id sid tid token lemma pos cord-332255-7sxioviw 1 1 key key JJ cord-332255-7sxioviw 1 2 : : : cord-332255-7sxioviw 1 3 cord-332255 cord-332255 NNP cord-332255-7sxioviw 1 4 - - HYPH cord-332255-7sxioviw 1 5 7sxioviw 7sxioviw NNP cord-332255-7sxioviw 2 1 authors author NNS cord-332255-7sxioviw 2 2 : : : cord-332255-7sxioviw 2 3 Narita Narita NNP cord-332255-7sxioviw 2 4 , , , cord-332255-7sxioviw 2 5 M. M. NNP cord-332255-7sxioviw 2 6 ; ; : cord-332255-7sxioviw 2 7 Fukusho Fukusho NNP cord-332255-7sxioviw 2 8 , , , cord-332255-7sxioviw 2 9 A. a. NN cord-332255-7sxioviw 2 10 ; ; : cord-332255-7sxioviw 2 11 Shimizu Shimizu NNP cord-332255-7sxioviw 2 12 , , , cord-332255-7sxioviw 2 13 Y. Y. NNP cord-332255-7sxioviw 2 14 title title NN cord-332255-7sxioviw 2 15 : : : cord-332255-7sxioviw 3 1 Electron electron NN cord-332255-7sxioviw 3 2 microscopy microscopy NN cord-332255-7sxioviw 3 3 of of IN cord-332255-7sxioviw 3 4 the the DT cord-332255-7sxioviw 3 5 intestine intestine NN cord-332255-7sxioviw 3 6 of of IN cord-332255-7sxioviw 3 7 gnotobiotic gnotobiotic JJ cord-332255-7sxioviw 3 8 piglets piglet NNS cord-332255-7sxioviw 3 9 infected infect VBN cord-332255-7sxioviw 3 10 with with IN cord-332255-7sxioviw 3 11 porcine porcine JJ cord-332255-7sxioviw 3 12 rotavirus rotavirus NN cord-332255-7sxioviw 3 13 date date NN cord-332255-7sxioviw 3 14 : : : cord-332255-7sxioviw 3 15 1982 1982 CD cord-332255-7sxioviw 3 16 - - SYM cord-332255-7sxioviw 3 17 10 10 CD cord-332255-7sxioviw 3 18 - - SYM cord-332255-7sxioviw 3 19 31 31 CD cord-332255-7sxioviw 3 20 journal journal NN cord-332255-7sxioviw 3 21 : : : cord-332255-7sxioviw 3 22 Journal Journal NNP cord-332255-7sxioviw 3 23 of of IN cord-332255-7sxioviw 3 24 Comparative Comparative NNP cord-332255-7sxioviw 3 25 Pathology Pathology NNP cord-332255-7sxioviw 3 26 DOI doi NN cord-332255-7sxioviw 3 27 : : : cord-332255-7sxioviw 3 28 10.1016/0021 10.1016/0021 CD cord-332255-7sxioviw 3 29 - - HYPH cord-332255-7sxioviw 3 30 9975(82)90011 9975(82)90011 CD cord-332255-7sxioviw 3 31 - - HYPH cord-332255-7sxioviw 3 32 1 1 CD cord-332255-7sxioviw 3 33 sha sha NN cord-332255-7sxioviw 3 34 : : : cord-332255-7sxioviw 3 35 d566761a00777e1dc241fd4966359faf254369c3 d566761a00777e1dc241fd4966359faf254369c3 NNP cord-332255-7sxioviw 3 36 doc_id doc_id NNPS cord-332255-7sxioviw 3 37 : : : cord-332255-7sxioviw 3 38 332255 332255 CD cord-332255-7sxioviw 3 39 cord_uid cord_uid NNS cord-332255-7sxioviw 3 40 : : : cord-332255-7sxioviw 4 1 7sxioviw 7sxioviw LS cord-332255-7sxioviw 4 2 Abstract Abstract NNP cord-332255-7sxioviw 4 3 Five five CD cord-332255-7sxioviw 4 4 gnotobiotic gnotobiotic JJ cord-332255-7sxioviw 4 5 piglets piglet NNS cord-332255-7sxioviw 4 6 inoculated inoculate VBD cord-332255-7sxioviw 4 7 orally orally RB cord-332255-7sxioviw 4 8 with with IN cord-332255-7sxioviw 4 9 porcine porcine JJ cord-332255-7sxioviw 4 10 rotavirus rotavirus NN cord-332255-7sxioviw 4 11 developed develop VBD cord-332255-7sxioviw 4 12 an an DT cord-332255-7sxioviw 4 13 enteric enteric JJ cord-332255-7sxioviw 4 14 lesion lesion NN cord-332255-7sxioviw 4 15 . . . cord-332255-7sxioviw 5 1 Electron electron NN cord-332255-7sxioviw 5 2 microscopy microscopy NN cord-332255-7sxioviw 5 3 of of IN cord-332255-7sxioviw 5 4 the the DT cord-332255-7sxioviw 5 5 mucosal mucosal JJ cord-332255-7sxioviw 5 6 epithelium epithelium NN cord-332255-7sxioviw 5 7 12 12 CD cord-332255-7sxioviw 5 8 h h NN cord-332255-7sxioviw 5 9 after after IN cord-332255-7sxioviw 5 10 inoculation inoculation NN cord-332255-7sxioviw 5 11 showed show VBD cord-332255-7sxioviw 5 12 that that IN cord-332255-7sxioviw 5 13 the the DT cord-332255-7sxioviw 5 14 virus virus NN cord-332255-7sxioviw 5 15 penetrates penetrate VBZ cord-332255-7sxioviw 5 16 into into IN cord-332255-7sxioviw 5 17 the the DT cord-332255-7sxioviw 5 18 absorptive absorptive JJ cord-332255-7sxioviw 5 19 cells cell NNS cord-332255-7sxioviw 5 20 between between IN cord-332255-7sxioviw 5 21 microvilli microvilli NN cord-332255-7sxioviw 5 22 , , , cord-332255-7sxioviw 5 23 possibly possibly RB cord-332255-7sxioviw 5 24 by by IN cord-332255-7sxioviw 5 25 a a DT cord-332255-7sxioviw 5 26 pinocytic pinocytic JJ cord-332255-7sxioviw 5 27 mechanism mechanism NN cord-332255-7sxioviw 5 28 . . . cord-332255-7sxioviw 6 1 Afterwards afterwards RB cord-332255-7sxioviw 6 2 , , , cord-332255-7sxioviw 6 3 virus virus NN cord-332255-7sxioviw 6 4 particles particle NNS cord-332255-7sxioviw 6 5 were be VBD cord-332255-7sxioviw 6 6 most most RBS cord-332255-7sxioviw 6 7 often often RB cord-332255-7sxioviw 6 8 seen see VBN cord-332255-7sxioviw 6 9 within within IN cord-332255-7sxioviw 6 10 dilated dilated JJ cord-332255-7sxioviw 6 11 cisternae cisternae NN cord-332255-7sxioviw 6 12 of of IN cord-332255-7sxioviw 6 13 the the DT cord-332255-7sxioviw 6 14 rough rough JJ cord-332255-7sxioviw 6 15 endoplasmic endoplasmic NN cord-332255-7sxioviw 6 16 reticulum reticulum NN cord-332255-7sxioviw 6 17 ( ( -LRB- cord-332255-7sxioviw 6 18 RER RER NNP cord-332255-7sxioviw 6 19 ) ) -RRB- cord-332255-7sxioviw 6 20 . . . cord-332255-7sxioviw 7 1 These these DT cord-332255-7sxioviw 7 2 infected infected JJ cord-332255-7sxioviw 7 3 cells cell NNS cord-332255-7sxioviw 7 4 showed show VBD cord-332255-7sxioviw 7 5 a a DT cord-332255-7sxioviw 7 6 range range NN cord-332255-7sxioviw 7 7 of of IN cord-332255-7sxioviw 7 8 changes change NNS cord-332255-7sxioviw 7 9 , , , cord-332255-7sxioviw 7 10 such such JJ cord-332255-7sxioviw 7 11 as as IN cord-332255-7sxioviw 7 12 disruption disruption NN cord-332255-7sxioviw 7 13 of of IN cord-332255-7sxioviw 7 14 the the DT cord-332255-7sxioviw 7 15 microvilli microvilli NN cord-332255-7sxioviw 7 16 , , , cord-332255-7sxioviw 7 17 loss loss NN cord-332255-7sxioviw 7 18 of of IN cord-332255-7sxioviw 7 19 cytoplasmic cytoplasmic JJ cord-332255-7sxioviw 7 20 density density NN cord-332255-7sxioviw 7 21 and and CC cord-332255-7sxioviw 7 22 deposition deposition NN cord-332255-7sxioviw 7 23 of of IN cord-332255-7sxioviw 7 24 lipid lipid NN cord-332255-7sxioviw 7 25 droplets droplet NNS cord-332255-7sxioviw 7 26 . . . cord-332255-7sxioviw 8 1 Subsequently subsequently RB cord-332255-7sxioviw 8 2 , , , cord-332255-7sxioviw 8 3 most most JJS cord-332255-7sxioviw 8 4 of of IN cord-332255-7sxioviw 8 5 the the DT cord-332255-7sxioviw 8 6 epithelial epithelial JJ cord-332255-7sxioviw 8 7 cells cell NNS cord-332255-7sxioviw 8 8 were be VBD cord-332255-7sxioviw 8 9 desquamated desquamate VBN cord-332255-7sxioviw 8 10 from from IN cord-332255-7sxioviw 8 11 the the DT cord-332255-7sxioviw 8 12 villi villi NN cord-332255-7sxioviw 8 13 . . . cord-332255-7sxioviw 9 1 The the DT cord-332255-7sxioviw 9 2 interaction interaction NN cord-332255-7sxioviw 9 3 of of IN cord-332255-7sxioviw 9 4 virus virus NN cord-332255-7sxioviw 9 5 and and CC cord-332255-7sxioviw 9 6 intestinal intestinal JJ cord-332255-7sxioviw 9 7 cells cell NNS cord-332255-7sxioviw 9 8 thus thus RB cord-332255-7sxioviw 9 9 indicates indicate VBZ cord-332255-7sxioviw 9 10 that that IN cord-332255-7sxioviw 9 11 rotavirus rotavirus NN cord-332255-7sxioviw 9 12 is be VBZ cord-332255-7sxioviw 9 13 pathogenic pathogenic JJ cord-332255-7sxioviw 9 14 for for IN cord-332255-7sxioviw 9 15 the the DT cord-332255-7sxioviw 9 16 epithelial epithelial JJ cord-332255-7sxioviw 9 17 cells cell NNS cord-332255-7sxioviw 9 18 . . . cord-332255-7sxioviw 10 1 Porcine porcine JJ cord-332255-7sxioviw 10 2 rotavirus rotavirus NN cord-332255-7sxioviw 10 3 is be VBZ cord-332255-7sxioviw 10 4 an an DT cord-332255-7sxioviw 10 5 enteropathogen enteropathogen NN cord-332255-7sxioviw 10 6 for for IN cord-332255-7sxioviw 10 7 neonatal neonatal JJ cord-332255-7sxioviw 10 8 piglets piglet NNS cord-332255-7sxioviw 11 1 ( ( -LRB- cord-332255-7sxioviw 11 2 Fukusho Fukusho NNP cord-332255-7sxioviw 11 3 , , , cord-332255-7sxioviw 11 4 Shimizu Shimizu NNP cord-332255-7sxioviw 11 5 and and CC cord-332255-7sxioviw 11 6 Ito Ito NNP cord-332255-7sxioviw 11 7 , , , cord-332255-7sxioviw 11 8 1981 1981 CD cord-332255-7sxioviw 11 9 ; ; : cord-332255-7sxioviw 11 10 Lecce Lecce NNP cord-332255-7sxioviw 11 11 and and CC cord-332255-7sxioviw 11 12 King King NNP cord-332255-7sxioviw 11 13 , , , cord-332255-7sxioviw 11 14 1978 1978 CD cord-332255-7sxioviw 11 15 ; ; : cord-332255-7sxioviw 11 16 McNulty McNulty NNP cord-332255-7sxioviw 11 17 , , , cord-332255-7sxioviw 11 18 Pearson Pearson NNP cord-332255-7sxioviw 11 19 , , , cord-332255-7sxioviw 11 20 McFerran McFerran NNP cord-332255-7sxioviw 11 21 , , , cord-332255-7sxioviw 11 22 Collins Collins NNP cord-332255-7sxioviw 11 23 and and CC cord-332255-7sxioviw 11 24 Allan Allan NNP cord-332255-7sxioviw 11 25 , , , cord-332255-7sxioviw 11 26 1976 1976 CD cord-332255-7sxioviw 11 27 ) ) -RRB- cord-332255-7sxioviw 11 28 . . . cord-332255-7sxioviw 12 1 Mortality mortality NN cord-332255-7sxioviw 12 2 is be VBZ cord-332255-7sxioviw 12 3 high high JJ cord-332255-7sxioviw 12 4 in in IN cord-332255-7sxioviw 12 5 pigs pig NNS cord-332255-7sxioviw 12 6 infected infect VBN cord-332255-7sxioviw 12 7 during during IN cord-332255-7sxioviw 12 8 the the DT cord-332255-7sxioviw 12 9 first first JJ cord-332255-7sxioviw 12 10 3 3 CD cord-332255-7sxioviw 12 11 days day NNS cord-332255-7sxioviw 12 12 after after IN cord-332255-7sxioviw 12 13 birth birth NN cord-332255-7sxioviw 12 14 , , , cord-332255-7sxioviw 12 15 but but CC cord-332255-7sxioviw 12 16 it -PRON- PRP cord-332255-7sxioviw 12 17 is be VBZ cord-332255-7sxioviw 12 18 reduced reduce VBN cord-332255-7sxioviw 12 19 as as IN cord-332255-7sxioviw 12 20 the the DT cord-332255-7sxioviw 12 21 pig pig NN cord-332255-7sxioviw 12 22 increases increase VBZ cord-332255-7sxioviw 12 23 in in IN cord-332255-7sxioviw 12 24 age age NN cord-332255-7sxioviw 12 25 ( ( -LRB- cord-332255-7sxioviw 12 26 Pearson Pearson NNP cord-332255-7sxioviw 12 27 and and CC cord-332255-7sxioviw 12 28 McNulty McNulty NNP cord-332255-7sxioviw 12 29 , , , cord-332255-7sxioviw 12 30 1977 1977 CD cord-332255-7sxioviw 12 31 ) ) -RRB- cord-332255-7sxioviw 12 32 . . . cord-332255-7sxioviw 13 1 The the DT cord-332255-7sxioviw 13 2 pathogenesis pathogenesis NN cord-332255-7sxioviw 13 3 of of IN cord-332255-7sxioviw 13 4 porcine porcine JJ cord-332255-7sxioviw 13 5 rotavirus rotavirus NN cord-332255-7sxioviw 13 6 in in IN cord-332255-7sxioviw 13 7 gnotobiotic gnotobiotic JJ cord-332255-7sxioviw 13 8 piglets piglet NNS cord-332255-7sxioviw 13 9 was be VBD cord-332255-7sxioviw 13 10 studied study VBN cord-332255-7sxioviw 13 11 by by IN cord-332255-7sxioviw 13 12 light light JJ cord-332255-7sxioviw 13 13 microscopy microscopy NNS cord-332255-7sxioviw 13 14 ( ( -LRB- cord-332255-7sxioviw 13 15 LM LM NNP cord-332255-7sxioviw 13 16 ) ) -RRB- cord-332255-7sxioviw 13 17 , , , cord-332255-7sxioviw 13 18 fl fl NNP cord-332255-7sxioviw 13 19 uorescent uorescent NNP cord-332255-7sxioviw 13 20 antibody antibody NN cord-332255-7sxioviw 13 21 technique technique NN cord-332255-7sxioviw 13 22 ( ( -LRB- cord-332255-7sxioviw 13 23 FA FA NNP cord-332255-7sxioviw 13 24 ) ) -RRB- cord-332255-7sxioviw 13 25 , , , cord-332255-7sxioviw 13 26 scanning scan VBG cord-332255-7sxioviw 13 27 electron electron NN cord-332255-7sxioviw 13 28 microscopy microscopy NN cord-332255-7sxioviw 13 29 ( ( -LRB- cord-332255-7sxioviw 13 30 SEM SEM NNP cord-332255-7sxioviw 13 31 ) ) -RRB- cord-332255-7sxioviw 13 32 and and CC cord-332255-7sxioviw 13 33 transmission transmission NN cord-332255-7sxioviw 13 34 electron electron NN cord-332255-7sxioviw 13 35 microscopy microscopy NN cord-332255-7sxioviw 13 36 ( ( -LRB- cord-332255-7sxioviw 13 37 TEM TEM NNP cord-332255-7sxioviw 13 38 ) ) -RRB- cord-332255-7sxioviw 13 39 , , , cord-332255-7sxioviw 13 40 and and CC cord-332255-7sxioviw 13 41 it -PRON- PRP cord-332255-7sxioviw 13 42 was be VBD cord-332255-7sxioviw 13 43 demonstrated demonstrate VBN cord-332255-7sxioviw 13 44 that that IN cord-332255-7sxioviw 13 45 clinical clinical JJ cord-332255-7sxioviw 13 46 signs sign NNS cord-332255-7sxioviw 13 47 were be VBD cord-332255-7sxioviw 13 48 correlated correlate VBN cord-332255-7sxioviw 13 49 with with IN cord-332255-7sxioviw 13 50 viral viral JJ cord-332255-7sxioviw 13 51 replication replication NN cord-332255-7sxioviw 13 52 and and CC cord-332255-7sxioviw 13 53 with with IN cord-332255-7sxioviw 13 54 induced induce VBN cord-332255-7sxioviw 13 55 virus virus NN cord-332255-7sxioviw 13 56 lesions lesion NNS cord-332255-7sxioviw 13 57 in in IN cord-332255-7sxioviw 13 58 the the DT cord-332255-7sxioviw 13 59 small small JJ cord-332255-7sxioviw 13 60 intestine intestine NN cord-332255-7sxioviw 13 61 ( ( -LRB- cord-332255-7sxioviw 13 62 McAdaragh McAdaragh NNP cord-332255-7sxioviw 13 63 , , , cord-332255-7sxioviw 13 64 Bergeland Bergeland NNP cord-332255-7sxioviw 13 65 , , , cord-332255-7sxioviw 13 66 Meyer Meyer NNP cord-332255-7sxioviw 13 67 , , , cord-332255-7sxioviw 13 68 Johnshoy Johnshoy NNP cord-332255-7sxioviw 13 69 , , , cord-332255-7sxioviw 13 70 Stotz Stotz NNP cord-332255-7sxioviw 13 71 , , , cord-332255-7sxioviw 13 72 Benfield Benfield NNP cord-332255-7sxioviw 13 73 and and CC cord-332255-7sxioviw 13 74 Hammer Hammer NNP cord-332255-7sxioviw 13 75 , , , cord-332255-7sxioviw 13 76 1980 1980 CD cord-332255-7sxioviw 13 77 ; ; : cord-332255-7sxioviw 13 78 Narita Narita NNP cord-332255-7sxioviw 13 79 , , , cord-332255-7sxioviw 13 80 Fukusho Fukusho NNP cord-332255-7sxioviw 13 81 , , , cord-332255-7sxioviw 13 82 Konno Konno NNP cord-332255-7sxioviw 13 83 and and CC cord-332255-7sxioviw 13 84 Shimizu Shimizu NNP cord-332255-7sxioviw 13 85 , , , cord-332255-7sxioviw 13 86 1982 1982 CD cord-332255-7sxioviw 13 87 ; ; : cord-332255-7sxioviw 13 88 Pearson Pearson NNP cord-332255-7sxioviw 13 89 and and CC cord-332255-7sxioviw 13 90 McNulty McNulty NNP cord-332255-7sxioviw 13 91 , , , cord-332255-7sxioviw 13 92 1979 1979 CD cord-332255-7sxioviw 13 93 ; ; : cord-332255-7sxioviw 13 94 Theil Theil NNP cord-332255-7sxioviw 13 95 , , , cord-332255-7sxioviw 13 96 Bohl Bohl NNP cord-332255-7sxioviw 13 97 , , , cord-332255-7sxioviw 13 98 Cross Cross NNP cord-332255-7sxioviw 13 99 , , , cord-332255-7sxioviw 13 100 Kohler Kohler NNP cord-332255-7sxioviw 13 101 and and CC cord-332255-7sxioviw 13 102 Agnes Agnes NNP cord-332255-7sxioviw 13 103 , , , cord-332255-7sxioviw 13 104 1978 1978 CD cord-332255-7sxioviw 13 105 ; ; : cord-332255-7sxioviw 13 106 Torres Torres NNP cord-332255-7sxioviw 13 107 - - HYPH cord-332255-7sxioviw 13 108 Medina Medina NNP cord-332255-7sxioviw 13 109 and and CC cord-332255-7sxioviw 13 110 Underdahl Underdahl NNP cord-332255-7sxioviw 13 111 , , , cord-332255-7sxioviw 13 112 1980 1980 CD cord-332255-7sxioviw 13 113 ) ) -RRB- cord-332255-7sxioviw 13 114 . . . cord-332255-7sxioviw 14 1 However however RB cord-332255-7sxioviw 14 2 , , , cord-332255-7sxioviw 14 3 there there EX cord-332255-7sxioviw 14 4 are be VBP cord-332255-7sxioviw 14 5 as as RB cord-332255-7sxioviw 14 6 yet yet RB cord-332255-7sxioviw 14 7 no no DT cord-332255-7sxioviw 14 8 reports report NNS cord-332255-7sxioviw 14 9 about about IN cord-332255-7sxioviw 14 10 the the DT cord-332255-7sxioviw 14 11 penetration penetration NN cord-332255-7sxioviw 14 12 of of IN cord-332255-7sxioviw 14 13 rotaviruses rotavirus NNS cord-332255-7sxioviw 14 14 into into IN cord-332255-7sxioviw 14 15 the the DT cord-332255-7sxioviw 14 16 epithelial epithelial JJ cord-332255-7sxioviw 14 17 cells cell NNS cord-332255-7sxioviw 14 18 . . . cord-332255-7sxioviw 15 1 The the DT cord-332255-7sxioviw 15 2 present present JJ cord-332255-7sxioviw 15 3 paper paper NN cord-332255-7sxioviw 15 4 describes describe VBZ cord-332255-7sxioviw 15 5 the the DT cord-332255-7sxioviw 15 6 morphological morphological JJ cord-332255-7sxioviw 15 7 changes change NNS cord-332255-7sxioviw 15 8 in in IN cord-332255-7sxioviw 15 9 infected infected JJ cord-332255-7sxioviw 15 10 intestinal intestinal JJ cord-332255-7sxioviw 15 11 cells cell NNS cord-332255-7sxioviw 15 12 of of IN cord-332255-7sxioviw 15 13 2-day 2-day JJ cord-332255-7sxioviw 15 14 - - HYPH cord-332255-7sxioviw 15 15 old old JJ cord-332255-7sxioviw 15 16 piglets piglet NNS cord-332255-7sxioviw 15 17 inoculated inoculate VBD cord-332255-7sxioviw 15 18 orally orally RB cord-332255-7sxioviw 15 19 with with IN cord-332255-7sxioviw 15 20 porcine porcine JJ cord-332255-7sxioviw 15 21 rotavirus rotavirus NN cord-332255-7sxioviw 15 22 and and CC cord-332255-7sxioviw 15 23 discusses discuss VBZ cord-332255-7sxioviw 15 24 the the DT cord-332255-7sxioviw 15 25 penetration penetration NN cord-332255-7sxioviw 15 26 of of IN cord-332255-7sxioviw 15 27 virus virus NN cord-332255-7sxioviw 15 28 into into IN cord-332255-7sxioviw 15 29 the the DT cord-332255-7sxioviw 15 30 absorptive absorptive JJ cord-332255-7sxioviw 15 31 cells cell NNS cord-332255-7sxioviw 15 32 . . . cord-332255-7sxioviw 16 1 This this DT cord-332255-7sxioviw 16 2 was be VBD cord-332255-7sxioviw 16 3 prepared prepare VBN cord-332255-7sxioviw 16 4 as as IN cord-332255-7sxioviw 16 5 previously previously RB cord-332255-7sxioviw 16 6 described describe VBN cord-332255-7sxioviw 16 7 ( ( -LRB- cord-332255-7sxioviw 16 8 Narita Narita NNP cord-332255-7sxioviw 16 9 et et NNP cord-332255-7sxioviw 16 10 al al NNP cord-332255-7sxioviw 16 11 . . NNP cord-332255-7sxioviw 16 12 , , , cord-332255-7sxioviw 16 13 1982 1982 CD cord-332255-7sxioviw 16 14 ) ) -RRB- cord-332255-7sxioviw 16 15 . . . cord-332255-7sxioviw 17 1 Briefly briefly RB cord-332255-7sxioviw 17 2 , , , cord-332255-7sxioviw 17 3 a a DT cord-332255-7sxioviw 17 4 faecal faecal JJ cord-332255-7sxioviw 17 5 suspension suspension NN cord-332255-7sxioviw 17 6 was be VBD cord-332255-7sxioviw 17 7 prepared prepare VBN cord-332255-7sxioviw 17 8 as as IN cord-332255-7sxioviw 17 9 a a DT cord-332255-7sxioviw 17 10 bacteria bacteria NNS cord-332255-7sxioviw 17 11 - - HYPH cord-332255-7sxioviw 17 12 free free JJ cord-332255-7sxioviw 17 13 20 20 CD cord-332255-7sxioviw 17 14 per per IN cord-332255-7sxioviw 17 15 cent cent NN cord-332255-7sxioviw 17 16 intestinal intestinal JJ cord-332255-7sxioviw 17 17 contents content NNS cord-332255-7sxioviw 17 18 filtrate filtrate NN cord-332255-7sxioviw 17 19 after after IN cord-332255-7sxioviw 17 20 one one CD cord-332255-7sxioviw 17 21 gnotobiotic gnotobiotic JJ cord-332255-7sxioviw 17 22 piglet piglet NN cord-332255-7sxioviw 17 23 passage passage NN cord-332255-7sxioviw 17 24 . . . cord-332255-7sxioviw 18 1 No no DT cord-332255-7sxioviw 18 2 virus virus NN cord-332255-7sxioviw 18 3 other other JJ cord-332255-7sxioviw 18 4 than than IN cord-332255-7sxioviw 18 5 rotavirus rotavirus NN cord-332255-7sxioviw 18 6 was be VBD cord-332255-7sxioviw 18 7 detected detect VBN cord-332255-7sxioviw 18 8 in in IN cord-332255-7sxioviw 18 9 the the DT cord-332255-7sxioviw 18 10 suspension suspension NN cord-332255-7sxioviw 18 11 by by IN cord-332255-7sxioviw 18 12 electron electron NN cord-332255-7sxioviw 18 13 microscopic microscopic JJ cord-332255-7sxioviw 18 14 examination examination NN cord-332255-7sxioviw 18 15 . . . cord-332255-7sxioviw 19 1 Piglets piglet NNS cord-332255-7sxioviw 19 2 were be VBD cord-332255-7sxioviw 19 3 inoculated inoculate VBN cord-332255-7sxioviw 19 4 orally orally RB cord-332255-7sxioviw 19 5 with with IN cord-332255-7sxioviw 19 6 2 2 CD cord-332255-7sxioviw 19 7 ml ml NNS cord-332255-7sxioviw 19 8 of of IN cord-332255-7sxioviw 19 9 the the DT cord-332255-7sxioviw 19 10 faecal faecal JJ cord-332255-7sxioviw 19 11 filtrate filtrate NN cord-332255-7sxioviw 19 12 . . . cord-332255-7sxioviw 20 1 .4nimals .4nimals NFP cord-332255-7sxioviw 21 1 Five five CD cord-332255-7sxioviw 21 2 P p NN cord-332255-7sxioviw 21 3 - - HYPH cord-332255-7sxioviw 21 4 day day NN cord-332255-7sxioviw 21 5 - - HYPH cord-332255-7sxioviw 21 6 old old JJ cord-332255-7sxioviw 21 7 gnotobiotic gnotobiotic JJ cord-332255-7sxioviw 21 8 piglets piglet NNS cord-332255-7sxioviw 21 9 were be VBD cord-332255-7sxioviw 21 10 used use VBN cord-332255-7sxioviw 21 11 . . . cord-332255-7sxioviw 22 1 They -PRON- PRP cord-332255-7sxioviw 22 2 were be VBD cord-332255-7sxioviw 22 3 kept keep VBN cord-332255-7sxioviw 22 4 at at IN cord-332255-7sxioviw 22 5 26 26 CD cord-332255-7sxioviw 22 6 " " `` cord-332255-7sxioviw 22 7 C C NNP cord-332255-7sxioviw 22 8 in in IN cord-332255-7sxioviw 22 9 individual individual JJ cord-332255-7sxioviw 22 10 metal metal NN cord-332255-7sxioviw 22 11 cages cage NNS cord-332255-7sxioviw 22 12 with with IN cord-332255-7sxioviw 22 13 positive positive JJ cord-332255-7sxioviw 22 14 pressure pressure NN cord-332255-7sxioviw 22 15 ventilation ventilation NN cord-332255-7sxioviw 22 16 . . . cord-332255-7sxioviw 23 1 Each each DT cord-332255-7sxioviw 23 2 was be VBD cord-332255-7sxioviw 23 3 given give VBN cord-332255-7sxioviw 23 4 2 2 CD cord-332255-7sxioviw 23 5 ml ml NN cord-332255-7sxioviw 23 6 of of IN cord-332255-7sxioviw 23 7 the the DT cord-332255-7sxioviw 23 8 rotavirus rotavirus JJ cord-332255-7sxioviw 23 9 suspension suspension NN cord-332255-7sxioviw 23 10 and and CC cord-332255-7sxioviw 23 11 they -PRON- PRP cord-332255-7sxioviw 23 12 were be VBD cord-332255-7sxioviw 23 13 killed kill VBN cord-332255-7sxioviw 23 14 at at IN cord-332255-7sxioviw 23 15 6 6 CD cord-332255-7sxioviw 23 16 , , , cord-332255-7sxioviw 23 17 12 12 CD cord-332255-7sxioviw 23 18 , , , cord-332255-7sxioviw 23 19 18 18 CD cord-332255-7sxioviw 23 20 , , , cord-332255-7sxioviw 23 21 24 24 CD cord-332255-7sxioviw 23 22 and and CC cord-332255-7sxioviw 23 23 48 48 CD cord-332255-7sxioviw 23 24 h h NN cord-332255-7sxioviw 23 25 after after IN cord-332255-7sxioviw 23 26 inoculation inoculation NN cord-332255-7sxioviw 23 27 . . . cord-332255-7sxioviw 24 1 Samples sample NNS cord-332255-7sxioviw 24 2 of of IN cord-332255-7sxioviw 24 3 the the DT cord-332255-7sxioviw 24 4 small small JJ cord-332255-7sxioviw 24 5 intestine intestine NN cord-332255-7sxioviw 24 6 were be VBD cord-332255-7sxioviw 24 7 removed remove VBN cord-332255-7sxioviw 24 8 under under IN cord-332255-7sxioviw 24 9 general general JJ cord-332255-7sxioviw 24 10 anaesthesia anaesthesia NN cord-332255-7sxioviw 24 11 from from IN cord-332255-7sxioviw 24 12 5 5 CD cord-332255-7sxioviw 24 13 sites site NNS cord-332255-7sxioviw 24 14 adjacent adjacent JJ cord-332255-7sxioviw 24 15 to to IN cord-332255-7sxioviw 24 16 those those DT cord-332255-7sxioviw 24 17 from from IN cord-332255-7sxioviw 24 18 which which WDT cord-332255-7sxioviw 24 19 samples sample NNS cord-332255-7sxioviw 24 20 had have VBD cord-332255-7sxioviw 24 21 been be VBN cord-332255-7sxioviw 24 22 taken take VBN cord-332255-7sxioviw 24 23 for for IN cord-332255-7sxioviw 24 24 histopathology histopathology NN cord-332255-7sxioviw 24 25 . . . cord-332255-7sxioviw 25 1 Samples sample NNS cord-332255-7sxioviw 25 2 were be VBD cord-332255-7sxioviw 25 3 fixed fix VBN cord-332255-7sxioviw 25 4 in in IN cord-332255-7sxioviw 25 5 2.5 2.5 CD cord-332255-7sxioviw 25 6 per per IN cord-332255-7sxioviw 25 7 cent cent NN cord-332255-7sxioviw 25 8 glutaraldehyde glutaraldehyde VBN cord-332255-7sxioviw 25 9 in in IN cord-332255-7sxioviw 25 10 0.1 0.1 CD cord-332255-7sxioviw 25 11 M m NN cord-332255-7sxioviw 25 12 phosphate phosphate NN cord-332255-7sxioviw 25 13 buffer buffer NN cord-332255-7sxioviw 25 14 , , , cord-332255-7sxioviw 25 15 pH pH NNP cord-332255-7sxioviw 25 16 7.2 7.2 CD cord-332255-7sxioviw 25 17 , , , cord-332255-7sxioviw 25 18 for for IN cord-332255-7sxioviw 25 19 2 2 CD cord-332255-7sxioviw 25 20 h h NN cord-332255-7sxioviw 25 21 at at IN cord-332255-7sxioviw 25 22 4 4 CD cord-332255-7sxioviw 26 1 " " `` cord-332255-7sxioviw 26 2 C. C. NNP cord-332255-7sxioviw 26 3 They -PRON- PRP cord-332255-7sxioviw 26 4 were be VBD cord-332255-7sxioviw 26 5 post post JJ cord-332255-7sxioviw 26 6 - - JJ cord-332255-7sxioviw 26 7 fixed fix VBN cord-332255-7sxioviw 26 8 in in IN cord-332255-7sxioviw 26 9 1 1 CD cord-332255-7sxioviw 26 10 per per IN cord-332255-7sxioviw 26 11 cent cent NN cord-332255-7sxioviw 26 12 osmium osmium NN cord-332255-7sxioviw 26 13 tetroxide tetroxide NN cord-332255-7sxioviw 26 14 in in IN cord-332255-7sxioviw 26 15 phosphate phosphate NN cord-332255-7sxioviw 26 16 buffer buffer NN cord-332255-7sxioviw 26 17 for for IN cord-332255-7sxioviw 26 18 1 1 CD cord-332255-7sxioviw 26 19 h h NN cord-332255-7sxioviw 26 20 at at IN cord-332255-7sxioviw 26 21 4 4 CD cord-332255-7sxioviw 26 22 ° ° NN cord-332255-7sxioviw 26 23 C c NN cord-332255-7sxioviw 26 24 . . . cord-332255-7sxioviw 27 1 The the DT cord-332255-7sxioviw 27 2 tissues tissue NNS cord-332255-7sxioviw 27 3 were be VBD cord-332255-7sxioviw 27 4 dehydrated dehydrate VBN cord-332255-7sxioviw 27 5 in in IN cord-332255-7sxioviw 27 6 a a DT cord-332255-7sxioviw 27 7 graded grade VBN cord-332255-7sxioviw 27 8 series series NN cord-332255-7sxioviw 27 9 of of IN cord-332255-7sxioviw 27 10 ethanol ethanol NN cord-332255-7sxioviw 27 11 and and CC cord-332255-7sxioviw 27 12 embedded embed VBN cord-332255-7sxioviw 27 13 in in IN cord-332255-7sxioviw 27 14 Epon Epon NNP cord-332255-7sxioviw 27 15 812 812 CD cord-332255-7sxioviw 27 16 . . . cord-332255-7sxioviw 28 1 Sections section NNS cord-332255-7sxioviw 28 2 were be VBD cord-332255-7sxioviw 28 3 cut cut VBN cord-332255-7sxioviw 28 4 with with IN cord-332255-7sxioviw 28 5 glass glass NN cord-332255-7sxioviw 28 6 knives knife NNS cord-332255-7sxioviw 28 7 , , , cord-332255-7sxioviw 28 8 stained stain VBN cord-332255-7sxioviw 28 9 with with IN cord-332255-7sxioviw 28 10 uranyl uranyl NN cord-332255-7sxioviw 28 11 acetate acetate NN cord-332255-7sxioviw 28 12 and and CC cord-332255-7sxioviw 28 13 lead lead NN cord-332255-7sxioviw 28 14 citrate citrate NN cord-332255-7sxioviw 28 15 , , , cord-332255-7sxioviw 28 16 and and CC cord-332255-7sxioviw 28 17 examined examine VBD cord-332255-7sxioviw 28 18 with with IN cord-332255-7sxioviw 28 19 a a DT cord-332255-7sxioviw 28 20 Nihon Nihon NNP cord-332255-7sxioviw 28 21 Denshi Denshi NNP cord-332255-7sxioviw 28 22 TEM tem NN cord-332255-7sxioviw 28 23 - - HYPH cord-332255-7sxioviw 28 24 IOOCX IOOCX NNP cord-332255-7sxioviw 28 25 electron electron NN cord-332255-7sxioviw 28 26 microscope microscope NN cord-332255-7sxioviw 28 27 . . . cord-332255-7sxioviw 29 1 jejunal jejunal NNP cord-332255-7sxioviw 29 2 and and CC cord-332255-7sxioviw 29 3 Seal Seal NNP cord-332255-7sxioviw 29 4 epithelial epithelial JJ cord-332255-7sxioviw 29 5 cells cell NNS cord-332255-7sxioviw 29 6 from from IN cord-332255-7sxioviw 29 7 piglets piglet NNS cord-332255-7sxioviw 29 8 6 6 CD cord-332255-7sxioviw 29 9 and and CC cord-332255-7sxioviw 29 10 12 12 CD cord-332255-7sxioviw 29 11 h h NN cord-332255-7sxioviw 29 12 after after IN cord-332255-7sxioviw 29 13 inoculation inoculation NN cord-332255-7sxioviw 29 14 showed show VBD cord-332255-7sxioviw 29 15 no no DT cord-332255-7sxioviw 29 16 morphological morphological JJ cord-332255-7sxioviw 29 17 alteration alteration NN cord-332255-7sxioviw 29 18 detectable detectable JJ cord-332255-7sxioviw 29 19 by by IN cord-332255-7sxioviw 29 20 ultrastructural ultrastructural JJ cord-332255-7sxioviw 29 21 examination examination NN cord-332255-7sxioviw 29 22 ; ; : cord-332255-7sxioviw 29 23 there there EX cord-332255-7sxioviw 29 24 was be VBD cord-332255-7sxioviw 29 25 no no DT cord-332255-7sxioviw 29 26 sign sign NN cord-332255-7sxioviw 29 27 of of IN cord-332255-7sxioviw 29 28 detachment detachment NN cord-332255-7sxioviw 29 29 or or CC cord-332255-7sxioviw 29 30 desquamation desquamation NN cord-332255-7sxioviw 29 31 of of IN cord-332255-7sxioviw 29 32 the the DT cord-332255-7sxioviw 29 33 villi villi NN cord-332255-7sxioviw 29 34 . . . cord-332255-7sxioviw 30 1 Microvilli Microvilli NNP cord-332255-7sxioviw 30 2 were be VBD cord-332255-7sxioviw 30 3 intact intact JJ cord-332255-7sxioviw 30 4 and and CC cord-332255-7sxioviw 30 5 contained contain VBD cord-332255-7sxioviw 30 6 a a DT cord-332255-7sxioviw 30 7 prominent prominent JJ cord-332255-7sxioviw 30 8 nucleus nucleus NN cord-332255-7sxioviw 30 9 , , , cord-332255-7sxioviw 30 10 abundant abundant JJ cord-332255-7sxioviw 30 11 mitochondria mitochondrion NNS cord-332255-7sxioviw 30 12 , , , cord-332255-7sxioviw 30 13 and and CC cord-332255-7sxioviw 30 14 rough rough JJ cord-332255-7sxioviw 30 15 endoplasmic endoplasmic NN cord-332255-7sxioviw 30 16 reticulum reticulum NN cord-332255-7sxioviw 30 17 ( ( -LRB- cord-332255-7sxioviw 30 18 RER RER NNP cord-332255-7sxioviw 30 19 ) ) -RRB- cord-332255-7sxioviw 30 20 . . . cord-332255-7sxioviw 31 1 However however RB cord-332255-7sxioviw 31 2 , , , cord-332255-7sxioviw 31 3 virus virus NN cord-332255-7sxioviw 31 4 particles particle NNS cord-332255-7sxioviw 31 5 ranging range VBG cord-332255-7sxioviw 31 6 from from IN cord-332255-7sxioviw 31 7 65 65 CD cord-332255-7sxioviw 31 8 to to TO cord-332255-7sxioviw 31 9 75 75 CD cord-332255-7sxioviw 31 10 nm nm NN cord-332255-7sxioviw 31 11 in in IN cord-332255-7sxioviw 31 12 diameter diameter NN cord-332255-7sxioviw 31 13 were be VBD cord-332255-7sxioviw 31 14 detected detect VBN cord-332255-7sxioviw 31 15 in in IN cord-332255-7sxioviw 31 16 a a DT cord-332255-7sxioviw 31 17 few few JJ cord-332255-7sxioviw 31 18 absorptive absorptive JJ cord-332255-7sxioviw 31 19 cells cell NNS cord-332255-7sxioviw 31 20 of of IN cord-332255-7sxioviw 31 21 a a DT cord-332255-7sxioviw 31 22 sample sample NN cord-332255-7sxioviw 31 23 ofjejunum ofjejunum NN cord-332255-7sxioviw 31 24 collected collect VBN cord-332255-7sxioviw 31 25 at at IN cord-332255-7sxioviw 31 26 12 12 CD cord-332255-7sxioviw 31 27 h. h. NN cord-332255-7sxioviw 31 28 Particles particle NNS cord-332255-7sxioviw 31 29 were be VBD cord-332255-7sxioviw 31 30 observed observe VBN cord-332255-7sxioviw 31 31 on on IN cord-332255-7sxioviw 31 32 the the DT cord-332255-7sxioviw 31 33 microvillar microvillar JJ cord-332255-7sxioviw 31 34 border border NN cord-332255-7sxioviw 31 35 or or CC cord-332255-7sxioviw 31 36 between between IN cord-332255-7sxioviw 31 37 the the DT cord-332255-7sxioviw 31 38 microviIli microviIli NNP cord-332255-7sxioviw 31 39 where where WRB cord-332255-7sxioviw 31 40 they -PRON- PRP cord-332255-7sxioviw 31 41 were be VBD cord-332255-7sxioviw 31 42 often often RB cord-332255-7sxioviw 31 43 located locate VBN cord-332255-7sxioviw 31 44 in in IN cord-332255-7sxioviw 31 45 rows row NNS cord-332255-7sxioviw 31 46 ( ( -LRB- cord-332255-7sxioviw 31 47 Fig Fig NNP cord-332255-7sxioviw 31 48 . . NNP cord-332255-7sxioviw 31 49 1 1 CD cord-332255-7sxioviw 31 50 ) ) -RRB- cord-332255-7sxioviw 31 51 . . . cord-332255-7sxioviw 32 1 Individual individual JJ cord-332255-7sxioviw 32 2 or or CC cord-332255-7sxioviw 32 3 small small JJ cord-332255-7sxioviw 32 4 numbers number NNS cord-332255-7sxioviw 32 5 of of IN cord-332255-7sxioviw 32 6 particles particle NNS cord-332255-7sxioviw 32 7 were be VBD cord-332255-7sxioviw 32 8 found find VBN cord-332255-7sxioviw 32 9 inside inside IN cord-332255-7sxioviw 32 10 vesicles vesicle NNS cord-332255-7sxioviw 32 11 located locate VBN cord-332255-7sxioviw 32 12 in in IN cord-332255-7sxioviw 32 13 the the DT cord-332255-7sxioviw 32 14 terminal terminal NN cord-332255-7sxioviw 32 15 web web NN cord-332255-7sxioviw 32 16 area area NN cord-332255-7sxioviw 32 17 or or CC cord-332255-7sxioviw 32 18 in in IN cord-332255-7sxioviw 32 19 the the DT cord-332255-7sxioviw 32 20 upper upper JJ cord-332255-7sxioviw 32 21 region region NN cord-332255-7sxioviw 32 22 of of IN cord-332255-7sxioviw 32 23 the the DT cord-332255-7sxioviw 32 24 apical apical JJ cord-332255-7sxioviw 32 25 cytoplasm cytoplasm NN cord-332255-7sxioviw 32 26 ( ( -LRB- cord-332255-7sxioviw 32 27 Fig fig NN cord-332255-7sxioviw 32 28 . . NNP cord-332255-7sxioviw 32 29 2 2 CD cord-332255-7sxioviw 32 30 ) ) -RRB- cord-332255-7sxioviw 32 31 . . . cord-332255-7sxioviw 33 1 Eighteen eighteen CD cord-332255-7sxioviw 33 2 hours hour NNS cord-332255-7sxioviw 33 3 after after IN cord-332255-7sxioviw 33 4 infection infection NN cord-332255-7sxioviw 33 5 most most JJS cord-332255-7sxioviw 33 6 of of IN cord-332255-7sxioviw 33 7 the the DT cord-332255-7sxioviw 33 8 absorptive absorptive JJ cord-332255-7sxioviw 33 9 epithelial epithelial JJ cord-332255-7sxioviw 33 10 cells cell NNS cord-332255-7sxioviw 33 11 in in IN cord-332255-7sxioviw 33 12 the the DT cord-332255-7sxioviw 33 13 jejunum jejunum NN cord-332255-7sxioviw 33 14 and and CC cord-332255-7sxioviw 33 15 ileum ileum NN cord-332255-7sxioviw 33 16 were be VBD cord-332255-7sxioviw 33 17 slightly slightly RB cord-332255-7sxioviw 33 18 swollen swollen JJ cord-332255-7sxioviw 33 19 . . . cord-332255-7sxioviw 34 1 Most Most JJS cord-332255-7sxioviw 34 2 of of IN cord-332255-7sxioviw 34 3 the the DT cord-332255-7sxioviw 34 4 microvilli microvilli NN cord-332255-7sxioviw 34 5 of of IN cord-332255-7sxioviw 34 6 the the DT cord-332255-7sxioviw 34 7 brush brush NN cord-332255-7sxioviw 34 8 border border NN cord-332255-7sxioviw 34 9 were be VBD cord-332255-7sxioviw 34 10 normal normal JJ cord-332255-7sxioviw 34 11 in in IN cord-332255-7sxioviw 34 12 length length NN cord-332255-7sxioviw 34 13 , , , cord-332255-7sxioviw 34 14 but but CC cord-332255-7sxioviw 34 15 some some DT cord-332255-7sxioviw 34 16 were be VBD cord-332255-7sxioviw 34 17 short short JJ cord-332255-7sxioviw 34 18 , , , cord-332255-7sxioviw 34 19 thick thick JJ cord-332255-7sxioviw 34 20 and and CC cord-332255-7sxioviw 34 21 irregular irregular JJ cord-332255-7sxioviw 34 22 . . . cord-332255-7sxioviw 35 1 These these DT cord-332255-7sxioviw 35 2 infected infected JJ cord-332255-7sxioviw 35 3 cells cell NNS cord-332255-7sxioviw 35 4 had have VBD cord-332255-7sxioviw 35 5 lost lose VBN cord-332255-7sxioviw 35 6 most most JJS cord-332255-7sxioviw 35 7 of of IN cord-332255-7sxioviw 35 8 their -PRON- PRP$ cord-332255-7sxioviw 35 9 staining stain VBG cord-332255-7sxioviw 35 10 density density NN cord-332255-7sxioviw 35 11 and and CC cord-332255-7sxioviw 35 12 contained contain VBD cord-332255-7sxioviw 35 13 many many JJ cord-332255-7sxioviw 35 14 virus virus NN cord-332255-7sxioviw 35 15 particles particle NNS cord-332255-7sxioviw 35 16 within within IN cord-332255-7sxioviw 35 17 the the DT cord-332255-7sxioviw 35 18 distended distended JJ cord-332255-7sxioviw 35 19 RER rer NN cord-332255-7sxioviw 35 20 . . . cord-332255-7sxioviw 36 1 In in IN cord-332255-7sxioviw 36 2 some some DT cord-332255-7sxioviw 36 3 sections section NNS cord-332255-7sxioviw 36 4 , , , cord-332255-7sxioviw 36 5 effete effete JJ cord-332255-7sxioviw 36 6 cells cell NNS cord-332255-7sxioviw 36 7 containing contain VBG cord-332255-7sxioviw 36 8 viral viral JJ cord-332255-7sxioviw 36 9 particles particle NNS cord-332255-7sxioviw 36 10 were be VBD cord-332255-7sxioviw 36 11 found find VBN cord-332255-7sxioviw 36 12 in in IN cord-332255-7sxioviw 36 13 the the DT cord-332255-7sxioviw 36 14 process process NN cord-332255-7sxioviw 36 15 of of IN cord-332255-7sxioviw 36 16 being be VBG cord-332255-7sxioviw 36 17 destroyed destroy VBN cord-332255-7sxioviw 36 18 ( ( -LRB- cord-332255-7sxioviw 36 19 Figs Figs NNP cord-332255-7sxioviw 36 20 3 3 CD cord-332255-7sxioviw 36 21 and and CC cord-332255-7sxioviw 36 22 4 4 CD cord-332255-7sxioviw 36 23 ) ) -RRB- cord-332255-7sxioviw 36 24 . . . cord-332255-7sxioviw 37 1 iZ iZ NNP cord-332255-7sxioviw 38 1 few few JJ cord-332255-7sxioviw 38 2 goblet goblet NN cord-332255-7sxioviw 38 3 cells cell NNS cord-332255-7sxioviw 38 4 also also RB cord-332255-7sxioviw 38 5 contained contain VBD cord-332255-7sxioviw 38 6 virus virus NN cord-332255-7sxioviw 38 7 particles particle NNS cord-332255-7sxioviw 38 8 ( ( -LRB- cord-332255-7sxioviw 38 9 Fig fig NN cord-332255-7sxioviw 38 10 . . . cord-332255-7sxioviw 38 11 5 5 CD cord-332255-7sxioviw 38 12 ) ) -RRB- cord-332255-7sxioviw 38 13 . . . cord-332255-7sxioviw 39 1 At at IN cord-332255-7sxioviw 39 2 24 24 CD cord-332255-7sxioviw 39 3 h h NN cord-332255-7sxioviw 39 4 after after IN cord-332255-7sxioviw 39 5 infection infection NN cord-332255-7sxioviw 39 6 , , , cord-332255-7sxioviw 39 7 some some DT cord-332255-7sxioviw 39 8 of of IN cord-332255-7sxioviw 39 9 the the DT cord-332255-7sxioviw 39 10 absorptive absorptive JJ cord-332255-7sxioviw 39 11 epithelial epithelial JJ cord-332255-7sxioviw 39 12 cells cell NNS cord-332255-7sxioviw 39 13 were be VBD cord-332255-7sxioviw 39 14 becoming become VBG cord-332255-7sxioviw 39 15 degenerate degenerate JJ cord-332255-7sxioviw 39 16 . . . cord-332255-7sxioviw 40 1 In in IN cord-332255-7sxioviw 40 2 the the DT cord-332255-7sxioviw 40 3 jejunum jejunum NN cord-332255-7sxioviw 40 4 , , , cord-332255-7sxioviw 40 5 the the DT cord-332255-7sxioviw 40 6 degenerating degenerate VBG cord-332255-7sxioviw 40 7 cells cell NNS cord-332255-7sxioviw 40 8 were be VBD cord-332255-7sxioviw 40 9 rounded round VBN cord-332255-7sxioviw 40 10 , , , cord-332255-7sxioviw 40 11 swollen swollen JJ cord-332255-7sxioviw 40 12 , , , cord-332255-7sxioviw 40 13 and and CC cord-332255-7sxioviw 40 14 had have VBD cord-332255-7sxioviw 40 15 lost lose VBN cord-332255-7sxioviw 40 16 some some DT cord-332255-7sxioviw 40 17 of of IN cord-332255-7sxioviw 40 18 their -PRON- PRP$ cord-332255-7sxioviw 40 19 staining staining NN cord-332255-7sxioviw 40 20 intensity intensity NN cord-332255-7sxioviw 40 21 . . . cord-332255-7sxioviw 41 1 They -PRON- PRP cord-332255-7sxioviw 41 2 had have VBD cord-332255-7sxioviw 41 3 large large JJ cord-332255-7sxioviw 41 4 lipid lipid NN cord-332255-7sxioviw 41 5 droplets droplet NNS cord-332255-7sxioviw 41 6 and and CC cord-332255-7sxioviw 41 7 an an DT cord-332255-7sxioviw 41 8 RER rer NN cord-332255-7sxioviw 41 9 distended distend VBN cord-332255-7sxioviw 41 10 by by IN cord-332255-7sxioviw 41 11 vacuoles vacuole NNS cord-332255-7sxioviw 41 12 . . . cord-332255-7sxioviw 42 1 These these DT cord-332255-7sxioviw 42 2 degenerated degenerate VBN cord-332255-7sxioviw 42 3 cells cell NNS cord-332255-7sxioviw 42 4 contained contain VBD cord-332255-7sxioviw 42 5 few few JJ cord-332255-7sxioviw 42 6 viral viral JJ cord-332255-7sxioviw 42 7 particles particle NNS cord-332255-7sxioviw 42 8 ( ( -LRB- cord-332255-7sxioviw 42 9 Fig Fig NNP cord-332255-7sxioviw 42 10 . . . cord-332255-7sxioviw 42 11 6 6 CD cord-332255-7sxioviw 42 12 ) ) -RRB- cord-332255-7sxioviw 42 13 . . . cord-332255-7sxioviw 43 1 In in IN cord-332255-7sxioviw 43 2 some some DT cord-332255-7sxioviw 43 3 sections section NNS cord-332255-7sxioviw 43 4 , , , cord-332255-7sxioviw 43 5 the the DT cord-332255-7sxioviw 43 6 infected infected JJ cord-332255-7sxioviw 43 7 cells cell NNS cord-332255-7sxioviw 43 8 appeared appear VBD cord-332255-7sxioviw 43 9 to to TO cord-332255-7sxioviw 43 10 be be VB cord-332255-7sxioviw 43 11 detaching detach VBG cord-332255-7sxioviw 43 12 from from IN cord-332255-7sxioviw 43 13 adjacent adjacent JJ cord-332255-7sxioviw 43 14 epithelial epithelial JJ cord-332255-7sxioviw 43 15 cells cell NNS cord-332255-7sxioviw 43 16 and and CC cord-332255-7sxioviw 43 17 being be VBG cord-332255-7sxioviw 43 18 shed shed VBN cord-332255-7sxioviw 43 19 into into IN cord-332255-7sxioviw 43 20 the the DT cord-332255-7sxioviw 43 21 lumen lumen NN cord-332255-7sxioviw 43 22 ( ( -LRB- cord-332255-7sxioviw 43 23 Fig Fig NNP cord-332255-7sxioviw 43 24 . . NNP cord-332255-7sxioviw 43 25 7 7 CD cord-332255-7sxioviw 43 26 ) ) -RRB- cord-332255-7sxioviw 43 27 . . . cord-332255-7sxioviw 44 1 Man man NN cord-332255-7sxioviw 44 2 ) ) -RRB- cord-332255-7sxioviw 44 3 viral viral JJ cord-332255-7sxioviw 44 4 particles particle NNS cord-332255-7sxioviw 44 5 were be VBD cord-332255-7sxioviw 44 6 seen see VBN cord-332255-7sxioviw 44 7 within within IN cord-332255-7sxioviw 44 8 the the DT cord-332255-7sxioviw 44 9 distended distended JJ cord-332255-7sxioviw 44 10 RER rer NN cord-332255-7sxioviw 44 11 . . . cord-332255-7sxioviw 45 1 They -PRON- PRP cord-332255-7sxioviw 45 2 were be VBD cord-332255-7sxioviw 45 3 classified classify VBN cord-332255-7sxioviw 45 4 as as IN cord-332255-7sxioviw 45 5 3 3 CD cord-332255-7sxioviw 45 6 types type NNS cord-332255-7sxioviw 45 7 ; ; , cord-332255-7sxioviw 45 8 enveloped envelop VBN cord-332255-7sxioviw 45 9 , , , cord-332255-7sxioviw 45 10 non non JJ cord-332255-7sxioviw 45 11 - - JJ cord-332255-7sxioviw 45 12 enveloped enveloped JJ cord-332255-7sxioviw 45 13 particles particle NNS cord-332255-7sxioviw 45 14 and and CC cord-332255-7sxioviw 45 15 nucleoids nucleoid NNS cord-332255-7sxioviw 45 16 . . . cord-332255-7sxioviw 46 1 Enveloped envelop VBN cord-332255-7sxioviw 46 2 particles particle NNS cord-332255-7sxioviw 46 3 were be VBD cord-332255-7sxioviw 46 4 70 70 CD cord-332255-7sxioviw 46 5 to to TO cord-332255-7sxioviw 46 6 80 80 CD cord-332255-7sxioviw 46 7 nm nm NN cord-332255-7sxioviw 46 8 in in IN cord-332255-7sxioviw 46 9 size size NN cord-332255-7sxioviw 46 10 and and CC cord-332255-7sxioviw 46 11 some some DT cord-332255-7sxioviw 46 12 appeared appear VBD cord-332255-7sxioviw 46 13 to to TO cord-332255-7sxioviw 46 14 have have VB cord-332255-7sxioviw 46 15 acquired acquire VBN cord-332255-7sxioviw 46 16 an an DT cord-332255-7sxioviw 46 17 outer outer JJ cord-332255-7sxioviw 46 18 shell shell NN cord-332255-7sxioviw 46 19 by by IN cord-332255-7sxioviw 46 20 , , , cord-332255-7sxioviw 46 21 budding bud VBG cord-332255-7sxioviw 46 22 through through IN cord-332255-7sxioviw 46 23 the the DT cord-332255-7sxioviw 46 24 endoplasmic endoplasmic NN cord-332255-7sxioviw 46 25 reticulum reticulum NN cord-332255-7sxioviw 46 26 . . . cord-332255-7sxioviw 47 1 Non Non NNS cord-332255-7sxioviw 47 2 - - JJ cord-332255-7sxioviw 47 3 enveloped envelop VBN cord-332255-7sxioviw 47 4 particles particle NNS cord-332255-7sxioviw 47 5 were be VBD cord-332255-7sxioviw 47 6 50 50 CD cord-332255-7sxioviw 47 7 to to TO cord-332255-7sxioviw 47 8 65 65 CD cord-332255-7sxioviw 47 9 nm nm NN cord-332255-7sxioviw 47 10 in in IN cord-332255-7sxioviw 47 11 size size NN cord-332255-7sxioviw 47 12 . . . cord-332255-7sxioviw 48 1 Both both DT cord-332255-7sxioviw 48 2 types type NNS cord-332255-7sxioviw 48 3 of of IN cord-332255-7sxioviw 48 4 viral viral JJ cord-332255-7sxioviw 48 5 particles particle NNS cord-332255-7sxioviw 48 6 had have VBD cord-332255-7sxioviw 48 7 an an DT cord-332255-7sxioviw 48 8 electron electron NN cord-332255-7sxioviw 48 9 - - HYPH cord-332255-7sxioviw 48 10 dense dense JJ cord-332255-7sxioviw 48 11 core core NN cord-332255-7sxioviw 48 12 measuring measure VBG cord-332255-7sxioviw 48 13 20 20 CD cord-332255-7sxioviw 48 14 to to TO cord-332255-7sxioviw 48 15 30 30 CD cord-332255-7sxioviw 48 16 nm nm NN cord-332255-7sxioviw 48 17 . . . cord-332255-7sxioviw 49 1 In in IN cord-332255-7sxioviw 49 2 the the DT cord-332255-7sxioviw 49 3 cytoplasm cytoplasm NN cord-332255-7sxioviw 49 4 of of IN cord-332255-7sxioviw 49 5 the the DT cord-332255-7sxioviw 49 6 infected infected JJ cord-332255-7sxioviw 49 7 cells cell NNS cord-332255-7sxioviw 49 8 , , , cord-332255-7sxioviw 49 9 non non JJ cord-332255-7sxioviw 49 10 - - NN cord-332255-7sxioviw 49 11 membrane membrane JJ cord-332255-7sxioviw 49 12 bound bind VBN cord-332255-7sxioviw 49 13 , , , cord-332255-7sxioviw 49 14 granular granular JJ cord-332255-7sxioviw 49 15 matrices matrix NNS cord-332255-7sxioviw 49 16 containing contain VBG cord-332255-7sxioviw 49 17 an an DT cord-332255-7sxioviw 49 18 electron electron NN cord-332255-7sxioviw 49 19 - - HYPH cord-332255-7sxioviw 49 20 dense dense JJ cord-332255-7sxioviw 49 21 virus virus NN cord-332255-7sxioviw 49 22 core core NN cord-332255-7sxioviw 49 23 were be VBD cord-332255-7sxioviw 49 24 present present JJ cord-332255-7sxioviw 50 1 ( ( -LRB- cord-332255-7sxioviw 50 2 Fig Fig NNP cord-332255-7sxioviw 50 3 . . . cord-332255-7sxioviw 50 4 8) 8) NNP cord-332255-7sxioviw 50 5 . . . cord-332255-7sxioviw 51 1 In in IN cord-332255-7sxioviw 51 2 the the DT cord-332255-7sxioviw 51 3 ileum ileum NN cord-332255-7sxioviw 51 4 , , , cord-332255-7sxioviw 51 5 most most JJS cord-332255-7sxioviw 51 6 of of IN cord-332255-7sxioviw 51 7 the the DT cord-332255-7sxioviw 51 8 epithelial epithelial JJ cord-332255-7sxioviw 51 9 cells cell NNS cord-332255-7sxioviw 51 10 were be VBD cord-332255-7sxioviw 51 11 desquamated desquamate VBN cord-332255-7sxioviw 51 12 from from IN cord-332255-7sxioviw 51 13 the the DT cord-332255-7sxioviw 51 14 villi villi NN cord-332255-7sxioviw 51 15 and and CC cord-332255-7sxioviw 51 16 a a DT cord-332255-7sxioviw 51 17 small small JJ cord-332255-7sxioviw 51 18 number number NN cord-332255-7sxioviw 51 19 of of IN cord-332255-7sxioviw 51 20 neutrophils neutrophil NNS cord-332255-7sxioviw 51 21 was be VBD cord-332255-7sxioviw 51 22 observed observe VBN cord-332255-7sxioviw 51 23 in in IN cord-332255-7sxioviw 51 24 the the DT cord-332255-7sxioviw 51 25 submucosa submucosa NNP cord-332255-7sxioviw 51 26 . . . cord-332255-7sxioviw 52 1 At at IN cord-332255-7sxioviw 52 2 48 48 CD cord-332255-7sxioviw 52 3 h h NN cord-332255-7sxioviw 52 4 after after IN cord-332255-7sxioviw 52 5 infection infection NN cord-332255-7sxioviw 52 6 , , , cord-332255-7sxioviw 52 7 disruption disruption NN cord-332255-7sxioviw 52 8 and and CC cord-332255-7sxioviw 52 9 desquamation desquamation NN cord-332255-7sxioviw 52 10 of of IN cord-332255-7sxioviw 52 11 the the DT cord-332255-7sxioviw 52 12 cells cell NNS cord-332255-7sxioviw 52 13 were be VBD cord-332255-7sxioviw 52 14 still still RB cord-332255-7sxioviw 52 15 present present JJ cord-332255-7sxioviw 52 16 in in IN cord-332255-7sxioviw 52 17 a a DT cord-332255-7sxioviw 52 18 few few JJ cord-332255-7sxioviw 52 19 areas area NNS cord-332255-7sxioviw 52 20 of of IN cord-332255-7sxioviw 52 21 villi villi NN cord-332255-7sxioviw 52 22 . . . cord-332255-7sxioviw 53 1 At at IN cord-332255-7sxioviw 53 2 this this DT cord-332255-7sxioviw 53 3 time time NN cord-332255-7sxioviw 53 4 the the DT cord-332255-7sxioviw 53 5 short short JJ cord-332255-7sxioviw 53 6 villi villi NN cord-332255-7sxioviw 53 7 were be VBD cord-332255-7sxioviw 53 8 covered cover VBN cord-332255-7sxioviw 53 9 with with IN cord-332255-7sxioviw 53 10 a a DT cord-332255-7sxioviw 53 11 type type NN cord-332255-7sxioviw 53 12 of of IN cord-332255-7sxioviw 53 13 cell cell NN cord-332255-7sxioviw 53 14 which which WDT cord-332255-7sxioviw 53 15 was be VBD cord-332255-7sxioviw 53 16 ultrastructurally ultrastructurally RB cord-332255-7sxioviw 53 17 different different JJ cord-332255-7sxioviw 53 18 from from IN cord-332255-7sxioviw 53 19 any any DT cord-332255-7sxioviw 53 20 of of IN cord-332255-7sxioviw 53 21 those those DT cord-332255-7sxioviw 53 22 seen see VBN cord-332255-7sxioviw 53 23 on on IN cord-332255-7sxioviw 53 24 tht tht NNP cord-332255-7sxioviw 53 25 villi villi NNP cord-332255-7sxioviw 53 26 in in IN cord-332255-7sxioviw 53 27 the the DT cord-332255-7sxioviw 53 28 earlier early JJR cord-332255-7sxioviw 53 29 stages stage NNS cord-332255-7sxioviw 53 30 . . . cord-332255-7sxioviw 54 1 They -PRON- PRP cord-332255-7sxioviw 54 2 were be VBD cord-332255-7sxioviw 54 3 flat flat JJ cord-332255-7sxioviw 54 4 to to IN cord-332255-7sxioviw 54 5 cuboida1 cuboida1 NN cord-332255-7sxioviw 54 6 , , , cord-332255-7sxioviw 54 7 contained contain VBD cord-332255-7sxioviw 54 8 oval oval JJ cord-332255-7sxioviw 54 9 nuclei nucleus NNS cord-332255-7sxioviw 54 10 lying lie VBG cord-332255-7sxioviw 54 11 parallel parallel JJ cord-332255-7sxioviw 54 12 to to IN cord-332255-7sxioviw 54 13 the the DT cord-332255-7sxioviw 54 14 axis axis NN cord-332255-7sxioviw 54 15 of of IN cord-332255-7sxioviw 54 16 the the DT cord-332255-7sxioviw 54 17 villi villi NN cord-332255-7sxioviw 54 18 and and CC cord-332255-7sxioviw 54 19 were be VBD cord-332255-7sxioviw 54 20 closely closely RB cord-332255-7sxioviw 54 21 applied apply VBN cord-332255-7sxioviw 54 22 to to IN cord-332255-7sxioviw 54 23 the the DT cord-332255-7sxioviw 54 24 basement basement NN cord-332255-7sxioviw 54 25 membrane membrane NN cord-332255-7sxioviw 54 26 . . . cord-332255-7sxioviw 55 1 Their -PRON- PRP$ cord-332255-7sxioviw 55 2 : : : cord-332255-7sxioviw 55 3 te te NNP cord-332255-7sxioviw 55 4 . . . cord-332255-7sxioviw 56 1 ( ( -LRB- cord-332255-7sxioviw 56 2 Fig Fig NNP cord-332255-7sxioviw 56 3 . . . cord-332255-7sxioviw 56 4 9 9 CD cord-332255-7sxioviw 56 5 ) ) -RRB- cord-332255-7sxioviw 56 6 . . . cord-332255-7sxioviw 57 1 Viral viral JJ cord-332255-7sxioviw 57 2 particles particle NNS cord-332255-7sxioviw 57 3 ' ' '' cord-332255-7sxioviw 57 4 were be VBD cord-332255-7sxioviw 57 5 not not RB cord-332255-7sxioviw 57 6 detected'&% detected'&% NNP cord-332255-7sxioviw 57 7 & & CC cord-332255-7sxioviw 57 8 apparently apparently RB cord-332255-7sxioviw 57 9 newly newly RB cord-332255-7sxioviw 57 10 produced produce VBN cord-332255-7sxioviw 57 11 and and CC cord-332255-7sxioviw 57 12 undifferentiated undifferentiated JJ cord-332255-7sxioviw 57 13 cells cell NNS cord-332255-7sxioviw 57 14 . . . cord-332255-7sxioviw 58 1 The the DT cord-332255-7sxioviw 58 2 present present JJ cord-332255-7sxioviw 58 3 EM EM NNP cord-332255-7sxioviw 58 4 study study NN cord-332255-7sxioviw 58 5 has have VBZ cord-332255-7sxioviw 58 6 established establish VBN cord-332255-7sxioviw 58 7 that that IN cord-332255-7sxioviw 58 8 the the DT cord-332255-7sxioviw 58 9 porcine porcine JJ cord-332255-7sxioviw 58 10 rotavirus rotavirus NN cord-332255-7sxioviw 58 11 becomes become VBZ cord-332255-7sxioviw 58 12 localized localize VBN cord-332255-7sxioviw 58 13 within within IN cord-332255-7sxioviw 58 14 the the DT cord-332255-7sxioviw 58 15 epithelial epithelial NN cord-332255-7sxioviw 58 16 and and CC cord-332255-7sxioviw 58 17 goblet goblet NN cord-332255-7sxioviw 58 18 cells cell NNS cord-332255-7sxioviw 58 19 of of IN cord-332255-7sxioviw 58 20 the the DT cord-332255-7sxioviw 58 21 small small JJ cord-332255-7sxioviw 58 22 intestine intestine NN cord-332255-7sxioviw 58 23 of of IN cord-332255-7sxioviw 58 24 piglets piglet NNS cord-332255-7sxioviw 58 25 . . . cord-332255-7sxioviw 59 1 The the DT cord-332255-7sxioviw 59 2 viral viral JJ cord-332255-7sxioviw 59 3 particles particle NNS cord-332255-7sxioviw 59 4 , , , cord-332255-7sxioviw 59 5 in in IN cord-332255-7sxioviw 59 6 the the DT cord-332255-7sxioviw 59 7 form form NN cord-332255-7sxioviw 59 8 of of IN cord-332255-7sxioviw 59 9 double double RB cord-332255-7sxioviw 59 10 - - HYPH cord-332255-7sxioviw 59 11 shelled shell VBN cord-332255-7sxioviw 59 12 or or CC cord-332255-7sxioviw 59 13 enveloped envelop VBN cord-332255-7sxioviw 59 14 particles particle NNS cord-332255-7sxioviw 59 15 ( ( -LRB- cord-332255-7sxioviw 59 16 70 70 CD cord-332255-7sxioviw 59 17 to to TO cord-332255-7sxioviw 59 18 85 85 CD cord-332255-7sxioviw 59 19 nm nm NN cord-332255-7sxioviw 59 20 ) ) -RRB- cord-332255-7sxioviw 59 21 , , , cord-332255-7sxioviw 59 22 single single RB cord-332255-7sxioviw 59 23 - - HYPH cord-332255-7sxioviw 59 24 shelled shell VBN cord-332255-7sxioviw 59 25 particles particle NNS cord-332255-7sxioviw 59 26 ( ( -LRB- cord-332255-7sxioviw 59 27 60 60 CD cord-332255-7sxioviw 59 28 to to TO cord-332255-7sxioviw 59 29 70 70 CD cord-332255-7sxioviw 59 30 nm nm NN cord-332255-7sxioviw 59 31 ) ) -RRB- cord-332255-7sxioviw 59 32 , , , cord-332255-7sxioviw 59 33 and and CC cord-332255-7sxioviw 59 34 small small JJ cord-332255-7sxioviw 59 35 cores core NNS cord-332255-7sxioviw 59 36 or or CC cord-332255-7sxioviw 59 37 nucleoids nucleoid NNS cord-332255-7sxioviw 59 38 ( ( -LRB- cord-332255-7sxioviw 59 39 25 25 CD cord-332255-7sxioviw 59 40 to to TO cord-332255-7sxioviw 59 41 30 30 CD cord-332255-7sxioviw 59 42 nm nm NN cord-332255-7sxioviw 59 43 ) ) -RRB- cord-332255-7sxioviw 59 44 , , , cord-332255-7sxioviw 59 45 were be VBD cord-332255-7sxioviw 59 46 readily readily RB cord-332255-7sxioviw 59 47 seen see VBN cord-332255-7sxioviw 59 48 in in IN cord-332255-7sxioviw 59 49 the the DT cord-332255-7sxioviw 59 50 epithelium epithelium NN cord-332255-7sxioviw 59 51 of of IN cord-332255-7sxioviw 59 52 the the DT cord-332255-7sxioviw 59 53 piglets piglet NNS cord-332255-7sxioviw 59 54 killed kill VBD cord-332255-7sxioviw 59 55 18 18 CD cord-332255-7sxioviw 59 56 h h NN cord-332255-7sxioviw 59 57 after after IN cord-332255-7sxioviw 59 58 infection infection NN cord-332255-7sxioviw 59 59 . . . cord-332255-7sxioviw 60 1 Thereafter thereafter RB cord-332255-7sxioviw 60 2 , , , cord-332255-7sxioviw 60 3 infected infected JJ cord-332255-7sxioviw 60 4 cells cell NNS cord-332255-7sxioviw 60 5 were be VBD cord-332255-7sxioviw 60 6 only only RB cord-332255-7sxioviw 60 7 rarely rarely RB cord-332255-7sxioviw 60 8 observed observe VBN cord-332255-7sxioviw 60 9 . . . cord-332255-7sxioviw 61 1 These these DT cord-332255-7sxioviw 61 2 observations observation NNS cord-332255-7sxioviw 61 3 agreed agree VBD cord-332255-7sxioviw 61 4 with with IN cord-332255-7sxioviw 61 5 previous previous JJ cord-332255-7sxioviw 61 6 reports report NNS cord-332255-7sxioviw 61 7 by by IN cord-332255-7sxioviw 61 8 Adams Adams NNP cord-332255-7sxioviw 61 9 and and CC cord-332255-7sxioviw 61 10 Kraft Kraft NNP cord-332255-7sxioviw 61 11 ( ( -LRB- cord-332255-7sxioviw 61 12 1976 1976 CD cord-332255-7sxioviw 61 13 ) ) -RRB- cord-332255-7sxioviw 61 14 ) ) -RRB- cord-332255-7sxioviw 62 1 Chasey Chasey NNP cord-332255-7sxioviw 62 2 i i NNP cord-332255-7sxioviw 62 3 1977 1977 CD cord-332255-7sxioviw 62 4 ) ) -RRB- cord-332255-7sxioviw 62 5 ) ) -RRB- cord-332255-7sxioviw 63 1 Esparza Esparza NNP cord-332255-7sxioviw 63 2 , , , cord-332255-7sxioviw 63 3 Gorziglia Gorziglia NNP cord-332255-7sxioviw 63 4 , , , cord-332255-7sxioviw 63 5 Gil Gil NNP cord-332255-7sxioviw 63 6 and and CC cord-332255-7sxioviw 63 7 Romer Romer NNP cord-332255-7sxioviw 63 8 ( ( -LRB- cord-332255-7sxioviw 63 9 1980 1980 CD cord-332255-7sxioviw 63 10 ) ) -RRB- cord-332255-7sxioviw 63 11 , , , cord-332255-7sxioviw 63 12 Pearson Pearson NNP cord-332255-7sxioviw 63 13 and and CC cord-332255-7sxioviw 63 14 McNulty McNulty NNP cord-332255-7sxioviw 63 15 ( ( -LRB- cord-332255-7sxioviw 63 16 1979 1979 CD cord-332255-7sxioviw 63 17 ) ) -RRB- cord-332255-7sxioviw 63 18 and and CC cord-332255-7sxioviw 63 19 Saif Saif NNP cord-332255-7sxioviw 63 20 , , , cord-332255-7sxioviw 63 21 Theil Theil NNP cord-332255-7sxioviw 63 22 and and CC cord-332255-7sxioviw 63 23 Bohl Bohl NNP cord-332255-7sxioviw 63 24 ( ( -LRB- cord-332255-7sxioviw 63 25 1978 1978 CD cord-332255-7sxioviw 63 26 ) ) -RRB- cord-332255-7sxioviw 63 27 ) ) -RRB- cord-332255-7sxioviw 64 1 but but CC cord-332255-7sxioviw 64 2 detection detection NN cord-332255-7sxioviw 64 3 of of IN cord-332255-7sxioviw 64 4 virus virus NN cord-332255-7sxioviw 64 5 within within IN cord-332255-7sxioviw 64 6 goblet goblet NN cord-332255-7sxioviw 64 7 cells cell NNS cord-332255-7sxioviw 64 8 is be VBZ cord-332255-7sxioviw 64 9 a a DT cord-332255-7sxioviw 64 10 new new JJ cord-332255-7sxioviw 64 11 finding finding NN cord-332255-7sxioviw 64 12 . . . cord-332255-7sxioviw 65 1 4 4 LS cord-332255-7sxioviw 65 2 t t NN cord-332255-7sxioviw 65 3 low low JJ cord-332255-7sxioviw 65 4 magnification magnification NN cord-332255-7sxioviw 66 1 the the DT cord-332255-7sxioviw 66 2 infected infected JJ cord-332255-7sxioviw 66 3 cells cell NNS cord-332255-7sxioviw 66 4 were be VBD cord-332255-7sxioviw 66 5 visible visible JJ cord-332255-7sxioviw 66 6 , , , cord-332255-7sxioviw 66 7 with with IN cord-332255-7sxioviw 66 8 many many JJ cord-332255-7sxioviw 66 9 viral viral JJ cord-332255-7sxioviw 66 10 particles particle NNS cord-332255-7sxioviw 66 11 present present JJ cord-332255-7sxioviw 66 12 in in IN cord-332255-7sxioviw 66 13 the the DT cord-332255-7sxioviw 66 14 RER rer NN cord-332255-7sxioviw 66 15 and and CC cord-332255-7sxioviw 66 16 the the DT cord-332255-7sxioviw 66 17 apical apical JJ cord-332255-7sxioviw 66 18 cytoplasm cytoplasm NN cord-332255-7sxioviw 66 19 . . . cord-332255-7sxioviw 67 1 The the DT cord-332255-7sxioviw 67 2 least least JJS cord-332255-7sxioviw 67 3 severe severe JJ cord-332255-7sxioviw 67 4 and and CC cord-332255-7sxioviw 67 5 probably probably RB cord-332255-7sxioviw 67 6 the the DT cord-332255-7sxioviw 67 7 earliest early JJS cord-332255-7sxioviw 67 8 changes change NNS cord-332255-7sxioviw 67 9 consisted consist VBN cord-332255-7sxioviw 67 10 of of IN cord-332255-7sxioviw 67 11 shortening shortening NN cord-332255-7sxioviw 67 12 and and CC cord-332255-7sxioviw 67 13 loss loss NN cord-332255-7sxioviw 67 14 of of IN cord-332255-7sxioviw 67 15 the the DT cord-332255-7sxioviw 67 16 microvilli microvilli NN cord-332255-7sxioviw 67 17 . . . cord-332255-7sxioviw 68 1 At at IN cord-332255-7sxioviw 68 2 a a DT cord-332255-7sxioviw 68 3 more more RBR cord-332255-7sxioviw 68 4 advanced advanced JJ cord-332255-7sxioviw 68 5 stage stage NN cord-332255-7sxioviw 68 6 the the DT cord-332255-7sxioviw 68 7 infected infected JJ cord-332255-7sxioviw 68 8 cells cell NNS cord-332255-7sxioviw 68 9 were be VBD cord-332255-7sxioviw 68 10 rounded round VBN cord-332255-7sxioviw 68 11 , , , cord-332255-7sxioviw 68 12 had have VBD cord-332255-7sxioviw 68 13 large large JJ cord-332255-7sxioviw 68 14 lipid lipid NN cord-332255-7sxioviw 68 15 droplets droplet NNS cord-332255-7sxioviw 68 16 and and CC cord-332255-7sxioviw 68 17 an an DT cord-332255-7sxioviw 68 18 RER rer NN cord-332255-7sxioviw 68 19 distended distend VBN cord-332255-7sxioviw 68 20 with with IN cord-332255-7sxioviw 68 21 vacuoles vacuole NNS cord-332255-7sxioviw 68 22 . . . cord-332255-7sxioviw 69 1 Subsequently subsequently RB cord-332255-7sxioviw 69 2 , , , cord-332255-7sxioviw 69 3 most most JJS cord-332255-7sxioviw 69 4 of of IN cord-332255-7sxioviw 69 5 the the DT cord-332255-7sxioviw 69 6 absorptive absorptive JJ cord-332255-7sxioviw 69 7 cells cell NNS cord-332255-7sxioviw 69 8 appeared appear VBD cord-332255-7sxioviw 69 9 to to TO cord-332255-7sxioviw 69 10 be be VB cord-332255-7sxioviw 69 11 lost lose VBN cord-332255-7sxioviw 69 12 due due IN cord-332255-7sxioviw 69 13 to to IN cord-332255-7sxioviw 69 14 either either DT cord-332255-7sxioviw 69 15 cell cell NN cord-332255-7sxioviw 69 16 desquamation desquamation NN cord-332255-7sxioviw 69 17 or or CC cord-332255-7sxioviw 69 18 disruption disruption NN cord-332255-7sxioviw 69 19 . . . cord-332255-7sxioviw 70 1 Therefore therefore RB cord-332255-7sxioviw 70 2 , , , cord-332255-7sxioviw 70 3 the the DT cord-332255-7sxioviw 70 4 interaction interaction NN cord-332255-7sxioviw 70 5 of of IN cord-332255-7sxioviw 70 6 virus virus NN cord-332255-7sxioviw 70 7 and and CC cord-332255-7sxioviw 70 8 intestinal intestinal JJ cord-332255-7sxioviw 70 9 cells cell NNS cord-332255-7sxioviw 70 10 , , , cord-332255-7sxioviw 70 11 and and CC cord-332255-7sxioviw 70 12 the the DT cord-332255-7sxioviw 70 13 resulting result VBG cord-332255-7sxioviw 70 14 absorptive absorptive JJ cord-332255-7sxioviw 70 15 cell cell NN cord-332255-7sxioviw 70 16 degeneration degeneration NN cord-332255-7sxioviw 70 17 , , , cord-332255-7sxioviw 70 18 indicates indicate VBZ cord-332255-7sxioviw 70 19 that that IN cord-332255-7sxioviw 70 20 rotavirus rotavirus NN cord-332255-7sxioviw 70 21 is be VBZ cord-332255-7sxioviw 70 22 pathogenic pathogenic JJ cord-332255-7sxioviw 70 23 for for IN cord-332255-7sxioviw 70 24 the the DT cord-332255-7sxioviw 70 25 epithelial epithelial JJ cord-332255-7sxioviw 70 26 cells cell NNS cord-332255-7sxioviw 70 27 of of IN cord-332255-7sxioviw 70 28 the the DT cord-332255-7sxioviw 70 29 small small JJ cord-332255-7sxioviw 70 30 intestine intestine NN cord-332255-7sxioviw 70 31 . . . cord-332255-7sxioviw 71 1 These these DT cord-332255-7sxioviw 71 2 TEM tem NN cord-332255-7sxioviw 71 3 changes change NNS cord-332255-7sxioviw 71 4 correlated correlate VBN cord-332255-7sxioviw 71 5 well well RB cord-332255-7sxioviw 71 6 with with IN cord-332255-7sxioviw 71 7 those those DT cord-332255-7sxioviw 71 8 previously previously RB cord-332255-7sxioviw 71 9 found find VBN cord-332255-7sxioviw 71 10 by by IN cord-332255-7sxioviw 71 11 LM LM NNP cord-332255-7sxioviw 71 12 , , , cord-332255-7sxioviw 71 13 SEM SEM NNP cord-332255-7sxioviw 71 14 and and CC cord-332255-7sxioviw 71 15 FA FA NNP cord-332255-7sxioviw 71 16 examination examination NN cord-332255-7sxioviw 71 17 by by IN cord-332255-7sxioviw 71 18 Lecce Lecce NNP cord-332255-7sxioviw 71 19 , , , cord-332255-7sxioviw 71 20 King King NNP cord-332255-7sxioviw 71 21 and and CC cord-332255-7sxioviw 71 22 Mock Mock NNP cord-332255-7sxioviw 71 23 ( ( -LRB- cord-332255-7sxioviw 71 24 1976 1976 CD cord-332255-7sxioviw 71 25 ) ) -RRB- cord-332255-7sxioviw 71 26 , , , cord-332255-7sxioviw 71 27 McAdaragh McAdaragh NNP cord-332255-7sxioviw 71 28 et et NNP cord-332255-7sxioviw 71 29 al al NNP cord-332255-7sxioviw 71 30 . . . cord-332255-7sxioviw 72 1 ( ( -LRB- cord-332255-7sxioviw 72 2 1980 1980 CD cord-332255-7sxioviw 72 3 ) ) -RRB- cord-332255-7sxioviw 72 4 , , , cord-332255-7sxioviw 72 5 McNulty McNulty NNP cord-332255-7sxioviw 72 6 ( ( -LRB- cord-332255-7sxioviw 72 7 1977 1977 CD cord-332255-7sxioviw 72 8 ) ) -RRB- cord-332255-7sxioviw 72 9 , , , cord-332255-7sxioviw 72 10 Theil Theil NNP cord-332255-7sxioviw 72 11 et et NNP cord-332255-7sxioviw 72 12 al al NNP cord-332255-7sxioviw 72 13 . . . cord-332255-7sxioviw 73 1 ( ( -LRB- cord-332255-7sxioviw 73 2 1978 1978 CD cord-332255-7sxioviw 73 3 ) ) -RRB- cord-332255-7sxioviw 74 1 and and CC cord-332255-7sxioviw 74 2 Torres Torres NNP cord-332255-7sxioviw 74 3 - - HYPH cord-332255-7sxioviw 74 4 Medina Medina NNP cord-332255-7sxioviw 74 5 and and CC cord-332255-7sxioviw 74 6 Underdahl Underdahl NNP cord-332255-7sxioviw 74 7 ( ( -LRB- cord-332255-7sxioviw 74 8 1980 1980 CD cord-332255-7sxioviw 74 9 ) ) -RRB- cord-332255-7sxioviw 74 10 . . . cord-332255-7sxioviw 75 1 Concerning concern VBG cord-332255-7sxioviw 75 2 the the DT cord-332255-7sxioviw 75 3 entry entry NN cord-332255-7sxioviw 75 4 of of IN cord-332255-7sxioviw 75 5 the the DT cord-332255-7sxioviw 75 6 virus virus NN cord-332255-7sxioviw 75 7 into into IN cord-332255-7sxioviw 75 8 cells cell NNS cord-332255-7sxioviw 75 9 , , , cord-332255-7sxioviw 75 10 Pensaert Pensaert NNP cord-332255-7sxioviw 75 11 , , , cord-332255-7sxioviw 75 12 Haelterman Haelterman NNP cord-332255-7sxioviw 75 13 and and CC cord-332255-7sxioviw 75 14 Hinsman Hinsman NNP cord-332255-7sxioviw 75 15 ( ( -LRB- cord-332255-7sxioviw 75 16 1970 1970 CD cord-332255-7sxioviw 75 17 ) ) -RRB- cord-332255-7sxioviw 75 18 and and CC cord-332255-7sxioviw 75 19 Wagner Wagner NNP cord-332255-7sxioviw 75 20 , , , cord-332255-7sxioviw 75 21 Beamer Beamer NNP cord-332255-7sxioviw 75 22 and and CC cord-332255-7sxioviw 75 23 Ristic Ristic NNP cord-332255-7sxioviw 75 24 ( ( -LRB- cord-332255-7sxioviw 75 25 1973 1973 CD cord-332255-7sxioviw 75 26 ) ) -RRB- cord-332255-7sxioviw 75 27 reported report VBD cord-332255-7sxioviw 75 28 that that IN cord-332255-7sxioviw 75 29 transmissible transmissible JJ cord-332255-7sxioviw 75 30 gastroenteritis gastroenteritis NN cord-332255-7sxioviw 75 31 ( ( -LRB- cord-332255-7sxioviw 75 32 TGE TGE NNP cord-332255-7sxioviw 75 33 ) ) -RRB- cord-332255-7sxioviw 75 34 virions virion NNS cord-332255-7sxioviw 75 35 are be VBP cord-332255-7sxioviw 75 36 taken take VBN cord-332255-7sxioviw 75 37 up up RP cord-332255-7sxioviw 75 38 by by IN cord-332255-7sxioviw 75 39 pinocytosis pinocytosis NN cord-332255-7sxioviw 75 40 and and CC cord-332255-7sxioviw 75 41 then then RB cord-332255-7sxioviw 75 42 transported transport VBD cord-332255-7sxioviw 75 43 into into IN cord-332255-7sxioviw 75 44 the the DT cord-332255-7sxioviw 75 45 epithelial epithelial JJ cord-332255-7sxioviw 75 46 cytoplasm cytoplasm NN cord-332255-7sxioviw 75 47 . . . cord-332255-7sxioviw 76 1 Electron electron NN cord-332255-7sxioviw 76 2 micrographs micrograph NNS cord-332255-7sxioviw 76 3 of of IN cord-332255-7sxioviw 76 4 cells cell NNS cord-332255-7sxioviw 76 5 taken take VBN cord-332255-7sxioviw 76 6 12 12 CD cord-332255-7sxioviw 76 7 h h NN cord-332255-7sxioviw 76 8 after after IN cord-332255-7sxioviw 76 9 inoculation inoculation NN cord-332255-7sxioviw 76 10 with with IN cord-332255-7sxioviw 76 11 rotavirus rotavirus NN cord-332255-7sxioviw 76 12 revealed reveal VBN cord-332255-7sxioviw 76 13 viral viral JJ cord-332255-7sxioviw 76 14 particles particle NNS cord-332255-7sxioviw 76 15 between between IN cord-332255-7sxioviw 76 16 microvilli microvilli NN cord-332255-7sxioviw 76 17 and and CC cord-332255-7sxioviw 76 18 in in IN cord-332255-7sxioviw 76 19 the the DT cord-332255-7sxioviw 76 20 apical apical JJ cord-332255-7sxioviw 76 21 tips tip NNS cord-332255-7sxioviw 76 22 , , , cord-332255-7sxioviw 76 23 and and CC cord-332255-7sxioviw 76 24 vesicles vesicle NNS cord-332255-7sxioviw 76 25 in in IN cord-332255-7sxioviw 76 26 the the DT cord-332255-7sxioviw 76 27 terminal terminal NN cord-332255-7sxioviw 76 28 web web NN cord-332255-7sxioviw 76 29 areas area NNS cord-332255-7sxioviw 76 30 of of IN cord-332255-7sxioviw 76 31 some some DT cord-332255-7sxioviw 76 32 otherwise otherwise RB cord-332255-7sxioviw 76 33 apparently apparently RB cord-332255-7sxioviw 76 34 normal normal JJ cord-332255-7sxioviw 76 35 epithelial epithelial JJ cord-332255-7sxioviw 76 36 cells cell NNS cord-332255-7sxioviw 76 37 . . . cord-332255-7sxioviw 77 1 These these DT cord-332255-7sxioviw 77 2 findings finding NNS cord-332255-7sxioviw 77 3 resemble resemble VBP cord-332255-7sxioviw 77 4 those those DT cord-332255-7sxioviw 77 5 with with IN cord-332255-7sxioviw 77 6 TGE TGE NNP cord-332255-7sxioviw 77 7 virus virus NN cord-332255-7sxioviw 77 8 infection infection NN cord-332255-7sxioviw 77 9 and and CC cord-332255-7sxioviw 77 10 therefore therefore RB cord-332255-7sxioviw 77 11 they -PRON- PRP cord-332255-7sxioviw 77 12 strongly strongly RB cord-332255-7sxioviw 77 13 suggest suggest VBP cord-332255-7sxioviw 77 14 that that IN cord-332255-7sxioviw 77 15 porrinc porrinc NN cord-332255-7sxioviw 77 16 rotavirus rotavirus NN cord-332255-7sxioviw 77 17 is be VBZ cord-332255-7sxioviw 77 18 also also RB cord-332255-7sxioviw 77 19 taken take VBN cord-332255-7sxioviw 77 20 up up RP cord-332255-7sxioviw 77 21 by by IN cord-332255-7sxioviw 77 22 pinocytosis pinocytosis NNP cord-332255-7sxioviw 77 23 . . . cord-332255-7sxioviw 78 1 The the DT cord-332255-7sxioviw 78 2 present present JJ cord-332255-7sxioviw 78 3 EM EM NNP cord-332255-7sxioviw 78 4 observations observation NNS cord-332255-7sxioviw 78 5 have have VBP cord-332255-7sxioviw 78 6 provided provide VBN cord-332255-7sxioviw 78 7 additional additional JJ cord-332255-7sxioviw 78 8 information information NN cord-332255-7sxioviw 78 9 on on IN cord-332255-7sxioviw 78 10 the the DT cord-332255-7sxioviw 78 11 mode mode NN cord-332255-7sxioviw 78 12 of of IN cord-332255-7sxioviw 78 13 virus virus NN cord-332255-7sxioviw 78 14 release release NN cord-332255-7sxioviw 78 15 from from IN cord-332255-7sxioviw 78 16 host host NN cord-332255-7sxioviw 78 17 cells cell NNS cord-332255-7sxioviw 78 18 into into IN cord-332255-7sxioviw 78 19 the the DT cord-332255-7sxioviw 78 20 lumen lumen NN cord-332255-7sxioviw 78 21 . . . cord-332255-7sxioviw 79 1 There there EX cord-332255-7sxioviw 79 2 seem seem VBP cord-332255-7sxioviw 79 3 to to TO cord-332255-7sxioviw 79 4 be be VB cord-332255-7sxioviw 79 5 2 2 CD cord-332255-7sxioviw 79 6 processes process NNS cord-332255-7sxioviw 79 7 involved involve VBN cord-332255-7sxioviw 79 8 ; ; : cord-332255-7sxioviw 79 9 one one CD cord-332255-7sxioviw 79 10 is be VBZ cord-332255-7sxioviw 79 11 the the DT cord-332255-7sxioviw 79 12 desquamation desquamation NN cord-332255-7sxioviw 79 13 of of IN cord-332255-7sxioviw 79 14 the the DT cord-332255-7sxioviw 79 15 infected infected JJ cord-332255-7sxioviw 79 16 cells cell NNS cord-332255-7sxioviw 79 17 of of IN cord-332255-7sxioviw 79 18 the the DT cord-332255-7sxioviw 79 19 villous villous NN cord-332255-7sxioviw 79 20 . . . cord-332255-7sxioviw 79 21 . . . cord-332255-7sxioviw 80 1 cplthehal cplthehal NNP cord-332255-7sxioviw 80 2 lining line VBG cord-332255-7sxioviw 80 3 , , , cord-332255-7sxioviw 80 4 and and CC cord-332255-7sxioviw 80 5 the the DT cord-332255-7sxioviw 80 6 other other JJ cord-332255-7sxioviw 80 7 is be VBZ cord-332255-7sxioviw 80 8 the the DT cord-332255-7sxioviw 80 9 destruction destruction NN cord-332255-7sxioviw 80 10 of of IN cord-332255-7sxioviw 80 11 the the DT cord-332255-7sxioviw 80 12 luminal luminal JJ cord-332255-7sxioviw 80 13 plasma plasma NN cord-332255-7sxioviw 80 14 membrane membrane NN cord-332255-7sxioviw 80 15 , , , cord-332255-7sxioviw 80 16 with with IN cord-332255-7sxioviw 80 17 consequent consequent JJ cord-332255-7sxioviw 80 18 discharge discharge NN cord-332255-7sxioviw 80 19 of of IN cord-332255-7sxioviw 80 20 cytoplasmic cytoplasmic JJ cord-332255-7sxioviw 80 21 contents content NNS cord-332255-7sxioviw 80 22 . . . cord-332255-7sxioviw 81 1 These these DT cord-332255-7sxioviw 81 2 processes process NNS cord-332255-7sxioviw 81 3 are be VBP cord-332255-7sxioviw 81 4 commonly commonly RB cord-332255-7sxioviw 81 5 seen see VBN cord-332255-7sxioviw 81 6 in in IN cord-332255-7sxioviw 81 7 small small JJ cord-332255-7sxioviw 81 8 intestine intestine NN cord-332255-7sxioviw 81 9 infected infect VBN cord-332255-7sxioviw 81 10 with with IN cord-332255-7sxioviw 81 11 adenovirus adenovirus NN cord-332255-7sxioviw 81 12 ( ( -LRB- cord-332255-7sxioviw 81 13 Takeuchi Takeuchi NNP cord-332255-7sxioviw 81 14 _SP cord-332255-7sxioviw 81 15 and and CC cord-332255-7sxioviw 81 16 _SP cord-332255-7sxioviw 81 17 Hashimoto Hashimoto NNP cord-332255-7sxioviw 81 18 with with IN cord-332255-7sxioviw 81 19 other other JJ cord-332255-7sxioviw 81 20 enteric enteric JJ cord-332255-7sxioviw 81 21 viruses virus NNS cord-332255-7sxioviw 81 22 the the DT cord-332255-7sxioviw 81 23 same same JJ cord-332255-7sxioviw 81 24 release release NN cord-332255-7sxioviw 81 25 mechanisms mechanism NNS cord-332255-7sxioviw 81 26 from from IN cord-332255-7sxioviw 81 27 the the DT cord-332255-7sxioviw 81 28 epithelial epithelial JJ cord-332255-7sxioviw 81 29 cells cell NNS cord-332255-7sxioviw 81 30 into into IN cord-332255-7sxioviw 81 31 the the DT cord-332255-7sxioviw 81 32 lumen lumen NN cord-332255-7sxioviw 81 33 . . . cord-332255-7sxioviw 82 1 Five five CD cord-332255-7sxioviw 82 2 gnotobiotic gnotobiotic JJ cord-332255-7sxioviw 82 3 piglets piglet NNS cord-332255-7sxioviw 82 4 inoculated inoculate VBD cord-332255-7sxioviw 82 5 orally orally RB cord-332255-7sxioviw 82 6 with with IN cord-332255-7sxioviw 82 7 porcine porcine JJ cord-332255-7sxioviw 82 8 rotavirus rotavirus NN cord-332255-7sxioviw 82 9 developed develop VBD cord-332255-7sxioviw 82 10 an an DT cord-332255-7sxioviw 82 11 enteric enteric JJ cord-332255-7sxioviw 82 12 lesion lesion NN cord-332255-7sxioviw 82 13 . . . cord-332255-7sxioviw 83 1 Electron electron NN cord-332255-7sxioviw 83 2 microscopy microscopy NN cord-332255-7sxioviw 83 3 of of IN cord-332255-7sxioviw 83 4 the the DT cord-332255-7sxioviw 83 5 mucosal mucosal JJ cord-332255-7sxioviw 83 6 epithelium epithelium NN cord-332255-7sxioviw 83 7 12 12 CD cord-332255-7sxioviw 83 8 h h NN cord-332255-7sxioviw 83 9 after after IN cord-332255-7sxioviw 83 10 inoculation inoculation NN cord-332255-7sxioviw 83 11 showed show VBD cord-332255-7sxioviw 83 12 that that IN cord-332255-7sxioviw 83 13 the the DT cord-332255-7sxioviw 83 14 virus virus NN cord-332255-7sxioviw 83 15 penetrates penetrate VBZ cord-332255-7sxioviw 83 16 into into IN cord-332255-7sxioviw 83 17 the the DT cord-332255-7sxioviw 83 18 absorptive absorptive JJ cord-332255-7sxioviw 83 19 cells cell NNS cord-332255-7sxioviw 83 20 between between IN cord-332255-7sxioviw 83 21 microvilli microvilli NN cord-332255-7sxioviw 83 22 , , , cord-332255-7sxioviw 83 23 possibly possibly RB cord-332255-7sxioviw 83 24 by by IN cord-332255-7sxioviw 83 25 a a DT cord-332255-7sxioviw 83 26 pinocytic pinocytic JJ cord-332255-7sxioviw 83 27 mechanism mechanism NN cord-332255-7sxioviw 83 28 . . . cord-332255-7sxioviw 84 1 Afterwards afterwards RB cord-332255-7sxioviw 84 2 , , , cord-332255-7sxioviw 84 3 virus virus NN cord-332255-7sxioviw 84 4 particles particle NNS cord-332255-7sxioviw 84 5 were be VBD cord-332255-7sxioviw 84 6 most most RBS cord-332255-7sxioviw 84 7 often often RB cord-332255-7sxioviw 84 8 seen see VBN cord-332255-7sxioviw 84 9 within within IN cord-332255-7sxioviw 84 10 dilated dilated JJ cord-332255-7sxioviw 84 11 cisternae cisternae NN cord-332255-7sxioviw 84 12 of of IN cord-332255-7sxioviw 84 13 the the DT cord-332255-7sxioviw 84 14 rough rough JJ cord-332255-7sxioviw 84 15 endoplasmic endoplasmic NN cord-332255-7sxioviw 84 16 reticulum reticulum NN cord-332255-7sxioviw 84 17 ( ( -LRB- cord-332255-7sxioviw 84 18 RER RER NNP cord-332255-7sxioviw 84 19 ) ) -RRB- cord-332255-7sxioviw 84 20 . . . cord-332255-7sxioviw 85 1 These these DT cord-332255-7sxioviw 85 2 infected infected JJ cord-332255-7sxioviw 85 3 cells cell NNS cord-332255-7sxioviw 85 4 showed show VBD cord-332255-7sxioviw 85 5 a a DT cord-332255-7sxioviw 85 6 range range NN cord-332255-7sxioviw 85 7 of of IN cord-332255-7sxioviw 85 8 changes change NNS cord-332255-7sxioviw 85 9 , , , cord-332255-7sxioviw 85 10 such such JJ cord-332255-7sxioviw 85 11 as as IN cord-332255-7sxioviw 85 12 disruption disruption NN cord-332255-7sxioviw 85 13 of of IN cord-332255-7sxioviw 85 14 the the DT cord-332255-7sxioviw 85 15 microvilli microvilli NN cord-332255-7sxioviw 85 16 , , , cord-332255-7sxioviw 85 17 loss loss NN cord-332255-7sxioviw 85 18 of of IN cord-332255-7sxioviw 85 19 cytoplasmic cytoplasmic JJ cord-332255-7sxioviw 85 20 density density NN cord-332255-7sxioviw 85 21 and and CC cord-332255-7sxioviw 85 22 deposition deposition NN cord-332255-7sxioviw 85 23 of of IN cord-332255-7sxioviw 85 24 lipid lipid NN cord-332255-7sxioviw 85 25 droplets droplet NNS cord-332255-7sxioviw 85 26 . . . cord-332255-7sxioviw 86 1 Subsequently subsequently RB cord-332255-7sxioviw 86 2 , , , cord-332255-7sxioviw 86 3 most most JJS cord-332255-7sxioviw 86 4 of of IN cord-332255-7sxioviw 86 5 the the DT cord-332255-7sxioviw 86 6 epithelial epithelial JJ cord-332255-7sxioviw 86 7 cells cell NNS cord-332255-7sxioviw 86 8 were be VBD cord-332255-7sxioviw 86 9 desquamated desquamate VBN cord-332255-7sxioviw 86 10 from from IN cord-332255-7sxioviw 86 11 the the DT cord-332255-7sxioviw 86 12 villi villi NN cord-332255-7sxioviw 86 13 . . . cord-332255-7sxioviw 87 1 The the DT cord-332255-7sxioviw 87 2 interaction interaction NN cord-332255-7sxioviw 87 3 of of IN cord-332255-7sxioviw 87 4 virus virus NN cord-332255-7sxioviw 87 5 and and CC cord-332255-7sxioviw 87 6 intestinal intestinal JJ cord-332255-7sxioviw 87 7 cells cell NNS cord-332255-7sxioviw 87 8 thus thus RB cord-332255-7sxioviw 87 9 indicates indicate VBZ cord-332255-7sxioviw 87 10 that that IN cord-332255-7sxioviw 87 11 rotavirus rotavirus NN cord-332255-7sxioviw 87 12 is be VBZ cord-332255-7sxioviw 87 13 pathogenic pathogenic JJ cord-332255-7sxioviw 87 14 for for IN cord-332255-7sxioviw 87 15 the the DT cord-332255-7sxioviw 87 16 epithelial epithelial JJ cord-332255-7sxioviw 87 17 cells cell NNS cord-332255-7sxioviw 87 18 . . . cord-332255-7sxioviw 88 1 Intestinal intestinal JJ cord-332255-7sxioviw 88 2 changes change NNS cord-332255-7sxioviw 88 3 in in IN cord-332255-7sxioviw 88 4 gnotobiotic gnotobiotic JJ cord-332255-7sxioviw 88 5 piglets piglet NNS cord-332255-7sxioviw 88 6 experimentally experimentally RB cord-332255-7sxioviw 88 7 inoculated inoculate VBN cord-332255-7sxioviw 88 8 with with IN cord-332255-7sxioviw 88 9 porcine porcine JJ cord-332255-7sxioviw 88 10 rotavirus rotavirus JJ cord-332255-7sxioviw 88 11 Pathological pathological JJ cord-332255-7sxioviw 88 12 changes change NNS cord-332255-7sxioviw 88 13 in in IN cord-332255-7sxioviw 88 14 the the DT cord-332255-7sxioviw 88 15 small small JJ cord-332255-7sxioviw 88 16 intestine intestine NN cord-332255-7sxioviw 88 17 of of IN cord-332255-7sxioviw 88 18 neonatal neonatal JJ cord-332255-7sxioviw 88 19 pigs pig NNS cord-332255-7sxioviw 88 20 infected infect VBN cord-332255-7sxioviw 88 21 with with IN cord-332255-7sxioviw 88 22 a a DT cord-332255-7sxioviw 88 23 pig pig NN cord-332255-7sxioviw 88 24 reovirus reovirus NN cord-332255-7sxioviw 88 25 - - HYPH cord-332255-7sxioviw 88 26 like like JJ cord-332255-7sxioviw 88 27 agent agent NN cord-332255-7sxioviw 88 28 ( ( -LRB- cord-332255-7sxioviw 89 1 rotavirusj rotavirusj NNP cord-332255-7sxioviw 89 2 Transmissible transmissible JJ cord-332255-7sxioviw 89 3 gastroenteritis gastroenteritis NN cord-332255-7sxioviw 89 4 of of IN cord-332255-7sxioviw 89 5 swine swine NN cord-332255-7sxioviw 89 6 : : : cord-332255-7sxioviw 90 1 Virus virus NN cord-332255-7sxioviw 90 2 - - HYPH cord-332255-7sxioviw 90 3 intestinal intestinal JJ cord-332255-7sxioviw 90 4 cell cell NN cord-332255-7sxioviw 90 5 interactions interaction NNS cord-332255-7sxioviw 90 6 We -PRON- PRP cord-332255-7sxioviw 90 7 wish wish VBP cord-332255-7sxioviw 90 8 to to TO cord-332255-7sxioviw 90 9 thank thank VB cord-332255-7sxioviw 90 10 Dr Dr NNP cord-332255-7sxioviw 90 11 S. S. NNP cord-332255-7sxioviw 90 12 Konno Konno NNP cord-332255-7sxioviw 90 13 for for IN cord-332255-7sxioviw 90 14 suggestions suggestion NNS cord-332255-7sxioviw 90 15 , , , cord-332255-7sxioviw 90 16 and and CC cord-332255-7sxioviw 90 17 Mrs Mrs NNP cord-332255-7sxioviw 90 18 M. M. NNP cord-332255-7sxioviw 90 19 Osada Osada NNP cord-332255-7sxioviw 90 20 and and CC cord-332255-7sxioviw 90 21 Y. Y. NNP cord-332255-7sxioviw 90 22 Andow Andow NNP cord-332255-7sxioviw 90 23 for for IN cord-332255-7sxioviw 90 24 assistance assistance NN cord-332255-7sxioviw 90 25 with with IN cord-332255-7sxioviw 90 26 electron electron NN cord-332255-7sxioviw 90 27 microscopy microscopy NN cord-332255-7sxioviw 90 28 . . . cord-332255-7sxioviw 91 1 Journal Journal NNP cord-332255-7sxioviw 91 2 of of IN cord-332255-7sxioviw 91 3 General General NNP cord-332255-7sxioviw 91 4 Virology Virology NNP cord-332255-7sxioviw 91 5 , , , cord-332255-7sxioviw 91 6 37 37 CD cord-332255-7sxioviw 91 7 , , , cord-332255-7sxioviw 91 8 443 443 CD cord-332255-7sxioviw 91 9 - - SYM cord-332255-7sxioviw 91 10 451 451 CD cord-332255-7sxioviw 91 11 . . . cord-332255-7sxioviw 92 1 Esparza Esparza NNP cord-332255-7sxioviw 92 2 , , , cord-332255-7sxioviw 92 3 J. J. NNP cord-332255-7sxioviw 92 4 , , , cord-332255-7sxioviw 92 5 Gorziglia Gorziglia NNP cord-332255-7sxioviw 92 6 , , , cord-332255-7sxioviw 92 7 M. M. NNP cord-332255-7sxioviw 92 8 , , , cord-332255-7sxioviw 92 9 Gil Gil NNP cord-332255-7sxioviw 92 10 , , , cord-332255-7sxioviw 92 11 F. F. NNP cord-332255-7sxioviw 92 12 , , , cord-332255-7sxioviw 92 13 and and CC cord-332255-7sxioviw 92 14 Ramer Ramer NNP cord-332255-7sxioviw 92 15 , , , cord-332255-7sxioviw 92 16 H. H. NNP cord-332255-7sxioviw 92 17 ( ( -LRB- cord-332255-7sxioviw 92 18 1980 1980 CD cord-332255-7sxioviw 92 19 ) ) -RRB- cord-332255-7sxioviw 92 20 . . . cord-332255-7sxioviw 93 1 Multiplication multiplication NN cord-332255-7sxioviw 93 2 of of IN cord-332255-7sxioviw 93 3 human human JJ cord-332255-7sxioviw 93 4 rotavirus rotavirus NN cord-332255-7sxioviw 93 5 in in IN cord-332255-7sxioviw 93 6 culture culture NN cord-332255-7sxioviw 93 7 cells cell NNS cord-332255-7sxioviw 93 8 : : : cord-332255-7sxioviw 93 9 An an DT cord-332255-7sxioviw 93 10 electron electron NN cord-332255-7sxioviw 93 11 microscopic microscopic JJ cord-332255-7sxioviw 93 12 study study NN cord-332255-7sxioviw 93 13 . . . cord-332255-7sxioviw 94 1 Journal Journal NNP cord-332255-7sxioviw 94 2 of of IN cord-332255-7sxioviw 94 3 General General NNP cord-332255-7sxioviw 94 4 Virology Virology NNP cord-332255-7sxioviw 94 5 , , , cord-332255-7sxioviw 94 6 47 47 CD cord-332255-7sxioviw 94 7 , , , cord-332255-7sxioviw 94 8 46 46 CD cord-332255-7sxioviw 94 9 l-472 l-472 NN cord-332255-7sxioviw 94 10 . . . cord-332255-7sxioviw 95 1 Fukusho Fukusho NNP cord-332255-7sxioviw 95 2 , , , cord-332255-7sxioviw 95 3 A. A. NNP cord-332255-7sxioviw 95 4 , , , cord-332255-7sxioviw 95 5 Shimizu Shimizu NNP cord-332255-7sxioviw 95 6 , , , cord-332255-7sxioviw 95 7 Y. Y. NNP cord-332255-7sxioviw 95 8 , , , cord-332255-7sxioviw 95 9 and and CC cord-332255-7sxioviw 95 10 Ito Ito NNP cord-332255-7sxioviw 95 11 , , , cord-332255-7sxioviw 95 12 Y. Y. NNP cord-332255-7sxioviw 95 13 ( ( -LRB- cord-332255-7sxioviw 95 14 1981 1981 CD cord-332255-7sxioviw 95 15 ) ) -RRB- cord-332255-7sxioviw 95 16 _SP