id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314009-7t1bzc7f	Barclay, T.	Vaccine Adjuvant Nanotechnologies	2016-10-07		.txt	text/plain	7652	403	37	The modern definition of an adjuvant includes not only classical immune stimulators but also any aspects of particle size, shape, and surface chemistry that enhance vaccine immunogenicity. 71 A self-assembling nanofibrous hydrogel induced an antibody response when tested as a vaccine delivery platform, either alone or formulated with CpG adjuvant (TLR9 agonist) as a delivery system for recombinant hepatitis B surface antigen (HBsAg). 73, 74 For example, 165 nm-diameter liposomes assembled from cationic lipid, cationic polymer, and plasmid DNA were shown to target antigen to draining lymph nodes, resulting in enhanced DC activation and immunity. These particles were specifically designed to electrostatically interact with commercial hemagglutinin antigens to generate an influenza vaccine with enhanced immune responses compared with the hemagglutinin alone. Advax, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses	./cache/cord-314009-7t1bzc7f.txt	./txt/cord-314009-7t1bzc7f.txt