id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287708-0qvwjejv	Gera, Tamás	Application of pulsed laser ablation (PLA) for the size reduction of non-steroidal anti-inflammatory drugs (NSAIDs)	2020-09-25		.txt	text/plain	5386	354	58	We studied the application of pulsed laser ablation (PLA) for particle size reduction in non-steroidal anti-inflammatory drugs (NSAIDs). In this work, three NSAIDs (ibuprofen, meloxicam and niflumic acid) with different chemical structures but similar solubility, dissociation constant, particle size and crystallinity were selected as targets to study the effect of a high-energy pulsed laser beam on the chemical degradation and particle size distribution of the ablated drug particles. We studied the chemical composition and particle size distribution of the ablated particles, the optical absorption of the target drugs and made fast photography measurements too. Size distribution (measured by SMPS) of ibuprofen particles produced by laser ablation at 532 nm and 1064 nm wavelengths can be seen in Fig. 6 . conclusion PLA can be applied for the size reduction of poorly water-soluble NSAIDs. In the case of meloxicam, ibuprofen and niflumic acid, submicron to nanometer size particles can be produced by careful selection of the laser parameters, reducing the initial mean average sizes by orders of magnitude.	./cache/cord-287708-0qvwjejv.txt	./txt/cord-287708-0qvwjejv.txt