN cord-347946-i6kx3n6m 486 4 the the DT cord-347946-i6kx3n6m 486 5 presentation presentation NN cord-347946-i6kx3n6m 486 6 of of IN cord-347946-i6kx3n6m 486 7 depressed depressed JJ cord-347946-i6kx3n6m 486 8 outpatients outpatient NNS cord-347946-i6kx3n6m 486 9 : : : cord-347946-i6kx3n6m 487 1 a a DT cord-347946-i6kx3n6m 487 2 comparison comparison NN cord-347946-i6kx3n6m 487 3 of of IN cord-347946-i6kx3n6m 487 4 descriptive descriptive JJ cord-347946-i6kx3n6m 487 5 variables variable NNS cord-347946-i6kx3n6m 487 6 Reduced reduce VBN cord-347946-i6kx3n6m 487 7 levels level NNS cord-347946-i6kx3n6m 487 8 of of IN cord-347946-i6kx3n6m 487 9 transforming transform VBG cord-347946-i6kx3n6m 487 10 growth growth NN cord-347946-i6kx3n6m 487 11 factor factor NN cord-347946-i6kx3n6m 487 12 - - HYPH cord-347946-i6kx3n6m 487 13 beta1 beta1 NN cord-347946-i6kx3n6m 487 14 , , , cord-347946-i6kx3n6m 487 15 interleukin-12 interleukin-12 NN cord-347946-i6kx3n6m 487 16 and and CC cord-347946-i6kx3n6m 487 17 increased increase VBN cord-347946-i6kx3n6m 487 18 migration migration NN cord-347946-i6kx3n6m 487 19 inhibitory inhibitory JJ cord-347946-i6kx3n6m 487 20 factor factor NN cord-347946-i6kx3n6m 487 21 are be VBP cord-347946-i6kx3n6m 487 22 associated associate VBN cord-347946-i6kx3n6m 487 23 with with IN cord-347946-i6kx3n6m 487 24 severe severe JJ cord-347946-i6kx3n6m 487 25 malaria malaria NN cord-347946-i6kx3n6m 488 1 The the DT cord-347946-i6kx3n6m 488 2 effect effect NN cord-347946-i6kx3n6m 488 3 of of IN cord-347946-i6kx3n6m 488 4 psychological psychological JJ cord-347946-i6kx3n6m 488 5 stress stress NN cord-347946-i6kx3n6m 488 6 on on IN cord-347946-i6kx3n6m 488 7 iron iron NN cord-347946-i6kx3n6m 488 8 absorption absorption NN cord-347946-i6kx3n6m 488 9 in in IN cord-347946-i6kx3n6m 488 10 rats rat NNS cord-347946-i6kx3n6m 489 1 The the DT cord-347946-i6kx3n6m 489 2 interferon interferon NN cord-347946-i6kx3n6m 489 3 gamma gamma NN cord-347946-i6kx3n6m 489 4 gene gene NN cord-347946-i6kx3n6m 489 5 polymorphism polymorphism NN cord-347946-i6kx3n6m 490 1 +874 +874 NNP cord-347946-i6kx3n6m 490 2 A A NNP cord-347946-i6kx3n6m 490 3 / / SYM cord-347946-i6kx3n6m 490 4 T T NNP cord-347946-i6kx3n6m 490 5 is be VBZ cord-347946-i6kx3n6m 490 6 associated associate VBN cord-347946-i6kx3n6m 490 7 with with IN cord-347946-i6kx3n6m 490 8 severe severe JJ cord-347946-i6kx3n6m 490 9 acute acute JJ cord-347946-i6kx3n6m 490 10 respiratory respiratory JJ cord-347946-i6kx3n6m 490 11 syndrome syndrome NN cord-347946-i6kx3n6m 491 1 A a DT cord-347946-i6kx3n6m 491 2 beta3-adrenergic beta3-adrenergic JJ cord-347946-i6kx3n6m 491 3 - - HYPH cord-347946-i6kx3n6m 491 4 leptin leptin NN cord-347946-i6kx3n6m 491 5 - - HYPH cord-347946-i6kx3n6m 491 6 melanocortin melanocortin NNP cord-347946-i6kx3n6m 491 7 circuit circuit NN cord-347946-i6kx3n6m 491 8 regulates regulate VBZ cord-347946-i6kx3n6m 491 9 behavioral behavioral JJ cord-347946-i6kx3n6m 491 10 and and CC cord-347946-i6kx3n6m 491 11 metabolic metabolic JJ cord-347946-i6kx3n6m 491 12 changes change NNS cord-347946-i6kx3n6m 491 13 induced induce VBN cord-347946-i6kx3n6m 491 14 by by IN cord-347946-i6kx3n6m 491 15 chronic chronic JJ cord-347946-i6kx3n6m 491 16 stress stress NN cord-347946-i6kx3n6m 491 17 Low Low NNP cord-347946-i6kx3n6m 491 18 24-hour 24-hour JJ cord-347946-i6kx3n6m 491 19 adiponectin adiponectin NN cord-347946-i6kx3n6m 491 20 and and CC cord-347946-i6kx3n6m 491 21 high high JJ cord-347946-i6kx3n6m 491 22 nocturnal nocturnal JJ cord-347946-i6kx3n6m 491 23 leptin leptin NN cord-347946-i6kx3n6m 491 24 concentrations concentration NNS cord-347946-i6kx3n6m 491 25 in in IN cord-347946-i6kx3n6m 491 26 a a DT cord-347946-i6kx3n6m 491 27 case case NN cord-347946-i6kx3n6m 491 28 - - HYPH cord-347946-i6kx3n6m 491 29 control control NN cord-347946-i6kx3n6m 491 30 study study NN cord-347946-i6kx3n6m 491 31 of of IN cord-347946-i6kx3n6m 491 32 community community NN cord-347946-i6kx3n6m 491 33 - - HYPH cord-347946-i6kx3n6m 491 34 dwelling dwell VBG cord-347946-i6kx3n6m 491 35 premenopausal premenopausal JJ cord-347946-i6kx3n6m 491 36 women woman NNS cord-347946-i6kx3n6m 491 37 with with IN cord-347946-i6kx3n6m 491 38 major major JJ cord-347946-i6kx3n6m 491 39 depressive depressive JJ cord-347946-i6kx3n6m 491 40 disorder disorder NN cord-347946-i6kx3n6m 491 41 : : : cord-347946-i6kx3n6m 492 1 the the DT cord-347946-i6kx3n6m 492 2 Premenopausal Premenopausal NNP cord-347946-i6kx3n6m 492 3 , , , cord-347946-i6kx3n6m 492 4 Osteopenia Osteopenia NNP cord-347946-i6kx3n6m 492 5 / / SYM cord-347946-i6kx3n6m 492 6 Osteoporosis osteoporosis NN cord-347946-i6kx3n6m 492 7 , , , cord-347946-i6kx3n6m 492 8 Women Women NNPS cord-347946-i6kx3n6m 492 9 , , , cord-347946-i6kx3n6m 492 10 Alendronate Alendronate NNP cord-347946-i6kx3n6m 492 11 , , , cord-347946-i6kx3n6m 492 12 Depression Depression NNP cord-347946-i6kx3n6m 492 13 ( ( -LRB- cord-347946-i6kx3n6m 492 14 POWER POWER NNP cord-347946-i6kx3n6m 492 15 ) ) -RRB- cord-347946-i6kx3n6m 492 16 study study NN cord-347946-i6kx3n6m 492 17 What what WP cord-347946-i6kx3n6m 492 18 does do VBZ cord-347946-i6kx3n6m 492 19 tumour tumour NN cord-347946-i6kx3n6m 492 20 necrosis necrosis NN cord-347946-i6kx3n6m 492 21 factor factor NN cord-347946-i6kx3n6m 492 22 excess excess JJ cord-347946-i6kx3n6m 492 23 do do VBP cord-347946-i6kx3n6m 492 24 to to IN cord-347946-i6kx3n6m 492 25 the the DT cord-347946-i6kx3n6m 492 26 immune immune JJ cord-347946-i6kx3n6m 492 27 system system NN cord-347946-i6kx3n6m 492 28 long long JJ cord-347946-i6kx3n6m 492 29 term term NN cord-347946-i6kx3n6m 492 30 Infectious infectious JJ cord-347946-i6kx3n6m 492 31 causation causation NN cord-347946-i6kx3n6m 492 32 of of IN cord-347946-i6kx3n6m 492 33 disease disease NN cord-347946-i6kx3n6m 492 34 : : : cord-347946-i6kx3n6m 492 35 an an DT cord-347946-i6kx3n6m 492 36 evolutionary evolutionary JJ cord-347946-i6kx3n6m 492 37 perspective perspective NN cord-347946-i6kx3n6m 493 1 Sparse sparse JJ cord-347946-i6kx3n6m 493 2 whole whole JJ cord-347946-i6kx3n6m 493 3 - - HYPH cord-347946-i6kx3n6m 493 4 genome genome NN cord-347946-i6kx3n6m 493 5 sequencing sequencing NN cord-347946-i6kx3n6m 493 6 identifies identify VBZ cord-347946-i6kx3n6m 493 7 two two CD cord-347946-i6kx3n6m 493 8 loci locus NNS cord-347946-i6kx3n6m 493 9 for for IN cord-347946-i6kx3n6m 493 10 major major JJ cord-347946-i6kx3n6m 493 11 depressive depressive JJ cord-347946-i6kx3n6m 493 12 disorder disorder NN cord-347946-i6kx3n6m 493 13 Mood Mood NNP cord-347946-i6kx3n6m 493 14 alterations alteration NNS cord-347946-i6kx3n6m 493 15 during during IN cord-347946-i6kx3n6m 493 16 interferon interferon NN cord-347946-i6kx3n6m 493 17 - - HYPH cord-347946-i6kx3n6m 493 18 alfa alfa NNP cord-347946-i6kx3n6m 493 19 therapy therapy NN cord-347946-i6kx3n6m 493 20 in in IN cord-347946-i6kx3n6m 493 21 patients patient NNS cord-347946-i6kx3n6m 493 22 with with IN cord-347946-i6kx3n6m 493 23 chronic chronic JJ cord-347946-i6kx3n6m 493 24 hepatitis hepatitis NN cord-347946-i6kx3n6m 493 25 C c NN cord-347946-i6kx3n6m 493 26 : : : cord-347946-i6kx3n6m 493 27 evidence evidence NN cord-347946-i6kx3n6m 493 28 for for IN cord-347946-i6kx3n6m 493 29 an an DT cord-347946-i6kx3n6m 493 30 overlap overlap NN cord-347946-i6kx3n6m 493 31 between between IN cord-347946-i6kx3n6m 493 32 manic manic JJ cord-347946-i6kx3n6m 493 33 / / , cord-347946-i6kx3n6m 493 34 hypomanic hypomanic JJ cord-347946-i6kx3n6m 493 35 and and CC cord-347946-i6kx3n6m 493 36 depressive depressive JJ cord-347946-i6kx3n6m 493 37 symptoms symptom NNS cord-347946-i6kx3n6m 493 38 Exploring explore VBG cord-347946-i6kx3n6m 493 39 the the DT cord-347946-i6kx3n6m 493 40 reciprocal reciprocal JJ cord-347946-i6kx3n6m 493 41 relationship relationship NN cord-347946-i6kx3n6m 493 42 between between IN cord-347946-i6kx3n6m 493 43 immunity immunity NN cord-347946-i6kx3n6m 493 44 and and CC cord-347946-i6kx3n6m 493 45 inflammation inflammation NN cord-347946-i6kx3n6m 493 46 in in IN cord-347946-i6kx3n6m 493 47 chronic chronic JJ cord-347946-i6kx3n6m 493 48 inflammatory inflammatory JJ cord-347946-i6kx3n6m 493 49 arthritis arthritis NN cord-347946-i6kx3n6m 493 50 Chronic Chronic NNP cord-347946-i6kx3n6m 493 51 tumor tumor NN cord-347946-i6kx3n6m 493 52 necrosis necrosis NN cord-347946-i6kx3n6m 493 53 factor factor NN cord-347946-i6kx3n6m 493 54 alters alter VBZ cord-347946-i6kx3n6m 493 55 T T NNP cord-347946-i6kx3n6m 493 56 cell cell NN cord-347946-i6kx3n6m 493 57 responses response NNS cord-347946-i6kx3n6m 493 58 by by IN cord-347946-i6kx3n6m 493 59 attenuating attenuate VBG cord-347946-i6kx3n6m 493 60 T T NNP cord-347946-i6kx3n6m 493 61 cell cell NN cord-347946-i6kx3n6m 493 62 receptor receptor NN cord-347946-i6kx3n6m 493 63 signaling signal VBG cord-347946-i6kx3n6m 493 64 High high JJ cord-347946-i6kx3n6m 493 65 interleukin-10 interleukin-10 NN cord-347946-i6kx3n6m 493 66 production production NN cord-347946-i6kx3n6m 493 67 is be VBZ cord-347946-i6kx3n6m 493 68 associated associate VBN cord-347946-i6kx3n6m 493 69 with with IN cord-347946-i6kx3n6m 493 70 low low JJ cord-347946-i6kx3n6m 493 71 antibody antibody NN cord-347946-i6kx3n6m 493 72 response response NN cord-347946-i6kx3n6m 493 73 to to IN cord-347946-i6kx3n6m 493 74 influenza influenza NN cord-347946-i6kx3n6m 493 75 vaccination vaccination NN cord-347946-i6kx3n6m 493 76 in in IN cord-347946-i6kx3n6m 493 77 the the DT cord-347946-i6kx3n6m 493 78 elderly elderly JJ cord-347946-i6kx3n6m 493 79 Depression Depression NNP cord-347946-i6kx3n6m 493 80 and and CC cord-347946-i6kx3n6m 493 81 HIV HIV NNP cord-347946-i6kx3n6m 493 82 infection infection NN cord-347946-i6kx3n6m 493 83 : : : cord-347946-i6kx3n6m 493 84 impact impact NN cord-347946-i6kx3n6m 493 85 on on IN cord-347946-i6kx3n6m 493 86 immune immune JJ cord-347946-i6kx3n6m 493 87 function function NN cord-347946-i6kx3n6m 493 88 and and CC cord-347946-i6kx3n6m 493 89 disease disease NN cord-347946-i6kx3n6m 493 90 progression progression NN cord-347946-i6kx3n6m 493 91 Prenatal prenatal JJ cord-347946-i6kx3n6m 493 92 cytokine cytokine NN cord-347946-i6kx3n6m 493 93 exposure exposure NN cord-347946-i6kx3n6m 493 94 results result NNS cord-347946-i6kx3n6m 493 95 in in IN cord-347946-i6kx3n6m 493 96 obesity obesity NN cord-347946-i6kx3n6m 493 97 and and CC cord-347946-i6kx3n6m 493 98 gender gender NN cord-347946-i6kx3n6m 493 99 - - HYPH cord-347946-i6kx3n6m 493 100 specific specific JJ cord-347946-i6kx3n6m 493 101 programming programming NN cord-347946-i6kx3n6m 493 102 Cytokine cytokine NN cord-347946-i6kx3n6m 493 103 , , , cord-347946-i6kx3n6m 493 104 sickness sickness NN cord-347946-i6kx3n6m 493 105 behavior behavior NN cord-347946-i6kx3n6m 493 106 , , , cord-347946-i6kx3n6m 493 107 and and CC cord-347946-i6kx3n6m 493 108 depression depression NN cord-347946-i6kx3n6m 493 109 From from IN cord-347946-i6kx3n6m 493 110 inflammation inflammation NN cord-347946-i6kx3n6m 493 111 to to IN cord-347946-i6kx3n6m 493 112 sickness sickness NN cord-347946-i6kx3n6m 493 113 and and CC cord-347946-i6kx3n6m 493 114 depression depression NN cord-347946-i6kx3n6m 493 115 : : : cord-347946-i6kx3n6m 493 116 when when WRB cord-347946-i6kx3n6m 493 117 the the DT cord-347946-i6kx3n6m 493 118 immune immune JJ cord-347946-i6kx3n6m 493 119 system system NN cord-347946-i6kx3n6m 493 120 subjugates subjugate VBZ cord-347946-i6kx3n6m 493 121 the the DT cord-347946-i6kx3n6m 493 122 brain brain NN cord-347946-i6kx3n6m 493 123 From from IN cord-347946-i6kx3n6m 493 124 inflammation inflammation NN cord-347946-i6kx3n6m 493 125 to to IN cord-347946-i6kx3n6m 493 126 sickness sickness NN cord-347946-i6kx3n6m 493 127 and and CC cord-347946-i6kx3n6m 493 128 depression depression NN cord-347946-i6kx3n6m 493 129 : : : cord-347946-i6kx3n6m 493 130 when when WRB cord-347946-i6kx3n6m 493 131 the the DT cord-347946-i6kx3n6m 493 132 immune immune JJ cord-347946-i6kx3n6m 493 133 system system NN cord-347946-i6kx3n6m 493 134 subjugates subjugate VBZ cord-347946-i6kx3n6m 493 135 the the DT cord-347946-i6kx3n6m 493 136 brain brain NN cord-347946-i6kx3n6m 493 137 Synergistic synergistic JJ cord-347946-i6kx3n6m 493 138 effect effect NN cord-347946-i6kx3n6m 493 139 in in IN cord-347946-i6kx3n6m 493 140 viral viral JJ cord-347946-i6kx3n6m 493 141 - - HYPH cord-347946-i6kx3n6m 493 142 bacterial bacterial JJ cord-347946-i6kx3n6m 493 143 infection infection NN cord-347946-i6kx3n6m 493 144 . . . cord-347946-i6kx3n6m 494 1 I. I. NNP cord-347946-i6kx3n6m 494 2 Combined combined JJ cord-347946-i6kx3n6m 494 3 infection infection NN cord-347946-i6kx3n6m 494 4 of of IN cord-347946-i6kx3n6m 494 5 the the DT cord-347946-i6kx3n6m 494 6 respiratory respiratory JJ cord-347946-i6kx3n6m 494 7 tract tract NN cord-347946-i6kx3n6m 494 8 in in IN cord-347946-i6kx3n6m 494 9 mice mouse NNS cord-347946-i6kx3n6m 494 10 with with IN cord-347946-i6kx3n6m 494 11 parainfluenza parainfluenza NNP cord-347946-i6kx3n6m 494 12 virus virus NN cord-347946-i6kx3n6m 494 13 and and CC cord-347946-i6kx3n6m 494 14 Hemophilus Hemophilus NNP cord-347946-i6kx3n6m 494 15 influenza influenza NN cord-347946-i6kx3n6m 494 16 Enhancing enhance VBG cord-347946-i6kx3n6m 494 17 versus versus IN cord-347946-i6kx3n6m 494 18 suppressive suppressive JJ cord-347946-i6kx3n6m 494 19 effects effect NNS cord-347946-i6kx3n6m 494 20 of of IN cord-347946-i6kx3n6m 494 21 stress stress NN cord-347946-i6kx3n6m 494 22 on on IN cord-347946-i6kx3n6m 494 23 immune immune JJ cord-347946-i6kx3n6m 494 24 function function NN cord-347946-i6kx3n6m 494 25 : : : cord-347946-i6kx3n6m 494 26 implications implication NNS cord-347946-i6kx3n6m 494 27 for for IN cord-347946-i6kx3n6m 494 28 immunoprotection immunoprotection NN cord-347946-i6kx3n6m 494 29 and and CC cord-347946-i6kx3n6m 494 30 immunopathology immunopathology NN cord-347946-i6kx3n6m 494 31 Wound Wound NNP cord-347946-i6kx3n6m 494 32 healing healing NN cord-347946-i6kx3n6m 494 33 : : : cord-347946-i6kx3n6m 494 34 the the DT cord-347946-i6kx3n6m 494 35 role role NN cord-347946-i6kx3n6m 494 36 of of IN cord-347946-i6kx3n6m 494 37 the the DT cord-347946-i6kx3n6m 494 38 macrophage macrophage NN cord-347946-i6kx3n6m 494 39 and and CC cord-347946-i6kx3n6m 494 40 other other JJ cord-347946-i6kx3n6m 494 41 immune immune JJ cord-347946-i6kx3n6m 494 42 cells cell NNS cord-347946-i6kx3n6m 494 43 Relation relation NN cord-347946-i6kx3n6m 494 44 of of IN cord-347946-i6kx3n6m 494 45 depression depression NN cord-347946-i6kx3n6m 494 46 , , , cord-347946-i6kx3n6m 494 47 natural natural JJ cord-347946-i6kx3n6m 494 48 killer killer NN cord-347946-i6kx3n6m 494 49 cell cell NN cord-347946-i6kx3n6m 494 50 function function NN cord-347946-i6kx3n6m 494 51 , , , cord-347946-i6kx3n6m 494 52 and and CC cord-347946-i6kx3n6m 494 53 infections infection NNS cord-347946-i6kx3n6m 494 54 after after IN cord-347946-i6kx3n6m 494 55 coronary coronary JJ cord-347946-i6kx3n6m 494 56 artery artery NN cord-347946-i6kx3n6m 494 57 bypass bypass NN cord-347946-i6kx3n6m 494 58 in in IN cord-347946-i6kx3n6m 494 59 women woman NNS cord-347946-i6kx3n6m 494 60 Repeated repeat VBD cord-347946-i6kx3n6m 494 61 social social JJ cord-347946-i6kx3n6m 494 62 stress stress NN cord-347946-i6kx3n6m 494 63 enhances enhance VBZ cord-347946-i6kx3n6m 494 64 the the DT cord-347946-i6kx3n6m 494 65 innate innate JJ cord-347946-i6kx3n6m 494 66 immune immune JJ cord-347946-i6kx3n6m 494 67 response response NN cord-347946-i6kx3n6m 494 68 to to IN cord-347946-i6kx3n6m 494 69 a a DT cord-347946-i6kx3n6m 494 70 primary primary JJ cord-347946-i6kx3n6m 494 71 HSV-1 HSV-1 NNP cord-347946-i6kx3n6m 494 72 infection infection NN cord-347946-i6kx3n6m 494 73 in in IN cord-347946-i6kx3n6m 494 74 the the DT cord-347946-i6kx3n6m 494 75 cornea cornea NN cord-347946-i6kx3n6m 494 76 and and CC cord-347946-i6kx3n6m 494 77 trigeminal trigeminal JJ cord-347946-i6kx3n6m 494 78 ganglia ganglion NNS cord-347946-i6kx3n6m 494 79 of of IN cord-347946-i6kx3n6m 494 80 Balb Balb NNP cord-347946-i6kx3n6m 494 81 / / SYM cord-347946-i6kx3n6m 494 82 c c NN cord-347946-i6kx3n6m 494 83 mice mouse NNS cord-347946-i6kx3n6m 494 84 Frequency frequency NN cord-347946-i6kx3n6m 494 85 of of IN cord-347946-i6kx3n6m 494 86 infection infection NN cord-347946-i6kx3n6m 494 87 in in IN cord-347946-i6kx3n6m 494 88 patients patient NNS cord-347946-i6kx3n6m 494 89 with with IN cord-347946-i6kx3n6m 494 90 rheumatoid rheumatoid NN cord-347946-i6kx3n6m 494 91 arthritis arthritis NN cord-347946-i6kx3n6m 494 92 compared compare VBN cord-347946-i6kx3n6m 494 93 with with IN cord-347946-i6kx3n6m 494 94 controls control NNS cord-347946-i6kx3n6m 494 95 : : : cord-347946-i6kx3n6m 494 96 a a DT cord-347946-i6kx3n6m 494 97 population population NN cord-347946-i6kx3n6m 494 98 - - HYPH cord-347946-i6kx3n6m 494 99 based base VBN cord-347946-i6kx3n6m 494 100 study study NN cord-347946-i6kx3n6m 495 1 A a DT cord-347946-i6kx3n6m 495 2 metaanalysis metaanalysis NN cord-347946-i6kx3n6m 495 3 of of IN cord-347946-i6kx3n6m 495 4 cytokines cytokine NNS cord-347946-i6kx3n6m 495 5 in in IN cord-347946-i6kx3n6m 495 6 major major JJ cord-347946-i6kx3n6m 495 7 depression depression NN cord-347946-i6kx3n6m 495 8 Trade Trade NNP cord-347946-i6kx3n6m 495 9 - - HYPH cord-347946-i6kx3n6m 495 10 off off RP cord-347946-i6kx3n6m 495 11 mediated mediate VBN cord-347946-i6kx3n6m 495 12 effects effect NNS cord-347946-i6kx3n6m 495 13 on on IN cord-347946-i6kx3n6m 495 14 the the DT cord-347946-i6kx3n6m 495 15 genetics genetic NNS cord-347946-i6kx3n6m 495 16 of of IN cord-347946-i6kx3n6m 495 17 human human JJ cord-347946-i6kx3n6m 495 18 survival survival NN cord-347946-i6kx3n6m 495 19 caused cause VBN cord-347946-i6kx3n6m 495 20 by by IN cord-347946-i6kx3n6m 495 21 increasingly increasingly RB cord-347946-i6kx3n6m 495 22 benign benign JJ cord-347946-i6kx3n6m 495 23 living living NN cord-347946-i6kx3n6m 495 24 conditions condition NNS cord-347946-i6kx3n6m 495 25 Differential Differential NNP cord-347946-i6kx3n6m 495 26 association association NNP cord-347946-i6kx3n6m 495 27 of of IN cord-347946-i6kx3n6m 495 28 somatic somatic JJ cord-347946-i6kx3n6m 495 29 and and CC cord-347946-i6kx3n6m 495 30 cognitive cognitive JJ cord-347946-i6kx3n6m 495 31 symptoms symptom NNS cord-347946-i6kx3n6m 495 32 of of IN cord-347946-i6kx3n6m 495 33 depression depression NN cord-347946-i6kx3n6m 495 34 and and CC cord-347946-i6kx3n6m 495 35 anxiety anxiety NN cord-347946-i6kx3n6m 495 36 with with IN cord-347946-i6kx3n6m 495 37 inflammation inflammation NN cord-347946-i6kx3n6m 495 38 : : : cord-347946-i6kx3n6m 495 39 findings finding NNS cord-347946-i6kx3n6m 495 40 from from IN cord-347946-i6kx3n6m 495 41 the the DT cord-347946-i6kx3n6m 495 42 Netherlands Netherlands NNP cord-347946-i6kx3n6m 495 43 Study Study NNP cord-347946-i6kx3n6m 495 44 of of IN cord-347946-i6kx3n6m 495 45 Depression Depression NNP cord-347946-i6kx3n6m 495 46 and and CC cord-347946-i6kx3n6m 495 47 Anxiety Anxiety NNP cord-347946-i6kx3n6m 495 48 ( ( -LRB- cord-347946-i6kx3n6m 495 49 NESDA NESDA NNP cord-347946-i6kx3n6m 495 50 ) ) -RRB- cord-347946-i6kx3n6m 496 1 Natural natural JJ cord-347946-i6kx3n6m 496 2 history history NN cord-347946-i6kx3n6m 496 3 of of IN cord-347946-i6kx3n6m 496 4 Diagnostic Diagnostic NNP cord-347946-i6kx3n6m 496 5 Interview Interview NNP cord-347946-i6kx3n6m 496 6 Schedule Schedule NNP cord-347946-i6kx3n6m 496 7 / / SYM cord-347946-i6kx3n6m 496 8 DSM DSM NNP cord-347946-i6kx3n6m 496 9 - - HYPH cord-347946-i6kx3n6m 496 10 IV IV NNP cord-347946-i6kx3n6m 496 11 major major JJ cord-347946-i6kx3n6m 496 12 depression depression NN cord-347946-i6kx3n6m 496 13 . . . cord-347946-i6kx3n6m 497 1 The the DT cord-347946-i6kx3n6m 497 2 Baltimore Baltimore NNP cord-347946-i6kx3n6m 497 3 Epidemiologic Epidemiologic NNP cord-347946-i6kx3n6m 497 4 Catchment Catchment NNP cord-347946-i6kx3n6m 497 5 Area Area NNP cord-347946-i6kx3n6m 497 6 follow follow NN cord-347946-i6kx3n6m 497 7 - - HYPH cord-347946-i6kx3n6m 497 8 up up RP cord-347946-i6kx3n6m 497 9 Inflammation inflammation NN cord-347946-i6kx3n6m 497 10 - - HYPH cord-347946-i6kx3n6m 497 11 induced induce VBN cord-347946-i6kx3n6m 497 12 anhedonia anhedonia NN cord-347946-i6kx3n6m 497 13 : : : cord-347946-i6kx3n6m 497 14 endotoxin endotoxin NN cord-347946-i6kx3n6m 497 15 reduces reduce VBZ cord-347946-i6kx3n6m 497 16 ventral ventral JJ cord-347946-i6kx3n6m 497 17 striatum striatum JJ cord-347946-i6kx3n6m 497 18 responses response NNS cord-347946-i6kx3n6m 497 19 to to TO cord-347946-i6kx3n6m 497 20 reward reward VB cord-347946-i6kx3n6m 497 21 Inflammation inflammation NN cord-347946-i6kx3n6m 497 22 and and CC cord-347946-i6kx3n6m 497 23 social social JJ cord-347946-i6kx3n6m 497 24 experience experience NN cord-347946-i6kx3n6m 497 25 : : : cord-347946-i6kx3n6m 497 26 an an DT cord-347946-i6kx3n6m 497 27 inflammatory inflammatory JJ cord-347946-i6kx3n6m 497 28 challenge challenge NN cord-347946-i6kx3n6m 497 29 induces induce VBZ cord-347946-i6kx3n6m 497 30 feelings feeling NNS cord-347946-i6kx3n6m 497 31 of of IN cord-347946-i6kx3n6m 497 32 social social JJ cord-347946-i6kx3n6m 497 33 disconnection disconnection NN cord-347946-i6kx3n6m 497 34 in in IN cord-347946-i6kx3n6m 497 35 addition addition NN cord-347946-i6kx3n6m 497 36 to to IN cord-347946-i6kx3n6m 497 37 depressed depressed JJ cord-347946-i6kx3n6m 497 38 mood mood NN cord-347946-i6kx3n6m 498 1 The the DT cord-347946-i6kx3n6m 498 2 association association NN cord-347946-i6kx3n6m 498 3 between between IN cord-347946-i6kx3n6m 498 4 children child NNS cord-347946-i6kx3n6m 498 5 's 's POS cord-347946-i6kx3n6m 498 6 sleep sleep NN cord-347946-i6kx3n6m 498 7 disruption disruption NN cord-347946-i6kx3n6m 498 8 and and CC cord-347946-i6kx3n6m 498 9 salivary salivary NN cord-347946-i6kx3n6m 498 10 interleukin-6 interleukin-6 NNP cord-347946-i6kx3n6m 498 11 Decreased decrease VBD cord-347946-i6kx3n6m 498 12 CD3+CD16 CD3+CD16 NNP cord-347946-i6kx3n6m 498 13 + + CC cord-347946-i6kx3n6m 498 14 natural natural JJ cord-347946-i6kx3n6m 498 15 killer killer NN cord-347946-i6kx3n6m 498 16 - - HYPH cord-347946-i6kx3n6m 498 17 like like JJ cord-347946-i6kx3n6m 498 18 T t NN cord-347946-i6kx3n6m 498 19 - - HYPH cord-347946-i6kx3n6m 498 20 cell cell NN cord-347946-i6kx3n6m 498 21 percentage percentage NN cord-347946-i6kx3n6m 498 22 and and CC cord-347946-i6kx3n6m 498 23 zeta zeta JJ cord-347946-i6kx3n6m 498 24 - - HYPH cord-347946-i6kx3n6m 498 25 chain chain NN cord-347946-i6kx3n6m 498 26 expression expression NN cord-347946-i6kx3n6m 498 27 accompany accompany VBP cord-347946-i6kx3n6m 498 28 chronic chronic JJ cord-347946-i6kx3n6m 498 29 inflammation inflammation NN cord-347946-i6kx3n6m 498 30 in in IN cord-347946-i6kx3n6m 498 31 haemodialysis haemodialysis NNP cord-347946-i6kx3n6m 498 32 patients patient NNS cord-347946-i6kx3n6m 498 33 Conservation conservation NN cord-347946-i6kx3n6m 498 34 - - HYPH cord-347946-i6kx3n6m 498 35 withdrawal withdrawal NN cord-347946-i6kx3n6m 498 36 : : : cord-347946-i6kx3n6m 499 1 a a DT cord-347946-i6kx3n6m 499 2 primary primary JJ cord-347946-i6kx3n6m 499 3 regulatory regulatory JJ cord-347946-i6kx3n6m 499 4 process process NN cord-347946-i6kx3n6m 499 5 for for IN cord-347946-i6kx3n6m 499 6 organismic organismic JJ cord-347946-i6kx3n6m 499 7 homeostasis homeostasis NN cord-347946-i6kx3n6m 499 8 Men man NNS cord-347946-i6kx3n6m 499 9 and and CC cord-347946-i6kx3n6m 499 10 women woman NNS cord-347946-i6kx3n6m 499 11 differ differ VBP cord-347946-i6kx3n6m 499 12 in in IN cord-347946-i6kx3n6m 499 13 inflammatory inflammatory JJ cord-347946-i6kx3n6m 499 14 and and CC cord-347946-i6kx3n6m 499 15 neuroendocrine neuroendocrine JJ cord-347946-i6kx3n6m 499 16 responses response NNS cord-347946-i6kx3n6m 499 17 to to IN cord-347946-i6kx3n6m 499 18 endotoxin endotoxin NN cord-347946-i6kx3n6m 499 19 but but CC cord-347946-i6kx3n6m 499 20 not not RB cord-347946-i6kx3n6m 499 21 in in IN cord-347946-i6kx3n6m 499 22 the the DT cord-347946-i6kx3n6m 499 23 severity severity NN cord-347946-i6kx3n6m 499 24 of of IN cord-347946-i6kx3n6m 499 25 sickness sickness NN cord-347946-i6kx3n6m 499 26 symptoms symptom NNS cord-347946-i6kx3n6m 499 27 Brain Brain NNP cord-347946-i6kx3n6m 499 28 function function VBP cord-347946-i6kx3n6m 499 29 in in IN cord-347946-i6kx3n6m 499 30 carriers carrier NNS cord-347946-i6kx3n6m 499 31 of of IN cord-347946-i6kx3n6m 499 32 a a DT cord-347946-i6kx3n6m 499 33 genome genome NN cord-347946-i6kx3n6m 499 34 - - HYPH cord-347946-i6kx3n6m 499 35 wide wide JJ cord-347946-i6kx3n6m 499 36 supported support VBN cord-347946-i6kx3n6m 499 37 bipolar bipolar JJ cord-347946-i6kx3n6m 499 38 disorder disorder NN cord-347946-i6kx3n6m 499 39 variant variant NN cord-347946-i6kx3n6m 499 40 Paleopathology Paleopathology NNP cord-347946-i6kx3n6m 499 41 and and CC cord-347946-i6kx3n6m 499 42 the the DT cord-347946-i6kx3n6m 499 43 origin origin NN cord-347946-i6kx3n6m 499 44 of of IN cord-347946-i6kx3n6m 499 45 agriculture agriculture NN cord-347946-i6kx3n6m 499 46 in in IN cord-347946-i6kx3n6m 499 47 the the DT cord-347946-i6kx3n6m 499 48 Levant Levant NNP cord-347946-i6kx3n6m 499 49 Association Association NNP cord-347946-i6kx3n6m 499 50 of of IN cord-347946-i6kx3n6m 499 51 depression depression NN cord-347946-i6kx3n6m 499 52 with with IN cord-347946-i6kx3n6m 499 53 viral viral JJ cord-347946-i6kx3n6m 499 54 load load NN cord-347946-i6kx3n6m 499 55 , , , cord-347946-i6kx3n6m 499 56 CD8 CD8 NNP cord-347946-i6kx3n6m 499 57 T T NNP cord-347946-i6kx3n6m 499 58 lymphocytes lymphocyte NNS cord-347946-i6kx3n6m 499 59 , , , cord-347946-i6kx3n6m 499 60 and and CC cord-347946-i6kx3n6m 499 61 natural natural JJ cord-347946-i6kx3n6m 499 62 killer killer NN cord-347946-i6kx3n6m 499 63 cells cell NNS cord-347946-i6kx3n6m 499 64 in in IN cord-347946-i6kx3n6m 499 65 women woman NNS cord-347946-i6kx3n6m 499 66 with with IN cord-347946-i6kx3n6m 499 67 HIV HIV NNP cord-347946-i6kx3n6m 499 68 infection infection NN cord-347946-i6kx3n6m 499 69 A a DT cord-347946-i6kx3n6m 499 70 metaanalysis metaanalysis NN cord-347946-i6kx3n6m 499 71 of of IN cord-347946-i6kx3n6m 499 72 chemokines chemokine NNS cord-347946-i6kx3n6m 499 73 in in IN cord-347946-i6kx3n6m 499 74 major major JJ cord-347946-i6kx3n6m 499 75 depression depression NN cord-347946-i6kx3n6m 499 76 A a DT cord-347946-i6kx3n6m 499 77 longitudinal longitudinal JJ cord-347946-i6kx3n6m 499 78 study study NN cord-347946-i6kx3n6m 499 79 of of IN cord-347946-i6kx3n6m 499 80 the the DT cord-347946-i6kx3n6m 499 81 relationship relationship NN cord-347946-i6kx3n6m 499 82 between between IN cord-347946-i6kx3n6m 499 83 psychological psychological JJ cord-347946-i6kx3n6m 499 84 distress distress NN cord-347946-i6kx3n6m 499 85 and and CC cord-347946-i6kx3n6m 499 86 recurrence recurrence NN cord-347946-i6kx3n6m 499 87 of of IN cord-347946-i6kx3n6m 499 88 upper upper JJ cord-347946-i6kx3n6m 499 89 respiratory respiratory JJ cord-347946-i6kx3n6m 499 90 tract tract NN cord-347946-i6kx3n6m 499 91 infections infection NNS cord-347946-i6kx3n6m 499 92 in in IN cord-347946-i6kx3n6m 499 93 chronic chronic JJ cord-347946-i6kx3n6m 499 94 fatigue fatigue NN cord-347946-i6kx3n6m 499 95 syndrome syndrome NN cord-347946-i6kx3n6m 499 96 Early early JJ cord-347946-i6kx3n6m 499 97 activation activation NN cord-347946-i6kx3n6m 499 98 of of IN cord-347946-i6kx3n6m 499 99 p38 p38 CD cord-347946-i6kx3n6m 499 100 mitogen mitogen NNP cord-347946-i6kx3n6m 499 101 activated activate VBN cord-347946-i6kx3n6m 499 102 protein protein NN cord-347946-i6kx3n6m 499 103 kinase kinase NN cord-347946-i6kx3n6m 499 104 is be VBZ cord-347946-i6kx3n6m 499 105 associated associate VBN cord-347946-i6kx3n6m 499 106 with with IN cord-347946-i6kx3n6m 499 107 interferonalpha interferonalpha NN cord-347946-i6kx3n6m 499 108 - - HYPH cord-347946-i6kx3n6m 499 109 induced induce VBN cord-347946-i6kx3n6m 499 110 depression depression NN cord-347946-i6kx3n6m 499 111 and and CC cord-347946-i6kx3n6m 499 112 fatigue fatigue NN cord-347946-i6kx3n6m 499 113 Tyrosine tyrosine NN cord-347946-i6kx3n6m 499 114 metabolism metabolism NN cord-347946-i6kx3n6m 499 115 during during IN cord-347946-i6kx3n6m 499 116 interferon interferon NN cord-347946-i6kx3n6m 499 117 - - HYPH cord-347946-i6kx3n6m 499 118 alpha alpha NN cord-347946-i6kx3n6m 499 119 administration administration NN cord-347946-i6kx3n6m 499 120 : : : cord-347946-i6kx3n6m 499 121 Association Association NNP cord-347946-i6kx3n6m 499 122 with with IN cord-347946-i6kx3n6m 499 123 fatigue fatigue NN cord-347946-i6kx3n6m 499 124 and and CC cord-347946-i6kx3n6m 499 125 CSF CSF NNP cord-347946-i6kx3n6m 499 126 dopamine dopamine NN cord-347946-i6kx3n6m 499 127 concentrations concentration NNS cord-347946-i6kx3n6m 500 1 Inflammation inflammation NN cord-347946-i6kx3n6m 500 2 is be VBZ cord-347946-i6kx3n6m 500 3 associated associate VBN cord-347946-i6kx3n6m 500 4 with with IN cord-347946-i6kx3n6m 500 5 decreased decrease VBN cord-347946-i6kx3n6m 500 6 functional functional JJ cord-347946-i6kx3n6m 500 7 connectivity connectivity NN cord-347946-i6kx3n6m 500 8 within within IN cord-347946-i6kx3n6m 500 9 corticostriatal corticostriatal JJ cord-347946-i6kx3n6m 500 10 reward reward NN cord-347946-i6kx3n6m 500 11 circuitry circuitry NN cord-347946-i6kx3n6m 500 12 in in IN cord-347946-i6kx3n6m 500 13 depression depression NN cord-347946-i6kx3n6m 500 14 Regulation regulation NN cord-347946-i6kx3n6m 500 15 of of IN cord-347946-i6kx3n6m 500 16 PGC-1alpha pgc-1alpha NN cord-347946-i6kx3n6m 500 17 , , , cord-347946-i6kx3n6m 500 18 a a DT cord-347946-i6kx3n6m 500 19 nodal nodal JJ cord-347946-i6kx3n6m 500 20 regulator regulator NN cord-347946-i6kx3n6m 500 21 of of IN cord-347946-i6kx3n6m 500 22 mitochondrial mitochondrial JJ cord-347946-i6kx3n6m 500 23 biogenesis biogenesis NN cord-347946-i6kx3n6m 500 24 Pathogen Pathogen NNP cord-347946-i6kx3n6m 500 25 prevalence prevalence NN cord-347946-i6kx3n6m 500 26 predicts predict VBZ cord-347946-i6kx3n6m 500 27 human human JJ cord-347946-i6kx3n6m 500 28 cross cross JJ cord-347946-i6kx3n6m 500 29 - - JJ cord-347946-i6kx3n6m 500 30 cultural cultural JJ cord-347946-i6kx3n6m 500 31 variability variability NN cord-347946-i6kx3n6m 500 32 in in IN cord-347946-i6kx3n6m 500 33 individualism individualism NN cord-347946-i6kx3n6m 500 34 / / SYM cord-347946-i6kx3n6m 500 35 collectivism collectivism NN cord-347946-i6kx3n6m 500 36 Depression depression NN cord-347946-i6kx3n6m 500 37 in in IN cord-347946-i6kx3n6m 500 38 older old JJR cord-347946-i6kx3n6m 500 39 adults adult NNS cord-347946-i6kx3n6m 500 40 Relevance relevance NN cord-347946-i6kx3n6m 500 41 of of IN cord-347946-i6kx3n6m 500 42 gamma gamma NN cord-347946-i6kx3n6m 500 43 interferon interferon NN cord-347946-i6kx3n6m 500 44 , , , cord-347946-i6kx3n6m 500 45 tumor tumor NN cord-347946-i6kx3n6m 500 46 necrosis necrosis NN cord-347946-i6kx3n6m 500 47 factor factor NN cord-347946-i6kx3n6m 500 48 alpha alpha NN cord-347946-i6kx3n6m 500 49 , , , cord-347946-i6kx3n6m 500 50 and and CC cord-347946-i6kx3n6m 500 51 interleukin-10 interleukin-10 NN cord-347946-i6kx3n6m 500 52 gene gene NN cord-347946-i6kx3n6m 500 53 polymorphisms polymorphism NNS cord-347946-i6kx3n6m 500 54 to to IN cord-347946-i6kx3n6m 500 55 susceptibility susceptibility NN cord-347946-i6kx3n6m 500 56 to to IN cord-347946-i6kx3n6m 500 57 Mediterranean Mediterranean NNP cord-347946-i6kx3n6m 500 58 spotted spot VBD cord-347946-i6kx3n6m 500 59 fever fever NN cord-347946-i6kx3n6m 500 60 Dynamic dynamic JJ cord-347946-i6kx3n6m 500 61 spread spread NN cord-347946-i6kx3n6m 500 62 of of IN cord-347946-i6kx3n6m 500 63 happiness happiness NN cord-347946-i6kx3n6m 500 64 in in IN cord-347946-i6kx3n6m 500 65 a a DT cord-347946-i6kx3n6m 500 66 large large JJ cord-347946-i6kx3n6m 500 67 social social JJ cord-347946-i6kx3n6m 500 68 network network NN cord-347946-i6kx3n6m 500 69 : : : cord-347946-i6kx3n6m 501 1 longitudinal longitudinal JJ cord-347946-i6kx3n6m 501 2 analysis analysis NN cord-347946-i6kx3n6m 501 3 over over IN cord-347946-i6kx3n6m 501 4 20 20 CD cord-347946-i6kx3n6m 501 5 years year NNS cord-347946-i6kx3n6m 501 6 in in IN cord-347946-i6kx3n6m 501 7 the the DT cord-347946-i6kx3n6m 501 8 Framingham Framingham NNP cord-347946-i6kx3n6m 501 9 Heart Heart NNP cord-347946-i6kx3n6m 501 10 Study Study NNP cord-347946-i6kx3n6m 501 11 Poor poor JJ cord-347946-i6kx3n6m 501 12 sleep sleep NN cord-347946-i6kx3n6m 501 13 quality quality NN cord-347946-i6kx3n6m 501 14 predicts predict VBZ cord-347946-i6kx3n6m 501 15 onset onset NN cord-347946-i6kx3n6m 501 16 of of IN cord-347946-i6kx3n6m 501 17 either either DT cord-347946-i6kx3n6m 501 18 major major JJ cord-347946-i6kx3n6m 501 19 depression depression NN cord-347946-i6kx3n6m 501 20 or or CC cord-347946-i6kx3n6m 501 21 subsyndromal subsyndromal NNP cord-347946-i6kx3n6m 501 22 depression depression NN cord-347946-i6kx3n6m 501 23 with with IN cord-347946-i6kx3n6m 501 24 irritability irritability NN cord-347946-i6kx3n6m 501 25 during during IN cord-347946-i6kx3n6m 501 26 interferon interferon NN cord-347946-i6kx3n6m 501 27 - - HYPH cord-347946-i6kx3n6m 501 28 alpha alpha NN cord-347946-i6kx3n6m 501 29 treatment treatment NN cord-347946-i6kx3n6m 501 30 Association Association NNP cord-347946-i6kx3n6m 501 31 of of IN cord-347946-i6kx3n6m 501 32 IL-10 IL-10 NNP cord-347946-i6kx3n6m 501 33 polymorphism polymorphism NN cord-347946-i6kx3n6m 501 34 with with IN cord-347946-i6kx3n6m 501 35 severity severity NN cord-347946-i6kx3n6m 501 36 of of IN cord-347946-i6kx3n6m 501 37 illness illness NN cord-347946-i6kx3n6m 501 38 in in IN cord-347946-i6kx3n6m 501 39 community community NN cord-347946-i6kx3n6m 501 40 acquired acquire VBD cord-347946-i6kx3n6m 501 41 pneumonia pneumonia NN cord-347946-i6kx3n6m 501 42 Polymorphisms Polymorphisms NNPS cord-347946-i6kx3n6m 501 43 of of IN cord-347946-i6kx3n6m 501 44 some some DT cord-347946-i6kx3n6m 501 45 cytokines cytokine NNS cord-347946-i6kx3n6m 501 46 and and CC cord-347946-i6kx3n6m 501 47 chronic chronic JJ cord-347946-i6kx3n6m 501 48 hepatitis hepatitis NN cord-347946-i6kx3n6m 501 49 B B NNP cord-347946-i6kx3n6m 501 50 and and CC cord-347946-i6kx3n6m 501 51 C C NNP cord-347946-i6kx3n6m 501 52 virus virus NN cord-347946-i6kx3n6m 501 53 infection infection NN cord-347946-i6kx3n6m 501 54 High high JJ cord-347946-i6kx3n6m 501 55 serum serum NN cord-347946-i6kx3n6m 501 56 leptin leptin NN cord-347946-i6kx3n6m 501 57 levels level NNS cord-347946-i6kx3n6m 501 58 in in IN cord-347946-i6kx3n6m 501 59 depressive depressive JJ cord-347946-i6kx3n6m 501 60 disorders disorder NNS cord-347946-i6kx3n6m 501 61 with with IN cord-347946-i6kx3n6m 501 62 atypical atypical JJ cord-347946-i6kx3n6m 501 63 features feature NNS cord-347946-i6kx3n6m 502 1 A a DT cord-347946-i6kx3n6m 502 2 longitudinal longitudinal JJ cord-347946-i6kx3n6m 502 3 study study NN cord-347946-i6kx3n6m 502 4 of of IN cord-347946-i6kx3n6m 502 5 maternal maternal JJ cord-347946-i6kx3n6m 502 6 depression depression NN cord-347946-i6kx3n6m 502 7 and and CC cord-347946-i6kx3n6m 502 8 child child NN cord-347946-i6kx3n6m 502 9 behaviour behaviour NN cord-347946-i6kx3n6m 502 10 problems problem NNS cord-347946-i6kx3n6m 502 11 Medical medical JJ cord-347946-i6kx3n6m 502 12 comorbidity comorbidity NN cord-347946-i6kx3n6m 502 13 in in IN cord-347946-i6kx3n6m 502 14 recurrent recurrent JJ cord-347946-i6kx3n6m 502 15 versus versus IN cord-347946-i6kx3n6m 502 16 first first JJ cord-347946-i6kx3n6m 502 17 - - HYPH cord-347946-i6kx3n6m 502 18 episode episode NN cord-347946-i6kx3n6m 502 19 depressive depressive JJ cord-347946-i6kx3n6m 502 20 patients patient NNS cord-347946-i6kx3n6m 503 1 Inflammatory inflammatory JJ cord-347946-i6kx3n6m 503 2 markers marker NNS cord-347946-i6kx3n6m 503 3 are be VBP cord-347946-i6kx3n6m 503 4 associated associate VBN cord-347946-i6kx3n6m 503 5 wtih wtih NN cord-347946-i6kx3n6m 503 6 decreased decrease VBD cord-347946-i6kx3n6m 503 7 psychomotor psychomotor JJ cord-347946-i6kx3n6m 503 8 speed speed NN cord-347946-i6kx3n6m 503 9 in in IN cord-347946-i6kx3n6m 503 10 patients patient NNS cord-347946-i6kx3n6m 503 11 with with IN cord-347946-i6kx3n6m 503 12 major major JJ cord-347946-i6kx3n6m 503 13 depressive depressive JJ cord-347946-i6kx3n6m 503 14 disorder disorder NN cord-347946-i6kx3n6m 504 1 A a DT cord-347946-i6kx3n6m 504 2 meta meta JJ cord-347946-i6kx3n6m 504 3 - - HYPH cord-347946-i6kx3n6m 504 4 analysis analysis NN cord-347946-i6kx3n6m 504 5 of of IN cord-347946-i6kx3n6m 504 6 blood blood NN cord-347946-i6kx3n6m 504 7 cytokine cytokine NN cord-347946-i6kx3n6m 504 8 network network NN cord-347946-i6kx3n6m 504 9 alterations alteration NNS cord-347946-i6kx3n6m 504 10 in in IN cord-347946-i6kx3n6m 504 11 psychiatric psychiatric JJ cord-347946-i6kx3n6m 504 12 patients patient NNS cord-347946-i6kx3n6m 504 13 : : : cord-347946-i6kx3n6m 504 14 comparisons comparison NNS cord-347946-i6kx3n6m 504 15 between between IN cord-347946-i6kx3n6m 504 16 schizophrenia schizophrenia NN cord-347946-i6kx3n6m 504 17 , , , cord-347946-i6kx3n6m 504 18 bipolar bipolar JJ cord-347946-i6kx3n6m 504 19 disorder disorder NN cord-347946-i6kx3n6m 504 20 and and CC cord-347946-i6kx3n6m 504 21 depression depression NN cord-347946-i6kx3n6m 504 22 . . . cord-347946-i6kx3n6m 505 1 Mol Mol NNP cord-347946-i6kx3n6m 505 2 Psychiatry Psychiatry NNP cord-347946-i6kx3n6m 505 3 ; ; : cord-347946-i6kx3n6m 505 4 e e LS cord-347946-i6kx3n6m 505 5 - - NN cord-347946-i6kx3n6m 505 6 pub pub JJ cord-347946-i6kx3n6m 505 7 ahead ahead RB cord-347946-i6kx3n6m 505 8 of of IN cord-347946-i6kx3n6m 505 9 print print NN cord-347946-i6kx3n6m 505 10 Inflammation inflammation NN cord-347946-i6kx3n6m 505 11 and and CC cord-347946-i6kx3n6m 505 12 the the DT cord-347946-i6kx3n6m 505 13 phenomenology phenomenology NN cord-347946-i6kx3n6m 505 14 , , , cord-347946-i6kx3n6m 505 15 pathophysiology pathophysiology NN cord-347946-i6kx3n6m 505 16 , , , cord-347946-i6kx3n6m 505 17 comorbidity comorbidity NN cord-347946-i6kx3n6m 505 18 , , , cord-347946-i6kx3n6m 505 19 and and CC cord-347946-i6kx3n6m 505 20 treatment treatment NN cord-347946-i6kx3n6m 505 21 of of IN cord-347946-i6kx3n6m 505 22 bipolar bipolar JJ cord-347946-i6kx3n6m 505 23 disorder disorder NN cord-347946-i6kx3n6m 505 24 : : : cord-347946-i6kx3n6m 505 25 a a DT cord-347946-i6kx3n6m 505 26 systematic systematic JJ cord-347946-i6kx3n6m 505 27 review review NN cord-347946-i6kx3n6m 505 28 of of IN cord-347946-i6kx3n6m 505 29 the the DT cord-347946-i6kx3n6m 505 30 literature literature NN cord-347946-i6kx3n6m 505 31 Interleukin-1 Interleukin-1 NNP cord-347946-i6kx3n6m 505 32 ( ( -LRB- cord-347946-i6kx3n6m 505 33 IL-1 IL-1 NNP cord-347946-i6kx3n6m 505 34 ) ) -RRB- cord-347946-i6kx3n6m 505 35 : : : cord-347946-i6kx3n6m 505 36 a a DT cord-347946-i6kx3n6m 505 37 central central JJ cord-347946-i6kx3n6m 505 38 regulator regulator NN cord-347946-i6kx3n6m 505 39 of of IN cord-347946-i6kx3n6m 505 40 stress stress NN cord-347946-i6kx3n6m 505 41 responses response NNS cord-347946-i6kx3n6m 505 42 Mood Mood NNP cord-347946-i6kx3n6m 505 43 disturbance disturbance NN cord-347946-i6kx3n6m 505 44 after after IN cord-347946-i6kx3n6m 505 45 infection infection NN cord-347946-i6kx3n6m 506 1 Cumulative cumulative JJ cord-347946-i6kx3n6m 506 2 meta meta NN cord-347946-i6kx3n6m 506 3 - - HYPH cord-347946-i6kx3n6m 506 4 analysis analysis NN cord-347946-i6kx3n6m 506 5 of of IN cord-347946-i6kx3n6m 506 6 interleukins interleukin NNS cord-347946-i6kx3n6m 506 7 6 6 CD cord-347946-i6kx3n6m 506 8 and and CC cord-347946-i6kx3n6m 506 9 1beta 1beta CD cord-347946-i6kx3n6m 506 10 , , , cord-347946-i6kx3n6m 506 11 tumour tumour NN cord-347946-i6kx3n6m 506 12 necrosis necrosis NN cord-347946-i6kx3n6m 506 13 factor factor NN cord-347946-i6kx3n6m 506 14 alpha alpha NN cord-347946-i6kx3n6m 506 15 and and CC cord-347946-i6kx3n6m 506 16 C C NNP cord-347946-i6kx3n6m 506 17 - - HYPH cord-347946-i6kx3n6m 506 18 reactive reactive JJ cord-347946-i6kx3n6m 506 19 protein protein NN cord-347946-i6kx3n6m 506 20 in in IN cord-347946-i6kx3n6m 506 21 patients patient NNS cord-347946-i6kx3n6m 506 22 with with IN cord-347946-i6kx3n6m 506 23 major major JJ cord-347946-i6kx3n6m 506 24 depressive depressive JJ cord-347946-i6kx3n6m 506 25 disorder disorder NN cord-347946-i6kx3n6m 507 1 The the DT cord-347946-i6kx3n6m 507 2 functions function NNS cord-347946-i6kx3n6m 507 3 of of IN cord-347946-i6kx3n6m 507 4 postpartum postpartum NN cord-347946-i6kx3n6m 507 5 depression depression NN cord-347946-i6kx3n6m 507 6 Perinatal perinatal JJ cord-347946-i6kx3n6m 507 7 sadness sadness NN cord-347946-i6kx3n6m 507 8 among among IN cord-347946-i6kx3n6m 507 9 Shuar Shuar NNP cord-347946-i6kx3n6m 507 10 women woman NNS cord-347946-i6kx3n6m 507 11 : : : cord-347946-i6kx3n6m 507 12 support support VB cord-347946-i6kx3n6m 507 13 for for IN cord-347946-i6kx3n6m 507 14 an an DT cord-347946-i6kx3n6m 507 15 evolutionary evolutionary JJ cord-347946-i6kx3n6m 507 16 theory theory NN cord-347946-i6kx3n6m 507 17 of of IN cord-347946-i6kx3n6m 507 18 psychic psychic JJ cord-347946-i6kx3n6m 507 19 pain pain NN cord-347946-i6kx3n6m 507 20 Maternal maternal JJ cord-347946-i6kx3n6m 507 21 depression depression NN cord-347946-i6kx3n6m 507 22 and and CC cord-347946-i6kx3n6m 507 23 psychiatric psychiatric JJ cord-347946-i6kx3n6m 507 24 outcomes outcome NNS cord-347946-i6kx3n6m 507 25 in in IN cord-347946-i6kx3n6m 507 26 adolescent adolescent JJ cord-347946-i6kx3n6m 507 27 offspring offspring NN cord-347946-i6kx3n6m 507 28 : : : cord-347946-i6kx3n6m 508 1 a a DT cord-347946-i6kx3n6m 508 2 13-year 13-year JJ cord-347946-i6kx3n6m 508 3 longitudinal longitudinal JJ cord-347946-i6kx3n6m 508 4 study study NN cord-347946-i6kx3n6m 508 5 Being be VBG cord-347946-i6kx3n6m 508 6 popular popular JJ cord-347946-i6kx3n6m 508 7 can can MD cord-347946-i6kx3n6m 508 8 be be VB cord-347946-i6kx3n6m 508 9 healthy healthy JJ cord-347946-i6kx3n6m 508 10 or or CC cord-347946-i6kx3n6m 508 11 unhealthy unhealthy JJ cord-347946-i6kx3n6m 508 12 : : : cord-347946-i6kx3n6m 508 13 stress stress NN cord-347946-i6kx3n6m 508 14 , , , cord-347946-i6kx3n6m 508 15 social social JJ cord-347946-i6kx3n6m 508 16 network network NN cord-347946-i6kx3n6m 508 17 diversity diversity NN cord-347946-i6kx3n6m 508 18 , , , cord-347946-i6kx3n6m 508 19 and and CC cord-347946-i6kx3n6m 508 20 incidence incidence NN cord-347946-i6kx3n6m 508 21 of of IN cord-347946-i6kx3n6m 508 22 upper upper JJ cord-347946-i6kx3n6m 508 23 respiratory respiratory JJ cord-347946-i6kx3n6m 508 24 infection infection NN cord-347946-i6kx3n6m 508 25 Biochemical biochemical JJ cord-347946-i6kx3n6m 508 26 and and CC cord-347946-i6kx3n6m 508 27 anatomical anatomical JJ cord-347946-i6kx3n6m 508 28 substrates substrate NNS cord-347946-i6kx3n6m 508 29 of of IN cord-347946-i6kx3n6m 508 30 depression depression NN cord-347946-i6kx3n6m 508 31 and and CC cord-347946-i6kx3n6m 508 32 sickness sickness NN cord-347946-i6kx3n6m 508 33 behavior behavior NN cord-347946-i6kx3n6m 509 1 Citalopram Citalopram NNP cord-347946-i6kx3n6m 509 2 reduces reduce VBZ cord-347946-i6kx3n6m 509 3 endotoxin endotoxin NN cord-347946-i6kx3n6m 509 4 - - HYPH cord-347946-i6kx3n6m 509 5 induced induce VBN cord-347946-i6kx3n6m 509 6 fatigue fatigue NN cord-347946-i6kx3n6m 509 7 Enhanced enhance VBN cord-347946-i6kx3n6m 509 8 expression expression NN cord-347946-i6kx3n6m 509 9 and and CC cord-347946-i6kx3n6m 509 10 secretion secretion NN cord-347946-i6kx3n6m 509 11 of of IN cord-347946-i6kx3n6m 509 12 antimicrobial antimicrobial JJ cord-347946-i6kx3n6m 509 13 peptides peptide NNS cord-347946-i6kx3n6m 509 14 in in IN cord-347946-i6kx3n6m 509 15 atopic atopic JJ cord-347946-i6kx3n6m 509 16 dermatitis dermatitis NN cord-347946-i6kx3n6m 509 17 and and CC cord-347946-i6kx3n6m 509 18 after after IN cord-347946-i6kx3n6m 509 19 superficial superficial JJ cord-347946-i6kx3n6m 509 20 skin skin NN cord-347946-i6kx3n6m 509 21 injury injury NN cord-347946-i6kx3n6m 510 1 The the DT cord-347946-i6kx3n6m 510 2 role role NN cord-347946-i6kx3n6m 510 3 and and CC cord-347946-i6kx3n6m 510 4 potential potential JJ cord-347946-i6kx3n6m 510 5 therapeutical therapeutical JJ cord-347946-i6kx3n6m 510 6 applications application NNS cord-347946-i6kx3n6m 510 7 of of IN cord-347946-i6kx3n6m 510 8 antimicrobial antimicrobial JJ cord-347946-i6kx3n6m 510 9 proteins protein NNS cord-347946-i6kx3n6m 510 10 in in IN cord-347946-i6kx3n6m 510 11 infectious infectious JJ cord-347946-i6kx3n6m 510 12 and and CC cord-347946-i6kx3n6m 510 13 inflammatory inflammatory JJ cord-347946-i6kx3n6m 510 14 diseases disease NNS cord-347946-i6kx3n6m 510 15 Psoriatic psoriatic JJ cord-347946-i6kx3n6m 510 16 scales scale NNS cord-347946-i6kx3n6m 510 17 : : : cord-347946-i6kx3n6m 510 18 a a DT cord-347946-i6kx3n6m 510 19 promising promising JJ cord-347946-i6kx3n6m 510 20 source source NN cord-347946-i6kx3n6m 510 21 for for IN cord-347946-i6kx3n6m 510 22 the the DT cord-347946-i6kx3n6m 510 23 isolation isolation NN cord-347946-i6kx3n6m 510 24 of of IN cord-347946-i6kx3n6m 510 25 human human JJ cord-347946-i6kx3n6m 510 26 skin skin NN cord-347946-i6kx3n6m 510 27 - - HYPH cord-347946-i6kx3n6m 510 28 derived derive VBN cord-347946-i6kx3n6m 510 29 antimicrobial antimicrobial JJ cord-347946-i6kx3n6m 510 30 proteins protein NNS cord-347946-i6kx3n6m 511 1 Inflammation inflammation NN cord-347946-i6kx3n6m 511 2 causes cause VBZ cord-347946-i6kx3n6m 511 3 mood mood NN cord-347946-i6kx3n6m 511 4 changes change NNS cord-347946-i6kx3n6m 511 5 through through IN cord-347946-i6kx3n6m 511 6 alterations alteration NNS cord-347946-i6kx3n6m 511 7 in in IN cord-347946-i6kx3n6m 511 8 subgenual subgenual NNP cord-347946-i6kx3n6m 511 9 cingulate cingulate NNP cord-347946-i6kx3n6m 511 10 activity activity NN cord-347946-i6kx3n6m 511 11 and and CC cord-347946-i6kx3n6m 511 12 mesolimbic mesolimbic JJ cord-347946-i6kx3n6m 511 13 connectivity connectivity NN cord-347946-i6kx3n6m 511 14 Neural neural JJ cord-347946-i6kx3n6m 511 15 origins origin NNS cord-347946-i6kx3n6m 511 16 of of IN cord-347946-i6kx3n6m 511 17 human human JJ cord-347946-i6kx3n6m 511 18 sickness sickness NN cord-347946-i6kx3n6m 511 19 in in IN cord-347946-i6kx3n6m 511 20 interoceptive interoceptive JJ cord-347946-i6kx3n6m 511 21 responses response NNS cord-347946-i6kx3n6m 511 22 to to IN cord-347946-i6kx3n6m 511 23 inflammation inflammation NN cord-347946-i6kx3n6m 512 1 Repeated repeat VBN cord-347946-i6kx3n6m 512 2 social social JJ cord-347946-i6kx3n6m 512 3 defeat defeat NN cord-347946-i6kx3n6m 512 4 stress stress NN cord-347946-i6kx3n6m 512 5 induces induce VBZ cord-347946-i6kx3n6m 512 6 chronic chronic JJ cord-347946-i6kx3n6m 512 7 hyperthermia hyperthermia NN cord-347946-i6kx3n6m 512 8 in in IN cord-347946-i6kx3n6m 512 9 rats rat NNS cord-347946-i6kx3n6m 512 10 Breastfed Breastfed NNP cord-347946-i6kx3n6m 512 11 at at IN cord-347946-i6kx3n6m 512 12 tiffany tiffany NNP cord-347946-i6kx3n6m 512 13 's 's POS cord-347946-i6kx3n6m 512 14 Depression depression NN cord-347946-i6kx3n6m 512 15 and and CC cord-347946-i6kx3n6m 512 16 immunity immunity NN cord-347946-i6kx3n6m 512 17 : : : cord-347946-i6kx3n6m 512 18 a a DT cord-347946-i6kx3n6m 512 19 meta meta JJ cord-347946-i6kx3n6m 512 20 - - HYPH cord-347946-i6kx3n6m 512 21 analytic analytic JJ cord-347946-i6kx3n6m 512 22 review review NN cord-347946-i6kx3n6m 512 23 Stress stress NN cord-347946-i6kx3n6m 512 24 and and CC cord-347946-i6kx3n6m 512 25 immunity immunity NN cord-347946-i6kx3n6m 512 26 in in IN cord-347946-i6kx3n6m 512 27 humans human NNS cord-347946-i6kx3n6m 512 28 : : : cord-347946-i6kx3n6m 512 29 a a DT cord-347946-i6kx3n6m 512 30 metaanalytic metaanalytic JJ cord-347946-i6kx3n6m 512 31 review review NN cord-347946-i6kx3n6m 512 32 Stress stress NN cord-347946-i6kx3n6m 512 33 and and CC cord-347946-i6kx3n6m 512 34 immunity immunity NN cord-347946-i6kx3n6m 512 35 in in IN cord-347946-i6kx3n6m 512 36 humans human NNS cord-347946-i6kx3n6m 512 37 : : : cord-347946-i6kx3n6m 512 38 a a DT cord-347946-i6kx3n6m 512 39 metaanalytic metaanalytic JJ cord-347946-i6kx3n6m 512 40 review review NN cord-347946-i6kx3n6m 512 41 A a DT cord-347946-i6kx3n6m 512 42 functional functional JJ cord-347946-i6kx3n6m 512 43 polymorphism polymorphism NN cord-347946-i6kx3n6m 512 44 in in IN cord-347946-i6kx3n6m 512 45 the the DT cord-347946-i6kx3n6m 512 46 IL-10 IL-10 NNP cord-347946-i6kx3n6m 512 47 promoter promoter NN cord-347946-i6kx3n6m 512 48 influences influence VBZ cord-347946-i6kx3n6m 512 49 the the DT cord-347946-i6kx3n6m 512 50 response response NN cord-347946-i6kx3n6m 512 51 after after IN cord-347946-i6kx3n6m 512 52 vaccination vaccination NN cord-347946-i6kx3n6m 512 53 with with IN cord-347946-i6kx3n6m 512 54 HBsAg hbsag ADD cord-347946-i6kx3n6m 512 55 and and CC cord-347946-i6kx3n6m 512 56 hepatitis hepatitis NNP cord-347946-i6kx3n6m 512 57 A A NNP cord-347946-i6kx3n6m 512 58 Associations Associations NNPS cord-347946-i6kx3n6m 512 59 of of IN cord-347946-i6kx3n6m 512 60 depression depression NN cord-347946-i6kx3n6m 512 61 with with IN cord-347946-i6kx3n6m 512 62 C C NNP cord-347946-i6kx3n6m 512 63 - - HYPH cord-347946-i6kx3n6m 512 64 reactive reactive JJ cord-347946-i6kx3n6m 512 65 protein protein NN cord-347946-i6kx3n6m 512 66 , , , cord-347946-i6kx3n6m 512 67 IL-1 IL-1 NNP cord-347946-i6kx3n6m 512 68 , , , cord-347946-i6kx3n6m 512 69 and and CC cord-347946-i6kx3n6m 512 70 IL-6 IL-6 NNP cord-347946-i6kx3n6m 512 71 : : : cord-347946-i6kx3n6m 513 1 a a DT cord-347946-i6kx3n6m 513 2 meta meta JJ cord-347946-i6kx3n6m 513 3 - - HYPH cord-347946-i6kx3n6m 513 4 analysis analysis NN cord-347946-i6kx3n6m 513 5 Antidepressants antidepressant NNS cord-347946-i6kx3n6m 513 6 normalize normalize VBP cord-347946-i6kx3n6m 513 7 elevated elevate VBN cord-347946-i6kx3n6m 513 8 Toll toll NN cord-347946-i6kx3n6m 513 9 - - HYPH cord-347946-i6kx3n6m 513 10 like like JJ cord-347946-i6kx3n6m 513 11 receptor receptor NN cord-347946-i6kx3n6m 513 12 profile profile NN cord-347946-i6kx3n6m 513 13 in in IN cord-347946-i6kx3n6m 513 14 major major JJ cord-347946-i6kx3n6m 513 15 depressive depressive JJ cord-347946-i6kx3n6m 513 16 disorder disorder NN cord-347946-i6kx3n6m 513 17 Association Association NNP cord-347946-i6kx3n6m 513 18 between between IN cord-347946-i6kx3n6m 513 19 toll toll NN cord-347946-i6kx3n6m 513 20 - - HYPH cord-347946-i6kx3n6m 513 21 like like JJ cord-347946-i6kx3n6m 513 22 receptors receptor NNS cord-347946-i6kx3n6m 513 23 expression expression NN cord-347946-i6kx3n6m 513 24 and and CC cord-347946-i6kx3n6m 513 25 major major JJ cord-347946-i6kx3n6m 513 26 depressive depressive JJ cord-347946-i6kx3n6m 513 27 disorder disorder NN cord-347946-i6kx3n6m 514 1 The the DT cord-347946-i6kx3n6m 514 2 role role NN cord-347946-i6kx3n6m 514 3 of of IN cord-347946-i6kx3n6m 514 4 the the DT cord-347946-i6kx3n6m 514 5 ventral ventral JJ cord-347946-i6kx3n6m 514 6 striatum striatum NN cord-347946-i6kx3n6m 514 7 in in IN cord-347946-i6kx3n6m 514 8 inflammatory inflammatory JJ cord-347946-i6kx3n6m 514 9 - - HYPH cord-347946-i6kx3n6m 514 10 induced induce VBN cord-347946-i6kx3n6m 514 11 approach approach NN cord-347946-i6kx3n6m 514 12 toward toward IN cord-347946-i6kx3n6m 514 13 support support NN cord-347946-i6kx3n6m 514 14 figures figure NNS cord-347946-i6kx3n6m 514 15 Reciprocal reciprocal JJ cord-347946-i6kx3n6m 514 16 regulation regulation NN cord-347946-i6kx3n6m 514 17 of of IN cord-347946-i6kx3n6m 514 18 the the DT cord-347946-i6kx3n6m 514 19 neural neural JJ cord-347946-i6kx3n6m 514 20 and and CC cord-347946-i6kx3n6m 514 21 innate innate JJ cord-347946-i6kx3n6m 514 22 immune immune JJ cord-347946-i6kx3n6m 514 23 systems system NNS cord-347946-i6kx3n6m 514 24 Synergistic synergistic JJ cord-347946-i6kx3n6m 514 25 effect effect NN cord-347946-i6kx3n6m 514 26 in in IN cord-347946-i6kx3n6m 514 27 viral viral JJ cord-347946-i6kx3n6m 514 28 - - HYPH cord-347946-i6kx3n6m 514 29 bacterial bacterial JJ cord-347946-i6kx3n6m 514 30 infection infection NN cord-347946-i6kx3n6m 514 31 : : : cord-347946-i6kx3n6m 514 32 combined combine VBN cord-347946-i6kx3n6m 514 33 infection infection NN cord-347946-i6kx3n6m 514 34 of of IN cord-347946-i6kx3n6m 514 35 the the DT cord-347946-i6kx3n6m 514 36 murine murine JJ cord-347946-i6kx3n6m 514 37 respiratory respiratory JJ cord-347946-i6kx3n6m 514 38 tract tract NN cord-347946-i6kx3n6m 514 39 with with IN cord-347946-i6kx3n6m 514 40 Sendai Sendai NNP cord-347946-i6kx3n6m 514 41 virus virus NN cord-347946-i6kx3n6m 514 42 and and CC cord-347946-i6kx3n6m 514 43 Pasteurella Pasteurella NNP cord-347946-i6kx3n6m 514 44 pneumotropica pneumotropica NNP cord-347946-i6kx3n6m 514 45 Oxidative oxidative JJ cord-347946-i6kx3n6m 514 46 stress stress NN cord-347946-i6kx3n6m 514 47 and and CC cord-347946-i6kx3n6m 514 48 antioxidant antioxidant JJ cord-347946-i6kx3n6m 514 49 parameters parameter NNS cord-347946-i6kx3n6m 514 50 in in IN cord-347946-i6kx3n6m 514 51 patients patient NNS cord-347946-i6kx3n6m 514 52 with with IN cord-347946-i6kx3n6m 514 53 major major JJ cord-347946-i6kx3n6m 514 54 depressive depressive JJ cord-347946-i6kx3n6m 514 55 disorder disorder NN cord-347946-i6kx3n6m 514 56 compared compare VBN cord-347946-i6kx3n6m 514 57 to to IN cord-347946-i6kx3n6m 514 58 healthy healthy JJ cord-347946-i6kx3n6m 514 59 controls control NNS cord-347946-i6kx3n6m 514 60 before before RB cord-347946-i6kx3n6m 514 61 and and CC cord-347946-i6kx3n6m 514 62 after after IN cord-347946-i6kx3n6m 514 63 antidepressant antidepressant JJ cord-347946-i6kx3n6m 514 64 treatment treatment NN cord-347946-i6kx3n6m 514 65 : : : cord-347946-i6kx3n6m 514 66 results result NNS cord-347946-i6kx3n6m 514 67 from from IN cord-347946-i6kx3n6m 514 68 a a DT cord-347946-i6kx3n6m 514 69 meta meta JJ cord-347946-i6kx3n6m 514 70 - - HYPH cord-347946-i6kx3n6m 514 71 analysis analysis NN cord-347946-i6kx3n6m 514 72 Stressinduced Stressinduced NNP cord-347946-i6kx3n6m 514 73 neurogenic neurogenic JJ cord-347946-i6kx3n6m 514 74 inflammation inflammation NN cord-347946-i6kx3n6m 514 75 in in IN cord-347946-i6kx3n6m 514 76 murine murine JJ cord-347946-i6kx3n6m 514 77 skin skin NN cord-347946-i6kx3n6m 514 78 skews skew VBZ cord-347946-i6kx3n6m 514 79 dendritic dendritic JJ cord-347946-i6kx3n6m 514 80 cells cell NNS cord-347946-i6kx3n6m 514 81 towards towards IN cord-347946-i6kx3n6m 514 82 maturation maturation NN cord-347946-i6kx3n6m 514 83 and and CC cord-347946-i6kx3n6m 514 84 migration migration NN cord-347946-i6kx3n6m 514 85 : : : cord-347946-i6kx3n6m 514 86 key key JJ cord-347946-i6kx3n6m 514 87 role role NN cord-347946-i6kx3n6m 514 88 of of IN cord-347946-i6kx3n6m 514 89 intercellular intercellular JJ cord-347946-i6kx3n6m 514 90 adhesion adhesion NN cord-347946-i6kx3n6m 514 91 molecule-1 molecule-1 NN cord-347946-i6kx3n6m 514 92 / / SYM cord-347946-i6kx3n6m 514 93 leukocyte leukocyte NN cord-347946-i6kx3n6m 514 94 function function NN cord-347946-i6kx3n6m 514 95 - - HYPH cord-347946-i6kx3n6m 514 96 associated associate VBN cord-347946-i6kx3n6m 514 97 antigen antigen NN cord-347946-i6kx3n6m 514 98 interactions interaction NNS cord-347946-i6kx3n6m 514 99 Inflammation inflammation NN cord-347946-i6kx3n6m 514 100 and and CC cord-347946-i6kx3n6m 514 101 specific specific JJ cord-347946-i6kx3n6m 514 102 symptoms symptom NNS cord-347946-i6kx3n6m 514 103 of of IN cord-347946-i6kx3n6m 514 104 depression depression NN cord-347946-i6kx3n6m 514 105 Lethal lethal JJ cord-347946-i6kx3n6m 514 106 synergism synergism NN cord-347946-i6kx3n6m 514 107 induced induce VBN cord-347946-i6kx3n6m 514 108 in in IN cord-347946-i6kx3n6m 514 109 mice mouse NNS cord-347946-i6kx3n6m 514 110 by by IN cord-347946-i6kx3n6m 514 111 influenza influenza NN cord-347946-i6kx3n6m 514 112 type type NN cord-347946-i6kx3n6m 514 113 A a DT cord-347946-i6kx3n6m 514 114 virus virus NN cord-347946-i6kx3n6m 514 115 and and CC cord-347946-i6kx3n6m 514 116 type type NN cord-347946-i6kx3n6m 514 117 Ia Ia NNP cord-347946-i6kx3n6m 514 118 group group NN cord-347946-i6kx3n6m 514 119 B B NNP cord-347946-i6kx3n6m 514 120 streptococci streptococcus NNS cord-347946-i6kx3n6m 514 121 Endocrine endocrine JJ cord-347946-i6kx3n6m 514 122 and and CC cord-347946-i6kx3n6m 514 123 metabolic metabolic JJ cord-347946-i6kx3n6m 514 124 responses response NNS cord-347946-i6kx3n6m 514 125 in in IN cord-347946-i6kx3n6m 514 126 children child NNS cord-347946-i6kx3n6m 514 127 with with IN cord-347946-i6kx3n6m 514 128 meningoccocal meningoccocal JJ cord-347946-i6kx3n6m 514 129 sepsis sepsis NN cord-347946-i6kx3n6m 514 130 : : : cord-347946-i6kx3n6m 514 131 striking strike VBG cord-347946-i6kx3n6m 514 132 differences difference NNS cord-347946-i6kx3n6m 514 133 between between IN cord-347946-i6kx3n6m 514 134 survivors survivor NNS cord-347946-i6kx3n6m 514 135 and and CC cord-347946-i6kx3n6m 514 136 nonsurvivors nonsurvivors NNP cord-347946-i6kx3n6m 514 137 Age Age NNP cord-347946-i6kx3n6m 514 138 distribution distribution NN cord-347946-i6kx3n6m 514 139 and and CC cord-347946-i6kx3n6m 514 140 gender gender NN cord-347946-i6kx3n6m 514 141 differences difference NNS cord-347946-i6kx3n6m 514 142 in in IN cord-347946-i6kx3n6m 514 143 psychogenic psychogenic JJ cord-347946-i6kx3n6m 514 144 fever fever NN cord-347946-i6kx3n6m 514 145 patients patient NNS cord-347946-i6kx3n6m 515 1 The the DT cord-347946-i6kx3n6m 515 2 natural natural JJ cord-347946-i6kx3n6m 515 3 history history NN cord-347946-i6kx3n6m 515 4 of of IN cord-347946-i6kx3n6m 515 5 human human JJ cord-347946-i6kx3n6m 515 6 food food NN cord-347946-i6kx3n6m 515 7 sharing sharing NN cord-347946-i6kx3n6m 515 8 and and CC cord-347946-i6kx3n6m 515 9 cooperation cooperation NN cord-347946-i6kx3n6m 515 10 : : : cord-347946-i6kx3n6m 515 11 a a DT cord-347946-i6kx3n6m 515 12 review review NN cord-347946-i6kx3n6m 515 13 and and CC cord-347946-i6kx3n6m 515 14 a a DT cord-347946-i6kx3n6m 515 15 new new JJ cord-347946-i6kx3n6m 515 16 multi multi JJ cord-347946-i6kx3n6m 515 17 - - JJ cord-347946-i6kx3n6m 515 18 individual individual JJ cord-347946-i6kx3n6m 515 19 approach approach NN cord-347946-i6kx3n6m 515 20 to to IN cord-347946-i6kx3n6m 515 21 the the DT cord-347946-i6kx3n6m 515 22 negotiation negotiation NN cord-347946-i6kx3n6m 515 23 of of IN cord-347946-i6kx3n6m 515 24 norms norm NNS cord-347946-i6kx3n6m 515 25 Psychological psychological JJ cord-347946-i6kx3n6m 515 26 stress stress NN cord-347946-i6kx3n6m 515 27 activates activate VBZ cord-347946-i6kx3n6m 515 28 a a DT cord-347946-i6kx3n6m 515 29 dorsomedial dorsomedial JJ cord-347946-i6kx3n6m 515 30 hypothalamus hypothalamus NN cord-347946-i6kx3n6m 515 31 - - HYPH cord-347946-i6kx3n6m 515 32 medullary medullary JJ cord-347946-i6kx3n6m 515 33 raphe raphe NN cord-347946-i6kx3n6m 515 34 circuit circuit NN cord-347946-i6kx3n6m 515 35 driving drive VBG cord-347946-i6kx3n6m 515 36 brown brown JJ cord-347946-i6kx3n6m 515 37 adipose adipose JJ cord-347946-i6kx3n6m 515 38 tissue tissue NN cord-347946-i6kx3n6m 515 39 thermogenesis thermogenesis NN cord-347946-i6kx3n6m 515 40 and and CC cord-347946-i6kx3n6m 515 41 hyperthermia hyperthermia NN cord-347946-i6kx3n6m 515 42 Expression expression NN cord-347946-i6kx3n6m 515 43 of of IN cord-347946-i6kx3n6m 515 44 Toll Toll NNP cord-347946-i6kx3n6m 515 45 - - HYPH cord-347946-i6kx3n6m 515 46 Like like JJ cord-347946-i6kx3n6m 515 47 Receptors receptor NNS cord-347946-i6kx3n6m 515 48 in in IN cord-347946-i6kx3n6m 515 49 peripheral peripheral JJ cord-347946-i6kx3n6m 515 50 blood blood NN cord-347946-i6kx3n6m 515 51 mononuclear mononuclear NN cord-347946-i6kx3n6m 515 52 cells cell NNS cord-347946-i6kx3n6m 515 53 and and CC cord-347946-i6kx3n6m 515 54 response response NN cord-347946-i6kx3n6m 515 55 to to IN cord-347946-i6kx3n6m 515 56 cognitive cognitive JJ cord-347946-i6kx3n6m 515 57 - - HYPH cord-347946-i6kx3n6m 515 58 behavioral behavioral JJ cord-347946-i6kx3n6m 515 59 therapy therapy NN cord-347946-i6kx3n6m 515 60 in in IN cord-347946-i6kx3n6m 515 61 major major JJ cord-347946-i6kx3n6m 515 62 depressive depressive JJ cord-347946-i6kx3n6m 515 63 disorder disorder NN cord-347946-i6kx3n6m 515 64 Early early JJ cord-347946-i6kx3n6m 515 65 school school NN cord-347946-i6kx3n6m 515 66 outcomes outcome NNS cord-347946-i6kx3n6m 515 67 for for IN cord-347946-i6kx3n6m 515 68 children child NNS cord-347946-i6kx3n6m 515 69 of of IN cord-347946-i6kx3n6m 515 70 postpartum postpartum NN cord-347946-i6kx3n6m 515 71 depressed depress VBN cord-347946-i6kx3n6m 515 72 mothers mother NNS cord-347946-i6kx3n6m 515 73 : : : cord-347946-i6kx3n6m 516 1 comparison comparison NN cord-347946-i6kx3n6m 516 2 with with IN cord-347946-i6kx3n6m 516 3 a a DT cord-347946-i6kx3n6m 516 4 community community NN cord-347946-i6kx3n6m 516 5 sample sample NN cord-347946-i6kx3n6m 516 6 Age age NN cord-347946-i6kx3n6m 516 7 differences difference NNS cord-347946-i6kx3n6m 516 8 in in IN cord-347946-i6kx3n6m 516 9 major major JJ cord-347946-i6kx3n6m 516 10 depression depression NN cord-347946-i6kx3n6m 516 11 : : : cord-347946-i6kx3n6m 516 12 results result NNS cord-347946-i6kx3n6m 516 13 from from IN cord-347946-i6kx3n6m 516 14 the the DT cord-347946-i6kx3n6m 516 15 National National NNP cord-347946-i6kx3n6m 516 16 Comorbidity Comorbidity NNP cord-347946-i6kx3n6m 516 17 Survey Survey NNP cord-347946-i6kx3n6m 516 18 Replication Replication NNP cord-347946-i6kx3n6m 516 19 ( ( -LRB- cord-347946-i6kx3n6m 516 20 NCS NCS NNP cord-347946-i6kx3n6m 516 21 - - HYPH cord-347946-i6kx3n6m 516 22 R R NNP cord-347946-i6kx3n6m 516 23 ) ) -RRB- cord-347946-i6kx3n6m 517 1 An an DT cord-347946-i6kx3n6m 517 2 evolutionary evolutionary JJ cord-347946-i6kx3n6m 517 3 hypothesis hypothesis NN cord-347946-i6kx3n6m 517 4 of of IN cord-347946-i6kx3n6m 517 5 depression depression NN cord-347946-i6kx3n6m 517 6 and and CC cord-347946-i6kx3n6m 517 7 its -PRON- PRP$ cord-347946-i6kx3n6m 517 8 symptoms symptom NNS cord-347946-i6kx3n6m 517 9 , , , cord-347946-i6kx3n6m 517 10 adaptive adaptive JJ cord-347946-i6kx3n6m 517 11 value value NN cord-347946-i6kx3n6m 517 12 , , , cord-347946-i6kx3n6m 517 13 and and CC cord-347946-i6kx3n6m 518 1 risk risk NN cord-347946-i6kx3n6m 518 2 factors factor NNS cord-347946-i6kx3n6m 518 3 MyD88 MyD88 NNS cord-347946-i6kx3n6m 518 4 signaling signal VBG cord-347946-i6kx3n6m 518 5 in in IN cord-347946-i6kx3n6m 518 6 the the DT cord-347946-i6kx3n6m 518 7 CNS CNS NNP cord-347946-i6kx3n6m 518 8 is be VBZ cord-347946-i6kx3n6m 518 9 required require VBN cord-347946-i6kx3n6m 518 10 for for IN cord-347946-i6kx3n6m 518 11 development development NN cord-347946-i6kx3n6m 518 12 of of IN cord-347946-i6kx3n6m 518 13 fatty fatty JJ cord-347946-i6kx3n6m 518 14 acidinduced acidinduced JJ cord-347946-i6kx3n6m 518 15 leptin leptin NN cord-347946-i6kx3n6m 518 16 resistance resistance NN cord-347946-i6kx3n6m 518 17 and and CC cord-347946-i6kx3n6m 518 18 diet diet NN cord-347946-i6kx3n6m 518 19 - - HYPH cord-347946-i6kx3n6m 518 20 induced induce VBN cord-347946-i6kx3n6m 518 21 obesity obesity NN cord-347946-i6kx3n6m 518 22 Fever fever NN cord-347946-i6kx3n6m 518 23 and and CC cord-347946-i6kx3n6m 518 24 reduced reduce VBN cord-347946-i6kx3n6m 518 25 iron iron NN cord-347946-i6kx3n6m 518 26 : : : cord-347946-i6kx3n6m 518 27 their -PRON- PRP$ cord-347946-i6kx3n6m 518 28 interaction interaction NN cord-347946-i6kx3n6m 518 29 as as IN cord-347946-i6kx3n6m 518 30 a a DT cord-347946-i6kx3n6m 518 31 host host NN cord-347946-i6kx3n6m 518 32 defense defense NN cord-347946-i6kx3n6m 518 33 response response NN cord-347946-i6kx3n6m 518 34 to to IN cord-347946-i6kx3n6m 518 35 bacterial bacterial JJ cord-347946-i6kx3n6m 518 36 infection infection NN cord-347946-i6kx3n6m 518 37 Histological Histological NNP cord-347946-i6kx3n6m 518 38 analysis analysis NN cord-347946-i6kx3n6m 518 39 of of IN cord-347946-i6kx3n6m 518 40 mammary mammary JJ cord-347946-i6kx3n6m 518 41 gland gland NN cord-347946-i6kx3n6m 518 42 remodeling remodeling NN cord-347946-i6kx3n6m 518 43 caused cause VBN cord-347946-i6kx3n6m 518 44 by by IN cord-347946-i6kx3n6m 518 45 lipopolysaccharide lipopolysaccharide NN cord-347946-i6kx3n6m 518 46 in in IN cord-347946-i6kx3n6m 518 47 lactating lactate VBG cord-347946-i6kx3n6m 518 48 mice mouse NNS cord-347946-i6kx3n6m 519 1 Maternal maternal JJ cord-347946-i6kx3n6m 519 2 psychosocial psychosocial JJ cord-347946-i6kx3n6m 519 3 factors factor NNS cord-347946-i6kx3n6m 519 4 determining determine VBG cord-347946-i6kx3n6m 519 5 the the DT cord-347946-i6kx3n6m 519 6 concentrations concentration NNS cord-347946-i6kx3n6m 519 7 of of IN cord-347946-i6kx3n6m 519 8 transforming transform VBG cord-347946-i6kx3n6m 519 9 growth growth NN cord-347946-i6kx3n6m 519 10 factor factor NN cord-347946-i6kx3n6m 519 11 - - HYPH cord-347946-i6kx3n6m 519 12 beta beta NN cord-347946-i6kx3n6m 519 13 in in IN cord-347946-i6kx3n6m 519 14 breast breast NN cord-347946-i6kx3n6m 519 15 milk milk NN cord-347946-i6kx3n6m 519 16 Microbial microbial JJ cord-347946-i6kx3n6m 519 17 products product NNS cord-347946-i6kx3n6m 519 18 and and CC cord-347946-i6kx3n6m 519 19 cytokines cytokine NNS cord-347946-i6kx3n6m 519 20 in in IN cord-347946-i6kx3n6m 519 21 sleep sleep NN cord-347946-i6kx3n6m 519 22 and and CC cord-347946-i6kx3n6m 519 23 fever fever NN cord-347946-i6kx3n6m 519 24 regulation regulation NN cord-347946-i6kx3n6m 520 1 Humoral Humoral NNP cord-347946-i6kx3n6m 520 2 links link NNS cord-347946-i6kx3n6m 520 3 between between IN cord-347946-i6kx3n6m 520 4 sleep sleep NN cord-347946-i6kx3n6m 520 5 and and CC cord-347946-i6kx3n6m 520 6 the the DT cord-347946-i6kx3n6m 520 7 immune immune JJ cord-347946-i6kx3n6m 520 8 system system NN cord-347946-i6kx3n6m 520 9 : : : cord-347946-i6kx3n6m 520 10 research research NN cord-347946-i6kx3n6m 520 11 issues issue NNS cord-347946-i6kx3n6m 520 12 Cytokines Cytokines NNPS cord-347946-i6kx3n6m 520 13 as as IN cord-347946-i6kx3n6m 520 14 regulators regulator NNS cord-347946-i6kx3n6m 520 15 of of IN cord-347946-i6kx3n6m 520 16 sleep sleep NN cord-347946-i6kx3n6m 520 17 Selection selection NN cord-347946-i6kx3n6m 520 18 for for IN cord-347946-i6kx3n6m 520 19 genetic genetic JJ cord-347946-i6kx3n6m 520 20 variation variation NN cord-347946-i6kx3n6m 520 21 inducing induce VBG cord-347946-i6kx3n6m 520 22 pro pro JJ cord-347946-i6kx3n6m 520 23 - - JJ cord-347946-i6kx3n6m 520 24 inflammatory inflammatory JJ cord-347946-i6kx3n6m 520 25 responses response NNS cord-347946-i6kx3n6m 520 26 under under IN cord-347946-i6kx3n6m 520 27 adverse adverse JJ cord-347946-i6kx3n6m 520 28 environmental environmental JJ cord-347946-i6kx3n6m 520 29 conditions condition NNS cord-347946-i6kx3n6m 520 30 in in IN cord-347946-i6kx3n6m 520 31 a a DT cord-347946-i6kx3n6m 520 32 Ghanaian ghanaian JJ cord-347946-i6kx3n6m 520 33 population population NN cord-347946-i6kx3n6m 520 34 Functional functional JJ cord-347946-i6kx3n6m 520 35 gene gene NN cord-347946-i6kx3n6m 520 36 polymorphisms polymorphism NNS cord-347946-i6kx3n6m 520 37 in in IN cord-347946-i6kx3n6m 520 38 canadian canadian JJ cord-347946-i6kx3n6m 520 39 aboriginal aboriginal JJ cord-347946-i6kx3n6m 520 40 populations population NNS cord-347946-i6kx3n6m 520 41 with with IN cord-347946-i6kx3n6m 520 42 high high JJ cord-347946-i6kx3n6m 520 43 rates rate NNS cord-347946-i6kx3n6m 520 44 of of IN cord-347946-i6kx3n6m 520 45 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 520 46 Turning turn VBG cord-347946-i6kx3n6m 520 47 up up RP cord-347946-i6kx3n6m 520 48 the the DT cord-347946-i6kx3n6m 520 49 heat heat NN cord-347946-i6kx3n6m 520 50 : : : cord-347946-i6kx3n6m 520 51 immune immune JJ cord-347946-i6kx3n6m 520 52 brinksmanship brinksmanship NN cord-347946-i6kx3n6m 520 53 in in IN cord-347946-i6kx3n6m 520 54 the the DT cord-347946-i6kx3n6m 520 55 acute acute JJ cord-347946-i6kx3n6m 520 56 - - HYPH cord-347946-i6kx3n6m 520 57 phase phase NN cord-347946-i6kx3n6m 520 58 response response NN cord-347946-i6kx3n6m 520 59 Role role NN cord-347946-i6kx3n6m 520 60 of of IN cord-347946-i6kx3n6m 520 61 depression depression NN cord-347946-i6kx3n6m 520 62 , , , cord-347946-i6kx3n6m 520 63 stress stress NN cord-347946-i6kx3n6m 520 64 , , , cord-347946-i6kx3n6m 520 65 and and CC cord-347946-i6kx3n6m 520 66 trauma trauma NN cord-347946-i6kx3n6m 520 67 in in IN cord-347946-i6kx3n6m 520 68 HIV HIV NNP cord-347946-i6kx3n6m 520 69 disease disease NN cord-347946-i6kx3n6m 520 70 progression progression NN cord-347946-i6kx3n6m 521 1 Lower low JJR cord-347946-i6kx3n6m 521 2 risk risk NN cord-347946-i6kx3n6m 521 3 of of IN cord-347946-i6kx3n6m 521 4 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 521 5 in in IN cord-347946-i6kx3n6m 521 6 obesity obesity NN cord-347946-i6kx3n6m 521 7 Evaluation Evaluation NNP cord-347946-i6kx3n6m 521 8 of of IN cord-347946-i6kx3n6m 521 9 depression depression NN cord-347946-i6kx3n6m 521 10 as as IN cord-347946-i6kx3n6m 521 11 a a DT cord-347946-i6kx3n6m 521 12 risk risk NN cord-347946-i6kx3n6m 521 13 factor factor NN cord-347946-i6kx3n6m 521 14 for for IN cord-347946-i6kx3n6m 521 15 treatment treatment NN cord-347946-i6kx3n6m 521 16 failure failure NN cord-347946-i6kx3n6m 521 17 in in IN cord-347946-i6kx3n6m 521 18 chronic chronic JJ cord-347946-i6kx3n6m 521 19 hepatitis hepatitis NN cord-347946-i6kx3n6m 521 20 C c NN cord-347946-i6kx3n6m 521 21 Cerebrospinal cerebrospinal NN cord-347946-i6kx3n6m 521 22 cytokine cytokine NN cord-347946-i6kx3n6m 521 23 levels level NNS cord-347946-i6kx3n6m 521 24 in in IN cord-347946-i6kx3n6m 521 25 patients patient NNS cord-347946-i6kx3n6m 521 26 with with IN cord-347946-i6kx3n6m 521 27 acute acute JJ cord-347946-i6kx3n6m 521 28 depression depression NN cord-347946-i6kx3n6m 521 29 Effects effect NNS cord-347946-i6kx3n6m 521 30 of of IN cord-347946-i6kx3n6m 521 31 chronic chronic JJ cord-347946-i6kx3n6m 521 32 stress stress NN cord-347946-i6kx3n6m 521 33 and and CC cord-347946-i6kx3n6m 521 34 interleukin-10 interleukin-10 NN cord-347946-i6kx3n6m 521 35 gene gene NN cord-347946-i6kx3n6m 521 36 polymorphisms polymorphism NNS cord-347946-i6kx3n6m 521 37 on on IN cord-347946-i6kx3n6m 521 38 antibody antibody NN cord-347946-i6kx3n6m 521 39 response response NN cord-347946-i6kx3n6m 521 40 to to IN cord-347946-i6kx3n6m 521 41 tetanus tetanus JJ cord-347946-i6kx3n6m 521 42 vaccine vaccine NN cord-347946-i6kx3n6m 521 43 in in IN cord-347946-i6kx3n6m 521 44 family family NN cord-347946-i6kx3n6m 521 45 caregivers caregiver NNS cord-347946-i6kx3n6m 521 46 of of IN cord-347946-i6kx3n6m 521 47 patients patient NNS cord-347946-i6kx3n6m 521 48 with with IN cord-347946-i6kx3n6m 521 49 Alzheimer Alzheimer NNP cord-347946-i6kx3n6m 521 50 's 's POS cord-347946-i6kx3n6m 521 51 disease disease NN cord-347946-i6kx3n6m 522 1 Elevated elevated JJ cord-347946-i6kx3n6m 522 2 levels level NNS cord-347946-i6kx3n6m 522 3 of of IN cord-347946-i6kx3n6m 522 4 prostaglandin prostaglandin NN cord-347946-i6kx3n6m 522 5 E2 e2 NN cord-347946-i6kx3n6m 522 6 and and CC cord-347946-i6kx3n6m 522 7 thromboxane thromboxane NN cord-347946-i6kx3n6m 522 8 B2 b2 NN cord-347946-i6kx3n6m 522 9 in in IN cord-347946-i6kx3n6m 522 10 depression depression NN cord-347946-i6kx3n6m 522 11 Fueling fuel VBG cord-347946-i6kx3n6m 522 12 the the DT cord-347946-i6kx3n6m 522 13 flame flame NN cord-347946-i6kx3n6m 523 1 : : : cord-347946-i6kx3n6m 523 2 bioenergy bioenergy NN cord-347946-i6kx3n6m 523 3 couples couple NNS cord-347946-i6kx3n6m 523 4 metabolism metabolism VBP cord-347946-i6kx3n6m 523 5 and and CC cord-347946-i6kx3n6m 523 6 inflammation inflammation NN cord-347946-i6kx3n6m 524 1 Interleukin Interleukin NNP cord-347946-i6kx3n6m 524 2 ( ( -LRB- cord-347946-i6kx3n6m 524 3 IL)-6 il)-6 NN cord-347946-i6kx3n6m 524 4 , , , cord-347946-i6kx3n6m 524 5 tumour tumour NN cord-347946-i6kx3n6m 524 6 necrosis necrosis NN cord-347946-i6kx3n6m 524 7 factor factor NN cord-347946-i6kx3n6m 524 8 alpha alpha NN cord-347946-i6kx3n6m 524 9 ( ( -LRB- cord-347946-i6kx3n6m 524 10 TNF tnf NN cord-347946-i6kx3n6m 524 11 - - HYPH cord-347946-i6kx3n6m 524 12 alpha alpha NN cord-347946-i6kx3n6m 524 13 ) ) -RRB- cord-347946-i6kx3n6m 524 14 and and CC cord-347946-i6kx3n6m 524 15 soluble soluble JJ cord-347946-i6kx3n6m 524 16 interleukin-2 interleukin-2 IN cord-347946-i6kx3n6m 524 17 receptors receptor NNS cord-347946-i6kx3n6m 524 18 ( ( -LRB- cord-347946-i6kx3n6m 524 19 sIL-2 sIL-2 NNP cord-347946-i6kx3n6m 524 20 R r NN cord-347946-i6kx3n6m 524 21 ) ) -RRB- cord-347946-i6kx3n6m 524 22 are be VBP cord-347946-i6kx3n6m 524 23 elevated elevate VBN cord-347946-i6kx3n6m 524 24 in in IN cord-347946-i6kx3n6m 524 25 patients patient NNS cord-347946-i6kx3n6m 524 26 with with IN cord-347946-i6kx3n6m 524 27 major major JJ cord-347946-i6kx3n6m 524 28 depressive depressive JJ cord-347946-i6kx3n6m 524 29 disorder disorder NN cord-347946-i6kx3n6m 524 30 : : : cord-347946-i6kx3n6m 524 31 a a DT cord-347946-i6kx3n6m 524 32 meta meta NN cord-347946-i6kx3n6m 524 33 - - HYPH cord-347946-i6kx3n6m 524 34 analysis analysis NN cord-347946-i6kx3n6m 524 35 and and CC cord-347946-i6kx3n6m 524 36 meta meta JJ cord-347946-i6kx3n6m 524 37 - - HYPH cord-347946-i6kx3n6m 524 38 regression regression NNP cord-347946-i6kx3n6m 524 39 Loss Loss NNP cord-347946-i6kx3n6m 524 40 of of IN cord-347946-i6kx3n6m 524 41 Sirt1 Sirt1 NNP cord-347946-i6kx3n6m 524 42 function function NN cord-347946-i6kx3n6m 524 43 improves improve VBZ cord-347946-i6kx3n6m 524 44 intestinal intestinal JJ cord-347946-i6kx3n6m 524 45 anti anti JJ cord-347946-i6kx3n6m 524 46 - - JJ cord-347946-i6kx3n6m 524 47 bacterial bacterial JJ cord-347946-i6kx3n6m 524 48 defense defense NN cord-347946-i6kx3n6m 524 49 and and CC cord-347946-i6kx3n6m 524 50 protects protect VBZ cord-347946-i6kx3n6m 524 51 from from IN cord-347946-i6kx3n6m 524 52 colitis colitis NN cord-347946-i6kx3n6m 524 53 - - HYPH cord-347946-i6kx3n6m 524 54 induced induce VBN cord-347946-i6kx3n6m 524 55 colorectal colorectal JJ cord-347946-i6kx3n6m 524 56 cancer cancer NN cord-347946-i6kx3n6m 524 57 Major major JJ cord-347946-i6kx3n6m 524 58 depression depression NN cord-347946-i6kx3n6m 524 59 during during IN cord-347946-i6kx3n6m 524 60 interferon interferon NN cord-347946-i6kx3n6m 524 61 - - HYPH cord-347946-i6kx3n6m 524 62 alpha alpha NN cord-347946-i6kx3n6m 524 63 treatment treatment NN cord-347946-i6kx3n6m 524 64 : : : cord-347946-i6kx3n6m 525 1 vulnerability vulnerability NN cord-347946-i6kx3n6m 525 2 and and CC cord-347946-i6kx3n6m 525 3 prevention prevention NN cord-347946-i6kx3n6m 525 4 Risk risk NN cord-347946-i6kx3n6m 525 5 for for IN cord-347946-i6kx3n6m 525 6 depression depression NN cord-347946-i6kx3n6m 525 7 during during IN cord-347946-i6kx3n6m 525 8 interferon interferon NN cord-347946-i6kx3n6m 525 9 - - HYPH cord-347946-i6kx3n6m 525 10 alpha alpha NN cord-347946-i6kx3n6m 525 11 treatment treatment NN cord-347946-i6kx3n6m 525 12 is be VBZ cord-347946-i6kx3n6m 525 13 affected affect VBN cord-347946-i6kx3n6m 525 14 by by IN cord-347946-i6kx3n6m 525 15 the the DT cord-347946-i6kx3n6m 525 16 serotonin serotonin NN cord-347946-i6kx3n6m 525 17 transporter transporter NN cord-347946-i6kx3n6m 525 18 polymorphism polymorphism NN cord-347946-i6kx3n6m 525 19 Variability variability NN cord-347946-i6kx3n6m 525 20 in in IN cord-347946-i6kx3n6m 525 21 the the DT cord-347946-i6kx3n6m 525 22 measurement measurement NN cord-347946-i6kx3n6m 525 23 of of IN cord-347946-i6kx3n6m 525 24 C C NNP cord-347946-i6kx3n6m 525 25 - - HYPH cord-347946-i6kx3n6m 525 26 reactive reactive JJ cord-347946-i6kx3n6m 525 27 protein protein NN cord-347946-i6kx3n6m 525 28 in in IN cord-347946-i6kx3n6m 525 29 healthy healthy JJ cord-347946-i6kx3n6m 525 30 subjects subject NNS cord-347946-i6kx3n6m 525 31 : : : cord-347946-i6kx3n6m 525 32 implications implication NNS cord-347946-i6kx3n6m 525 33 for for IN cord-347946-i6kx3n6m 525 34 reference reference NN cord-347946-i6kx3n6m 525 35 intervals interval NNS cord-347946-i6kx3n6m 525 36 and and CC cord-347946-i6kx3n6m 525 37 epidemiological epidemiological JJ cord-347946-i6kx3n6m 525 38 applications application NNS cord-347946-i6kx3n6m 526 1 Major major JJ cord-347946-i6kx3n6m 526 2 depression depression NN cord-347946-i6kx3n6m 526 3 and and CC cord-347946-i6kx3n6m 526 4 activation activation NN cord-347946-i6kx3n6m 526 5 of of IN cord-347946-i6kx3n6m 526 6 the the DT cord-347946-i6kx3n6m 526 7 inflammatory inflammatory JJ cord-347946-i6kx3n6m 526 8 response response NN cord-347946-i6kx3n6m 526 9 system system NN cord-347946-i6kx3n6m 526 10 Increased increase VBN cord-347946-i6kx3n6m 526 11 plasma plasma NN cord-347946-i6kx3n6m 526 12 concentrations concentration NNS cord-347946-i6kx3n6m 526 13 of of IN cord-347946-i6kx3n6m 526 14 interleukin-6 interleukin-6 NNP cord-347946-i6kx3n6m 526 15 , , , cord-347946-i6kx3n6m 526 16 soluble soluble JJ cord-347946-i6kx3n6m 526 17 interleukin-6 interleukin-6 NNP cord-347946-i6kx3n6m 526 18 , , , cord-347946-i6kx3n6m 526 19 soluble soluble JJ cord-347946-i6kx3n6m 526 20 interleukin-2 interleukin-2 NN cord-347946-i6kx3n6m 526 21 and and CC cord-347946-i6kx3n6m 526 22 transferrin transferrin NN cord-347946-i6kx3n6m 526 23 receptor receptor NN cord-347946-i6kx3n6m 526 24 in in IN cord-347946-i6kx3n6m 526 25 major major JJ cord-347946-i6kx3n6m 526 26 depression depression NN cord-347946-i6kx3n6m 526 27 Psychomotor Psychomotor NNP cord-347946-i6kx3n6m 526 28 retardation retardation NN cord-347946-i6kx3n6m 526 29 , , , cord-347946-i6kx3n6m 526 30 anorexia anorexia NN cord-347946-i6kx3n6m 526 31 , , , cord-347946-i6kx3n6m 526 32 weight weight NN cord-347946-i6kx3n6m 526 33 loss loss NN cord-347946-i6kx3n6m 526 34 , , , cord-347946-i6kx3n6m 526 35 sleep sleep NN cord-347946-i6kx3n6m 526 36 disturbances disturbance NNS cord-347946-i6kx3n6m 526 37 , , , cord-347946-i6kx3n6m 526 38 and and CC cord-347946-i6kx3n6m 526 39 loss loss NN cord-347946-i6kx3n6m 526 40 of of IN cord-347946-i6kx3n6m 526 41 energy energy NN cord-347946-i6kx3n6m 526 42 : : : cord-347946-i6kx3n6m 526 43 psychopathological psychopathological JJ cord-347946-i6kx3n6m 526 44 correlates correlate NNS cord-347946-i6kx3n6m 526 45 of of IN cord-347946-i6kx3n6m 526 46 hyperhaptoglobinemia hyperhaptoglobinemia NN cord-347946-i6kx3n6m 526 47 during during IN cord-347946-i6kx3n6m 526 48 major major JJ cord-347946-i6kx3n6m 526 49 depression depression NN cord-347946-i6kx3n6m 527 1 IFN IFN NNP cord-347946-i6kx3n6m 527 2 - - HYPH cord-347946-i6kx3n6m 527 3 alpha alpha NN cord-347946-i6kx3n6m 527 4 - - HYPH cord-347946-i6kx3n6m 527 5 induced induce VBN cord-347946-i6kx3n6m 527 6 motor motor NN cord-347946-i6kx3n6m 527 7 slowing slowing NN cord-347946-i6kx3n6m 527 8 is be VBZ cord-347946-i6kx3n6m 527 9 associated associate VBN cord-347946-i6kx3n6m 527 10 with with IN cord-347946-i6kx3n6m 527 11 increased increase VBN cord-347946-i6kx3n6m 527 12 depression depression NN cord-347946-i6kx3n6m 527 13 and and CC cord-347946-i6kx3n6m 527 14 fatigue fatigue NN cord-347946-i6kx3n6m 527 15 in in IN cord-347946-i6kx3n6m 527 16 patients patient NNS cord-347946-i6kx3n6m 527 17 with with IN cord-347946-i6kx3n6m 527 18 chronic chronic JJ cord-347946-i6kx3n6m 527 19 hepatitis hepatitis NN cord-347946-i6kx3n6m 527 20 C c NN cord-347946-i6kx3n6m 527 21 Depression depression NN cord-347946-i6kx3n6m 527 22 with with IN cord-347946-i6kx3n6m 527 23 atypical atypical JJ cord-347946-i6kx3n6m 527 24 features feature NNS cord-347946-i6kx3n6m 527 25 in in IN cord-347946-i6kx3n6m 527 26 the the DT cord-347946-i6kx3n6m 527 27 National National NNP cord-347946-i6kx3n6m 527 28 Comorbidity Comorbidity NNP cord-347946-i6kx3n6m 527 29 Survey Survey NNP cord-347946-i6kx3n6m 527 30 : : : cord-347946-i6kx3n6m 527 31 classification classification NN cord-347946-i6kx3n6m 527 32 , , , cord-347946-i6kx3n6m 527 33 description description NN cord-347946-i6kx3n6m 527 34 , , , cord-347946-i6kx3n6m 527 35 and and CC cord-347946-i6kx3n6m 527 36 consequences consequence VBZ cord-347946-i6kx3n6m 527 37 Adverse adverse JJ cord-347946-i6kx3n6m 527 38 environmental environmental JJ cord-347946-i6kx3n6m 527 39 conditions condition NNS cord-347946-i6kx3n6m 527 40 influence influence VBP cord-347946-i6kx3n6m 527 41 age age NN cord-347946-i6kx3n6m 527 42 - - HYPH cord-347946-i6kx3n6m 527 43 related relate VBN cord-347946-i6kx3n6m 527 44 innate innate JJ cord-347946-i6kx3n6m 527 45 immune immune JJ cord-347946-i6kx3n6m 527 46 responsiveness responsiveness NN cord-347946-i6kx3n6m 527 47 Influenza Influenza NNP cord-347946-i6kx3n6m 527 48 virus virus NN cord-347946-i6kx3n6m 527 49 - - HYPH cord-347946-i6kx3n6m 527 50 specific specific JJ cord-347946-i6kx3n6m 527 51 immunological immunological JJ cord-347946-i6kx3n6m 527 52 memory memory NN cord-347946-i6kx3n6m 527 53 is be VBZ cord-347946-i6kx3n6m 527 54 enhanced enhance VBN cord-347946-i6kx3n6m 527 55 by by IN cord-347946-i6kx3n6m 527 56 repeated repeat VBN cord-347946-i6kx3n6m 527 57 social social JJ cord-347946-i6kx3n6m 527 58 defeat defeat NN cord-347946-i6kx3n6m 527 59 Stress Stress NNP cord-347946-i6kx3n6m 527 60 and and CC cord-347946-i6kx3n6m 527 61 the the DT cord-347946-i6kx3n6m 527 62 anti anti JJ cord-347946-i6kx3n6m 527 63 - - JJ cord-347946-i6kx3n6m 527 64 influenza influenza JJ cord-347946-i6kx3n6m 527 65 immune immune JJ cord-347946-i6kx3n6m 527 66 response response NN cord-347946-i6kx3n6m 527 67 : : : cord-347946-i6kx3n6m 527 68 repeated repeat VBN cord-347946-i6kx3n6m 527 69 social social JJ cord-347946-i6kx3n6m 527 70 defeat defeat NN cord-347946-i6kx3n6m 527 71 augments augment VBZ cord-347946-i6kx3n6m 527 72 clonal clonal JJ cord-347946-i6kx3n6m 527 73 expansion expansion NN cord-347946-i6kx3n6m 527 74 of of IN cord-347946-i6kx3n6m 527 75 CD8(+)T CD8(+)T NNP cord-347946-i6kx3n6m 527 76 cells cell NNS cord-347946-i6kx3n6m 527 77 during during IN cord-347946-i6kx3n6m 527 78 primary primary JJ cord-347946-i6kx3n6m 527 79 influenza influenza NN cord-347946-i6kx3n6m 527 80 A a DT cord-347946-i6kx3n6m 527 81 viral viral JJ cord-347946-i6kx3n6m 527 82 infection infection NN cord-347946-i6kx3n6m 527 83 Influenza influenza NN cord-347946-i6kx3n6m 527 84 enhances enhance VBZ cord-347946-i6kx3n6m 527 85 susceptibility susceptibility NN cord-347946-i6kx3n6m 527 86 to to IN cord-347946-i6kx3n6m 527 87 natural natural JJ cord-347946-i6kx3n6m 527 88 acquisition acquisition NN cord-347946-i6kx3n6m 527 89 of of IN cord-347946-i6kx3n6m 527 90 and and CC cord-347946-i6kx3n6m 527 91 disease disease NN cord-347946-i6kx3n6m 527 92 due due IN cord-347946-i6kx3n6m 527 93 to to IN cord-347946-i6kx3n6m 527 94 Streptococcus streptococcus NN cord-347946-i6kx3n6m 527 95 pneumoniae pneumoniae NN cord-347946-i6kx3n6m 527 96 in in IN cord-347946-i6kx3n6m 527 97 ferrets ferret NNS cord-347946-i6kx3n6m 527 98 Trade Trade NNP cord-347946-i6kx3n6m 527 99 - - HYPH cord-347946-i6kx3n6m 527 100 offs off NNS cord-347946-i6kx3n6m 527 101 between between IN cord-347946-i6kx3n6m 527 102 acquired acquired JJ cord-347946-i6kx3n6m 527 103 and and CC cord-347946-i6kx3n6m 527 104 innate innate JJ cord-347946-i6kx3n6m 527 105 immune immune JJ cord-347946-i6kx3n6m 527 106 defenses defense NNS cord-347946-i6kx3n6m 527 107 in in IN cord-347946-i6kx3n6m 527 108 humans human NNS cord-347946-i6kx3n6m 528 1 Do do VBP cord-347946-i6kx3n6m 528 2 environments environment NNS cord-347946-i6kx3n6m 528 3 in in IN cord-347946-i6kx3n6m 528 4 infancy infancy NN cord-347946-i6kx3n6m 528 5 moderate moderate JJ cord-347946-i6kx3n6m 528 6 the the DT cord-347946-i6kx3n6m 528 7 association association NN cord-347946-i6kx3n6m 528 8 between between IN cord-347946-i6kx3n6m 528 9 stress stress NN cord-347946-i6kx3n6m 528 10 and and CC cord-347946-i6kx3n6m 528 11 inflammation inflammation NN cord-347946-i6kx3n6m 528 12 in in IN cord-347946-i6kx3n6m 528 13 adulthood adulthood NN cord-347946-i6kx3n6m 528 14 ? ? . cord-347946-i6kx3n6m 529 1 Initial initial JJ cord-347946-i6kx3n6m 529 2 evidence evidence NN cord-347946-i6kx3n6m 529 3 from from IN cord-347946-i6kx3n6m 529 4 a a DT cord-347946-i6kx3n6m 529 5 birth birth NN cord-347946-i6kx3n6m 529 6 cohort cohort NN cord-347946-i6kx3n6m 529 7 in in IN cord-347946-i6kx3n6m 529 8 the the DT cord-347946-i6kx3n6m 529 9 Philippines Philippines NNP cord-347946-i6kx3n6m 529 10 Population Population NNP cord-347946-i6kx3n6m 529 11 differences difference NNS cord-347946-i6kx3n6m 529 12 in in IN cord-347946-i6kx3n6m 529 13 associations association NNS cord-347946-i6kx3n6m 529 14 between between IN cord-347946-i6kx3n6m 529 15 C c NN cord-347946-i6kx3n6m 529 16 - - HYPH cord-347946-i6kx3n6m 529 17 reactive reactive JJ cord-347946-i6kx3n6m 529 18 protein protein NN cord-347946-i6kx3n6m 529 19 concentration concentration NN cord-347946-i6kx3n6m 529 20 and and CC cord-347946-i6kx3n6m 529 21 adiposity adiposity NN cord-347946-i6kx3n6m 529 22 : : : cord-347946-i6kx3n6m 530 1 comparison comparison NN cord-347946-i6kx3n6m 530 2 of of IN cord-347946-i6kx3n6m 530 3 young young JJ cord-347946-i6kx3n6m 530 4 adults adult NNS cord-347946-i6kx3n6m 530 5 in in IN cord-347946-i6kx3n6m 530 6 the the DT cord-347946-i6kx3n6m 530 7 Philippines Philippines NNPS cord-347946-i6kx3n6m 530 8 and and CC cord-347946-i6kx3n6m 530 9 the the DT cord-347946-i6kx3n6m 530 10 United United NNP cord-347946-i6kx3n6m 530 11 States States NNP cord-347946-i6kx3n6m 530 12 Analysis Analysis NNP cord-347946-i6kx3n6m 530 13 of of IN cord-347946-i6kx3n6m 530 14 variability variability NN cord-347946-i6kx3n6m 530 15 of of IN cord-347946-i6kx3n6m 530 16 high high JJ cord-347946-i6kx3n6m 530 17 sensitivity sensitivity NN cord-347946-i6kx3n6m 530 18 C c NN cord-347946-i6kx3n6m 530 19 - - HYPH cord-347946-i6kx3n6m 530 20 reactive reactive JJ cord-347946-i6kx3n6m 530 21 protein protein NN cord-347946-i6kx3n6m 530 22 in in IN cord-347946-i6kx3n6m 530 23 lowland lowland JJ cord-347946-i6kx3n6m 530 24 Ecuador Ecuador NNP cord-347946-i6kx3n6m 530 25 reveals reveal VBZ cord-347946-i6kx3n6m 530 26 no no DT cord-347946-i6kx3n6m 530 27 evidence evidence NN cord-347946-i6kx3n6m 530 28 of of IN cord-347946-i6kx3n6m 530 29 chronic chronic JJ cord-347946-i6kx3n6m 530 30 low low JJ cord-347946-i6kx3n6m 530 31 - - HYPH cord-347946-i6kx3n6m 530 32 grade grade NN cord-347946-i6kx3n6m 530 33 inflammation inflammation NN cord-347946-i6kx3n6m 531 1 A a DT cord-347946-i6kx3n6m 531 2 haplotype haplotype NN cord-347946-i6kx3n6m 531 3 at at IN cord-347946-i6kx3n6m 531 4 STAT2 STAT2 NNS cord-347946-i6kx3n6m 532 1 Introgressed introgresse VBN cord-347946-i6kx3n6m 532 2 from from IN cord-347946-i6kx3n6m 532 3 neanderthals neanderthal NNS cord-347946-i6kx3n6m 532 4 and and CC cord-347946-i6kx3n6m 532 5 serves serve VBZ cord-347946-i6kx3n6m 532 6 as as IN cord-347946-i6kx3n6m 532 7 a a DT cord-347946-i6kx3n6m 532 8 candidate candidate NN cord-347946-i6kx3n6m 532 9 of of IN cord-347946-i6kx3n6m 532 10 positive positive JJ cord-347946-i6kx3n6m 532 11 selection selection NN cord-347946-i6kx3n6m 532 12 in in IN cord-347946-i6kx3n6m 532 13 Papua Papua NNP cord-347946-i6kx3n6m 532 14 New New NNP cord-347946-i6kx3n6m 532 15 Guinea Guinea NNP cord-347946-i6kx3n6m 532 16 Sirtuins Sirtuins NNP cord-347946-i6kx3n6m 532 17 in in IN cord-347946-i6kx3n6m 532 18 mammals mammal NNS cord-347946-i6kx3n6m 532 19 : : : cord-347946-i6kx3n6m 533 1 insights insight NNS cord-347946-i6kx3n6m 533 2 into into IN cord-347946-i6kx3n6m 533 3 their -PRON- PRP$ cord-347946-i6kx3n6m 533 4 biological biological JJ cord-347946-i6kx3n6m 533 5 function function NN cord-347946-i6kx3n6m 534 1 Saturated saturated JJ cord-347946-i6kx3n6m 534 2 fatty fatty JJ cord-347946-i6kx3n6m 534 3 acids acid NNS cord-347946-i6kx3n6m 534 4 produce produce VBP cord-347946-i6kx3n6m 534 5 an an DT cord-347946-i6kx3n6m 534 6 inflammatory inflammatory JJ cord-347946-i6kx3n6m 534 7 response response NN cord-347946-i6kx3n6m 534 8 predominantly predominantly RB cord-347946-i6kx3n6m 534 9 through through IN cord-347946-i6kx3n6m 534 10 the the DT cord-347946-i6kx3n6m 534 11 activation activation NN cord-347946-i6kx3n6m 534 12 of of IN cord-347946-i6kx3n6m 534 13 TLR4 TLR4 NNP cord-347946-i6kx3n6m 534 14 signaling signal VBG cord-347946-i6kx3n6m 534 15 in in IN cord-347946-i6kx3n6m 534 16 hypothalamus hypothalamus NN cord-347946-i6kx3n6m 534 17 : : : cord-347946-i6kx3n6m 534 18 implications implication NNS cord-347946-i6kx3n6m 534 19 for for IN cord-347946-i6kx3n6m 534 20 the the DT cord-347946-i6kx3n6m 534 21 pathogenesis pathogenesis NN cord-347946-i6kx3n6m 534 22 of of IN cord-347946-i6kx3n6m 534 23 obesity obesity NN cord-347946-i6kx3n6m 535 1 The the DT cord-347946-i6kx3n6m 535 2 role role NN cord-347946-i6kx3n6m 535 3 of of IN cord-347946-i6kx3n6m 535 4 inflammation inflammation NN cord-347946-i6kx3n6m 535 5 in in IN cord-347946-i6kx3n6m 535 6 depression depression NN cord-347946-i6kx3n6m 535 7 : : : cord-347946-i6kx3n6m 535 8 from from IN cord-347946-i6kx3n6m 535 9 evolutionary evolutionary JJ cord-347946-i6kx3n6m 535 10 imperative imperative NN cord-347946-i6kx3n6m 535 11 to to IN cord-347946-i6kx3n6m 535 12 modern modern JJ cord-347946-i6kx3n6m 535 13 treatment treatment NN cord-347946-i6kx3n6m 535 14 target target NN cord-347946-i6kx3n6m 535 15 Infectious infectious JJ cord-347946-i6kx3n6m 535 16 disease disease NN cord-347946-i6kx3n6m 535 17 and and CC cord-347946-i6kx3n6m 535 18 psychoneuroimmunology psychoneuroimmunology NN cord-347946-i6kx3n6m 535 19 Viral viral JJ cord-347946-i6kx3n6m 535 20 obesity obesity NN cord-347946-i6kx3n6m 535 21 : : : cord-347946-i6kx3n6m 535 22 fact fact NN cord-347946-i6kx3n6m 535 23 or or CC cord-347946-i6kx3n6m 535 24 fiction fiction NN cord-347946-i6kx3n6m 535 25 ? ? . cord-347946-i6kx3n6m 536 1 Trait trait NN cord-347946-i6kx3n6m 536 2 sensitivity sensitivity NN cord-347946-i6kx3n6m 536 3 to to IN cord-347946-i6kx3n6m 536 4 social social JJ cord-347946-i6kx3n6m 536 5 disconnection disconnection NN cord-347946-i6kx3n6m 536 6 enhances enhance VBZ cord-347946-i6kx3n6m 536 7 pro pro JJ cord-347946-i6kx3n6m 536 8 - - JJ cord-347946-i6kx3n6m 536 9 inflammatory inflammatory JJ cord-347946-i6kx3n6m 536 10 responses response NNS cord-347946-i6kx3n6m 536 11 to to IN cord-347946-i6kx3n6m 536 12 a a DT cord-347946-i6kx3n6m 536 13 randomized randomized JJ cord-347946-i6kx3n6m 536 14 controlled control VBN cord-347946-i6kx3n6m 536 15 trial trial NN cord-347946-i6kx3n6m 536 16 of of IN cord-347946-i6kx3n6m 536 17 endotoxin endotoxin NN cord-347946-i6kx3n6m 536 18 Sex sex NN cord-347946-i6kx3n6m 536 19 differences difference NNS cord-347946-i6kx3n6m 536 20 in in IN cord-347946-i6kx3n6m 536 21 depressive depressive JJ cord-347946-i6kx3n6m 536 22 and and CC cord-347946-i6kx3n6m 536 23 socioemotional socioemotional JJ cord-347946-i6kx3n6m 536 24 responses response NNS cord-347946-i6kx3n6m 536 25 to to IN cord-347946-i6kx3n6m 536 26 an an DT cord-347946-i6kx3n6m 536 27 inflammatory inflammatory JJ cord-347946-i6kx3n6m 536 28 challenge challenge NN cord-347946-i6kx3n6m 536 29 : : : cord-347946-i6kx3n6m 536 30 implications implication NNS cord-347946-i6kx3n6m 536 31 for for IN cord-347946-i6kx3n6m 536 32 sex sex NN cord-347946-i6kx3n6m 536 33 differences difference NNS cord-347946-i6kx3n6m 536 34 in in IN cord-347946-i6kx3n6m 536 35 depression depression NN cord-347946-i6kx3n6m 537 1 The the DT cord-347946-i6kx3n6m 537 2 effect effect NN cord-347946-i6kx3n6m 537 3 of of IN cord-347946-i6kx3n6m 537 4 HIV HIV NNP cord-347946-i6kx3n6m 537 5 infection infection NN cord-347946-i6kx3n6m 537 6 on on IN cord-347946-i6kx3n6m 537 7 paediatric paediatric JJ cord-347946-i6kx3n6m 537 8 bacterial bacterial JJ cord-347946-i6kx3n6m 537 9 meningitis meningitis NN cord-347946-i6kx3n6m 537 10 in in IN cord-347946-i6kx3n6m 537 11 Elevated elevated JJ cord-347946-i6kx3n6m 537 12 IL-1beta il-1beta NN cord-347946-i6kx3n6m 537 13 contributes contribute VBZ cord-347946-i6kx3n6m 537 14 to to IN cord-347946-i6kx3n6m 537 15 antibody antibody NN cord-347946-i6kx3n6m 537 16 suppression suppression NN cord-347946-i6kx3n6m 537 17 produced produce VBN cord-347946-i6kx3n6m 537 18 by by IN cord-347946-i6kx3n6m 537 19 stress stress NN cord-347946-i6kx3n6m 537 20 Sex sex NN cord-347946-i6kx3n6m 537 21 differences difference NNS cord-347946-i6kx3n6m 537 22 in in IN cord-347946-i6kx3n6m 537 23 depressive depressive JJ cord-347946-i6kx3n6m 537 24 and and CC cord-347946-i6kx3n6m 537 25 socioemotional socioemotional JJ cord-347946-i6kx3n6m 537 26 responses response NNS cord-347946-i6kx3n6m 537 27 to to IN cord-347946-i6kx3n6m 537 28 an an DT cord-347946-i6kx3n6m 537 29 inflammatory inflammatory JJ cord-347946-i6kx3n6m 537 30 challenge challenge NN cord-347946-i6kx3n6m 537 31 : : : cord-347946-i6kx3n6m 537 32 implications implication NNS cord-347946-i6kx3n6m 537 33 for for IN cord-347946-i6kx3n6m 537 34 sex sex NN cord-347946-i6kx3n6m 537 35 differences difference NNS cord-347946-i6kx3n6m 537 36 in in IN cord-347946-i6kx3n6m 537 37 depression depression NN cord-347946-i6kx3n6m 537 38 Depression depression NN cord-347946-i6kx3n6m 537 39 , , , cord-347946-i6kx3n6m 537 40 chronic chronic JJ cord-347946-i6kx3n6m 537 41 diseases disease NNS cord-347946-i6kx3n6m 537 42 , , , cord-347946-i6kx3n6m 537 43 and and CC cord-347946-i6kx3n6m 537 44 decrements decrement VBZ cord-347946-i6kx3n6m 537 45 in in IN cord-347946-i6kx3n6m 537 46 health health NN cord-347946-i6kx3n6m 537 47 : : : cord-347946-i6kx3n6m 537 48 results result NNS cord-347946-i6kx3n6m 537 49 from from IN cord-347946-i6kx3n6m 537 50 the the DT cord-347946-i6kx3n6m 537 51 World World NNP cord-347946-i6kx3n6m 537 52 Health Health NNP cord-347946-i6kx3n6m 537 53 Surveys Surveys NNPS cord-347946-i6kx3n6m 537 54 Chronic Chronic NNP cord-347946-i6kx3n6m 537 55 inflammation inflammation NN cord-347946-i6kx3n6m 537 56 that that WDT cord-347946-i6kx3n6m 537 57 facilitates facilitate VBZ cord-347946-i6kx3n6m 537 58 tumor tumor NN cord-347946-i6kx3n6m 537 59 progression progression NN cord-347946-i6kx3n6m 537 60 creates create VBZ cord-347946-i6kx3n6m 537 61 local local JJ cord-347946-i6kx3n6m 537 62 immune immune JJ cord-347946-i6kx3n6m 537 63 suppression suppression NN cord-347946-i6kx3n6m 537 64 by by IN cord-347946-i6kx3n6m 537 65 inducing induce VBG cord-347946-i6kx3n6m 537 66 indoleamine indoleamine NN cord-347946-i6kx3n6m 537 67 2,3 2,3 CD cord-347946-i6kx3n6m 537 68 dioxygenase dioxygenase NN cord-347946-i6kx3n6m 537 69 Higher higher RBR cord-347946-i6kx3n6m 537 70 than than IN cord-347946-i6kx3n6m 537 71 normal normal JJ cord-347946-i6kx3n6m 537 72 plasma plasma NN cord-347946-i6kx3n6m 537 73 interleukin-6 interleukin-6 NNP cord-347946-i6kx3n6m 537 74 concentrations concentration NNS cord-347946-i6kx3n6m 537 75 in in IN cord-347946-i6kx3n6m 537 76 cancer cancer NN cord-347946-i6kx3n6m 537 77 patients patient NNS cord-347946-i6kx3n6m 537 78 with with IN cord-347946-i6kx3n6m 537 79 depression depression NN cord-347946-i6kx3n6m 537 80 : : : cord-347946-i6kx3n6m 537 81 preliminary preliminary JJ cord-347946-i6kx3n6m 537 82 findings finding NNS cord-347946-i6kx3n6m 537 83 Synergism synergism NN cord-347946-i6kx3n6m 537 84 for for IN cord-347946-i6kx3n6m 537 85 cytokine cytokine NN cord-347946-i6kx3n6m 537 86 - - HYPH cord-347946-i6kx3n6m 537 87 mediated mediate VBN cord-347946-i6kx3n6m 537 88 disease disease NN cord-347946-i6kx3n6m 537 89 during during IN cord-347946-i6kx3n6m 537 90 concurrent concurrent JJ cord-347946-i6kx3n6m 537 91 endotoxin endotoxin NN cord-347946-i6kx3n6m 537 92 and and CC cord-347946-i6kx3n6m 537 93 viral viral JJ cord-347946-i6kx3n6m 537 94 challenges challenge NNS cord-347946-i6kx3n6m 537 95 : : : cord-347946-i6kx3n6m 537 96 roles role NNS cord-347946-i6kx3n6m 537 97 for for IN cord-347946-i6kx3n6m 537 98 NK NK NNP cord-347946-i6kx3n6m 537 99 and and CC cord-347946-i6kx3n6m 537 100 T T NNP cord-347946-i6kx3n6m 537 101 cell cell NN cord-347946-i6kx3n6m 537 102 IFN IFN NNP cord-347946-i6kx3n6m 537 103 - - HYPH cord-347946-i6kx3n6m 537 104 gamma gamma NN cord-347946-i6kx3n6m 537 105 production production NN cord-347946-i6kx3n6m 537 106 Depression depression NN cord-347946-i6kx3n6m 537 107 , , , cord-347946-i6kx3n6m 537 108 anxiety anxiety NN cord-347946-i6kx3n6m 537 109 , , , cord-347946-i6kx3n6m 537 110 and and CC cord-347946-i6kx3n6m 537 111 psychotropic psychotropic JJ cord-347946-i6kx3n6m 537 112 medication medication NN cord-347946-i6kx3n6m 537 113 use use NN cord-347946-i6kx3n6m 537 114 and and CC cord-347946-i6kx3n6m 537 115 fecundability fecundability NN cord-347946-i6kx3n6m 537 116 Variability variability NN cord-347946-i6kx3n6m 537 117 and and CC cord-347946-i6kx3n6m 537 118 classification classification NN cord-347946-i6kx3n6m 537 119 accuracy accuracy NN cord-347946-i6kx3n6m 537 120 of of IN cord-347946-i6kx3n6m 537 121 serial serial JJ cord-347946-i6kx3n6m 537 122 high high JJ cord-347946-i6kx3n6m 537 123 - - HYPH cord-347946-i6kx3n6m 537 124 sensitivity sensitivity NN cord-347946-i6kx3n6m 537 125 C c NN cord-347946-i6kx3n6m 537 126 - - HYPH cord-347946-i6kx3n6m 537 127 reactive reactive JJ cord-347946-i6kx3n6m 537 128 protein protein NN cord-347946-i6kx3n6m 537 129 measurements measurement NNS cord-347946-i6kx3n6m 537 130 in in IN cord-347946-i6kx3n6m 537 131 healthy healthy JJ cord-347946-i6kx3n6m 537 132 adults adult NNS cord-347946-i6kx3n6m 538 1 A a DT cord-347946-i6kx3n6m 538 2 systematic systematic JJ cord-347946-i6kx3n6m 538 3 review review NN cord-347946-i6kx3n6m 538 4 of of IN cord-347946-i6kx3n6m 538 5 the the DT cord-347946-i6kx3n6m 538 6 importance importance NN cord-347946-i6kx3n6m 538 7 of of IN cord-347946-i6kx3n6m 538 8 milk milk NN cord-347946-i6kx3n6m 538 9 TGF TGF NNP cord-347946-i6kx3n6m 538 10 - - HYPH cord-347946-i6kx3n6m 538 11 beta beta NN cord-347946-i6kx3n6m 538 12 on on IN cord-347946-i6kx3n6m 538 13 immunological immunological JJ cord-347946-i6kx3n6m 538 14 outcomes outcome NNS cord-347946-i6kx3n6m 538 15 in in IN cord-347946-i6kx3n6m 538 16 the the DT cord-347946-i6kx3n6m 538 17 infant infant NN cord-347946-i6kx3n6m 538 18 and and CC cord-347946-i6kx3n6m 538 19 young young JJ cord-347946-i6kx3n6m 538 20 child child NN cord-347946-i6kx3n6m 538 21 Role role NN cord-347946-i6kx3n6m 538 22 of of IN cord-347946-i6kx3n6m 538 23 transforming transform VBG cord-347946-i6kx3n6m 538 24 growth growth NN cord-347946-i6kx3n6m 538 25 factor factor NN cord-347946-i6kx3n6m 538 26 - - HYPH cord-347946-i6kx3n6m 538 27 beta beta NN cord-347946-i6kx3n6m 538 28 in in IN cord-347946-i6kx3n6m 538 29 breast breast NN cord-347946-i6kx3n6m 538 30 milk milk NN cord-347946-i6kx3n6m 538 31 for for IN cord-347946-i6kx3n6m 538 32 initiation initiation NN cord-347946-i6kx3n6m 538 33 of of IN cord-347946-i6kx3n6m 538 34 IgA IgA NNP cord-347946-i6kx3n6m 538 35 production production NN cord-347946-i6kx3n6m 538 36 in in IN cord-347946-i6kx3n6m 538 37 newborn newborn JJ cord-347946-i6kx3n6m 538 38 infants infant NNS cord-347946-i6kx3n6m 538 39 Cytokines Cytokines NNPS cord-347946-i6kx3n6m 538 40 and and CC cord-347946-i6kx3n6m 538 41 sleep sleep NN cord-347946-i6kx3n6m 538 42 : : : cord-347946-i6kx3n6m 538 43 the the DT cord-347946-i6kx3n6m 538 44 first first JJ cord-347946-i6kx3n6m 538 45 hundred hundred CD cord-347946-i6kx3n6m 538 46 years year NNS cord-347946-i6kx3n6m 538 47 Sleeping sleep VBG cord-347946-i6kx3n6m 538 48 to to TO cord-347946-i6kx3n6m 538 49 fuel fuel VB cord-347946-i6kx3n6m 538 50 the the DT cord-347946-i6kx3n6m 538 51 immune immune JJ cord-347946-i6kx3n6m 538 52 system system NN cord-347946-i6kx3n6m 538 53 : : : cord-347946-i6kx3n6m 538 54 mammalian mammalian JJ cord-347946-i6kx3n6m 538 55 sleep sleep NN cord-347946-i6kx3n6m 538 56 and and CC cord-347946-i6kx3n6m 538 57 resistance resistance NN cord-347946-i6kx3n6m 538 58 to to IN cord-347946-i6kx3n6m 538 59 parasites parasite NNS cord-347946-i6kx3n6m 538 60 Sirtuin Sirtuin NNP cord-347946-i6kx3n6m 538 61 1 1 CD cord-347946-i6kx3n6m 538 62 regulates regulate VBZ cord-347946-i6kx3n6m 538 63 dendritic dendritic JJ cord-347946-i6kx3n6m 538 64 cell cell NN cord-347946-i6kx3n6m 538 65 activation activation NN cord-347946-i6kx3n6m 538 66 and and CC cord-347946-i6kx3n6m 538 67 autophagy autophagy NN cord-347946-i6kx3n6m 538 68 during during IN cord-347946-i6kx3n6m 538 69 respiratory respiratory JJ cord-347946-i6kx3n6m 538 70 syncytial syncytial JJ cord-347946-i6kx3n6m 538 71 virus virus NN cord-347946-i6kx3n6m 538 72 - - HYPH cord-347946-i6kx3n6m 538 73 induced induce VBN cord-347946-i6kx3n6m 538 74 immune immune JJ cord-347946-i6kx3n6m 538 75 responses response NNS cord-347946-i6kx3n6m 539 1 Increased increase VBN cord-347946-i6kx3n6m 539 2 stress stress NN cord-347946-i6kx3n6m 539 3 - - HYPH cord-347946-i6kx3n6m 539 4 induced induce VBN cord-347946-i6kx3n6m 539 5 inflammatory inflammatory JJ cord-347946-i6kx3n6m 539 6 responses response NNS cord-347946-i6kx3n6m 539 7 in in IN cord-347946-i6kx3n6m 539 8 male male JJ cord-347946-i6kx3n6m 539 9 patients patient NNS cord-347946-i6kx3n6m 539 10 with with IN cord-347946-i6kx3n6m 539 11 major major JJ cord-347946-i6kx3n6m 539 12 depression depression NN cord-347946-i6kx3n6m 539 13 and and CC cord-347946-i6kx3n6m 539 14 increased increase VBD cord-347946-i6kx3n6m 539 15 early early JJ cord-347946-i6kx3n6m 539 16 life life NN cord-347946-i6kx3n6m 539 17 stress stress NN cord-347946-i6kx3n6m 539 18 Increased increase VBD cord-347946-i6kx3n6m 539 19 stress stress NN cord-347946-i6kx3n6m 539 20 - - HYPH cord-347946-i6kx3n6m 539 21 induced induce VBN cord-347946-i6kx3n6m 539 22 inflammatory inflammatory JJ cord-347946-i6kx3n6m 539 23 responses response NNS cord-347946-i6kx3n6m 539 24 in in IN cord-347946-i6kx3n6m 539 25 male male JJ cord-347946-i6kx3n6m 539 26 patients patient NNS cord-347946-i6kx3n6m 539 27 with with IN cord-347946-i6kx3n6m 539 28 major major JJ cord-347946-i6kx3n6m 539 29 depression depression NN cord-347946-i6kx3n6m 539 30 and and CC cord-347946-i6kx3n6m 539 31 increased increase VBD cord-347946-i6kx3n6m 539 32 early early JJ cord-347946-i6kx3n6m 539 33 life life NN cord-347946-i6kx3n6m 539 34 stress stress NN cord-347946-i6kx3n6m 539 35 IFNG IFNG NNP cord-347946-i6kx3n6m 540 1 +874 +874 NNP cord-347946-i6kx3n6m 540 2 T T NNP cord-347946-i6kx3n6m 540 3 / / SYM cord-347946-i6kx3n6m 540 4 A A NNP cord-347946-i6kx3n6m 540 5 , , , cord-347946-i6kx3n6m 540 6 IL10 IL10 NNP cord-347946-i6kx3n6m 540 7 -1082 -1082 HYPH cord-347946-i6kx3n6m 540 8 G G NNP cord-347946-i6kx3n6m 541 1 /A /A NNP cord-347946-i6kx3n6m 541 2 and and CC cord-347946-i6kx3n6m 542 1 TNF TNF NNP cord-347946-i6kx3n6m 542 2 -308 -308 HYPH cord-347946-i6kx3n6m 542 3 G G NNP cord-347946-i6kx3n6m 543 1 / / NFP cord-347946-i6kx3n6m 544 1 A a DT cord-347946-i6kx3n6m 544 2 polymorphisms polymorphism NNS cord-347946-i6kx3n6m 544 3 in in IN cord-347946-i6kx3n6m 544 4 association association NN cord-347946-i6kx3n6m 544 5 with with IN cord-347946-i6kx3n6m 544 6 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 544 7 susceptibility susceptibility NN cord-347946-i6kx3n6m 545 1 : : : cord-347946-i6kx3n6m 545 2 a a DT cord-347946-i6kx3n6m 545 3 meta meta JJ cord-347946-i6kx3n6m 545 4 - - HYPH cord-347946-i6kx3n6m 545 5 analysis analysis NN cord-347946-i6kx3n6m 545 6 study study NN cord-347946-i6kx3n6m 545 7 SIRT1 SIRT1 NNP cord-347946-i6kx3n6m 545 8 inhibits inhibit VBZ cord-347946-i6kx3n6m 545 9 differentiation differentiation NN cord-347946-i6kx3n6m 545 10 of of IN cord-347946-i6kx3n6m 545 11 monocytes monocyte NNS cord-347946-i6kx3n6m 545 12 to to IN cord-347946-i6kx3n6m 545 13 macrophages macrophage NNS cord-347946-i6kx3n6m 545 14 : : : cord-347946-i6kx3n6m 546 1 amelioration amelioration NN cord-347946-i6kx3n6m 546 2 of of IN cord-347946-i6kx3n6m 546 3 synovial synovial JJ cord-347946-i6kx3n6m 546 4 inflammation inflammation NN cord-347946-i6kx3n6m 546 5 in in IN cord-347946-i6kx3n6m 546 6 rheumatoid rheumatoid NN cord-347946-i6kx3n6m 546 7 arthritis arthritis NN cord-347946-i6kx3n6m 546 8 Leptin Leptin NNP cord-347946-i6kx3n6m 546 9 in in IN cord-347946-i6kx3n6m 546 10 depressed depressed JJ cord-347946-i6kx3n6m 546 11 women woman NNS cord-347946-i6kx3n6m 546 12 : : : cord-347946-i6kx3n6m 546 13 cross cross JJ cord-347946-i6kx3n6m 546 14 - - JJ cord-347946-i6kx3n6m 546 15 sectional sectional JJ cord-347946-i6kx3n6m 546 16 and and CC cord-347946-i6kx3n6m 546 17 longitudinal longitudinal JJ cord-347946-i6kx3n6m 546 18 data datum NNS cord-347946-i6kx3n6m 546 19 from from IN cord-347946-i6kx3n6m 546 20 an an DT cord-347946-i6kx3n6m 546 21 epidemiologic epidemiologic JJ cord-347946-i6kx3n6m 546 22 study study NN cord-347946-i6kx3n6m 546 23 Sleep sleep NN cord-347946-i6kx3n6m 546 24 duration duration NN cord-347946-i6kx3n6m 546 25 and and CC cord-347946-i6kx3n6m 546 26 biomarkers biomarker NNS cord-347946-i6kx3n6m 546 27 of of IN cord-347946-i6kx3n6m 546 28 inflammation inflammation NN cord-347946-i6kx3n6m 546 29 Descriptive descriptive JJ cord-347946-i6kx3n6m 546 30 epidemiology epidemiology NN cord-347946-i6kx3n6m 546 31 of of IN cord-347946-i6kx3n6m 546 32 major major JJ cord-347946-i6kx3n6m 546 33 depression depression NN cord-347946-i6kx3n6m 546 34 in in IN cord-347946-i6kx3n6m 546 35 Canada Canada NNP cord-347946-i6kx3n6m 546 36 Association Association NNP cord-347946-i6kx3n6m 546 37 of of IN cord-347946-i6kx3n6m 546 38 body body NNP cord-347946-i6kx3n6m 546 39 mass mass NNP cord-347946-i6kx3n6m 546 40 index index NN cord-347946-i6kx3n6m 546 41 with with IN cord-347946-i6kx3n6m 546 42 all all DT cord-347946-i6kx3n6m 546 43 - - HYPH cord-347946-i6kx3n6m 546 44 cause cause NN cord-347946-i6kx3n6m 546 45 and and CC cord-347946-i6kx3n6m 546 46 cause cause NN cord-347946-i6kx3n6m 546 47 - - HYPH cord-347946-i6kx3n6m 546 48 specific specific JJ cord-347946-i6kx3n6m 546 49 mortality mortality NN cord-347946-i6kx3n6m 546 50 : : : cord-347946-i6kx3n6m 546 51 findings finding NNS cord-347946-i6kx3n6m 546 52 from from IN cord-347946-i6kx3n6m 546 53 a a DT cord-347946-i6kx3n6m 546 54 prospective prospective JJ cord-347946-i6kx3n6m 546 55 cohort cohort NN cord-347946-i6kx3n6m 546 56 study study NN cord-347946-i6kx3n6m 546 57 in in IN cord-347946-i6kx3n6m 546 58 Mumbai Mumbai NNP cord-347946-i6kx3n6m 546 59 Initial initial JJ cord-347946-i6kx3n6m 546 60 evidence evidence NN cord-347946-i6kx3n6m 546 61 for for IN cord-347946-i6kx3n6m 546 62 the the DT cord-347946-i6kx3n6m 546 63 role role NN cord-347946-i6kx3n6m 546 64 of of IN cord-347946-i6kx3n6m 546 65 CACNA1C CACNA1C NNP cord-347946-i6kx3n6m 546 66 on on IN cord-347946-i6kx3n6m 546 67 subcortical subcortical JJ cord-347946-i6kx3n6m 546 68 brain brain NN cord-347946-i6kx3n6m 546 69 morphology morphology NN cord-347946-i6kx3n6m 546 70 in in IN cord-347946-i6kx3n6m 546 71 patients patient NNS cord-347946-i6kx3n6m 546 72 with with IN cord-347946-i6kx3n6m 546 73 bipolar bipolar JJ cord-347946-i6kx3n6m 546 74 disorder disorder NN cord-347946-i6kx3n6m 547 1 The the DT cord-347946-i6kx3n6m 547 2 better well JJR cord-347946-i6kx3n6m 547 3 angels angel NNS cord-347946-i6kx3n6m 547 4 of of IN cord-347946-i6kx3n6m 547 5 our -PRON- PRP$ cord-347946-i6kx3n6m 547 6 nature nature NN cord-347946-i6kx3n6m 547 7 : : : cord-347946-i6kx3n6m 547 8 why why WRB cord-347946-i6kx3n6m 547 9 violence violence NN cord-347946-i6kx3n6m 547 10 has have VBZ cord-347946-i6kx3n6m 547 11 declined decline VBN cord-347946-i6kx3n6m 547 12 T T NNP cord-347946-i6kx3n6m 547 13 helper helper NN cord-347946-i6kx3n6m 547 14 1 1 CD cord-347946-i6kx3n6m 547 15 / / SYM cord-347946-i6kx3n6m 547 16 T t NN cord-347946-i6kx3n6m 547 17 helper helper NN cord-347946-i6kx3n6m 547 18 2 2 CD cord-347946-i6kx3n6m 547 19 cytokine cytokine NN cord-347946-i6kx3n6m 547 20 imbalance imbalance NN cord-347946-i6kx3n6m 547 21 in in IN cord-347946-i6kx3n6m 547 22 respiratory respiratory JJ cord-347946-i6kx3n6m 547 23 syncytial syncytial JJ cord-347946-i6kx3n6m 547 24 virus virus NN cord-347946-i6kx3n6m 547 25 infection infection NN cord-347946-i6kx3n6m 547 26 is be VBZ cord-347946-i6kx3n6m 547 27 associated associate VBN cord-347946-i6kx3n6m 547 28 with with IN cord-347946-i6kx3n6m 547 29 increased increase VBN cord-347946-i6kx3n6m 547 30 endogenous endogenous JJ cord-347946-i6kx3n6m 547 31 plasma plasma NN cord-347946-i6kx3n6m 547 32 cortisol cortisol NN cord-347946-i6kx3n6m 547 33 Increased increase VBN cord-347946-i6kx3n6m 547 34 neural neural JJ cord-347946-i6kx3n6m 547 35 cell cell NN cord-347946-i6kx3n6m 547 36 adhesion adhesion NN cord-347946-i6kx3n6m 547 37 molecule molecule NN cord-347946-i6kx3n6m 547 38 in in IN cord-347946-i6kx3n6m 547 39 the the DT cord-347946-i6kx3n6m 547 40 CSF CSF NNP cord-347946-i6kx3n6m 547 41 of of IN cord-347946-i6kx3n6m 547 42 patients patient NNS cord-347946-i6kx3n6m 547 43 with with IN cord-347946-i6kx3n6m 547 44 mood mood NN cord-347946-i6kx3n6m 547 45 disorder disorder NN cord-347946-i6kx3n6m 548 1 Hypothalamic Hypothalamic NNP cord-347946-i6kx3n6m 548 2 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 548 3 lipid lipid NN cord-347946-i6kx3n6m 548 4 accumulation accumulation NN cord-347946-i6kx3n6m 548 5 , , , cord-347946-i6kx3n6m 548 6 inflammation inflammation NN cord-347946-i6kx3n6m 548 7 , , , cord-347946-i6kx3n6m 548 8 and and CC cord-347946-i6kx3n6m 548 9 insulin insulin NN cord-347946-i6kx3n6m 548 10 resistance resistance NN cord-347946-i6kx3n6m 548 11 in in IN cord-347946-i6kx3n6m 548 12 rats rat NNS cord-347946-i6kx3n6m 548 13 fed feed VBD cord-347946-i6kx3n6m 548 14 a a DT cord-347946-i6kx3n6m 548 15 high high JJ cord-347946-i6kx3n6m 548 16 - - HYPH cord-347946-i6kx3n6m 548 17 fat fat NN cord-347946-i6kx3n6m 548 18 diet diet NN cord-347946-i6kx3n6m 548 19 Symptoms symptom NNS cord-347946-i6kx3n6m 548 20 of of IN cord-347946-i6kx3n6m 548 21 atypical atypical JJ cord-347946-i6kx3n6m 548 22 depression depression NN cord-347946-i6kx3n6m 548 23 Immunogenic immunogenic JJ cord-347946-i6kx3n6m 548 24 dendritic dendritic JJ cord-347946-i6kx3n6m 548 25 cells cell NNS cord-347946-i6kx3n6m 548 26 primed prime VBN cord-347946-i6kx3n6m 548 27 by by IN cord-347946-i6kx3n6m 548 28 social social JJ cord-347946-i6kx3n6m 548 29 defeat defeat NN cord-347946-i6kx3n6m 548 30 enhance enhance VB cord-347946-i6kx3n6m 548 31 adaptive adaptive JJ cord-347946-i6kx3n6m 548 32 immunity immunity NN cord-347946-i6kx3n6m 548 33 to to TO cord-347946-i6kx3n6m 548 34 influenza influenza NN cord-347946-i6kx3n6m 548 35 A a DT cord-347946-i6kx3n6m 548 36 virus virus NN cord-347946-i6kx3n6m 548 37 Cytokine cytokine NN cord-347946-i6kx3n6m 548 38 - - HYPH cord-347946-i6kx3n6m 548 39 induced induce VBN cord-347946-i6kx3n6m 548 40 depression depression NN cord-347946-i6kx3n6m 548 41 during during IN cord-347946-i6kx3n6m 548 42 IFN IFN NNP cord-347946-i6kx3n6m 548 43 - - HYPH cord-347946-i6kx3n6m 548 44 alpha alpha NN cord-347946-i6kx3n6m 548 45 treatment treatment NN cord-347946-i6kx3n6m 548 46 : : : cord-347946-i6kx3n6m 549 1 The the DT cord-347946-i6kx3n6m 549 2 role role NN cord-347946-i6kx3n6m 549 3 of of IN cord-347946-i6kx3n6m 549 4 IL-6 IL-6 NNP cord-347946-i6kx3n6m 549 5 and and CC cord-347946-i6kx3n6m 549 6 sleep sleep VB cord-347946-i6kx3n6m 549 7 quality quality NN cord-347946-i6kx3n6m 549 8 Sleep sleep NN cord-347946-i6kx3n6m 549 9 duration duration NN cord-347946-i6kx3n6m 549 10 , , , cord-347946-i6kx3n6m 549 11 insomnia insomnia NN cord-347946-i6kx3n6m 549 12 , , , cord-347946-i6kx3n6m 549 13 and and CC cord-347946-i6kx3n6m 549 14 markers marker NNS cord-347946-i6kx3n6m 549 15 of of IN cord-347946-i6kx3n6m 549 16 systemic systemic JJ cord-347946-i6kx3n6m 549 17 inflammation inflammation NN cord-347946-i6kx3n6m 549 18 : : : cord-347946-i6kx3n6m 549 19 results result NNS cord-347946-i6kx3n6m 549 20 from from IN cord-347946-i6kx3n6m 549 21 the the DT cord-347946-i6kx3n6m 549 22 Netherlands Netherlands NNP cord-347946-i6kx3n6m 549 23 Study Study NNP cord-347946-i6kx3n6m 549 24 of of IN cord-347946-i6kx3n6m 549 25 Depression Depression NNP cord-347946-i6kx3n6m 549 26 and and CC cord-347946-i6kx3n6m 549 27 Anxiety Anxiety NNP cord-347946-i6kx3n6m 549 28 ( ( -LRB- cord-347946-i6kx3n6m 549 29 NESDA NESDA NNP cord-347946-i6kx3n6m 549 30 ) ) -RRB- cord-347946-i6kx3n6m 550 1 In in IN cord-347946-i6kx3n6m 550 2 vitro vitro FW cord-347946-i6kx3n6m 550 3 production production NN cord-347946-i6kx3n6m 550 4 of of IN cord-347946-i6kx3n6m 550 5 IFN IFN NNP cord-347946-i6kx3n6m 550 6 - - HYPH cord-347946-i6kx3n6m 550 7 gamma gamma NNP cord-347946-i6kx3n6m 550 8 correlates correlate VBZ cord-347946-i6kx3n6m 550 9 with with IN cord-347946-i6kx3n6m 550 10 CA CA NNP cord-347946-i6kx3n6m 550 11 repeat repeat VB cord-347946-i6kx3n6m 550 12 polymorphism polymorphism NN cord-347946-i6kx3n6m 550 13 in in IN cord-347946-i6kx3n6m 550 14 the the DT cord-347946-i6kx3n6m 550 15 human human JJ cord-347946-i6kx3n6m 550 16 IFN IFN NNP cord-347946-i6kx3n6m 550 17 - - HYPH cord-347946-i6kx3n6m 550 18 gamma gamma NN cord-347946-i6kx3n6m 550 19 gene gene NN cord-347946-i6kx3n6m 551 1 A a DT cord-347946-i6kx3n6m 551 2 single single JJ cord-347946-i6kx3n6m 551 3 nucleotide nucleotide JJ cord-347946-i6kx3n6m 551 4 polymorphism polymorphism NN cord-347946-i6kx3n6m 551 5 in in IN cord-347946-i6kx3n6m 551 6 the the DT cord-347946-i6kx3n6m 551 7 first first JJ cord-347946-i6kx3n6m 551 8 intron intron NN cord-347946-i6kx3n6m 551 9 of of IN cord-347946-i6kx3n6m 551 10 the the DT cord-347946-i6kx3n6m 551 11 human human JJ cord-347946-i6kx3n6m 551 12 IFN IFN NNP cord-347946-i6kx3n6m 551 13 - - HYPH cord-347946-i6kx3n6m 551 14 gamma gamma NN cord-347946-i6kx3n6m 551 15 gene gene NN cord-347946-i6kx3n6m 551 16 : : : cord-347946-i6kx3n6m 552 1 absolute absolute JJ cord-347946-i6kx3n6m 552 2 correlation correlation NN cord-347946-i6kx3n6m 552 3 with with IN cord-347946-i6kx3n6m 552 4 a a DT cord-347946-i6kx3n6m 552 5 polymorphic polymorphic JJ cord-347946-i6kx3n6m 552 6 CA CA NNP cord-347946-i6kx3n6m 552 7 microsatellite microsatellite JJ cord-347946-i6kx3n6m 552 8 marker marker NN cord-347946-i6kx3n6m 552 9 of of IN cord-347946-i6kx3n6m 552 10 high high JJ cord-347946-i6kx3n6m 552 11 IFN IFN NNP cord-347946-i6kx3n6m 552 12 - - HYPH cord-347946-i6kx3n6m 552 13 gamma gamma NN cord-347946-i6kx3n6m 552 14 production production NN cord-347946-i6kx3n6m 552 15 Social social JJ cord-347946-i6kx3n6m 552 16 stress stress NN cord-347946-i6kx3n6m 552 17 increases increase VBZ cord-347946-i6kx3n6m 552 18 the the DT cord-347946-i6kx3n6m 552 19 susceptibility susceptibility NN cord-347946-i6kx3n6m 552 20 to to IN cord-347946-i6kx3n6m 552 21 endotoxic endotoxic NNP cord-347946-i6kx3n6m 552 22 shock shock NN cord-347946-i6kx3n6m 552 23 Activation Activation NNP cord-347946-i6kx3n6m 552 24 of of IN cord-347946-i6kx3n6m 552 25 central central JJ cord-347946-i6kx3n6m 552 26 nervous nervous JJ cord-347946-i6kx3n6m 552 27 system system NN cord-347946-i6kx3n6m 552 28 inflammatory inflammatory JJ cord-347946-i6kx3n6m 552 29 pathways pathway NNS cord-347946-i6kx3n6m 552 30 by by IN cord-347946-i6kx3n6m 552 31 interferon interferon NN cord-347946-i6kx3n6m 552 32 - - HYPH cord-347946-i6kx3n6m 552 33 alpha alpha NN cord-347946-i6kx3n6m 552 34 : : : cord-347946-i6kx3n6m 552 35 relationship relationship NN cord-347946-i6kx3n6m 552 36 to to IN cord-347946-i6kx3n6m 552 37 monoamines monoamine NNS cord-347946-i6kx3n6m 552 38 and and CC cord-347946-i6kx3n6m 552 39 depression depression NN cord-347946-i6kx3n6m 552 40 Interferon interferon NN cord-347946-i6kx3n6m 552 41 - - HYPH cord-347946-i6kx3n6m 552 42 alpha alpha NN cord-347946-i6kx3n6m 552 43 effects effect NNS cord-347946-i6kx3n6m 552 44 on on IN cord-347946-i6kx3n6m 552 45 diurnal diurnal JJ cord-347946-i6kx3n6m 552 46 hypothalamic hypothalamic JJ cord-347946-i6kx3n6m 552 47 - - HYPH cord-347946-i6kx3n6m 552 48 pituitary pituitary NN cord-347946-i6kx3n6m 552 49 - - HYPH cord-347946-i6kx3n6m 552 50 adrenal adrenal NN cord-347946-i6kx3n6m 552 51 axis axis NN cord-347946-i6kx3n6m 552 52 activity activity NN cord-347946-i6kx3n6m 552 53 : : : cord-347946-i6kx3n6m 552 54 relationship relationship NN cord-347946-i6kx3n6m 552 55 with with IN cord-347946-i6kx3n6m 552 56 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 552 57 cytokines cytokine NNS cord-347946-i6kx3n6m 552 58 and and CC cord-347946-i6kx3n6m 552 59 behavior behavior NN cord-347946-i6kx3n6m 552 60 Depressive depressive JJ cord-347946-i6kx3n6m 552 61 symptoms symptom NNS cord-347946-i6kx3n6m 552 62 and and CC cord-347946-i6kx3n6m 552 63 viral viral JJ cord-347946-i6kx3n6m 552 64 clearance clearance NN cord-347946-i6kx3n6m 552 65 in in IN cord-347946-i6kx3n6m 552 66 patients patient NNS cord-347946-i6kx3n6m 552 67 receiving receive VBG cord-347946-i6kx3n6m 552 68 interferon interferon NN cord-347946-i6kx3n6m 552 69 - - HYPH cord-347946-i6kx3n6m 552 70 alpha alpha NN cord-347946-i6kx3n6m 552 71 and and CC cord-347946-i6kx3n6m 552 72 ribavirin ribavirin JJ cord-347946-i6kx3n6m 552 73 for for IN cord-347946-i6kx3n6m 552 74 hepatitis hepatitis NN cord-347946-i6kx3n6m 552 75 C C NNP cord-347946-i6kx3n6m 552 76 CSF CSF NNP cord-347946-i6kx3n6m 552 77 concentrations concentration NNS cord-347946-i6kx3n6m 552 78 of of IN cord-347946-i6kx3n6m 552 79 brain brain NN cord-347946-i6kx3n6m 552 80 tryptophan tryptophan NN cord-347946-i6kx3n6m 552 81 and and CC cord-347946-i6kx3n6m 552 82 kynurenines kynurenine NNS cord-347946-i6kx3n6m 552 83 during during IN cord-347946-i6kx3n6m 552 84 immune immune JJ cord-347946-i6kx3n6m 552 85 stimulation stimulation NN cord-347946-i6kx3n6m 552 86 with with IN cord-347946-i6kx3n6m 552 87 IFN IFN NNP cord-347946-i6kx3n6m 552 88 - - HYPH cord-347946-i6kx3n6m 552 89 alpha alpha NN cord-347946-i6kx3n6m 552 90 : : : cord-347946-i6kx3n6m 552 91 relationship relationship NN cord-347946-i6kx3n6m 552 92 to to IN cord-347946-i6kx3n6m 552 93 CNS CNS NNP cord-347946-i6kx3n6m 552 94 immune immune JJ cord-347946-i6kx3n6m 552 95 responses response NNS cord-347946-i6kx3n6m 552 96 and and CC cord-347946-i6kx3n6m 552 97 depression depression NN cord-347946-i6kx3n6m 552 98 Inflammation inflammation NN cord-347946-i6kx3n6m 552 99 , , , cord-347946-i6kx3n6m 552 100 sanitation sanitation NN cord-347946-i6kx3n6m 552 101 , , , cord-347946-i6kx3n6m 552 102 and and CC cord-347946-i6kx3n6m 552 103 consternation consternation NN cord-347946-i6kx3n6m 552 104 : : : cord-347946-i6kx3n6m 552 105 loss loss NN cord-347946-i6kx3n6m 552 106 of of IN cord-347946-i6kx3n6m 552 107 contact contact NN cord-347946-i6kx3n6m 552 108 with with IN cord-347946-i6kx3n6m 552 109 coevolved coevolve VBN cord-347946-i6kx3n6m 552 110 , , , cord-347946-i6kx3n6m 552 111 tolerogenic tolerogenic JJ cord-347946-i6kx3n6m 552 112 microorganisms microorganism NNS cord-347946-i6kx3n6m 552 113 and and CC cord-347946-i6kx3n6m 552 114 the the DT cord-347946-i6kx3n6m 552 115 pathophysiology pathophysiology NN cord-347946-i6kx3n6m 552 116 and and CC cord-347946-i6kx3n6m 552 117 treatment treatment NN cord-347946-i6kx3n6m 552 118 of of IN cord-347946-i6kx3n6m 552 119 major major JJ cord-347946-i6kx3n6m 552 120 depression depression NN cord-347946-i6kx3n6m 553 1 The the DT cord-347946-i6kx3n6m 553 2 evolutionary evolutionary JJ cord-347946-i6kx3n6m 553 3 significance significance NN cord-347946-i6kx3n6m 553 4 of of IN cord-347946-i6kx3n6m 553 5 depression depression NN cord-347946-i6kx3n6m 553 6 in in IN cord-347946-i6kx3n6m 553 7 Pathogen Pathogen NNP cord-347946-i6kx3n6m 553 8 Host Host NNP cord-347946-i6kx3n6m 553 9 Defense Defense NNP cord-347946-i6kx3n6m 553 10 ( ( -LRB- cord-347946-i6kx3n6m 553 11 PATHOS pathos NN cord-347946-i6kx3n6m 553 12 - - HYPH cord-347946-i6kx3n6m 553 13 D D NNP cord-347946-i6kx3n6m 553 14 ) ) -RRB- cord-347946-i6kx3n6m 553 15 . . . cord-347946-i6kx3n6m 554 1 Mol Mol NNP cord-347946-i6kx3n6m 554 2 Psychiatry Psychiatry NNP cord-347946-i6kx3n6m 554 3 Malaise Malaise NNP cord-347946-i6kx3n6m 554 4 , , , cord-347946-i6kx3n6m 554 5 melancholia melancholia NN cord-347946-i6kx3n6m 554 6 and and CC cord-347946-i6kx3n6m 554 7 madness madness NN cord-347946-i6kx3n6m 554 8 : : : cord-347946-i6kx3n6m 554 9 the the DT cord-347946-i6kx3n6m 554 10 evolutionary evolutionary JJ cord-347946-i6kx3n6m 554 11 legacy legacy NN cord-347946-i6kx3n6m 554 12 of of IN cord-347946-i6kx3n6m 554 13 an an DT cord-347946-i6kx3n6m 554 14 inflammatory inflammatory JJ cord-347946-i6kx3n6m 554 15 bias bias NN cord-347946-i6kx3n6m 554 16 Chronic Chronic NNP cord-347946-i6kx3n6m 554 17 interferon interferon NN cord-347946-i6kx3n6m 554 18 - - HYPH cord-347946-i6kx3n6m 554 19 alpha alpha NN cord-347946-i6kx3n6m 554 20 administration administration NN cord-347946-i6kx3n6m 554 21 disrupts disrupt VBZ cord-347946-i6kx3n6m 554 22 sleep sleep NN cord-347946-i6kx3n6m 554 23 continuity continuity NN cord-347946-i6kx3n6m 554 24 and and CC cord-347946-i6kx3n6m 554 25 depth depth NN cord-347946-i6kx3n6m 554 26 in in IN cord-347946-i6kx3n6m 554 27 patients patient NNS cord-347946-i6kx3n6m 554 28 with with IN cord-347946-i6kx3n6m 554 29 hepatitis hepatitis NNP cord-347946-i6kx3n6m 554 30 C C NNP cord-347946-i6kx3n6m 554 31 : : : cord-347946-i6kx3n6m 554 32 association association NN cord-347946-i6kx3n6m 554 33 with with IN cord-347946-i6kx3n6m 554 34 fatigue fatigue NN cord-347946-i6kx3n6m 554 35 , , , cord-347946-i6kx3n6m 554 36 motor motor NN cord-347946-i6kx3n6m 554 37 slowing slowing NN cord-347946-i6kx3n6m 554 38 , , , cord-347946-i6kx3n6m 554 39 and and CC cord-347946-i6kx3n6m 554 40 increased increase VBD cord-347946-i6kx3n6m 554 41 evening evening NN cord-347946-i6kx3n6m 554 42 cortisol cortisol NN cord-347946-i6kx3n6m 554 43 A a DT cord-347946-i6kx3n6m 554 44 bad bad JJ cord-347946-i6kx3n6m 554 45 case case NN cord-347946-i6kx3n6m 554 46 of of IN cord-347946-i6kx3n6m 554 47 the the DT cord-347946-i6kx3n6m 554 48 flu flu NN cord-347946-i6kx3n6m 554 49 ? ? . cord-347946-i6kx3n6m 555 1 The the DT cord-347946-i6kx3n6m 555 2 comparative comparative JJ cord-347946-i6kx3n6m 555 3 phenomenology phenomenology NN cord-347946-i6kx3n6m 555 4 of of IN cord-347946-i6kx3n6m 555 5 depression depression NN cord-347946-i6kx3n6m 555 6 and and CC cord-347946-i6kx3n6m 555 7 somatic somatic JJ cord-347946-i6kx3n6m 555 8 illness illness NN cord-347946-i6kx3n6m 556 1 Sirtuin Sirtuin NNP cord-347946-i6kx3n6m 556 2 1 1 CD cord-347946-i6kx3n6m 556 3 regulates regulate VBZ cord-347946-i6kx3n6m 556 4 hepatitis hepatitis NN cord-347946-i6kx3n6m 556 5 B b NN cord-347946-i6kx3n6m 556 6 virus virus NN cord-347946-i6kx3n6m 556 7 transcription transcription NN cord-347946-i6kx3n6m 556 8 and and CC cord-347946-i6kx3n6m 556 9 replication replication NN cord-347946-i6kx3n6m 556 10 by by IN cord-347946-i6kx3n6m 556 11 targeting target VBG cord-347946-i6kx3n6m 556 12 transcription transcription NN cord-347946-i6kx3n6m 556 13 factor factor NN cord-347946-i6kx3n6m 556 14 AP-1 AP-1 NNP cord-347946-i6kx3n6m 557 1 Surgical surgical JJ cord-347946-i6kx3n6m 557 2 stress stress NN cord-347946-i6kx3n6m 557 3 - - HYPH cord-347946-i6kx3n6m 557 4 induced induce VBN cord-347946-i6kx3n6m 557 5 immune immune JJ cord-347946-i6kx3n6m 557 6 cell cell NN cord-347946-i6kx3n6m 557 7 redistribution redistribution NN cord-347946-i6kx3n6m 557 8 profiles profile NNS cord-347946-i6kx3n6m 557 9 predict predict VBP cord-347946-i6kx3n6m 557 10 short short JJ cord-347946-i6kx3n6m 557 11 - - HYPH cord-347946-i6kx3n6m 557 12 term term NN cord-347946-i6kx3n6m 557 13 and and CC cord-347946-i6kx3n6m 557 14 long long JJ cord-347946-i6kx3n6m 557 15 - - HYPH cord-347946-i6kx3n6m 557 16 term term NN cord-347946-i6kx3n6m 557 17 postsurgical postsurgical JJ cord-347946-i6kx3n6m 557 18 recovery recovery NN cord-347946-i6kx3n6m 557 19 . . . cord-347946-i6kx3n6m 558 1 A a DT cord-347946-i6kx3n6m 558 2 prospective prospective JJ cord-347946-i6kx3n6m 558 3 study study NN cord-347946-i6kx3n6m 559 1 The the DT cord-347946-i6kx3n6m 559 2 influence influence NN cord-347946-i6kx3n6m 559 3 of of IN cord-347946-i6kx3n6m 559 4 captive captive JJ cord-347946-i6kx3n6m 559 5 adolescent adolescent JJ cord-347946-i6kx3n6m 559 6 male male JJ cord-347946-i6kx3n6m 559 7 chimpanzees chimpanzee NNS cord-347946-i6kx3n6m 559 8 on on IN cord-347946-i6kx3n6m 559 9 wounding wounding NN cord-347946-i6kx3n6m 559 10 : : : cord-347946-i6kx3n6m 559 11 management management NN cord-347946-i6kx3n6m 559 12 and and CC cord-347946-i6kx3n6m 559 13 welfare welfare NN cord-347946-i6kx3n6m 559 14 implications implication NNS cord-347946-i6kx3n6m 560 1 Evolutionary evolutionary JJ cord-347946-i6kx3n6m 560 2 speculation speculation NN cord-347946-i6kx3n6m 560 3 about about IN cord-347946-i6kx3n6m 560 4 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 560 5 and and CC cord-347946-i6kx3n6m 560 6 the the DT cord-347946-i6kx3n6m 560 7 metabolic metabolic JJ cord-347946-i6kx3n6m 560 8 and and CC cord-347946-i6kx3n6m 560 9 inflammatory inflammatory JJ cord-347946-i6kx3n6m 560 10 processes process NNS cord-347946-i6kx3n6m 560 11 of of IN cord-347946-i6kx3n6m 560 12 obesity obesity NN cord-347946-i6kx3n6m 560 13 Low low JJ cord-347946-i6kx3n6m 560 14 antibodies antibody NNS cord-347946-i6kx3n6m 560 15 against against IN cord-347946-i6kx3n6m 560 16 Plasmodium Plasmodium NNP cord-347946-i6kx3n6m 560 17 falciparum falciparum NNS cord-347946-i6kx3n6m 560 18 and and CC cord-347946-i6kx3n6m 560 19 imbalanced imbalanced JJ cord-347946-i6kx3n6m 560 20 proinflammatory proinflammatory JJ cord-347946-i6kx3n6m 560 21 cytokines cytokine NNS cord-347946-i6kx3n6m 560 22 are be VBP cord-347946-i6kx3n6m 560 23 associated associate VBN cord-347946-i6kx3n6m 560 24 with with IN cord-347946-i6kx3n6m 560 25 severe severe JJ cord-347946-i6kx3n6m 560 26 malaria malaria NN cord-347946-i6kx3n6m 560 27 in in IN cord-347946-i6kx3n6m 560 28 Mozambican mozambican JJ cord-347946-i6kx3n6m 560 29 children child NNS cord-347946-i6kx3n6m 560 30 : : : cord-347946-i6kx3n6m 560 31 a a DT cord-347946-i6kx3n6m 560 32 case case NN cord-347946-i6kx3n6m 560 33 - - HYPH cord-347946-i6kx3n6m 560 34 control control NN cord-347946-i6kx3n6m 560 35 study study NN cord-347946-i6kx3n6m 560 36 Sexual sexual JJ cord-347946-i6kx3n6m 560 37 diergism diergism NN cord-347946-i6kx3n6m 560 38 of of IN cord-347946-i6kx3n6m 560 39 baseline baseline JJ cord-347946-i6kx3n6m 560 40 plasma plasma NN cord-347946-i6kx3n6m 560 41 leptin leptin NN cord-347946-i6kx3n6m 560 42 and and CC cord-347946-i6kx3n6m 560 43 leptin leptin NN cord-347946-i6kx3n6m 560 44 suppression suppression NN cord-347946-i6kx3n6m 560 45 by by IN cord-347946-i6kx3n6m 560 46 arginine arginine NN cord-347946-i6kx3n6m 560 47 vasopressin vasopressin NN cord-347946-i6kx3n6m 560 48 in in IN cord-347946-i6kx3n6m 560 49 major major JJ cord-347946-i6kx3n6m 560 50 depressives depressive NNS cord-347946-i6kx3n6m 560 51 and and CC cord-347946-i6kx3n6m 560 52 matched match VBN cord-347946-i6kx3n6m 560 53 controls control VBZ cord-347946-i6kx3n6m 560 54 The the DT cord-347946-i6kx3n6m 560 55 behavioural behavioural JJ cord-347946-i6kx3n6m 560 56 immune immune JJ cord-347946-i6kx3n6m 560 57 system system NN cord-347946-i6kx3n6m 560 58 and and CC cord-347946-i6kx3n6m 560 59 the the DT cord-347946-i6kx3n6m 560 60 psychology psychology NN cord-347946-i6kx3n6m 560 61 of of IN cord-347946-i6kx3n6m 560 62 human human JJ cord-347946-i6kx3n6m 560 63 sociality sociality NN cord-347946-i6kx3n6m 561 1 Mere mere JJ cord-347946-i6kx3n6m 561 2 visual visual JJ cord-347946-i6kx3n6m 561 3 perception perception NN cord-347946-i6kx3n6m 561 4 of of IN cord-347946-i6kx3n6m 561 5 other other JJ cord-347946-i6kx3n6m 561 6 people people NNS cord-347946-i6kx3n6m 561 7 's 's POS cord-347946-i6kx3n6m 561 8 disease disease NN cord-347946-i6kx3n6m 561 9 symptoms symptom NNS cord-347946-i6kx3n6m 561 10 facilitates facilitate VBZ cord-347946-i6kx3n6m 561 11 a a DT cord-347946-i6kx3n6m 561 12 more more RBR cord-347946-i6kx3n6m 561 13 aggressive aggressive JJ cord-347946-i6kx3n6m 561 14 immune immune JJ cord-347946-i6kx3n6m 561 15 response response NN cord-347946-i6kx3n6m 561 16 Pathogens pathogen NNS cord-347946-i6kx3n6m 561 17 , , , cord-347946-i6kx3n6m 561 18 personality personality NN cord-347946-i6kx3n6m 561 19 , , , cord-347946-i6kx3n6m 561 20 and and CC cord-347946-i6kx3n6m 561 21 culture culture NN cord-347946-i6kx3n6m 561 22 : : : cord-347946-i6kx3n6m 561 23 disease disease NN cord-347946-i6kx3n6m 561 24 prevalence prevalence NN cord-347946-i6kx3n6m 561 25 predicts predict VBZ cord-347946-i6kx3n6m 561 26 worldwide worldwide JJ cord-347946-i6kx3n6m 561 27 variability variability NN cord-347946-i6kx3n6m 561 28 in in IN cord-347946-i6kx3n6m 561 29 sociosexuality sociosexuality NN cord-347946-i6kx3n6m 561 30 , , , cord-347946-i6kx3n6m 561 31 extraversion extraversion NN cord-347946-i6kx3n6m 561 32 , , , cord-347946-i6kx3n6m 561 33 and and CC cord-347946-i6kx3n6m 561 34 openness openness NN cord-347946-i6kx3n6m 561 35 to to TO cord-347946-i6kx3n6m 561 36 experience experience VB cord-347946-i6kx3n6m 561 37 Combined combine VBN cord-347946-i6kx3n6m 561 38 dexamethasone dexamethasone NN cord-347946-i6kx3n6m 561 39 / / SYM cord-347946-i6kx3n6m 561 40 corticotropin corticotropin NN cord-347946-i6kx3n6m 561 41 - - HYPH cord-347946-i6kx3n6m 561 42 releasing release VBG cord-347946-i6kx3n6m 561 43 hormone hormone NN cord-347946-i6kx3n6m 561 44 test test NN cord-347946-i6kx3n6m 561 45 in in IN cord-347946-i6kx3n6m 561 46 acute acute JJ cord-347946-i6kx3n6m 561 47 and and CC cord-347946-i6kx3n6m 561 48 remitted remit VBD cord-347946-i6kx3n6m 561 49 manic manic JJ cord-347946-i6kx3n6m 561 50 patients patient NNS cord-347946-i6kx3n6m 561 51 , , , cord-347946-i6kx3n6m 561 52 in in IN cord-347946-i6kx3n6m 561 53 acute acute JJ cord-347946-i6kx3n6m 561 54 depression depression NN cord-347946-i6kx3n6m 561 55 , , , cord-347946-i6kx3n6m 561 56 and and CC cord-347946-i6kx3n6m 561 57 in in IN cord-347946-i6kx3n6m 561 58 normal normal JJ cord-347946-i6kx3n6m 561 59 controls control NNS cord-347946-i6kx3n6m 561 60 : : : cord-347946-i6kx3n6m 561 61 I -PRON- PRP cord-347946-i6kx3n6m 561 62 Who who WP cord-347946-i6kx3n6m 561 63 keeps keep VBZ cord-347946-i6kx3n6m 561 64 children child NNS cord-347946-i6kx3n6m 561 65 alive alive JJ cord-347946-i6kx3n6m 561 66 ? ? . cord-347946-i6kx3n6m 562 1 A a DT cord-347946-i6kx3n6m 562 2 review review NN cord-347946-i6kx3n6m 562 3 of of IN cord-347946-i6kx3n6m 562 4 the the DT cord-347946-i6kx3n6m 562 5 effects effect NNS cord-347946-i6kx3n6m 562 6 of of IN cord-347946-i6kx3n6m 562 7 kin kin NN cord-347946-i6kx3n6m 562 8 on on IN cord-347946-i6kx3n6m 562 9 child child NN cord-347946-i6kx3n6m 562 10 survival survival NN cord-347946-i6kx3n6m 562 11 Cross Cross NNP cord-347946-i6kx3n6m 562 12 - - JJ cord-347946-i6kx3n6m 562 13 national national JJ cord-347946-i6kx3n6m 562 14 associations association NNS cord-347946-i6kx3n6m 562 15 between between IN cord-347946-i6kx3n6m 562 16 gender gender NN cord-347946-i6kx3n6m 562 17 and and CC cord-347946-i6kx3n6m 562 18 mental mental JJ cord-347946-i6kx3n6m 562 19 disorders disorder NNS cord-347946-i6kx3n6m 562 20 in in IN cord-347946-i6kx3n6m 562 21 the the DT cord-347946-i6kx3n6m 562 22 World World NNP cord-347946-i6kx3n6m 562 23 Health Health NNP cord-347946-i6kx3n6m 562 24 Organization Organization NNP cord-347946-i6kx3n6m 562 25 World World NNP cord-347946-i6kx3n6m 562 26 Mental Mental NNP cord-347946-i6kx3n6m 562 27 Health Health NNP cord-347946-i6kx3n6m 562 28 Surveys Surveys NNPS cord-347946-i6kx3n6m 562 29 Preserving preserve VBG cord-347946-i6kx3n6m 562 30 immune immune JJ cord-347946-i6kx3n6m 562 31 diversity diversity NN cord-347946-i6kx3n6m 562 32 through through IN cord-347946-i6kx3n6m 562 33 ancient ancient JJ cord-347946-i6kx3n6m 562 34 inheritance inheritance NN cord-347946-i6kx3n6m 562 35 and and CC cord-347946-i6kx3n6m 562 36 admixture admixture NN cord-347946-i6kx3n6m 562 37 Altered altered JJ cord-347946-i6kx3n6m 562 38 expression expression NN cord-347946-i6kx3n6m 562 39 of of IN cord-347946-i6kx3n6m 562 40 genes gene NNS cord-347946-i6kx3n6m 562 41 involved involve VBN cord-347946-i6kx3n6m 562 42 in in IN cord-347946-i6kx3n6m 562 43 inflammation inflammation NN cord-347946-i6kx3n6m 562 44 and and CC cord-347946-i6kx3n6m 562 45 apoptosis apoptosis NN cord-347946-i6kx3n6m 562 46 in in IN cord-347946-i6kx3n6m 562 47 frontal frontal JJ cord-347946-i6kx3n6m 562 48 cortex cortex NN cord-347946-i6kx3n6m 562 49 in in IN cord-347946-i6kx3n6m 562 50 major major JJ cord-347946-i6kx3n6m 562 51 depression depression NN cord-347946-i6kx3n6m 563 1 The the DT cord-347946-i6kx3n6m 563 2 phenotypic phenotypic JJ cord-347946-i6kx3n6m 563 3 legacy legacy NN cord-347946-i6kx3n6m 563 4 of of IN cord-347946-i6kx3n6m 563 5 admixture admixture NN cord-347946-i6kx3n6m 563 6 between between IN cord-347946-i6kx3n6m 563 7 modern modern JJ cord-347946-i6kx3n6m 563 8 humans human NNS cord-347946-i6kx3n6m 563 9 and and CC cord-347946-i6kx3n6m 563 10 Neandertals Neandertals NNPS cord-347946-i6kx3n6m 563 11 Biochemical biochemical JJ cord-347946-i6kx3n6m 563 12 indices index NNS cord-347946-i6kx3n6m 563 13 of of IN cord-347946-i6kx3n6m 563 14 selected select VBN cord-347946-i6kx3n6m 563 15 trace trace NN cord-347946-i6kx3n6m 563 16 minerals mineral NNS cord-347946-i6kx3n6m 563 17 in in IN cord-347946-i6kx3n6m 563 18 men man NNS cord-347946-i6kx3n6m 563 19 : : : cord-347946-i6kx3n6m 563 20 effect effect NN cord-347946-i6kx3n6m 563 21 of of IN cord-347946-i6kx3n6m 563 22 stress stress NN cord-347946-i6kx3n6m 564 1 The the DT cord-347946-i6kx3n6m 564 2 emerging emerge VBG cord-347946-i6kx3n6m 564 3 field field NN cord-347946-i6kx3n6m 564 4 of of IN cord-347946-i6kx3n6m 564 5 human human JJ cord-347946-i6kx3n6m 564 6 social social JJ cord-347946-i6kx3n6m 564 7 genomics genomic NNS cord-347946-i6kx3n6m 564 8 Neural neural JJ cord-347946-i6kx3n6m 564 9 sensitivity sensitivity NN cord-347946-i6kx3n6m 564 10 to to IN cord-347946-i6kx3n6m 564 11 social social JJ cord-347946-i6kx3n6m 564 12 rejection rejection NN cord-347946-i6kx3n6m 564 13 is be VBZ cord-347946-i6kx3n6m 564 14 associated associate VBN cord-347946-i6kx3n6m 564 15 with with IN cord-347946-i6kx3n6m 564 16 inflammatory inflammatory JJ cord-347946-i6kx3n6m 564 17 responses response NNS cord-347946-i6kx3n6m 564 18 to to IN cord-347946-i6kx3n6m 564 19 social social JJ cord-347946-i6kx3n6m 564 20 stress stress NN cord-347946-i6kx3n6m 564 21 Indicators indicator NNS cord-347946-i6kx3n6m 564 22 of of IN cord-347946-i6kx3n6m 564 23 immune immune JJ cord-347946-i6kx3n6m 564 24 activation activation NN cord-347946-i6kx3n6m 564 25 in in IN cord-347946-i6kx3n6m 564 26 major major JJ cord-347946-i6kx3n6m 564 27 depression depression NN cord-347946-i6kx3n6m 564 28 Differences difference NNS cord-347946-i6kx3n6m 564 29 in in IN cord-347946-i6kx3n6m 564 30 depressive depressive JJ cord-347946-i6kx3n6m 564 31 symptom symptom NN cord-347946-i6kx3n6m 564 32 profile profile NN cord-347946-i6kx3n6m 564 33 between between IN cord-347946-i6kx3n6m 564 34 males male NNS cord-347946-i6kx3n6m 564 35 and and CC cord-347946-i6kx3n6m 564 36 females female NNS cord-347946-i6kx3n6m 565 1 The the DT cord-347946-i6kx3n6m 565 2 inflammatory inflammatory JJ cord-347946-i6kx3n6m 565 3 response response NN cord-347946-i6kx3n6m 565 4 system system NN cord-347946-i6kx3n6m 565 5 and and CC cord-347946-i6kx3n6m 565 6 the the DT cord-347946-i6kx3n6m 565 7 availability availability NN cord-347946-i6kx3n6m 565 8 of of IN cord-347946-i6kx3n6m 565 9 plasma plasma NN cord-347946-i6kx3n6m 565 10 tryptophan tryptophan NN cord-347946-i6kx3n6m 565 11 in in IN cord-347946-i6kx3n6m 565 12 patients patient NNS cord-347946-i6kx3n6m 565 13 with with IN cord-347946-i6kx3n6m 565 14 primary primary JJ cord-347946-i6kx3n6m 565 15 sleep sleep NN cord-347946-i6kx3n6m 565 16 disorders disorder NNS cord-347946-i6kx3n6m 565 17 and and CC cord-347946-i6kx3n6m 565 18 major major JJ cord-347946-i6kx3n6m 565 19 depression depression NN cord-347946-i6kx3n6m 565 20 Beta beta NN cord-347946-i6kx3n6m 565 21 - - HYPH cord-347946-i6kx3n6m 565 22 adrenoceptor adrenoceptor NN cord-347946-i6kx3n6m 565 23 antagonists antagonist NNS cord-347946-i6kx3n6m 565 24 suppress suppress VBP cord-347946-i6kx3n6m 565 25 elevation elevation NN cord-347946-i6kx3n6m 565 26 in in IN cord-347946-i6kx3n6m 565 27 body body NN cord-347946-i6kx3n6m 565 28 temperature temperature NN cord-347946-i6kx3n6m 565 29 and and CC cord-347946-i6kx3n6m 565 30 increase increase NN cord-347946-i6kx3n6m 565 31 in in IN cord-347946-i6kx3n6m 565 32 plasma plasma NN cord-347946-i6kx3n6m 565 33 IL-6 IL-6 NNP cord-347946-i6kx3n6m 565 34 in in IN cord-347946-i6kx3n6m 565 35 rats rat NNS cord-347946-i6kx3n6m 565 36 exposed expose VBN cord-347946-i6kx3n6m 565 37 to to IN cord-347946-i6kx3n6m 565 38 open open JJ cord-347946-i6kx3n6m 565 39 field field NN cord-347946-i6kx3n6m 566 1 The the DT cord-347946-i6kx3n6m 566 2 evolution evolution NN cord-347946-i6kx3n6m 566 3 of of IN cord-347946-i6kx3n6m 566 4 an an DT cord-347946-i6kx3n6m 566 5 ostracism ostracism NN cord-347946-i6kx3n6m 566 6 detection detection NN cord-347946-i6kx3n6m 566 7 system system NN cord-347946-i6kx3n6m 567 1 The the DT cord-347946-i6kx3n6m 567 2 relationship relationship NN cord-347946-i6kx3n6m 567 3 between between IN cord-347946-i6kx3n6m 567 4 post post JJ cord-347946-i6kx3n6m 567 5 - - JJ cord-347946-i6kx3n6m 567 6 natal natal JJ cord-347946-i6kx3n6m 567 7 depression depression NN cord-347946-i6kx3n6m 567 8 and and CC cord-347946-i6kx3n6m 567 9 mother mother NN cord-347946-i6kx3n6m 567 10 - - HYPH cord-347946-i6kx3n6m 567 11 child child NN cord-347946-i6kx3n6m 567 12 interaction interaction NN cord-347946-i6kx3n6m 567 13 The the DT cord-347946-i6kx3n6m 567 14 effect effect NN cord-347946-i6kx3n6m 567 15 of of IN cord-347946-i6kx3n6m 567 16 acute acute JJ cord-347946-i6kx3n6m 567 17 psychological psychological JJ cord-347946-i6kx3n6m 567 18 stress stress NN cord-347946-i6kx3n6m 567 19 on on IN cord-347946-i6kx3n6m 567 20 circulating circulate VBG cord-347946-i6kx3n6m 567 21 inflammatory inflammatory JJ cord-347946-i6kx3n6m 567 22 factors factor NNS cord-347946-i6kx3n6m 567 23 in in IN cord-347946-i6kx3n6m 567 24 humans human NNS cord-347946-i6kx3n6m 567 25 : : : cord-347946-i6kx3n6m 567 26 a a DT cord-347946-i6kx3n6m 567 27 review review NN cord-347946-i6kx3n6m 567 28 and and CC cord-347946-i6kx3n6m 567 29 meta meta NNP cord-347946-i6kx3n6m 567 30 - - HYPH cord-347946-i6kx3n6m 567 31 analysis analysis NN cord-347946-i6kx3n6m 567 32 Functional functional JJ cord-347946-i6kx3n6m 567 33 disability disability NN cord-347946-i6kx3n6m 567 34 and and CC cord-347946-i6kx3n6m 567 35 social social JJ cord-347946-i6kx3n6m 567 36 conflict conflict NN cord-347946-i6kx3n6m 567 37 increase increase NN cord-347946-i6kx3n6m 567 38 risk risk NN cord-347946-i6kx3n6m 567 39 of of IN cord-347946-i6kx3n6m 567 40 depression depression NN cord-347946-i6kx3n6m 567 41 in in IN cord-347946-i6kx3n6m 567 42 older old JJR cord-347946-i6kx3n6m 567 43 adulthood adulthood NN cord-347946-i6kx3n6m 567 44 among among IN cord-347946-i6kx3n6m 567 45 bolivian bolivian JJ cord-347946-i6kx3n6m 567 46 forager forager NN cord-347946-i6kx3n6m 567 47 - - HYPH cord-347946-i6kx3n6m 567 48 farmers farmer NNS cord-347946-i6kx3n6m 567 49 Depression Depression NNP cord-347946-i6kx3n6m 567 50 as as IN cord-347946-i6kx3n6m 567 51 sickness sickness NN cord-347946-i6kx3n6m 567 52 behavior behavior NN cord-347946-i6kx3n6m 567 53 ? ? . cord-347946-i6kx3n6m 568 1 A a DT cord-347946-i6kx3n6m 568 2 test test NN cord-347946-i6kx3n6m 568 3 of of IN cord-347946-i6kx3n6m 568 4 the the DT cord-347946-i6kx3n6m 568 5 host host NN cord-347946-i6kx3n6m 568 6 defense defense NN cord-347946-i6kx3n6m 568 7 hypothesis hypothesis NN cord-347946-i6kx3n6m 568 8 in in IN cord-347946-i6kx3n6m 568 9 a a DT cord-347946-i6kx3n6m 568 10 high high JJ cord-347946-i6kx3n6m 568 11 pathogen pathogen NN cord-347946-i6kx3n6m 568 12 population population NN cord-347946-i6kx3n6m 568 13 SIRT1 SIRT1 NNP cord-347946-i6kx3n6m 568 14 suppresses suppress VBZ cord-347946-i6kx3n6m 568 15 human human JJ cord-347946-i6kx3n6m 568 16 T t NN cord-347946-i6kx3n6m 568 17 - - HYPH cord-347946-i6kx3n6m 568 18 cell cell NN cord-347946-i6kx3n6m 568 19 leukemia leukemia NN cord-347946-i6kx3n6m 568 20 virus virus NN cord-347946-i6kx3n6m 568 21 type type NN cord-347946-i6kx3n6m 568 22 1 1 CD cord-347946-i6kx3n6m 568 23 transcription transcription NN cord-347946-i6kx3n6m 568 24 Neural neural JJ cord-347946-i6kx3n6m 568 25 and and CC cord-347946-i6kx3n6m 568 26 behavioral behavioral JJ cord-347946-i6kx3n6m 568 27 responses response NNS cord-347946-i6kx3n6m 568 28 to to IN cord-347946-i6kx3n6m 568 29 low low JJ cord-347946-i6kx3n6m 568 30 - - HYPH cord-347946-i6kx3n6m 568 31 grade grade NN cord-347946-i6kx3n6m 568 32 inflammation inflammation NN cord-347946-i6kx3n6m 568 33 beta beta NN cord-347946-i6kx3n6m 568 34 - - HYPH cord-347946-i6kx3n6m 568 35 Adrenergic adrenergic NN cord-347946-i6kx3n6m 568 36 receptor receptor NN cord-347946-i6kx3n6m 568 37 mediated mediate VBD cord-347946-i6kx3n6m 568 38 increases increase NNS cord-347946-i6kx3n6m 568 39 in in IN cord-347946-i6kx3n6m 568 40 activation activation NN cord-347946-i6kx3n6m 568 41 and and CC cord-347946-i6kx3n6m 568 42 function function NN cord-347946-i6kx3n6m 568 43 of of IN cord-347946-i6kx3n6m 568 44 natural natural JJ cord-347946-i6kx3n6m 568 45 killer killer NN cord-347946-i6kx3n6m 568 46 cells cell NNS cord-347946-i6kx3n6m 568 47 following follow VBG cord-347946-i6kx3n6m 568 48 repeated repeat VBN cord-347946-i6kx3n6m 568 49 social social JJ cord-347946-i6kx3n6m 568 50 disruption disruption NN cord-347946-i6kx3n6m 568 51 Atypical atypical JJ cord-347946-i6kx3n6m 568 52 depression depression NN cord-347946-i6kx3n6m 568 53 : : : cord-347946-i6kx3n6m 568 54 useful useful JJ cord-347946-i6kx3n6m 568 55 concept concept NN cord-347946-i6kx3n6m 568 56 , , , cord-347946-i6kx3n6m 568 57 but but CC cord-347946-i6kx3n6m 568 58 it -PRON- PRP cord-347946-i6kx3n6m 568 59 's be VBZ cord-347946-i6kx3n6m 568 60 time time NN cord-347946-i6kx3n6m 568 61 to to TO cord-347946-i6kx3n6m 568 62 revise revise VB cord-347946-i6kx3n6m 568 63 the the DT cord-347946-i6kx3n6m 568 64 DSM DSM NNP cord-347946-i6kx3n6m 568 65 - - HYPH cord-347946-i6kx3n6m 568 66 IV IV NNP cord-347946-i6kx3n6m 568 67 criteria criteria VBZ cord-347946-i6kx3n6m 568 68 Parasites parasite NNS cord-347946-i6kx3n6m 568 69 , , , cord-347946-i6kx3n6m 568 70 democratization democratization NN cord-347946-i6kx3n6m 568 71 , , , cord-347946-i6kx3n6m 568 72 and and CC cord-347946-i6kx3n6m 568 73 the the DT cord-347946-i6kx3n6m 568 74 liberalization liberalization NN cord-347946-i6kx3n6m 568 75 of of IN cord-347946-i6kx3n6m 568 76 values value NNS cord-347946-i6kx3n6m 568 77 across across IN cord-347946-i6kx3n6m 568 78 contemporary contemporary JJ cord-347946-i6kx3n6m 568 79 countries country NNS cord-347946-i6kx3n6m 568 80 Role role NN cord-347946-i6kx3n6m 568 81 of of IN cord-347946-i6kx3n6m 568 82 the the DT cord-347946-i6kx3n6m 568 83 IFNG IFNG NNP cord-347946-i6kx3n6m 569 1 +874 +874 NNP cord-347946-i6kx3n6m 569 2 T/ T/ NNP cord-347946-i6kx3n6m 570 1 A a DT cord-347946-i6kx3n6m 570 2 polymorphism polymorphism NN cord-347946-i6kx3n6m 570 3 in in IN cord-347946-i6kx3n6m 570 4 Chagas Chagas NNP cord-347946-i6kx3n6m 570 5 disease disease NN cord-347946-i6kx3n6m 570 6 in in IN cord-347946-i6kx3n6m 570 7 a a DT cord-347946-i6kx3n6m 570 8 Colombian colombian JJ cord-347946-i6kx3n6m 570 9 population population NN cord-347946-i6kx3n6m 571 1 In in IN cord-347946-i6kx3n6m 571 2 : : : cord-347946-i6kx3n6m 571 3 Sexual Sexual NNP cord-347946-i6kx3n6m 571 4 Selection Selection NNP cord-347946-i6kx3n6m 571 5 and and CC cord-347946-i6kx3n6m 571 6 the the DT cord-347946-i6kx3n6m 571 7 Descent Descent NNP cord-347946-i6kx3n6m 571 8 of of IN cord-347946-i6kx3n6m 571 9 Man Man NNP cord-347946-i6kx3n6m 571 10 Interferon Interferon NNP cord-347946-i6kx3n6m 571 11 - - HYPH cord-347946-i6kx3n6m 571 12 induced induce VBN cord-347946-i6kx3n6m 571 13 depression depression NN cord-347946-i6kx3n6m 571 14 in in IN cord-347946-i6kx3n6m 571 15 chronic chronic JJ cord-347946-i6kx3n6m 571 16 hepatitis hepatitis NN cord-347946-i6kx3n6m 571 17 C c NN cord-347946-i6kx3n6m 571 18 : : : cord-347946-i6kx3n6m 571 19 a a DT cord-347946-i6kx3n6m 571 20 systematic systematic JJ cord-347946-i6kx3n6m 571 21 review review NN cord-347946-i6kx3n6m 571 22 and and CC cord-347946-i6kx3n6m 571 23 meta meta NNP cord-347946-i6kx3n6m 571 24 - - HYPH cord-347946-i6kx3n6m 571 25 analysis analysis NN cord-347946-i6kx3n6m 572 1 Sirtuins sirtuin NNS cord-347946-i6kx3n6m 572 2 link link VBP cord-347946-i6kx3n6m 572 3 inflammation inflammation NN cord-347946-i6kx3n6m 572 4 and and CC cord-347946-i6kx3n6m 572 5 metabolism metabolism NN cord-347946-i6kx3n6m 573 1 A a DT cord-347946-i6kx3n6m 573 2 common common JJ cord-347946-i6kx3n6m 573 3 pathway pathway NN cord-347946-i6kx3n6m 573 4 mediated mediate VBN cord-347946-i6kx3n6m 573 5 through through IN cord-347946-i6kx3n6m 573 6 Toll Toll NNP cord-347946-i6kx3n6m 573 7 - - HYPH cord-347946-i6kx3n6m 573 8 like like JJ cord-347946-i6kx3n6m 573 9 receptors receptor NNS cord-347946-i6kx3n6m 573 10 leads lead VBZ cord-347946-i6kx3n6m 573 11 to to IN cord-347946-i6kx3n6m 573 12 T T NNP cord-347946-i6kx3n6m 573 13 - - HYPH cord-347946-i6kx3n6m 573 14 and and CC cord-347946-i6kx3n6m 573 15 natural natural JJ cord-347946-i6kx3n6m 573 16 killer killer NN cord-347946-i6kx3n6m 573 17 - - HYPH cord-347946-i6kx3n6m 573 18 cell cell NN cord-347946-i6kx3n6m 573 19 immunosuppression immunosuppression NN cord-347946-i6kx3n6m 573 20 CRP crp NN cord-347946-i6kx3n6m 573 21 , , , cord-347946-i6kx3n6m 573 22 IL-6 IL-6 NNP cord-347946-i6kx3n6m 573 23 and and CC cord-347946-i6kx3n6m 573 24 depression depression NN cord-347946-i6kx3n6m 573 25 : : : cord-347946-i6kx3n6m 573 26 a a DT cord-347946-i6kx3n6m 573 27 systematic systematic JJ cord-347946-i6kx3n6m 573 28 review review NN cord-347946-i6kx3n6m 573 29 and and CC cord-347946-i6kx3n6m 573 30 meta meta NNP cord-347946-i6kx3n6m 573 31 - - HYPH cord-347946-i6kx3n6m 573 32 analysis analysis NN cord-347946-i6kx3n6m 573 33 of of IN cord-347946-i6kx3n6m 573 34 longitudinal longitudinal JJ cord-347946-i6kx3n6m 573 35 studies study NNS cord-347946-i6kx3n6m 573 36 Regulation Regulation NNP cord-347946-i6kx3n6m 573 37 of of IN cord-347946-i6kx3n6m 573 38 human human JJ cord-347946-i6kx3n6m 573 39 life life NN cord-347946-i6kx3n6m 573 40 histories history NNS cord-347946-i6kx3n6m 573 41 : : : cord-347946-i6kx3n6m 573 42 the the DT cord-347946-i6kx3n6m 573 43 role role NN cord-347946-i6kx3n6m 573 44 of of IN cord-347946-i6kx3n6m 573 45 the the DT cord-347946-i6kx3n6m 573 46 inflammatory inflammatory JJ cord-347946-i6kx3n6m 573 47 host host NN cord-347946-i6kx3n6m 573 48 response response NN cord-347946-i6kx3n6m 574 1 Decreased decrease VBN cord-347946-i6kx3n6m 574 2 plasma plasma NN cord-347946-i6kx3n6m 574 3 leptin leptin NN cord-347946-i6kx3n6m 574 4 concentrations concentration NNS cord-347946-i6kx3n6m 574 5 in in IN cord-347946-i6kx3n6m 574 6 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 574 7 patients patient NNS cord-347946-i6kx3n6m 574 8 are be VBP cord-347946-i6kx3n6m 574 9 associated associate VBN cord-347946-i6kx3n6m 574 10 with with IN cord-347946-i6kx3n6m 574 11 wasting wasting NN cord-347946-i6kx3n6m 574 12 and and CC cord-347946-i6kx3n6m 574 13 inflammation inflammation NN cord-347946-i6kx3n6m 574 14 Anti anti JJ cord-347946-i6kx3n6m 574 15 - - JJ cord-347946-i6kx3n6m 574 16 inflammatory inflammatory JJ cord-347946-i6kx3n6m 574 17 cytokine cytokine NN cord-347946-i6kx3n6m 574 18 profile profile NN cord-347946-i6kx3n6m 574 19 and and CC cord-347946-i6kx3n6m 574 20 mortality mortality NN cord-347946-i6kx3n6m 574 21 in in IN cord-347946-i6kx3n6m 574 22 febrile febrile JJ cord-347946-i6kx3n6m 574 23 patients patient NNS cord-347946-i6kx3n6m 574 24 Associations association NNS cord-347946-i6kx3n6m 574 25 of of IN cord-347946-i6kx3n6m 574 26 low low JJ cord-347946-i6kx3n6m 574 27 grade grade NN cord-347946-i6kx3n6m 574 28 inflammation inflammation NN cord-347946-i6kx3n6m 574 29 and and CC cord-347946-i6kx3n6m 574 30 endothelial endothelial JJ cord-347946-i6kx3n6m 574 31 dysfunction dysfunction NN cord-347946-i6kx3n6m 574 32 with with IN cord-347946-i6kx3n6m 574 33 depression- depression- NN cord-347946-i6kx3n6m 575 1 The the DT cord-347946-i6kx3n6m 575 2 Maastricht Maastricht NNP cord-347946-i6kx3n6m 575 3 Study Study NNP cord-347946-i6kx3n6m 575 4 Excavating Excavating NNP cord-347946-i6kx3n6m 575 5 Neandertal Neandertal NNP cord-347946-i6kx3n6m 575 6 and and CC cord-347946-i6kx3n6m 575 7 Denisovan Denisovan NNP cord-347946-i6kx3n6m 575 8 DNA DNA NNP cord-347946-i6kx3n6m 575 9 from from IN cord-347946-i6kx3n6m 575 10 the the DT cord-347946-i6kx3n6m 575 11 genomes genome NNS cord-347946-i6kx3n6m 575 12 of of IN cord-347946-i6kx3n6m 575 13 Melanesian melanesian JJ cord-347946-i6kx3n6m 575 14 individuals individual NNS cord-347946-i6kx3n6m 575 15 Stress Stress NNP cord-347946-i6kx3n6m 575 16 as as IN cord-347946-i6kx3n6m 575 17 an an DT cord-347946-i6kx3n6m 575 18 endogenous endogenous JJ cord-347946-i6kx3n6m 575 19 adjuvant adjuvant NN cord-347946-i6kx3n6m 575 20 : : : cord-347946-i6kx3n6m 575 21 augmentation augmentation NN cord-347946-i6kx3n6m 575 22 of of IN cord-347946-i6kx3n6m 575 23 the the DT cord-347946-i6kx3n6m 575 24 immunization immunization NN cord-347946-i6kx3n6m 575 25 phase phase NN cord-347946-i6kx3n6m 575 26 of of IN cord-347946-i6kx3n6m 575 27 cell cell NN cord-347946-i6kx3n6m 575 28 - - HYPH cord-347946-i6kx3n6m 575 29 mediated mediate VBN cord-347946-i6kx3n6m 575 30 immunity immunity NN cord-347946-i6kx3n6m 575 31 Anxiety Anxiety NNP cord-347946-i6kx3n6m 575 32 disorders disorder NNS cord-347946-i6kx3n6m 575 33 and and CC cord-347946-i6kx3n6m 575 34 inflammation inflammation NN cord-347946-i6kx3n6m 575 35 in in IN cord-347946-i6kx3n6m 575 36 a a DT cord-347946-i6kx3n6m 575 37 large large JJ cord-347946-i6kx3n6m 575 38 adult adult NN cord-347946-i6kx3n6m 575 39 cohort cohort NN cord-347946-i6kx3n6m 575 40 Genetic genetic JJ cord-347946-i6kx3n6m 575 41 influence influence NN cord-347946-i6kx3n6m 575 42 on on IN cord-347946-i6kx3n6m 575 43 cytokine cytokine NN cord-347946-i6kx3n6m 575 44 production production NN cord-347946-i6kx3n6m 575 45 and and CC cord-347946-i6kx3n6m 575 46 fatal fatal JJ cord-347946-i6kx3n6m 575 47 meningococcal meningococcal JJ cord-347946-i6kx3n6m 575 48 disease disease NN cord-347946-i6kx3n6m 576 1 Interferon interferon NN cord-347946-i6kx3n6m 576 2 - - HYPH cord-347946-i6kx3n6m 576 3 alpha alpha NN cord-347946-i6kx3n6m 576 4 - - HYPH cord-347946-i6kx3n6m 576 5 induced induce VBN cord-347946-i6kx3n6m 576 6 depressive depressive JJ cord-347946-i6kx3n6m 576 7 symptoms symptom NNS cord-347946-i6kx3n6m 576 8 are be VBP cord-347946-i6kx3n6m 576 9 related relate VBN cord-347946-i6kx3n6m 576 10 to to IN cord-347946-i6kx3n6m 576 11 changes change NNS cord-347946-i6kx3n6m 576 12 in in IN cord-347946-i6kx3n6m 576 13 the the DT cord-347946-i6kx3n6m 576 14 cytokine cytokine NN cord-347946-i6kx3n6m 576 15 network network NN cord-347946-i6kx3n6m 576 16 but but CC cord-347946-i6kx3n6m 576 17 not not RB cord-347946-i6kx3n6m 576 18 to to IN cord-347946-i6kx3n6m 576 19 cortisol cortisol NN cord-347946-i6kx3n6m 576 20 Baseline baseline JJ cord-347946-i6kx3n6m 576 21 immune immune JJ cord-347946-i6kx3n6m 576 22 activation activation NN cord-347946-i6kx3n6m 576 23 as as IN cord-347946-i6kx3n6m 576 24 a a DT cord-347946-i6kx3n6m 576 25 risk risk NN cord-347946-i6kx3n6m 576 26 factor factor NN cord-347946-i6kx3n6m 576 27 for for IN cord-347946-i6kx3n6m 576 28 the the DT cord-347946-i6kx3n6m 576 29 onset onset NN cord-347946-i6kx3n6m 576 30 of of IN cord-347946-i6kx3n6m 576 31 depression depression NN cord-347946-i6kx3n6m 576 32 during during IN cord-347946-i6kx3n6m 576 33 interferonalpha interferonalpha NNP cord-347946-i6kx3n6m 576 34 treatment treatment NN cord-347946-i6kx3n6m 577 1 Early early JJ cord-347946-i6kx3n6m 577 2 increase increase NN cord-347946-i6kx3n6m 577 3 in in IN cord-347946-i6kx3n6m 577 4 vegetative vegetative JJ cord-347946-i6kx3n6m 577 5 symptoms symptom NNS cord-347946-i6kx3n6m 577 6 predicts predict VBZ cord-347946-i6kx3n6m 577 7 IFN IFN NNP cord-347946-i6kx3n6m 577 8 - - HYPH cord-347946-i6kx3n6m 577 9 alpha alpha NN cord-347946-i6kx3n6m 577 10 - - HYPH cord-347946-i6kx3n6m 577 11 induced induce VBN cord-347946-i6kx3n6m 577 12 cognitive cognitive JJ cord-347946-i6kx3n6m 577 13 - - HYPH cord-347946-i6kx3n6m 577 14 depressive depressive JJ cord-347946-i6kx3n6m 577 15 changes change NNS cord-347946-i6kx3n6m 577 16 Early early JJ cord-347946-i6kx3n6m 577 17 increase increase NN cord-347946-i6kx3n6m 577 18 in in IN cord-347946-i6kx3n6m 577 19 vegetative vegetative JJ cord-347946-i6kx3n6m 577 20 symptoms symptom NNS cord-347946-i6kx3n6m 577 21 predicts predict VBZ cord-347946-i6kx3n6m 577 22 IFN IFN NNP cord-347946-i6kx3n6m 577 23 - - HYPH cord-347946-i6kx3n6m 577 24 alpha alpha NN cord-347946-i6kx3n6m 577 25 - - HYPH cord-347946-i6kx3n6m 577 26 induced induce VBN cord-347946-i6kx3n6m 577 27 cognitive cognitive JJ cord-347946-i6kx3n6m 577 28 - - HYPH cord-347946-i6kx3n6m 577 29 depressive depressive JJ cord-347946-i6kx3n6m 577 30 changes change NNS cord-347946-i6kx3n6m 578 1 The the DT cord-347946-i6kx3n6m 578 2 role role NN cord-347946-i6kx3n6m 578 3 of of IN cord-347946-i6kx3n6m 578 4 indoleamine indoleamine NN cord-347946-i6kx3n6m 578 5 2,3-dioxygenase 2,3-dioxygenase CD cord-347946-i6kx3n6m 578 6 ( ( -LRB- cord-347946-i6kx3n6m 578 7 IDO IDO NNP cord-347946-i6kx3n6m 578 8 ) ) -RRB- cord-347946-i6kx3n6m 578 9 in in IN cord-347946-i6kx3n6m 578 10 the the DT cord-347946-i6kx3n6m 578 11 pathophysiology pathophysiology NN cord-347946-i6kx3n6m 578 12 of of IN cord-347946-i6kx3n6m 578 13 interferon interferon NN cord-347946-i6kx3n6m 578 14 - - HYPH cord-347946-i6kx3n6m 578 15 alpha alpha NN cord-347946-i6kx3n6m 578 16 - - HYPH cord-347946-i6kx3n6m 578 17 induced induce VBN cord-347946-i6kx3n6m 578 18 depression depression NN cord-347946-i6kx3n6m 578 19 Pulmonary Pulmonary NNP cord-347946-i6kx3n6m 578 20 Mycobacterium Mycobacterium NNP cord-347946-i6kx3n6m 578 21 tuberculosis tuberculosis NN cord-347946-i6kx3n6m 578 22 infection infection NN cord-347946-i6kx3n6m 578 23 in in IN cord-347946-i6kx3n6m 578 24 leptin leptin NN cord-347946-i6kx3n6m 578 25 - - HYPH cord-347946-i6kx3n6m 578 26 deficient deficient JJ cord-347946-i6kx3n6m 578 27 ob ob NNP cord-347946-i6kx3n6m 578 28 / / SYM cord-347946-i6kx3n6m 578 29 ob ob NNP cord-347946-i6kx3n6m 578 30 mice mouse NNS cord-347946-i6kx3n6m 578 31 Mood Mood NNP cord-347946-i6kx3n6m 578 32 disorders disorder NNS cord-347946-i6kx3n6m 578 33 and and CC cord-347946-i6kx3n6m 578 34 fertility fertility NN cord-347946-i6kx3n6m 578 35 in in IN cord-347946-i6kx3n6m 578 36 women woman NNS cord-347946-i6kx3n6m 578 37 : : : cord-347946-i6kx3n6m 578 38 a a DT cord-347946-i6kx3n6m 578 39 critical critical JJ cord-347946-i6kx3n6m 578 40 review review NN cord-347946-i6kx3n6m 578 41 of of IN cord-347946-i6kx3n6m 578 42 the the DT cord-347946-i6kx3n6m 578 43 literature literature NN cord-347946-i6kx3n6m 578 44 and and CC cord-347946-i6kx3n6m 578 45 implications implication NNS cord-347946-i6kx3n6m 578 46 for for IN cord-347946-i6kx3n6m 578 47 future future JJ cord-347946-i6kx3n6m 578 48 research research NN cord-347946-i6kx3n6m 578 49 Acute acute JJ cord-347946-i6kx3n6m 578 50 inflammation inflammation NN cord-347946-i6kx3n6m 578 51 and and CC cord-347946-i6kx3n6m 578 52 negative negative JJ cord-347946-i6kx3n6m 578 53 mood mood NN cord-347946-i6kx3n6m 578 54 : : : cord-347946-i6kx3n6m 578 55 mediation mediation NN cord-347946-i6kx3n6m 578 56 by by IN cord-347946-i6kx3n6m 578 57 cytokine cytokine NN cord-347946-i6kx3n6m 578 58 activation activation NN cord-347946-i6kx3n6m 578 59 Levels level NNS cord-347946-i6kx3n6m 578 60 of of IN cord-347946-i6kx3n6m 578 61 serum serum NN cord-347946-i6kx3n6m 578 62 interleukin interleukin NN cord-347946-i6kx3n6m 578 63 ( ( -LRB- cord-347946-i6kx3n6m 579 1 IL)-6 IL)-6 NNP cord-347946-i6kx3n6m 579 2 , , , cord-347946-i6kx3n6m 579 3 IL-1beta il-1beta NN cord-347946-i6kx3n6m 579 4 , , , cord-347946-i6kx3n6m 579 5 tumour tumour NN cord-347946-i6kx3n6m 579 6 necrosis necrosis NN cord-347946-i6kx3n6m 579 7 factor factor NN cord-347946-i6kx3n6m 579 8 - - HYPH cord-347946-i6kx3n6m 579 9 alpha alpha NN cord-347946-i6kx3n6m 579 10 and and CC cord-347946-i6kx3n6m 579 11 leptin leptin NN cord-347946-i6kx3n6m 579 12 and and CC cord-347946-i6kx3n6m 579 13 their -PRON- PRP$ cord-347946-i6kx3n6m 579 14 correlation correlation NN cord-347946-i6kx3n6m 579 15 in in IN cord-347946-i6kx3n6m 579 16 depression depression NN cord-347946-i6kx3n6m 579 17 Associations association NNS cord-347946-i6kx3n6m 579 18 among among IN cord-347946-i6kx3n6m 579 19 eczema eczema NN cord-347946-i6kx3n6m 579 20 , , , cord-347946-i6kx3n6m 579 21 asthma asthma NN cord-347946-i6kx3n6m 579 22 , , , cord-347946-i6kx3n6m 579 23 serum serum NN cord-347946-i6kx3n6m 579 24 immunoglobulin immunoglobulin NN cord-347946-i6kx3n6m 579 25 E e NN cord-347946-i6kx3n6m 579 26 and and CC cord-347946-i6kx3n6m 579 27 depression depression NN cord-347946-i6kx3n6m 579 28 in in IN cord-347946-i6kx3n6m 579 29 adults adult NNS cord-347946-i6kx3n6m 579 30 : : : cord-347946-i6kx3n6m 580 1 a a DT cord-347946-i6kx3n6m 580 2 populationbased populationbased JJ cord-347946-i6kx3n6m 580 3 study study NN cord-347946-i6kx3n6m 580 4 Leptin Leptin NNP cord-347946-i6kx3n6m 580 5 , , , cord-347946-i6kx3n6m 580 6 adiponectin adiponectin NN cord-347946-i6kx3n6m 580 7 , , , cord-347946-i6kx3n6m 580 8 leptin leptin NN cord-347946-i6kx3n6m 580 9 to to IN cord-347946-i6kx3n6m 580 10 adiponectin adiponectin NN cord-347946-i6kx3n6m 580 11 ratio ratio NN cord-347946-i6kx3n6m 580 12 and and CC cord-347946-i6kx3n6m 580 13 insulin insulin NN cord-347946-i6kx3n6m 580 14 resistance resistance NN cord-347946-i6kx3n6m 580 15 in in IN cord-347946-i6kx3n6m 580 16 depressive depressive JJ cord-347946-i6kx3n6m 580 17 women woman NNS cord-347946-i6kx3n6m 580 18 SIRT1 SIRT1 NNP cord-347946-i6kx3n6m 580 19 suppresses suppress VBZ cord-347946-i6kx3n6m 580 20 activator activator NN cord-347946-i6kx3n6m 580 21 protein-1 protein-1 NNP cord-347946-i6kx3n6m 580 22 transcriptional transcriptional JJ cord-347946-i6kx3n6m 580 23 activity activity NN cord-347946-i6kx3n6m 580 24 and and CC cord-347946-i6kx3n6m 580 25 cyclooxygenase-2 cyclooxygenase-2 NNP cord-347946-i6kx3n6m 580 26 expression expression NN cord-347946-i6kx3n6m 580 27 in in IN cord-347946-i6kx3n6m 580 28 macrophages macrophage NNS cord-347946-i6kx3n6m 580 29 Hypothalamic Hypothalamic NNP cord-347946-i6kx3n6m 580 30 IKKbeta/ ikkbeta/ NN cord-347946-i6kx3n6m 580 31 NF NF NNP cord-347946-i6kx3n6m 580 32 - - HYPH cord-347946-i6kx3n6m 580 33 kappaB kappaB NNP cord-347946-i6kx3n6m 580 34 and and CC cord-347946-i6kx3n6m 580 35 ER ER NNP cord-347946-i6kx3n6m 581 1 stress stress NN cord-347946-i6kx3n6m 581 2 link link NN cord-347946-i6kx3n6m 581 3 overnutrition overnutrition NN cord-347946-i6kx3n6m 581 4 to to IN cord-347946-i6kx3n6m 581 5 energy energy NN cord-347946-i6kx3n6m 581 6 imbalance imbalance NN cord-347946-i6kx3n6m 581 7 and and CC cord-347946-i6kx3n6m 581 8 obesity obesity NN cord-347946-i6kx3n6m 581 9 Roles role NNS cord-347946-i6kx3n6m 581 10 of of IN cord-347946-i6kx3n6m 581 11 SIRT1 SIRT1 NNS cord-347946-i6kx3n6m 581 12 in in IN cord-347946-i6kx3n6m 581 13 the the DT cord-347946-i6kx3n6m 581 14 acute acute JJ cord-347946-i6kx3n6m 581 15 and and CC cord-347946-i6kx3n6m 581 16 restorative restorative JJ cord-347946-i6kx3n6m 581 17 phases phase NNS cord-347946-i6kx3n6m 581 18 following follow VBG cord-347946-i6kx3n6m 581 19 induction induction NN cord-347946-i6kx3n6m 581 20 of of IN cord-347946-i6kx3n6m 581 21 inflammation inflammation NN cord-347946-i6kx3n6m 582 1 Psychological psychological JJ cord-347946-i6kx3n6m 582 2 stress stress NN cord-347946-i6kx3n6m 582 3 induces induce VBZ cord-347946-i6kx3n6m 582 4 hypoferremia hypoferremia NN cord-347946-i6kx3n6m 582 5 through through IN cord-347946-i6kx3n6m 582 6 the the DT cord-347946-i6kx3n6m 582 7 IL-6-hepcidin IL-6-hepcidin : cord-347946-i6kx3n6m 582 8 axis axis NN cord-347946-i6kx3n6m 582 9 in in IN cord-347946-i6kx3n6m 582 10 rats rat NNS cord-347946-i6kx3n6m 582 11 Relation relation NN cord-347946-i6kx3n6m 582 12 of of IN cord-347946-i6kx3n6m 582 13 stressors stressor NNS cord-347946-i6kx3n6m 582 14 and and CC cord-347946-i6kx3n6m 582 15 depressive depressive JJ cord-347946-i6kx3n6m 582 16 symptoms symptom NNS cord-347946-i6kx3n6m 582 17 to to IN cord-347946-i6kx3n6m 582 18 clinical clinical JJ cord-347946-i6kx3n6m 582 19 progression progression NN cord-347946-i6kx3n6m 582 20 of of IN cord-347946-i6kx3n6m 582 21 viral viral JJ cord-347946-i6kx3n6m 582 22 illness illness NN