id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297440-uw263cfc	Peacock, Sharon J	Microbial sequencing to improve individual and population health	2014-11-19		.txt	text/plain	1281	63	37	Personalized anti-infective therapies and surveillance of emergent pathogen outbreaks are just two examples of the potential benefits of merging the fields of genomics and infectious diseases. Sequencing will bring improvements in the detection and control of outbreaks associated with multidrugresistant and other pathogens in hospitals and the community [1] . Passive surveillance using sequence data generated for clinical use would provide an overview of the emergence and spread of antimicrobial resistance. Active genomic surveillance of key human pathogens would provide an early warning system for outbreaks, inform vaccine strategies through tracking of vaccine escape, and detect the emergence of new clones that harbor known or novel virulence determinants. New methods to handle and process everexpanding pathogen-specific microbial genome databases will also be needed, including global and region-specific listings of gene mutations associated with drug resistance. Further technological advances are also required to reduce the turnaround time between taking a clinical sample and generating sequence data.	./cache/cord-297440-uw263cfc.txt	./txt/cord-297440-uw263cfc.txt