id author title date pages extension mime words sentences flesch summary cache txt cord-355165-xc6ythgp van den Wijngaard, Cees Validation of Syndromic Surveillance for Respiratory Pathogen Activity 2008-06-17 .txt text/plain 4561 224 42 We defi ned syndrome data as data in health-related registries that refl ect infectious disease activity without identifying causative pathogen(s) or focusing on pathogenspecifi c symptoms (such as routine surveillance data for infl uenza-like illness [11] or surveillance of acute fl accid paralysis for polio [12] ). Six registries were selected ( Table 1 ) that collected data on work absenteeism, general practice (GP) consultations, prescription medications dispensed by pharmacies, diagnostic test requests (laboratory submissions) (13), hospital diagnoses, and deaths. As a reference for the syndrome data, we included specifi c pathogen counts for 1999-2004 from the following sources: 1) Weekly Sentinel Surveillance System of the Dutch Working Group on Clinical Virology (which covers 38%-73% of the population of the Netherlands [14] respiratory disease-related counts of Streptococcus pneumoniae (data in 2003-2004 were interpolated for 2 laboratories during short periods of missing data; total coverage 24%); and 3) national mandatory notifi cations of pertussis. ./cache/cord-355165-xc6ythgp.txt ./txt/cord-355165-xc6ythgp.txt