id	sid	tid	token	lemma	pos
cord-003302-vxk7uqlc	1	1	key	key	JJ
cord-003302-vxk7uqlc	1	2	:	:	:
cord-003302-vxk7uqlc	1	3	cord-003302-vxk7uqlc	cord-003302-vxk7uqlc	JJ
cord-003302-vxk7uqlc	1	4	authors	author	NNS
cord-003302-vxk7uqlc	1	5	:	:	:
cord-003302-vxk7uqlc	1	6	Fedson	Fedson	NNP
cord-003302-vxk7uqlc	1	7	,	,	,
cord-003302-vxk7uqlc	1	8	David	David	NNP
cord-003302-vxk7uqlc	1	9	S	S	NNP
cord-003302-vxk7uqlc	2	1	title	title	NN
cord-003302-vxk7uqlc	2	2	:	:	:
cord-003302-vxk7uqlc	2	3	Influenza	influenza	NN
cord-003302-vxk7uqlc	2	4	,	,	,
cord-003302-vxk7uqlc	2	5	evolution	evolution	NN
cord-003302-vxk7uqlc	2	6	,	,	,
cord-003302-vxk7uqlc	2	7	and	and	CC
cord-003302-vxk7uqlc	2	8	the	the	DT
cord-003302-vxk7uqlc	2	9	next	next	JJ
cord-003302-vxk7uqlc	2	10	pandemic	pandemic	NN
cord-003302-vxk7uqlc	2	11	date	date	NN
cord-003302-vxk7uqlc	2	12	:	:	:
cord-003302-vxk7uqlc	2	13	2018	2018	CD
cord-003302-vxk7uqlc	2	14	-	-	SYM
cord-003302-vxk7uqlc	2	15	10	10	CD
cord-003302-vxk7uqlc	2	16	-	-	HYPH
cord-003302-vxk7uqlc	2	17	03	03	CD
cord-003302-vxk7uqlc	2	18	journal	journal	NN
cord-003302-vxk7uqlc	2	19	:	:	:
cord-003302-vxk7uqlc	3	1	Evol	Evol	NNP
cord-003302-vxk7uqlc	3	2	Med	Med	NNP
cord-003302-vxk7uqlc	3	3	Public	Public	NNP
cord-003302-vxk7uqlc	3	4	Health	Health	NNP
cord-003302-vxk7uqlc	3	5	DOI	doi	NN
cord-003302-vxk7uqlc	3	6	:	:	:
cord-003302-vxk7uqlc	4	1	10.1093	10.1093	CD
cord-003302-vxk7uqlc	4	2	/	/	SYM
cord-003302-vxk7uqlc	4	3	emph	emph	NNP
cord-003302-vxk7uqlc	4	4	/	/	SYM
cord-003302-vxk7uqlc	4	5	eoy027	eoy027	NNP
cord-003302-vxk7uqlc	4	6	sha	sha	NNP
cord-003302-vxk7uqlc	4	7	:	:	:
cord-003302-vxk7uqlc	5	1	85cb4beac8d31f43c6756e2fc5af48784b9c8841	85cb4beac8d31f43c6756e2fc5af48784b9c8841	NNP
cord-003302-vxk7uqlc	5	2	doc_id	doc_id	CD
cord-003302-vxk7uqlc	5	3	:	:	:
cord-003302-vxk7uqlc	5	4	3302	3302	CD
cord-003302-vxk7uqlc	5	5	cord_uid	cord_uid	NNS
cord-003302-vxk7uqlc	5	6	:	:	:
cord-003302-vxk7uqlc	6	1	vxk7uqlc	vxk7uqlc	NNP
cord-003302-vxk7uqlc	6	2	Mortality	mortality	NN
cord-003302-vxk7uqlc	6	3	rates	rate	NNS
cord-003302-vxk7uqlc	6	4	in	in	IN
cord-003302-vxk7uqlc	6	5	influenza	influenza	NN
cord-003302-vxk7uqlc	6	6	appear	appear	VBP
cord-003302-vxk7uqlc	6	7	to	to	TO
cord-003302-vxk7uqlc	6	8	have	have	VB
cord-003302-vxk7uqlc	6	9	been	be	VBN
cord-003302-vxk7uqlc	6	10	shaped	shape	VBN
cord-003302-vxk7uqlc	6	11	by	by	IN
cord-003302-vxk7uqlc	6	12	evolution	evolution	NN
cord-003302-vxk7uqlc	6	13	.	.	.
cord-003302-vxk7uqlc	7	1	During	during	IN
cord-003302-vxk7uqlc	7	2	the	the	DT
cord-003302-vxk7uqlc	7	3	1918	1918	CD
cord-003302-vxk7uqlc	7	4	pandemic	pandemic	NN
cord-003302-vxk7uqlc	7	5	,	,	,
cord-003302-vxk7uqlc	7	6	mortality	mortality	NN
cord-003302-vxk7uqlc	7	7	rates	rate	NNS
cord-003302-vxk7uqlc	7	8	were	be	VBD
cord-003302-vxk7uqlc	7	9	lower	low	JJR
cord-003302-vxk7uqlc	7	10	in	in	IN
cord-003302-vxk7uqlc	7	11	children	child	NNS
cord-003302-vxk7uqlc	7	12	compared	compare	VBN
cord-003302-vxk7uqlc	7	13	with	with	IN
cord-003302-vxk7uqlc	7	14	adults	adult	NNS
cord-003302-vxk7uqlc	7	15	.	.	.
cord-003302-vxk7uqlc	8	1	This	this	DT
cord-003302-vxk7uqlc	8	2	mortality	mortality	NN
cord-003302-vxk7uqlc	8	3	difference	difference	NN
cord-003302-vxk7uqlc	8	4	occurs	occur	VBZ
cord-003302-vxk7uqlc	8	5	in	in	IN
cord-003302-vxk7uqlc	8	6	a	a	DT
cord-003302-vxk7uqlc	8	7	wide	wide	JJ
cord-003302-vxk7uqlc	8	8	variety	variety	NN
cord-003302-vxk7uqlc	8	9	of	of	IN
cord-003302-vxk7uqlc	8	10	infectious	infectious	JJ
cord-003302-vxk7uqlc	8	11	diseases	disease	NNS
cord-003302-vxk7uqlc	8	12	.	.	.
cord-003302-vxk7uqlc	9	1	It	-PRON-	PRP
cord-003302-vxk7uqlc	9	2	has	have	VBZ
cord-003302-vxk7uqlc	9	3	been	be	VBN
cord-003302-vxk7uqlc	9	4	replicated	replicate	VBN
cord-003302-vxk7uqlc	9	5	in	in	IN
cord-003302-vxk7uqlc	9	6	mice	mouse	NNS
cord-003302-vxk7uqlc	9	7	and	and	CC
cord-003302-vxk7uqlc	9	8	might	may	MD
cord-003302-vxk7uqlc	9	9	be	be	VB
cord-003302-vxk7uqlc	9	10	due	due	JJ
cord-003302-vxk7uqlc	9	11	to	to	IN
cord-003302-vxk7uqlc	9	12	greater	great	JJR
cord-003302-vxk7uqlc	9	13	tolerance	tolerance	NN
cord-003302-vxk7uqlc	9	14	of	of	IN
cord-003302-vxk7uqlc	9	15	infection	infection	NN
cord-003302-vxk7uqlc	9	16	,	,	,
cord-003302-vxk7uqlc	9	17	not	not	RB
cord-003302-vxk7uqlc	9	18	greater	great	JJR
cord-003302-vxk7uqlc	9	19	resistance	resistance	NN
cord-003302-vxk7uqlc	9	20	.	.	.
cord-003302-vxk7uqlc	10	1	Importantly	importantly	RB
cord-003302-vxk7uqlc	10	2	,	,	,
cord-003302-vxk7uqlc	10	3	combination	combination	NN
cord-003302-vxk7uqlc	10	4	treatment	treatment	NN
cord-003302-vxk7uqlc	10	5	with	with	IN
cord-003302-vxk7uqlc	10	6	inexpensive	inexpensive	JJ
cord-003302-vxk7uqlc	10	7	and	and	CC
cord-003302-vxk7uqlc	10	8	widely	widely	RB
cord-003302-vxk7uqlc	10	9	available	available	JJ
cord-003302-vxk7uqlc	10	10	generic	generic	JJ
cord-003302-vxk7uqlc	10	11	drugs	drug	NNS
cord-003302-vxk7uqlc	10	12	(	(	-LRB-
cord-003302-vxk7uqlc	10	13	e.g.	e.g.	IN
cord-003302-vxk7uqlc	10	14	statins	statin	NNS
cord-003302-vxk7uqlc	10	15	and	and	CC
cord-003302-vxk7uqlc	10	16	angiotensin	angiotensin	NN
cord-003302-vxk7uqlc	10	17	receptor	receptor	NN
cord-003302-vxk7uqlc	10	18	blockers	blocker	NNS
cord-003302-vxk7uqlc	10	19	)	)	-RRB-
cord-003302-vxk7uqlc	10	20	might	may	MD
cord-003302-vxk7uqlc	10	21	change	change	VB
cord-003302-vxk7uqlc	10	22	the	the	DT
cord-003302-vxk7uqlc	10	23	damaging	damaging	JJ
cord-003302-vxk7uqlc	10	24	host	host	NN
cord-003302-vxk7uqlc	10	25	response	response	NN
cord-003302-vxk7uqlc	10	26	in	in	IN
cord-003302-vxk7uqlc	10	27	adults	adult	NNS
cord-003302-vxk7uqlc	10	28	to	to	IN
cord-003302-vxk7uqlc	10	29	a	a	DT
cord-003302-vxk7uqlc	10	30	more	more	RBR
cord-003302-vxk7uqlc	10	31	tolerant	tolerant	JJ
cord-003302-vxk7uqlc	10	32	response	response	NN
cord-003302-vxk7uqlc	10	33	in	in	IN
cord-003302-vxk7uqlc	10	34	children	child	NNS
cord-003302-vxk7uqlc	10	35	.	.	.
cord-003302-vxk7uqlc	11	1	These	these	DT
cord-003302-vxk7uqlc	11	2	drugs	drug	NNS
cord-003302-vxk7uqlc	11	3	might	may	MD
cord-003302-vxk7uqlc	11	4	work	work	VB
cord-003302-vxk7uqlc	11	5	by	by	IN
cord-003302-vxk7uqlc	11	6	modifying	modify	VBG
cord-003302-vxk7uqlc	11	7	endothelial	endothelial	JJ
cord-003302-vxk7uqlc	11	8	dysfunction	dysfunction	NN
cord-003302-vxk7uqlc	11	9	,	,	,
cord-003302-vxk7uqlc	11	10	mitochondrial	mitochondrial	JJ
cord-003302-vxk7uqlc	11	11	biogenesis	biogenesis	NN
cord-003302-vxk7uqlc	11	12	and	and	CC
cord-003302-vxk7uqlc	11	13	immunometabolism	immunometabolism	NN
cord-003302-vxk7uqlc	11	14	.	.	.
cord-003302-vxk7uqlc	12	1	Treating	treat	VBG
cord-003302-vxk7uqlc	12	2	the	the	DT
cord-003302-vxk7uqlc	12	3	host	host	NN
cord-003302-vxk7uqlc	12	4	response	response	NN
cord-003302-vxk7uqlc	12	5	might	may	MD
cord-003302-vxk7uqlc	12	6	be	be	VB
cord-003302-vxk7uqlc	12	7	the	the	DT
cord-003302-vxk7uqlc	12	8	only	only	JJ
cord-003302-vxk7uqlc	12	9	practical	practical	JJ
cord-003302-vxk7uqlc	12	10	way	way	NN
cord-003302-vxk7uqlc	12	11	to	to	TO
cord-003302-vxk7uqlc	12	12	reduce	reduce	VB
cord-003302-vxk7uqlc	12	13	global	global	JJ
cord-003302-vxk7uqlc	12	14	mortality	mortality	NN
cord-003302-vxk7uqlc	12	15	during	during	IN
cord-003302-vxk7uqlc	12	16	the	the	DT
cord-003302-vxk7uqlc	12	17	next	next	JJ
cord-003302-vxk7uqlc	12	18	influenza	influenza	NN
cord-003302-vxk7uqlc	12	19	pandemic	pandemic	NN
cord-003302-vxk7uqlc	12	20	.	.	.
cord-003302-vxk7uqlc	13	1	It	-PRON-	PRP
cord-003302-vxk7uqlc	13	2	might	may	MD
cord-003302-vxk7uqlc	13	3	also	also	RB
cord-003302-vxk7uqlc	13	4	help	help	VB
cord-003302-vxk7uqlc	13	5	reduce	reduce	VB
cord-003302-vxk7uqlc	13	6	mortality	mortality	NN
cord-003302-vxk7uqlc	13	7	due	due	IN
cord-003302-vxk7uqlc	13	8	to	to	IN
cord-003302-vxk7uqlc	13	9	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	13	10	influenza	influenza	NN
cord-003302-vxk7uqlc	13	11	and	and	CC
cord-003302-vxk7uqlc	13	12	other	other	JJ
cord-003302-vxk7uqlc	13	13	forms	form	NNS
cord-003302-vxk7uqlc	13	14	of	of	IN
cord-003302-vxk7uqlc	13	15	acute	acute	JJ
cord-003302-vxk7uqlc	13	16	critical	critical	JJ
cord-003302-vxk7uqlc	13	17	illness	illness	NN
cord-003302-vxk7uqlc	13	18	.	.	.
cord-003302-vxk7uqlc	14	1	To	to	TO
cord-003302-vxk7uqlc	14	2	realize	realize	VB
cord-003302-vxk7uqlc	14	3	these	these	DT
cord-003302-vxk7uqlc	14	4	benefits	benefit	NNS
cord-003302-vxk7uqlc	14	5	,	,	,
cord-003302-vxk7uqlc	14	6	we	-PRON-	PRP
cord-003302-vxk7uqlc	14	7	need	need	VBP
cord-003302-vxk7uqlc	14	8	laboratory	laboratory	NN
cord-003302-vxk7uqlc	14	9	and	and	CC
cord-003302-vxk7uqlc	14	10	clinical	clinical	JJ
cord-003302-vxk7uqlc	14	11	studies	study	NNS
cord-003302-vxk7uqlc	14	12	of	of	IN
cord-003302-vxk7uqlc	14	13	host	host	NN
cord-003302-vxk7uqlc	14	14	response	response	NN
cord-003302-vxk7uqlc	14	15	treatment	treatment	NN
cord-003302-vxk7uqlc	14	16	before	before	RB
cord-003302-vxk7uqlc	14	17	and	and	CC
cord-003302-vxk7uqlc	14	18	after	after	IN
cord-003302-vxk7uqlc	14	19	puberty	puberty	NN
cord-003302-vxk7uqlc	14	20	.	.	.
cord-003302-vxk7uqlc	15	1	An	an	DT
cord-003302-vxk7uqlc	15	2	evolutionary	evolutionary	JJ
cord-003302-vxk7uqlc	15	3	perspective	perspective	NN
cord-003302-vxk7uqlc	15	4	in	in	IN
cord-003302-vxk7uqlc	15	5	public	public	JJ
cord-003302-vxk7uqlc	15	6	health	health	NN
cord-003302-vxk7uqlc	15	7	has	have	VBZ
cord-003302-vxk7uqlc	15	8	been	be	VBN
cord-003302-vxk7uqlc	15	9	important	important	JJ
cord-003302-vxk7uqlc	15	10	in	in	IN
cord-003302-vxk7uqlc	15	11	explaining	explain	VBG
cord-003302-vxk7uqlc	15	12	associations	association	NNS
cord-003302-vxk7uqlc	15	13	between	between	IN
cord-003302-vxk7uqlc	15	14	different	different	JJ
cord-003302-vxk7uqlc	15	15	human	human	JJ
cord-003302-vxk7uqlc	15	16	phenotypes	phenotype	NNS
cord-003302-vxk7uqlc	15	17	and	and	CC
cord-003302-vxk7uqlc	15	18	chronic	chronic	JJ
cord-003302-vxk7uqlc	15	19	diseases	disease	NNS
cord-003302-vxk7uqlc	15	20	[	[	-LRB-
cord-003302-vxk7uqlc	15	21	1	1	CD
cord-003302-vxk7uqlc	15	22	]	]	-RRB-
cord-003302-vxk7uqlc	15	23	.	.	.
cord-003302-vxk7uqlc	16	1	The	the	DT
cord-003302-vxk7uqlc	16	2	same	same	JJ
cord-003302-vxk7uqlc	16	3	perspective	perspective	NN
cord-003302-vxk7uqlc	16	4	might	may	MD
cord-003302-vxk7uqlc	16	5	help	help	VB
cord-003302-vxk7uqlc	16	6	us	-PRON-	PRP
cord-003302-vxk7uqlc	16	7	understand	understand	VB
cord-003302-vxk7uqlc	16	8	many	many	JJ
cord-003302-vxk7uqlc	16	9	forms	form	NNS
cord-003302-vxk7uqlc	16	10	of	of	IN
cord-003302-vxk7uqlc	16	11	acute	acute	JJ
cord-003302-vxk7uqlc	16	12	critical	critical	JJ
cord-003302-vxk7uqlc	16	13	illness	illness	NN
cord-003302-vxk7uqlc	16	14	.	.	.
cord-003302-vxk7uqlc	17	1	It	-PRON-	PRP
cord-003302-vxk7uqlc	17	2	might	may	MD
cord-003302-vxk7uqlc	17	3	also	also	RB
cord-003302-vxk7uqlc	17	4	suggest	suggest	VB
cord-003302-vxk7uqlc	17	5	better	well	JJR
cord-003302-vxk7uqlc	17	6	ways	way	NNS
cord-003302-vxk7uqlc	17	7	to	to	TO
cord-003302-vxk7uqlc	17	8	manage	manage	VB
cord-003302-vxk7uqlc	17	9	critically	critically	RB
cord-003302-vxk7uqlc	17	10	ill	ill	JJ
cord-003302-vxk7uqlc	17	11	patients	patient	NNS
cord-003302-vxk7uqlc	17	12	.	.	.
cord-003302-vxk7uqlc	18	1	Two	two	CD
cord-003302-vxk7uqlc	18	2	recent	recent	JJ
cord-003302-vxk7uqlc	18	3	studies	study	NNS
cord-003302-vxk7uqlc	18	4	of	of	IN
cord-003302-vxk7uqlc	18	5	influenza	influenza	NN
cord-003302-vxk7uqlc	18	6	virus	virus	NN
cord-003302-vxk7uqlc	18	7	infection	infection	NN
cord-003302-vxk7uqlc	18	8	and	and	CC
cord-003302-vxk7uqlc	18	9	endotoxemia	endotoxemia	NN
cord-003302-vxk7uqlc	18	10	in	in	IN
cord-003302-vxk7uqlc	18	11	mice	mouse	NNS
cord-003302-vxk7uqlc	18	12	have	have	VBP
cord-003302-vxk7uqlc	18	13	shown	show	VBN
cord-003302-vxk7uqlc	18	14	that	that	IN
cord-003302-vxk7uqlc	18	15	survival	survival	NN
cord-003302-vxk7uqlc	18	16	is	be	VBZ
cord-003302-vxk7uqlc	18	17	better	well	JJR
cord-003302-vxk7uqlc	18	18	before	before	IN
cord-003302-vxk7uqlc	18	19	puberty	puberty	NN
cord-003302-vxk7uqlc	18	20	than	than	IN
cord-003302-vxk7uqlc	18	21	after	after	IN
cord-003302-vxk7uqlc	18	22	puberty	puberty	NN
cord-003302-vxk7uqlc	18	23	.	.	.
cord-003302-vxk7uqlc	19	1	These	these	DT
cord-003302-vxk7uqlc	19	2	studies	study	NNS
cord-003302-vxk7uqlc	19	3	help	help	VBP
cord-003302-vxk7uqlc	19	4	explain	explain	VB
cord-003302-vxk7uqlc	19	5	the	the	DT
cord-003302-vxk7uqlc	19	6	lower	low	JJR
cord-003302-vxk7uqlc	19	7	mortality	mortality	NN
cord-003302-vxk7uqlc	19	8	in	in	IN
cord-003302-vxk7uqlc	19	9	children	child	NNS
cord-003302-vxk7uqlc	19	10	compared	compare	VBN
cord-003302-vxk7uqlc	19	11	with	with	IN
cord-003302-vxk7uqlc	19	12	adults	adult	NNS
cord-003302-vxk7uqlc	19	13	seen	see	VBN
cord-003302-vxk7uqlc	19	14	in	in	IN
cord-003302-vxk7uqlc	19	15	the	the	DT
cord-003302-vxk7uqlc	19	16	1918	1918	CD
cord-003302-vxk7uqlc	19	17	influenza	influenza	NN
cord-003302-vxk7uqlc	19	18	pandemic	pandemic	NN
cord-003302-vxk7uqlc	19	19	and	and	CC
cord-003302-vxk7uqlc	19	20	in	in	IN
cord-003302-vxk7uqlc	19	21	many	many	JJ
cord-003302-vxk7uqlc	19	22	other	other	JJ
cord-003302-vxk7uqlc	19	23	types	type	NNS
cord-003302-vxk7uqlc	19	24	of	of	IN
cord-003302-vxk7uqlc	19	25	acute	acute	JJ
cord-003302-vxk7uqlc	19	26	illness	illness	NN
cord-003302-vxk7uqlc	19	27	.	.	.
cord-003302-vxk7uqlc	20	1	This	this	DT
cord-003302-vxk7uqlc	20	2	difference	difference	NN
cord-003302-vxk7uqlc	20	3	is	be	VBZ
cord-003302-vxk7uqlc	20	4	probably	probably	RB
cord-003302-vxk7uqlc	20	5	the	the	DT
cord-003302-vxk7uqlc	20	6	heritage	heritage	NN
cord-003302-vxk7uqlc	20	7	of	of	IN
cord-003302-vxk7uqlc	20	8	human	human	JJ
cord-003302-vxk7uqlc	20	9	evolution	evolution	NN
cord-003302-vxk7uqlc	20	10	.	.	.
cord-003302-vxk7uqlc	21	1	Understanding	understand	VBG
cord-003302-vxk7uqlc	21	2	the	the	DT
cord-003302-vxk7uqlc	21	3	scientific	scientific	JJ
cord-003302-vxk7uqlc	21	4	basis	basis	NN
cord-003302-vxk7uqlc	21	5	for	for	IN
cord-003302-vxk7uqlc	21	6	this	this	DT
cord-003302-vxk7uqlc	21	7	difference	difference	NN
cord-003302-vxk7uqlc	21	8	suggests	suggest	VBZ
cord-003302-vxk7uqlc	21	9	an	an	DT
cord-003302-vxk7uqlc	21	10	alternative	alternative	JJ
cord-003302-vxk7uqlc	21	11	way	way	NN
cord-003302-vxk7uqlc	21	12	to	to	TO
cord-003302-vxk7uqlc	21	13	respond	respond	VB
cord-003302-vxk7uqlc	21	14	to	to	IN
cord-003302-vxk7uqlc	21	15	the	the	DT
cord-003302-vxk7uqlc	21	16	next	next	JJ
cord-003302-vxk7uqlc	21	17	pandemic	pandemic	NN
cord-003302-vxk7uqlc	21	18	.	.	.
cord-003302-vxk7uqlc	22	1	Instead	instead	RB
cord-003302-vxk7uqlc	22	2	of	of	IN
cord-003302-vxk7uqlc	22	3	relying	rely	VBG
cord-003302-vxk7uqlc	22	4	on	on	IN
cord-003302-vxk7uqlc	22	5	vaccination	vaccination	NN
cord-003302-vxk7uqlc	22	6	and	and	CC
cord-003302-vxk7uqlc	22	7	antiviral	antiviral	JJ
cord-003302-vxk7uqlc	22	8	treatment	treatment	NN
cord-003302-vxk7uqlc	22	9	,	,	,
cord-003302-vxk7uqlc	22	10	we	-PRON-	PRP
cord-003302-vxk7uqlc	22	11	might	may	MD
cord-003302-vxk7uqlc	22	12	be	be	VB
cord-003302-vxk7uqlc	22	13	able	able	JJ
cord-003302-vxk7uqlc	22	14	to	to	TO
cord-003302-vxk7uqlc	22	15	treat	treat	VB
cord-003302-vxk7uqlc	22	16	patients	patient	NNS
cord-003302-vxk7uqlc	22	17	with	with	IN
cord-003302-vxk7uqlc	22	18	inexpensive	inexpensive	JJ
cord-003302-vxk7uqlc	22	19	generic	generic	JJ
cord-003302-vxk7uqlc	22	20	drugs	drug	NNS
cord-003302-vxk7uqlc	22	21	that	that	WDT
cord-003302-vxk7uqlc	22	22	modify	modify	VBP
cord-003302-vxk7uqlc	22	23	the	the	DT
cord-003302-vxk7uqlc	22	24	host	host	NN
cord-003302-vxk7uqlc	22	25	response	response	NN
cord-003302-vxk7uqlc	22	26	to	to	IN
cord-003302-vxk7uqlc	22	27	acute	acute	JJ
cord-003302-vxk7uqlc	22	28	critical	critical	JJ
cord-003302-vxk7uqlc	22	29	illness	illness	NN
cord-003302-vxk7uqlc	22	30	.	.	.
cord-003302-vxk7uqlc	23	1	Unlike	unlike	IN
cord-003302-vxk7uqlc	23	2	pandemic	pandemic	NN
cord-003302-vxk7uqlc	23	3	vaccines	vaccine	NNS
cord-003302-vxk7uqlc	23	4	and	and	CC
cord-003302-vxk7uqlc	23	5	antiviral	antiviral	JJ
cord-003302-vxk7uqlc	23	6	treatments	treatment	NNS
cord-003302-vxk7uqlc	23	7	,	,	,
cord-003302-vxk7uqlc	23	8	these	these	DT
cord-003302-vxk7uqlc	23	9	drugs	drug	NNS
cord-003302-vxk7uqlc	23	10	will	will	MD
cord-003302-vxk7uqlc	23	11	be	be	VB
cord-003302-vxk7uqlc	23	12	available	available	JJ
cord-003302-vxk7uqlc	23	13	in	in	IN
cord-003302-vxk7uqlc	23	14	any	any	DT
cord-003302-vxk7uqlc	23	15	country	country	NN
cord-003302-vxk7uqlc	23	16	with	with	IN
cord-003302-vxk7uqlc	23	17	a	a	DT
cord-003302-vxk7uqlc	23	18	basic	basic	JJ
cord-003302-vxk7uqlc	23	19	healthcare	healthcare	NN
cord-003302-vxk7uqlc	23	20	system	system	NN
cord-003302-vxk7uqlc	23	21	.	.	.
cord-003302-vxk7uqlc	24	1	If	if	IN
cord-003302-vxk7uqlc	24	2	laboratory	laboratory	NN
cord-003302-vxk7uqlc	24	3	and	and	CC
cord-003302-vxk7uqlc	24	4	clinical	clinical	JJ
cord-003302-vxk7uqlc	24	5	research	research	NN
cord-003302-vxk7uqlc	24	6	convincingly	convincingly	RB
cord-003302-vxk7uqlc	24	7	demonstrates	demonstrate	VBZ
cord-003302-vxk7uqlc	24	8	this	this	DT
cord-003302-vxk7uqlc	24	9	approach	approach	NN
cord-003302-vxk7uqlc	24	10	works	work	VBZ
cord-003302-vxk7uqlc	24	11	,	,	,
cord-003302-vxk7uqlc	24	12	it	-PRON-	PRP
cord-003302-vxk7uqlc	24	13	would	would	MD
cord-003302-vxk7uqlc	24	14	benefit	benefit	VB
cord-003302-vxk7uqlc	24	15	people	people	NNS
cord-003302-vxk7uqlc	24	16	everywhere	everywhere	RB
cord-003302-vxk7uqlc	24	17	.	.	.
cord-003302-vxk7uqlc	25	1	This	this	DT
cord-003302-vxk7uqlc	25	2	idea	idea	NN
cord-003302-vxk7uqlc	25	3	has	have	VBZ
cord-003302-vxk7uqlc	25	4	been	be	VBN
cord-003302-vxk7uqlc	25	5	discussed	discuss	VBN
cord-003302-vxk7uqlc	25	6	several	several	JJ
cord-003302-vxk7uqlc	25	7	times	time	NNS
cord-003302-vxk7uqlc	25	8	in	in	IN
cord-003302-vxk7uqlc	25	9	the	the	DT
cord-003302-vxk7uqlc	25	10	past	past	JJ
cord-003302-vxk7uqlc	25	11	decade	decade	NN
cord-003302-vxk7uqlc	25	12	[	[	-LRB-
cord-003302-vxk7uqlc	25	13	2	2	CD
cord-003302-vxk7uqlc	25	14	]	]	-RRB-
cord-003302-vxk7uqlc	25	15	[	[	-LRB-
cord-003302-vxk7uqlc	25	16	3	3	CD
cord-003302-vxk7uqlc	25	17	]	]	-RRB-
cord-003302-vxk7uqlc	25	18	[	[	-LRB-
cord-003302-vxk7uqlc	25	19	4	4	CD
cord-003302-vxk7uqlc	25	20	]	]	-RRB-
cord-003302-vxk7uqlc	25	21	[	[	-LRB-
cord-003302-vxk7uqlc	25	22	5	5	CD
cord-003302-vxk7uqlc	25	23	]	]	-RRB-
cord-003302-vxk7uqlc	25	24	[	[	-LRB-
cord-003302-vxk7uqlc	25	25	6	6	CD
cord-003302-vxk7uqlc	25	26	]	]	-RRB-
cord-003302-vxk7uqlc	25	27	[	[	-LRB-
cord-003302-vxk7uqlc	25	28	7	7	CD
cord-003302-vxk7uqlc	25	29	]	]	-RRB-
cord-003302-vxk7uqlc	25	30	[	[	-LRB-
cord-003302-vxk7uqlc	25	31	8	8	CD
cord-003302-vxk7uqlc	25	32	]	]	-RRB-
cord-003302-vxk7uqlc	25	33	[	[	-LRB-
cord-003302-vxk7uqlc	25	34	9	9	CD
cord-003302-vxk7uqlc	25	35	]	]	-RRB-
cord-003302-vxk7uqlc	25	36	.	.	.
cord-003302-vxk7uqlc	26	1	The	the	DT
cord-003302-vxk7uqlc	26	2	1918	1918	CD
cord-003302-vxk7uqlc	26	3	influenza	influenza	NN
cord-003302-vxk7uqlc	26	4	pandemic	pandemic	NN
cord-003302-vxk7uqlc	26	5	is	be	VBZ
cord-003302-vxk7uqlc	26	6	remembered	remember	VBN
cord-003302-vxk7uqlc	26	7	because	because	IN
cord-003302-vxk7uqlc	26	8	it	-PRON-	PRP
cord-003302-vxk7uqlc	26	9	killed	kill	VBD
cord-003302-vxk7uqlc	26	10	as	as	RB
cord-003302-vxk7uqlc	26	11	many	many	JJ
cord-003302-vxk7uqlc	26	12	as	as	IN
cord-003302-vxk7uqlc	26	13	50	50	CD
cord-003302-vxk7uqlc	26	14	-	-	SYM
cord-003302-vxk7uqlc	26	15	100	100	CD
cord-003302-vxk7uqlc	26	16	million	million	CD
cord-003302-vxk7uqlc	26	17	people	people	NNS
cord-003302-vxk7uqlc	26	18	worldwide	worldwide	RB
cord-003302-vxk7uqlc	26	19	:	:	:
cord-003302-vxk7uqlc	26	20	an	an	DT
cord-003302-vxk7uqlc	26	21	estimated	estimate	VBN
cord-003302-vxk7uqlc	26	22	2.5	2.5	CD
cord-003302-vxk7uqlc	26	23	%	%	NN
cord-003302-vxk7uqlc	26	24	or	or	CC
cord-003302-vxk7uqlc	26	25	more	more	JJR
cord-003302-vxk7uqlc	26	26	of	of	IN
cord-003302-vxk7uqlc	26	27	the	the	DT
cord-003302-vxk7uqlc	26	28	global	global	JJ
cord-003302-vxk7uqlc	26	29	population	population	NN
cord-003302-vxk7uqlc	26	30	[	[	-LRB-
cord-003302-vxk7uqlc	26	31	9	9	CD
cord-003302-vxk7uqlc	26	32	]	]	-RRB-
cord-003302-vxk7uqlc	26	33	.	.	.
cord-003302-vxk7uqlc	27	1	Remarkably	remarkably	RB
cord-003302-vxk7uqlc	27	2	,	,	,
cord-003302-vxk7uqlc	27	3	the	the	DT
cord-003302-vxk7uqlc	27	4	mortality	mortality	NN
cord-003302-vxk7uqlc	27	5	rate	rate	NN
cord-003302-vxk7uqlc	27	6	was	be	VBD
cord-003302-vxk7uqlc	27	7	much	much	RB
cord-003302-vxk7uqlc	27	8	higher	high	JJR
cord-003302-vxk7uqlc	27	9	in	in	IN
cord-003302-vxk7uqlc	27	10	younger	young	JJR
cord-003302-vxk7uqlc	27	11	adults	adult	NNS
cord-003302-vxk7uqlc	27	12	than	than	IN
cord-003302-vxk7uqlc	27	13	it	-PRON-	PRP
cord-003302-vxk7uqlc	27	14	was	be	VBD
cord-003302-vxk7uqlc	27	15	in	in	IN
cord-003302-vxk7uqlc	27	16	children	child	NNS
cord-003302-vxk7uqlc	27	17	,	,	,
cord-003302-vxk7uqlc	27	18	giving	give	VBG
cord-003302-vxk7uqlc	27	19	rise	rise	NN
cord-003302-vxk7uqlc	27	20	to	to	IN
cord-003302-vxk7uqlc	27	21	the	the	DT
cord-003302-vxk7uqlc	27	22	familiar	familiar	JJ
cord-003302-vxk7uqlc	27	23	W	w	NN
cord-003302-vxk7uqlc	27	24	-	-	HYPH
cord-003302-vxk7uqlc	27	25	shaped	shape	VBN
cord-003302-vxk7uqlc	27	26	pandemic	pandemic	NN
cord-003302-vxk7uqlc	27	27	mortality	mortality	NN
cord-003302-vxk7uqlc	27	28	curve	curve	NN
cord-003302-vxk7uqlc	27	29	(	(	-LRB-
cord-003302-vxk7uqlc	27	30	Fig	Fig	NNP
cord-003302-vxk7uqlc	27	31	.	.	.
cord-003302-vxk7uqlc	27	32	1	1	CD
cord-003302-vxk7uqlc	27	33	)	)	-RRB-
cord-003302-vxk7uqlc	27	34	[	[	-LRB-
cord-003302-vxk7uqlc	27	35	6	6	CD
cord-003302-vxk7uqlc	27	36	,	,	,
cord-003302-vxk7uqlc	27	37	10	10	CD
cord-003302-vxk7uqlc	27	38	]	]	-RRB-
cord-003302-vxk7uqlc	27	39	.	.	.
cord-003302-vxk7uqlc	28	1	A	a	DT
cord-003302-vxk7uqlc	28	2	similar	similar	JJ
cord-003302-vxk7uqlc	28	3	mortality	mortality	NN
cord-003302-vxk7uqlc	28	4	pattern	pattern	NN
cord-003302-vxk7uqlc	28	5	has	have	VBZ
cord-003302-vxk7uqlc	28	6	not	not	RB
cord-003302-vxk7uqlc	28	7	been	be	VBN
cord-003302-vxk7uqlc	28	8	described	describe	VBN
cord-003302-vxk7uqlc	28	9	for	for	IN
cord-003302-vxk7uqlc	28	10	subsequent	subsequent	JJ
cord-003302-vxk7uqlc	28	11	pandemics	pandemic	NNS
cord-003302-vxk7uqlc	28	12	(	(	-LRB-
cord-003302-vxk7uqlc	28	13	1957	1957	CD
cord-003302-vxk7uqlc	28	14	,	,	,
cord-003302-vxk7uqlc	28	15	1968	1968	CD
cord-003302-vxk7uqlc	28	16	and	and	CC
cord-003302-vxk7uqlc	28	17	2009	2009	CD
cord-003302-vxk7uqlc	28	18	)	)	-RRB-
cord-003302-vxk7uqlc	28	19	.	.	.
cord-003302-vxk7uqlc	29	1	Some	some	DT
cord-003302-vxk7uqlc	29	2	investigators	investigator	NNS
cord-003302-vxk7uqlc	29	3	have	have	VBP
cord-003302-vxk7uqlc	29	4	attributed	attribute	VBN
cord-003302-vxk7uqlc	29	5	high	high	JJ
cord-003302-vxk7uqlc	29	6	pandemic	pandemic	NN
cord-003302-vxk7uqlc	29	7	mortality	mortality	NN
cord-003302-vxk7uqlc	29	8	in	in	IN
cord-003302-vxk7uqlc	29	9	young	young	JJ
cord-003302-vxk7uqlc	29	10	adults	adult	NNS
cord-003302-vxk7uqlc	29	11	to	to	IN
cord-003302-vxk7uqlc	29	12	secondary	secondary	JJ
cord-003302-vxk7uqlc	29	13	bacterial	bacterial	JJ
cord-003302-vxk7uqlc	29	14	pneumonia	pneumonia	NN
cord-003302-vxk7uqlc	29	15	[	[	-LRB-
cord-003302-vxk7uqlc	29	16	11	11	CD
cord-003302-vxk7uqlc	29	17	]	]	-RRB-
cord-003302-vxk7uqlc	29	18	.	.	.
cord-003302-vxk7uqlc	30	1	This	this	DT
cord-003302-vxk7uqlc	30	2	explanation	explanation	NN
cord-003302-vxk7uqlc	30	3	is	be	VBZ
cord-003302-vxk7uqlc	30	4	incomplete	incomplete	JJ
cord-003302-vxk7uqlc	30	5	and	and	CC
cord-003302-vxk7uqlc	30	6	unsatisfactory	unsatisfactory	JJ
cord-003302-vxk7uqlc	30	7	for	for	IN
cord-003302-vxk7uqlc	30	8	several	several	JJ
cord-003302-vxk7uqlc	30	9	reasons	reason	NNS
cord-003302-vxk7uqlc	30	10	.	.	.
cord-003302-vxk7uqlc	31	1	Children	child	NNS
cord-003302-vxk7uqlc	31	2	were	be	VBD
cord-003302-vxk7uqlc	31	3	infected	infect	VBN
cord-003302-vxk7uqlc	31	4	with	with	IN
cord-003302-vxk7uqlc	31	5	the	the	DT
cord-003302-vxk7uqlc	31	6	1918	1918	CD
cord-003302-vxk7uqlc	31	7	virus	virus	NN
cord-003302-vxk7uqlc	31	8	more	more	RBR
cord-003302-vxk7uqlc	31	9	frequently	frequently	RB
cord-003302-vxk7uqlc	31	10	than	than	IN
cord-003302-vxk7uqlc	31	11	adults	adult	NNS
cord-003302-vxk7uqlc	32	1	(	(	-LRB-
cord-003302-vxk7uqlc	32	2	Fig	Fig	NNP
cord-003302-vxk7uqlc	32	3	.	.	.
cord-003302-vxk7uqlc	33	1	1	1	LS
cord-003302-vxk7uqlc	33	2	)	)	-RRB-
cord-003302-vxk7uqlc	34	1	and	and	CC
cord-003302-vxk7uqlc	34	2	they	-PRON-	PRP
cord-003302-vxk7uqlc	34	3	were	be	VBD
cord-003302-vxk7uqlc	34	4	almost	almost	RB
cord-003302-vxk7uqlc	34	5	certainly	certainly	RB
cord-003302-vxk7uqlc	34	6	colonized	colonize	VBN
cord-003302-vxk7uqlc	34	7	with	with	IN
cord-003302-vxk7uqlc	34	8	the	the	DT
cord-003302-vxk7uqlc	34	9	same	same	JJ
cord-003302-vxk7uqlc	34	10	bacteria	bacteria	NNS
cord-003302-vxk7uqlc	34	11	that	that	WDT
cord-003302-vxk7uqlc	34	12	were	be	VBD
cord-003302-vxk7uqlc	34	13	associated	associate	VBN
cord-003302-vxk7uqlc	34	14	with	with	IN
cord-003302-vxk7uqlc	34	15	bacterial	bacterial	JJ
cord-003302-vxk7uqlc	34	16	pneumonia	pneumonia	NN
cord-003302-vxk7uqlc	34	17	in	in	IN
cord-003302-vxk7uqlc	34	18	adults	adult	NNS
cord-003302-vxk7uqlc	34	19	,	,	,
cord-003302-vxk7uqlc	34	20	yet	yet	RB
cord-003302-vxk7uqlc	35	1	their	-PRON-	PRP$
cord-003302-vxk7uqlc	35	2	pneumonia	pneumonia	NN
cord-003302-vxk7uqlc	35	3	mortality	mortality	NN
cord-003302-vxk7uqlc	35	4	rates	rate	NNS
cord-003302-vxk7uqlc	35	5	were	be	VBD
cord-003302-vxk7uqlc	35	6	much	much	RB
cord-003302-vxk7uqlc	35	7	lower	low	JJR
cord-003302-vxk7uqlc	35	8	[	[	-LRB-
cord-003302-vxk7uqlc	35	9	6	6	CD
cord-003302-vxk7uqlc	35	10	,	,	,
cord-003302-vxk7uqlc	35	11	12	12	CD
cord-003302-vxk7uqlc	35	12	]	]	-RRB-
cord-003302-vxk7uqlc	35	13	.	.	.
cord-003302-vxk7uqlc	36	1	More	more	RBR
cord-003302-vxk7uqlc	36	2	important	important	JJ
cord-003302-vxk7uqlc	36	3	,	,	,
cord-003302-vxk7uqlc	36	4	lower	low	JJR
cord-003302-vxk7uqlc	36	5	mortality	mortality	NN
cord-003302-vxk7uqlc	36	6	among	among	IN
cord-003302-vxk7uqlc	36	7	children	child	NNS
cord-003302-vxk7uqlc	36	8	compared	compare	VBN
cord-003302-vxk7uqlc	36	9	with	with	IN
cord-003302-vxk7uqlc	36	10	adults	adult	NNS
cord-003302-vxk7uqlc	36	11	was	be	VBD
cord-003302-vxk7uqlc	36	12	not	not	RB
cord-003302-vxk7uqlc	36	13	unique	unique	JJ
cord-003302-vxk7uqlc	36	14	to	to	IN
cord-003302-vxk7uqlc	36	15	the	the	DT
cord-003302-vxk7uqlc	36	16	1918	1918	CD
cord-003302-vxk7uqlc	36	17	pandemic	pandemic	NN
cord-003302-vxk7uqlc	36	18	.	.	.
cord-003302-vxk7uqlc	37	1	Children	child	NNS
cord-003302-vxk7uqlc	37	2	have	have	VBP
cord-003302-vxk7uqlc	37	3	lower	low	JJR
cord-003302-vxk7uqlc	37	4	mortality	mortality	NN
cord-003302-vxk7uqlc	37	5	than	than	IN
cord-003302-vxk7uqlc	37	6	adults	adult	NNS
cord-003302-vxk7uqlc	37	7	due	due	JJ
cord-003302-vxk7uqlc	37	8	to	to	IN
cord-003302-vxk7uqlc	37	9	infections	infection	NNS
cord-003302-vxk7uqlc	37	10	caused	cause	VBN
cord-003302-vxk7uqlc	37	11	by	by	IN
cord-003302-vxk7uqlc	37	12	many	many	JJ
cord-003302-vxk7uqlc	37	13	bacteria	bacteria	NNS
cord-003302-vxk7uqlc	37	14	(	(	-LRB-
cord-003302-vxk7uqlc	37	15	e.g.	e.g.	RB
cord-003302-vxk7uqlc	37	16	Group	Group	NNP
cord-003302-vxk7uqlc	37	17	A	A	NNP
cord-003302-vxk7uqlc	37	18	Streptococcus	Streptococcus	NNP
cord-003302-vxk7uqlc	37	19	,	,	,
cord-003302-vxk7uqlc	37	20	S.	S.	NNP
cord-003302-vxk7uqlc	37	21	pneumoniae	pneumoniae	NN
cord-003302-vxk7uqlc	37	22	,	,	,
cord-003302-vxk7uqlc	37	23	S.	S.	NNP
cord-003302-vxk7uqlc	37	24	aureus	aureus	NN
cord-003302-vxk7uqlc	37	25	and	and	CC
cord-003302-vxk7uqlc	37	26	M.	M.	NNP
cord-003302-vxk7uqlc	37	27	tuberculosis	tuberculosis	NN
cord-003302-vxk7uqlc	37	28	)	)	-RRB-
cord-003302-vxk7uqlc	37	29	and	and	CC
cord-003302-vxk7uqlc	37	30	viruses	virus	NNS
cord-003302-vxk7uqlc	37	31	(	(	-LRB-
cord-003302-vxk7uqlc	37	32	e.g.	e.g.	RB
cord-003302-vxk7uqlc	37	33	mumps	mumps	NN
cord-003302-vxk7uqlc	37	34	,	,	,
cord-003302-vxk7uqlc	37	35	varicella	varicella	NN
cord-003302-vxk7uqlc	37	36	,	,	,
cord-003302-vxk7uqlc	37	37	poliomyelitis	poliomyelitis	NN
cord-003302-vxk7uqlc	37	38	,	,	,
cord-003302-vxk7uqlc	37	39	Epstein	Epstein	NNP
cord-003302-vxk7uqlc	37	40	Barr	Barr	NNP
cord-003302-vxk7uqlc	37	41	virus	virus	NN
cord-003302-vxk7uqlc	37	42	,	,	,
cord-003302-vxk7uqlc	37	43	hepatitis	hepatitis	NN
cord-003302-vxk7uqlc	37	44	E	e	NN
cord-003302-vxk7uqlc	37	45	,	,	,
cord-003302-vxk7uqlc	37	46	yellow	yellow	JJ
cord-003302-vxk7uqlc	37	47	fever	fever	NN
cord-003302-vxk7uqlc	37	48	,	,	,
cord-003302-vxk7uqlc	37	49	SARS	SARS	NNP
cord-003302-vxk7uqlc	37	50	and	and	CC
cord-003302-vxk7uqlc	37	51	smallpox	smallpox	NN
cord-003302-vxk7uqlc	37	52	)	)	-RRB-
cord-003302-vxk7uqlc	37	53	.	.	.
cord-003302-vxk7uqlc	38	1	Similar	similar	JJ
cord-003302-vxk7uqlc	38	2	mortality	mortality	NN
cord-003302-vxk7uqlc	38	3	differences	difference	NNS
cord-003302-vxk7uqlc	38	4	have	have	VBP
cord-003302-vxk7uqlc	38	5	been	be	VBN
cord-003302-vxk7uqlc	38	6	seen	see	VBN
cord-003302-vxk7uqlc	38	7	in	in	IN
cord-003302-vxk7uqlc	38	8	several	several	JJ
cord-003302-vxk7uqlc	38	9	other	other	JJ
cord-003302-vxk7uqlc	38	10	conditions	condition	NNS
cord-003302-vxk7uqlc	38	11	(	(	-LRB-
cord-003302-vxk7uqlc	38	12	e.g.	e.g.	RB
cord-003302-vxk7uqlc	38	13	disseminated	disseminate	VBN
cord-003302-vxk7uqlc	38	14	C.	C.	NNP
cord-003302-vxk7uqlc	38	15	albicans	albican	NNS
cord-003302-vxk7uqlc	38	16	infection	infection	NN
cord-003302-vxk7uqlc	38	17	,	,	,
cord-003302-vxk7uqlc	38	18	acute	acute	JJ
cord-003302-vxk7uqlc	38	19	lung	lung	NN
cord-003302-vxk7uqlc	38	20	injury	injury	NN
cord-003302-vxk7uqlc	38	21	accompanying	accompany	VBG
cord-003302-vxk7uqlc	38	22	severe	severe	JJ
cord-003302-vxk7uqlc	38	23	malaria	malaria	NN
cord-003302-vxk7uqlc	38	24	,	,	,
cord-003302-vxk7uqlc	38	25	sickle	sickle	NN
cord-003302-vxk7uqlc	38	26	cell	cell	NN
cord-003302-vxk7uqlc	38	27	chest	chest	NN
cord-003302-vxk7uqlc	38	28	syndrome	syndrome	NN
cord-003302-vxk7uqlc	38	29	,	,	,
cord-003302-vxk7uqlc	38	30	multi	multi	JJ
cord-003302-vxk7uqlc	38	31	-	-	JJ
cord-003302-vxk7uqlc	38	32	organ	organ	JJ
cord-003302-vxk7uqlc	38	33	failure	failure	NN
cord-003302-vxk7uqlc	38	34	following	follow	VBG
cord-003302-vxk7uqlc	38	35	severe	severe	JJ
cord-003302-vxk7uqlc	38	36	trauma	trauma	NN
cord-003302-vxk7uqlc	38	37	,	,	,
cord-003302-vxk7uqlc	38	38	severe	severe	JJ
cord-003302-vxk7uqlc	38	39	burn	burn	NN
cord-003302-vxk7uqlc	38	40	injury	injury	NN
cord-003302-vxk7uqlc	38	41	and	and	CC
cord-003302-vxk7uqlc	38	42	febrile	febrile	JJ
cord-003302-vxk7uqlc	38	43	neutropenia	neutropenia	NN
cord-003302-vxk7uqlc	38	44	)	)	-RRB-
cord-003302-vxk7uqlc	39	1	[	[	-LRB-
cord-003302-vxk7uqlc	39	2	6	6	CD
cord-003302-vxk7uqlc	39	3	,	,	,
cord-003302-vxk7uqlc	39	4	10	10	CD
cord-003302-vxk7uqlc	39	5	]	]	-RRB-
cord-003302-vxk7uqlc	39	6	.	.	.
cord-003302-vxk7uqlc	40	1	In	in	IN
cord-003302-vxk7uqlc	40	2	short	short	JJ
cord-003302-vxk7uqlc	40	3	,	,	,
cord-003302-vxk7uqlc	40	4	lower	low	JJR
cord-003302-vxk7uqlc	40	5	mortality	mortality	NN
cord-003302-vxk7uqlc	40	6	rates	rate	NNS
cord-003302-vxk7uqlc	40	7	among	among	IN
cord-003302-vxk7uqlc	40	8	children	child	NNS
cord-003302-vxk7uqlc	40	9	were	be	VBD
cord-003302-vxk7uqlc	40	10	not	not	RB
cord-003302-vxk7uqlc	40	11	unique	unique	JJ
cord-003302-vxk7uqlc	40	12	to	to	IN
cord-003302-vxk7uqlc	40	13	the	the	DT
cord-003302-vxk7uqlc	40	14	1918	1918	CD
cord-003302-vxk7uqlc	40	15	pandemic	pandemic	NN
cord-003302-vxk7uqlc	40	16	.	.	.
cord-003302-vxk7uqlc	41	1	Most	Most	JJS
cord-003302-vxk7uqlc	41	2	influenza	influenza	NN
cord-003302-vxk7uqlc	41	3	scientists	scientist	NNS
cord-003302-vxk7uqlc	41	4	have	have	VBP
cord-003302-vxk7uqlc	41	5	sought	seek	VBN
cord-003302-vxk7uqlc	41	6	to	to	TO
cord-003302-vxk7uqlc	41	7	explain	explain	VB
cord-003302-vxk7uqlc	41	8	the	the	DT
cord-003302-vxk7uqlc	41	9	1918	1918	CD
cord-003302-vxk7uqlc	41	10	mortality	mortality	NN
cord-003302-vxk7uqlc	41	11	difference	difference	NN
cord-003302-vxk7uqlc	41	12	by	by	IN
cord-003302-vxk7uqlc	41	13	studying	study	VBG
cord-003302-vxk7uqlc	41	14	the	the	DT
cord-003302-vxk7uqlc	41	15	virus	virus	NN
cord-003302-vxk7uqlc	41	16	.	.	.
cord-003302-vxk7uqlc	42	1	Numerous	numerous	JJ
cord-003302-vxk7uqlc	42	2	reports	report	NNS
cord-003302-vxk7uqlc	42	3	have	have	VBP
cord-003302-vxk7uqlc	42	4	shown	show	VBN
cord-003302-vxk7uqlc	42	5	that	that	IN
cord-003302-vxk7uqlc	42	6	the	the	DT
cord-003302-vxk7uqlc	42	7	virulence	virulence	NN
cord-003302-vxk7uqlc	42	8	of	of	IN
cord-003302-vxk7uqlc	42	9	individual	individual	JJ
cord-003302-vxk7uqlc	42	10	influenza	influenza	NN
cord-003302-vxk7uqlc	42	11	viruses	virus	NNS
cord-003302-vxk7uqlc	42	12	differs	differ	VBZ
cord-003302-vxk7uqlc	42	13	markedly	markedly	RB
cord-003302-vxk7uqlc	42	14	in	in	IN
cord-003302-vxk7uqlc	42	15	laboratory	laboratory	NN
cord-003302-vxk7uqlc	42	16	models	model	NNS
cord-003302-vxk7uqlc	42	17	of	of	IN
cord-003302-vxk7uqlc	42	18	infection	infection	NN
cord-003302-vxk7uqlc	42	19	.	.	.
cord-003302-vxk7uqlc	43	1	For	for	IN
cord-003302-vxk7uqlc	43	2	example	example	NN
cord-003302-vxk7uqlc	43	3	,	,	,
cord-003302-vxk7uqlc	43	4	influenza	influenza	NN
cord-003302-vxk7uqlc	43	5	A	a	NN
cord-003302-vxk7uqlc	43	6	(	(	-LRB-
cord-003302-vxk7uqlc	43	7	H3N2	H3N2	NNP
cord-003302-vxk7uqlc	43	8	)	)	-RRB-
cord-003302-vxk7uqlc	43	9	viruses	virus	NNS
cord-003302-vxk7uqlc	43	10	are	be	VBP
cord-003302-vxk7uqlc	43	11	generally	generally	RB
cord-003302-vxk7uqlc	43	12	more	more	RBR
cord-003302-vxk7uqlc	43	13	virulent	virulent	JJ
cord-003302-vxk7uqlc	43	14	than	than	IN
cord-003302-vxk7uqlc	43	15	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	43	16	viruses	virus	NNS
cord-003302-vxk7uqlc	43	17	,	,	,
cord-003302-vxk7uqlc	43	18	and	and	CC
cord-003302-vxk7uqlc	43	19	the	the	DT
cord-003302-vxk7uqlc	43	20	1918	1918	CD
cord-003302-vxk7uqlc	43	21	virus	virus	NN
cord-003302-vxk7uqlc	43	22	(	(	-LRB-
cord-003302-vxk7uqlc	43	23	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	43	24	)	)	-RRB-
cord-003302-vxk7uqlc	43	25	was	be	VBD
cord-003302-vxk7uqlc	43	26	more	more	RBR
cord-003302-vxk7uqlc	43	27	virulent	virulent	JJ
cord-003302-vxk7uqlc	43	28	than	than	IN
cord-003302-vxk7uqlc	43	29	the	the	DT
cord-003302-vxk7uqlc	43	30	ordinary	ordinary	JJ
cord-003302-vxk7uqlc	43	31	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	43	32	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	43	33	influenza	influenza	NN
cord-003302-vxk7uqlc	43	34	viruses	virus	NNS
cord-003302-vxk7uqlc	43	35	seen	see	VBN
cord-003302-vxk7uqlc	43	36	today	today	NN
cord-003302-vxk7uqlc	43	37	.	.	.
cord-003302-vxk7uqlc	44	1	Antigenic	antigenic	JJ
cord-003302-vxk7uqlc	44	2	changes	change	NNS
cord-003302-vxk7uqlc	44	3	in	in	IN
cord-003302-vxk7uqlc	44	4	human	human	JJ
cord-003302-vxk7uqlc	44	5	influenza	influenza	NN
cord-003302-vxk7uqlc	44	6	viruses	virus	NNS
cord-003302-vxk7uqlc	44	7	are	be	VBP
cord-003302-vxk7uqlc	44	8	frequently	frequently	RB
cord-003302-vxk7uqlc	44	9	reported	report	VBN
cord-003302-vxk7uqlc	44	10	over	over	IN
cord-003302-vxk7uqlc	44	11	the	the	DT
cord-003302-vxk7uqlc	44	12	course	course	NN
cord-003302-vxk7uqlc	44	13	of	of	IN
cord-003302-vxk7uqlc	44	14	a	a	DT
cord-003302-vxk7uqlc	44	15	single	single	JJ
cord-003302-vxk7uqlc	44	16	influenza	influenza	NN
cord-003302-vxk7uqlc	44	17	season	season	NN
cord-003302-vxk7uqlc	44	18	[	[	-LRB-
cord-003302-vxk7uqlc	44	19	13	13	CD
cord-003302-vxk7uqlc	44	20	]	]	-RRB-
cord-003302-vxk7uqlc	44	21	,	,	,
cord-003302-vxk7uqlc	44	22	and	and	CC
cord-003302-vxk7uqlc	44	23	in	in	IN
cord-003302-vxk7uqlc	44	24	1918	1918	CD
cord-003302-vxk7uqlc	44	25	the	the	DT
cord-003302-vxk7uqlc	44	26	mortality	mortality	NN
cord-003302-vxk7uqlc	44	27	impact	impact	NN
cord-003302-vxk7uqlc	44	28	of	of	IN
cord-003302-vxk7uqlc	44	29	the	the	DT
cord-003302-vxk7uqlc	44	30	second	second	JJ
cord-003302-vxk7uqlc	44	31	pandemic	pandemic	NN
cord-003302-vxk7uqlc	44	32	wave	wave	NN
cord-003302-vxk7uqlc	44	33	in	in	IN
cord-003302-vxk7uqlc	44	34	the	the	DT
cord-003302-vxk7uqlc	44	35	fall	fall	NN
cord-003302-vxk7uqlc	44	36	was	be	VBD
cord-003302-vxk7uqlc	44	37	much	much	RB
cord-003302-vxk7uqlc	44	38	greater	great	JJR
cord-003302-vxk7uqlc	44	39	than	than	IN
cord-003302-vxk7uqlc	44	40	it	-PRON-	PRP
cord-003302-vxk7uqlc	44	41	was	be	VBD
cord-003302-vxk7uqlc	44	42	during	during	IN
cord-003302-vxk7uqlc	44	43	the	the	DT
cord-003302-vxk7uqlc	44	44	first	first	JJ
cord-003302-vxk7uqlc	44	45	wave	wave	NN
cord-003302-vxk7uqlc	44	46	the	the	DT
cord-003302-vxk7uqlc	44	47	preceding	precede	VBG
cord-003302-vxk7uqlc	44	48	spring	spring	NN
cord-003302-vxk7uqlc	44	49	[	[	-LRB-
cord-003302-vxk7uqlc	44	50	10	10	CD
cord-003302-vxk7uqlc	44	51	]	]	-RRB-
cord-003302-vxk7uqlc	44	52	.	.	.
cord-003302-vxk7uqlc	45	1	Several	several	JJ
cord-003302-vxk7uqlc	45	2	investigators	investigator	NNS
cord-003302-vxk7uqlc	45	3	have	have	VBP
cord-003302-vxk7uqlc	45	4	sought	seek	VBN
cord-003302-vxk7uqlc	45	5	to	to	TO
cord-003302-vxk7uqlc	45	6	explain	explain	VB
cord-003302-vxk7uqlc	45	7	the	the	DT
cord-003302-vxk7uqlc	45	8	greater	great	JJR
cord-003302-vxk7uqlc	45	9	mortality	mortality	NN
cord-003302-vxk7uqlc	45	10	among	among	IN
cord-003302-vxk7uqlc	45	11	adults	adult	NNS
cord-003302-vxk7uqlc	45	12	in	in	IN
cord-003302-vxk7uqlc	45	13	1918	1918	CD
cord-003302-vxk7uqlc	45	14	by	by	IN
cord-003302-vxk7uqlc	45	15	studying	study	VBG
cord-003302-vxk7uqlc	45	16	influenza	influenza	NN
cord-003302-vxk7uqlc	45	17	disease	disease	NN
cord-003302-vxk7uqlc	45	18	in	in	IN
cord-003302-vxk7uqlc	45	19	human	human	JJ
cord-003302-vxk7uqlc	45	20	populations	population	NNS
cord-003302-vxk7uqlc	45	21	.	.	.
cord-003302-vxk7uqlc	46	1	During	during	IN
cord-003302-vxk7uqlc	46	2	the	the	DT
cord-003302-vxk7uqlc	46	3	1918	1918	CD
cord-003302-vxk7uqlc	46	4	influenza	influenza	NN
cord-003302-vxk7uqlc	46	5	pandemic	pandemic	NN
cord-003302-vxk7uqlc	46	6	,	,	,
cord-003302-vxk7uqlc	46	7	children	child	NNS
cord-003302-vxk7uqlc	46	8	5	5	CD
cord-003302-vxk7uqlc	46	9	-	-	SYM
cord-003302-vxk7uqlc	46	10	14	14	CD
cord-003302-vxk7uqlc	46	11	years	year	NNS
cord-003302-vxk7uqlc	46	12	of	of	IN
cord-003302-vxk7uqlc	46	13	age	age	NN
cord-003302-vxk7uqlc	46	14	who	who	WP
cord-003302-vxk7uqlc	46	15	were	be	VBD
cord-003302-vxk7uqlc	46	16	living	live	VBG
cord-003302-vxk7uqlc	46	17	in	in	IN
cord-003302-vxk7uqlc	46	18	remote	remote	JJ
cord-003302-vxk7uqlc	46	19	,	,	,
cord-003302-vxk7uqlc	46	20	isolated	isolated	JJ
cord-003302-vxk7uqlc	46	21	communities	community	NNS
cord-003302-vxk7uqlc	46	22	were	be	VBD
cord-003302-vxk7uqlc	46	23	often	often	RB
cord-003302-vxk7uqlc	46	24	the	the	DT
cord-003302-vxk7uqlc	46	25	only	only	JJ
cord-003302-vxk7uqlc	46	26	ones	one	NNS
cord-003302-vxk7uqlc	46	27	to	to	TO
cord-003302-vxk7uqlc	46	28	survive	survive	VB
cord-003302-vxk7uqlc	46	29	[	[	-LRB-
cord-003302-vxk7uqlc	46	30	14	14	CD
cord-003302-vxk7uqlc	46	31	]	]	-RRB-
cord-003302-vxk7uqlc	46	32	.	.	.
cord-003302-vxk7uqlc	47	1	There	there	EX
cord-003302-vxk7uqlc	47	2	is	be	VBZ
cord-003302-vxk7uqlc	47	3	general	general	JJ
cord-003302-vxk7uqlc	47	4	agreement	agreement	NN
cord-003302-vxk7uqlc	47	5	that	that	WDT
cord-003302-vxk7uqlc	47	6	pandemic	pandemic	NN
cord-003302-vxk7uqlc	47	7	mortality	mortality	NN
cord-003302-vxk7uqlc	47	8	peaked	peak	VBD
cord-003302-vxk7uqlc	47	9	in	in	IN
cord-003302-vxk7uqlc	47	10	young	young	JJ
cord-003302-vxk7uqlc	47	11	adults	adult	NNS
cord-003302-vxk7uqlc	47	12	,	,	,
cord-003302-vxk7uqlc	47	13	but	but	CC
cord-003302-vxk7uqlc	47	14	it	-PRON-	PRP
cord-003302-vxk7uqlc	47	15	was	be	VBD
cord-003302-vxk7uqlc	47	16	much	much	RB
cord-003302-vxk7uqlc	47	17	lower	low	JJR
cord-003302-vxk7uqlc	47	18	in	in	IN
cord-003302-vxk7uqlc	47	19	adults	adult	NNS
cord-003302-vxk7uqlc	47	20	45	45	CD
cord-003302-vxk7uqlc	47	21	years	year	NNS
cord-003302-vxk7uqlc	47	22	of	of	IN
cord-003302-vxk7uqlc	47	23	age	age	NN
cord-003302-vxk7uqlc	48	1	(	(	-LRB-
cord-003302-vxk7uqlc	48	2	Fig	Fig	NNP
cord-003302-vxk7uqlc	48	3	.	.	NNP
cord-003302-vxk7uqlc	48	4	1	1	CD
cord-003302-vxk7uqlc	48	5	)	)	-RRB-
cord-003302-vxk7uqlc	48	6	.	.	.
cord-003302-vxk7uqlc	49	1	Their	-PRON-	PRP$
cord-003302-vxk7uqlc	49	2	lower	low	JJR
cord-003302-vxk7uqlc	49	3	mortality	mortality	NN
cord-003302-vxk7uqlc	49	4	is	be	VBZ
cord-003302-vxk7uqlc	49	5	thought	think	VBN
cord-003302-vxk7uqlc	49	6	due	due	IN
cord-003302-vxk7uqlc	49	7	to	to	IN
cord-003302-vxk7uqlc	49	8	the	the	DT
cord-003302-vxk7uqlc	49	9	protective	protective	JJ
cord-003302-vxk7uqlc	49	10	effect	effect	NN
cord-003302-vxk7uqlc	49	11	of	of	IN
cord-003302-vxk7uqlc	49	12	residual	residual	JJ
cord-003302-vxk7uqlc	49	13	immunity	immunity	NN
cord-003302-vxk7uqlc	49	14	following	follow	VBG
cord-003302-vxk7uqlc	49	15	exposure	exposure	NN
cord-003302-vxk7uqlc	49	16	to	to	IN
cord-003302-vxk7uqlc	49	17	H1N1-like	H1N1-like	VBG
cord-003302-vxk7uqlc	49	18	viruses	virus	NNS
cord-003302-vxk7uqlc	49	19	that	that	WDT
cord-003302-vxk7uqlc	49	20	circulated	circulate	VBD
cord-003302-vxk7uqlc	49	21	before	before	IN
cord-003302-vxk7uqlc	49	22	an	an	DT
cord-003302-vxk7uqlc	49	23	H3N2-like	H3N2-like	NNP
cord-003302-vxk7uqlc	49	24	virus	virus	NN
cord-003302-vxk7uqlc	49	25	(	(	-LRB-
cord-003302-vxk7uqlc	49	26	Russian	russian	JJ
cord-003302-vxk7uqlc	49	27	influenza	influenza	NN
cord-003302-vxk7uqlc	49	28	)	)	-RRB-
cord-003302-vxk7uqlc	49	29	appeared	appear	VBD
cord-003302-vxk7uqlc	49	30	in	in	IN
cord-003302-vxk7uqlc	49	31	the	the	DT
cord-003302-vxk7uqlc	49	32	early	early	JJ
cord-003302-vxk7uqlc	49	33	1890s	1890s	CD
cord-003302-vxk7uqlc	49	34	[	[	-LRB-
cord-003302-vxk7uqlc	49	35	10	10	CD
cord-003302-vxk7uqlc	49	36	]	]	-RRB-
cord-003302-vxk7uqlc	49	37	.	.	.
cord-003302-vxk7uqlc	50	1	Influenza	influenza	NN
cord-003302-vxk7uqlc	50	2	virologists	virologist	NNS
cord-003302-vxk7uqlc	50	3	agree	agree	VBP
cord-003302-vxk7uqlc	50	4	that	that	IN
cord-003302-vxk7uqlc	50	5	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	50	6	priming	priming	NN
cord-003302-vxk7uqlc	50	7	following	follow	VBG
cord-003302-vxk7uqlc	50	8	infection	infection	NN
cord-003302-vxk7uqlc	50	9	with	with	IN
cord-003302-vxk7uqlc	50	10	these	these	DT
cord-003302-vxk7uqlc	50	11	earlier	early	JJR
cord-003302-vxk7uqlc	50	12	H1N1viruses	h1n1viruse	NNS
cord-003302-vxk7uqlc	50	13	(	(	-LRB-
cord-003302-vxk7uqlc	50	14	known	know	VBN
cord-003302-vxk7uqlc	50	15	as	as	IN
cord-003302-vxk7uqlc	50	16	'	'	``
cord-003302-vxk7uqlc	50	17	original	original	JJ
cord-003302-vxk7uqlc	50	18	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	50	19	sin	sin	NN
cord-003302-vxk7uqlc	50	20	'	'	''
cord-003302-vxk7uqlc	50	21	)	)	-RRB-
cord-003302-vxk7uqlc	50	22	provided	provide	VBD
cord-003302-vxk7uqlc	50	23	some	some	DT
cord-003302-vxk7uqlc	50	24	measure	measure	NN
cord-003302-vxk7uqlc	50	25	of	of	IN
cord-003302-vxk7uqlc	50	26	long	long	RB
cord-003302-vxk7uqlc	50	27	-	-	HYPH
cord-003302-vxk7uqlc	50	28	lasting	last	VBG
cord-003302-vxk7uqlc	50	29	protection	protection	NN
cord-003302-vxk7uqlc	50	30	against	against	IN
cord-003302-vxk7uqlc	50	31	the	the	DT
cord-003302-vxk7uqlc	50	32	highly	highly	RB
cord-003302-vxk7uqlc	50	33	virulent	virulent	JJ
cord-003302-vxk7uqlc	50	34	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	50	35	virus	virus	NN
cord-003302-vxk7uqlc	50	36	that	that	WDT
cord-003302-vxk7uqlc	50	37	emerged	emerge	VBD
cord-003302-vxk7uqlc	50	38	in	in	IN
cord-003302-vxk7uqlc	50	39	1918	1918	CD
cord-003302-vxk7uqlc	50	40	[	[	-LRB-
cord-003302-vxk7uqlc	50	41	15	15	CD
cord-003302-vxk7uqlc	50	42	]	]	-RRB-
cord-003302-vxk7uqlc	50	43	.	.	.
cord-003302-vxk7uqlc	51	1	Accordingly	accordingly	RB
cord-003302-vxk7uqlc	51	2	,	,	,
cord-003302-vxk7uqlc	51	3	individuals	individual	NNS
cord-003302-vxk7uqlc	51	4	born	bear	VBN
cord-003302-vxk7uqlc	51	5	after	after	IN
cord-003302-vxk7uqlc	51	6	the	the	DT
cord-003302-vxk7uqlc	51	7	early	early	JJ
cord-003302-vxk7uqlc	51	8	1890s	1890	NNS
cord-003302-vxk7uqlc	51	9	were	be	VBD
cord-003302-vxk7uqlc	51	10	exposed	expose	VBN
cord-003302-vxk7uqlc	51	11	only	only	RB
cord-003302-vxk7uqlc	51	12	to	to	IN
cord-003302-vxk7uqlc	51	13	H3N2-like	H3N2-like	NNP
cord-003302-vxk7uqlc	51	14	viruses	virus	NNS
cord-003302-vxk7uqlc	51	15	and	and	CC
cord-003302-vxk7uqlc	51	16	would	would	MD
cord-003302-vxk7uqlc	51	17	have	have	VB
cord-003302-vxk7uqlc	51	18	missed	miss	VBN
cord-003302-vxk7uqlc	51	19	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	51	20	priming	priming	NN
cord-003302-vxk7uqlc	51	21	with	with	IN
cord-003302-vxk7uqlc	51	22	pre-1890	pre-1890	JJ
cord-003302-vxk7uqlc	51	23	H1N1-like	H1N1-like	NNP
cord-003302-vxk7uqlc	51	24	viruses	virus	NNS
cord-003302-vxk7uqlc	51	25	.	.	.
cord-003302-vxk7uqlc	52	1	As	as	IN
cord-003302-vxk7uqlc	52	2	young	young	JJ
cord-003302-vxk7uqlc	52	3	adults	adult	NNS
cord-003302-vxk7uqlc	52	4	in	in	IN
cord-003302-vxk7uqlc	52	5	1918	1918	CD
cord-003302-vxk7uqlc	52	6	,	,	,
cord-003302-vxk7uqlc	52	7	they	-PRON-	PRP
cord-003302-vxk7uqlc	52	8	were	be	VBD
cord-003302-vxk7uqlc	52	9	susceptible	susceptible	JJ
cord-003302-vxk7uqlc	52	10	to	to	IN
cord-003302-vxk7uqlc	52	11	infection	infection	NN
cord-003302-vxk7uqlc	52	12	with	with	IN
cord-003302-vxk7uqlc	52	13	the	the	DT
cord-003302-vxk7uqlc	52	14	new	new	JJ
cord-003302-vxk7uqlc	52	15	pandemic	pandemic	NN
cord-003302-vxk7uqlc	52	16	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	52	17	virus	virus	NN
cord-003302-vxk7uqlc	52	18	.	.	.
cord-003302-vxk7uqlc	53	1	Influenza	Influenza	NNP
cord-003302-vxk7uqlc	53	2	A	a	DT
cord-003302-vxk7uqlc	53	3	viruses	virus	NNS
cord-003302-vxk7uqlc	53	4	are	be	VBP
cord-003302-vxk7uqlc	53	5	categorized	categorize	VBN
cord-003302-vxk7uqlc	53	6	into	into	IN
cord-003302-vxk7uqlc	53	7	two	two	CD
cord-003302-vxk7uqlc	53	8	groups	group	NNS
cord-003302-vxk7uqlc	53	9	.	.	.
cord-003302-vxk7uqlc	54	1	Group	group	NN
cord-003302-vxk7uqlc	54	2	1	1	CD
cord-003302-vxk7uqlc	54	3	includes	include	VBZ
cord-003302-vxk7uqlc	54	4	H1	h1	NN
cord-003302-vxk7uqlc	54	5	,	,	,
cord-003302-vxk7uqlc	54	6	H2	H2	NNP
cord-003302-vxk7uqlc	54	7	and	and	CC
cord-003302-vxk7uqlc	54	8	H5	H5	NNP
cord-003302-vxk7uqlc	54	9	subtypes	subtype	NNS
cord-003302-vxk7uqlc	54	10	,	,	,
cord-003302-vxk7uqlc	54	11	whereas	whereas	IN
cord-003302-vxk7uqlc	54	12	Group	Group	NNP
cord-003302-vxk7uqlc	54	13	2	2	CD
cord-003302-vxk7uqlc	54	14	includes	include	VBZ
cord-003302-vxk7uqlc	54	15	H3	H3	NNP
cord-003302-vxk7uqlc	54	16	and	and	CC
cord-003302-vxk7uqlc	54	17	H7	H7	NNP
cord-003302-vxk7uqlc	54	18	subtypes	subtype	NNS
cord-003302-vxk7uqlc	55	1	(	(	-LRB-
cord-003302-vxk7uqlc	55	2	Figure	figure	NN
cord-003302-vxk7uqlc	55	3	1A	1a	NN
cord-003302-vxk7uqlc	55	4	in	in	IN
cord-003302-vxk7uqlc	55	5	Ref	Ref	NNP
cord-003302-vxk7uqlc	55	6	.	.	.
cord-003302-vxk7uqlc	56	1	[	[	-LRB-
cord-003302-vxk7uqlc	56	2	16	16	CD
cord-003302-vxk7uqlc	56	3	]	]	-RRB-
cord-003302-vxk7uqlc	56	4	)	)	-RRB-
cord-003302-vxk7uqlc	56	5	.	.	.
cord-003302-vxk7uqlc	57	1	This	this	DT
cord-003302-vxk7uqlc	57	2	phylogenetic	phylogenetic	JJ
cord-003302-vxk7uqlc	57	3	understanding	understanding	NN
cord-003302-vxk7uqlc	57	4	has	have	VBZ
cord-003302-vxk7uqlc	57	5	informed	inform	VBN
cord-003302-vxk7uqlc	57	6	recent	recent	JJ
cord-003302-vxk7uqlc	57	7	age	age	NN
cord-003302-vxk7uqlc	57	8	-	-	HYPH
cord-003302-vxk7uqlc	57	9	specific	specific	JJ
cord-003302-vxk7uqlc	57	10	analyses	analysis	NNS
cord-003302-vxk7uqlc	57	11	(	(	-LRB-
cord-003302-vxk7uqlc	57	12	based	base	VBN
cord-003302-vxk7uqlc	57	13	on	on	IN
cord-003302-vxk7uqlc	57	14	individual	individual	JJ
cord-003302-vxk7uqlc	57	15	birth	birth	NN
cord-003302-vxk7uqlc	57	16	year	year	NN
cord-003302-vxk7uqlc	57	17	)	)	-RRB-
cord-003302-vxk7uqlc	57	18	of	of	IN
cord-003302-vxk7uqlc	57	19	mortality	mortality	NN
cord-003302-vxk7uqlc	57	20	patterns	pattern	NNS
cord-003302-vxk7uqlc	57	21	before	before	RB
cord-003302-vxk7uqlc	57	22	,	,	,
cord-003302-vxk7uqlc	57	23	during	during	IN
cord-003302-vxk7uqlc	57	24	and	and	CC
cord-003302-vxk7uqlc	57	25	after	after	IN
cord-003302-vxk7uqlc	57	26	the	the	DT
cord-003302-vxk7uqlc	57	27	1918	1918	CD
cord-003302-vxk7uqlc	57	28	pandemic	pandemic	NN
cord-003302-vxk7uqlc	57	29	[	[	-LRB-
cord-003302-vxk7uqlc	57	30	17	17	CD
cord-003302-vxk7uqlc	57	31	]	]	-RRB-
cord-003302-vxk7uqlc	57	32	[	[	-LRB-
cord-003302-vxk7uqlc	57	33	18	18	CD
cord-003302-vxk7uqlc	57	34	]	]	-RRB-
cord-003302-vxk7uqlc	57	35	[	[	-LRB-
cord-003302-vxk7uqlc	57	36	19	19	CD
cord-003302-vxk7uqlc	57	37	]	]	-RRB-
cord-003302-vxk7uqlc	57	38	[	[	-LRB-
cord-003302-vxk7uqlc	57	39	20	20	CD
cord-003302-vxk7uqlc	57	40	]	]	-RRB-
cord-003302-vxk7uqlc	57	41	[	[	-LRB-
cord-003302-vxk7uqlc	57	42	21	21	CD
cord-003302-vxk7uqlc	57	43	]	]	-RRB-
cord-003302-vxk7uqlc	57	44	.	.	.
cord-003302-vxk7uqlc	58	1	Worobey	Worobey	NNP
cord-003302-vxk7uqlc	58	2	et	et	NNP
cord-003302-vxk7uqlc	58	3	al	al	NNP
cord-003302-vxk7uqlc	58	4	.	.	NNP
cord-003302-vxk7uqlc	58	5	have	have	VBP
cord-003302-vxk7uqlc	58	6	used	use	VBN
cord-003302-vxk7uqlc	58	7	a	a	DT
cord-003302-vxk7uqlc	58	8	hostspecific	hostspecific	NNP
cord-003302-vxk7uqlc	58	9	molecular	molecular	JJ
cord-003302-vxk7uqlc	58	10	clock	clock	NN
cord-003302-vxk7uqlc	58	11	approach	approach	NN
cord-003302-vxk7uqlc	58	12	to	to	TO
cord-003302-vxk7uqlc	58	13	demonstrate	demonstrate	VB
cord-003302-vxk7uqlc	58	14	that	that	IN
cord-003302-vxk7uqlc	58	15	high	high	JJ
cord-003302-vxk7uqlc	58	16	mortality	mortality	NN
cord-003302-vxk7uqlc	58	17	in	in	IN
cord-003302-vxk7uqlc	58	18	young	young	JJ
cord-003302-vxk7uqlc	58	19	adults	adult	NNS
cord-003302-vxk7uqlc	58	20	may	may	MD
cord-003302-vxk7uqlc	58	21	have	have	VB
cord-003302-vxk7uqlc	58	22	been	be	VBN
cord-003302-vxk7uqlc	58	23	due	due	JJ
cord-003302-vxk7uqlc	58	24	to	to	IN
cord-003302-vxk7uqlc	58	25	childhood	childhood	NN
cord-003302-vxk7uqlc	58	26	exposure	exposure	NN
cord-003302-vxk7uqlc	58	27	to	to	IN
cord-003302-vxk7uqlc	58	28	a	a	DT
cord-003302-vxk7uqlc	58	29	doubly	doubly	RB
cord-003302-vxk7uqlc	58	30	heterosubtypic	heterosubtypic	JJ
cord-003302-vxk7uqlc	58	31	putative	putative	JJ
cord-003302-vxk7uqlc	58	32	H3N8	H3N8	NNP
cord-003302-vxk7uqlc	58	33	virus	virus	NN
cord-003302-vxk7uqlc	58	34	that	that	WDT
cord-003302-vxk7uqlc	58	35	circulated	circulate	VBD
cord-003302-vxk7uqlc	58	36	from	from	IN
cord-003302-vxk7uqlc	58	37	1889	1889	CD
cord-003302-vxk7uqlc	58	38	to	to	IN
cord-003302-vxk7uqlc	58	39	1900	1900	CD
cord-003302-vxk7uqlc	58	40	[	[	-LRB-
cord-003302-vxk7uqlc	58	41	19	19	CD
cord-003302-vxk7uqlc	58	42	]	]	-RRB-
cord-003302-vxk7uqlc	58	43	.	.	.
cord-003302-vxk7uqlc	59	1	They	-PRON-	PRP
cord-003302-vxk7uqlc	59	2	think	think	VBP
cord-003302-vxk7uqlc	59	3	that	that	IN
cord-003302-vxk7uqlc	59	4	young	young	JJ
cord-003302-vxk7uqlc	59	5	children	child	NNS
cord-003302-vxk7uqlc	59	6	(	(	-LRB-
cord-003302-vxk7uqlc	59	7	but	but	CC
cord-003302-vxk7uqlc	59	8	not	not	RB
cord-003302-vxk7uqlc	59	9	infants	infant	NNS
cord-003302-vxk7uqlc	59	10	)	)	-RRB-
cord-003302-vxk7uqlc	59	11	were	be	VBD
cord-003302-vxk7uqlc	59	12	protected	protect	VBN
cord-003302-vxk7uqlc	59	13	by	by	IN
cord-003302-vxk7uqlc	59	14	childhood	childhood	NN
cord-003302-vxk7uqlc	59	15	exposure	exposure	NN
cord-003302-vxk7uqlc	59	16	to	to	IN
cord-003302-vxk7uqlc	59	17	a	a	DT
cord-003302-vxk7uqlc	59	18	newly	newly	RB
cord-003302-vxk7uqlc	59	19	emerged	emerge	VBN
cord-003302-vxk7uqlc	59	20	(	(	-LRB-
cord-003302-vxk7uqlc	59	21	post-1900	post-1900	NNP
cord-003302-vxk7uqlc	59	22	)	)	-RRB-
cord-003302-vxk7uqlc	59	23	H1variant	h1variant	NN
cord-003302-vxk7uqlc	59	24	or	or	CC
cord-003302-vxk7uqlc	59	25	N1	n1	NN
cord-003302-vxk7uqlc	59	26	antigens	antigen	NNS
cord-003302-vxk7uqlc	59	27	.	.	.
cord-003302-vxk7uqlc	60	1	Miller	Miller	NNP
cord-003302-vxk7uqlc	60	2	et	et	NNP
cord-003302-vxk7uqlc	60	3	al	al	NNP
cord-003302-vxk7uqlc	60	4	.	.	.
cord-003302-vxk7uqlc	61	1	interpret	interpret	VB
cord-003302-vxk7uqlc	61	2	the	the	DT
cord-003302-vxk7uqlc	61	3	historical	historical	JJ
cord-003302-vxk7uqlc	61	4	data	datum	NNS
cord-003302-vxk7uqlc	61	5	more	more	RBR
cord-003302-vxk7uqlc	61	6	cautiously	cautiously	RB
cord-003302-vxk7uqlc	61	7	[	[	-LRB-
cord-003302-vxk7uqlc	61	8	18	18	CD
cord-003302-vxk7uqlc	61	9	,	,	,
cord-003302-vxk7uqlc	61	10	20	20	CD
cord-003302-vxk7uqlc	61	11	]	]	-RRB-
cord-003302-vxk7uqlc	61	12	.	.	.
cord-003302-vxk7uqlc	62	1	They	-PRON-	PRP
cord-003302-vxk7uqlc	62	2	agree	agree	VBP
cord-003302-vxk7uqlc	62	3	with	with	IN
cord-003302-vxk7uqlc	62	4	Worobey	Worobey	NNP
cord-003302-vxk7uqlc	62	5	et	et	NNP
cord-003302-vxk7uqlc	62	6	al	al	NNP
cord-003302-vxk7uqlc	62	7	that	that	IN
cord-003302-vxk7uqlc	62	8	early	early	JJ
cord-003302-vxk7uqlc	62	9	life	life	NN
cord-003302-vxk7uqlc	62	10	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	62	11	imprinting	imprinting	NN
cord-003302-vxk7uqlc	62	12	might	may	MD
cord-003302-vxk7uqlc	62	13	have	have	VB
cord-003302-vxk7uqlc	62	14	led	lead	VBN
cord-003302-vxk7uqlc	62	15	to	to	IN
cord-003302-vxk7uqlc	62	16	a	a	DT
cord-003302-vxk7uqlc	62	17	dysregulated	dysregulate	VBN
cord-003302-vxk7uqlc	62	18	T	t	NN
cord-003302-vxk7uqlc	62	19	-	-	HYPH
cord-003302-vxk7uqlc	62	20	cell	cell	NN
cord-003302-vxk7uqlc	62	21	response	response	NN
cord-003302-vxk7uqlc	62	22	that	that	WDT
cord-003302-vxk7uqlc	62	23	increased	increase	VBD
cord-003302-vxk7uqlc	62	24	the	the	DT
cord-003302-vxk7uqlc	62	25	risk	risk	NN
cord-003302-vxk7uqlc	62	26	of	of	IN
cord-003302-vxk7uqlc	62	27	death	death	NN
cord-003302-vxk7uqlc	62	28	following	follow	VBG
cord-003302-vxk7uqlc	62	29	infection	infection	NN
cord-003302-vxk7uqlc	62	30	in	in	IN
cord-003302-vxk7uqlc	62	31	1918	1918	CD
cord-003302-vxk7uqlc	62	32	with	with	IN
cord-003302-vxk7uqlc	62	33	a	a	DT
cord-003302-vxk7uqlc	62	34	new	new	JJ
cord-003302-vxk7uqlc	62	35	and	and	CC
cord-003302-vxk7uqlc	62	36	antigenically	antigenically	RB
cord-003302-vxk7uqlc	62	37	dissimilar	dissimilar	JJ
cord-003302-vxk7uqlc	62	38	influenza	influenza	NN
cord-003302-vxk7uqlc	62	39	virus	virus	NN
cord-003302-vxk7uqlc	62	40	.	.	.
cord-003302-vxk7uqlc	63	1	However	however	RB
cord-003302-vxk7uqlc	63	2	,	,	,
cord-003302-vxk7uqlc	63	3	they	-PRON-	PRP
cord-003302-vxk7uqlc	63	4	question	question	VBP
cord-003302-vxk7uqlc	63	5	whether	whether	IN
cord-003302-vxk7uqlc	63	6	a	a	DT
cord-003302-vxk7uqlc	63	7	new	new	JJ
cord-003302-vxk7uqlc	63	8	H1	H1	NNP
cord-003302-vxk7uqlc	63	9	virus	virus	NN
cord-003302-vxk7uqlc	63	10	emerged	emerge	VBD
cord-003302-vxk7uqlc	63	11	in	in	IN
cord-003302-vxk7uqlc	63	12	the	the	DT
cord-003302-vxk7uqlc	63	13	early	early	JJ
cord-003302-vxk7uqlc	63	14	1900s	1900s	CD
cord-003302-vxk7uqlc	63	15	to	to	TO
cord-003302-vxk7uqlc	63	16	replace	replace	VB
cord-003302-vxk7uqlc	63	17	the	the	DT
cord-003302-vxk7uqlc	63	18	H3	H3	NNP
cord-003302-vxk7uqlc	63	19	virus	virus	NN
cord-003302-vxk7uqlc	63	20	that	that	WDT
cord-003302-vxk7uqlc	63	21	first	first	RB
cord-003302-vxk7uqlc	63	22	appeared	appear	VBD
cord-003302-vxk7uqlc	63	23	in	in	IN
cord-003302-vxk7uqlc	63	24	1890	1890	CD
cord-003302-vxk7uqlc	63	25	.	.	.
cord-003302-vxk7uqlc	64	1	Worobey	Worobey	NNP
cord-003302-vxk7uqlc	64	2	et	et	NNP
cord-003302-vxk7uqlc	64	3	al	al	NNP
cord-003302-vxk7uqlc	64	4	have	have	VBP
cord-003302-vxk7uqlc	64	5	also	also	RB
cord-003302-vxk7uqlc	64	6	analyzed	analyze	VBN
cord-003302-vxk7uqlc	64	7	cases	case	NNS
cord-003302-vxk7uqlc	64	8	and	and	CC
cord-003302-vxk7uqlc	64	9	deaths	death	NNS
cord-003302-vxk7uqlc	64	10	due	due	JJ
cord-003302-vxk7uqlc	64	11	to	to	IN
cord-003302-vxk7uqlc	64	12	H5N1	H5N1	NNP
cord-003302-vxk7uqlc	64	13	and	and	CC
cord-003302-vxk7uqlc	64	14	H7N9	H7N9	NNP
cord-003302-vxk7uqlc	64	15	influenza	influenza	NN
cord-003302-vxk7uqlc	64	16	.	.	.
cord-003302-vxk7uqlc	65	1	They	-PRON-	PRP
cord-003302-vxk7uqlc	65	2	have	have	VBP
cord-003302-vxk7uqlc	65	3	shown	show	VBN
cord-003302-vxk7uqlc	65	4	that	that	IN
cord-003302-vxk7uqlc	65	5	HA	HA	NNP
cord-003302-vxk7uqlc	65	6	imprinting	imprinting	NN
cord-003302-vxk7uqlc	65	7	was	be	VBD
cord-003302-vxk7uqlc	65	8	"	"	``
cord-003302-vxk7uqlc	65	9	the	the	DT
cord-003302-vxk7uqlc	65	10	dominant	dominant	JJ
cord-003302-vxk7uqlc	65	11	explanatory	explanatory	JJ
cord-003302-vxk7uqlc	65	12	factor	factor	NN
cord-003302-vxk7uqlc	65	13	for	for	IN
cord-003302-vxk7uqlc	65	14	observed	observed	JJ
cord-003302-vxk7uqlc	65	15	incidence	incidence	NN
cord-003302-vxk7uqlc	65	16	and	and	CC
cord-003302-vxk7uqlc	65	17	mortality	mortality	NN
cord-003302-vxk7uqlc	65	18	patterns	pattern	NNS
cord-003302-vxk7uqlc	65	19	for	for	IN
cord-003302-vxk7uqlc	65	20	both	both	CC
cord-003302-vxk7uqlc	65	21	H5N1	H5N1	NNP
cord-003302-vxk7uqlc	65	22	and	and	CC
cord-003302-vxk7uqlc	65	23	H7N9	H7N9	NNP
cord-003302-vxk7uqlc	65	24	"	"	''
cord-003302-vxk7uqlc	65	25	[	[	-LRB-
cord-003302-vxk7uqlc	65	26	21	21	CD
cord-003302-vxk7uqlc	65	27	]	]	-RRB-
cord-003302-vxk7uqlc	65	28	.	.	.
cord-003302-vxk7uqlc	66	1	For	for	IN
cord-003302-vxk7uqlc	66	2	example	example	NN
cord-003302-vxk7uqlc	66	3	,	,	,
cord-003302-vxk7uqlc	66	4	individuals	individual	NNS
cord-003302-vxk7uqlc	66	5	born	bear	VBN
cord-003302-vxk7uqlc	66	6	during	during	IN
cord-003302-vxk7uqlc	66	7	the	the	DT
cord-003302-vxk7uqlc	66	8	period	period	NN
cord-003302-vxk7uqlc	66	9	when	when	WRB
cord-003302-vxk7uqlc	66	10	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	66	11	viruses	virus	NNS
cord-003302-vxk7uqlc	66	12	circulated	circulate	VBN
cord-003302-vxk7uqlc	66	13	were	be	VBD
cord-003302-vxk7uqlc	66	14	protected	protect	VBN
cord-003302-vxk7uqlc	66	15	against	against	IN
cord-003302-vxk7uqlc	66	16	H5N1	H5N1	NNP
cord-003302-vxk7uqlc	66	17	infection	infection	NN
cord-003302-vxk7uqlc	66	18	(	(	-LRB-
cord-003302-vxk7uqlc	66	19	both	both	DT
cord-003302-vxk7uqlc	66	20	are	be	VBP
cord-003302-vxk7uqlc	66	21	Group	group	NN
cord-003302-vxk7uqlc	66	22	1	1	CD
cord-003302-vxk7uqlc	66	23	viruses	virus	NNS
cord-003302-vxk7uqlc	66	24	)	)	-RRB-
cord-003302-vxk7uqlc	66	25	but	but	CC
cord-003302-vxk7uqlc	66	26	were	be	VBD
cord-003302-vxk7uqlc	66	27	at	at	IN
cord-003302-vxk7uqlc	66	28	increased	increase	VBN
cord-003302-vxk7uqlc	66	29	risk	risk	NN
cord-003302-vxk7uqlc	66	30	of	of	IN
cord-003302-vxk7uqlc	66	31	H7N9	H7N9	NNP
cord-003302-vxk7uqlc	66	32	infection	infection	NN
cord-003302-vxk7uqlc	66	33	(	(	-LRB-
cord-003302-vxk7uqlc	66	34	a	a	DT
cord-003302-vxk7uqlc	66	35	Group	Group	NNP
cord-003302-vxk7uqlc	66	36	2	2	CD
cord-003302-vxk7uqlc	66	37	virus	virus	NN
cord-003302-vxk7uqlc	66	38	)	)	-RRB-
cord-003302-vxk7uqlc	66	39	[	[	-LRB-
cord-003302-vxk7uqlc	66	40	21	21	CD
cord-003302-vxk7uqlc	66	41	]	]	-RRB-
cord-003302-vxk7uqlc	66	42	.	.	.
cord-003302-vxk7uqlc	67	1	However	however	RB
cord-003302-vxk7uqlc	67	2	,	,	,
cord-003302-vxk7uqlc	67	3	individuals	individual	NNS
cord-003302-vxk7uqlc	67	4	born	bear	VBN
cord-003302-vxk7uqlc	67	5	during	during	IN
cord-003302-vxk7uqlc	67	6	the	the	DT
cord-003302-vxk7uqlc	67	7	1968	1968	CD
cord-003302-vxk7uqlc	67	8	-	-	SYM
cord-003302-vxk7uqlc	67	9	2015	2015	CD
cord-003302-vxk7uqlc	67	10	period	period	NN
cord-003302-vxk7uqlc	67	11	(	(	-LRB-
cord-003302-vxk7uqlc	67	12	the	the	DT
cord-003302-vxk7uqlc	67	13	H3N2	H3N2	NNP
cord-003302-vxk7uqlc	67	14	era	era	NN
cord-003302-vxk7uqlc	67	15	)	)	-RRB-
cord-003302-vxk7uqlc	67	16	were	be	VBD
cord-003302-vxk7uqlc	67	17	protected	protect	VBN
cord-003302-vxk7uqlc	67	18	against	against	IN
cord-003302-vxk7uqlc	67	19	H7N9	H7N9	NNP
cord-003302-vxk7uqlc	67	20	infection	infection	NN
cord-003302-vxk7uqlc	67	21	(	(	-LRB-
cord-003302-vxk7uqlc	67	22	both	both	DT
cord-003302-vxk7uqlc	67	23	are	be	VBP
cord-003302-vxk7uqlc	67	24	Group	group	NN
cord-003302-vxk7uqlc	67	25	2	2	CD
cord-003302-vxk7uqlc	67	26	viruses	virus	NNS
cord-003302-vxk7uqlc	67	27	)	)	-RRB-
cord-003302-vxk7uqlc	67	28	,	,	,
cord-003302-vxk7uqlc	67	29	whereas	whereas	IN
cord-003302-vxk7uqlc	67	30	those	those	DT
cord-003302-vxk7uqlc	67	31	born	bear	VBN
cord-003302-vxk7uqlc	67	32	before	before	IN
cord-003302-vxk7uqlc	67	33	1957	1957	CD
cord-003302-vxk7uqlc	67	34	(	(	-LRB-
cord-003302-vxk7uqlc	67	35	the	the	DT
cord-003302-vxk7uqlc	67	36	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	67	37	era	era	NN
cord-003302-vxk7uqlc	67	38	)	)	-RRB-
cord-003302-vxk7uqlc	67	39	were	be	VBD
cord-003302-vxk7uqlc	67	40	not	not	RB
cord-003302-vxk7uqlc	67	41	.	.	.
cord-003302-vxk7uqlc	68	1	The	the	DT
cord-003302-vxk7uqlc	68	2	importance	importance	NN
cord-003302-vxk7uqlc	68	3	of	of	IN
cord-003302-vxk7uqlc	68	4	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	68	5	imprinting	imprinting	NN
cord-003302-vxk7uqlc	68	6	was	be	VBD
cord-003302-vxk7uqlc	68	7	also	also	RB
cord-003302-vxk7uqlc	68	8	shown	show	VBN
cord-003302-vxk7uqlc	68	9	for	for	IN
cord-003302-vxk7uqlc	68	10	the	the	DT
cord-003302-vxk7uqlc	68	11	2009	2009	CD
cord-003302-vxk7uqlc	68	12	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	68	13	pandemic	pandemic	NN
cord-003302-vxk7uqlc	68	14	.	.	.
cord-003302-vxk7uqlc	69	1	Individuals	individual	NNS
cord-003302-vxk7uqlc	69	2	born	bear	VBN
cord-003302-vxk7uqlc	69	3	before	before	IN
cord-003302-vxk7uqlc	69	4	1957	1957	CD
cord-003302-vxk7uqlc	69	5	were	be	VBD
cord-003302-vxk7uqlc	69	6	exposed	expose	VBN
cord-003302-vxk7uqlc	69	7	to	to	IN
cord-003302-vxk7uqlc	69	8	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	69	9	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	69	10	viruses	virus	NNS
cord-003302-vxk7uqlc	69	11	before	before	IN
cord-003302-vxk7uqlc	69	12	the	the	DT
cord-003302-vxk7uqlc	69	13	emergence	emergence	NN
cord-003302-vxk7uqlc	69	14	of	of	IN
cord-003302-vxk7uqlc	69	15	the	the	DT
cord-003302-vxk7uqlc	69	16	new	new	JJ
cord-003302-vxk7uqlc	69	17	H2N2	H2N2	NNP
cord-003302-vxk7uqlc	69	18	pandemic	pandemic	NN
cord-003302-vxk7uqlc	69	19	virus	virus	NN
cord-003302-vxk7uqlc	69	20	in	in	IN
cord-003302-vxk7uqlc	69	21	1957	1957	CD
cord-003302-vxk7uqlc	69	22	.	.	.
cord-003302-vxk7uqlc	70	1	As	as	IN
cord-003302-vxk7uqlc	70	2	older	old	JJR
cord-003302-vxk7uqlc	70	3	individuals	individual	NNS
cord-003302-vxk7uqlc	70	4	,	,	,
cord-003302-vxk7uqlc	70	5	they	-PRON-	PRP
cord-003302-vxk7uqlc	70	6	experienced	experience	VBD
cord-003302-vxk7uqlc	70	7	a	a	DT
cord-003302-vxk7uqlc	70	8	lower	low	JJR
cord-003302-vxk7uqlc	70	9	incidence	incidence	NN
cord-003302-vxk7uqlc	70	10	of	of	IN
cord-003302-vxk7uqlc	70	11	pH1N1	pH1N1	NNP
cord-003302-vxk7uqlc	70	12	disease	disease	NN
cord-003302-vxk7uqlc	70	13	in	in	IN
cord-003302-vxk7uqlc	70	14	2009	2009	CD
cord-003302-vxk7uqlc	70	15	than	than	IN
cord-003302-vxk7uqlc	70	16	those	those	DT
cord-003302-vxk7uqlc	70	17	born	bear	VBN
cord-003302-vxk7uqlc	70	18	after	after	IN
cord-003302-vxk7uqlc	70	19	1957	1957	CD
cord-003302-vxk7uqlc	70	20	[	[	-LRB-
cord-003302-vxk7uqlc	70	21	22	22	CD
cord-003302-vxk7uqlc	70	22	]	]	-RRB-
cord-003302-vxk7uqlc	70	23	.	.	.
cord-003302-vxk7uqlc	71	1	However	however	RB
cord-003302-vxk7uqlc	71	2	,	,	,
cord-003302-vxk7uqlc	71	3	Miller	Miller	NNP
cord-003302-vxk7uqlc	71	4	et	et	NNP
cord-003302-vxk7uqlc	71	5	al	al	NNP
cord-003302-vxk7uqlc	71	6	.	.	NNP
cord-003302-vxk7uqlc	71	7	have	have	VBP
cord-003302-vxk7uqlc	71	8	argued	argue	VBN
cord-003302-vxk7uqlc	71	9	that	that	IN
cord-003302-vxk7uqlc	71	10	early	early	JJ
cord-003302-vxk7uqlc	71	11	life	life	NN
cord-003302-vxk7uqlc	71	12	H2N2	H2N2	NNP
cord-003302-vxk7uqlc	71	13	virus	virus	NN
cord-003302-vxk7uqlc	71	14	infection	infection	NN
cord-003302-vxk7uqlc	71	15	may	may	MD
cord-003302-vxk7uqlc	71	16	have	have	VB
cord-003302-vxk7uqlc	71	17	actually	actually	RB
cord-003302-vxk7uqlc	71	18	increased	increase	VBN
cord-003302-vxk7uqlc	71	19	the	the	DT
cord-003302-vxk7uqlc	71	20	risk	risk	NN
cord-003302-vxk7uqlc	71	21	of	of	IN
cord-003302-vxk7uqlc	71	22	death	death	NN
cord-003302-vxk7uqlc	71	23	during	during	IN
cord-003302-vxk7uqlc	71	24	the	the	DT
cord-003302-vxk7uqlc	71	25	heterotypic	heterotypic	NNP
cord-003302-vxk7uqlc	71	26	2009	2009	CD
cord-003302-vxk7uqlc	71	27	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	71	28	pandemic	pandemic	NN
cord-003302-vxk7uqlc	71	29	[	[	-LRB-
cord-003302-vxk7uqlc	71	30	23	23	CD
cord-003302-vxk7uqlc	71	31	]	]	-RRB-
cord-003302-vxk7uqlc	71	32	.	.	.
cord-003302-vxk7uqlc	72	1	The	the	DT
cord-003302-vxk7uqlc	72	2	importance	importance	NN
cord-003302-vxk7uqlc	72	3	of	of	IN
cord-003302-vxk7uqlc	72	4	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	72	5	imprinting	imprinting	NN
cord-003302-vxk7uqlc	72	6	for	for	IN
cord-003302-vxk7uqlc	72	7	human	human	JJ
cord-003302-vxk7uqlc	72	8	influenza	influenza	NN
cord-003302-vxk7uqlc	72	9	is	be	VBZ
cord-003302-vxk7uqlc	72	10	undeniable	undeniable	JJ
cord-003302-vxk7uqlc	72	11	.	.	.
cord-003302-vxk7uqlc	72	12	'	'	''
cord-003302-vxk7uqlc	73	1	First	first	JJ
cord-003302-vxk7uqlc	73	2	flu	flu	NN
cord-003302-vxk7uqlc	73	3	'	'	''
cord-003302-vxk7uqlc	73	4	may	may	MD
cord-003302-vxk7uqlc	73	5	indeed	indeed	RB
cord-003302-vxk7uqlc	73	6	be	be	VB
cord-003302-vxk7uqlc	73	7	'	'	``
cord-003302-vxk7uqlc	73	8	forever	forever	RB
cord-003302-vxk7uqlc	73	9	'	'	''
cord-003302-vxk7uqlc	73	10	[	[	-LRB-
cord-003302-vxk7uqlc	73	11	24	24	CD
cord-003302-vxk7uqlc	73	12	]	]	-RRB-
cord-003302-vxk7uqlc	73	13	,	,	,
cord-003302-vxk7uqlc	73	14	but	but	CC
cord-003302-vxk7uqlc	73	15	whether	whether	IN
cord-003302-vxk7uqlc	73	16	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	73	17	imprinting	imprinting	NN
cord-003302-vxk7uqlc	73	18	is	be	VBZ
cord-003302-vxk7uqlc	73	19	helpful	helpful	JJ
cord-003302-vxk7uqlc	73	20	or	or	CC
cord-003302-vxk7uqlc	73	21	harmful	harmful	JJ
cord-003302-vxk7uqlc	73	22	for	for	IN
cord-003302-vxk7uqlc	73	23	every	every	DT
cord-003302-vxk7uqlc	73	24	individual	individual	NN
cord-003302-vxk7uqlc	73	25	is	be	VBZ
cord-003302-vxk7uqlc	73	26	still	still	RB
cord-003302-vxk7uqlc	73	27	an	an	DT
cord-003302-vxk7uqlc	73	28	open	open	JJ
cord-003302-vxk7uqlc	73	29	question	question	NN
cord-003302-vxk7uqlc	73	30	.	.	.
cord-003302-vxk7uqlc	74	1	A	a	DT
cord-003302-vxk7uqlc	74	2	similar	similar	JJ
cord-003302-vxk7uqlc	74	3	uncertainty	uncertainty	NN
cord-003302-vxk7uqlc	74	4	has	have	VBZ
cord-003302-vxk7uqlc	74	5	arisen	arise	VBN
cord-003302-vxk7uqlc	74	6	about	about	IN
cord-003302-vxk7uqlc	74	7	influenza	influenza	NN
cord-003302-vxk7uqlc	74	8	vaccination	vaccination	NN
cord-003302-vxk7uqlc	74	9	.	.	.
cord-003302-vxk7uqlc	75	1	The	the	DT
cord-003302-vxk7uqlc	75	2	doctrine	doctrine	NN
cord-003302-vxk7uqlc	75	3	of	of	IN
cord-003302-vxk7uqlc	75	4	'	'	``
cord-003302-vxk7uqlc	75	5	original	original	JJ
cord-003302-vxk7uqlc	75	6	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	75	7	sin	sin	NN
cord-003302-vxk7uqlc	75	8	'	'	''
cord-003302-vxk7uqlc	75	9	was	be	VBD
cord-003302-vxk7uqlc	75	10	developed	develop	VBN
cord-003302-vxk7uqlc	75	11	following	follow	VBG
cord-003302-vxk7uqlc	75	12	observations	observation	NNS
cord-003302-vxk7uqlc	75	13	that	that	WDT
cord-003302-vxk7uqlc	75	14	influenza	influenza	NN
cord-003302-vxk7uqlc	75	15	vaccination	vaccination	NN
cord-003302-vxk7uqlc	75	16	led	lead	VBD
cord-003302-vxk7uqlc	75	17	to	to	IN
cord-003302-vxk7uqlc	75	18	the	the	DT
cord-003302-vxk7uqlc	75	19	anamnestic	anamnestic	JJ
cord-003302-vxk7uqlc	75	20	recall	recall	NN
cord-003302-vxk7uqlc	75	21	of	of	IN
cord-003302-vxk7uqlc	75	22	antibodies	antibody	NNS
cord-003302-vxk7uqlc	75	23	to	to	IN
cord-003302-vxk7uqlc	75	24	earlier	early	JJR
cord-003302-vxk7uqlc	75	25	influenza	influenza	NN
cord-003302-vxk7uqlc	75	26	viruses	virus	NNS
cord-003302-vxk7uqlc	75	27	[	[	-LRB-
cord-003302-vxk7uqlc	75	28	15	15	CD
cord-003302-vxk7uqlc	75	29	]	]	-RRB-
cord-003302-vxk7uqlc	75	30	.	.	.
cord-003302-vxk7uqlc	76	1	Recent	recent	JJ
cord-003302-vxk7uqlc	76	2	epidemiologic	epidemiologic	JJ
cord-003302-vxk7uqlc	76	3	studies	study	NNS
cord-003302-vxk7uqlc	76	4	,	,	,
cord-003302-vxk7uqlc	76	5	however	however	RB
cord-003302-vxk7uqlc	76	6	,	,	,
cord-003302-vxk7uqlc	76	7	suggest	suggest	VBP
cord-003302-vxk7uqlc	76	8	that	that	IN
cord-003302-vxk7uqlc	76	9	repeated	repeat	VBN
cord-003302-vxk7uqlc	76	10	influenza	influenza	NN
cord-003302-vxk7uqlc	76	11	vaccinations	vaccination	NNS
cord-003302-vxk7uqlc	76	12	may	may	MD
cord-003302-vxk7uqlc	76	13	lead	lead	VB
cord-003302-vxk7uqlc	76	14	to	to	IN
cord-003302-vxk7uqlc	76	15	reduced	reduce	VBN
cord-003302-vxk7uqlc	76	16	vaccination	vaccination	NN
cord-003302-vxk7uqlc	76	17	effectiveness	effectiveness	NN
cord-003302-vxk7uqlc	76	18	[	[	-LRB-
cord-003302-vxk7uqlc	76	19	15	15	CD
cord-003302-vxk7uqlc	76	20	,	,	,
cord-003302-vxk7uqlc	76	21	23	23	CD
cord-003302-vxk7uqlc	76	22	]	]	-RRB-
cord-003302-vxk7uqlc	76	23	.	.	.
cord-003302-vxk7uqlc	77	1	Moreover	moreover	RB
cord-003302-vxk7uqlc	77	2	,	,	,
cord-003302-vxk7uqlc	77	3	repeated	repeat	VBN
cord-003302-vxk7uqlc	77	4	infection	infection	NN
cord-003302-vxk7uqlc	77	5	of	of	IN
cord-003302-vxk7uqlc	77	6	ferrets	ferret	NNS
cord-003302-vxk7uqlc	77	7	with	with	IN
cord-003302-vxk7uqlc	77	8	H3N2	H3N2	NNP
cord-003302-vxk7uqlc	77	9	viruses	virus	NNS
cord-003302-vxk7uqlc	77	10	affects	affect	VBZ
cord-003302-vxk7uqlc	77	11	both	both	CC
cord-003302-vxk7uqlc	77	12	the	the	DT
cord-003302-vxk7uqlc	77	13	quantity	quantity	NN
cord-003302-vxk7uqlc	77	14	and	and	CC
cord-003302-vxk7uqlc	77	15	quality	quality	NN
cord-003302-vxk7uqlc	77	16	of	of	IN
cord-003302-vxk7uqlc	77	17	their	-PRON-	PRP$
cord-003302-vxk7uqlc	77	18	antibody	antibody	NN
cord-003302-vxk7uqlc	77	19	responses	response	NNS
cord-003302-vxk7uqlc	77	20	[	[	-LRB-
cord-003302-vxk7uqlc	77	21	25	25	CD
cord-003302-vxk7uqlc	77	22	]	]	-RRB-
cord-003302-vxk7uqlc	77	23	.	.	.
cord-003302-vxk7uqlc	78	1	Thus	thus	RB
cord-003302-vxk7uqlc	78	2	,	,	,
cord-003302-vxk7uqlc	78	3	there	there	EX
cord-003302-vxk7uqlc	78	4	appear	appear	VBP
cord-003302-vxk7uqlc	78	5	to	to	TO
cord-003302-vxk7uqlc	78	6	be	be	VB
cord-003302-vxk7uqlc	78	7	two	two	CD
cord-003302-vxk7uqlc	78	8	sides	side	NNS
cord-003302-vxk7uqlc	78	9	to	to	IN
cord-003302-vxk7uqlc	78	10	the	the	DT
cord-003302-vxk7uqlc	78	11	host	host	NN
cord-003302-vxk7uqlc	78	12	response	response	NN
cord-003302-vxk7uqlc	78	13	following	follow	VBG
cord-003302-vxk7uqlc	78	14	repeated	repeat	VBN
cord-003302-vxk7uqlc	78	15	influenza	influenza	NN
cord-003302-vxk7uqlc	78	16	virus	virus	NN
cord-003302-vxk7uqlc	78	17	infections	infection	NNS
cord-003302-vxk7uqlc	78	18	and	and	CC
cord-003302-vxk7uqlc	78	19	vaccination	vaccination	NN
cord-003302-vxk7uqlc	78	20	.	.	.
cord-003302-vxk7uqlc	79	1	Moreover	moreover	RB
cord-003302-vxk7uqlc	79	2	,	,	,
cord-003302-vxk7uqlc	79	3	these	these	DT
cord-003302-vxk7uqlc	79	4	observations	observation	NNS
cord-003302-vxk7uqlc	79	5	leave	leave	VBP
cord-003302-vxk7uqlc	79	6	open	open	VB
cord-003302-vxk7uqlc	79	7	the	the	DT
cord-003302-vxk7uqlc	79	8	larger	large	JJR
cord-003302-vxk7uqlc	79	9	question	question	NN
cord-003302-vxk7uqlc	79	10	of	of	IN
cord-003302-vxk7uqlc	79	11	whether	whether	IN
cord-003302-vxk7uqlc	79	12	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	79	13	interaction	interaction	NN
cord-003302-vxk7uqlc	79	14	among	among	IN
cord-003302-vxk7uqlc	79	15	influenza	influenza	NN
cord-003302-vxk7uqlc	79	16	viruses	virus	NNS
cord-003302-vxk7uqlc	79	17	is	be	VBZ
cord-003302-vxk7uqlc	79	18	the	the	DT
cord-003302-vxk7uqlc	79	19	only	only	JJ
cord-003302-vxk7uqlc	79	20	determinant	determinant	NN
cord-003302-vxk7uqlc	79	21	of	of	IN
cord-003302-vxk7uqlc	79	22	how	how	WRB
cord-003302-vxk7uqlc	79	23	an	an	DT
cord-003302-vxk7uqlc	79	24	individual	individual	NN
cord-003302-vxk7uqlc	79	25	will	will	MD
cord-003302-vxk7uqlc	79	26	respond	respond	VB
cord-003302-vxk7uqlc	79	27	to	to	IN
cord-003302-vxk7uqlc	79	28	influenza	influenza	NN
cord-003302-vxk7uqlc	79	29	virus	virus	NN
cord-003302-vxk7uqlc	79	30	infection	infection	NN
cord-003302-vxk7uqlc	79	31	.	.	.
cord-003302-vxk7uqlc	80	1	Writing	write	VBG
cord-003302-vxk7uqlc	80	2	about	about	IN
cord-003302-vxk7uqlc	80	3	the	the	DT
cord-003302-vxk7uqlc	80	4	1918	1918	CD
cord-003302-vxk7uqlc	80	5	pandemic	pandemic	NN
cord-003302-vxk7uqlc	80	6	,	,	,
cord-003302-vxk7uqlc	80	7	Ahmed	Ahmed	NNP
cord-003302-vxk7uqlc	80	8	et	et	NNP
cord-003302-vxk7uqlc	80	9	al	al	NNP
cord-003302-vxk7uqlc	80	10	.	.	.
cord-003302-vxk7uqlc	81	1	observed	observe	VBD
cord-003302-vxk7uqlc	81	2	that	that	IN
cord-003302-vxk7uqlc	81	3	"	"	``
cord-003302-vxk7uqlc	81	4	children	child	NNS
cord-003302-vxk7uqlc	81	5	were	be	VBD
cord-003302-vxk7uqlc	81	6	not	not	RB
cord-003302-vxk7uqlc	81	7	protected	protect	VBN
cord-003302-vxk7uqlc	81	8	from	from	IN
cord-003302-vxk7uqlc	81	9	infection	infection	NN
cord-003302-vxk7uqlc	81	10	,	,	,
cord-003302-vxk7uqlc	81	11	but	but	CC
cord-003302-vxk7uqlc	81	12	,	,	,
cord-003302-vxk7uqlc	81	13	for	for	IN
cord-003302-vxk7uqlc	81	14	reasons	reason	NNS
cord-003302-vxk7uqlc	81	15	that	that	WDT
cord-003302-vxk7uqlc	81	16	are	be	VBP
cord-003302-vxk7uqlc	81	17	as	as	RB
cord-003302-vxk7uqlc	81	18	mysterious	mysterious	JJ
cord-003302-vxk7uqlc	81	19	today	today	NN
cord-003302-vxk7uqlc	81	20	as	as	IN
cord-003302-vxk7uqlc	81	21	they	-PRON-	PRP
cord-003302-vxk7uqlc	81	22	were	be	VBD
cord-003302-vxk7uqlc	81	23	in	in	IN
cord-003302-vxk7uqlc	81	24	1918	1918	CD
cord-003302-vxk7uqlc	81	25	,	,	,
cord-003302-vxk7uqlc	81	26	they	-PRON-	PRP
cord-003302-vxk7uqlc	81	27	were	be	VBD
cord-003302-vxk7uqlc	81	28	able	able	JJ
cord-003302-vxk7uqlc	81	29	to	to	TO
cord-003302-vxk7uqlc	81	30	cope	cope	VB
cord-003302-vxk7uqlc	81	31	with	with	IN
cord-003302-vxk7uqlc	81	32	the	the	DT
cord-003302-vxk7uqlc	81	33	disease	disease	NN
cord-003302-vxk7uqlc	81	34	much	much	RB
cord-003302-vxk7uqlc	81	35	better	well	JJR
cord-003302-vxk7uqlc	81	36	than	than	IN
cord-003302-vxk7uqlc	81	37	their	-PRON-	PRP$
cord-003302-vxk7uqlc	81	38	adult	adult	NN
cord-003302-vxk7uqlc	81	39	counterparts	counterpart	NNS
cord-003302-vxk7uqlc	81	40	"	"	''
cord-003302-vxk7uqlc	81	41	[	[	-LRB-
cord-003302-vxk7uqlc	81	42	10	10	CD
cord-003302-vxk7uqlc	81	43	]	]	-RRB-
cord-003302-vxk7uqlc	81	44	.	.	.
cord-003302-vxk7uqlc	82	1	They	-PRON-	PRP
cord-003302-vxk7uqlc	82	2	added	add	VBD
cord-003302-vxk7uqlc	82	3	,	,	,
cord-003302-vxk7uqlc	82	4	"	"	''
cord-003302-vxk7uqlc	82	5	.	.	.
cord-003302-vxk7uqlc	82	6	.	.	.
cord-003302-vxk7uqlc	82	7	.	.	.
cord-003302-vxk7uqlc	83	1	this	this	DT
cord-003302-vxk7uqlc	83	2	change	change	NN
cord-003302-vxk7uqlc	83	3	in	in	IN
cord-003302-vxk7uqlc	83	4	disease	disease	NN
cord-003302-vxk7uqlc	83	5	susceptibility	susceptibility	NN
cord-003302-vxk7uqlc	83	6	occurs	occur	VBZ
cord-003302-vxk7uqlc	83	7	around	around	IN
cord-003302-vxk7uqlc	83	8	the	the	DT
cord-003302-vxk7uqlc	83	9	time	time	NN
cord-003302-vxk7uqlc	83	10	of	of	IN
cord-003302-vxk7uqlc	83	11	puberty	puberty	NN
cord-003302-vxk7uqlc	83	12	,	,	,
cord-003302-vxk7uqlc	83	13	and	and	CC
cord-003302-vxk7uqlc	83	14	it	-PRON-	PRP
cord-003302-vxk7uqlc	83	15	is	be	VBZ
cord-003302-vxk7uqlc	83	16	possible	possible	JJ
cord-003302-vxk7uqlc	83	17	that	that	IN
cord-003302-vxk7uqlc	83	18	sex	sex	NN
cord-003302-vxk7uqlc	83	19	-	-	HYPH
cord-003302-vxk7uqlc	83	20	associated	associate	VBN
cord-003302-vxk7uqlc	83	21	hormones	hormone	NNS
cord-003302-vxk7uqlc	83	22	are	be	VBP
cord-003302-vxk7uqlc	83	23	involved	involve	VBN
cord-003302-vxk7uqlc	83	24	in	in	IN
cord-003302-vxk7uqlc	83	25	this	this	DT
cord-003302-vxk7uqlc	83	26	transition	transition	NN
cord-003302-vxk7uqlc	83	27	"	"	''
cord-003302-vxk7uqlc	83	28	[	[	-LRB-
cord-003302-vxk7uqlc	83	29	10	10	CD
cord-003302-vxk7uqlc	83	30	]	]	-RRB-
cord-003302-vxk7uqlc	83	31	.	.	.
cord-003302-vxk7uqlc	84	1	In	in	IN
cord-003302-vxk7uqlc	84	2	trying	try	VBG
cord-003302-vxk7uqlc	84	3	to	to	TO
cord-003302-vxk7uqlc	84	4	understand	understand	VB
cord-003302-vxk7uqlc	84	5	the	the	DT
cord-003302-vxk7uqlc	84	6	'	'	``
cord-003302-vxk7uqlc	84	7	mystery	mystery	NN
cord-003302-vxk7uqlc	84	8	'	'	''
cord-003302-vxk7uqlc	84	9	of	of	IN
cord-003302-vxk7uqlc	84	10	greater	great	JJR
cord-003302-vxk7uqlc	84	11	mortality	mortality	NN
cord-003302-vxk7uqlc	84	12	among	among	IN
cord-003302-vxk7uqlc	84	13	young	young	JJ
cord-003302-vxk7uqlc	84	14	adults	adult	NNS
cord-003302-vxk7uqlc	84	15	during	during	IN
cord-003302-vxk7uqlc	84	16	the	the	DT
cord-003302-vxk7uqlc	84	17	1918	1918	CD
cord-003302-vxk7uqlc	84	18	pandemic	pandemic	NN
cord-003302-vxk7uqlc	84	19	,	,	,
cord-003302-vxk7uqlc	84	20	scientists	scientist	NNS
cord-003302-vxk7uqlc	84	21	have	have	VBP
cord-003302-vxk7uqlc	84	22	studied	study	VBN
cord-003302-vxk7uqlc	84	23	influenza	influenza	NN
cord-003302-vxk7uqlc	84	24	viruses	virus	NNS
cord-003302-vxk7uqlc	84	25	and	and	CC
cord-003302-vxk7uqlc	84	26	the	the	DT
cord-003302-vxk7uqlc	84	27	human	human	JJ
cord-003302-vxk7uqlc	84	28	response	response	NN
cord-003302-vxk7uqlc	84	29	to	to	IN
cord-003302-vxk7uqlc	84	30	previous	previous	JJ
cord-003302-vxk7uqlc	84	31	infection	infection	NN
cord-003302-vxk7uqlc	84	32	.	.	.
cord-003302-vxk7uqlc	85	1	In	in	IN
cord-003302-vxk7uqlc	85	2	essence	essence	NN
cord-003302-vxk7uqlc	85	3	,	,	,
cord-003302-vxk7uqlc	85	4	they	-PRON-	PRP
cord-003302-vxk7uqlc	85	5	have	have	VBP
cord-003302-vxk7uqlc	85	6	asked	ask	VBN
cord-003302-vxk7uqlc	85	7	'	'	''
cord-003302-vxk7uqlc	85	8	why	why	WRB
cord-003302-vxk7uqlc	85	9	did	do	VBD
cord-003302-vxk7uqlc	85	10	young	young	JJ
cord-003302-vxk7uqlc	85	11	adults	adult	NNS
cord-003302-vxk7uqlc	85	12	die	die	VB
cord-003302-vxk7uqlc	85	13	?	?	.
cord-003302-vxk7uqlc	85	14	'	'	''
cord-003302-vxk7uqlc	86	1	They	-PRON-	PRP
cord-003302-vxk7uqlc	86	2	could	could	MD
cord-003302-vxk7uqlc	86	3	also	also	RB
cord-003302-vxk7uqlc	86	4	have	have	VB
cord-003302-vxk7uqlc	86	5	asked	ask	VBN
cord-003302-vxk7uqlc	86	6	'	'	''
cord-003302-vxk7uqlc	86	7	why	why	WRB
cord-003302-vxk7uqlc	86	8	did	do	VBD
cord-003302-vxk7uqlc	86	9	children	child	NNS
cord-003302-vxk7uqlc	86	10	live	live	VB
cord-003302-vxk7uqlc	86	11	?	?	.
cord-003302-vxk7uqlc	86	12	'	'	''
cord-003302-vxk7uqlc	87	1	[	[	-LRB-
cord-003302-vxk7uqlc	87	2	6	6	CD
cord-003302-vxk7uqlc	87	3	,	,	,
cord-003302-vxk7uqlc	87	4	9	9	CD
cord-003302-vxk7uqlc	87	5	,	,	,
cord-003302-vxk7uqlc	87	6	12	12	CD
cord-003302-vxk7uqlc	87	7	]	]	-RRB-
cord-003302-vxk7uqlc	87	8	.	.	.
cord-003302-vxk7uqlc	88	1	Influenza	influenza	NN
cord-003302-vxk7uqlc	88	2	scientists	scientist	NNS
cord-003302-vxk7uqlc	88	3	have	have	VBP
cord-003302-vxk7uqlc	88	4	never	never	RB
cord-003302-vxk7uqlc	88	5	created	create	VBN
cord-003302-vxk7uqlc	88	6	an	an	DT
cord-003302-vxk7uqlc	88	7	experimental	experimental	JJ
cord-003302-vxk7uqlc	88	8	model	model	NN
cord-003302-vxk7uqlc	88	9	of	of	IN
cord-003302-vxk7uqlc	88	10	the	the	DT
cord-003302-vxk7uqlc	88	11	mortality	mortality	NN
cord-003302-vxk7uqlc	88	12	experience	experience	NN
cord-003302-vxk7uqlc	88	13	seen	see	VBN
cord-003302-vxk7uqlc	88	14	in	in	IN
cord-003302-vxk7uqlc	88	15	the	the	DT
cord-003302-vxk7uqlc	88	16	1918	1918	CD
cord-003302-vxk7uqlc	88	17	.	.	.
cord-003302-vxk7uqlc	89	1	Recently	recently	RB
cord-003302-vxk7uqlc	89	2	,	,	,
cord-003302-vxk7uqlc	89	3	however	however	RB
cord-003302-vxk7uqlc	89	4	,	,	,
cord-003302-vxk7uqlc	89	5	Suber	Suber	NNP
cord-003302-vxk7uqlc	89	6	and	and	CC
cord-003302-vxk7uqlc	89	7	Kobzik	Kobzik	NNP
cord-003302-vxk7uqlc	89	8	experimentally	experimentally	RB
cord-003302-vxk7uqlc	89	9	replicated	replicate	VBD
cord-003302-vxk7uqlc	89	10	the	the	DT
cord-003302-vxk7uqlc	89	11	different	different	JJ
cord-003302-vxk7uqlc	89	12	susceptibility	susceptibility	NN
cord-003302-vxk7uqlc	89	13	of	of	IN
cord-003302-vxk7uqlc	89	14	children	child	NNS
cord-003302-vxk7uqlc	89	15	and	and	CC
cord-003302-vxk7uqlc	89	16	adults	adult	NNS
cord-003302-vxk7uqlc	89	17	to	to	IN
cord-003302-vxk7uqlc	89	18	influenza	influenza	NN
cord-003302-vxk7uqlc	89	19	-	-	HYPH
cord-003302-vxk7uqlc	89	20	related	relate	VBN
cord-003302-vxk7uqlc	89	21	mortality	mortality	NN
cord-003302-vxk7uqlc	89	22	[	[	-LRB-
cord-003302-vxk7uqlc	89	23	26	26	CD
cord-003302-vxk7uqlc	89	24	]	]	-RRB-
cord-003302-vxk7uqlc	89	25	.	.	.
cord-003302-vxk7uqlc	90	1	They	-PRON-	PRP
cord-003302-vxk7uqlc	90	2	infected	infect	VBD
cord-003302-vxk7uqlc	90	3	groups	group	NNS
cord-003302-vxk7uqlc	90	4	of	of	IN
cord-003302-vxk7uqlc	90	5	C57BL/6	C57BL/6	NNP
cord-003302-vxk7uqlc	90	6	mice	mouse	NNS
cord-003302-vxk7uqlc	90	7	with	with	IN
cord-003302-vxk7uqlc	90	8	influenza	influenza	NN
cord-003302-vxk7uqlc	90	9	A(H1N1	a(h1n1	CD
cord-003302-vxk7uqlc	90	10	)	)	-RRB-
cord-003302-vxk7uqlc	91	1	(	(	-LRB-
cord-003302-vxk7uqlc	91	2	PR8	PR8	NNP
cord-003302-vxk7uqlc	91	3	)	)	-RRB-
cord-003302-vxk7uqlc	91	4	virus	virus	NN
cord-003302-vxk7uqlc	91	5	.	.	.
cord-003302-vxk7uqlc	92	1	Male	male	JJ
cord-003302-vxk7uqlc	92	2	and	and	CC
cord-003302-vxk7uqlc	92	3	female	female	JJ
cord-003302-vxk7uqlc	92	4	mice	mouse	NNS
cord-003302-vxk7uqlc	92	5	were	be	VBD
cord-003302-vxk7uqlc	92	6	infected	infect	VBN
cord-003302-vxk7uqlc	92	7	on	on	IN
cord-003302-vxk7uqlc	92	8	either	either	DT
cord-003302-vxk7uqlc	92	9	postnatal	postnatal	JJ
cord-003302-vxk7uqlc	92	10	day	day	NN
cord-003302-vxk7uqlc	92	11	25	25	CD
cord-003302-vxk7uqlc	92	12	(	(	-LRB-
cord-003302-vxk7uqlc	92	13	P25	P25	NNP
cord-003302-vxk7uqlc	92	14	,	,	,
cord-003302-vxk7uqlc	92	15	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	92	16	)	)	-RRB-
cord-003302-vxk7uqlc	92	17	or	or	CC
cord-003302-vxk7uqlc	92	18	postnatal	postnatal	JJ
cord-003302-vxk7uqlc	92	19	day	day	NN
cord-003302-vxk7uqlc	92	20	28	28	CD
cord-003302-vxk7uqlc	93	1	(	(	-LRB-
cord-003302-vxk7uqlc	93	2	P28	P28	NNP
cord-003302-vxk7uqlc	93	3	,	,	,
cord-003302-vxk7uqlc	93	4	pubertal	pubertal	JJ
cord-003302-vxk7uqlc	93	5	)	)	-RRB-
cord-003302-vxk7uqlc	93	6	.	.	.
cord-003302-vxk7uqlc	94	1	(	(	-LRB-
cord-003302-vxk7uqlc	94	2	In	in	IN
cord-003302-vxk7uqlc	94	3	C57BL/6	C57BL/6	NNP
cord-003302-vxk7uqlc	94	4	mice	mouse	NNS
cord-003302-vxk7uqlc	94	5	,	,	,
cord-003302-vxk7uqlc	94	6	puberty	puberty	NN
cord-003302-vxk7uqlc	94	7	usually	usually	RB
cord-003302-vxk7uqlc	94	8	starts	start	VBZ
cord-003302-vxk7uqlc	94	9	on	on	IN
cord-003302-vxk7uqlc	94	10	postnatal	postnatal	JJ
cord-003302-vxk7uqlc	94	11	day	day	NN
cord-003302-vxk7uqlc	94	12	P27	P27	NNP
cord-003302-vxk7uqlc	94	13	or	or	CC
cord-003302-vxk7uqlc	94	14	P28	P28	NNP
cord-003302-vxk7uqlc	94	15	.	.	.
cord-003302-vxk7uqlc	94	16	)	)	-RRB-
cord-003302-vxk7uqlc	95	1	Mortality	mortality	NN
cord-003302-vxk7uqlc	95	2	was	be	VBD
cord-003302-vxk7uqlc	95	3	much	much	RB
cord-003302-vxk7uqlc	95	4	greater	great	JJR
cord-003302-vxk7uqlc	95	5	in	in	IN
cord-003302-vxk7uqlc	95	6	pubertal	pubertal	JJ
cord-003302-vxk7uqlc	95	7	(	(	-LRB-
cord-003302-vxk7uqlc	95	8	P28	P28	NNP
cord-003302-vxk7uqlc	95	9	)	)	-RRB-
cord-003302-vxk7uqlc	95	10	than	than	IN
cord-003302-vxk7uqlc	95	11	in	in	IN
cord-003302-vxk7uqlc	95	12	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	95	13	(	(	-LRB-
cord-003302-vxk7uqlc	95	14	P25	P25	NNP
cord-003302-vxk7uqlc	95	15	)	)	-RRB-
cord-003302-vxk7uqlc	95	16	mice	mouse	NNS
cord-003302-vxk7uqlc	95	17	(	(	-LRB-
cord-003302-vxk7uqlc	95	18	Fig	Fig	NNP
cord-003302-vxk7uqlc	95	19	.	.	.
cord-003302-vxk7uqlc	95	20	2a	2a	CD
cord-003302-vxk7uqlc	95	21	and	and	CC
cord-003302-vxk7uqlc	95	22	b	b	LS
cord-003302-vxk7uqlc	95	23	)	)	-RRB-
cord-003302-vxk7uqlc	95	24	.	.	.
cord-003302-vxk7uqlc	96	1	Deaths	death	NNS
cord-003302-vxk7uqlc	96	2	began	begin	VBD
cord-003302-vxk7uqlc	96	3	to	to	TO
cord-003302-vxk7uqlc	96	4	occur	occur	VB
cord-003302-vxk7uqlc	96	5	9	9	CD
cord-003302-vxk7uqlc	96	6	days	day	NNS
cord-003302-vxk7uqlc	96	7	following	follow	VBG
cord-003302-vxk7uqlc	96	8	infection	infection	NN
cord-003302-vxk7uqlc	96	9	.	.	.
cord-003302-vxk7uqlc	97	1	By	by	IN
cord-003302-vxk7uqlc	97	2	this	this	DT
cord-003302-vxk7uqlc	97	3	time	time	NN
cord-003302-vxk7uqlc	97	4	,	,	,
cord-003302-vxk7uqlc	97	5	pulmonary	pulmonary	JJ
cord-003302-vxk7uqlc	97	6	virus	virus	NN
cord-003302-vxk7uqlc	97	7	titers	titer	NNS
cord-003302-vxk7uqlc	97	8	had	have	VBD
cord-003302-vxk7uqlc	97	9	fallen	fall	VBN
cord-003302-vxk7uqlc	97	10	to	to	IN
cord-003302-vxk7uqlc	97	11	levels	level	NNS
cord-003302-vxk7uqlc	97	12	much	much	RB
cord-003302-vxk7uqlc	97	13	lower	low	JJR
cord-003302-vxk7uqlc	97	14	than	than	IN
cord-003302-vxk7uqlc	97	15	they	-PRON-	PRP
cord-003302-vxk7uqlc	97	16	were	be	VBD
cord-003302-vxk7uqlc	97	17	on	on	IN
cord-003302-vxk7uqlc	97	18	days	day	NNS
cord-003302-vxk7uqlc	97	19	3	3	CD
cord-003302-vxk7uqlc	97	20	and	and	CC
cord-003302-vxk7uqlc	97	21	6	6	CD
cord-003302-vxk7uqlc	97	22	,	,	,
cord-003302-vxk7uqlc	97	23	and	and	CC
cord-003302-vxk7uqlc	97	24	they	-PRON-	PRP
cord-003302-vxk7uqlc	97	25	were	be	VBD
cord-003302-vxk7uqlc	97	26	similar	similar	JJ
cord-003302-vxk7uqlc	97	27	in	in	IN
cord-003302-vxk7uqlc	97	28	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	97	29	and	and	CC
cord-003302-vxk7uqlc	97	30	pubertal	pubertal	JJ
cord-003302-vxk7uqlc	97	31	mice	mouse	NNS
cord-003302-vxk7uqlc	98	1	(	(	-LRB-
cord-003302-vxk7uqlc	98	2	Fig	Fig	NNP
cord-003302-vxk7uqlc	98	3	.	.	.
cord-003302-vxk7uqlc	98	4	2c	2c	NNP
cord-003302-vxk7uqlc	98	5	)	)	-RRB-
cord-003302-vxk7uqlc	98	6	.	.	.
cord-003302-vxk7uqlc	99	1	High	high	JJ
cord-003302-vxk7uqlc	99	2	-	-	HYPH
cord-003302-vxk7uqlc	99	3	dose	dose	NN
cord-003302-vxk7uqlc	99	4	,	,	,
cord-003302-vxk7uqlc	99	5	exogenous	exogenous	JJ
cord-003302-vxk7uqlc	99	6	estrogen	estrogen	NN
cord-003302-vxk7uqlc	99	7	treatment	treatment	NN
cord-003302-vxk7uqlc	99	8	is	be	VBZ
cord-003302-vxk7uqlc	99	9	known	know	VBN
cord-003302-vxk7uqlc	99	10	to	to	TO
cord-003302-vxk7uqlc	99	11	protect	protect	VB
cord-003302-vxk7uqlc	99	12	adult	adult	NN
cord-003302-vxk7uqlc	99	13	female	female	JJ
cord-003302-vxk7uqlc	99	14	mice	mouse	NNS
cord-003302-vxk7uqlc	99	15	infected	infect	VBN
cord-003302-vxk7uqlc	99	16	with	with	IN
cord-003302-vxk7uqlc	99	17	influenza	influenza	NN
cord-003302-vxk7uqlc	99	18	virus	virus	NN
cord-003302-vxk7uqlc	99	19	[	[	-LRB-
cord-003302-vxk7uqlc	99	20	27	27	CD
cord-003302-vxk7uqlc	99	21	]	]	-RRB-
cord-003302-vxk7uqlc	99	22	.	.	.
cord-003302-vxk7uqlc	100	1	To	to	TO
cord-003302-vxk7uqlc	100	2	determine	determine	VB
cord-003302-vxk7uqlc	100	3	the	the	DT
cord-003302-vxk7uqlc	100	4	role	role	NN
cord-003302-vxk7uqlc	100	5	of	of	IN
cord-003302-vxk7uqlc	100	6	sex	sex	NN
cord-003302-vxk7uqlc	100	7	hormones	hormone	NNS
cord-003302-vxk7uqlc	100	8	in	in	IN
cord-003302-vxk7uqlc	100	9	the	the	DT
cord-003302-vxk7uqlc	100	10	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	100	11	/	/	SYM
cord-003302-vxk7uqlc	100	12	pubertal	pubertal	JJ
cord-003302-vxk7uqlc	100	13	mortality	mortality	NN
cord-003302-vxk7uqlc	101	1	Differences	difference	NNS
cord-003302-vxk7uqlc	101	2	between	between	IN
cord-003302-vxk7uqlc	101	3	P25	P25	NNP
cord-003302-vxk7uqlc	101	4	and	and	CC
cord-003302-vxk7uqlc	101	5	P28	P28	NNP
cord-003302-vxk7uqlc	101	6	mice	mouse	NNS
cord-003302-vxk7uqlc	101	7	were	be	VBD
cord-003302-vxk7uqlc	101	8	not	not	RB
cord-003302-vxk7uqlc	101	9	significant	significant	JJ
cord-003302-vxk7uqlc	101	10	by	by	IN
cord-003302-vxk7uqlc	101	11	the	the	DT
cord-003302-vxk7uqlc	101	12	Kruskal	Kruskal	NNP
cord-003302-vxk7uqlc	101	13	-	-	HYPH
cord-003302-vxk7uqlc	101	14	Wallis	Wallis	NNP
cord-003302-vxk7uqlc	101	15	with	with	IN
cord-003302-vxk7uqlc	101	16	Dunn	Dunn	NNP
cord-003302-vxk7uqlc	101	17	's	's	POS
cord-003302-vxk7uqlc	101	18	multiple	multiple	JJ
cord-003302-vxk7uqlc	101	19	comparisons	comparison	NNS
cord-003302-vxk7uqlc	101	20	test	test	VBP
cord-003302-vxk7uqlc	101	21	.	.	.
cord-003302-vxk7uqlc	102	1	From	from	IN
cord-003302-vxk7uqlc	102	2	Ref	Ref	NNP
cord-003302-vxk7uqlc	102	3	.	.	.
cord-003302-vxk7uqlc	103	1	[	[	-LRB-
cord-003302-vxk7uqlc	103	2	26	26	CD
cord-003302-vxk7uqlc	103	3	]	]	-RRB-
cord-003302-vxk7uqlc	103	4	with	with	IN
cord-003302-vxk7uqlc	103	5	permission	permission	NN
cord-003302-vxk7uqlc	103	6	difference	difference	NN
cord-003302-vxk7uqlc	103	7	,	,	,
cord-003302-vxk7uqlc	103	8	Suber	Suber	NNP
cord-003302-vxk7uqlc	103	9	and	and	CC
cord-003302-vxk7uqlc	103	10	Kobzik	Kobzik	NNP
cord-003302-vxk7uqlc	103	11	castrated	castrate	VBD
cord-003302-vxk7uqlc	103	12	male	male	JJ
cord-003302-vxk7uqlc	103	13	and	and	CC
cord-003302-vxk7uqlc	103	14	female	female	JJ
cord-003302-vxk7uqlc	103	15	mice	mouse	NNS
cord-003302-vxk7uqlc	103	16	on	on	IN
cord-003302-vxk7uqlc	103	17	day	day	NN
cord-003302-vxk7uqlc	103	18	P21	P21	NNP
cord-003302-vxk7uqlc	103	19	and	and	CC
cord-003302-vxk7uqlc	103	20	infected	infect	VBD
cord-003302-vxk7uqlc	103	21	them	-PRON-	PRP
cord-003302-vxk7uqlc	103	22	on	on	IN
cord-003302-vxk7uqlc	103	23	day	day	NN
cord-003302-vxk7uqlc	103	24	P28	P28	NNP
cord-003302-vxk7uqlc	103	25	[	[	-LRB-
cord-003302-vxk7uqlc	103	26	26	26	CD
cord-003302-vxk7uqlc	103	27	]	]	-RRB-
cord-003302-vxk7uqlc	103	28	.	.	.
cord-003302-vxk7uqlc	104	1	Over	over	IN
cord-003302-vxk7uqlc	104	2	the	the	DT
cord-003302-vxk7uqlc	104	3	next	next	JJ
cord-003302-vxk7uqlc	104	4	3	3	CD
cord-003302-vxk7uqlc	104	5	weeks	week	NNS
cord-003302-vxk7uqlc	104	6	,	,	,
cord-003302-vxk7uqlc	104	7	mortality	mortality	NN
cord-003302-vxk7uqlc	104	8	was	be	VBD
cord-003302-vxk7uqlc	104	9	reduced	reduce	VBN
cord-003302-vxk7uqlc	104	10	in	in	IN
cord-003302-vxk7uqlc	104	11	castrated	castrate	VBN
cord-003302-vxk7uqlc	104	12	but	but	CC
cord-003302-vxk7uqlc	104	13	not	not	RB
cord-003302-vxk7uqlc	104	14	in	in	IN
cord-003302-vxk7uqlc	104	15	sham	sham	NN
cord-003302-vxk7uqlc	104	16	-	-	HYPH
cord-003302-vxk7uqlc	104	17	operated	operate	VBN
cord-003302-vxk7uqlc	104	18	mice	mouse	NNS
cord-003302-vxk7uqlc	104	19	.	.	.
cord-003302-vxk7uqlc	105	1	They	-PRON-	PRP
cord-003302-vxk7uqlc	105	2	then	then	RB
cord-003302-vxk7uqlc	105	3	blocked	block	VBD
cord-003302-vxk7uqlc	105	4	the	the	DT
cord-003302-vxk7uqlc	105	5	onset	onset	NN
cord-003302-vxk7uqlc	105	6	of	of	IN
cord-003302-vxk7uqlc	105	7	puberty	puberty	NN
cord-003302-vxk7uqlc	105	8	in	in	IN
cord-003302-vxk7uqlc	105	9	P28-infected	p28-infected	JJ
cord-003302-vxk7uqlc	105	10	female	female	JJ
cord-003302-vxk7uqlc	105	11	mice	mouse	NNS
cord-003302-vxk7uqlc	105	12	by	by	IN
cord-003302-vxk7uqlc	105	13	pretreating	pretreate	VBG
cord-003302-vxk7uqlc	105	14	them	-PRON-	PRP
cord-003302-vxk7uqlc	105	15	(	(	-LRB-
cord-003302-vxk7uqlc	105	16	starting	start	VBG
cord-003302-vxk7uqlc	105	17	on	on	IN
cord-003302-vxk7uqlc	105	18	day	day	NN
cord-003302-vxk7uqlc	105	19	P21	P21	NNP
cord-003302-vxk7uqlc	105	20	)	)	-RRB-
cord-003302-vxk7uqlc	105	21	with	with	IN
cord-003302-vxk7uqlc	105	22	leuprolide	leuprolide	NN
cord-003302-vxk7uqlc	105	23	,	,	,
cord-003302-vxk7uqlc	105	24	a	a	DT
cord-003302-vxk7uqlc	105	25	gonadotropin	gonadotropin	NN
cord-003302-vxk7uqlc	105	26	-	-	HYPH
cord-003302-vxk7uqlc	105	27	releasing	release	VBG
cord-003302-vxk7uqlc	105	28	hormone	hormone	NN
cord-003302-vxk7uqlc	105	29	(	(	-LRB-
cord-003302-vxk7uqlc	105	30	GnRH	GnRH	NNP
cord-003302-vxk7uqlc	105	31	)	)	-RRB-
cord-003302-vxk7uqlc	105	32	analog	analog	NN
cord-003302-vxk7uqlc	105	33	.	.	.
cord-003302-vxk7uqlc	106	1	Leuprolide	Leuprolide	NNP
cord-003302-vxk7uqlc	106	2	desensitizes	desensitize	VBZ
cord-003302-vxk7uqlc	106	3	GnRH	gnrh	JJ
cord-003302-vxk7uqlc	106	4	receptors	receptor	NNS
cord-003302-vxk7uqlc	106	5	and	and	CC
cord-003302-vxk7uqlc	106	6	decreases	decrease	VBZ
cord-003302-vxk7uqlc	106	7	the	the	DT
cord-003302-vxk7uqlc	106	8	secretion	secretion	NN
cord-003302-vxk7uqlc	106	9	of	of	IN
cord-003302-vxk7uqlc	106	10	gonadotropins	gonadotropin	NNS
cord-003302-vxk7uqlc	106	11	,	,	,
cord-003302-vxk7uqlc	106	12	and	and	CC
cord-003302-vxk7uqlc	106	13	this	this	DT
cord-003302-vxk7uqlc	106	14	blocks	block	VBZ
cord-003302-vxk7uqlc	106	15	the	the	DT
cord-003302-vxk7uqlc	106	16	normal	normal	JJ
cord-003302-vxk7uqlc	106	17	pubertal	pubertal	JJ
cord-003302-vxk7uqlc	106	18	increase	increase	NN
cord-003302-vxk7uqlc	106	19	in	in	IN
cord-003302-vxk7uqlc	106	20	estrogen	estrogen	NN
cord-003302-vxk7uqlc	106	21	.	.	.
cord-003302-vxk7uqlc	107	1	They	-PRON-	PRP
cord-003302-vxk7uqlc	107	2	also	also	RB
cord-003302-vxk7uqlc	107	3	pretreated	pretreate	VBD
cord-003302-vxk7uqlc	107	4	male	male	JJ
cord-003302-vxk7uqlc	107	5	and	and	CC
cord-003302-vxk7uqlc	107	6	female	female	JJ
cord-003302-vxk7uqlc	107	7	P28infected	p28infected	JJ
cord-003302-vxk7uqlc	107	8	mice	mouse	NNS
cord-003302-vxk7uqlc	107	9	with	with	IN
cord-003302-vxk7uqlc	107	10	acyline	acyline	NNP
cord-003302-vxk7uqlc	107	11	,	,	,
cord-003302-vxk7uqlc	107	12	a	a	DT
cord-003302-vxk7uqlc	107	13	GnRH	GnRH	NNP
cord-003302-vxk7uqlc	107	14	antagonist	antagonist	NN
cord-003302-vxk7uqlc	107	15	.	.	.
cord-003302-vxk7uqlc	108	1	Both	both	DT
cord-003302-vxk7uqlc	108	2	leuprolide	leuprolide	NN
cord-003302-vxk7uqlc	108	3	and	and	CC
cord-003302-vxk7uqlc	108	4	acyline	acyline	NN
cord-003302-vxk7uqlc	108	5	pretreatment	pretreatment	NN
cord-003302-vxk7uqlc	108	6	improved	improve	VBD
cord-003302-vxk7uqlc	108	7	survival	survival	NN
cord-003302-vxk7uqlc	108	8	[	[	-LRB-
cord-003302-vxk7uqlc	108	9	26	26	CD
cord-003302-vxk7uqlc	108	10	]	]	-RRB-
cord-003302-vxk7uqlc	108	11	.	.	.
cord-003302-vxk7uqlc	109	1	In	in	IN
cord-003302-vxk7uqlc	109	2	addition	addition	NN
cord-003302-vxk7uqlc	109	3	,	,	,
cord-003302-vxk7uqlc	109	4	when	when	WRB
cord-003302-vxk7uqlc	109	5	P21-ovariectomized	p21-ovariectomized	JJ
cord-003302-vxk7uqlc	109	6	mice	mouse	NNS
cord-003302-vxk7uqlc	109	7	were	be	VBD
cord-003302-vxk7uqlc	109	8	infected	infect	VBN
cord-003302-vxk7uqlc	109	9	on	on	IN
cord-003302-vxk7uqlc	109	10	day	day	NN
cord-003302-vxk7uqlc	109	11	P28	P28	NNP
cord-003302-vxk7uqlc	109	12	,	,	,
cord-003302-vxk7uqlc	109	13	estrogen	estrogen	NN
cord-003302-vxk7uqlc	109	14	treatment	treatment	NN
cord-003302-vxk7uqlc	109	15	given	give	VBN
cord-003302-vxk7uqlc	109	16	0	0	CD
cord-003302-vxk7uqlc	109	17	-	-	SYM
cord-003302-vxk7uqlc	109	18	2	2	CD
cord-003302-vxk7uqlc	109	19	or	or	CC
cord-003302-vxk7uqlc	109	20	6	6	CD
cord-003302-vxk7uqlc	109	21	-	-	SYM
cord-003302-vxk7uqlc	109	22	8	8	CD
cord-003302-vxk7uqlc	109	23	days	day	NNS
cord-003302-vxk7uqlc	109	24	following	follow	VBG
cord-003302-vxk7uqlc	109	25	infection	infection	NN
cord-003302-vxk7uqlc	109	26	abrogated	abrogate	VBD
cord-003302-vxk7uqlc	109	27	the	the	DT
cord-003302-vxk7uqlc	109	28	protective	protective	JJ
cord-003302-vxk7uqlc	109	29	effect	effect	NN
cord-003302-vxk7uqlc	109	30	of	of	IN
cord-003302-vxk7uqlc	109	31	ovariectomy	ovariectomy	NN
cord-003302-vxk7uqlc	109	32	.	.	.
cord-003302-vxk7uqlc	110	1	Protection	protection	NN
cord-003302-vxk7uqlc	110	2	was	be	VBD
cord-003302-vxk7uqlc	110	3	also	also	RB
cord-003302-vxk7uqlc	110	4	reversed	reverse	VBN
cord-003302-vxk7uqlc	110	5	in	in	IN
cord-003302-vxk7uqlc	110	6	castrated	castrate	VBN
cord-003302-vxk7uqlc	110	7	males	male	NNS
cord-003302-vxk7uqlc	110	8	by	by	IN
cord-003302-vxk7uqlc	110	9	treatment	treatment	NN
cord-003302-vxk7uqlc	110	10	with	with	IN
cord-003302-vxk7uqlc	110	11	both	both	CC
cord-003302-vxk7uqlc	110	12	estrogen	estrogen	NN
cord-003302-vxk7uqlc	110	13	and	and	CC
cord-003302-vxk7uqlc	110	14	testosterone	testosterone	NN
cord-003302-vxk7uqlc	110	15	(	(	-LRB-
cord-003302-vxk7uqlc	110	16	normally	normally	RB
cord-003302-vxk7uqlc	110	17	,	,	,
cord-003302-vxk7uqlc	110	18	testosterone	testosterone	NN
cord-003302-vxk7uqlc	110	19	is	be	VBZ
cord-003302-vxk7uqlc	110	20	converted	convert	VBN
cord-003302-vxk7uqlc	110	21	to	to	IN
cord-003302-vxk7uqlc	110	22	estrogen	estrogen	NN
cord-003302-vxk7uqlc	110	23	by	by	IN
cord-003302-vxk7uqlc	110	24	aromatase	aromatase	NN
cord-003302-vxk7uqlc	110	25	)	)	-RRB-
cord-003302-vxk7uqlc	110	26	.	.	.
cord-003302-vxk7uqlc	111	1	Transcriptome	Transcriptome	NNP
cord-003302-vxk7uqlc	111	2	profiling	profile	VBG
cord-003302-vxk7uqlc	111	3	over	over	IN
cord-003302-vxk7uqlc	111	4	the	the	DT
cord-003302-vxk7uqlc	111	5	course	course	NN
cord-003302-vxk7uqlc	111	6	of	of	IN
cord-003302-vxk7uqlc	111	7	infection	infection	NN
cord-003302-vxk7uqlc	111	8	showed	show	VBD
cord-003302-vxk7uqlc	111	9	marked	mark	VBN
cord-003302-vxk7uqlc	111	10	enrichment	enrichment	NN
cord-003302-vxk7uqlc	111	11	of	of	IN
cord-003302-vxk7uqlc	111	12	estrogen	estrogen	NN
cord-003302-vxk7uqlc	111	13	,	,	,
cord-003302-vxk7uqlc	111	14	b	b	NN
cord-003302-vxk7uqlc	111	15	-	-	HYPH
cord-003302-vxk7uqlc	111	16	estradiol	estradiol	NN
cord-003302-vxk7uqlc	111	17	and	and	CC
cord-003302-vxk7uqlc	111	18	estrogen	estrogen	NN
cord-003302-vxk7uqlc	111	19	receptor	receptor	NN
cord-003302-vxk7uqlc	111	20	1	1	CD
cord-003302-vxk7uqlc	111	21	[	[	-LRB-
cord-003302-vxk7uqlc	111	22	26	26	CD
cord-003302-vxk7uqlc	111	23	]	]	-RRB-
cord-003302-vxk7uqlc	111	24	.	.	.
cord-003302-vxk7uqlc	112	1	For	for	IN
cord-003302-vxk7uqlc	112	2	this	this	DT
cord-003302-vxk7uqlc	112	3	reason	reason	NN
cord-003302-vxk7uqlc	112	4	,	,	,
cord-003302-vxk7uqlc	112	5	estrogen	estrogen	NN
cord-003302-vxk7uqlc	112	6	receptor	receptor	NN
cord-003302-vxk7uqlc	112	7	blockade	blockade	NN
cord-003302-vxk7uqlc	112	8	was	be	VBD
cord-003302-vxk7uqlc	112	9	carried	carry	VBN
cord-003302-vxk7uqlc	112	10	out	out	RP
cord-003302-vxk7uqlc	112	11	using	use	VBG
cord-003302-vxk7uqlc	112	12	fulvestrant	fulvestrant	NN
cord-003302-vxk7uqlc	112	13	.	.	.
cord-003302-vxk7uqlc	113	1	Pretreating	Pretreating	NNP
cord-003302-vxk7uqlc	113	2	P28-infected	P28-infected	NNP
cord-003302-vxk7uqlc	113	3	male	male	JJ
cord-003302-vxk7uqlc	113	4	and	and	CC
cord-003302-vxk7uqlc	113	5	female	female	JJ
cord-003302-vxk7uqlc	113	6	mice	mouse	NNS
cord-003302-vxk7uqlc	113	7	reduced	reduce	VBD
cord-003302-vxk7uqlc	113	8	subsequent	subsequent	JJ
cord-003302-vxk7uqlc	113	9	mortality	mortality	NN
cord-003302-vxk7uqlc	113	10	,	,	,
cord-003302-vxk7uqlc	113	11	and	and	CC
cord-003302-vxk7uqlc	113	12	when	when	WRB
cord-003302-vxk7uqlc	113	13	fulvestrant	fulvestrant	NN
cord-003302-vxk7uqlc	113	14	was	be	VBD
cord-003302-vxk7uqlc	113	15	given	give	VBN
cord-003302-vxk7uqlc	113	16	to	to	IN
cord-003302-vxk7uqlc	113	17	females	female	NNS
cord-003302-vxk7uqlc	113	18	3	3	CD
cord-003302-vxk7uqlc	113	19	days	day	NNS
cord-003302-vxk7uqlc	113	20	following	follow	VBG
cord-003302-vxk7uqlc	113	21	infection	infection	NN
cord-003302-vxk7uqlc	113	22	,	,	,
cord-003302-vxk7uqlc	113	23	survival	survival	NN
cord-003302-vxk7uqlc	113	24	was	be	VBD
cord-003302-vxk7uqlc	113	25	greatly	greatly	RB
cord-003302-vxk7uqlc	113	26	improved	improve	VBN
cord-003302-vxk7uqlc	113	27	.	.	.
cord-003302-vxk7uqlc	114	1	In	in	IN
cord-003302-vxk7uqlc	114	2	addition	addition	NN
cord-003302-vxk7uqlc	114	3	,	,	,
cord-003302-vxk7uqlc	114	4	in	in	IN
cord-003302-vxk7uqlc	114	5	older	old	JJR
cord-003302-vxk7uqlc	114	6	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	114	7	male	male	JJ
cord-003302-vxk7uqlc	114	8	and	and	CC
cord-003302-vxk7uqlc	114	9	female	female	JJ
cord-003302-vxk7uqlc	114	10	mice	mouse	NNS
cord-003302-vxk7uqlc	114	11	infected	infect	VBN
cord-003302-vxk7uqlc	114	12	on	on	IN
cord-003302-vxk7uqlc	114	13	day	day	NN
cord-003302-vxk7uqlc	114	14	P42	P42	NNP
cord-003302-vxk7uqlc	114	15	,	,	,
cord-003302-vxk7uqlc	114	16	survival	survival	NN
cord-003302-vxk7uqlc	114	17	also	also	RB
cord-003302-vxk7uqlc	114	18	improved	improve	VBD
cord-003302-vxk7uqlc	114	19	when	when	WRB
cord-003302-vxk7uqlc	114	20	fulvestrant	fulvestrant	JJ
cord-003302-vxk7uqlc	114	21	treatment	treatment	NN
cord-003302-vxk7uqlc	114	22	was	be	VBD
cord-003302-vxk7uqlc	114	23	started	start	VBN
cord-003302-vxk7uqlc	114	24	3	3	CD
cord-003302-vxk7uqlc	114	25	days	day	NNS
cord-003302-vxk7uqlc	114	26	following	follow	VBG
cord-003302-vxk7uqlc	114	27	infection	infection	NN
cord-003302-vxk7uqlc	114	28	[	[	-LRB-
cord-003302-vxk7uqlc	114	29	26	26	CD
cord-003302-vxk7uqlc	114	30	]	]	-RRB-
cord-003302-vxk7uqlc	114	31	.	.	.
cord-003302-vxk7uqlc	115	1	Transcriptome	Transcriptome	NNP
cord-003302-vxk7uqlc	115	2	analysis	analysis	NN
cord-003302-vxk7uqlc	115	3	also	also	RB
cord-003302-vxk7uqlc	115	4	showed	show	VBD
cord-003302-vxk7uqlc	115	5	increased	increased	JJ
cord-003302-vxk7uqlc	115	6	expression	expression	NN
cord-003302-vxk7uqlc	115	7	of	of	IN
cord-003302-vxk7uqlc	115	8	IL-1b	IL-1b	NNS
cord-003302-vxk7uqlc	115	9	in	in	IN
cord-003302-vxk7uqlc	115	10	the	the	DT
cord-003302-vxk7uqlc	115	11	lungs	lung	NNS
cord-003302-vxk7uqlc	115	12	and	and	CC
cord-003302-vxk7uqlc	115	13	blood	blood	NN
cord-003302-vxk7uqlc	115	14	leukocytes	leukocyte	NNS
cord-003302-vxk7uqlc	115	15	of	of	IN
cord-003302-vxk7uqlc	115	16	pubertal	pubertal	JJ
cord-003302-vxk7uqlc	115	17	(	(	-LRB-
cord-003302-vxk7uqlc	115	18	P28	P28	NNP
cord-003302-vxk7uqlc	115	19	)	)	-RRB-
cord-003302-vxk7uqlc	115	20	mice	mouse	NNS
cord-003302-vxk7uqlc	115	21	9	9	CD
cord-003302-vxk7uqlc	115	22	days	day	NNS
cord-003302-vxk7uqlc	115	23	after	after	IN
cord-003302-vxk7uqlc	115	24	infection	infection	NN
cord-003302-vxk7uqlc	115	25	[	[	-LRB-
cord-003302-vxk7uqlc	115	26	26	26	CD
cord-003302-vxk7uqlc	115	27	]	]	-RRB-
cord-003302-vxk7uqlc	115	28	.	.	.
cord-003302-vxk7uqlc	116	1	When	when	WRB
cord-003302-vxk7uqlc	116	2	pubertal	pubertal	JJ
cord-003302-vxk7uqlc	116	3	mice	mouse	NNS
cord-003302-vxk7uqlc	116	4	were	be	VBD
cord-003302-vxk7uqlc	116	5	infected	infect	VBN
cord-003302-vxk7uqlc	116	6	on	on	IN
cord-003302-vxk7uqlc	116	7	day	day	NN
cord-003302-vxk7uqlc	116	8	P28	P28	NNP
cord-003302-vxk7uqlc	116	9	and	and	CC
cord-003302-vxk7uqlc	116	10	then	then	RB
cord-003302-vxk7uqlc	116	11	treated	treat	VBN
cord-003302-vxk7uqlc	116	12	with	with	IN
cord-003302-vxk7uqlc	116	13	anti	anti	NNS
cord-003302-vxk7uqlc	116	14	-	-	JJ
cord-003302-vxk7uqlc	116	15	IL-1b	il-1b	JJ
cord-003302-vxk7uqlc	116	16	blocking	block	VBG
cord-003302-vxk7uqlc	116	17	antibody	antibody	NN
cord-003302-vxk7uqlc	116	18	5	5	CD
cord-003302-vxk7uqlc	116	19	and	and	CC
cord-003302-vxk7uqlc	116	20	9	9	CD
cord-003302-vxk7uqlc	116	21	days	day	NNS
cord-003302-vxk7uqlc	116	22	later	later	RB
cord-003302-vxk7uqlc	116	23	,	,	,
cord-003302-vxk7uqlc	116	24	survival	survival	NN
cord-003302-vxk7uqlc	116	25	was	be	VBD
cord-003302-vxk7uqlc	116	26	greatly	greatly	RB
cord-003302-vxk7uqlc	116	27	improved	improve	VBN
cord-003302-vxk7uqlc	116	28	.	.	.
cord-003302-vxk7uqlc	117	1	Early	early	JJ
cord-003302-vxk7uqlc	117	2	treatment	treatment	NN
cord-003302-vxk7uqlc	117	3	on	on	IN
cord-003302-vxk7uqlc	117	4	the	the	DT
cord-003302-vxk7uqlc	117	5	day	day	NN
cord-003302-vxk7uqlc	117	6	of	of	IN
cord-003302-vxk7uqlc	117	7	infection	infection	NN
cord-003302-vxk7uqlc	117	8	,	,	,
cord-003302-vxk7uqlc	117	9	however	however	RB
cord-003302-vxk7uqlc	117	10	,	,	,
cord-003302-vxk7uqlc	117	11	was	be	VBD
cord-003302-vxk7uqlc	117	12	not	not	RB
cord-003302-vxk7uqlc	117	13	beneficial	beneficial	JJ
cord-003302-vxk7uqlc	117	14	,	,	,
cord-003302-vxk7uqlc	117	15	suggesting	suggest	VBG
cord-003302-vxk7uqlc	117	16	that	that	IN
cord-003302-vxk7uqlc	117	17	IL-1b	IL-1b	NNP
cord-003302-vxk7uqlc	117	18	activity	activity	NN
cord-003302-vxk7uqlc	117	19	was	be	VBD
cord-003302-vxk7uqlc	117	20	expressed	express	VBN
cord-003302-vxk7uqlc	117	21	differently	differently	RB
cord-003302-vxk7uqlc	117	22	at	at	IN
cord-003302-vxk7uqlc	117	23	different	different	JJ
cord-003302-vxk7uqlc	117	24	stages	stage	NNS
cord-003302-vxk7uqlc	117	25	of	of	IN
cord-003302-vxk7uqlc	117	26	disease	disease	NN
cord-003302-vxk7uqlc	117	27	[	[	-LRB-
cord-003302-vxk7uqlc	117	28	26	26	CD
cord-003302-vxk7uqlc	117	29	]	]	-RRB-
cord-003302-vxk7uqlc	117	30	.	.	.
cord-003302-vxk7uqlc	118	1	As	as	IN
cord-003302-vxk7uqlc	118	2	discussed	discuss	VBN
cord-003302-vxk7uqlc	118	3	above	above	IN
cord-003302-vxk7uqlc	118	4	mortality	mortality	NN
cord-003302-vxk7uqlc	118	5	rates	rate	NNS
cord-003302-vxk7uqlc	118	6	in	in	IN
cord-003302-vxk7uqlc	118	7	many	many	JJ
cord-003302-vxk7uqlc	118	8	infectious	infectious	JJ
cord-003302-vxk7uqlc	118	9	diseases	disease	NNS
cord-003302-vxk7uqlc	118	10	are	be	VBP
cord-003302-vxk7uqlc	118	11	lower	low	JJR
cord-003302-vxk7uqlc	118	12	in	in	IN
cord-003302-vxk7uqlc	118	13	children	child	NNS
cord-003302-vxk7uqlc	118	14	than	than	IN
cord-003302-vxk7uqlc	118	15	they	-PRON-	PRP
cord-003302-vxk7uqlc	118	16	are	be	VBP
cord-003302-vxk7uqlc	118	17	in	in	IN
cord-003302-vxk7uqlc	118	18	adults	adult	NNS
cord-003302-vxk7uqlc	118	19	[	[	-LRB-
cord-003302-vxk7uqlc	118	20	6	6	CD
cord-003302-vxk7uqlc	118	21	,	,	,
cord-003302-vxk7uqlc	118	22	10	10	CD
cord-003302-vxk7uqlc	118	23	]	]	-RRB-
cord-003302-vxk7uqlc	118	24	,	,	.
cord-003302-vxk7uqlc	118	25	For	for	IN
cord-003302-vxk7uqlc	118	26	this	this	DT
cord-003302-vxk7uqlc	118	27	reason	reason	NN
cord-003302-vxk7uqlc	118	28	,	,	,
cord-003302-vxk7uqlc	118	29	Joachim	Joachim	NNP
cord-003302-vxk7uqlc	118	30	and	and	CC
cord-003302-vxk7uqlc	118	31	Kobzik	Kobzik	NNP
cord-003302-vxk7uqlc	118	32	studied	study	VBD
cord-003302-vxk7uqlc	118	33	mice	mouse	NNS
cord-003302-vxk7uqlc	118	34	with	with	IN
cord-003302-vxk7uqlc	118	35	endotoxin	endotoxin	NN
cord-003302-vxk7uqlc	118	36	(	(	-LRB-
cord-003302-vxk7uqlc	118	37	LPS)-induced	lps)-induced	JJ
cord-003302-vxk7uqlc	118	38	sepsis	sepsis	NN
cord-003302-vxk7uqlc	118	39	before	before	IN
cord-003302-vxk7uqlc	118	40	and	and	CC
cord-003302-vxk7uqlc	118	41	after	after	IN
cord-003302-vxk7uqlc	118	42	puberty	puberty	NN
cord-003302-vxk7uqlc	118	43	[	[	-LRB-
cord-003302-vxk7uqlc	118	44	28	28	CD
cord-003302-vxk7uqlc	118	45	]	]	-RRB-
cord-003302-vxk7uqlc	118	46	.	.	.
cord-003302-vxk7uqlc	119	1	The	the	DT
cord-003302-vxk7uqlc	119	2	conditions	condition	NNS
cord-003302-vxk7uqlc	119	3	for	for	IN
cord-003302-vxk7uqlc	119	4	these	these	DT
cord-003302-vxk7uqlc	119	5	experiments	experiment	NNS
cord-003302-vxk7uqlc	119	6	differed	differ	VBD
cord-003302-vxk7uqlc	119	7	slightly	slightly	RB
cord-003302-vxk7uqlc	119	8	from	from	IN
cord-003302-vxk7uqlc	119	9	those	those	DT
cord-003302-vxk7uqlc	119	10	in	in	IN
cord-003302-vxk7uqlc	119	11	the	the	DT
cord-003302-vxk7uqlc	119	12	influenza	influenza	NN
cord-003302-vxk7uqlc	119	13	experiments	experiment	NNS
cord-003302-vxk7uqlc	119	14	[	[	-LRB-
cord-003302-vxk7uqlc	119	15	26	26	CD
cord-003302-vxk7uqlc	119	16	]	]	-RRB-
cord-003302-vxk7uqlc	119	17	;	;	:
cord-003302-vxk7uqlc	119	18	all	all	DT
cord-003302-vxk7uqlc	119	19	mice	mouse	NNS
cord-003302-vxk7uqlc	119	20	were	be	VBD
cord-003302-vxk7uqlc	119	21	female	female	JJ
cord-003302-vxk7uqlc	119	22	and	and	CC
cord-003302-vxk7uqlc	119	23	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	119	24	mice	mouse	NNS
cord-003302-vxk7uqlc	119	25	were	be	VBD
cord-003302-vxk7uqlc	119	26	given	give	VBN
cord-003302-vxk7uqlc	119	27	LPS	LPS	NNP
cord-003302-vxk7uqlc	119	28	on	on	IN
cord-003302-vxk7uqlc	119	29	postnatal	postnatal	JJ
cord-003302-vxk7uqlc	119	30	days	day	NNS
cord-003302-vxk7uqlc	119	31	33	33	CD
cord-003302-vxk7uqlc	119	32	-	-	SYM
cord-003302-vxk7uqlc	119	33	35	35	CD
cord-003302-vxk7uqlc	119	34	,	,	,
cord-003302-vxk7uqlc	119	35	not	not	RB
cord-003302-vxk7uqlc	119	36	earlier	early	RBR
cord-003302-vxk7uqlc	119	37	.	.	.
cord-003302-vxk7uqlc	120	1	Prepubertal	Prepubertal	NNP
cord-003302-vxk7uqlc	120	2	mice	mouse	NNS
cord-003302-vxk7uqlc	120	3	injected	inject	VBD
cord-003302-vxk7uqlc	120	4	intraperitoneally	intraperitoneally	RB
cord-003302-vxk7uqlc	120	5	with	with	IN
cord-003302-vxk7uqlc	120	6	LPS	LPS	NNP
cord-003302-vxk7uqlc	120	7	on	on	IN
cord-003302-vxk7uqlc	120	8	day	day	NN
cord-003302-vxk7uqlc	121	1	P24	p24	NN
cord-003302-vxk7uqlc	121	2	-	-	HYPH
cord-003302-vxk7uqlc	121	3	26	26	CD
cord-003302-vxk7uqlc	121	4	had	have	VBD
cord-003302-vxk7uqlc	121	5	significantly	significantly	RB
cord-003302-vxk7uqlc	121	6	better	well	JJR
cord-003302-vxk7uqlc	121	7	survival	survival	NN
cord-003302-vxk7uqlc	121	8	than	than	IN
cord-003302-vxk7uqlc	121	9	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	121	10	mice	mouse	NNS
cord-003302-vxk7uqlc	121	11	20	20	CD
cord-003302-vxk7uqlc	121	12	h	h	NN
cord-003302-vxk7uqlc	121	13	after	after	IN
cord-003302-vxk7uqlc	121	14	injection	injection	NN
cord-003302-vxk7uqlc	122	1	(	(	-LRB-
cord-003302-vxk7uqlc	122	2	Fig	Fig	NNP
cord-003302-vxk7uqlc	122	3	.	.	.
cord-003302-vxk7uqlc	122	4	 	 	_SP
cord-003302-vxk7uqlc	122	5	3a	3a	NNP
cord-003302-vxk7uqlc	122	6	)	)	-RRB-
cord-003302-vxk7uqlc	122	7	,	,	,
cord-003302-vxk7uqlc	122	8	although	although	IN
cord-003302-vxk7uqlc	122	9	endotoxin	endotoxin	NN
cord-003302-vxk7uqlc	122	10	levels	level	NNS
cord-003302-vxk7uqlc	122	11	in	in	IN
cord-003302-vxk7uqlc	122	12	the	the	DT
cord-003302-vxk7uqlc	122	13	blood	blood	NN
cord-003302-vxk7uqlc	122	14	were	be	VBD
cord-003302-vxk7uqlc	122	15	similar	similar	JJ
cord-003302-vxk7uqlc	122	16	in	in	IN
cord-003302-vxk7uqlc	122	17	both	both	DT
cord-003302-vxk7uqlc	122	18	groups	group	NNS
cord-003302-vxk7uqlc	122	19	(	(	-LRB-
cord-003302-vxk7uqlc	122	20	Fig	Fig	NNP
cord-003302-vxk7uqlc	122	21	.	.	.
cord-003302-vxk7uqlc	122	22	3b	3b	CD
cord-003302-vxk7uqlc	122	23	)	)	-RRB-
cord-003302-vxk7uqlc	123	1	[	[	-LRB-
cord-003302-vxk7uqlc	123	2	28	28	CD
cord-003302-vxk7uqlc	123	3	]	]	-RRB-
cord-003302-vxk7uqlc	123	4	.	.	.
cord-003302-vxk7uqlc	124	1	As	as	IN
cord-003302-vxk7uqlc	124	2	in	in	IN
cord-003302-vxk7uqlc	124	3	the	the	DT
cord-003302-vxk7uqlc	124	4	influenza	influenza	NN
cord-003302-vxk7uqlc	124	5	experiments	experiment	NNS
cord-003302-vxk7uqlc	124	6	,	,	,
cord-003302-vxk7uqlc	124	7	survival	survival	NN
cord-003302-vxk7uqlc	124	8	in	in	IN
cord-003302-vxk7uqlc	124	9	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	124	10	mice	mouse	NNS
cord-003302-vxk7uqlc	124	11	improved	improve	VBD
cord-003302-vxk7uqlc	124	12	when	when	WRB
cord-003302-vxk7uqlc	124	13	the	the	DT
cord-003302-vxk7uqlc	124	14	onset	onset	NN
cord-003302-vxk7uqlc	124	15	of	of	IN
cord-003302-vxk7uqlc	124	16	puberty	puberty	NN
cord-003302-vxk7uqlc	124	17	was	be	VBD
cord-003302-vxk7uqlc	124	18	delayed	delay	VBN
cord-003302-vxk7uqlc	124	19	by	by	IN
cord-003302-vxk7uqlc	124	20	pretreatment	pretreatment	NN
cord-003302-vxk7uqlc	124	21	with	with	IN
cord-003302-vxk7uqlc	124	22	estrogen	estrogen	NN
cord-003302-vxk7uqlc	124	23	(	(	-LRB-
cord-003302-vxk7uqlc	124	24	3	3	CD
cord-003302-vxk7uqlc	124	25	days	day	NNS
cord-003302-vxk7uqlc	124	26	before	before	RB
cord-003302-vxk7uqlc	124	27	and	and	CC
cord-003302-vxk7uqlc	124	28	on	on	IN
cord-003302-vxk7uqlc	124	29	the	the	DT
cord-003302-vxk7uqlc	124	30	day	day	NN
cord-003302-vxk7uqlc	124	31	of	of	IN
cord-003302-vxk7uqlc	124	32	LPS	LPS	NNP
cord-003302-vxk7uqlc	124	33	injection	injection	NN
cord-003302-vxk7uqlc	124	34	)	)	-RRB-
cord-003302-vxk7uqlc	124	35	.	.	.
cord-003302-vxk7uqlc	125	1	Similarly	similarly	RB
cord-003302-vxk7uqlc	125	2	,	,	,
cord-003302-vxk7uqlc	125	3	in	in	IN
cord-003302-vxk7uqlc	125	4	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	125	5	mice	mouse	NNS
cord-003302-vxk7uqlc	125	6	injected	inject	VBN
cord-003302-vxk7uqlc	125	7	with	with	IN
cord-003302-vxk7uqlc	125	8	LPS	LPS	NNP
cord-003302-vxk7uqlc	125	9	,	,	,
cord-003302-vxk7uqlc	125	10	blocking	block	VBG
cord-003302-vxk7uqlc	125	11	the	the	DT
cord-003302-vxk7uqlc	125	12	onset	onset	NN
cord-003302-vxk7uqlc	125	13	of	of	IN
cord-003302-vxk7uqlc	125	14	puberty	puberty	NN
cord-003302-vxk7uqlc	125	15	by	by	IN
cord-003302-vxk7uqlc	125	16	pretreatment	pretreatment	NN
cord-003302-vxk7uqlc	125	17	with	with	IN
cord-003302-vxk7uqlc	125	18	leuprolide	leuprolide	NN
cord-003302-vxk7uqlc	125	19	(	(	-LRB-
cord-003302-vxk7uqlc	125	20	administered	administer	VBN
cord-003302-vxk7uqlc	125	21	daily	daily	RB
cord-003302-vxk7uqlc	125	22	from	from	IN
cord-003302-vxk7uqlc	125	23	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	125	24	day	day	NN
cord-003302-vxk7uqlc	125	25	P24	P24	NNP
cord-003302-vxk7uqlc	125	26	to	to	IN
cord-003302-vxk7uqlc	125	27	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	125	28	day	day	NN
cord-003302-vxk7uqlc	125	29	P35	P35	NNP
cord-003302-vxk7uqlc	125	30	)	)	-RRB-
cord-003302-vxk7uqlc	125	31	substantially	substantially	RB
cord-003302-vxk7uqlc	125	32	improved	improve	VBN
cord-003302-vxk7uqlc	125	33	survival	survival	NN
cord-003302-vxk7uqlc	125	34	.	.	.
cord-003302-vxk7uqlc	126	1	In	in	IN
cord-003302-vxk7uqlc	126	2	addition	addition	NN
cord-003302-vxk7uqlc	126	3	,	,	,
cord-003302-vxk7uqlc	126	4	fulvestrant	fulvestrant	NN
cord-003302-vxk7uqlc	126	5	was	be	VBD
cord-003302-vxk7uqlc	126	6	administered	administer	VBN
cord-003302-vxk7uqlc	126	7	to	to	TO
cord-003302-vxk7uqlc	126	8	pre	pre	VB
cord-003302-vxk7uqlc	126	9	-	-	VB
cord-003302-vxk7uqlc	126	10	and	and	CC
cord-003302-vxk7uqlc	126	11	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	126	12	mice	mouse	NNS
cord-003302-vxk7uqlc	126	13	to	to	TO
cord-003302-vxk7uqlc	126	14	determine	determine	VB
cord-003302-vxk7uqlc	126	15	whether	whether	IN
cord-003302-vxk7uqlc	126	16	the	the	DT
cord-003302-vxk7uqlc	126	17	increase	increase	NN
cord-003302-vxk7uqlc	126	18	in	in	IN
cord-003302-vxk7uqlc	126	19	LPS	LPS	NNP
cord-003302-vxk7uqlc	126	20	-	-	HYPH
cord-003302-vxk7uqlc	126	21	induced	induce	VBN
cord-003302-vxk7uqlc	126	22	mortality	mortality	NN
cord-003302-vxk7uqlc	126	23	was	be	VBD
cord-003302-vxk7uqlc	126	24	specifically	specifically	RB
cord-003302-vxk7uqlc	126	25	due	due	JJ
cord-003302-vxk7uqlc	126	26	to	to	IN
cord-003302-vxk7uqlc	126	27	the	the	DT
cord-003302-vxk7uqlc	126	28	onset	onset	NN
cord-003302-vxk7uqlc	126	29	of	of	IN
cord-003302-vxk7uqlc	126	30	puberty	puberty	NN
cord-003302-vxk7uqlc	126	31	or	or	CC
cord-003302-vxk7uqlc	126	32	the	the	DT
cord-003302-vxk7uqlc	126	33	lack	lack	NN
cord-003302-vxk7uqlc	126	34	of	of	IN
cord-003302-vxk7uqlc	126	35	estrogen	estrogen	NN
cord-003302-vxk7uqlc	126	36	activity	activity	NN
cord-003302-vxk7uqlc	126	37	,	,	,
cord-003302-vxk7uqlc	126	38	but	but	CC
cord-003302-vxk7uqlc	126	39	the	the	DT
cord-003302-vxk7uqlc	126	40	results	result	NNS
cord-003302-vxk7uqlc	126	41	were	be	VBD
cord-003302-vxk7uqlc	126	42	indeterminate	indeterminate	JJ
cord-003302-vxk7uqlc	126	43	.	.	.
cord-003302-vxk7uqlc	127	1	Finally	finally	RB
cord-003302-vxk7uqlc	127	2	,	,	,
cord-003302-vxk7uqlc	127	3	in	in	IN
cord-003302-vxk7uqlc	127	4	LPS	LPS	NNP
cord-003302-vxk7uqlc	127	5	-	-	HYPH
cord-003302-vxk7uqlc	127	6	treated	treat	VBN
cord-003302-vxk7uqlc	127	7	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	127	8	mice	mouse	NNS
cord-003302-vxk7uqlc	127	9	,	,	,
cord-003302-vxk7uqlc	127	10	adoptive	adoptive	JJ
cord-003302-vxk7uqlc	127	11	transfer	transfer	NN
cord-003302-vxk7uqlc	127	12	of	of	IN
cord-003302-vxk7uqlc	127	13	peritoneal	peritoneal	JJ
cord-003302-vxk7uqlc	127	14	cells	cell	NNS
cord-003302-vxk7uqlc	127	15	(	(	-LRB-
cord-003302-vxk7uqlc	127	16	macrophages	macrophage	NNS
cord-003302-vxk7uqlc	127	17	and	and	CC
cord-003302-vxk7uqlc	127	18	B	b	NN
cord-003302-vxk7uqlc	127	19	and	and	CC
cord-003302-vxk7uqlc	127	20	T	t	NN
cord-003302-vxk7uqlc	127	21	cells	cell	NNS
cord-003302-vxk7uqlc	127	22	)	)	-RRB-
cord-003302-vxk7uqlc	127	23	harvested	harvest	VBN
cord-003302-vxk7uqlc	127	24	from	from	IN
cord-003302-vxk7uqlc	127	25	LPS	LPS	NNP
cord-003302-vxk7uqlc	127	26	-	-	HYPH
cord-003302-vxk7uqlc	127	27	naive	naive	JJ
cord-003302-vxk7uqlc	127	28	pre	pre	JJ
cord-003302-vxk7uqlc	127	29	-	-	JJ
cord-003302-vxk7uqlc	127	30	and	and	CC
cord-003302-vxk7uqlc	127	31	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	127	32	mice	mouse	NNS
cord-003302-vxk7uqlc	127	33	had	have	VBD
cord-003302-vxk7uqlc	127	34	different	different	JJ
cord-003302-vxk7uqlc	127	35	effects	effect	NNS
cord-003302-vxk7uqlc	127	36	on	on	IN
cord-003302-vxk7uqlc	127	37	survival	survival	NN
cord-003302-vxk7uqlc	127	38	:	:	:
cord-003302-vxk7uqlc	127	39	mice	mouse	NNS
cord-003302-vxk7uqlc	127	40	that	that	WDT
cord-003302-vxk7uqlc	127	41	received	receive	VBD
cord-003302-vxk7uqlc	127	42	cells	cell	NNS
cord-003302-vxk7uqlc	127	43	from	from	IN
cord-003302-vxk7uqlc	127	44	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	127	45	mice	mouse	NNS
cord-003302-vxk7uqlc	127	46	had	have	VBD
cord-003302-vxk7uqlc	127	47	significantly	significantly	RB
cord-003302-vxk7uqlc	127	48	lower	low	JJR
cord-003302-vxk7uqlc	127	49	mortality	mortality	NN
cord-003302-vxk7uqlc	127	50	than	than	IN
cord-003302-vxk7uqlc	127	51	those	those	DT
cord-003302-vxk7uqlc	127	52	treated	treat	VBN
cord-003302-vxk7uqlc	127	53	with	with	IN
cord-003302-vxk7uqlc	127	54	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	127	55	cells	cell	NNS
cord-003302-vxk7uqlc	127	56	(	(	-LRB-
cord-003302-vxk7uqlc	127	57	Fig	Fig	NNP
cord-003302-vxk7uqlc	127	58	.	.	.
cord-003302-vxk7uqlc	127	59	3c	3c	NNP
cord-003302-vxk7uqlc	127	60	)	)	-RRB-
cord-003302-vxk7uqlc	128	1	[	[	-LRB-
cord-003302-vxk7uqlc	128	2	28	28	CD
cord-003302-vxk7uqlc	128	3	]	]	-RRB-
cord-003302-vxk7uqlc	128	4	.	.	.
cord-003302-vxk7uqlc	129	1	Investigators	investigator	NNS
cord-003302-vxk7uqlc	129	2	have	have	VBP
cord-003302-vxk7uqlc	129	3	presented	present	VBN
cord-003302-vxk7uqlc	129	4	many	many	JJ
cord-003302-vxk7uqlc	129	5	arguments	argument	NNS
cord-003302-vxk7uqlc	129	6	for	for	IN
cord-003302-vxk7uqlc	129	7	and	and	CC
cord-003302-vxk7uqlc	129	8	against	against	IN
cord-003302-vxk7uqlc	129	9	the	the	DT
cord-003302-vxk7uqlc	129	10	use	use	NN
cord-003302-vxk7uqlc	129	11	of	of	IN
cord-003302-vxk7uqlc	129	12	murine	murine	JJ
cord-003302-vxk7uqlc	129	13	models	model	NNS
cord-003302-vxk7uqlc	129	14	to	to	TO
cord-003302-vxk7uqlc	129	15	explain	explain	VB
cord-003302-vxk7uqlc	129	16	aspects	aspect	NNS
cord-003302-vxk7uqlc	129	17	of	of	IN
cord-003302-vxk7uqlc	129	18	acute	acute	JJ
cord-003302-vxk7uqlc	129	19	critical	critical	JJ
cord-003302-vxk7uqlc	129	20	illness	illness	NN
cord-003302-vxk7uqlc	129	21	in	in	IN
cord-003302-vxk7uqlc	129	22	humans	human	NNS
cord-003302-vxk7uqlc	129	23	[	[	-LRB-
cord-003302-vxk7uqlc	129	24	29	29	CD
cord-003302-vxk7uqlc	129	25	,	,	,
cord-003302-vxk7uqlc	129	26	30	30	CD
cord-003302-vxk7uqlc	129	27	]	]	-RRB-
cord-003302-vxk7uqlc	129	28	.	.	.
cord-003302-vxk7uqlc	130	1	For	for	IN
cord-003302-vxk7uqlc	130	2	comparative	comparative	JJ
cord-003302-vxk7uqlc	130	3	studies	study	NNS
cord-003302-vxk7uqlc	130	4	of	of	IN
cord-003302-vxk7uqlc	130	5	puberty	puberty	NN
cord-003302-vxk7uqlc	130	6	,	,	,
cord-003302-vxk7uqlc	130	7	mice	mouse	NNS
cord-003302-vxk7uqlc	130	8	present	present	JJ
cord-003302-vxk7uqlc	130	9	special	special	JJ
cord-003302-vxk7uqlc	130	10	problems	problem	NNS
cord-003302-vxk7uqlc	130	11	;	;	:
cord-003302-vxk7uqlc	130	12	humans	human	NNS
cord-003302-vxk7uqlc	130	13	live	live	VBP
cord-003302-vxk7uqlc	130	14	much	much	RB
cord-003302-vxk7uqlc	130	15	longer	long	RBR
cord-003302-vxk7uqlc	130	16	than	than	IN
cord-003302-vxk7uqlc	130	17	mice	mouse	NNS
cord-003302-vxk7uqlc	130	18	and	and	CC
cord-003302-vxk7uqlc	130	19	human	human	JJ
cord-003302-vxk7uqlc	130	20	puberty	puberty	NN
cord-003302-vxk7uqlc	130	21	extends	extend	VBZ
cord-003302-vxk7uqlc	130	22	over	over	IN
cord-003302-vxk7uqlc	130	23	several	several	JJ
cord-003302-vxk7uqlc	130	24	years	year	NNS
cord-003302-vxk7uqlc	130	25	,	,	,
cord-003302-vxk7uqlc	130	26	not	not	RB
cord-003302-vxk7uqlc	130	27	a	a	DT
cord-003302-vxk7uqlc	130	28	day	day	NN
cord-003302-vxk7uqlc	130	29	or	or	CC
cord-003302-vxk7uqlc	130	30	two	two	CD
cord-003302-vxk7uqlc	130	31	as	as	IN
cord-003302-vxk7uqlc	130	32	in	in	IN
cord-003302-vxk7uqlc	130	33	mice	mouse	NNS
cord-003302-vxk7uqlc	130	34	.	.	.
cord-003302-vxk7uqlc	131	1	Nonetheless	nonetheless	RB
cord-003302-vxk7uqlc	131	2	,	,	,
cord-003302-vxk7uqlc	131	3	murine	murine	JJ
cord-003302-vxk7uqlc	131	4	studies	study	NNS
cord-003302-vxk7uqlc	131	5	before	before	IN
cord-003302-vxk7uqlc	131	6	and	and	CC
cord-003302-vxk7uqlc	131	7	after	after	IN
cord-003302-vxk7uqlc	131	8	puberty	puberty	NN
cord-003302-vxk7uqlc	131	9	can	can	MD
cord-003302-vxk7uqlc	131	10	be	be	VB
cord-003302-vxk7uqlc	131	11	of	of	IN
cord-003302-vxk7uqlc	131	12	considerable	considerable	JJ
cord-003302-vxk7uqlc	131	13	value	value	NN
cord-003302-vxk7uqlc	131	14	.	.	.
cord-003302-vxk7uqlc	132	1	For	for	IN
cord-003302-vxk7uqlc	132	2	example	example	NN
cord-003302-vxk7uqlc	132	3	,	,	,
cord-003302-vxk7uqlc	132	4	estrogens	estrogen	NNS
cord-003302-vxk7uqlc	132	5	have	have	VBP
cord-003302-vxk7uqlc	132	6	an	an	DT
cord-003302-vxk7uqlc	132	7	mice	mouse	NNS
cord-003302-vxk7uqlc	132	8	were	be	VBD
cord-003302-vxk7uqlc	132	9	injected	inject	VBN
cord-003302-vxk7uqlc	132	10	intraperitoneally	intraperitoneally	RB
cord-003302-vxk7uqlc	132	11	with	with	IN
cord-003302-vxk7uqlc	132	12	LPS	LPS	NNP
cord-003302-vxk7uqlc	132	13	(	(	-LRB-
cord-003302-vxk7uqlc	132	14	Salmonella	Salmonella	NNP
cord-003302-vxk7uqlc	132	15	enterica	enterica	NN
cord-003302-vxk7uqlc	132	16	)	)	-RRB-
cord-003302-vxk7uqlc	132	17	and	and	CC
cord-003302-vxk7uqlc	132	18	followed	follow	VBD
cord-003302-vxk7uqlc	132	19	for	for	IN
cord-003302-vxk7uqlc	132	20	5	5	CD
cord-003302-vxk7uqlc	132	21	days	day	NNS
cord-003302-vxk7uqlc	132	22	.	.	.
cord-003302-vxk7uqlc	133	1	Mortality	mortality	NN
cord-003302-vxk7uqlc	133	2	in	in	IN
cord-003302-vxk7uqlc	133	3	mice	mouse	NNS
cord-003302-vxk7uqlc	133	4	injected	inject	VBN
cord-003302-vxk7uqlc	133	5	with	with	IN
cord-003302-vxk7uqlc	133	6	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	133	7	peritoneal	peritoneal	JJ
cord-003302-vxk7uqlc	133	8	cells	cell	NNS
cord-003302-vxk7uqlc	133	9	was	be	VBD
cord-003302-vxk7uqlc	133	10	significantly	significantly	RB
cord-003302-vxk7uqlc	133	11	lower	low	JJR
cord-003302-vxk7uqlc	133	12	than	than	IN
cord-003302-vxk7uqlc	133	13	it	-PRON-	PRP
cord-003302-vxk7uqlc	133	14	was	be	VBD
cord-003302-vxk7uqlc	133	15	in	in	IN
cord-003302-vxk7uqlc	133	16	control	control	NN
cord-003302-vxk7uqlc	133	17	mice	mouse	NNS
cord-003302-vxk7uqlc	133	18	or	or	CC
cord-003302-vxk7uqlc	133	19	those	those	DT
cord-003302-vxk7uqlc	133	20	that	that	WDT
cord-003302-vxk7uqlc	133	21	received	receive	VBD
cord-003302-vxk7uqlc	133	22	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	133	23	peritoneal	peritoneal	JJ
cord-003302-vxk7uqlc	133	24	cells	cell	NNS
cord-003302-vxk7uqlc	133	25	.	.	.
cord-003302-vxk7uqlc	134	1	From	from	IN
cord-003302-vxk7uqlc	134	2	Ref	Ref	NNP
cord-003302-vxk7uqlc	134	3	.	.	.
cord-003302-vxk7uqlc	135	1	[	[	-LRB-
cord-003302-vxk7uqlc	135	2	28	28	CD
cord-003302-vxk7uqlc	135	3	]	]	-RRB-
cord-003302-vxk7uqlc	135	4	with	with	IN
cord-003302-vxk7uqlc	135	5	permission	permission	NN
cord-003302-vxk7uqlc	135	6	important	important	JJ
cord-003302-vxk7uqlc	135	7	role	role	NN
cord-003302-vxk7uqlc	135	8	in	in	IN
cord-003302-vxk7uqlc	135	9	puberty	puberty	NN
cord-003302-vxk7uqlc	136	1	and	and	CC
cord-003302-vxk7uqlc	136	2	they	-PRON-	PRP
cord-003302-vxk7uqlc	136	3	can	can	MD
cord-003302-vxk7uqlc	136	4	also	also	RB
cord-003302-vxk7uqlc	136	5	modify	modify	VB
cord-003302-vxk7uqlc	136	6	the	the	DT
cord-003302-vxk7uqlc	136	7	response	response	NN
cord-003302-vxk7uqlc	136	8	to	to	TO
cord-003302-vxk7uqlc	136	9	acute	acute	VB
cord-003302-vxk7uqlc	136	10	critical	critical	JJ
cord-003302-vxk7uqlc	136	11	illness	illness	NN
cord-003302-vxk7uqlc	136	12	.	.	.
cord-003302-vxk7uqlc	137	1	Kobzik	Kobzik	NNP
cord-003302-vxk7uqlc	137	2	et	et	NNP
cord-003302-vxk7uqlc	137	3	al	al	NNP
cord-003302-vxk7uqlc	137	4	.	.	NNP
cord-003302-vxk7uqlc	137	5	have	have	VBP
cord-003302-vxk7uqlc	137	6	shown	show	VBN
cord-003302-vxk7uqlc	137	7	that	that	IN
cord-003302-vxk7uqlc	137	8	unlike	unlike	IN
cord-003302-vxk7uqlc	137	9	other	other	JJ
cord-003302-vxk7uqlc	137	10	studies	study	NNS
cord-003302-vxk7uqlc	137	11	,	,	,
cord-003302-vxk7uqlc	137	12	estrogen	estrogen	NN
cord-003302-vxk7uqlc	137	13	treatment	treatment	NN
cord-003302-vxk7uqlc	137	14	reversed	reverse	VBD
cord-003302-vxk7uqlc	137	15	protection	protection	NN
cord-003302-vxk7uqlc	137	16	against	against	IN
cord-003302-vxk7uqlc	137	17	influenza	influenza	NN
cord-003302-vxk7uqlc	137	18	mortality	mortality	NN
cord-003302-vxk7uqlc	137	19	in	in	IN
cord-003302-vxk7uqlc	137	20	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	137	21	and	and	CC
cord-003302-vxk7uqlc	137	22	castrated	castrated	JJ
cord-003302-vxk7uqlc	137	23	mice	mouse	NNS
cord-003302-vxk7uqlc	137	24	[	[	-LRB-
cord-003302-vxk7uqlc	137	25	26	26	CD
cord-003302-vxk7uqlc	137	26	]	]	-RRB-
cord-003302-vxk7uqlc	137	27	.	.	.
cord-003302-vxk7uqlc	138	1	These	these	DT
cord-003302-vxk7uqlc	138	2	apparently	apparently	RB
cord-003302-vxk7uqlc	138	3	contradictory	contradictory	JJ
cord-003302-vxk7uqlc	138	4	findings	finding	NNS
cord-003302-vxk7uqlc	138	5	might	may	MD
cord-003302-vxk7uqlc	138	6	reflect	reflect	VB
cord-003302-vxk7uqlc	138	7	the	the	DT
cord-003302-vxk7uqlc	138	8	known	know	VBN
cord-003302-vxk7uqlc	138	9	pro	pro	JJ
cord-003302-vxk7uqlc	138	10	-	-	JJ
cord-003302-vxk7uqlc	138	11	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	138	12	activities	activity	NNS
cord-003302-vxk7uqlc	138	13	of	of	IN
cord-003302-vxk7uqlc	138	14	low	low	JJ
cord-003302-vxk7uqlc	138	15	-	-	HYPH
cord-003302-vxk7uqlc	138	16	dose	dose	NN
cord-003302-vxk7uqlc	138	17	estrogens	estrogen	NNS
cord-003302-vxk7uqlc	138	18	and	and	CC
cord-003302-vxk7uqlc	138	19	their	-PRON-	PRP$
cord-003302-vxk7uqlc	138	20	anti	anti	JJ
cord-003302-vxk7uqlc	138	21	-	-	JJ
cord-003302-vxk7uqlc	138	22	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	138	23	effects	effect	NNS
cord-003302-vxk7uqlc	138	24	when	when	WRB
cord-003302-vxk7uqlc	138	25	higher	high	JJR
cord-003302-vxk7uqlc	138	26	doses	dose	NNS
cord-003302-vxk7uqlc	138	27	are	be	VBP
cord-003302-vxk7uqlc	138	28	used	use	VBN
cord-003302-vxk7uqlc	138	29	[	[	-LRB-
cord-003302-vxk7uqlc	138	30	26	26	CD
cord-003302-vxk7uqlc	138	31	,	,	,
cord-003302-vxk7uqlc	138	32	27	27	CD
cord-003302-vxk7uqlc	138	33	]	]	-RRB-
cord-003302-vxk7uqlc	138	34	.	.	.
cord-003302-vxk7uqlc	139	1	Suber	Suber	NNP
cord-003302-vxk7uqlc	139	2	and	and	CC
cord-003302-vxk7uqlc	139	3	Kobzik	Kobzik	NNP
cord-003302-vxk7uqlc	139	4	have	have	VBP
cord-003302-vxk7uqlc	139	5	shown	show	VBN
cord-003302-vxk7uqlc	139	6	that	that	IN
cord-003302-vxk7uqlc	139	7	the	the	DT
cord-003302-vxk7uqlc	139	8	different	different	JJ
cord-003302-vxk7uqlc	139	9	influenza	influenza	NN
cord-003302-vxk7uqlc	139	10	mortality	mortality	NN
cord-003302-vxk7uqlc	139	11	rates	rate	NNS
cord-003302-vxk7uqlc	139	12	in	in	IN
cord-003302-vxk7uqlc	139	13	pre	pre	JJ
cord-003302-vxk7uqlc	139	14	-	-	JJ
cord-003302-vxk7uqlc	139	15	and	and	CC
cord-003302-vxk7uqlc	139	16	postpubertal	postpubertal	JJ
cord-003302-vxk7uqlc	139	17	mice	mouse	NNS
cord-003302-vxk7uqlc	139	18	have	have	VBP
cord-003302-vxk7uqlc	139	19	nothing	nothing	NN
cord-003302-vxk7uqlc	139	20	to	to	TO
cord-003302-vxk7uqlc	139	21	do	do	VB
cord-003302-vxk7uqlc	139	22	with	with	IN
cord-003302-vxk7uqlc	139	23	previous	previous	JJ
cord-003302-vxk7uqlc	139	24	exposure	exposure	NN
cord-003302-vxk7uqlc	139	25	to	to	IN
cord-003302-vxk7uqlc	139	26	influenza	influenza	NN
cord-003302-vxk7uqlc	139	27	viruses	virus	NNS
cord-003302-vxk7uqlc	139	28	and/or	and/or	CC
cord-003302-vxk7uqlc	139	29	control	control	NN
cord-003302-vxk7uqlc	139	30	of	of	IN
cord-003302-vxk7uqlc	139	31	virus	virus	NN
cord-003302-vxk7uqlc	139	32	replication	replication	NN
cord-003302-vxk7uqlc	139	33	.	.	.
cord-003302-vxk7uqlc	140	1	This	this	DT
cord-003302-vxk7uqlc	140	2	observation	observation	NN
cord-003302-vxk7uqlc	140	3	is	be	VBZ
cord-003302-vxk7uqlc	140	4	critically	critically	RB
cord-003302-vxk7uqlc	140	5	important	important	JJ
cord-003302-vxk7uqlc	140	6	.	.	.
cord-003302-vxk7uqlc	141	1	Although	although	IN
cord-003302-vxk7uqlc	141	2	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	141	3	imprinting	imprinting	NN
cord-003302-vxk7uqlc	141	4	clearly	clearly	RB
cord-003302-vxk7uqlc	141	5	influences	influence	VBZ
cord-003302-vxk7uqlc	141	6	human	human	JJ
cord-003302-vxk7uqlc	141	7	outcomes	outcome	NNS
cord-003302-vxk7uqlc	141	8	in	in	IN
cord-003302-vxk7uqlc	141	9	both	both	DT
cord-003302-vxk7uqlc	141	10	pandemic	pandemic	JJ
cord-003302-vxk7uqlc	141	11	and	and	CC
cord-003302-vxk7uqlc	141	12	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	141	13	influenza	influenza	NN
cord-003302-vxk7uqlc	141	14	[	[	-LRB-
cord-003302-vxk7uqlc	141	15	15	15	CD
cord-003302-vxk7uqlc	141	16	,	,	,
cord-003302-vxk7uqlc	141	17	18	18	CD
cord-003302-vxk7uqlc	141	18	-	-	SYM
cord-003302-vxk7uqlc	141	19	20	20	CD
cord-003302-vxk7uqlc	141	20	,	,	,
cord-003302-vxk7uqlc	141	21	22	22	CD
cord-003302-vxk7uqlc	141	22	,	,	,
cord-003302-vxk7uqlc	141	23	23	23	CD
cord-003302-vxk7uqlc	141	24	]	]	-RRB-
cord-003302-vxk7uqlc	141	25	,	,	,
cord-003302-vxk7uqlc	141	26	differences	difference	NNS
cord-003302-vxk7uqlc	141	27	in	in	IN
cord-003302-vxk7uqlc	141	28	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	141	29	imprinting	imprinting	NN
cord-003302-vxk7uqlc	141	30	might	may	MD
cord-003302-vxk7uqlc	141	31	not	not	RB
cord-003302-vxk7uqlc	141	32	be	be	VB
cord-003302-vxk7uqlc	141	33	the	the	DT
cord-003302-vxk7uqlc	141	34	only	only	JJ
cord-003302-vxk7uqlc	141	35	explanation	explanation	NN
cord-003302-vxk7uqlc	141	36	for	for	IN
cord-003302-vxk7uqlc	141	37	better	well	JJR
cord-003302-vxk7uqlc	141	38	childhood	childhood	NN
cord-003302-vxk7uqlc	141	39	survival	survival	NN
cord-003302-vxk7uqlc	141	40	during	during	IN
cord-003302-vxk7uqlc	141	41	the	the	DT
cord-003302-vxk7uqlc	141	42	1918	1918	CD
cord-003302-vxk7uqlc	141	43	pandemic	pandemic	NN
cord-003302-vxk7uqlc	141	44	.	.	.
cord-003302-vxk7uqlc	142	1	In	in	IN
cord-003302-vxk7uqlc	142	2	attempting	attempt	VBG
cord-003302-vxk7uqlc	142	3	to	to	TO
cord-003302-vxk7uqlc	142	4	understand	understand	VB
cord-003302-vxk7uqlc	142	5	the	the	DT
cord-003302-vxk7uqlc	142	6	'	'	``
cord-003302-vxk7uqlc	142	7	mystery	mystery	NN
cord-003302-vxk7uqlc	142	8	'	'	''
cord-003302-vxk7uqlc	142	9	of	of	IN
cord-003302-vxk7uqlc	142	10	better	well	JJR
cord-003302-vxk7uqlc	142	11	survival	survival	NN
cord-003302-vxk7uqlc	142	12	among	among	IN
cord-003302-vxk7uqlc	142	13	children	child	NNS
cord-003302-vxk7uqlc	142	14	compared	compare	VBN
cord-003302-vxk7uqlc	142	15	with	with	IN
cord-003302-vxk7uqlc	142	16	adults	adult	NNS
cord-003302-vxk7uqlc	142	17	during	during	IN
cord-003302-vxk7uqlc	142	18	the	the	DT
cord-003302-vxk7uqlc	142	19	1918	1918	CD
cord-003302-vxk7uqlc	142	20	pandemic	pandemic	NN
cord-003302-vxk7uqlc	142	21	,	,	,
cord-003302-vxk7uqlc	142	22	investigators	investigator	NNS
cord-003302-vxk7uqlc	142	23	have	have	VBP
cord-003302-vxk7uqlc	142	24	focused	focus	VBN
cord-003302-vxk7uqlc	142	25	exclusively	exclusively	RB
cord-003302-vxk7uqlc	142	26	on	on	IN
cord-003302-vxk7uqlc	142	27	infection	infection	NN
cord-003302-vxk7uqlc	142	28	with	with	IN
cord-003302-vxk7uqlc	142	29	influenza	influenza	NN
cord-003302-vxk7uqlc	142	30	viruses	virus	NNS
cord-003302-vxk7uqlc	142	31	and	and	CC
cord-003302-vxk7uqlc	142	32	ignored	ignore	VBD
cord-003302-vxk7uqlc	142	33	the	the	DT
cord-003302-vxk7uqlc	142	34	better	well	JJR
cord-003302-vxk7uqlc	142	35	survival	survival	NN
cord-003302-vxk7uqlc	142	36	of	of	IN
cord-003302-vxk7uqlc	142	37	children	child	NNS
cord-003302-vxk7uqlc	142	38	with	with	IN
cord-003302-vxk7uqlc	142	39	other	other	JJ
cord-003302-vxk7uqlc	142	40	infectious	infectious	JJ
cord-003302-vxk7uqlc	142	41	diseases	disease	NNS
cord-003302-vxk7uqlc	142	42	and	and	CC
cord-003302-vxk7uqlc	142	43	noninfectious	noninfectious	JJ
cord-003302-vxk7uqlc	142	44	critical	critical	JJ
cord-003302-vxk7uqlc	142	45	illnesses	illness	NNS
cord-003302-vxk7uqlc	142	46	[	[	-LRB-
cord-003302-vxk7uqlc	142	47	6	6	CD
cord-003302-vxk7uqlc	142	48	,	,	,
cord-003302-vxk7uqlc	142	49	10	10	CD
cord-003302-vxk7uqlc	142	50	]	]	-RRB-
cord-003302-vxk7uqlc	142	51	.	.	.
cord-003302-vxk7uqlc	143	1	The	the	DT
cord-003302-vxk7uqlc	143	2	better	well	JJR
cord-003302-vxk7uqlc	143	3	survival	survival	NN
cord-003302-vxk7uqlc	143	4	of	of	IN
cord-003302-vxk7uqlc	143	5	prepubertal	prepubertal	JJ
cord-003302-vxk7uqlc	143	6	mice	mice	NN
cord-003302-vxk7uqlc	143	7	following	follow	VBG
cord-003302-vxk7uqlc	143	8	endotoxin	endotoxin	NN
cord-003302-vxk7uqlc	143	9	treatment	treatment	NN
cord-003302-vxk7uqlc	143	10	shown	show	VBN
cord-003302-vxk7uqlc	143	11	by	by	IN
cord-003302-vxk7uqlc	143	12	Kobzik	Kobzik	NNP
cord-003302-vxk7uqlc	143	13	et	et	NNP
cord-003302-vxk7uqlc	143	14	al	al	NNP
cord-003302-vxk7uqlc	143	15	.	.	NNP
cord-003302-vxk7uqlc	143	16	suggests	suggest	VBZ
cord-003302-vxk7uqlc	143	17	that	that	IN
cord-003302-vxk7uqlc	143	18	this	this	DT
cord-003302-vxk7uqlc	143	19	is	be	VBZ
cord-003302-vxk7uqlc	143	20	a	a	DT
cord-003302-vxk7uqlc	143	21	general	general	JJ
cord-003302-vxk7uqlc	143	22	phenomenon	phenomenon	NN
cord-003302-vxk7uqlc	143	23	.	.	.
cord-003302-vxk7uqlc	144	1	Long	long	RB
cord-003302-vxk7uqlc	144	2	-	-	HYPH
cord-003302-vxk7uqlc	144	3	lasting	last	VBG
cord-003302-vxk7uqlc	144	4	,	,	,
cord-003302-vxk7uqlc	144	5	age	age	NN
cord-003302-vxk7uqlc	144	6	-	-	HYPH
cord-003302-vxk7uqlc	144	7	specific	specific	JJ
cord-003302-vxk7uqlc	144	8	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	144	9	imprinting	imprinting	NN
cord-003302-vxk7uqlc	144	10	seen	see	VBN
cord-003302-vxk7uqlc	144	11	with	with	IN
cord-003302-vxk7uqlc	144	12	influenza	influenza	NN
cord-003302-vxk7uqlc	144	13	is	be	VBZ
cord-003302-vxk7uqlc	144	14	not	not	RB
cord-003302-vxk7uqlc	144	15	known	know	VBN
cord-003302-vxk7uqlc	144	16	to	to	TO
cord-003302-vxk7uqlc	144	17	occur	occur	VB
cord-003302-vxk7uqlc	144	18	with	with	IN
cord-003302-vxk7uqlc	144	19	most	most	JJS
cord-003302-vxk7uqlc	144	20	other	other	JJ
cord-003302-vxk7uqlc	144	21	forms	form	NNS
cord-003302-vxk7uqlc	144	22	of	of	IN
cord-003302-vxk7uqlc	144	23	acute	acute	JJ
cord-003302-vxk7uqlc	144	24	critical	critical	JJ
cord-003302-vxk7uqlc	144	25	illness	illness	NN
cord-003302-vxk7uqlc	144	26	[	[	-LRB-
cord-003302-vxk7uqlc	144	27	6	6	CD
cord-003302-vxk7uqlc	144	28	,	,	,
cord-003302-vxk7uqlc	144	29	10	10	CD
cord-003302-vxk7uqlc	144	30	]	]	-RRB-
cord-003302-vxk7uqlc	144	31	.	.	.
cord-003302-vxk7uqlc	145	1	Instead	instead	RB
cord-003302-vxk7uqlc	145	2	,	,	,
cord-003302-vxk7uqlc	145	3	changes	change	NNS
cord-003302-vxk7uqlc	145	4	in	in	IN
cord-003302-vxk7uqlc	145	5	the	the	DT
cord-003302-vxk7uqlc	145	6	host	host	NN
cord-003302-vxk7uqlc	145	7	response	response	NN
cord-003302-vxk7uqlc	145	8	to	to	IN
cord-003302-vxk7uqlc	145	9	critical	critical	JJ
cord-003302-vxk7uqlc	145	10	illness	illness	NN
cord-003302-vxk7uqlc	145	11	associated	associate	VBN
cord-003302-vxk7uqlc	145	12	with	with	IN
cord-003302-vxk7uqlc	145	13	increased	increase	VBN
cord-003302-vxk7uqlc	145	14	mortality	mortality	NN
cord-003302-vxk7uqlc	145	15	appear	appear	VBP
cord-003302-vxk7uqlc	145	16	to	to	TO
cord-003302-vxk7uqlc	145	17	begin	begin	VB
cord-003302-vxk7uqlc	145	18	with	with	IN
cord-003302-vxk7uqlc	145	19	the	the	DT
cord-003302-vxk7uqlc	145	20	onset	onset	NN
cord-003302-vxk7uqlc	145	21	of	of	IN
cord-003302-vxk7uqlc	145	22	puberty	puberty	NN
cord-003302-vxk7uqlc	145	23	.	.	.
cord-003302-vxk7uqlc	146	1	It	-PRON-	PRP
cord-003302-vxk7uqlc	146	2	follows	follow	VBZ
cord-003302-vxk7uqlc	146	3	that	that	IN
cord-003302-vxk7uqlc	146	4	factors	factor	NNS
cord-003302-vxk7uqlc	146	5	associated	associate	VBN
cord-003302-vxk7uqlc	146	6	with	with	IN
cord-003302-vxk7uqlc	146	7	prepuberty	prepuberty	NNP
cord-003302-vxk7uqlc	146	8	might	may	MD
cord-003302-vxk7uqlc	146	9	somehow	somehow	RB
cord-003302-vxk7uqlc	146	10	contribute	contribute	VB
cord-003302-vxk7uqlc	146	11	to	to	IN
cord-003302-vxk7uqlc	146	12	the	the	DT
cord-003302-vxk7uqlc	146	13	better	well	JJR
cord-003302-vxk7uqlc	146	14	survival	survival	NN
cord-003302-vxk7uqlc	146	15	of	of	IN
cord-003302-vxk7uqlc	146	16	children	child	NNS
cord-003302-vxk7uqlc	146	17	compared	compare	VBN
cord-003302-vxk7uqlc	146	18	with	with	IN
cord-003302-vxk7uqlc	146	19	adults	adult	NNS
cord-003302-vxk7uqlc	146	20	.	.	.
cord-003302-vxk7uqlc	147	1	Infection	infection	NN
cord-003302-vxk7uqlc	147	2	with	with	IN
cord-003302-vxk7uqlc	147	3	influenza	influenza	NN
cord-003302-vxk7uqlc	147	4	viruses	virus	NNS
cord-003302-vxk7uqlc	147	5	initially	initially	RB
cord-003302-vxk7uqlc	147	6	targets	target	VBZ
cord-003302-vxk7uqlc	147	7	respiratory	respiratory	JJ
cord-003302-vxk7uqlc	147	8	epithelial	epithelial	JJ
cord-003302-vxk7uqlc	147	9	cells	cell	NNS
cord-003302-vxk7uqlc	147	10	[	[	-LRB-
cord-003302-vxk7uqlc	147	11	31	31	CD
cord-003302-vxk7uqlc	147	12	,	,	,
cord-003302-vxk7uqlc	147	13	32	32	CD
cord-003302-vxk7uqlc	147	14	]	]	-RRB-
cord-003302-vxk7uqlc	147	15	.	.	.
cord-003302-vxk7uqlc	148	1	In	in	IN
cord-003302-vxk7uqlc	148	2	response	response	NN
cord-003302-vxk7uqlc	148	3	,	,	,
cord-003302-vxk7uqlc	148	4	myeloid	myeloid	NN
cord-003302-vxk7uqlc	148	5	and	and	CC
cord-003302-vxk7uqlc	148	6	lymphoid	lymphoid	JJ
cord-003302-vxk7uqlc	148	7	cells	cell	NNS
cord-003302-vxk7uqlc	148	8	mount	mount	VBP
cord-003302-vxk7uqlc	148	9	a	a	DT
cord-003302-vxk7uqlc	148	10	brisk	brisk	JJ
cord-003302-vxk7uqlc	148	11	pro	pro	JJ
cord-003302-vxk7uqlc	148	12	-	-	JJ
cord-003302-vxk7uqlc	148	13	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	148	14	response	response	NN
cord-003302-vxk7uqlc	148	15	,	,	,
cord-003302-vxk7uqlc	148	16	often	often	RB
cord-003302-vxk7uqlc	148	17	called	call	VBD
cord-003302-vxk7uqlc	148	18	a	a	DT
cord-003302-vxk7uqlc	148	19	'	'	``
cord-003302-vxk7uqlc	148	20	cytokine	cytokine	NN
cord-003302-vxk7uqlc	148	21	storm	storm	NN
cord-003302-vxk7uqlc	148	22	'	'	''
cord-003302-vxk7uqlc	148	23	.	.	.
cord-003302-vxk7uqlc	149	1	Patients	patient	NNS
cord-003302-vxk7uqlc	149	2	who	who	WP
cord-003302-vxk7uqlc	149	3	develop	develop	VBP
cord-003302-vxk7uqlc	149	4	severe	severe	JJ
cord-003302-vxk7uqlc	149	5	illness	illness	NN
cord-003302-vxk7uqlc	149	6	are	be	VBP
cord-003302-vxk7uqlc	149	7	unable	unable	JJ
cord-003302-vxk7uqlc	149	8	to	to	TO
cord-003302-vxk7uqlc	149	9	control	control	VB
cord-003302-vxk7uqlc	149	10	what	what	WP
cord-003302-vxk7uqlc	149	11	becomes	become	VBZ
cord-003302-vxk7uqlc	149	12	a	a	DT
cord-003302-vxk7uqlc	149	13	systemically	systemically	RB
cord-003302-vxk7uqlc	149	14	dysregulated	dysregulate	VBN
cord-003302-vxk7uqlc	149	15	immune	immune	JJ
cord-003302-vxk7uqlc	149	16	response	response	NN
cord-003302-vxk7uqlc	149	17	.	.	.
cord-003302-vxk7uqlc	150	1	After	after	IN
cord-003302-vxk7uqlc	150	2	several	several	JJ
cord-003302-vxk7uqlc	150	3	days	day	NNS
cord-003302-vxk7uqlc	150	4	(	(	-LRB-
cord-003302-vxk7uqlc	150	5	usually	usually	RB
cord-003302-vxk7uqlc	150	6	a	a	DT
cord-003302-vxk7uqlc	150	7	week	week	NN
cord-003302-vxk7uqlc	150	8	or	or	CC
cord-003302-vxk7uqlc	150	9	more	more	JJR
cord-003302-vxk7uqlc	150	10	)	)	-RRB-
cord-003302-vxk7uqlc	150	11	,	,	,
cord-003302-vxk7uqlc	150	12	they	-PRON-	PRP
cord-003302-vxk7uqlc	150	13	develop	develop	VBP
cord-003302-vxk7uqlc	150	14	evidence	evidence	NN
cord-003302-vxk7uqlc	150	15	of	of	IN
cord-003302-vxk7uqlc	150	16	immunosuppression	immunosuppression	NN
cord-003302-vxk7uqlc	150	17	[	[	-LRB-
cord-003302-vxk7uqlc	150	18	6	6	CD
cord-003302-vxk7uqlc	150	19	,	,	,
cord-003302-vxk7uqlc	150	20	32	32	CD
cord-003302-vxk7uqlc	150	21	]	]	-RRB-
cord-003302-vxk7uqlc	150	22	.	.	.
cord-003302-vxk7uqlc	151	1	Death	death	NN
cord-003302-vxk7uqlc	151	2	occurs	occur	VBZ
cord-003302-vxk7uqlc	151	3	in	in	IN
cord-003302-vxk7uqlc	151	4	those	those	DT
cord-003302-vxk7uqlc	151	5	who	who	WP
cord-003302-vxk7uqlc	151	6	are	be	VBP
cord-003302-vxk7uqlc	151	7	unable	unable	JJ
cord-003302-vxk7uqlc	151	8	to	to	TO
cord-003302-vxk7uqlc	151	9	resolve	resolve	VB
cord-003302-vxk7uqlc	151	10	their	-PRON-	PRP$
cord-003302-vxk7uqlc	151	11	illness	illness	NN
cord-003302-vxk7uqlc	151	12	and	and	CC
cord-003302-vxk7uqlc	151	13	restore	restore	VB
cord-003302-vxk7uqlc	151	14	homeostasis	homeostasis	NN
cord-003302-vxk7uqlc	151	15	.	.	.
cord-003302-vxk7uqlc	152	1	The	the	DT
cord-003302-vxk7uqlc	152	2	pathogenesis	pathogenesis	NN
cord-003302-vxk7uqlc	152	3	of	of	IN
cord-003302-vxk7uqlc	152	4	acute	acute	JJ
cord-003302-vxk7uqlc	152	5	lung	lung	NN
cord-003302-vxk7uqlc	152	6	injury	injury	NN
cord-003302-vxk7uqlc	152	7	,	,	,
cord-003302-vxk7uqlc	152	8	including	include	VBG
cord-003302-vxk7uqlc	152	9	severe	severe	JJ
cord-003302-vxk7uqlc	152	10	influenza	influenza	NN
cord-003302-vxk7uqlc	152	11	,	,	,
cord-003302-vxk7uqlc	152	12	involves	involve	VBZ
cord-003302-vxk7uqlc	152	13	(	(	-LRB-
cord-003302-vxk7uqlc	152	14	among	among	IN
cord-003302-vxk7uqlc	152	15	other	other	JJ
cord-003302-vxk7uqlc	152	16	things	thing	NNS
cord-003302-vxk7uqlc	152	17	)	)	-RRB-
cord-003302-vxk7uqlc	153	1	mitochondrial	mitochondrial	JJ
cord-003302-vxk7uqlc	153	2	dysfunction	dysfunction	NN
cord-003302-vxk7uqlc	153	3	[	[	-LRB-
cord-003302-vxk7uqlc	153	4	33	33	CD
cord-003302-vxk7uqlc	153	5	]	]	-RRB-
cord-003302-vxk7uqlc	153	6	,	,	,
cord-003302-vxk7uqlc	153	7	oxidative	oxidative	JJ
cord-003302-vxk7uqlc	153	8	stress	stress	NN
cord-003302-vxk7uqlc	153	9	[	[	-LRB-
cord-003302-vxk7uqlc	153	10	34	34	CD
cord-003302-vxk7uqlc	153	11	,	,	,
cord-003302-vxk7uqlc	153	12	35	35	CD
cord-003302-vxk7uqlc	153	13	]	]	-RRB-
cord-003302-vxk7uqlc	153	14	,	,	,
cord-003302-vxk7uqlc	153	15	endothelial	endothelial	JJ
cord-003302-vxk7uqlc	153	16	dysfunction	dysfunction	NN
cord-003302-vxk7uqlc	153	17	[	[	-LRB-
cord-003302-vxk7uqlc	153	18	36	36	CD
cord-003302-vxk7uqlc	153	19	,	,	,
cord-003302-vxk7uqlc	153	20	37	37	CD
cord-003302-vxk7uqlc	153	21	]	]	-RRB-
cord-003302-vxk7uqlc	153	22	and	and	CC
cord-003302-vxk7uqlc	153	23	molecular	molecular	JJ
cord-003302-vxk7uqlc	153	24	mechanisms	mechanism	NNS
cord-003302-vxk7uqlc	153	25	(	(	-LRB-
cord-003302-vxk7uqlc	153	26	e.g.	e.g.	IN
cord-003302-vxk7uqlc	153	27	specific	specific	JJ
cord-003302-vxk7uqlc	153	28	lipid	lipid	NN
cord-003302-vxk7uqlc	153	29	mediators	mediator	NNS
cord-003302-vxk7uqlc	153	30	)	)	-RRB-
cord-003302-vxk7uqlc	153	31	that	that	WDT
cord-003302-vxk7uqlc	153	32	initiate	initiate	VBP
cord-003302-vxk7uqlc	153	33	the	the	DT
cord-003302-vxk7uqlc	153	34	resolution	resolution	NN
cord-003302-vxk7uqlc	153	35	of	of	IN
cord-003302-vxk7uqlc	153	36	pulmonary	pulmonary	JJ
cord-003302-vxk7uqlc	153	37	and	and	CC
cord-003302-vxk7uqlc	153	38	systemic	systemic	JJ
cord-003302-vxk7uqlc	153	39	injury	injury	NN
cord-003302-vxk7uqlc	153	40	and	and	CC
cord-003302-vxk7uqlc	153	41	the	the	DT
cord-003302-vxk7uqlc	153	42	restoration	restoration	NN
cord-003302-vxk7uqlc	153	43	of	of	IN
cord-003302-vxk7uqlc	153	44	homeostasis	homeostasis	NN
cord-003302-vxk7uqlc	153	45	[	[	-LRB-
cord-003302-vxk7uqlc	153	46	38	38	CD
cord-003302-vxk7uqlc	153	47	,	,	,
cord-003302-vxk7uqlc	153	48	39	39	CD
cord-003302-vxk7uqlc	153	49	]	]	-RRB-
cord-003302-vxk7uqlc	153	50	.	.	.
cord-003302-vxk7uqlc	154	1	The	the	DT
cord-003302-vxk7uqlc	154	2	evolutionarily	evolutionarily	RB
cord-003302-vxk7uqlc	154	3	conserved	conserved	JJ
cord-003302-vxk7uqlc	154	4	process	process	NN
cord-003302-vxk7uqlc	154	5	of	of	IN
cord-003302-vxk7uqlc	154	6	autophagy	autophagy	NN
cord-003302-vxk7uqlc	154	7	is	be	VBZ
cord-003302-vxk7uqlc	154	8	central	central	JJ
cord-003302-vxk7uqlc	154	9	to	to	IN
cord-003302-vxk7uqlc	154	10	the	the	DT
cord-003302-vxk7uqlc	154	11	host	host	NN
cord-003302-vxk7uqlc	154	12	response	response	NN
cord-003302-vxk7uqlc	154	13	[	[	-LRB-
cord-003302-vxk7uqlc	154	14	40	40	CD
cord-003302-vxk7uqlc	154	15	]	]	-RRB-
cord-003302-vxk7uqlc	154	16	;	;	:
cord-003302-vxk7uqlc	154	17	it	-PRON-	PRP
cord-003302-vxk7uqlc	154	18	contributes	contribute	VBZ
cord-003302-vxk7uqlc	154	19	to	to	IN
cord-003302-vxk7uqlc	154	20	both	both	DT
cord-003302-vxk7uqlc	154	21	influenza	influenza	NN
cord-003302-vxk7uqlc	154	22	virus	virus	NN
cord-003302-vxk7uqlc	154	23	replication	replication	NN
cord-003302-vxk7uqlc	154	24	[	[	-LRB-
cord-003302-vxk7uqlc	154	25	41	41	CD
cord-003302-vxk7uqlc	154	26	]	]	-RRB-
cord-003302-vxk7uqlc	154	27	and	and	CC
cord-003302-vxk7uqlc	154	28	the	the	DT
cord-003302-vxk7uqlc	154	29	evolution	evolution	NN
cord-003302-vxk7uqlc	154	30	of	of	IN
cord-003302-vxk7uqlc	154	31	influenza	influenza	NN
cord-003302-vxk7uqlc	154	32	-	-	HYPH
cord-003302-vxk7uqlc	154	33	related	relate	VBN
cord-003302-vxk7uqlc	154	34	lung	lung	NN
cord-003302-vxk7uqlc	154	35	injury	injury	NN
cord-003302-vxk7uqlc	154	36	[	[	-LRB-
cord-003302-vxk7uqlc	154	37	42	42	CD
cord-003302-vxk7uqlc	154	38	,	,	,
cord-003302-vxk7uqlc	154	39	43	43	CD
cord-003302-vxk7uqlc	154	40	]	]	-RRB-
cord-003302-vxk7uqlc	154	41	.	.	.
cord-003302-vxk7uqlc	155	1	The	the	DT
cord-003302-vxk7uqlc	155	2	host	host	NN
cord-003302-vxk7uqlc	155	3	response	response	NN
cord-003302-vxk7uqlc	155	4	to	to	IN
cord-003302-vxk7uqlc	155	5	infection	infection	NN
cord-003302-vxk7uqlc	155	6	may	may	MD
cord-003302-vxk7uqlc	155	7	involve	involve	VB
cord-003302-vxk7uqlc	155	8	mechanisms	mechanism	NNS
cord-003302-vxk7uqlc	155	9	that	that	WDT
cord-003302-vxk7uqlc	155	10	enhance	enhance	VBP
cord-003302-vxk7uqlc	155	11	resistance	resistance	NN
cord-003302-vxk7uqlc	155	12	(	(	-LRB-
cord-003302-vxk7uqlc	155	13	which	which	WDT
cord-003302-vxk7uqlc	155	14	reduces	reduce	VBZ
cord-003302-vxk7uqlc	155	15	pathogen	pathogen	NN
cord-003302-vxk7uqlc	155	16	burden	burden	NN
cord-003302-vxk7uqlc	155	17	)	)	-RRB-
cord-003302-vxk7uqlc	155	18	or	or	CC
cord-003302-vxk7uqlc	155	19	tolerance	tolerance	NN
cord-003302-vxk7uqlc	155	20	(	(	-LRB-
cord-003302-vxk7uqlc	155	21	which	which	WDT
cord-003302-vxk7uqlc	155	22	reduces	reduce	VBZ
cord-003302-vxk7uqlc	155	23	the	the	DT
cord-003302-vxk7uqlc	155	24	impact	impact	NN
cord-003302-vxk7uqlc	155	25	of	of	IN
cord-003302-vxk7uqlc	155	26	infection	infection	NN
cord-003302-vxk7uqlc	155	27	)	)	-RRB-
cord-003302-vxk7uqlc	155	28	[	[	-LRB-
cord-003302-vxk7uqlc	155	29	44	44	CD
cord-003302-vxk7uqlc	155	30	,	,	,
cord-003302-vxk7uqlc	155	31	45	45	CD
cord-003302-vxk7uqlc	155	32	]	]	-RRB-
cord-003302-vxk7uqlc	155	33	.	.	.
cord-003302-vxk7uqlc	156	1	Both	both	DT
cord-003302-vxk7uqlc	156	2	resistance	resistance	NN
cord-003302-vxk7uqlc	156	3	and	and	CC
cord-003302-vxk7uqlc	156	4	tolerance	tolerance	NN
cord-003302-vxk7uqlc	156	5	are	be	VBP
cord-003302-vxk7uqlc	156	6	driven	drive	VBN
cord-003302-vxk7uqlc	156	7	by	by	IN
cord-003302-vxk7uqlc	156	8	a	a	DT
cord-003302-vxk7uqlc	156	9	multiplicity	multiplicity	NN
cord-003302-vxk7uqlc	156	10	of	of	IN
cord-003302-vxk7uqlc	156	11	metabolic	metabolic	JJ
cord-003302-vxk7uqlc	156	12	changes	change	NNS
cord-003302-vxk7uqlc	156	13	in	in	IN
cord-003302-vxk7uqlc	156	14	immune	immune	JJ
cord-003302-vxk7uqlc	156	15	and	and	CC
cord-003302-vxk7uqlc	156	16	other	other	JJ
cord-003302-vxk7uqlc	156	17	host	host	NN
cord-003302-vxk7uqlc	156	18	cells	cell	NNS
cord-003302-vxk7uqlc	156	19	[	[	-LRB-
cord-003302-vxk7uqlc	156	20	46	46	CD
cord-003302-vxk7uqlc	156	21	]	]	-RRB-
cord-003302-vxk7uqlc	156	22	[	[	-LRB-
cord-003302-vxk7uqlc	156	23	47	47	CD
cord-003302-vxk7uqlc	156	24	]	]	-RRB-
cord-003302-vxk7uqlc	156	25	[	[	-LRB-
cord-003302-vxk7uqlc	156	26	48	48	CD
cord-003302-vxk7uqlc	156	27	]	]	-RRB-
cord-003302-vxk7uqlc	156	28	[	[	-LRB-
cord-003302-vxk7uqlc	156	29	49	49	CD
cord-003302-vxk7uqlc	156	30	]	]	-RRB-
cord-003302-vxk7uqlc	156	31	,	,	,
cord-003302-vxk7uqlc	156	32	some	some	DT
cord-003302-vxk7uqlc	156	33	of	of	IN
cord-003302-vxk7uqlc	156	34	which	which	WDT
cord-003302-vxk7uqlc	156	35	include	include	VBP
cord-003302-vxk7uqlc	156	36	estrogen	estrogen	NN
cord-003302-vxk7uqlc	156	37	signaling	signal	VBG
cord-003302-vxk7uqlc	156	38	[	[	-LRB-
cord-003302-vxk7uqlc	156	39	50	50	CD
cord-003302-vxk7uqlc	156	40	]	]	-RRB-
cord-003302-vxk7uqlc	156	41	.	.	.
cord-003302-vxk7uqlc	157	1	Some	some	DT
cord-003302-vxk7uqlc	157	2	of	of	IN
cord-003302-vxk7uqlc	157	3	these	these	DT
cord-003302-vxk7uqlc	157	4	immunometabolic	immunometabolic	JJ
cord-003302-vxk7uqlc	157	5	changes	change	NNS
cord-003302-vxk7uqlc	157	6	have	have	VBP
cord-003302-vxk7uqlc	157	7	been	be	VBN
cord-003302-vxk7uqlc	157	8	documented	document	VBN
cord-003302-vxk7uqlc	157	9	in	in	IN
cord-003302-vxk7uqlc	157	10	mice	mouse	NNS
cord-003302-vxk7uqlc	157	11	with	with	IN
cord-003302-vxk7uqlc	157	12	experimental	experimental	JJ
cord-003302-vxk7uqlc	157	13	influenza	influenza	NN
cord-003302-vxk7uqlc	157	14	virus	virus	NN
cord-003302-vxk7uqlc	157	15	infection	infection	NN
cord-003302-vxk7uqlc	157	16	[	[	-LRB-
cord-003302-vxk7uqlc	157	17	51	51	CD
cord-003302-vxk7uqlc	157	18	]	]	-RRB-
cord-003302-vxk7uqlc	157	19	.	.	.
cord-003302-vxk7uqlc	158	1	The	the	DT
cord-003302-vxk7uqlc	158	2	molecular	molecular	JJ
cord-003302-vxk7uqlc	158	3	mechanisms	mechanism	NNS
cord-003302-vxk7uqlc	158	4	that	that	WDT
cord-003302-vxk7uqlc	158	5	account	account	VBP
cord-003302-vxk7uqlc	158	6	for	for	IN
cord-003302-vxk7uqlc	158	7	the	the	DT
cord-003302-vxk7uqlc	158	8	difference	difference	NN
cord-003302-vxk7uqlc	158	9	in	in	IN
cord-003302-vxk7uqlc	158	10	the	the	DT
cord-003302-vxk7uqlc	158	11	mortality	mortality	NN
cord-003302-vxk7uqlc	158	12	rates	rate	NNS
cord-003302-vxk7uqlc	158	13	of	of	IN
cord-003302-vxk7uqlc	158	14	children	child	NNS
cord-003302-vxk7uqlc	158	15	and	and	CC
cord-003302-vxk7uqlc	158	16	adults	adult	NNS
cord-003302-vxk7uqlc	158	17	with	with	IN
cord-003302-vxk7uqlc	158	18	different	different	JJ
cord-003302-vxk7uqlc	158	19	forms	form	NNS
cord-003302-vxk7uqlc	158	20	of	of	IN
cord-003302-vxk7uqlc	158	21	acute	acute	JJ
cord-003302-vxk7uqlc	158	22	critical	critical	JJ
cord-003302-vxk7uqlc	158	23	illness	illness	NN
cord-003302-vxk7uqlc	158	24	(	(	-LRB-
cord-003302-vxk7uqlc	158	25	seen	see	VBN
cord-003302-vxk7uqlc	158	26	in	in	IN
cord-003302-vxk7uqlc	158	27	humans	human	NNS
cord-003302-vxk7uqlc	158	28	and	and	CC
cord-003302-vxk7uqlc	158	29	now	now	RB
cord-003302-vxk7uqlc	158	30	replicated	replicate	VBN
cord-003302-vxk7uqlc	158	31	in	in	IN
cord-003302-vxk7uqlc	158	32	mice	mouse	NNS
cord-003302-vxk7uqlc	158	33	)	)	-RRB-
cord-003302-vxk7uqlc	158	34	are	be	VBP
cord-003302-vxk7uqlc	158	35	largely	largely	RB
cord-003302-vxk7uqlc	158	36	unknown	unknown	JJ
cord-003302-vxk7uqlc	158	37	.	.	.
cord-003302-vxk7uqlc	159	1	Working	work	VBG
cord-003302-vxk7uqlc	159	2	together	together	RB
cord-003302-vxk7uqlc	159	3	,	,	,
cord-003302-vxk7uqlc	159	4	the	the	DT
cord-003302-vxk7uqlc	159	5	endocrine	endocrine	NN
cord-003302-vxk7uqlc	159	6	,	,	,
cord-003302-vxk7uqlc	159	7	nervous	nervous	JJ
cord-003302-vxk7uqlc	159	8	and	and	CC
cord-003302-vxk7uqlc	159	9	immune	immune	JJ
cord-003302-vxk7uqlc	159	10	systems	system	NNS
cord-003302-vxk7uqlc	159	11	integrate	integrate	VBP
cord-003302-vxk7uqlc	159	12	and	and	CC
cord-003302-vxk7uqlc	159	13	regulate	regulate	VB
cord-003302-vxk7uqlc	159	14	the	the	DT
cord-003302-vxk7uqlc	159	15	availability	availability	NN
cord-003302-vxk7uqlc	159	16	of	of	IN
cord-003302-vxk7uqlc	159	17	energy	energy	NN
cord-003302-vxk7uqlc	159	18	.	.	.
cord-003302-vxk7uqlc	160	1	Evolutionary	evolutionary	JJ
cord-003302-vxk7uqlc	160	2	biologists	biologist	NNS
cord-003302-vxk7uqlc	160	3	have	have	VBP
cord-003302-vxk7uqlc	160	4	developed	develop	VBN
cord-003302-vxk7uqlc	160	5	the	the	DT
cord-003302-vxk7uqlc	160	6	theory	theory	NN
cord-003302-vxk7uqlc	160	7	of	of	IN
cord-003302-vxk7uqlc	160	8	life	life	NN
cord-003302-vxk7uqlc	160	9	history	history	NN
cord-003302-vxk7uqlc	160	10	,	,	,
cord-003302-vxk7uqlc	160	11	which	which	WDT
cord-003302-vxk7uqlc	160	12	emphasizes	emphasize	VBZ
cord-003302-vxk7uqlc	160	13	trade	trade	NN
cord-003302-vxk7uqlc	160	14	-	-	HYPH
cord-003302-vxk7uqlc	160	15	offs	off	NNS
cord-003302-vxk7uqlc	160	16	in	in	IN
cord-003302-vxk7uqlc	160	17	how	how	WRB
cord-003302-vxk7uqlc	160	18	energy	energy	NN
cord-003302-vxk7uqlc	160	19	is	be	VBZ
cord-003302-vxk7uqlc	160	20	allocated	allocate	VBN
cord-003302-vxk7uqlc	160	21	to	to	IN
cord-003302-vxk7uqlc	160	22	storage	storage	NN
cord-003302-vxk7uqlc	160	23	,	,	,
cord-003302-vxk7uqlc	160	24	activity	activity	NN
cord-003302-vxk7uqlc	160	25	,	,	,
cord-003302-vxk7uqlc	160	26	maintenance	maintenance	NN
cord-003302-vxk7uqlc	160	27	,	,	,
cord-003302-vxk7uqlc	160	28	and	and	CC
cord-003302-vxk7uqlc	160	29	the	the	DT
cord-003302-vxk7uqlc	160	30	anabolic	anabolic	JJ
cord-003302-vxk7uqlc	160	31	activities	activity	NNS
cord-003302-vxk7uqlc	160	32	of	of	IN
cord-003302-vxk7uqlc	160	33	growth	growth	NN
cord-003302-vxk7uqlc	160	34	and	and	CC
cord-003302-vxk7uqlc	160	35	reproduction	reproduction	NN
cord-003302-vxk7uqlc	160	36	[	[	-LRB-
cord-003302-vxk7uqlc	160	37	52	52	CD
cord-003302-vxk7uqlc	160	38	]	]	-RRB-
cord-003302-vxk7uqlc	160	39	.	.	.
cord-003302-vxk7uqlc	161	1	According	accord	VBG
cord-003302-vxk7uqlc	161	2	to	to	IN
cord-003302-vxk7uqlc	161	3	life	life	NN
cord-003302-vxk7uqlc	161	4	history	history	NN
cord-003302-vxk7uqlc	161	5	theory	theory	NN
cord-003302-vxk7uqlc	161	6	,	,	,
cord-003302-vxk7uqlc	161	7	the	the	DT
cord-003302-vxk7uqlc	161	8	transition	transition	NN
cord-003302-vxk7uqlc	161	9	to	to	IN
cord-003302-vxk7uqlc	161	10	puberty	puberty	NN
cord-003302-vxk7uqlc	161	11	is	be	VBZ
cord-003302-vxk7uqlc	161	12	accompanied	accompany	VBN
cord-003302-vxk7uqlc	161	13	by	by	IN
cord-003302-vxk7uqlc	161	14	an	an	DT
cord-003302-vxk7uqlc	161	15	overall	overall	JJ
cord-003302-vxk7uqlc	161	16	switch	switch	NN
cord-003302-vxk7uqlc	161	17	in	in	IN
cord-003302-vxk7uqlc	161	18	the	the	DT
cord-003302-vxk7uqlc	161	19	allocation	allocation	NN
cord-003302-vxk7uqlc	161	20	of	of	IN
cord-003302-vxk7uqlc	161	21	energy	energy	NN
cord-003302-vxk7uqlc	161	22	from	from	IN
cord-003302-vxk7uqlc	161	23	growth	growth	NN
cord-003302-vxk7uqlc	161	24	to	to	IN
cord-003302-vxk7uqlc	161	25	reproduction	reproduction	NN
cord-003302-vxk7uqlc	161	26	.	.	.
cord-003302-vxk7uqlc	162	1	Nonetheless	nonetheless	RB
cord-003302-vxk7uqlc	162	2	,	,	,
cord-003302-vxk7uqlc	162	3	although	although	IN
cord-003302-vxk7uqlc	162	4	this	this	DT
cord-003302-vxk7uqlc	162	5	theory	theory	NN
cord-003302-vxk7uqlc	162	6	has	have	VBZ
cord-003302-vxk7uqlc	162	7	given	give	VBN
cord-003302-vxk7uqlc	162	8	us	-PRON-	PRP
cord-003302-vxk7uqlc	162	9	a	a	DT
cord-003302-vxk7uqlc	162	10	better	well	JJR
cord-003302-vxk7uqlc	162	11	understanding	understanding	NN
cord-003302-vxk7uqlc	162	12	of	of	IN
cord-003302-vxk7uqlc	162	13	changes	change	NNS
cord-003302-vxk7uqlc	162	14	in	in	IN
cord-003302-vxk7uqlc	162	15	energy	energy	NN
cord-003302-vxk7uqlc	162	16	metabolism	metabolism	NN
cord-003302-vxk7uqlc	162	17	that	that	WDT
cord-003302-vxk7uqlc	162	18	occur	occur	VBP
cord-003302-vxk7uqlc	162	19	over	over	IN
cord-003302-vxk7uqlc	162	20	extended	extend	VBN
cord-003302-vxk7uqlc	162	21	periods	period	NNS
cord-003302-vxk7uqlc	162	22	of	of	IN
cord-003302-vxk7uqlc	162	23	time	time	NN
cord-003302-vxk7uqlc	162	24	,	,	,
cord-003302-vxk7uqlc	162	25	it	-PRON-	PRP
cord-003302-vxk7uqlc	162	26	has	have	VBZ
cord-003302-vxk7uqlc	162	27	yet	yet	RB
cord-003302-vxk7uqlc	162	28	to	to	TO
cord-003302-vxk7uqlc	162	29	explain	explain	VB
cord-003302-vxk7uqlc	162	30	the	the	DT
cord-003302-vxk7uqlc	162	31	sudden	sudden	JJ
cord-003302-vxk7uqlc	162	32	and	and	CC
cord-003302-vxk7uqlc	162	33	intense	intense	JJ
cord-003302-vxk7uqlc	162	34	increase	increase	NN
cord-003302-vxk7uqlc	162	35	in	in	IN
cord-003302-vxk7uqlc	162	36	energy	energy	NN
cord-003302-vxk7uqlc	162	37	expenditure	expenditure	NN
cord-003302-vxk7uqlc	162	38	that	that	WDT
cord-003302-vxk7uqlc	162	39	accompanies	accompany	VBZ
cord-003302-vxk7uqlc	162	40	the	the	DT
cord-003302-vxk7uqlc	162	41	host	host	NN
cord-003302-vxk7uqlc	162	42	response	response	NN
cord-003302-vxk7uqlc	162	43	to	to	IN
cord-003302-vxk7uqlc	162	44	acute	acute	JJ
cord-003302-vxk7uqlc	162	45	critical	critical	JJ
cord-003302-vxk7uqlc	162	46	illness	illness	NN
cord-003302-vxk7uqlc	162	47	or	or	CC
cord-003302-vxk7uqlc	162	48	whether	whether	IN
cord-003302-vxk7uqlc	162	49	tradeoffs	tradeoff	NNS
cord-003302-vxk7uqlc	162	50	in	in	IN
cord-003302-vxk7uqlc	162	51	energy	energy	NN
cord-003302-vxk7uqlc	162	52	allocation	allocation	NN
cord-003302-vxk7uqlc	162	53	in	in	IN
cord-003302-vxk7uqlc	162	54	critical	critical	JJ
cord-003302-vxk7uqlc	162	55	illness	illness	NN
cord-003302-vxk7uqlc	162	56	are	be	VBP
cord-003302-vxk7uqlc	162	57	different	different	JJ
cord-003302-vxk7uqlc	162	58	before	before	IN
cord-003302-vxk7uqlc	162	59	and	and	CC
cord-003302-vxk7uqlc	162	60	after	after	IN
cord-003302-vxk7uqlc	162	61	puberty	puberty	NN
cord-003302-vxk7uqlc	162	62	.	.	.
cord-003302-vxk7uqlc	163	1	In	in	IN
cord-003302-vxk7uqlc	163	2	outbreaks	outbreak	NNS
cord-003302-vxk7uqlc	163	3	of	of	IN
cord-003302-vxk7uqlc	163	4	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	163	5	and	and	CC
cord-003302-vxk7uqlc	163	6	pandemic	pandemic	NN
cord-003302-vxk7uqlc	163	7	influenza	influenza	NN
cord-003302-vxk7uqlc	163	8	,	,	,
cord-003302-vxk7uqlc	163	9	only	only	RB
cord-003302-vxk7uqlc	163	10	a	a	DT
cord-003302-vxk7uqlc	163	11	small	small	JJ
cord-003302-vxk7uqlc	163	12	number	number	NN
cord-003302-vxk7uqlc	163	13	of	of	IN
cord-003302-vxk7uqlc	163	14	individuals	individual	NNS
cord-003302-vxk7uqlc	163	15	who	who	WP
cord-003302-vxk7uqlc	163	16	are	be	VBP
cord-003302-vxk7uqlc	163	17	infected	infect	VBN
cord-003302-vxk7uqlc	163	18	develop	develop	VBP
cord-003302-vxk7uqlc	163	19	severe	severe	JJ
cord-003302-vxk7uqlc	163	20	or	or	CC
cord-003302-vxk7uqlc	163	21	fatal	fatal	JJ
cord-003302-vxk7uqlc	163	22	illness	illness	NN
cord-003302-vxk7uqlc	163	23	.	.	.
cord-003302-vxk7uqlc	164	1	This	this	DT
cord-003302-vxk7uqlc	164	2	was	be	VBD
cord-003302-vxk7uqlc	164	3	true	true	JJ
cord-003302-vxk7uqlc	164	4	during	during	IN
cord-003302-vxk7uqlc	164	5	the	the	DT
cord-003302-vxk7uqlc	164	6	1918	1918	CD
cord-003302-vxk7uqlc	164	7	pandemic	pandemic	NN
cord-003302-vxk7uqlc	164	8	;	;	:
cord-003302-vxk7uqlc	164	9	although	although	IN
cord-003302-vxk7uqlc	164	10	approximately	approximately	RB
cord-003302-vxk7uqlc	164	11	one	one	CD
cord-003302-vxk7uqlc	164	12	-	-	HYPH
cord-003302-vxk7uqlc	164	13	third	third	NN
cord-003302-vxk7uqlc	164	14	of	of	IN
cord-003302-vxk7uqlc	164	15	the	the	DT
cord-003302-vxk7uqlc	164	16	human	human	JJ
cord-003302-vxk7uqlc	164	17	population	population	NN
cord-003302-vxk7uqlc	164	18	was	be	VBD
cord-003302-vxk7uqlc	164	19	infected	infect	VBN
cord-003302-vxk7uqlc	164	20	,	,	,
cord-003302-vxk7uqlc	164	21	only	only	RB
cord-003302-vxk7uqlc	164	22	a	a	DT
cord-003302-vxk7uqlc	164	23	small	small	JJ
cord-003302-vxk7uqlc	164	24	proportion	proportion	NN
cord-003302-vxk7uqlc	164	25	died	die	VBD
cord-003302-vxk7uqlc	164	26	.	.	.
cord-003302-vxk7uqlc	165	1	Some	some	DT
cord-003302-vxk7uqlc	165	2	of	of	IN
cord-003302-vxk7uqlc	165	3	this	this	DT
cord-003302-vxk7uqlc	165	4	protection	protection	NN
cord-003302-vxk7uqlc	165	5	is	be	VBZ
cord-003302-vxk7uqlc	165	6	due	due	JJ
cord-003302-vxk7uqlc	165	7	to	to	IN
cord-003302-vxk7uqlc	165	8	CD8	CD8	NNP
cord-003302-vxk7uqlc	165	9	+	+	CC
cord-003302-vxk7uqlc	165	10	T	t	NN
cord-003302-vxk7uqlc	165	11	-	-	HYPH
cord-003302-vxk7uqlc	165	12	cell	cell	NN
cord-003302-vxk7uqlc	165	13	immunity	immunity	NN
cord-003302-vxk7uqlc	165	14	,	,	,
cord-003302-vxk7uqlc	165	15	especially	especially	RB
cord-003302-vxk7uqlc	165	16	immunity	immunity	NN
cord-003302-vxk7uqlc	165	17	directed	direct	VBN
cord-003302-vxk7uqlc	165	18	against	against	IN
cord-003302-vxk7uqlc	165	19	the	the	DT
cord-003302-vxk7uqlc	165	20	evolutionarily	evolutionarily	RB
cord-003302-vxk7uqlc	165	21	conserved	conserved	JJ
cord-003302-vxk7uqlc	165	22	NP	NP	NNP
cord-003302-vxk7uqlc	165	23	antigen	antigen	NN
cord-003302-vxk7uqlc	165	24	[	[	-LRB-
cord-003302-vxk7uqlc	165	25	53	53	CD
cord-003302-vxk7uqlc	165	26	]	]	-RRB-
cord-003302-vxk7uqlc	165	27	.	.	.
cord-003302-vxk7uqlc	166	1	This	this	DT
cord-003302-vxk7uqlc	166	2	immunity	immunity	NN
cord-003302-vxk7uqlc	166	3	reflects	reflect	VBZ
cord-003302-vxk7uqlc	166	4	previous	previous	JJ
cord-003302-vxk7uqlc	166	5	exposure	exposure	NN
cord-003302-vxk7uqlc	166	6	of	of	IN
cord-003302-vxk7uqlc	166	7	populations	population	NNS
cord-003302-vxk7uqlc	166	8	to	to	IN
cord-003302-vxk7uqlc	166	9	influenza	influenza	NN
cord-003302-vxk7uqlc	166	10	virus	virus	NN
cord-003302-vxk7uqlc	166	11	antigens	antigen	NNS
cord-003302-vxk7uqlc	166	12	,	,	,
cord-003302-vxk7uqlc	166	13	but	but	CC
cord-003302-vxk7uqlc	166	14	importantly	importantly	RB
cord-003302-vxk7uqlc	166	15	it	-PRON-	PRP
cord-003302-vxk7uqlc	166	16	encompasses	encompass	VBZ
cord-003302-vxk7uqlc	166	17	both	both	CC
cord-003302-vxk7uqlc	166	18	Group	Group	NNP
cord-003302-vxk7uqlc	166	19	1	1	CD
cord-003302-vxk7uqlc	166	20	and	and	CC
cord-003302-vxk7uqlc	166	21	Group	Group	NNP
cord-003302-vxk7uqlc	166	22	2	2	CD
cord-003302-vxk7uqlc	166	23	viruses	virus	NNS
cord-003302-vxk7uqlc	166	24	,	,	,
cord-003302-vxk7uqlc	166	25	unlike	unlike	IN
cord-003302-vxk7uqlc	166	26	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	166	27	imprinting	imprinting	NN
cord-003302-vxk7uqlc	166	28	discussed	discuss	VBN
cord-003302-vxk7uqlc	166	29	above	above	RB
cord-003302-vxk7uqlc	166	30	.	.	.
cord-003302-vxk7uqlc	167	1	T	t	NN
cord-003302-vxk7uqlc	167	2	-	-	HYPH
cord-003302-vxk7uqlc	167	3	cell	cell	NN
cord-003302-vxk7uqlc	167	4	immunity	immunity	NN
cord-003302-vxk7uqlc	167	5	does	do	VBZ
cord-003302-vxk7uqlc	167	6	not	not	RB
cord-003302-vxk7uqlc	167	7	prevent	prevent	VB
cord-003302-vxk7uqlc	167	8	the	the	DT
cord-003302-vxk7uqlc	167	9	occurrence	occurrence	NN
cord-003302-vxk7uqlc	167	10	of	of	IN
cord-003302-vxk7uqlc	167	11	infection	infection	NN
cord-003302-vxk7uqlc	167	12	,	,	,
cord-003302-vxk7uqlc	167	13	but	but	CC
cord-003302-vxk7uqlc	167	14	it	-PRON-	PRP
cord-003302-vxk7uqlc	167	15	modifies	modify	VBZ
cord-003302-vxk7uqlc	167	16	the	the	DT
cord-003302-vxk7uqlc	167	17	course	course	NN
cord-003302-vxk7uqlc	167	18	of	of	IN
cord-003302-vxk7uqlc	167	19	illness	illness	NN
cord-003302-vxk7uqlc	167	20	,	,	,
cord-003302-vxk7uqlc	167	21	reducing	reduce	VBG
cord-003302-vxk7uqlc	167	22	virus	virus	NN
cord-003302-vxk7uqlc	167	23	shedding	shed	VBG
cord-003302-vxk7uqlc	167	24	and	and	CC
cord-003302-vxk7uqlc	167	25	in	in	IN
cord-003302-vxk7uqlc	167	26	some	some	DT
cord-003302-vxk7uqlc	167	27	instances	instance	NNS
cord-003302-vxk7uqlc	167	28	limiting	limit	VBG
cord-003302-vxk7uqlc	167	29	or	or	CC
cord-003302-vxk7uqlc	167	30	preventing	prevent	VBG
cord-003302-vxk7uqlc	167	31	the	the	DT
cord-003302-vxk7uqlc	167	32	occurrence	occurrence	NN
cord-003302-vxk7uqlc	167	33	of	of	IN
cord-003302-vxk7uqlc	167	34	symptoms	symptom	NNS
cord-003302-vxk7uqlc	167	35	[	[	-LRB-
cord-003302-vxk7uqlc	167	36	53	53	CD
cord-003302-vxk7uqlc	167	37	]	]	-RRB-
cord-003302-vxk7uqlc	167	38	.	.	.
cord-003302-vxk7uqlc	168	1	Inborn	inborn	JJ
cord-003302-vxk7uqlc	168	2	genetic	genetic	JJ
cord-003302-vxk7uqlc	168	3	variants	variant	NNS
cord-003302-vxk7uqlc	168	4	can	can	MD
cord-003302-vxk7uqlc	168	5	also	also	RB
cord-003302-vxk7uqlc	168	6	account	account	VB
cord-003302-vxk7uqlc	168	7	for	for	IN
cord-003302-vxk7uqlc	168	8	life	life	NN
cord-003302-vxk7uqlc	168	9	-	-	HYPH
cord-003302-vxk7uqlc	168	10	threatening	threaten	VBG
cord-003302-vxk7uqlc	168	11	infections	infection	NNS
cord-003302-vxk7uqlc	168	12	[	[	-LRB-
cord-003302-vxk7uqlc	168	13	54	54	CD
cord-003302-vxk7uqlc	168	14	]	]	-RRB-
cord-003302-vxk7uqlc	168	15	,	,	,
cord-003302-vxk7uqlc	168	16	but	but	CC
cord-003302-vxk7uqlc	168	17	the	the	DT
cord-003302-vxk7uqlc	168	18	susceptibility	susceptibility	NN
cord-003302-vxk7uqlc	168	19	of	of	IN
cord-003302-vxk7uqlc	168	20	most	most	JJS
cord-003302-vxk7uqlc	168	21	individuals	individual	NNS
cord-003302-vxk7uqlc	168	22	probably	probably	RB
cord-003302-vxk7uqlc	168	23	depends	depend	VBZ
cord-003302-vxk7uqlc	168	24	more	more	RBR
cord-003302-vxk7uqlc	168	25	on	on	IN
cord-003302-vxk7uqlc	168	26	variations	variation	NNS
cord-003302-vxk7uqlc	168	27	in	in	IN
cord-003302-vxk7uqlc	168	28	host	host	NN
cord-003302-vxk7uqlc	168	29	defense	defense	NN
cord-003302-vxk7uqlc	168	30	mechanisms	mechanism	NNS
cord-003302-vxk7uqlc	168	31	that	that	WDT
cord-003302-vxk7uqlc	168	32	are	be	VBP
cord-003302-vxk7uqlc	168	33	expressed	express	VBN
cord-003302-vxk7uqlc	168	34	only	only	RB
cord-003302-vxk7uqlc	168	35	after	after	IN
cord-003302-vxk7uqlc	168	36	infection	infection	NN
cord-003302-vxk7uqlc	168	37	has	have	VBZ
cord-003302-vxk7uqlc	168	38	occurred	occur	VBN
cord-003302-vxk7uqlc	168	39	[	[	-LRB-
cord-003302-vxk7uqlc	168	40	53	53	CD
cord-003302-vxk7uqlc	168	41	,	,	,
cord-003302-vxk7uqlc	168	42	55	55	CD
cord-003302-vxk7uqlc	168	43	]	]	-RRB-
cord-003302-vxk7uqlc	168	44	.	.	.
cord-003302-vxk7uqlc	169	1	The	the	DT
cord-003302-vxk7uqlc	169	2	importance	importance	NN
cord-003302-vxk7uqlc	169	3	of	of	IN
cord-003302-vxk7uqlc	169	4	these	these	DT
cord-003302-vxk7uqlc	169	5	post	post	JJ
cord-003302-vxk7uqlc	169	6	-	-	JJ
cord-003302-vxk7uqlc	169	7	infection	infection	JJ
cord-003302-vxk7uqlc	169	8	variations	variation	NNS
cord-003302-vxk7uqlc	169	9	was	be	VBD
cord-003302-vxk7uqlc	169	10	demonstrated	demonstrate	VBN
cord-003302-vxk7uqlc	169	11	in	in	IN
cord-003302-vxk7uqlc	169	12	25	25	CD
cord-003302-vxk7uqlc	169	13	HA	HA	NNP
cord-003302-vxk7uqlc	169	14	-	-	HYPH
cord-003302-vxk7uqlc	169	15	seronegative	seronegative	JJ
cord-003302-vxk7uqlc	169	16	healthy	healthy	JJ
cord-003302-vxk7uqlc	169	17	young	young	JJ
cord-003302-vxk7uqlc	169	18	adults	adult	NNS
cord-003302-vxk7uqlc	169	19	who	who	WP
cord-003302-vxk7uqlc	169	20	were	be	VBD
cord-003302-vxk7uqlc	169	21	experimentally	experimentally	RB
cord-003302-vxk7uqlc	169	22	infected	infect	VBN
cord-003302-vxk7uqlc	169	23	with	with	IN
cord-003302-vxk7uqlc	169	24	influenza	influenza	NN
cord-003302-vxk7uqlc	169	25	H3N2	H3N2	NNP
cord-003302-vxk7uqlc	169	26	virus	virus	NN
cord-003302-vxk7uqlc	169	27	[	[	-LRB-
cord-003302-vxk7uqlc	169	28	56	56	CD
cord-003302-vxk7uqlc	169	29	]	]	-RRB-
cord-003302-vxk7uqlc	169	30	.	.	.
cord-003302-vxk7uqlc	170	1	(	(	-LRB-
cord-003302-vxk7uqlc	170	2	A	a	DT
cord-003302-vxk7uqlc	170	3	similar	similar	JJ
cord-003302-vxk7uqlc	170	4	study	study	NN
cord-003302-vxk7uqlc	170	5	was	be	VBD
cord-003302-vxk7uqlc	170	6	undertaken	undertake	VBN
cord-003302-vxk7uqlc	170	7	with	with	IN
cord-003302-vxk7uqlc	170	8	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	170	9	challenge	challenge	NN
cord-003302-vxk7uqlc	170	10	infection	infection	NN
cord-003302-vxk7uqlc	170	11	[	[	-LRB-
cord-003302-vxk7uqlc	170	12	57	57	CD
cord-003302-vxk7uqlc	170	13	]	]	-RRB-
cord-003302-vxk7uqlc	170	14	.	.	.
cord-003302-vxk7uqlc	170	15	)	)	-RRB-
cord-003302-vxk7uqlc	171	1	Following	follow	VBG
cord-003302-vxk7uqlc	171	2	infection	infection	NN
cord-003302-vxk7uqlc	171	3	,	,	,
cord-003302-vxk7uqlc	171	4	peripheral	peripheral	JJ
cord-003302-vxk7uqlc	171	5	blood	blood	NN
cord-003302-vxk7uqlc	171	6	cytokine	cytokine	NN
cord-003302-vxk7uqlc	171	7	responses	response	NNS
cord-003302-vxk7uqlc	171	8	were	be	VBD
cord-003302-vxk7uqlc	171	9	determined	determine	VBN
cord-003302-vxk7uqlc	171	10	every	every	DT
cord-003302-vxk7uqlc	171	11	six	six	CD
cord-003302-vxk7uqlc	171	12	hours	hour	NNS
cord-003302-vxk7uqlc	171	13	for	for	IN
cord-003302-vxk7uqlc	171	14	the	the	DT
cord-003302-vxk7uqlc	171	15	next	next	JJ
cord-003302-vxk7uqlc	171	16	five	five	CD
cord-003302-vxk7uqlc	171	17	days	day	NNS
cord-003302-vxk7uqlc	171	18	.	.	.
cord-003302-vxk7uqlc	172	1	In	in	IN
cord-003302-vxk7uqlc	172	2	nine	nine	CD
cord-003302-vxk7uqlc	172	3	subjects	subject	NNS
cord-003302-vxk7uqlc	172	4	who	who	WP
cord-003302-vxk7uqlc	172	5	developed	develop	VBD
cord-003302-vxk7uqlc	172	6	symptomatic	symptomatic	JJ
cord-003302-vxk7uqlc	172	7	illness	illness	NN
cord-003302-vxk7uqlc	172	8	,	,	,
cord-003302-vxk7uqlc	172	9	there	there	EX
cord-003302-vxk7uqlc	172	10	were	be	VBD
cord-003302-vxk7uqlc	172	11	early	early	JJ
cord-003302-vxk7uqlc	172	12	increases	increase	NNS
cord-003302-vxk7uqlc	172	13	in	in	IN
cord-003302-vxk7uqlc	172	14	cytokines	cytokine	NNS
cord-003302-vxk7uqlc	172	15	associated	associate	VBN
cord-003302-vxk7uqlc	172	16	with	with	IN
cord-003302-vxk7uqlc	172	17	fever	fever	NN
cord-003302-vxk7uqlc	172	18	,	,	,
cord-003302-vxk7uqlc	172	19	leucocyte	leucocyte	NNP
cord-003302-vxk7uqlc	172	20	recruitment	recruitment	NN
cord-003302-vxk7uqlc	172	21	and	and	CC
cord-003302-vxk7uqlc	172	22	markers	marker	NNS
cord-003302-vxk7uqlc	172	23	of	of	IN
cord-003302-vxk7uqlc	172	24	innate	innate	JJ
cord-003302-vxk7uqlc	172	25	antiviral	antiviral	JJ
cord-003302-vxk7uqlc	172	26	immunity	immunity	NN
cord-003302-vxk7uqlc	172	27	,	,	,
cord-003302-vxk7uqlc	172	28	and	and	CC
cord-003302-vxk7uqlc	172	29	some	some	DT
cord-003302-vxk7uqlc	172	30	of	of	IN
cord-003302-vxk7uqlc	172	31	these	these	DT
cord-003302-vxk7uqlc	172	32	increases	increase	NNS
cord-003302-vxk7uqlc	172	33	appeared	appear	VBD
cord-003302-vxk7uqlc	172	34	as	as	RB
cord-003302-vxk7uqlc	172	35	early	early	RB
cord-003302-vxk7uqlc	172	36	as	as	IN
cord-003302-vxk7uqlc	172	37	two	two	CD
cord-003302-vxk7uqlc	172	38	days	day	NNS
cord-003302-vxk7uqlc	172	39	before	before	IN
cord-003302-vxk7uqlc	172	40	the	the	DT
cord-003302-vxk7uqlc	172	41	onset	onset	NN
cord-003302-vxk7uqlc	172	42	of	of	IN
cord-003302-vxk7uqlc	172	43	symptoms	symptom	NNS
cord-003302-vxk7uqlc	172	44	[	[	-LRB-
cord-003302-vxk7uqlc	172	45	56	56	CD
cord-003302-vxk7uqlc	172	46	]	]	-RRB-
cord-003302-vxk7uqlc	172	47	.	.	.
cord-003302-vxk7uqlc	173	1	These	these	DT
cord-003302-vxk7uqlc	173	2	cytokine	cytokine	NN
cord-003302-vxk7uqlc	173	3	findings	finding	NNS
cord-003302-vxk7uqlc	173	4	were	be	VBD
cord-003302-vxk7uqlc	173	5	also	also	RB
cord-003302-vxk7uqlc	173	6	demonstrated	demonstrate	VBN
cord-003302-vxk7uqlc	173	7	in	in	IN
cord-003302-vxk7uqlc	173	8	a	a	DT
cord-003302-vxk7uqlc	173	9	parallel	parallel	JJ
cord-003302-vxk7uqlc	173	10	genomic	genomic	JJ
cord-003302-vxk7uqlc	173	11	analysis	analysis	NN
cord-003302-vxk7uqlc	173	12	.	.	.
cord-003302-vxk7uqlc	174	1	In	in	IN
cord-003302-vxk7uqlc	174	2	contrast	contrast	NN
cord-003302-vxk7uqlc	174	3	,	,	,
cord-003302-vxk7uqlc	174	4	the	the	DT
cord-003302-vxk7uqlc	174	5	17	17	CD
cord-003302-vxk7uqlc	174	6	subjects	subject	NNS
cord-003302-vxk7uqlc	174	7	who	who	WP
cord-003302-vxk7uqlc	174	8	remained	remain	VBD
cord-003302-vxk7uqlc	174	9	asymptomatic	asymptomatic	JJ
cord-003302-vxk7uqlc	174	10	showed	show	VBD
cord-003302-vxk7uqlc	174	11	early	early	JJ
cord-003302-vxk7uqlc	174	12	and	and	CC
cord-003302-vxk7uqlc	174	13	persistent	persistent	JJ
cord-003302-vxk7uqlc	174	14	down	down	RP
cord-003302-vxk7uqlc	174	15	regulation	regulation	NN
cord-003302-vxk7uqlc	174	16	of	of	IN
cord-003302-vxk7uqlc	174	17	the	the	DT
cord-003302-vxk7uqlc	174	18	same	same	JJ
cord-003302-vxk7uqlc	174	19	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	174	20	markers	marker	NNS
cord-003302-vxk7uqlc	174	21	.	.	.
cord-003302-vxk7uqlc	175	1	Symptomatic	symptomatic	JJ
cord-003302-vxk7uqlc	175	2	subjects	subject	NNS
cord-003302-vxk7uqlc	175	3	developed	develop	VBD
cord-003302-vxk7uqlc	175	4	cytokine	cytokine	NN
cord-003302-vxk7uqlc	175	5	profiles	profile	NNS
cord-003302-vxk7uqlc	175	6	similar	similar	JJ
cord-003302-vxk7uqlc	175	7	to	to	IN
cord-003302-vxk7uqlc	175	8	those	those	DT
cord-003302-vxk7uqlc	175	9	that	that	WDT
cord-003302-vxk7uqlc	175	10	have	have	VBP
cord-003302-vxk7uqlc	175	11	been	be	VBN
cord-003302-vxk7uqlc	175	12	seen	see	VBN
cord-003302-vxk7uqlc	175	13	in	in	IN
cord-003302-vxk7uqlc	175	14	patients	patient	NNS
cord-003302-vxk7uqlc	175	15	who	who	WP
cord-003302-vxk7uqlc	175	16	develop	develop	VBP
cord-003302-vxk7uqlc	175	17	severe	severe	JJ
cord-003302-vxk7uqlc	175	18	illness	illness	NN
cord-003302-vxk7uqlc	175	19	,	,	,
cord-003302-vxk7uqlc	175	20	while	while	IN
cord-003302-vxk7uqlc	175	21	those	those	DT
cord-003302-vxk7uqlc	175	22	who	who	WP
cord-003302-vxk7uqlc	175	23	remained	remain	VBD
cord-003302-vxk7uqlc	175	24	asymptomatic	asymptomatic	JJ
cord-003302-vxk7uqlc	175	25	showed	show	VBD
cord-003302-vxk7uqlc	175	26	host	host	NN
cord-003302-vxk7uqlc	175	27	responses	response	NNS
cord-003302-vxk7uqlc	175	28	indicating	indicate	VBG
cord-003302-vxk7uqlc	175	29	rapid	rapid	JJ
cord-003302-vxk7uqlc	175	30	control	control	NN
cord-003302-vxk7uqlc	175	31	of	of	IN
cord-003302-vxk7uqlc	175	32	infection	infection	NN
cord-003302-vxk7uqlc	175	33	.	.	.
cord-003302-vxk7uqlc	176	1	These	these	DT
cord-003302-vxk7uqlc	176	2	findings	finding	NNS
cord-003302-vxk7uqlc	176	3	suggested	suggest	VBD
cord-003302-vxk7uqlc	176	4	that	that	IN
cord-003302-vxk7uqlc	176	5	the	the	DT
cord-003302-vxk7uqlc	176	6	"	"	``
cord-003302-vxk7uqlc	176	7	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	176	8	pathway	pathway	NN
cord-003302-vxk7uqlc	176	9	an	an	DT
cord-003302-vxk7uqlc	176	10	individual	individual	NN
cord-003302-vxk7uqlc	176	11	will	will	MD
cord-003302-vxk7uqlc	176	12	follow	follow	VB
cord-003302-vxk7uqlc	176	13	is	be	VBZ
cord-003302-vxk7uqlc	176	14	probably	probably	RB
cord-003302-vxk7uqlc	176	15	determined	determined	JJ
cord-003302-vxk7uqlc	176	16	at	at	IN
cord-003302-vxk7uqlc	176	17	(	(	-LRB-
cord-003302-vxk7uqlc	176	18	a	a	DT
cord-003302-vxk7uqlc	176	19	)	)	-RRB-
cord-003302-vxk7uqlc	176	20	very	very	RB
cord-003302-vxk7uqlc	176	21	early	early	JJ
cord-003302-vxk7uqlc	176	22	,	,	,
cord-003302-vxk7uqlc	176	23	even	even	RB
cord-003302-vxk7uqlc	176	24	presymptomatic	presymptomatic	JJ
cord-003302-vxk7uqlc	176	25	time	time	NN
cord-003302-vxk7uqlc	176	26	"	"	''
cord-003302-vxk7uqlc	176	27	[	[	-LRB-
cord-003302-vxk7uqlc	176	28	56	56	CD
cord-003302-vxk7uqlc	176	29	]	]	-RRB-
cord-003302-vxk7uqlc	176	30	.	.	.
cord-003302-vxk7uqlc	177	1	Which	which	WDT
cord-003302-vxk7uqlc	177	2	pathway	pathway	NN
cord-003302-vxk7uqlc	177	3	is	be	VBZ
cord-003302-vxk7uqlc	177	4	followed	follow	VBN
cord-003302-vxk7uqlc	177	5	is	be	VBZ
cord-003302-vxk7uqlc	177	6	probably	probably	RB
cord-003302-vxk7uqlc	177	7	determined	determined	JJ
cord-003302-vxk7uqlc	177	8	(	(	-LRB-
cord-003302-vxk7uqlc	177	9	at	at	IN
cord-003302-vxk7uqlc	177	10	least	least	JJS
cord-003302-vxk7uqlc	177	11	in	in	IN
cord-003302-vxk7uqlc	177	12	part	part	NN
cord-003302-vxk7uqlc	177	13	)	)	-RRB-
cord-003302-vxk7uqlc	177	14	by	by	IN
cord-003302-vxk7uqlc	177	15	epigenetic	epigenetic	JJ
cord-003302-vxk7uqlc	177	16	factors	factor	NNS
cord-003302-vxk7uqlc	177	17	[	[	-LRB-
cord-003302-vxk7uqlc	177	18	58	58	CD
cord-003302-vxk7uqlc	177	19	]	]	-RRB-
cord-003302-vxk7uqlc	177	20	[	[	-LRB-
cord-003302-vxk7uqlc	177	21	59	59	CD
cord-003302-vxk7uqlc	177	22	]	]	-RRB-
cord-003302-vxk7uqlc	177	23	[	[	-LRB-
cord-003302-vxk7uqlc	177	24	60	60	CD
cord-003302-vxk7uqlc	177	25	]	]	-RRB-
cord-003302-vxk7uqlc	177	26	.	.	.
cord-003302-vxk7uqlc	178	1	In	in	IN
cord-003302-vxk7uqlc	178	2	a	a	DT
cord-003302-vxk7uqlc	178	3	study	study	NN
cord-003302-vxk7uqlc	178	4	of	of	IN
cord-003302-vxk7uqlc	178	5	populations	population	NNS
cord-003302-vxk7uqlc	178	6	in	in	IN
cord-003302-vxk7uqlc	178	7	Sweden	Sweden	NNP
cord-003302-vxk7uqlc	178	8	and	and	CC
cord-003302-vxk7uqlc	178	9	Japan	Japan	NNP
cord-003302-vxk7uqlc	178	10	during	during	IN
cord-003302-vxk7uqlc	178	11	the	the	DT
cord-003302-vxk7uqlc	178	12	early	early	JJ
cord-003302-vxk7uqlc	178	13	and	and	CC
cord-003302-vxk7uqlc	178	14	late	late	JJ
cord-003302-vxk7uqlc	178	15	years	year	NNS
cord-003302-vxk7uqlc	178	16	of	of	IN
cord-003302-vxk7uqlc	178	17	the	the	DT
cord-003302-vxk7uqlc	178	18	20	20	CD
cord-003302-vxk7uqlc	178	19	th	th	XX
cord-003302-vxk7uqlc	178	20	century	century	NN
cord-003302-vxk7uqlc	178	21	,	,	,
cord-003302-vxk7uqlc	178	22	evolutionary	evolutionary	JJ
cord-003302-vxk7uqlc	178	23	biologists	biologist	NNS
cord-003302-vxk7uqlc	178	24	showed	show	VBD
cord-003302-vxk7uqlc	178	25	that	that	IN
cord-003302-vxk7uqlc	178	26	the	the	DT
cord-003302-vxk7uqlc	178	27	increase	increase	NN
cord-003302-vxk7uqlc	178	28	in	in	IN
cord-003302-vxk7uqlc	178	29	the	the	DT
cord-003302-vxk7uqlc	178	30	annual	annual	JJ
cord-003302-vxk7uqlc	178	31	probability	probability	NN
cord-003302-vxk7uqlc	178	32	of	of	IN
cord-003302-vxk7uqlc	178	33	death	death	NN
cord-003302-vxk7uqlc	178	34	due	due	IN
cord-003302-vxk7uqlc	178	35	to	to	IN
cord-003302-vxk7uqlc	178	36	all	all	DT
cord-003302-vxk7uqlc	178	37	causes	cause	NNS
cord-003302-vxk7uqlc	178	38	was	be	VBD
cord-003302-vxk7uqlc	178	39	greatest	great	JJS
cord-003302-vxk7uqlc	178	40	during	during	IN
cord-003302-vxk7uqlc	178	41	the	the	DT
cord-003302-vxk7uqlc	178	42	second	second	JJ
cord-003302-vxk7uqlc	178	43	decade	decade	NN
cord-003302-vxk7uqlc	178	44	of	of	IN
cord-003302-vxk7uqlc	178	45	life	life	NN
cord-003302-vxk7uqlc	178	46	,	,	,
cord-003302-vxk7uqlc	178	47	not	not	RB
cord-003302-vxk7uqlc	178	48	in	in	IN
cord-003302-vxk7uqlc	178	49	later	later	JJ
cord-003302-vxk7uqlc	178	50	years	year	NNS
cord-003302-vxk7uqlc	178	51	(	(	-LRB-
cord-003302-vxk7uqlc	178	52	Fig	Fig	NNP
cord-003302-vxk7uqlc	178	53	.	.	.
cord-003302-vxk7uqlc	178	54	4	4	LS
cord-003302-vxk7uqlc	178	55	)	)	-RRB-
cord-003302-vxk7uqlc	178	56	[	[	-LRB-
cord-003302-vxk7uqlc	178	57	61	61	CD
cord-003302-vxk7uqlc	178	58	]	]	-RRB-
cord-003302-vxk7uqlc	178	59	.	.	.
cord-003302-vxk7uqlc	179	1	Other	other	JJ
cord-003302-vxk7uqlc	179	2	studies	study	NNS
cord-003302-vxk7uqlc	179	3	have	have	VBP
cord-003302-vxk7uqlc	179	4	shown	show	VBN
cord-003302-vxk7uqlc	179	5	that	that	IN
cord-003302-vxk7uqlc	179	6	stress	stress	NN
cord-003302-vxk7uqlc	179	7	differentially	differentially	RB
cord-003302-vxk7uqlc	179	8	allocates	allocate	VBZ
cord-003302-vxk7uqlc	179	9	energy	energy	NN
cord-003302-vxk7uqlc	179	10	resources	resource	NNS
cord-003302-vxk7uqlc	179	11	between	between	IN
cord-003302-vxk7uqlc	179	12	reproduction	reproduction	NN
cord-003302-vxk7uqlc	179	13	and	and	CC
cord-003302-vxk7uqlc	179	14	immune	immune	JJ
cord-003302-vxk7uqlc	179	15	function	function	NN
cord-003302-vxk7uqlc	179	16	[	[	-LRB-
cord-003302-vxk7uqlc	179	17	62	62	CD
cord-003302-vxk7uqlc	179	18	]	]	-RRB-
cord-003302-vxk7uqlc	179	19	,	,	,
cord-003302-vxk7uqlc	179	20	and	and	CC
cord-003302-vxk7uqlc	179	21	estrogens	estrogen	NNS
cord-003302-vxk7uqlc	179	22	contribute	contribute	VBP
cord-003302-vxk7uqlc	179	23	to	to	IN
cord-003302-vxk7uqlc	179	24	the	the	DT
cord-003302-vxk7uqlc	179	25	energy	energy	NN
cord-003302-vxk7uqlc	179	26	trade	trade	NN
cord-003302-vxk7uqlc	179	27	-	-	HYPH
cord-003302-vxk7uqlc	179	28	offs	off	NNS
cord-003302-vxk7uqlc	179	29	that	that	WDT
cord-003302-vxk7uqlc	179	30	help	help	VBP
cord-003302-vxk7uqlc	179	31	maintain	maintain	VB
cord-003302-vxk7uqlc	179	32	homeostasis	homeostasis	NN
cord-003302-vxk7uqlc	179	33	[	[	-LRB-
cord-003302-vxk7uqlc	179	34	52	52	CD
cord-003302-vxk7uqlc	179	35	,	,	,
cord-003302-vxk7uqlc	179	36	63	63	CD
cord-003302-vxk7uqlc	179	37	]	]	-RRB-
cord-003302-vxk7uqlc	179	38	.	.	.
cord-003302-vxk7uqlc	180	1	At	at	IN
cord-003302-vxk7uqlc	180	2	least	least	JJS
cord-003302-vxk7uqlc	180	3	some	some	DT
cord-003302-vxk7uqlc	180	4	of	of	IN
cord-003302-vxk7uqlc	180	5	the	the	DT
cord-003302-vxk7uqlc	180	6	mechanisms	mechanism	NNS
cord-003302-vxk7uqlc	180	7	responsible	responsible	JJ
cord-003302-vxk7uqlc	180	8	for	for	IN
cord-003302-vxk7uqlc	180	9	maintaining	maintain	VBG
cord-003302-vxk7uqlc	180	10	homeostasis	homeostasis	NN
cord-003302-vxk7uqlc	180	11	during	during	IN
cord-003302-vxk7uqlc	180	12	puberty	puberty	NN
cord-003302-vxk7uqlc	180	13	are	be	VBP
cord-003302-vxk7uqlc	180	14	epigenetically	epigenetically	RB
cord-003302-vxk7uqlc	180	15	regulated	regulate	VBN
cord-003302-vxk7uqlc	180	16	[	[	-LRB-
cord-003302-vxk7uqlc	180	17	64	64	CD
cord-003302-vxk7uqlc	180	18	]	]	-RRB-
cord-003302-vxk7uqlc	180	19	.	.	.
cord-003302-vxk7uqlc	181	1	Numerous	numerous	JJ
cord-003302-vxk7uqlc	181	2	laboratory	laboratory	NN
cord-003302-vxk7uqlc	181	3	and	and	CC
cord-003302-vxk7uqlc	181	4	clinical	clinical	JJ
cord-003302-vxk7uqlc	181	5	studies	study	NNS
cord-003302-vxk7uqlc	181	6	have	have	VBP
cord-003302-vxk7uqlc	181	7	described	describe	VBN
cord-003302-vxk7uqlc	181	8	biological	biological	JJ
cord-003302-vxk7uqlc	181	9	pathways	pathway	NNS
cord-003302-vxk7uqlc	181	10	that	that	WDT
cord-003302-vxk7uqlc	181	11	are	be	VBP
cord-003302-vxk7uqlc	181	12	associated	associate	VBN
cord-003302-vxk7uqlc	181	13	with	with	IN
cord-003302-vxk7uqlc	181	14	the	the	DT
cord-003302-vxk7uqlc	181	15	susceptibility	susceptibility	NN
cord-003302-vxk7uqlc	181	16	of	of	IN
cord-003302-vxk7uqlc	181	17	neonates	neonate	NNS
cord-003302-vxk7uqlc	181	18	and	and	CC
cord-003302-vxk7uqlc	181	19	the	the	DT
cord-003302-vxk7uqlc	181	20	elderly	elderly	JJ
cord-003302-vxk7uqlc	181	21	to	to	TO
cord-003302-vxk7uqlc	181	22	acute	acute	VB
cord-003302-vxk7uqlc	181	23	critical	critical	JJ
cord-003302-vxk7uqlc	181	24	illnesses	illness	NNS
cord-003302-vxk7uqlc	181	25	,	,	,
cord-003302-vxk7uqlc	181	26	but	but	CC
cord-003302-vxk7uqlc	181	27	very	very	RB
cord-003302-vxk7uqlc	181	28	few	few	JJ
cord-003302-vxk7uqlc	181	29	studies	study	NNS
cord-003302-vxk7uqlc	181	30	have	have	VBP
cord-003302-vxk7uqlc	181	31	compared	compare	VBN
cord-003302-vxk7uqlc	181	32	host	host	NN
cord-003302-vxk7uqlc	181	33	responses	response	NNS
cord-003302-vxk7uqlc	181	34	before	before	IN
cord-003302-vxk7uqlc	181	35	and	and	CC
cord-003302-vxk7uqlc	181	36	after	after	IN
cord-003302-vxk7uqlc	181	37	puberty	puberty	NN
cord-003302-vxk7uqlc	181	38	[	[	-LRB-
cord-003302-vxk7uqlc	181	39	65	65	CD
cord-003302-vxk7uqlc	181	40	,	,	,
cord-003302-vxk7uqlc	181	41	66	66	CD
cord-003302-vxk7uqlc	181	42	]	]	-RRB-
cord-003302-vxk7uqlc	181	43	.	.	.
cord-003302-vxk7uqlc	182	1	One	one	CD
cord-003302-vxk7uqlc	182	2	such	such	JJ
cord-003302-vxk7uqlc	182	3	study	study	NN
cord-003302-vxk7uqlc	182	4	documented	document	VBD
cord-003302-vxk7uqlc	182	5	the	the	DT
cord-003302-vxk7uqlc	182	6	responses	response	NNS
cord-003302-vxk7uqlc	182	7	of	of	IN
cord-003302-vxk7uqlc	182	8	weanling	weanle	VBG
cord-003302-vxk7uqlc	182	9	and	and	CC
cord-003302-vxk7uqlc	182	10	adult	adult	NN
cord-003302-vxk7uqlc	182	11	ferrets	ferret	NNS
cord-003302-vxk7uqlc	182	12	following	follow	VBG
cord-003302-vxk7uqlc	182	13	infection	infection	NN
cord-003302-vxk7uqlc	182	14	with	with	IN
cord-003302-vxk7uqlc	182	15	the	the	DT
cord-003302-vxk7uqlc	182	16	2009	2009	CD
cord-003302-vxk7uqlc	182	17	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	182	18	pandemic	pandemic	NN
cord-003302-vxk7uqlc	182	19	virus	virus	NN
cord-003302-vxk7uqlc	182	20	[	[	-LRB-
cord-003302-vxk7uqlc	182	21	65	65	CD
cord-003302-vxk7uqlc	182	22	]	]	-RRB-
cord-003302-vxk7uqlc	182	23	.	.	.
cord-003302-vxk7uqlc	183	1	Compared	compare	VBN
cord-003302-vxk7uqlc	183	2	with	with	IN
cord-003302-vxk7uqlc	183	3	adult	adult	NN
cord-003302-vxk7uqlc	183	4	ferrets	ferret	NNS
cord-003302-vxk7uqlc	183	5	,	,	,
cord-003302-vxk7uqlc	183	6	weanlings	weanling	NNS
cord-003302-vxk7uqlc	183	7	developed	develop	VBD
cord-003302-vxk7uqlc	183	8	much	much	RB
cord-003302-vxk7uqlc	183	9	milder	mild	JJR
cord-003302-vxk7uqlc	183	10	clinical	clinical	JJ
cord-003302-vxk7uqlc	183	11	illnesses	illness	NNS
cord-003302-vxk7uqlc	183	12	and	and	CC
cord-003302-vxk7uqlc	183	13	had	have	VBD
cord-003302-vxk7uqlc	183	14	less	less	JJR
cord-003302-vxk7uqlc	183	15	evidence	evidence	NN
cord-003302-vxk7uqlc	183	16	of	of	IN
cord-003302-vxk7uqlc	183	17	pulmonary	pulmonary	JJ
cord-003302-vxk7uqlc	183	18	damage	damage	NN
cord-003302-vxk7uqlc	183	19	,	,	,
cord-003302-vxk7uqlc	183	20	yet	yet	CC
cord-003302-vxk7uqlc	183	21	rapid	rapid	JJ
cord-003302-vxk7uqlc	183	22	virus	virus	NN
cord-003302-vxk7uqlc	183	23	clearance	clearance	NN
cord-003302-vxk7uqlc	183	24	from	from	IN
cord-003302-vxk7uqlc	183	25	the	the	DT
cord-003302-vxk7uqlc	183	26	respiratory	respiratory	JJ
cord-003302-vxk7uqlc	183	27	tract	tract	NN
cord-003302-vxk7uqlc	183	28	was	be	VBD
cord-003302-vxk7uqlc	183	29	seen	see	VBN
cord-003302-vxk7uqlc	183	30	in	in	IN
cord-003302-vxk7uqlc	183	31	both	both	DT
cord-003302-vxk7uqlc	183	32	groups	group	NNS
cord-003302-vxk7uqlc	183	33	.	.	.
cord-003302-vxk7uqlc	184	1	Like	like	IN
cord-003302-vxk7uqlc	184	2	adults	adult	NNS
cord-003302-vxk7uqlc	184	3	,	,	,
cord-003302-vxk7uqlc	184	4	the	the	DT
cord-003302-vxk7uqlc	184	5	immune	immune	JJ
cord-003302-vxk7uqlc	184	6	responses	response	NNS
cord-003302-vxk7uqlc	184	7	of	of	IN
cord-003302-vxk7uqlc	184	8	weanlings	weanling	NNS
cord-003302-vxk7uqlc	184	9	to	to	IN
cord-003302-vxk7uqlc	184	10	infection	infection	NN
cord-003302-vxk7uqlc	184	11	were	be	VBD
cord-003302-vxk7uqlc	184	12	robust	robust	JJ
cord-003302-vxk7uqlc	184	13	,	,	,
cord-003302-vxk7uqlc	184	14	but	but	CC
cord-003302-vxk7uqlc	184	15	they	-PRON-	PRP
cord-003302-vxk7uqlc	184	16	were	be	VBD
cord-003302-vxk7uqlc	184	17	different	different	JJ
cord-003302-vxk7uqlc	184	18	.	.	.
cord-003302-vxk7uqlc	185	1	Pro	pro	JJ
cord-003302-vxk7uqlc	185	2	-	-	JJ
cord-003302-vxk7uqlc	185	3	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	185	4	cytokine	cytokine	NN
cord-003302-vxk7uqlc	185	5	responses	response	NNS
cord-003302-vxk7uqlc	185	6	in	in	IN
cord-003302-vxk7uqlc	185	7	the	the	DT
cord-003302-vxk7uqlc	185	8	two	two	CD
cord-003302-vxk7uqlc	185	9	groups	group	NNS
cord-003302-vxk7uqlc	185	10	were	be	VBD
cord-003302-vxk7uqlc	185	11	similar	similar	JJ
cord-003302-vxk7uqlc	185	12	,	,	,
cord-003302-vxk7uqlc	185	13	but	but	CC
cord-003302-vxk7uqlc	185	14	regulatory	regulatory	JJ
cord-003302-vxk7uqlc	185	15	response	response	NN
cord-003302-vxk7uqlc	185	16	genes	gene	NNS
cord-003302-vxk7uqlc	185	17	for	for	IN
cord-003302-vxk7uqlc	185	18	IL-10	IL-10	NNP
cord-003302-vxk7uqlc	185	19	and	and	CC
cord-003302-vxk7uqlc	185	20	TGF-1	TGF-1	NNP
cord-003302-vxk7uqlc	185	21	were	be	VBD
cord-003302-vxk7uqlc	185	22	more	more	RBR
cord-003302-vxk7uqlc	185	23	highly	highly	RB
cord-003302-vxk7uqlc	185	24	expressed	express	VBN
cord-003302-vxk7uqlc	185	25	in	in	IN
cord-003302-vxk7uqlc	185	26	weanlings	weanling	NNS
cord-003302-vxk7uqlc	185	27	[	[	-LRB-
cord-003302-vxk7uqlc	185	28	65	65	CD
cord-003302-vxk7uqlc	185	29	]	]	-RRB-
cord-003302-vxk7uqlc	185	30	.	.	.
cord-003302-vxk7uqlc	186	1	Because	because	IN
cord-003302-vxk7uqlc	186	2	influenza	influenza	NN
cord-003302-vxk7uqlc	186	3	in	in	IN
cord-003302-vxk7uqlc	186	4	ferrets	ferret	NNS
cord-003302-vxk7uqlc	186	5	closely	closely	RB
cord-003302-vxk7uqlc	186	6	mimics	mimic	VBZ
cord-003302-vxk7uqlc	186	7	the	the	DT
cord-003302-vxk7uqlc	186	8	disease	disease	NN
cord-003302-vxk7uqlc	186	9	in	in	IN
cord-003302-vxk7uqlc	186	10	humans	human	NNS
cord-003302-vxk7uqlc	186	11	,	,	,
cord-003302-vxk7uqlc	186	12	this	this	DT
cord-003302-vxk7uqlc	186	13	study	study	NN
cord-003302-vxk7uqlc	186	14	suggests	suggest	VBZ
cord-003302-vxk7uqlc	186	15	that	that	IN
cord-003302-vxk7uqlc	186	16	the	the	DT
cord-003302-vxk7uqlc	186	17	milder	mild	JJR
cord-003302-vxk7uqlc	186	18	response	response	NN
cord-003302-vxk7uqlc	186	19	to	to	IN
cord-003302-vxk7uqlc	186	20	influenza	influenza	NN
cord-003302-vxk7uqlc	186	21	in	in	IN
cord-003302-vxk7uqlc	186	22	children	child	NNS
cord-003302-vxk7uqlc	186	23	compared	compare	VBN
cord-003302-vxk7uqlc	186	24	with	with	IN
cord-003302-vxk7uqlc	186	25	adults	adult	NNS
cord-003302-vxk7uqlc	186	26	is	be	VBZ
cord-003302-vxk7uqlc	186	27	due	due	JJ
cord-003302-vxk7uqlc	186	28	to	to	IN
cord-003302-vxk7uqlc	186	29	a	a	DT
cord-003302-vxk7uqlc	186	30	more	more	RBR
cord-003302-vxk7uqlc	186	31	strongly	strongly	RB
cord-003302-vxk7uqlc	186	32	expressed	express	VBN
cord-003302-vxk7uqlc	186	33	regulatory	regulatory	JJ
cord-003302-vxk7uqlc	186	34	response	response	NN
cord-003302-vxk7uqlc	186	35	.	.	.
cord-003302-vxk7uqlc	187	1	Very	very	RB
cord-003302-vxk7uqlc	187	2	few	few	JJ
cord-003302-vxk7uqlc	187	3	studies	study	NNS
cord-003302-vxk7uqlc	187	4	have	have	VBP
cord-003302-vxk7uqlc	187	5	directly	directly	RB
cord-003302-vxk7uqlc	187	6	compared	compare	VBN
cord-003302-vxk7uqlc	187	7	the	the	DT
cord-003302-vxk7uqlc	187	8	cell	cell	NN
cord-003302-vxk7uqlc	187	9	signaling	signal	VBG
cord-003302-vxk7uqlc	187	10	responses	response	NNS
cord-003302-vxk7uqlc	187	11	of	of	IN
cord-003302-vxk7uqlc	187	12	children	child	NNS
cord-003302-vxk7uqlc	187	13	and	and	CC
cord-003302-vxk7uqlc	187	14	adults	adult	NNS
cord-003302-vxk7uqlc	187	15	to	to	TO
cord-003302-vxk7uqlc	187	16	acute	acute	VB
cord-003302-vxk7uqlc	187	17	critical	critical	JJ
cord-003302-vxk7uqlc	187	18	illness	illness	NN
cord-003302-vxk7uqlc	187	19	.	.	.
cord-003302-vxk7uqlc	188	1	Nonetheless	nonetheless	RB
cord-003302-vxk7uqlc	188	2	,	,	,
cord-003302-vxk7uqlc	188	3	in	in	IN
cord-003302-vxk7uqlc	188	4	2004	2004	CD
cord-003302-vxk7uqlc	188	5	,	,	,
cord-003302-vxk7uqlc	188	6	surgeons	surgeon	NNS
cord-003302-vxk7uqlc	188	7	reported	report	VBD
cord-003302-vxk7uqlc	188	8	two	two	CD
cord-003302-vxk7uqlc	188	9	studies	study	NNS
cord-003302-vxk7uqlc	188	10	that	that	WDT
cord-003302-vxk7uqlc	188	11	directly	directly	RB
cord-003302-vxk7uqlc	188	12	compared	compare	VBD
cord-003302-vxk7uqlc	188	13	the	the	DT
cord-003302-vxk7uqlc	188	14	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	188	15	responses	response	NNS
cord-003302-vxk7uqlc	188	16	of	of	IN
cord-003302-vxk7uqlc	188	17	peritoneal	peritoneal	JJ
cord-003302-vxk7uqlc	188	18	macrophages	macrophage	NNS
cord-003302-vxk7uqlc	188	19	harvested	harvest	VBN
cord-003302-vxk7uqlc	188	20	from	from	IN
cord-003302-vxk7uqlc	188	21	the	the	DT
cord-003302-vxk7uqlc	188	22	sterile	sterile	JJ
cord-003302-vxk7uqlc	188	23	abdomens	abdomen	NNS
cord-003302-vxk7uqlc	188	24	of	of	IN
cord-003302-vxk7uqlc	188	25	children	child	NNS
cord-003302-vxk7uqlc	188	26	and	and	CC
cord-003302-vxk7uqlc	188	27	adults	adult	NNS
cord-003302-vxk7uqlc	188	28	[	[	-LRB-
cord-003302-vxk7uqlc	188	29	67	67	CD
cord-003302-vxk7uqlc	188	30	,	,	,
cord-003302-vxk7uqlc	188	31	68	68	CD
cord-003302-vxk7uqlc	188	32	]	]	-RRB-
cord-003302-vxk7uqlc	188	33	.	.	.
cord-003302-vxk7uqlc	189	1	Pro	pro	JJ
cord-003302-vxk7uqlc	189	2	-	-	:
cord-003302-vxk7uqlc	189	3	and	and	CC
cord-003302-vxk7uqlc	189	4	anti	anti	JJ
cord-003302-vxk7uqlc	189	5	-	-	JJ
cord-003302-vxk7uqlc	189	6	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	189	7	responses	response	NNS
cord-003302-vxk7uqlc	189	8	were	be	VBD
cord-003302-vxk7uqlc	189	9	elicited	elicit	VBN
cord-003302-vxk7uqlc	189	10	by	by	IN
cord-003302-vxk7uqlc	189	11	exposing	expose	VBG
cord-003302-vxk7uqlc	189	12	the	the	DT
cord-003302-vxk7uqlc	189	13	macrophages	macrophage	NNS
cord-003302-vxk7uqlc	189	14	ex	ex	NN
cord-003302-vxk7uqlc	189	15	vivo	vivo	NN
cord-003302-vxk7uqlc	189	16	to	to	IN
cord-003302-vxk7uqlc	189	17	endotoxin	endotoxin	NN
cord-003302-vxk7uqlc	189	18	and	and	CC
cord-003302-vxk7uqlc	190	1	IL-1	IL-1	NNP
cord-003302-vxk7uqlc	190	2	.	.	.
cord-003302-vxk7uqlc	191	1	Unlike	unlike	IN
cord-003302-vxk7uqlc	191	2	adults	adult	NNS
cord-003302-vxk7uqlc	191	3	,	,	,
cord-003302-vxk7uqlc	191	4	responses	response	NNS
cord-003302-vxk7uqlc	191	5	in	in	IN
cord-003302-vxk7uqlc	191	6	children	child	NNS
cord-003302-vxk7uqlc	191	7	were	be	VBD
cord-003302-vxk7uqlc	191	8	dominated	dominate	VBN
cord-003302-vxk7uqlc	191	9	by	by	IN
cord-003302-vxk7uqlc	191	10	an	an	DT
cord-003302-vxk7uqlc	191	11	IL-10	IL-10	NNP
cord-003302-vxk7uqlc	191	12	anti	anti	JJ
cord-003302-vxk7uqlc	191	13	-	-	JJ
cord-003302-vxk7uqlc	191	14	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	191	15	pattern	pattern	NN
cord-003302-vxk7uqlc	191	16	.	.	.
cord-003302-vxk7uqlc	192	1	Recent	recent	JJ
cord-003302-vxk7uqlc	192	2	research	research	NN
cord-003302-vxk7uqlc	192	3	has	have	VBZ
cord-003302-vxk7uqlc	192	4	shown	show	VBN
cord-003302-vxk7uqlc	192	5	that	that	IN
cord-003302-vxk7uqlc	192	6	DNA	dna	NN
cord-003302-vxk7uqlc	192	7	methylation	methylation	NN
cord-003302-vxk7uqlc	192	8	stably	stably	RB
cord-003302-vxk7uqlc	192	9	reduces	reduce	VBZ
cord-003302-vxk7uqlc	192	10	the	the	DT
cord-003302-vxk7uqlc	192	11	expression	expression	NN
cord-003302-vxk7uqlc	192	12	of	of	IN
cord-003302-vxk7uqlc	192	13	IL-10	IL-10	NNP
cord-003302-vxk7uqlc	192	14	in	in	IN
cord-003302-vxk7uqlc	192	15	Th1	th1	NN
cord-003302-vxk7uqlc	192	16	cells	cell	NNS
cord-003302-vxk7uqlc	192	17	[	[	-LRB-
cord-003302-vxk7uqlc	192	18	69	69	CD
cord-003302-vxk7uqlc	192	19	]	]	-RRB-
cord-003302-vxk7uqlc	192	20	.	.	.
cord-003302-vxk7uqlc	193	1	Short	short	JJ
cord-003302-vxk7uqlc	193	2	-	-	HYPH
cord-003302-vxk7uqlc	193	3	term	term	NN
cord-003302-vxk7uqlc	193	4	reversal	reversal	NN
cord-003302-vxk7uqlc	193	5	of	of	IN
cord-003302-vxk7uqlc	193	6	this	this	DT
cord-003302-vxk7uqlc	193	7	epigenetic	epigenetic	JJ
cord-003302-vxk7uqlc	193	8	mechanism	mechanism	NN
cord-003302-vxk7uqlc	193	9	can	can	MD
cord-003302-vxk7uqlc	193	10	bring	bring	VB
cord-003302-vxk7uqlc	193	11	about	about	RP
cord-003302-vxk7uqlc	193	12	an	an	DT
cord-003302-vxk7uqlc	193	13	increase	increase	NN
cord-003302-vxk7uqlc	193	14	in	in	IN
cord-003302-vxk7uqlc	193	15	IL-10	IL-10	NNP
cord-003302-vxk7uqlc	193	16	gene	gene	NN
cord-003302-vxk7uqlc	193	17	expression	expression	NN
cord-003302-vxk7uqlc	193	18	.	.	.
cord-003302-vxk7uqlc	194	1	A	a	DT
cord-003302-vxk7uqlc	194	2	decade	decade	NN
cord-003302-vxk7uqlc	194	3	ago	ago	RB
cord-003302-vxk7uqlc	194	4	,	,	,
cord-003302-vxk7uqlc	194	5	surgeons	surgeon	NNS
cord-003302-vxk7uqlc	194	6	who	who	WP
cord-003302-vxk7uqlc	194	7	were	be	VBD
cord-003302-vxk7uqlc	194	8	involved	involve	VBN
cord-003302-vxk7uqlc	194	9	in	in	IN
cord-003302-vxk7uqlc	194	10	liver	liver	NN
cord-003302-vxk7uqlc	194	11	transplantation	transplantation	NN
cord-003302-vxk7uqlc	194	12	in	in	IN
cord-003302-vxk7uqlc	194	13	children	child	NNS
cord-003302-vxk7uqlc	194	14	and	and	CC
cord-003302-vxk7uqlc	194	15	adults	adult	NNS
cord-003302-vxk7uqlc	194	16	sought	seek	VBD
cord-003302-vxk7uqlc	194	17	to	to	TO
cord-003302-vxk7uqlc	194	18	better	better	RB
cord-003302-vxk7uqlc	194	19	understand	understand	VB
cord-003302-vxk7uqlc	194	20	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	194	21	responses	response	NNS
cord-003302-vxk7uqlc	194	22	in	in	IN
cord-003302-vxk7uqlc	194	23	their	-PRON-	PRP$
cord-003302-vxk7uqlc	194	24	patients	patient	NNS
cord-003302-vxk7uqlc	194	25	by	by	IN
cord-003302-vxk7uqlc	194	26	studying	study	VBG
cord-003302-vxk7uqlc	194	27	hepatic	hepatic	JJ
cord-003302-vxk7uqlc	194	28	ischemicreperfusion	ischemicreperfusion	NN
cord-003302-vxk7uqlc	194	29	injury	injury	NN
cord-003302-vxk7uqlc	194	30	in	in	IN
cord-003302-vxk7uqlc	194	31	mice	mouse	NNS
cord-003302-vxk7uqlc	194	32	of	of	IN
cord-003302-vxk7uqlc	194	33	different	different	JJ
cord-003302-vxk7uqlc	194	34	ages	age	NNS
cord-003302-vxk7uqlc	194	35	[	[	-LRB-
cord-003302-vxk7uqlc	194	36	70	70	CD
cord-003302-vxk7uqlc	194	37	]	]	-RRB-
cord-003302-vxk7uqlc	194	38	.	.	.
cord-003302-vxk7uqlc	195	1	They	-PRON-	PRP
cord-003302-vxk7uqlc	195	2	found	find	VBD
cord-003302-vxk7uqlc	195	3	evidence	evidence	NN
cord-003302-vxk7uqlc	195	4	of	of	IN
cord-003302-vxk7uqlc	195	5	less	less	JJR
cord-003302-vxk7uqlc	195	6	inflammation	inflammation	NN
cord-003302-vxk7uqlc	195	7	but	but	CC
cord-003302-vxk7uqlc	195	8	greater	great	JJR
cord-003302-vxk7uqlc	195	9	autophagy	autophagy	NN
cord-003302-vxk7uqlc	195	10	in	in	IN
cord-003302-vxk7uqlc	195	11	the	the	DT
cord-003302-vxk7uqlc	195	12	livers	liver	NNS
cord-003302-vxk7uqlc	195	13	of	of	IN
cord-003302-vxk7uqlc	195	14	younger	young	JJR
cord-003302-vxk7uqlc	195	15	(	(	-LRB-
cord-003302-vxk7uqlc	195	16	4	4	CD
cord-003302-vxk7uqlc	195	17	-	-	HYPH
cord-003302-vxk7uqlc	195	18	5-week	5-week	CD
cord-003302-vxk7uqlc	195	19	old	old	JJ
cord-003302-vxk7uqlc	195	20	)	)	-RRB-
cord-003302-vxk7uqlc	195	21	mice	mouse	NNS
cord-003302-vxk7uqlc	195	22	compared	compare	VBN
cord-003302-vxk7uqlc	195	23	with	with	IN
cord-003302-vxk7uqlc	195	24	older	old	JJR
cord-003302-vxk7uqlc	195	25	(	(	-LRB-
cord-003302-vxk7uqlc	195	26	10	10	CD
cord-003302-vxk7uqlc	195	27	-	-	SYM
cord-003302-vxk7uqlc	195	28	12-week	12-week	JJ
cord-003302-vxk7uqlc	195	29	old	old	JJ
cord-003302-vxk7uqlc	195	30	)	)	-RRB-
cord-003302-vxk7uqlc	195	31	mice	mouse	NNS
cord-003302-vxk7uqlc	195	32	,	,	,
cord-003302-vxk7uqlc	195	33	and	and	CC
cord-003302-vxk7uqlc	195	34	the	the	DT
cord-003302-vxk7uqlc	195	35	response	response	NN
cord-003302-vxk7uqlc	195	36	of	of	IN
cord-003302-vxk7uqlc	195	37	younger	young	JJR
cord-003302-vxk7uqlc	195	38	mice	mouse	NNS
cord-003302-vxk7uqlc	195	39	was	be	VBD
cord-003302-vxk7uqlc	195	40	associated	associate	VBN
cord-003302-vxk7uqlc	195	41	with	with	IN
cord-003302-vxk7uqlc	195	42	greater	great	JJR
cord-003302-vxk7uqlc	195	43	nuclear	nuclear	JJ
cord-003302-vxk7uqlc	195	44	retention	retention	NN
cord-003302-vxk7uqlc	195	45	of	of	IN
cord-003302-vxk7uqlc	195	46	PPARg	PPARg	NNS
cord-003302-vxk7uqlc	195	47	activity	activity	NN
cord-003302-vxk7uqlc	195	48	.	.	.
cord-003302-vxk7uqlc	196	1	Following	follow	VBG
cord-003302-vxk7uqlc	196	2	pretreatment	pretreatment	NN
cord-003302-vxk7uqlc	196	3	(	(	-LRB-
cord-003302-vxk7uqlc	196	4	for	for	IN
cord-003302-vxk7uqlc	196	5	three	three	CD
cord-003302-vxk7uqlc	196	6	days	day	NNS
cord-003302-vxk7uqlc	196	7	)	)	-RRB-
cord-003302-vxk7uqlc	196	8	of	of	IN
cord-003302-vxk7uqlc	196	9	older	old	JJR
cord-003302-vxk7uqlc	196	10	mice	mouse	NNS
cord-003302-vxk7uqlc	196	11	with	with	IN
cord-003302-vxk7uqlc	196	12	the	the	DT
cord-003302-vxk7uqlc	196	13	PPARg	PPARg	NNS
cord-003302-vxk7uqlc	196	14	agonist	agonist	NN
cord-003302-vxk7uqlc	196	15	rosiglitazone	rosiglitazone	NN
cord-003302-vxk7uqlc	196	16	,	,	,
cord-003302-vxk7uqlc	196	17	their	-PRON-	PRP$
cord-003302-vxk7uqlc	196	18	highly	highly	RB
cord-003302-vxk7uqlc	196	19	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	196	20	response	response	NN
cord-003302-vxk7uqlc	196	21	was	be	VBD
cord-003302-vxk7uqlc	196	22	changed	change	VBN
cord-003302-vxk7uqlc	196	23	to	to	IN
cord-003302-vxk7uqlc	196	24	the	the	DT
cord-003302-vxk7uqlc	196	25	less	less	RBR
cord-003302-vxk7uqlc	196	26	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	196	27	response	response	NN
cord-003302-vxk7uqlc	196	28	seen	see	VBN
cord-003302-vxk7uqlc	196	29	in	in	IN
cord-003302-vxk7uqlc	196	30	younger	young	JJR
cord-003302-vxk7uqlc	196	31	mice	mouse	NNS
cord-003302-vxk7uqlc	196	32	,	,	,
cord-003302-vxk7uqlc	196	33	and	and	CC
cord-003302-vxk7uqlc	196	34	this	this	DT
cord-003302-vxk7uqlc	196	35	change	change	NN
cord-003302-vxk7uqlc	196	36	was	be	VBD
cord-003302-vxk7uqlc	196	37	associated	associate	VBN
cord-003302-vxk7uqlc	196	38	with	with	IN
cord-003302-vxk7uqlc	196	39	the	the	DT
cord-003302-vxk7uqlc	196	40	autophagy	autophagy	NN
cord-003302-vxk7uqlc	196	41	pattern	pattern	NN
cord-003302-vxk7uqlc	196	42	seen	see	VBN
cord-003302-vxk7uqlc	196	43	in	in	IN
cord-003302-vxk7uqlc	196	44	younger	young	JJR
cord-003302-vxk7uqlc	196	45	mice	mouse	NNS
cord-003302-vxk7uqlc	196	46	.	.	.
cord-003302-vxk7uqlc	197	1	It	-PRON-	PRP
cord-003302-vxk7uqlc	197	2	is	be	VBZ
cord-003302-vxk7uqlc	197	3	important	important	JJ
cord-003302-vxk7uqlc	197	4	to	to	TO
cord-003302-vxk7uqlc	197	5	recognize	recognize	VB
cord-003302-vxk7uqlc	197	6	that	that	IN
cord-003302-vxk7uqlc	197	7	in	in	IN
cord-003302-vxk7uqlc	197	8	this	this	DT
cord-003302-vxk7uqlc	197	9	study	study	NN
cord-003302-vxk7uqlc	197	10	younger	young	JJR
cord-003302-vxk7uqlc	197	11	mice	mouse	NNS
cord-003302-vxk7uqlc	197	12	were	be	VBD
cord-003302-vxk7uqlc	197	13	not	not	RB
cord-003302-vxk7uqlc	197	14	clearly	clearly	RB
cord-003302-vxk7uqlc	197	15	shown	show	VBN
cord-003302-vxk7uqlc	197	16	to	to	TO
cord-003302-vxk7uqlc	197	17	be	be	VB
cord-003302-vxk7uqlc	197	18	pre	pre	JJ
cord-003302-vxk7uqlc	197	19	-	-	JJ
cord-003302-vxk7uqlc	197	20	pubertal	pubertal	JJ
cord-003302-vxk7uqlc	197	21	and	and	CC
cord-003302-vxk7uqlc	197	22	treatment	treatment	NN
cord-003302-vxk7uqlc	197	23	was	be	VBD
cord-003302-vxk7uqlc	197	24	given	give	VBN
cord-003302-vxk7uqlc	197	25	before	before	RB
cord-003302-vxk7uqlc	197	26	,	,	,
cord-003302-vxk7uqlc	197	27	not	not	RB
cord-003302-vxk7uqlc	197	28	after	after	IN
cord-003302-vxk7uqlc	197	29	the	the	DT
cord-003302-vxk7uqlc	197	30	ischemic	ischemic	JJ
cord-003302-vxk7uqlc	197	31	episode	episode	NN
cord-003302-vxk7uqlc	197	32	.	.	.
cord-003302-vxk7uqlc	198	1	Nonetheless	nonetheless	RB
cord-003302-vxk7uqlc	198	2	,	,	,
cord-003302-vxk7uqlc	198	3	pre	pre	JJ
cord-003302-vxk7uqlc	198	4	-	-	NN
cord-003302-vxk7uqlc	198	5	treatment	treatment	NN
cord-003302-vxk7uqlc	198	6	with	with	IN
cord-003302-vxk7uqlc	198	7	rosiglitazone	rosiglitazone	NN
cord-003302-vxk7uqlc	198	8	was	be	VBD
cord-003302-vxk7uqlc	198	9	able	able	JJ
cord-003302-vxk7uqlc	198	10	to	to	TO
cord-003302-vxk7uqlc	198	11	"	"	``
cord-003302-vxk7uqlc	198	12	roll	roll	VB
cord-003302-vxk7uqlc	198	13	back	back	RP
cord-003302-vxk7uqlc	198	14	"	"	''
cord-003302-vxk7uqlc	198	15	the	the	DT
cord-003302-vxk7uqlc	198	16	damaging	damaging	JJ
cord-003302-vxk7uqlc	198	17	response	response	NN
cord-003302-vxk7uqlc	198	18	of	of	IN
cord-003302-vxk7uqlc	198	19	"	"	``
cord-003302-vxk7uqlc	198	20	adults	adult	NNS
cord-003302-vxk7uqlc	198	21	"	"	''
cord-003302-vxk7uqlc	198	22	to	to	IN
cord-003302-vxk7uqlc	198	23	the	the	DT
cord-003302-vxk7uqlc	198	24	more	more	RBR
cord-003302-vxk7uqlc	198	25	benign	benign	JJ
cord-003302-vxk7uqlc	198	26	response	response	NN
cord-003302-vxk7uqlc	198	27	of	of	IN
cord-003302-vxk7uqlc	198	28	"	"	``
cord-003302-vxk7uqlc	198	29	children	child	NNS
cord-003302-vxk7uqlc	198	30	"	"	''
cord-003302-vxk7uqlc	198	31	.	.	.
cord-003302-vxk7uqlc	199	1	PPARg	PPARg	NNS
cord-003302-vxk7uqlc	199	2	agonists	agonist	NNS
cord-003302-vxk7uqlc	199	3	have	have	VBP
cord-003302-vxk7uqlc	199	4	important	important	JJ
cord-003302-vxk7uqlc	199	5	effects	effect	NNS
cord-003302-vxk7uqlc	199	6	on	on	IN
cord-003302-vxk7uqlc	199	7	energy	energy	NN
cord-003302-vxk7uqlc	199	8	metabolism	metabolism	NN
cord-003302-vxk7uqlc	199	9	,	,	,
cord-003302-vxk7uqlc	199	10	and	and	CC
cord-003302-vxk7uqlc	199	11	there	there	EX
cord-003302-vxk7uqlc	199	12	is	be	VBZ
cord-003302-vxk7uqlc	199	13	considerable	considerable	JJ
cord-003302-vxk7uqlc	199	14	"	"	``
cord-003302-vxk7uqlc	199	15	crosstalk	crosstalk	NN
cord-003302-vxk7uqlc	199	16	"	"	''
cord-003302-vxk7uqlc	199	17	among	among	IN
cord-003302-vxk7uqlc	199	18	these	these	DT
cord-003302-vxk7uqlc	199	19	agents	agent	NNS
cord-003302-vxk7uqlc	199	20	(	(	-LRB-
cord-003302-vxk7uqlc	199	21	glitazones	glitazones	NNP
cord-003302-vxk7uqlc	199	22	)	)	-RRB-
cord-003302-vxk7uqlc	199	23	and	and	CC
cord-003302-vxk7uqlc	199	24	other	other	JJ
cord-003302-vxk7uqlc	199	25	drugs	drug	NNS
cord-003302-vxk7uqlc	199	26	that	that	WDT
cord-003302-vxk7uqlc	199	27	also	also	RB
cord-003302-vxk7uqlc	199	28	have	have	VBP
cord-003302-vxk7uqlc	199	29	immunometabolic	immunometabolic	JJ
cord-003302-vxk7uqlc	199	30	activities	activity	NNS
cord-003302-vxk7uqlc	199	31	(	(	-LRB-
cord-003302-vxk7uqlc	199	32	e.g.	e.g.	RB
cord-003302-vxk7uqlc	199	33	,	,	,
cord-003302-vxk7uqlc	199	34	statins	statin	NNS
cord-003302-vxk7uqlc	199	35	[	[	-LRB-
cord-003302-vxk7uqlc	199	36	71	71	CD
cord-003302-vxk7uqlc	199	37	]	]	-RRB-
cord-003302-vxk7uqlc	199	38	,	,	,
cord-003302-vxk7uqlc	199	39	ACE	ACE	NNP
cord-003302-vxk7uqlc	199	40	inhibitors	inhibitor	NNS
cord-003302-vxk7uqlc	199	41	and	and	CC
cord-003302-vxk7uqlc	199	42	angiotensin	angiotensin	NN
cord-003302-vxk7uqlc	199	43	receptor	receptor	NN
cord-003302-vxk7uqlc	199	44	blockers	blocker	NNS
cord-003302-vxk7uqlc	199	45	[	[	-LRB-
cord-003302-vxk7uqlc	199	46	72	72	CD
cord-003302-vxk7uqlc	199	47	]	]	-RRB-
cord-003302-vxk7uqlc	199	48	,	,	,
cord-003302-vxk7uqlc	199	49	metformin	metformin	NNP
cord-003302-vxk7uqlc	199	50	[	[	-LRB-
cord-003302-vxk7uqlc	199	51	73	73	CD
cord-003302-vxk7uqlc	199	52	]	]	-RRB-
cord-003302-vxk7uqlc	199	53	)	)	-RRB-
cord-003302-vxk7uqlc	200	1	[	[	-LRB-
cord-003302-vxk7uqlc	200	2	5	5	CD
cord-003302-vxk7uqlc	200	3	]	]	-RRB-
cord-003302-vxk7uqlc	200	4	[	[	-LRB-
cord-003302-vxk7uqlc	200	5	6	6	CD
cord-003302-vxk7uqlc	200	6	]	]	-RRB-
cord-003302-vxk7uqlc	200	7	[	[	-LRB-
cord-003302-vxk7uqlc	200	8	7	7	CD
cord-003302-vxk7uqlc	200	9	]	]	-RRB-
cord-003302-vxk7uqlc	201	1	[	[	-LRB-
cord-003302-vxk7uqlc	201	2	8	8	CD
cord-003302-vxk7uqlc	201	3	]	]	-RRB-
cord-003302-vxk7uqlc	201	4	[	[	-LRB-
cord-003302-vxk7uqlc	201	5	9	9	CD
cord-003302-vxk7uqlc	201	6	]	]	-RRB-
cord-003302-vxk7uqlc	201	7	.	.	.
cord-003302-vxk7uqlc	202	1	These	these	DT
cord-003302-vxk7uqlc	202	2	findings	finding	NNS
cord-003302-vxk7uqlc	202	3	suggest	suggest	VBP
cord-003302-vxk7uqlc	202	4	that	that	IN
cord-003302-vxk7uqlc	202	5	many	many	JJ
cord-003302-vxk7uqlc	202	6	if	if	IN
cord-003302-vxk7uqlc	202	7	not	not	RB
cord-003302-vxk7uqlc	202	8	all	all	DT
cord-003302-vxk7uqlc	202	9	of	of	IN
cord-003302-vxk7uqlc	202	10	these	these	DT
cord-003302-vxk7uqlc	202	11	drugs	drug	NNS
cord-003302-vxk7uqlc	202	12	could	could	MD
cord-003302-vxk7uqlc	202	13	be	be	VB
cord-003302-vxk7uqlc	202	14	used	use	VBN
cord-003302-vxk7uqlc	202	15	to	to	TO
cord-003302-vxk7uqlc	202	16	change	change	VB
cord-003302-vxk7uqlc	202	17	the	the	DT
cord-003302-vxk7uqlc	202	18	host	host	NN
cord-003302-vxk7uqlc	202	19	response	response	NN
cord-003302-vxk7uqlc	202	20	of	of	IN
cord-003302-vxk7uqlc	202	21	adults	adult	NNS
cord-003302-vxk7uqlc	202	22	to	to	IN
cord-003302-vxk7uqlc	202	23	that	that	DT
cord-003302-vxk7uqlc	202	24	seen	see	VBN
cord-003302-vxk7uqlc	202	25	in	in	IN
cord-003302-vxk7uqlc	202	26	children	child	NNS
cord-003302-vxk7uqlc	202	27	.	.	.
cord-003302-vxk7uqlc	203	1	The	the	DT
cord-003302-vxk7uqlc	203	2	drugs	drug	NNS
cord-003302-vxk7uqlc	203	3	would	would	MD
cord-003302-vxk7uqlc	203	4	probably	probably	RB
cord-003302-vxk7uqlc	203	5	work	work	VB
cord-003302-vxk7uqlc	203	6	better	well	RBR
cord-003302-vxk7uqlc	203	7	if	if	IN
cord-003302-vxk7uqlc	203	8	given	give	VBN
cord-003302-vxk7uqlc	203	9	in	in	IN
cord-003302-vxk7uqlc	203	10	combination	combination	NN
cord-003302-vxk7uqlc	203	11	rather	rather	RB
cord-003302-vxk7uqlc	203	12	than	than	IN
cord-003302-vxk7uqlc	203	13	by	by	IN
cord-003302-vxk7uqlc	203	14	themselves	-PRON-	PRP
cord-003302-vxk7uqlc	203	15	[	[	-LRB-
cord-003302-vxk7uqlc	203	16	8	8	CD
cord-003302-vxk7uqlc	203	17	]	]	-RRB-
cord-003302-vxk7uqlc	203	18	.	.	.
cord-003302-vxk7uqlc	204	1	For	for	IN
cord-003302-vxk7uqlc	204	2	a	a	DT
cord-003302-vxk7uqlc	204	3	severe	severe	JJ
cord-003302-vxk7uqlc	204	4	infection	infection	NN
cord-003302-vxk7uqlc	204	5	like	like	IN
cord-003302-vxk7uqlc	204	6	pandemic	pandemic	NN
cord-003302-vxk7uqlc	204	7	influenza	influenza	NN
cord-003302-vxk7uqlc	204	8	,	,	,
cord-003302-vxk7uqlc	204	9	treatment	treatment	NN
cord-003302-vxk7uqlc	204	10	with	with	IN
cord-003302-vxk7uqlc	204	11	these	these	DT
cord-003302-vxk7uqlc	204	12	drugs	drug	NNS
cord-003302-vxk7uqlc	204	13	could	could	MD
cord-003302-vxk7uqlc	204	14	improve	improve	VB
cord-003302-vxk7uqlc	204	15	an	an	DT
cord-003302-vxk7uqlc	204	16	adult	adult	NN
cord-003302-vxk7uqlc	204	17	's	's	POS
cord-003302-vxk7uqlc	204	18	tolerance	tolerance	NN
cord-003302-vxk7uqlc	204	19	of	of	IN
cord-003302-vxk7uqlc	204	20	infection	infection	NN
cord-003302-vxk7uqlc	204	21	[	[	-LRB-
cord-003302-vxk7uqlc	204	22	44	44	CD
cord-003302-vxk7uqlc	204	23	]	]	-RRB-
cord-003302-vxk7uqlc	204	24	[	[	-LRB-
cord-003302-vxk7uqlc	204	25	45	45	CD
cord-003302-vxk7uqlc	204	26	]	]	-RRB-
cord-003302-vxk7uqlc	204	27	[	[	-LRB-
cord-003302-vxk7uqlc	204	28	46	46	CD
cord-003302-vxk7uqlc	204	29	]	]	-RRB-
cord-003302-vxk7uqlc	204	30	[	[	-LRB-
cord-003302-vxk7uqlc	204	31	47	47	CD
cord-003302-vxk7uqlc	204	32	]	]	-RRB-
cord-003302-vxk7uqlc	204	33	and	and	CC
cord-003302-vxk7uqlc	204	34	might	may	MD
cord-003302-vxk7uqlc	204	35	improve	improve	VB
cord-003302-vxk7uqlc	204	36	survival	survival	NN
cord-003302-vxk7uqlc	204	37	.	.	.
cord-003302-vxk7uqlc	205	1	The	the	DT
cord-003302-vxk7uqlc	205	2	drugs	drug	NNS
cord-003302-vxk7uqlc	205	3	might	may	MD
cord-003302-vxk7uqlc	205	4	also	also	RB
cord-003302-vxk7uqlc	205	5	have	have	VB
cord-003302-vxk7uqlc	205	6	similar	similar	JJ
cord-003302-vxk7uqlc	205	7	effects	effect	NNS
cord-003302-vxk7uqlc	205	8	in	in	IN
cord-003302-vxk7uqlc	205	9	children	child	NNS
cord-003302-vxk7uqlc	205	10	who	who	WP
cord-003302-vxk7uqlc	205	11	develop	develop	VBP
cord-003302-vxk7uqlc	205	12	life	life	NN
cord-003302-vxk7uqlc	205	13	-	-	HYPH
cord-003302-vxk7uqlc	205	14	threatening	threaten	VBG
cord-003302-vxk7uqlc	205	15	illness	illness	NN
cord-003302-vxk7uqlc	205	16	.	.	.
cord-003302-vxk7uqlc	206	1	Ever	ever	RB
cord-003302-vxk7uqlc	206	2	since	since	IN
cord-003302-vxk7uqlc	206	3	the	the	DT
cord-003302-vxk7uqlc	206	4	emergence	emergence	NN
cord-003302-vxk7uqlc	206	5	of	of	IN
cord-003302-vxk7uqlc	206	6	highly	highly	RB
cord-003302-vxk7uqlc	206	7	virulent	virulent	JJ
cord-003302-vxk7uqlc	206	8	avian	avian	JJ
cord-003302-vxk7uqlc	206	9	H5N1	H5N1	NNP
cord-003302-vxk7uqlc	206	10	influenza	influenza	NN
cord-003302-vxk7uqlc	206	11	in	in	IN
cord-003302-vxk7uqlc	206	12	1997	1997	CD
cord-003302-vxk7uqlc	206	13	,	,	,
cord-003302-vxk7uqlc	206	14	virologists	virologist	NNS
cord-003302-vxk7uqlc	206	15	have	have	VBP
cord-003302-vxk7uqlc	206	16	warned	warn	VBN
cord-003302-vxk7uqlc	206	17	of	of	IN
cord-003302-vxk7uqlc	206	18	the	the	DT
cord-003302-vxk7uqlc	206	19	possibility	possibility	NN
cord-003302-vxk7uqlc	206	20	of	of	IN
cord-003302-vxk7uqlc	206	21	a	a	DT
cord-003302-vxk7uqlc	206	22	new	new	JJ
cord-003302-vxk7uqlc	206	23	and	and	CC
cord-003302-vxk7uqlc	206	24	devastating	devastating	JJ
cord-003302-vxk7uqlc	206	25	influenza	influenza	NN
cord-003302-vxk7uqlc	206	26	pandemic	pandemic	NN
cord-003302-vxk7uqlc	206	27	.	.	.
cord-003302-vxk7uqlc	207	1	In	in	IN
cord-003302-vxk7uqlc	207	2	2006	2006	CD
cord-003302-vxk7uqlc	207	3	,	,	,
cord-003302-vxk7uqlc	207	4	epidemiologists	epidemiologist	NNS
cord-003302-vxk7uqlc	207	5	provided	provide	VBD
cord-003302-vxk7uqlc	207	6	an	an	DT
cord-003302-vxk7uqlc	207	7	estimate	estimate	NN
cord-003302-vxk7uqlc	207	8	of	of	IN
cord-003302-vxk7uqlc	207	9	what	what	WP
cord-003302-vxk7uqlc	207	10	global	global	JJ
cord-003302-vxk7uqlc	207	11	mortality	mortality	NN
cord-003302-vxk7uqlc	207	12	might	may	MD
cord-003302-vxk7uqlc	207	13	be	be	VB
cord-003302-vxk7uqlc	207	14	if	if	IN
cord-003302-vxk7uqlc	207	15	the	the	DT
cord-003302-vxk7uqlc	207	16	next	next	JJ
cord-003302-vxk7uqlc	207	17	pandemic	pandemic	NN
cord-003302-vxk7uqlc	207	18	is	be	VBZ
cord-003302-vxk7uqlc	207	19	like	like	IN
cord-003302-vxk7uqlc	207	20	the	the	DT
cord-003302-vxk7uqlc	207	21	one	one	CD
cord-003302-vxk7uqlc	207	22	in	in	IN
cord-003302-vxk7uqlc	207	23	1918	1918	CD
cord-003302-vxk7uqlc	207	24	[	[	-LRB-
cord-003302-vxk7uqlc	207	25	74	74	CD
cord-003302-vxk7uqlc	207	26	]	]	-RRB-
cord-003302-vxk7uqlc	207	27	.	.	.
cord-003302-vxk7uqlc	208	1	This	this	DT
cord-003302-vxk7uqlc	208	2	estimate	estimate	NN
cord-003302-vxk7uqlc	208	3	(	(	-LRB-
cord-003302-vxk7uqlc	208	4	51	51	CD
cord-003302-vxk7uqlc	208	5	to	to	TO
cord-003302-vxk7uqlc	208	6	81	81	CD
cord-003302-vxk7uqlc	208	7	million	million	CD
cord-003302-vxk7uqlc	208	8	deaths	death	NNS
cord-003302-vxk7uqlc	208	9	)	)	-RRB-
cord-003302-vxk7uqlc	208	10	seems	seem	VBZ
cord-003302-vxk7uqlc	208	11	low	low	JJ
cord-003302-vxk7uqlc	208	12	because	because	IN
cord-003302-vxk7uqlc	208	13	in	in	IN
cord-003302-vxk7uqlc	208	14	1918	1918	CD
cord-003302-vxk7uqlc	208	15	pandemic	pandemic	NN
cord-003302-vxk7uqlc	208	16	mortality	mortality	NN
cord-003302-vxk7uqlc	208	17	is	be	VBZ
cord-003302-vxk7uqlc	208	18	thought	think	VBN
cord-003302-vxk7uqlc	208	19	to	to	TO
cord-003302-vxk7uqlc	208	20	have	have	VB
cord-003302-vxk7uqlc	208	21	been	be	VBN
cord-003302-vxk7uqlc	208	22	50	50	CD
cord-003302-vxk7uqlc	208	23	-	-	SYM
cord-003302-vxk7uqlc	208	24	100	100	CD
cord-003302-vxk7uqlc	208	25	million	million	CD
cord-003302-vxk7uqlc	208	26	and	and	CC
cord-003302-vxk7uqlc	208	27	today	today	NN
cord-003302-vxk7uqlc	208	28	the	the	DT
cord-003302-vxk7uqlc	208	29	global	global	JJ
cord-003302-vxk7uqlc	208	30	population	population	NN
cord-003302-vxk7uqlc	208	31	is	be	VBZ
cord-003302-vxk7uqlc	208	32	four	four	CD
cord-003302-vxk7uqlc	208	33	times	time	NNS
cord-003302-vxk7uqlc	208	34	larger	large	JJR
cord-003302-vxk7uqlc	208	35	.	.	.
cord-003302-vxk7uqlc	209	1	A	a	DT
cord-003302-vxk7uqlc	209	2	recent	recent	JJ
cord-003302-vxk7uqlc	209	3	study	study	NN
cord-003302-vxk7uqlc	209	4	from	from	IN
cord-003302-vxk7uqlc	209	5	the	the	DT
cord-003302-vxk7uqlc	209	6	Institute	Institute	NNP
cord-003302-vxk7uqlc	209	7	for	for	IN
cord-003302-vxk7uqlc	209	8	Disease	Disease	NNP
cord-003302-vxk7uqlc	209	9	Modeling	Modeling	NNP
cord-003302-vxk7uqlc	209	10	estimates	estimate	VBZ
cord-003302-vxk7uqlc	209	11	that	that	IN
cord-003302-vxk7uqlc	209	12	during	during	IN
cord-003302-vxk7uqlc	209	13	the	the	DT
cord-003302-vxk7uqlc	209	14	first	first	JJ
cord-003302-vxk7uqlc	209	15	six	six	CD
cord-003302-vxk7uqlc	209	16	months	month	NNS
cord-003302-vxk7uqlc	209	17	of	of	IN
cord-003302-vxk7uqlc	209	18	a	a	DT
cord-003302-vxk7uqlc	209	19	1918-like	1918-like	CD
cord-003302-vxk7uqlc	209	20	pandemic	pandemic	NN
cord-003302-vxk7uqlc	209	21	,	,	,
cord-003302-vxk7uqlc	209	22	almost	almost	RB
cord-003302-vxk7uqlc	209	23	33	33	CD
cord-003302-vxk7uqlc	209	24	million	million	CD
cord-003302-vxk7uqlc	209	25	people	people	NNS
cord-003302-vxk7uqlc	209	26	could	could	MD
cord-003302-vxk7uqlc	209	27	die	die	VB
cord-003302-vxk7uqlc	209	28	[	[	-LRB-
cord-003302-vxk7uqlc	209	29	75	75	CD
cord-003302-vxk7uqlc	209	30	]	]	-RRB-
cord-003302-vxk7uqlc	209	31	.	.	.
cord-003302-vxk7uqlc	210	1	Moreover	moreover	RB
cord-003302-vxk7uqlc	210	2	,	,	,
cord-003302-vxk7uqlc	210	3	if	if	IN
cord-003302-vxk7uqlc	210	4	the	the	DT
cord-003302-vxk7uqlc	210	5	next	next	JJ
cord-003302-vxk7uqlc	210	6	pandemic	pandemic	NN
cord-003302-vxk7uqlc	210	7	is	be	VBZ
cord-003302-vxk7uqlc	210	8	caused	cause	VBN
cord-003302-vxk7uqlc	210	9	by	by	IN
cord-003302-vxk7uqlc	210	10	an	an	DT
cord-003302-vxk7uqlc	210	11	H5N1-like	h5n1-like	JJ
cord-003302-vxk7uqlc	210	12	virus	virus	NN
cord-003302-vxk7uqlc	210	13	,	,	,
cord-003302-vxk7uqlc	210	14	which	which	WDT
cord-003302-vxk7uqlc	210	15	has	have	VBZ
cord-003302-vxk7uqlc	210	16	a	a	DT
cord-003302-vxk7uqlc	210	17	high	high	JJ
cord-003302-vxk7uqlc	210	18	case	case	NN
cord-003302-vxk7uqlc	210	19	fatality	fatality	NN
cord-003302-vxk7uqlc	210	20	rate	rate	NN
cord-003302-vxk7uqlc	210	21	,	,	,
cord-003302-vxk7uqlc	210	22	its	-PRON-	PRP$
cord-003302-vxk7uqlc	210	23	impact	impact	NN
cord-003302-vxk7uqlc	210	24	on	on	IN
cord-003302-vxk7uqlc	210	25	global	global	JJ
cord-003302-vxk7uqlc	210	26	mortality	mortality	NN
cord-003302-vxk7uqlc	210	27	could	could	MD
cord-003302-vxk7uqlc	210	28	be	be	VB
cord-003302-vxk7uqlc	210	29	much	much	RB
cord-003302-vxk7uqlc	210	30	worse	bad	JJR
cord-003302-vxk7uqlc	210	31	[	[	-LRB-
cord-003302-vxk7uqlc	210	32	3	3	CD
cord-003302-vxk7uqlc	210	33	]	]	-RRB-
cord-003302-vxk7uqlc	210	34	[	[	-LRB-
cord-003302-vxk7uqlc	210	35	4	4	CD
cord-003302-vxk7uqlc	210	36	]	]	-RRB-
cord-003302-vxk7uqlc	210	37	[	[	-LRB-
cord-003302-vxk7uqlc	210	38	5	5	CD
cord-003302-vxk7uqlc	210	39	]	]	-RRB-
cord-003302-vxk7uqlc	210	40	[	[	-LRB-
cord-003302-vxk7uqlc	210	41	6	6	CD
cord-003302-vxk7uqlc	210	42	]	]	-RRB-
cord-003302-vxk7uqlc	210	43	.	.	.
cord-003302-vxk7uqlc	211	1	Influenza	influenza	NN
cord-003302-vxk7uqlc	211	2	virologists	virologist	NNS
cord-003302-vxk7uqlc	211	3	are	be	VBP
cord-003302-vxk7uqlc	211	4	now	now	RB
cord-003302-vxk7uqlc	211	5	concerned	concerned	JJ
cord-003302-vxk7uqlc	211	6	about	about	IN
cord-003302-vxk7uqlc	211	7	the	the	DT
cord-003302-vxk7uqlc	211	8	possibility	possibility	NN
cord-003302-vxk7uqlc	211	9	of	of	IN
cord-003302-vxk7uqlc	211	10	an	an	DT
cord-003302-vxk7uqlc	211	11	H7N9	H7N9	NNP
cord-003302-vxk7uqlc	211	12	pandemic	pandemic	NN
cord-003302-vxk7uqlc	211	13	[	[	-LRB-
cord-003302-vxk7uqlc	211	14	9	9	CD
cord-003302-vxk7uqlc	211	15	,	,	,
cord-003302-vxk7uqlc	211	16	76	76	CD
cord-003302-vxk7uqlc	211	17	]	]	-RRB-
cord-003302-vxk7uqlc	211	18	.	.	.
cord-003302-vxk7uqlc	212	1	Nonetheless	nonetheless	RB
cord-003302-vxk7uqlc	212	2	,	,	,
cord-003302-vxk7uqlc	212	3	even	even	RB
cord-003302-vxk7uqlc	212	4	in	in	IN
cord-003302-vxk7uqlc	212	5	the	the	DT
cord-003302-vxk7uqlc	212	6	absence	absence	NN
cord-003302-vxk7uqlc	212	7	of	of	IN
cord-003302-vxk7uqlc	212	8	pandemics	pandemic	NNS
cord-003302-vxk7uqlc	212	9	,	,	,
cord-003302-vxk7uqlc	212	10	yearly	yearly	JJ
cord-003302-vxk7uqlc	212	11	outbreaks	outbreak	NNS
cord-003302-vxk7uqlc	212	12	of	of	IN
cord-003302-vxk7uqlc	212	13	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	212	14	influenza	influenza	NN
cord-003302-vxk7uqlc	212	15	cause	cause	VB
cord-003302-vxk7uqlc	212	16	appreciable	appreciable	JJ
cord-003302-vxk7uqlc	212	17	mortality	mortality	NN
cord-003302-vxk7uqlc	212	18	worldwide	worldwide	RB
cord-003302-vxk7uqlc	212	19	[	[	-LRB-
cord-003302-vxk7uqlc	212	20	77	77	CD
cord-003302-vxk7uqlc	212	21	]	]	-RRB-
cord-003302-vxk7uqlc	212	22	.	.	.
cord-003302-vxk7uqlc	213	1	Most	Most	JJS
cord-003302-vxk7uqlc	213	2	of	of	IN
cord-003302-vxk7uqlc	213	3	these	these	DT
cord-003302-vxk7uqlc	213	4	influenza	influenza	NN
cord-003302-vxk7uqlc	213	5	-	-	HYPH
cord-003302-vxk7uqlc	213	6	related	relate	VBN
cord-003302-vxk7uqlc	213	7	deaths	death	NNS
cord-003302-vxk7uqlc	213	8	(	(	-LRB-
cord-003302-vxk7uqlc	213	9	pandemic	pandemic	NN
cord-003302-vxk7uqlc	213	10	and	and	CC
cord-003302-vxk7uqlc	213	11	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	213	12	)	)	-RRB-
cord-003302-vxk7uqlc	213	13	occur	occur	VBP
cord-003302-vxk7uqlc	213	14	in	in	IN
cord-003302-vxk7uqlc	213	15	developing	develop	VBG
cord-003302-vxk7uqlc	213	16	countries	country	NNS
cord-003302-vxk7uqlc	213	17	[	[	-LRB-
cord-003302-vxk7uqlc	213	18	74	74	CD
cord-003302-vxk7uqlc	213	19	,	,	,
cord-003302-vxk7uqlc	213	20	77	77	CD
cord-003302-vxk7uqlc	213	21	]	]	-RRB-
cord-003302-vxk7uqlc	213	22	.	.	.
cord-003302-vxk7uqlc	214	1	Current	current	JJ
cord-003302-vxk7uqlc	214	2	strategies	strategy	NNS
cord-003302-vxk7uqlc	214	3	for	for	IN
cord-003302-vxk7uqlc	214	4	national	national	JJ
cord-003302-vxk7uqlc	214	5	and	and	CC
cord-003302-vxk7uqlc	214	6	global	global	JJ
cord-003302-vxk7uqlc	214	7	pandemic	pandemic	NN
cord-003302-vxk7uqlc	214	8	preparedness	preparedness	NN
cord-003302-vxk7uqlc	214	9	focus	focus	NN
cord-003302-vxk7uqlc	214	10	on	on	IN
cord-003302-vxk7uqlc	214	11	influenza	influenza	JJ
cord-003302-vxk7uqlc	214	12	vaccination	vaccination	NN
cord-003302-vxk7uqlc	214	13	for	for	IN
cord-003302-vxk7uqlc	214	14	populations	population	NNS
cord-003302-vxk7uqlc	214	15	and	and	CC
cord-003302-vxk7uqlc	214	16	antiviral	antiviral	JJ
cord-003302-vxk7uqlc	214	17	treatment	treatment	NN
cord-003302-vxk7uqlc	214	18	for	for	IN
cord-003302-vxk7uqlc	214	19	individuals	individual	NNS
cord-003302-vxk7uqlc	214	20	[	[	-LRB-
cord-003302-vxk7uqlc	214	21	9	9	CD
cord-003302-vxk7uqlc	214	22	]	]	-RRB-
cord-003302-vxk7uqlc	214	23	.	.	.
cord-003302-vxk7uqlc	215	1	Influenza	influenza	NN
cord-003302-vxk7uqlc	215	2	virologists	virologist	NNS
cord-003302-vxk7uqlc	215	3	hope	hope	VBP
cord-003302-vxk7uqlc	215	4	to	to	TO
cord-003302-vxk7uqlc	215	5	develop	develop	VB
cord-003302-vxk7uqlc	215	6	universal	universal	JJ
cord-003302-vxk7uqlc	215	7	influenza	influenza	NN
cord-003302-vxk7uqlc	215	8	vaccines	vaccine	NNS
cord-003302-vxk7uqlc	215	9	that	that	WDT
cord-003302-vxk7uqlc	215	10	will	will	MD
cord-003302-vxk7uqlc	215	11	provide	provide	VB
cord-003302-vxk7uqlc	215	12	long	long	RB
cord-003302-vxk7uqlc	215	13	-	-	HYPH
cord-003302-vxk7uqlc	215	14	lasting	last	VBG
cord-003302-vxk7uqlc	215	15	protection	protection	NN
cord-003302-vxk7uqlc	215	16	,	,	,
cord-003302-vxk7uqlc	215	17	making	make	VBG
cord-003302-vxk7uqlc	215	18	it	-PRON-	PRP
cord-003302-vxk7uqlc	215	19	unnecessary	unnecessary	JJ
cord-003302-vxk7uqlc	215	20	to	to	TO
cord-003302-vxk7uqlc	215	21	vaccinate	vaccinate	VB
cord-003302-vxk7uqlc	215	22	against	against	IN
cord-003302-vxk7uqlc	215	23	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	215	24	influenza	influenza	NN
cord-003302-vxk7uqlc	215	25	each	each	DT
cord-003302-vxk7uqlc	215	26	year	year	NN
cord-003302-vxk7uqlc	215	27	[	[	-LRB-
cord-003302-vxk7uqlc	215	28	78	78	CD
cord-003302-vxk7uqlc	215	29	]	]	-RRB-
cord-003302-vxk7uqlc	215	30	.	.	.
cord-003302-vxk7uqlc	216	1	Vaccination	vaccination	NN
cord-003302-vxk7uqlc	216	2	with	with	IN
cord-003302-vxk7uqlc	216	3	a	a	DT
cord-003302-vxk7uqlc	216	4	universal	universal	JJ
cord-003302-vxk7uqlc	216	5	vaccine	vaccine	NN
cord-003302-vxk7uqlc	216	6	might	may	MD
cord-003302-vxk7uqlc	216	7	conceivably	conceivably	RB
cord-003302-vxk7uqlc	216	8	provide	provide	VB
cord-003302-vxk7uqlc	216	9	protection	protection	NN
cord-003302-vxk7uqlc	216	10	against	against	IN
cord-003302-vxk7uqlc	216	11	infection	infection	NN
cord-003302-vxk7uqlc	216	12	with	with	IN
cord-003302-vxk7uqlc	216	13	a	a	DT
cord-003302-vxk7uqlc	216	14	future	future	JJ
cord-003302-vxk7uqlc	216	15	pandemic	pandemic	NN
cord-003302-vxk7uqlc	216	16	virus	virus	NN
cord-003302-vxk7uqlc	216	17	.	.	.
cord-003302-vxk7uqlc	217	1	Recent	recent	JJ
cord-003302-vxk7uqlc	217	2	virologic	virologic	JJ
cord-003302-vxk7uqlc	217	3	studies	study	NNS
cord-003302-vxk7uqlc	217	4	,	,	,
cord-003302-vxk7uqlc	217	5	however	however	RB
cord-003302-vxk7uqlc	217	6	,	,	,
cord-003302-vxk7uqlc	217	7	raise	raise	VB
cord-003302-vxk7uqlc	217	8	important	important	JJ
cord-003302-vxk7uqlc	217	9	questions	question	NNS
cord-003302-vxk7uqlc	217	10	about	about	IN
cord-003302-vxk7uqlc	217	11	whether	whether	IN
cord-003302-vxk7uqlc	217	12	this	this	DT
cord-003302-vxk7uqlc	217	13	strategy	strategy	NN
cord-003302-vxk7uqlc	217	14	will	will	MD
cord-003302-vxk7uqlc	217	15	work	work	VB
cord-003302-vxk7uqlc	217	16	[	[	-LRB-
cord-003302-vxk7uqlc	217	17	79	79	CD
cord-003302-vxk7uqlc	217	18	,	,	,
cord-003302-vxk7uqlc	217	19	80	80	CD
cord-003302-vxk7uqlc	217	20	]	]	-RRB-
cord-003302-vxk7uqlc	217	21	.	.	.
cord-003302-vxk7uqlc	218	1	Moreover	moreover	RB
cord-003302-vxk7uqlc	218	2	,	,	,
cord-003302-vxk7uqlc	218	3	much	much	JJ
cord-003302-vxk7uqlc	218	4	of	of	IN
cord-003302-vxk7uqlc	218	5	the	the	DT
cord-003302-vxk7uqlc	218	6	world	world	NN
cord-003302-vxk7uqlc	218	7	will	will	MD
cord-003302-vxk7uqlc	218	8	lack	lack	VB
cord-003302-vxk7uqlc	218	9	the	the	DT
cord-003302-vxk7uqlc	218	10	human	human	JJ
cord-003302-vxk7uqlc	218	11	infrastructure	infrastructure	NN
cord-003302-vxk7uqlc	218	12	to	to	TO
cord-003302-vxk7uqlc	218	13	guarantee	guarantee	VB
cord-003302-vxk7uqlc	218	14	administration	administration	NN
cord-003302-vxk7uqlc	218	15	of	of	IN
cord-003302-vxk7uqlc	218	16	a	a	DT
cord-003302-vxk7uqlc	218	17	universal	universal	JJ
cord-003302-vxk7uqlc	218	18	vaccine	vaccine	NN
cord-003302-vxk7uqlc	218	19	[	[	-LRB-
cord-003302-vxk7uqlc	218	20	9	9	CD
cord-003302-vxk7uqlc	218	21	]	]	-RRB-
cord-003302-vxk7uqlc	218	22	.	.	.
cord-003302-vxk7uqlc	219	1	This	this	DT
cord-003302-vxk7uqlc	219	2	means	mean	VBZ
cord-003302-vxk7uqlc	219	3	that	that	IN
cord-003302-vxk7uqlc	219	4	for	for	IN
cord-003302-vxk7uqlc	219	5	the	the	DT
cord-003302-vxk7uqlc	219	6	foreseeable	foreseeable	JJ
cord-003302-vxk7uqlc	219	7	future	future	NN
cord-003302-vxk7uqlc	219	8	,	,	,
cord-003302-vxk7uqlc	219	9	health	health	NN
cord-003302-vxk7uqlc	219	10	officials	official	NNS
cord-003302-vxk7uqlc	219	11	responsible	responsible	JJ
cord-003302-vxk7uqlc	219	12	for	for	IN
cord-003302-vxk7uqlc	219	13	pandemic	pandemic	JJ
cord-003302-vxk7uqlc	219	14	preparedness	preparedness	NN
cord-003302-vxk7uqlc	219	15	will	will	MD
cord-003302-vxk7uqlc	219	16	have	have	VB
cord-003302-vxk7uqlc	219	17	to	to	TO
cord-003302-vxk7uqlc	219	18	count	count	VB
cord-003302-vxk7uqlc	219	19	on	on	IN
cord-003302-vxk7uqlc	219	20	using	use	VBG
cord-003302-vxk7uqlc	219	21	conventional	conventional	JJ
cord-003302-vxk7uqlc	219	22	pandemic	pandemic	NN
cord-003302-vxk7uqlc	219	23	vaccines	vaccine	NNS
cord-003302-vxk7uqlc	219	24	.	.	.
cord-003302-vxk7uqlc	220	1	Unfortunately	unfortunately	RB
cord-003302-vxk7uqlc	220	2	,	,	,
cord-003302-vxk7uqlc	220	3	none	none	NN
cord-003302-vxk7uqlc	220	4	of	of	IN
cord-003302-vxk7uqlc	220	5	these	these	DT
cord-003302-vxk7uqlc	220	6	vaccines	vaccine	NNS
cord-003302-vxk7uqlc	220	7	will	will	MD
cord-003302-vxk7uqlc	220	8	be	be	VB
cord-003302-vxk7uqlc	220	9	available	available	JJ
cord-003302-vxk7uqlc	220	10	during	during	IN
cord-003302-vxk7uqlc	220	11	the	the	DT
cord-003302-vxk7uqlc	220	12	first	first	JJ
cord-003302-vxk7uqlc	220	13	six	six	CD
cord-003302-vxk7uqlc	220	14	pandemic	pandemic	NN
cord-003302-vxk7uqlc	220	15	months	month	NNS
cord-003302-vxk7uqlc	220	16	[	[	-LRB-
cord-003302-vxk7uqlc	220	17	9	9	CD
cord-003302-vxk7uqlc	220	18	]	]	-RRB-
cord-003302-vxk7uqlc	220	19	.	.	.
cord-003302-vxk7uqlc	221	1	Moreover	moreover	RB
cord-003302-vxk7uqlc	221	2	,	,	,
cord-003302-vxk7uqlc	221	3	when	when	WRB
cord-003302-vxk7uqlc	221	4	they	-PRON-	PRP
cord-003302-vxk7uqlc	221	5	eventually	eventually	RB
cord-003302-vxk7uqlc	221	6	become	become	VBP
cord-003302-vxk7uqlc	221	7	available	available	JJ
cord-003302-vxk7uqlc	221	8	,	,	,
cord-003302-vxk7uqlc	221	9	it	-PRON-	PRP
cord-003302-vxk7uqlc	221	10	is	be	VBZ
cord-003302-vxk7uqlc	221	11	unlikely	unlikely	JJ
cord-003302-vxk7uqlc	221	12	they	-PRON-	PRP
cord-003302-vxk7uqlc	221	13	will	will	MD
cord-003302-vxk7uqlc	221	14	be	be	VB
cord-003302-vxk7uqlc	221	15	equitably	equitably	RB
cord-003302-vxk7uqlc	221	16	distributed	distribute	VBN
cord-003302-vxk7uqlc	221	17	to	to	IN
cord-003302-vxk7uqlc	221	18	low	low	JJ
cord-003302-vxk7uqlc	221	19	-	-	HYPH
cord-003302-vxk7uqlc	221	20	and	and	CC
cord-003302-vxk7uqlc	221	21	middle	middle	JJ
cord-003302-vxk7uqlc	221	22	-	-	HYPH
cord-003302-vxk7uqlc	221	23	income	income	NN
cord-003302-vxk7uqlc	221	24	countries	country	NNS
cord-003302-vxk7uqlc	221	25	that	that	WDT
cord-003302-vxk7uqlc	221	26	do	do	VBP
cord-003302-vxk7uqlc	221	27	n't	not	RB
cord-003302-vxk7uqlc	221	28	produce	produce	VB
cord-003302-vxk7uqlc	221	29	their	-PRON-	PRP$
cord-003302-vxk7uqlc	221	30	own	own	JJ
cord-003302-vxk7uqlc	221	31	influenza	influenza	NN
cord-003302-vxk7uqlc	221	32	vaccines	vaccine	NNS
cord-003302-vxk7uqlc	221	33	[	[	-LRB-
cord-003302-vxk7uqlc	221	34	81	81	CD
cord-003302-vxk7uqlc	221	35	]	]	-RRB-
cord-003302-vxk7uqlc	221	36	.	.	.
cord-003302-vxk7uqlc	222	1	Antiviral	antiviral	JJ
cord-003302-vxk7uqlc	222	2	treatment	treatment	NN
cord-003302-vxk7uqlc	222	3	of	of	IN
cord-003302-vxk7uqlc	222	4	individual	individual	JJ
cord-003302-vxk7uqlc	222	5	pandemic	pandemic	NN
cord-003302-vxk7uqlc	222	6	patients	patient	NNS
cord-003302-vxk7uqlc	222	7	could	could	MD
cord-003302-vxk7uqlc	222	8	also	also	RB
cord-003302-vxk7uqlc	222	9	be	be	VB
cord-003302-vxk7uqlc	222	10	problematic	problematic	JJ
cord-003302-vxk7uqlc	222	11	.	.	.
cord-003302-vxk7uqlc	223	1	Supplies	supply	NNS
cord-003302-vxk7uqlc	223	2	of	of	IN
cord-003302-vxk7uqlc	223	3	one	one	CD
cord-003302-vxk7uqlc	223	4	of	of	IN
cord-003302-vxk7uqlc	223	5	the	the	DT
cord-003302-vxk7uqlc	223	6	drugs	drug	NNS
cord-003302-vxk7uqlc	223	7	(	(	-LRB-
cord-003302-vxk7uqlc	223	8	oseltamivir	oseltamivir	NNP
cord-003302-vxk7uqlc	223	9	)	)	-RRB-
cord-003302-vxk7uqlc	223	10	are	be	VBP
cord-003302-vxk7uqlc	223	11	limited	limit	VBN
cord-003302-vxk7uqlc	223	12	and	and	CC
cord-003302-vxk7uqlc	223	13	the	the	DT
cord-003302-vxk7uqlc	223	14	drug	drug	NN
cord-003302-vxk7uqlc	223	15	is	be	VBZ
cord-003302-vxk7uqlc	223	16	not	not	RB
cord-003302-vxk7uqlc	223	17	widely	widely	RB
cord-003302-vxk7uqlc	223	18	used	use	VBN
cord-003302-vxk7uqlc	223	19	.	.	.
cord-003302-vxk7uqlc	224	1	There	there	EX
cord-003302-vxk7uqlc	224	2	is	be	VBZ
cord-003302-vxk7uqlc	224	3	also	also	RB
cord-003302-vxk7uqlc	224	4	concern	concern	NN
cord-003302-vxk7uqlc	224	5	about	about	IN
cord-003302-vxk7uqlc	224	6	the	the	DT
cord-003302-vxk7uqlc	224	7	development	development	NN
cord-003302-vxk7uqlc	224	8	of	of	IN
cord-003302-vxk7uqlc	224	9	antiviral	antiviral	JJ
cord-003302-vxk7uqlc	224	10	resistance	resistance	NN
cord-003302-vxk7uqlc	224	11	.	.	.
cord-003302-vxk7uqlc	225	1	Moreover	moreover	RB
cord-003302-vxk7uqlc	225	2	,	,	,
cord-003302-vxk7uqlc	225	3	a	a	DT
cord-003302-vxk7uqlc	225	4	recent	recent	JJ
cord-003302-vxk7uqlc	225	5	report	report	NN
cord-003302-vxk7uqlc	225	6	on	on	IN
cord-003302-vxk7uqlc	225	7	1220	1220	CD
cord-003302-vxk7uqlc	225	8	patients	patient	NNS
cord-003302-vxk7uqlc	225	9	hospitalized	hospitalize	VBN
cord-003302-vxk7uqlc	225	10	in	in	IN
cord-003302-vxk7uqlc	225	11	China	China	NNP
cord-003302-vxk7uqlc	225	12	with	with	IN
cord-003302-vxk7uqlc	225	13	laboratoryconfirmed	laboratoryconfirme	VBN
cord-003302-vxk7uqlc	225	14	H7N9	H7N9	NNP
cord-003302-vxk7uqlc	225	15	influenza	influenza	NN
cord-003302-vxk7uqlc	225	16	showed	show	VBD
cord-003302-vxk7uqlc	225	17	that	that	IN
cord-003302-vxk7uqlc	225	18	although	although	IN
cord-003302-vxk7uqlc	225	19	70	70	CD
cord-003302-vxk7uqlc	225	20	%	%	NN
cord-003302-vxk7uqlc	225	21	of	of	IN
cord-003302-vxk7uqlc	225	22	all	all	DT
cord-003302-vxk7uqlc	225	23	patients	patient	NNS
cord-003302-vxk7uqlc	225	24	were	be	VBD
cord-003302-vxk7uqlc	225	25	treated	treat	VBN
cord-003302-vxk7uqlc	225	26	with	with	IN
cord-003302-vxk7uqlc	225	27	oseltamivir	oseltamivir	NN
cord-003302-vxk7uqlc	225	28	,	,	,
cord-003302-vxk7uqlc	225	29	case	case	NN
cord-003302-vxk7uqlc	225	30	fatality	fatality	NN
cord-003302-vxk7uqlc	225	31	rates	rate	NNS
cord-003302-vxk7uqlc	225	32	were	be	VBD
cord-003302-vxk7uqlc	225	33	still	still	RB
cord-003302-vxk7uqlc	225	34	40	40	CD
cord-003302-vxk7uqlc	225	35	%	%	NN
cord-003302-vxk7uqlc	225	36	[	[	-LRB-
cord-003302-vxk7uqlc	225	37	82	82	CD
cord-003302-vxk7uqlc	225	38	]	]	-RRB-
cord-003302-vxk7uqlc	225	39	.	.	.
cord-003302-vxk7uqlc	226	1	An	an	DT
cord-003302-vxk7uqlc	226	2	alternative	alternative	JJ
cord-003302-vxk7uqlc	226	3	strategy	strategy	NN
cord-003302-vxk7uqlc	226	4	for	for	IN
cord-003302-vxk7uqlc	226	5	reducing	reduce	VBG
cord-003302-vxk7uqlc	226	6	pandemic	pandemic	NN
cord-003302-vxk7uqlc	226	7	mortality	mortality	NN
cord-003302-vxk7uqlc	226	8	would	would	MD
cord-003302-vxk7uqlc	226	9	be	be	VB
cord-003302-vxk7uqlc	226	10	to	to	TO
cord-003302-vxk7uqlc	226	11	develop	develop	VB
cord-003302-vxk7uqlc	226	12	effective	effective	JJ
cord-003302-vxk7uqlc	226	13	treatments	treatment	NNS
cord-003302-vxk7uqlc	226	14	that	that	WDT
cord-003302-vxk7uqlc	226	15	target	target	VBP
cord-003302-vxk7uqlc	226	16	the	the	DT
cord-003302-vxk7uqlc	226	17	host	host	NN
cord-003302-vxk7uqlc	226	18	response	response	NN
cord-003302-vxk7uqlc	226	19	of	of	IN
cord-003302-vxk7uqlc	226	20	patients	patient	NNS
cord-003302-vxk7uqlc	226	21	who	who	WP
cord-003302-vxk7uqlc	226	22	develop	develop	VBP
cord-003302-vxk7uqlc	226	23	severe	severe	JJ
cord-003302-vxk7uqlc	226	24	illness	illness	NN
cord-003302-vxk7uqlc	226	25	[	[	-LRB-
cord-003302-vxk7uqlc	226	26	2	2	CD
cord-003302-vxk7uqlc	226	27	]	]	-RRB-
cord-003302-vxk7uqlc	226	28	[	[	-LRB-
cord-003302-vxk7uqlc	226	29	3	3	CD
cord-003302-vxk7uqlc	226	30	]	]	-RRB-
cord-003302-vxk7uqlc	226	31	[	[	-LRB-
cord-003302-vxk7uqlc	226	32	4	4	CD
cord-003302-vxk7uqlc	226	33	]	]	-RRB-
cord-003302-vxk7uqlc	226	34	[	[	-LRB-
cord-003302-vxk7uqlc	226	35	5	5	CD
cord-003302-vxk7uqlc	226	36	]	]	-RRB-
cord-003302-vxk7uqlc	226	37	[	[	-LRB-
cord-003302-vxk7uqlc	226	38	6	6	CD
cord-003302-vxk7uqlc	226	39	]	]	-RRB-
cord-003302-vxk7uqlc	226	40	[	[	-LRB-
cord-003302-vxk7uqlc	226	41	7	7	CD
cord-003302-vxk7uqlc	226	42	]	]	-RRB-
cord-003302-vxk7uqlc	226	43	[	[	-LRB-
cord-003302-vxk7uqlc	226	44	8	8	CD
cord-003302-vxk7uqlc	226	45	]	]	-RRB-
cord-003302-vxk7uqlc	226	46	[	[	-LRB-
cord-003302-vxk7uqlc	226	47	9	9	CD
cord-003302-vxk7uqlc	226	48	]	]	-RRB-
cord-003302-vxk7uqlc	226	49	.	.	.
cord-003302-vxk7uqlc	227	1	These	these	DT
cord-003302-vxk7uqlc	227	2	drugs	drug	NNS
cord-003302-vxk7uqlc	227	3	might	may	MD
cord-003302-vxk7uqlc	227	4	have	have	VB
cord-003302-vxk7uqlc	227	5	some	some	DT
cord-003302-vxk7uqlc	227	6	effect	effect	NN
cord-003302-vxk7uqlc	227	7	on	on	IN
cord-003302-vxk7uqlc	227	8	the	the	DT
cord-003302-vxk7uqlc	227	9	development	development	NN
cord-003302-vxk7uqlc	227	10	of	of	IN
cord-003302-vxk7uqlc	227	11	symptomatic	symptomatic	JJ
cord-003302-vxk7uqlc	227	12	illness	illness	NN
cord-003302-vxk7uqlc	227	13	[	[	-LRB-
cord-003302-vxk7uqlc	227	14	83	83	CD
cord-003302-vxk7uqlc	227	15	]	]	-RRB-
cord-003302-vxk7uqlc	227	16	,	,	,
cord-003302-vxk7uqlc	227	17	but	but	CC
cord-003302-vxk7uqlc	227	18	their	-PRON-	PRP$
cord-003302-vxk7uqlc	227	19	potential	potential	JJ
cord-003302-vxk7uqlc	227	20	impact	impact	NN
cord-003302-vxk7uqlc	227	21	on	on	IN
cord-003302-vxk7uqlc	227	22	pandemic	pandemic	JJ
cord-003302-vxk7uqlc	227	23	mortality	mortality	NN
cord-003302-vxk7uqlc	227	24	would	would	MD
cord-003302-vxk7uqlc	227	25	be	be	VB
cord-003302-vxk7uqlc	227	26	far	far	RB
cord-003302-vxk7uqlc	227	27	more	more	RBR
cord-003302-vxk7uqlc	227	28	important	important	JJ
cord-003302-vxk7uqlc	227	29	.	.	.
cord-003302-vxk7uqlc	228	1	Agendas	agenda	NNS
cord-003302-vxk7uqlc	228	2	for	for	IN
cord-003302-vxk7uqlc	228	3	laboratory	laboratory	NN
cord-003302-vxk7uqlc	228	4	and	and	CC
cord-003302-vxk7uqlc	228	5	clinical	clinical	JJ
cord-003302-vxk7uqlc	228	6	research	research	NN
cord-003302-vxk7uqlc	228	7	to	to	TO
cord-003302-vxk7uqlc	228	8	evaluate	evaluate	VB
cord-003302-vxk7uqlc	228	9	their	-PRON-	PRP$
cord-003302-vxk7uqlc	228	10	potential	potential	JJ
cord-003302-vxk7uqlc	228	11	have	have	VBP
cord-003302-vxk7uqlc	228	12	been	be	VBN
cord-003302-vxk7uqlc	228	13	published	publish	VBN
cord-003302-vxk7uqlc	228	14	in	in	IN
cord-003302-vxk7uqlc	228	15	several	several	JJ
cord-003302-vxk7uqlc	228	16	articles	article	NNS
cord-003302-vxk7uqlc	228	17	(	(	-LRB-
cord-003302-vxk7uqlc	228	18	Table	table	NN
cord-003302-vxk7uqlc	228	19	6	6	CD
cord-003302-vxk7uqlc	228	20	in	in	IN
cord-003302-vxk7uqlc	228	21	reference	reference	NN
cord-003302-vxk7uqlc	228	22	8	8	CD
cord-003302-vxk7uqlc	228	23	,	,	,
cord-003302-vxk7uqlc	228	24	Table	table	NN
cord-003302-vxk7uqlc	228	25	1	1	CD
cord-003302-vxk7uqlc	228	26	in	in	IN
cord-003302-vxk7uqlc	228	27	reference	reference	NN
cord-003302-vxk7uqlc	228	28	9	9	CD
cord-003302-vxk7uqlc	228	29	,	,	,
cord-003302-vxk7uqlc	228	30	and	and	CC
cord-003302-vxk7uqlc	228	31	more	more	RBR
cord-003302-vxk7uqlc	228	32	generally	generally	RB
cord-003302-vxk7uqlc	228	33	in	in	IN
cord-003302-vxk7uqlc	228	34	references	reference	NNS
cord-003302-vxk7uqlc	228	35	2	2	CD
cord-003302-vxk7uqlc	228	36	and	and	CC
cord-003302-vxk7uqlc	228	37	4	4	CD
cord-003302-vxk7uqlc	228	38	-	-	SYM
cord-003302-vxk7uqlc	228	39	6	6	CD
cord-003302-vxk7uqlc	228	40	)	)	-RRB-
cord-003302-vxk7uqlc	228	41	.	.	.
cord-003302-vxk7uqlc	229	1	Although	although	IN
cord-003302-vxk7uqlc	229	2	influenza	influenza	NN
cord-003302-vxk7uqlc	229	3	scientists	scientist	NNS
cord-003302-vxk7uqlc	229	4	often	often	RB
cord-003302-vxk7uqlc	229	5	regard	regard	VBP
cord-003302-vxk7uqlc	229	6	host	host	NN
cord-003302-vxk7uqlc	229	7	response	response	NN
cord-003302-vxk7uqlc	229	8	treatment	treatment	NN
cord-003302-vxk7uqlc	229	9	as	as	IN
cord-003302-vxk7uqlc	229	10	an	an	DT
cord-003302-vxk7uqlc	229	11	adjunct	adjunct	NN
cord-003302-vxk7uqlc	229	12	to	to	IN
cord-003302-vxk7uqlc	229	13	antivirals	antiviral	NNS
cord-003302-vxk7uqlc	229	14	[	[	-LRB-
cord-003302-vxk7uqlc	229	15	84	84	CD
cord-003302-vxk7uqlc	229	16	]	]	-RRB-
cord-003302-vxk7uqlc	229	17	,	,	,
cord-003302-vxk7uqlc	229	18	some	some	DT
cord-003302-vxk7uqlc	229	19	of	of	IN
cord-003302-vxk7uqlc	229	20	this	this	DT
cord-003302-vxk7uqlc	229	21	research	research	NN
cord-003302-vxk7uqlc	229	22	must	must	MD
cord-003302-vxk7uqlc	229	23	be	be	VB
cord-003302-vxk7uqlc	229	24	limited	limit	VBN
cord-003302-vxk7uqlc	229	25	to	to	IN
cord-003302-vxk7uqlc	229	26	generic	generic	JJ
cord-003302-vxk7uqlc	229	27	drugs	drug	NNS
cord-003302-vxk7uqlc	229	28	that	that	WDT
cord-003302-vxk7uqlc	229	29	target	target	VBP
cord-003302-vxk7uqlc	229	30	the	the	DT
cord-003302-vxk7uqlc	229	31	host	host	NN
cord-003302-vxk7uqlc	229	32	response	response	NN
cord-003302-vxk7uqlc	229	33	because	because	IN
cord-003302-vxk7uqlc	229	34	most	most	JJS
cord-003302-vxk7uqlc	229	35	of	of	IN
cord-003302-vxk7uqlc	229	36	the	the	DT
cord-003302-vxk7uqlc	229	37	world	world	NN
cord-003302-vxk7uqlc	229	38	's	's	POS
cord-003302-vxk7uqlc	229	39	people	people	NNS
cord-003302-vxk7uqlc	229	40	wo	will	MD
cord-003302-vxk7uqlc	229	41	n't	not	RB
cord-003302-vxk7uqlc	229	42	have	have	VB
cord-003302-vxk7uqlc	229	43	access	access	NN
cord-003302-vxk7uqlc	229	44	to	to	IN
cord-003302-vxk7uqlc	229	45	antivirals	antiviral	NNS
cord-003302-vxk7uqlc	229	46	but	but	CC
cord-003302-vxk7uqlc	229	47	will	will	MD
cord-003302-vxk7uqlc	229	48	have	have	VB
cord-003302-vxk7uqlc	229	49	access	access	NN
cord-003302-vxk7uqlc	229	50	to	to	IN
cord-003302-vxk7uqlc	229	51	generics	generic	NNS
cord-003302-vxk7uqlc	229	52	.	.	.
cord-003302-vxk7uqlc	230	1	These	these	DT
cord-003302-vxk7uqlc	230	2	studies	study	NNS
cord-003302-vxk7uqlc	230	3	must	must	MD
cord-003302-vxk7uqlc	230	4	go	go	VB
cord-003302-vxk7uqlc	230	5	beyond	beyond	IN
cord-003302-vxk7uqlc	230	6	documenting	document	VBG
cord-003302-vxk7uqlc	230	7	cytokine	cytokine	NN
cord-003302-vxk7uqlc	230	8	responses	response	NNS
cord-003302-vxk7uqlc	230	9	following	follow	VBG
cord-003302-vxk7uqlc	230	10	infection	infection	NN
cord-003302-vxk7uqlc	230	11	and	and	CC
cord-003302-vxk7uqlc	230	12	examine	examine	VB
cord-003302-vxk7uqlc	230	13	immunometabolic	immunometabolic	JJ
cord-003302-vxk7uqlc	230	14	and	and	CC
cord-003302-vxk7uqlc	230	15	epigenetic	epigenetic	JJ
cord-003302-vxk7uqlc	230	16	factors	factor	NNS
cord-003302-vxk7uqlc	230	17	that	that	WDT
cord-003302-vxk7uqlc	230	18	affect	affect	VBP
cord-003302-vxk7uqlc	230	19	(	(	-LRB-
cord-003302-vxk7uqlc	230	20	among	among	IN
cord-003302-vxk7uqlc	230	21	other	other	JJ
cord-003302-vxk7uqlc	230	22	things	thing	NNS
cord-003302-vxk7uqlc	230	23	)	)	-RRB-
cord-003302-vxk7uqlc	230	24	cellular	cellular	JJ
cord-003302-vxk7uqlc	230	25	immunity	immunity	NN
cord-003302-vxk7uqlc	230	26	,	,	,
cord-003302-vxk7uqlc	230	27	endothelial	endothelial	JJ
cord-003302-vxk7uqlc	230	28	function	function	NN
cord-003302-vxk7uqlc	230	29	and	and	CC
cord-003302-vxk7uqlc	230	30	energy	energy	NN
cord-003302-vxk7uqlc	230	31	metabolism	metabolism	NN
cord-003302-vxk7uqlc	230	32	[	[	-LRB-
cord-003302-vxk7uqlc	230	33	8	8	CD
cord-003302-vxk7uqlc	230	34	,	,	,
cord-003302-vxk7uqlc	230	35	9	9	CD
cord-003302-vxk7uqlc	230	36	]	]	-RRB-
cord-003302-vxk7uqlc	230	37	.	.	.
cord-003302-vxk7uqlc	231	1	All	all	DT
cord-003302-vxk7uqlc	231	2	of	of	IN
cord-003302-vxk7uqlc	231	3	these	these	DT
cord-003302-vxk7uqlc	231	4	studies	study	NNS
cord-003302-vxk7uqlc	231	5	should	should	MD
cord-003302-vxk7uqlc	231	6	include	include	VB
cord-003302-vxk7uqlc	231	7	comparisons	comparison	NNS
cord-003302-vxk7uqlc	231	8	before	before	IN
cord-003302-vxk7uqlc	231	9	and	and	CC
cord-003302-vxk7uqlc	231	10	after	after	IN
cord-003302-vxk7uqlc	231	11	puberty	puberty	NN
cord-003302-vxk7uqlc	231	12	.	.	.
cord-003302-vxk7uqlc	232	1	Treating	treat	VBG
cord-003302-vxk7uqlc	232	2	the	the	DT
cord-003302-vxk7uqlc	232	3	host	host	NN
cord-003302-vxk7uqlc	232	4	response	response	NN
cord-003302-vxk7uqlc	232	5	holds	hold	VBZ
cord-003302-vxk7uqlc	232	6	promise	promise	NN
cord-003302-vxk7uqlc	232	7	for	for	IN
cord-003302-vxk7uqlc	232	8	not	not	RB
cord-003302-vxk7uqlc	232	9	only	only	RB
cord-003302-vxk7uqlc	232	10	reducing	reduce	VBG
cord-003302-vxk7uqlc	232	11	pandemic	pandemic	NN
cord-003302-vxk7uqlc	232	12	mortality	mortality	NN
cord-003302-vxk7uqlc	232	13	but	but	CC
cord-003302-vxk7uqlc	232	14	also	also	RB
cord-003302-vxk7uqlc	232	15	for	for	IN
cord-003302-vxk7uqlc	232	16	reducing	reduce	VBG
cord-003302-vxk7uqlc	232	17	the	the	DT
cord-003302-vxk7uqlc	232	18	appreciable	appreciable	JJ
cord-003302-vxk7uqlc	232	19	mortality	mortality	NN
cord-003302-vxk7uqlc	232	20	associated	associate	VBN
cord-003302-vxk7uqlc	232	21	with	with	IN
cord-003302-vxk7uqlc	232	22	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	232	23	influenza	influenza	NN
cord-003302-vxk7uqlc	232	24	and	and	CC
cord-003302-vxk7uqlc	232	25	other	other	JJ
cord-003302-vxk7uqlc	232	26	forms	form	NNS
cord-003302-vxk7uqlc	232	27	of	of	IN
cord-003302-vxk7uqlc	232	28	acute	acute	JJ
cord-003302-vxk7uqlc	232	29	critical	critical	JJ
cord-003302-vxk7uqlc	232	30	illness	illness	NN
cord-003302-vxk7uqlc	232	31	(	(	-LRB-
cord-003302-vxk7uqlc	232	32	e.g.	e.g.	RB
cord-003302-vxk7uqlc	232	33	,	,	,
cord-003302-vxk7uqlc	232	34	Ebola	Ebola	NNP
cord-003302-vxk7uqlc	232	35	virus	virus	NN
cord-003302-vxk7uqlc	232	36	disease	disease	NN
cord-003302-vxk7uqlc	232	37	[	[	-LRB-
cord-003302-vxk7uqlc	232	38	8	8	CD
cord-003302-vxk7uqlc	232	39	]	]	-RRB-
cord-003302-vxk7uqlc	232	40	)	)	-RRB-
cord-003302-vxk7uqlc	232	41	.	.	.
cord-003302-vxk7uqlc	233	1	Many	many	JJ
cord-003302-vxk7uqlc	233	2	of	of	IN
cord-003302-vxk7uqlc	233	3	the	the	DT
cord-003302-vxk7uqlc	233	4	candidate	candidate	NN
cord-003302-vxk7uqlc	233	5	drugs	drug	NNS
cord-003302-vxk7uqlc	233	6	are	be	VBP
cord-003302-vxk7uqlc	233	7	produced	produce	VBN
cord-003302-vxk7uqlc	233	8	as	as	IN
cord-003302-vxk7uqlc	233	9	generics	generic	NNS
cord-003302-vxk7uqlc	233	10	in	in	IN
cord-003302-vxk7uqlc	233	11	developing	develop	VBG
cord-003302-vxk7uqlc	233	12	countries	country	NNS
cord-003302-vxk7uqlc	233	13	,	,	,
cord-003302-vxk7uqlc	233	14	and	and	CC
cord-003302-vxk7uqlc	233	15	supply	supply	VB
cord-003302-vxk7uqlc	233	16	chains	chain	NNS
cord-003302-vxk7uqlc	233	17	for	for	IN
cord-003302-vxk7uqlc	233	18	their	-PRON-	PRP$
cord-003302-vxk7uqlc	233	19	worldwide	worldwide	JJ
cord-003302-vxk7uqlc	233	20	delivery	delivery	NN
cord-003302-vxk7uqlc	233	21	are	be	VBP
cord-003302-vxk7uqlc	233	22	already	already	RB
cord-003302-vxk7uqlc	233	23	in	in	IN
cord-003302-vxk7uqlc	233	24	place	place	NN
cord-003302-vxk7uqlc	233	25	[	[	-LRB-
cord-003302-vxk7uqlc	233	26	5	5	CD
cord-003302-vxk7uqlc	233	27	]	]	-RRB-
cord-003302-vxk7uqlc	233	28	[	[	-LRB-
cord-003302-vxk7uqlc	233	29	6	6	CD
cord-003302-vxk7uqlc	233	30	]	]	-RRB-
cord-003302-vxk7uqlc	233	31	[	[	-LRB-
cord-003302-vxk7uqlc	233	32	7	7	CD
cord-003302-vxk7uqlc	233	33	]	]	-RRB-
cord-003302-vxk7uqlc	233	34	[	[	-LRB-
cord-003302-vxk7uqlc	233	35	8	8	CD
cord-003302-vxk7uqlc	233	36	]	]	-RRB-
cord-003302-vxk7uqlc	233	37	[	[	-LRB-
cord-003302-vxk7uqlc	233	38	9	9	CD
cord-003302-vxk7uqlc	233	39	]	]	-RRB-
cord-003302-vxk7uqlc	233	40	.	.	.
cord-003302-vxk7uqlc	234	1	Physicians	physician	NNS
cord-003302-vxk7uqlc	234	2	are	be	VBP
cord-003302-vxk7uqlc	234	3	familiar	familiar	JJ
cord-003302-vxk7uqlc	234	4	with	with	IN
cord-003302-vxk7uqlc	234	5	these	these	DT
cord-003302-vxk7uqlc	234	6	drugs	drug	NNS
cord-003302-vxk7uqlc	234	7	because	because	IN
cord-003302-vxk7uqlc	234	8	they	-PRON-	PRP
cord-003302-vxk7uqlc	234	9	use	use	VBP
cord-003302-vxk7uqlc	234	10	them	-PRON-	PRP
cord-003302-vxk7uqlc	234	11	every	every	DT
cord-003302-vxk7uqlc	234	12	day	day	NN
cord-003302-vxk7uqlc	234	13	.	.	.
cord-003302-vxk7uqlc	235	1	If	if	IN
cord-003302-vxk7uqlc	235	2	this	this	DT
cord-003302-vxk7uqlc	235	3	treatment	treatment	NN
cord-003302-vxk7uqlc	235	4	strategy	strategy	NN
cord-003302-vxk7uqlc	235	5	were	be	VBD
cord-003302-vxk7uqlc	235	6	shown	show	VBN
cord-003302-vxk7uqlc	235	7	to	to	TO
cord-003302-vxk7uqlc	235	8	work	work	VB
cord-003302-vxk7uqlc	235	9	,	,	,
cord-003302-vxk7uqlc	235	10	it	-PRON-	PRP
cord-003302-vxk7uqlc	235	11	could	could	MD
cord-003302-vxk7uqlc	235	12	be	be	VB
cord-003302-vxk7uqlc	235	13	used	use	VBN
cord-003302-vxk7uqlc	235	14	in	in	IN
cord-003302-vxk7uqlc	235	15	any	any	DT
cord-003302-vxk7uqlc	235	16	country	country	NN
cord-003302-vxk7uqlc	235	17	with	with	IN
cord-003302-vxk7uqlc	235	18	a	a	DT
cord-003302-vxk7uqlc	235	19	basic	basic	JJ
cord-003302-vxk7uqlc	235	20	healthcare	healthcare	NN
cord-003302-vxk7uqlc	235	21	system	system	NN
cord-003302-vxk7uqlc	235	22	.	.	.
cord-003302-vxk7uqlc	236	1	For	for	IN
cord-003302-vxk7uqlc	236	2	a	a	DT
cord-003302-vxk7uqlc	236	3	pandemic	pandemic	NN
cord-003302-vxk7uqlc	236	4	,	,	,
cord-003302-vxk7uqlc	236	5	treatment	treatment	NN
cord-003302-vxk7uqlc	236	6	could	could	MD
cord-003302-vxk7uqlc	236	7	start	start	VB
cord-003302-vxk7uqlc	236	8	in	in	IN
cord-003302-vxk7uqlc	236	9	all	all	DT
cord-003302-vxk7uqlc	236	10	countries	country	NNS
cord-003302-vxk7uqlc	236	11	on	on	IN
cord-003302-vxk7uqlc	236	12	the	the	DT
cord-003302-vxk7uqlc	236	13	first	first	JJ
cord-003302-vxk7uqlc	236	14	pandemic	pandemic	NN
cord-003302-vxk7uqlc	236	15	day	day	NN
cord-003302-vxk7uqlc	236	16	.	.	.
cord-003302-vxk7uqlc	237	1	Influenza	influenza	NN
cord-003302-vxk7uqlc	237	2	virologists	virologist	NNS
cord-003302-vxk7uqlc	237	3	have	have	VBP
cord-003302-vxk7uqlc	237	4	expanded	expand	VBN
cord-003302-vxk7uqlc	237	5	our	-PRON-	PRP$
cord-003302-vxk7uqlc	237	6	understanding	understanding	NN
cord-003302-vxk7uqlc	237	7	of	of	IN
cord-003302-vxk7uqlc	237	8	the	the	DT
cord-003302-vxk7uqlc	237	9	molecular	molecular	JJ
cord-003302-vxk7uqlc	237	10	biology	biology	NN
cord-003302-vxk7uqlc	237	11	and	and	CC
cord-003302-vxk7uqlc	237	12	epidemiology	epidemiology	NN
cord-003302-vxk7uqlc	237	13	of	of	IN
cord-003302-vxk7uqlc	237	14	influenza	influenza	NN
cord-003302-vxk7uqlc	237	15	viruses	virus	NNS
cord-003302-vxk7uqlc	237	16	.	.	.
cord-003302-vxk7uqlc	238	1	Laboratory	laboratory	NN
cord-003302-vxk7uqlc	238	2	and	and	CC
cord-003302-vxk7uqlc	238	3	clinical	clinical	JJ
cord-003302-vxk7uqlc	238	4	investigators	investigator	NNS
cord-003302-vxk7uqlc	238	5	have	have	VBP
cord-003302-vxk7uqlc	238	6	deepened	deepen	VBN
cord-003302-vxk7uqlc	238	7	our	-PRON-	PRP$
cord-003302-vxk7uqlc	238	8	understanding	understanding	NN
cord-003302-vxk7uqlc	238	9	of	of	IN
cord-003302-vxk7uqlc	238	10	the	the	DT
cord-003302-vxk7uqlc	238	11	host	host	NN
cord-003302-vxk7uqlc	238	12	response	response	NN
cord-003302-vxk7uqlc	238	13	to	to	IN
cord-003302-vxk7uqlc	238	14	critical	critical	JJ
cord-003302-vxk7uqlc	238	15	illness	illness	NN
cord-003302-vxk7uqlc	238	16	.	.	.
cord-003302-vxk7uqlc	239	1	Evolutionary	evolutionary	JJ
cord-003302-vxk7uqlc	239	2	biologists	biologist	NNS
cord-003302-vxk7uqlc	239	3	have	have	VBP
cord-003302-vxk7uqlc	239	4	suggested	suggest	VBN
cord-003302-vxk7uqlc	239	5	that	that	IN
cord-003302-vxk7uqlc	239	6	evolution	evolution	NN
cord-003302-vxk7uqlc	239	7	provides	provide	VBZ
cord-003302-vxk7uqlc	239	8	insights	insight	NNS
cord-003302-vxk7uqlc	239	9	that	that	WDT
cord-003302-vxk7uqlc	239	10	could	could	MD
cord-003302-vxk7uqlc	239	11	help	help	VB
cord-003302-vxk7uqlc	239	12	public	public	JJ
cord-003302-vxk7uqlc	239	13	health	health	NN
cord-003302-vxk7uqlc	239	14	.	.	.
cord-003302-vxk7uqlc	240	1	All	all	DT
cord-003302-vxk7uqlc	240	2	of	of	IN
cord-003302-vxk7uqlc	240	3	these	these	DT
cord-003302-vxk7uqlc	240	4	developments	development	NNS
cord-003302-vxk7uqlc	240	5	should	should	MD
cord-003302-vxk7uqlc	240	6	shape	shape	VB
cord-003302-vxk7uqlc	240	7	the	the	DT
cord-003302-vxk7uqlc	240	8	way	way	NN
cord-003302-vxk7uqlc	240	9	we	-PRON-	PRP
cord-003302-vxk7uqlc	240	10	respond	respond	VBP
cord-003302-vxk7uqlc	240	11	to	to	IN
cord-003302-vxk7uqlc	240	12	the	the	DT
cord-003302-vxk7uqlc	240	13	next	next	JJ
cord-003302-vxk7uqlc	240	14	influenza	influenza	NN
cord-003302-vxk7uqlc	240	15	pandemic	pandemic	NN
cord-003302-vxk7uqlc	240	16	.	.	.
cord-003302-vxk7uqlc	241	1	Charles	Charles	NNP
cord-003302-vxk7uqlc	241	2	Darwin	Darwin	NNP
cord-003302-vxk7uqlc	241	3	wrote	write	VBD
cord-003302-vxk7uqlc	241	4	"	"	''
cord-003302-vxk7uqlc	241	5	.	.	.
cord-003302-vxk7uqlc	241	6	.	.	.
cord-003302-vxk7uqlc	241	7	.	.	.
cord-003302-vxk7uqlc	242	1	observation	observation	NN
cord-003302-vxk7uqlc	242	2	must	must	MD
cord-003302-vxk7uqlc	242	3	be	be	VB
cord-003302-vxk7uqlc	242	4	for	for	IN
cord-003302-vxk7uqlc	242	5	or	or	CC
cord-003302-vxk7uqlc	242	6	against	against	IN
cord-003302-vxk7uqlc	242	7	some	some	DT
cord-003302-vxk7uqlc	242	8	view	view	NN
cord-003302-vxk7uqlc	242	9	if	if	IN
cord-003302-vxk7uqlc	242	10	it	-PRON-	PRP
cord-003302-vxk7uqlc	242	11	is	be	VBZ
cord-003302-vxk7uqlc	242	12	to	to	TO
cord-003302-vxk7uqlc	242	13	be	be	VB
cord-003302-vxk7uqlc	242	14	of	of	IN
cord-003302-vxk7uqlc	242	15	any	any	DT
cord-003302-vxk7uqlc	242	16	service	service	NN
cord-003302-vxk7uqlc	242	17	"	"	''
cord-003302-vxk7uqlc	242	18	[	[	-LRB-
cord-003302-vxk7uqlc	242	19	85	85	CD
cord-003302-vxk7uqlc	242	20	]	]	-RRB-
cord-003302-vxk7uqlc	242	21	.	.	.
cord-003302-vxk7uqlc	243	1	His	-PRON-	PRP$
cord-003302-vxk7uqlc	243	2	view	view	NN
cord-003302-vxk7uqlc	243	3	-the	-the	DT
cord-003302-vxk7uqlc	243	4	hypothesis	hypothesis	NN
cord-003302-vxk7uqlc	243	5	that	that	IN
cord-003302-vxk7uqlc	243	6	evolution	evolution	NN
cord-003302-vxk7uqlc	243	7	is	be	VBZ
cord-003302-vxk7uqlc	243	8	guided	guide	VBN
cord-003302-vxk7uqlc	243	9	by	by	IN
cord-003302-vxk7uqlc	243	10	natural	natural	JJ
cord-003302-vxk7uqlc	243	11	selection	selection	NN
cord-003302-vxk7uqlc	243	12	-was	-was	:
cord-003302-vxk7uqlc	243	13	supported	support	VBN
cord-003302-vxk7uqlc	243	14	by	by	IN
cord-003302-vxk7uqlc	243	15	extensive	extensive	JJ
cord-003302-vxk7uqlc	243	16	observations	observation	NNS
cord-003302-vxk7uqlc	243	17	made	make	VBN
cord-003302-vxk7uqlc	243	18	over	over	IN
cord-003302-vxk7uqlc	243	19	several	several	JJ
cord-003302-vxk7uqlc	243	20	decades	decade	NNS
cord-003302-vxk7uqlc	243	21	,	,	,
cord-003302-vxk7uqlc	243	22	and	and	CC
cord-003302-vxk7uqlc	243	23	its	-PRON-	PRP$
cord-003302-vxk7uqlc	243	24	explanatory	explanatory	JJ
cord-003302-vxk7uqlc	243	25	power	power	NN
cord-003302-vxk7uqlc	243	26	(	(	-LRB-
cord-003302-vxk7uqlc	243	27	i.e.	i.e.	FW
cord-003302-vxk7uqlc	243	28	,	,	,
cord-003302-vxk7uqlc	243	29	'	'	''
cord-003302-vxk7uqlc	243	30	service	service	NN
cord-003302-vxk7uqlc	243	31	'	'	''
cord-003302-vxk7uqlc	243	32	)	)	-RRB-
cord-003302-vxk7uqlc	243	33	has	have	VBZ
cord-003302-vxk7uqlc	243	34	withstood	withstand	VBN
cord-003302-vxk7uqlc	243	35	challenge	challenge	NN
cord-003302-vxk7uqlc	243	36	for	for	IN
cord-003302-vxk7uqlc	243	37	almost	almost	RB
cord-003302-vxk7uqlc	243	38	160	160	CD
cord-003302-vxk7uqlc	243	39	years	year	NNS
cord-003302-vxk7uqlc	243	40	.	.	.
cord-003302-vxk7uqlc	244	1	The	the	DT
cord-003302-vxk7uqlc	244	2	idea	idea	NN
cord-003302-vxk7uqlc	244	3	(	(	-LRB-
cord-003302-vxk7uqlc	244	4	hypothesis	hypothesis	NN
cord-003302-vxk7uqlc	244	5	)	)	-RRB-
cord-003302-vxk7uqlc	244	6	of	of	IN
cord-003302-vxk7uqlc	244	7	treating	treat	VBG
cord-003302-vxk7uqlc	244	8	the	the	DT
cord-003302-vxk7uqlc	244	9	host	host	NN
cord-003302-vxk7uqlc	244	10	response	response	NN
cord-003302-vxk7uqlc	244	11	to	to	IN
cord-003302-vxk7uqlc	244	12	pandemic	pandemic	NN
cord-003302-vxk7uqlc	244	13	influenza	influenza	NN
cord-003302-vxk7uqlc	244	14	was	be	VBD
cord-003302-vxk7uqlc	244	15	introduced	introduce	VBN
cord-003302-vxk7uqlc	244	16	in	in	IN
cord-003302-vxk7uqlc	244	17	2004	2004	CD
cord-003302-vxk7uqlc	244	18	[	[	-LRB-
cord-003302-vxk7uqlc	244	19	2	2	CD
cord-003302-vxk7uqlc	244	20	]	]	-RRB-
cord-003302-vxk7uqlc	244	21	.	.	.
cord-003302-vxk7uqlc	245	1	Its	-PRON-	PRP$
cord-003302-vxk7uqlc	245	2	potential	potential	JJ
cord-003302-vxk7uqlc	245	3	explanatory	explanatory	JJ
cord-003302-vxk7uqlc	245	4	power	power	NN
cord-003302-vxk7uqlc	245	5	has	have	VBZ
cord-003302-vxk7uqlc	245	6	also	also	RB
cord-003302-vxk7uqlc	245	7	been	be	VBN
cord-003302-vxk7uqlc	245	8	supported	support	VBN
cord-003302-vxk7uqlc	245	9	by	by	IN
cord-003302-vxk7uqlc	245	10	experimental	experimental	JJ
cord-003302-vxk7uqlc	245	11	and	and	CC
cord-003302-vxk7uqlc	245	12	clinical	clinical	JJ
cord-003302-vxk7uqlc	245	13	observations	observation	NNS
cord-003302-vxk7uqlc	245	14	,	,	,
cord-003302-vxk7uqlc	245	15	although	although	IN
cord-003302-vxk7uqlc	245	16	treating	treat	VBG
cord-003302-vxk7uqlc	245	17	the	the	DT
cord-003302-vxk7uqlc	245	18	host	host	NN
cord-003302-vxk7uqlc	245	19	response	response	NN
cord-003302-vxk7uqlc	245	20	has	have	VBZ
cord-003302-vxk7uqlc	245	21	received	receive	VBN
cord-003302-vxk7uqlc	245	22	little	little	JJ
cord-003302-vxk7uqlc	245	23	attention	attention	NN
cord-003302-vxk7uqlc	245	24	from	from	IN
cord-003302-vxk7uqlc	245	25	scientists	scientist	NNS
cord-003302-vxk7uqlc	245	26	and	and	CC
cord-003302-vxk7uqlc	245	27	health	health	NN
cord-003302-vxk7uqlc	245	28	officials	official	NNS
cord-003302-vxk7uqlc	245	29	[	[	-LRB-
cord-003302-vxk7uqlc	245	30	4	4	CD
cord-003302-vxk7uqlc	245	31	]	]	-RRB-
cord-003302-vxk7uqlc	245	32	[	[	-LRB-
cord-003302-vxk7uqlc	245	33	5	5	CD
cord-003302-vxk7uqlc	245	34	]	]	-RRB-
cord-003302-vxk7uqlc	245	35	[	[	-LRB-
cord-003302-vxk7uqlc	245	36	6	6	CD
cord-003302-vxk7uqlc	245	37	]	]	-RRB-
cord-003302-vxk7uqlc	245	38	[	[	-LRB-
cord-003302-vxk7uqlc	245	39	7	7	CD
cord-003302-vxk7uqlc	245	40	]	]	-RRB-
cord-003302-vxk7uqlc	245	41	[	[	-LRB-
cord-003302-vxk7uqlc	245	42	8	8	CD
cord-003302-vxk7uqlc	245	43	]	]	-RRB-
cord-003302-vxk7uqlc	245	44	[	[	-LRB-
cord-003302-vxk7uqlc	245	45	9	9	CD
cord-003302-vxk7uqlc	245	46	]	]	-RRB-
cord-003302-vxk7uqlc	245	47	.	.	.
cord-003302-vxk7uqlc	246	1	Yet	yet	CC
cord-003302-vxk7uqlc	246	2	in	in	IN
cord-003302-vxk7uqlc	246	3	a	a	DT
cord-003302-vxk7uqlc	246	4	practical	practical	JJ
cord-003302-vxk7uqlc	246	5	sense	sense	NN
cord-003302-vxk7uqlc	246	6	this	this	DT
cord-003302-vxk7uqlc	246	7	approach	approach	NN
cord-003302-vxk7uqlc	246	8	to	to	IN
cord-003302-vxk7uqlc	246	9	treatment	treatment	NN
cord-003302-vxk7uqlc	246	10	could	could	MD
cord-003302-vxk7uqlc	246	11	be	be	VB
cord-003302-vxk7uqlc	246	12	of	of	IN
cord-003302-vxk7uqlc	246	13	great	great	JJ
cord-003302-vxk7uqlc	246	14	service	service	NN
cord-003302-vxk7uqlc	246	15	(	(	-LRB-
cord-003302-vxk7uqlc	246	16	in	in	IN
cord-003302-vxk7uqlc	246	17	Darwin	Darwin	NNP
cord-003302-vxk7uqlc	246	18	's	's	POS
cord-003302-vxk7uqlc	246	19	word	word	NN
cord-003302-vxk7uqlc	246	20	)	)	-RRB-
cord-003302-vxk7uqlc	246	21	if	if	IN
cord-003302-vxk7uqlc	246	22	it	-PRON-	PRP
cord-003302-vxk7uqlc	246	23	could	could	MD
cord-003302-vxk7uqlc	246	24	reduce	reduce	VB
cord-003302-vxk7uqlc	246	25	global	global	JJ
cord-003302-vxk7uqlc	246	26	mortality	mortality	NN
cord-003302-vxk7uqlc	246	27	during	during	IN
cord-003302-vxk7uqlc	246	28	the	the	DT
cord-003302-vxk7uqlc	246	29	next	next	JJ
cord-003302-vxk7uqlc	246	30	pandemic	pandemic	NN
cord-003302-vxk7uqlc	246	31	.	.	.
cord-003302-vxk7uqlc	247	1	Kobzik	Kobzik	NNP
cord-003302-vxk7uqlc	247	2	and	and	CC
cord-003302-vxk7uqlc	247	3	colleagues	colleague	NNS
cord-003302-vxk7uqlc	247	4	have	have	VBP
cord-003302-vxk7uqlc	247	5	shown	show	VBN
cord-003302-vxk7uqlc	247	6	age	age	NN
cord-003302-vxk7uqlc	247	7	-	-	HYPH
cord-003302-vxk7uqlc	247	8	specific	specific	JJ
cord-003302-vxk7uqlc	247	9	differences	difference	NNS
cord-003302-vxk7uqlc	247	10	in	in	IN
cord-003302-vxk7uqlc	247	11	influenza	influenza	NN
cord-003302-vxk7uqlc	247	12	mortality	mortality	NN
cord-003302-vxk7uqlc	247	13	in	in	IN
cord-003302-vxk7uqlc	247	14	mice	mouse	NNS
cord-003302-vxk7uqlc	247	15	before	before	IN
cord-003302-vxk7uqlc	247	16	and	and	CC
cord-003302-vxk7uqlc	247	17	after	after	IN
cord-003302-vxk7uqlc	247	18	puberty	puberty	NN
cord-003302-vxk7uqlc	247	19	that	that	WDT
cord-003302-vxk7uqlc	247	20	are	be	VBP
cord-003302-vxk7uqlc	247	21	not	not	RB
cord-003302-vxk7uqlc	247	22	affected	affect	VBN
cord-003302-vxk7uqlc	247	23	by	by	IN
cord-003302-vxk7uqlc	247	24	previous	previous	JJ
cord-003302-vxk7uqlc	247	25	infection	infection	NN
cord-003302-vxk7uqlc	247	26	(	(	-LRB-
cord-003302-vxk7uqlc	247	27	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	247	28	imprinting	imprinting	NN
cord-003302-vxk7uqlc	247	29	)	)	-RRB-
cord-003302-vxk7uqlc	247	30	with	with	IN
cord-003302-vxk7uqlc	247	31	influenza	influenza	NN
cord-003302-vxk7uqlc	247	32	viruses	virus	NNS
cord-003302-vxk7uqlc	247	33	[	[	-LRB-
cord-003302-vxk7uqlc	247	34	26	26	CD
cord-003302-vxk7uqlc	247	35	]	]	-RRB-
cord-003302-vxk7uqlc	247	36	.	.	.
cord-003302-vxk7uqlc	248	1	Considered	consider	VBN
cord-003302-vxk7uqlc	248	2	with	with	IN
cord-003302-vxk7uqlc	248	3	evidence	evidence	NN
cord-003302-vxk7uqlc	248	4	from	from	IN
cord-003302-vxk7uqlc	248	5	endotoxemic	endotoxemic	NNP
cord-003302-vxk7uqlc	248	6	mice	mouse	NNS
cord-003302-vxk7uqlc	248	7	[	[	-LRB-
cord-003302-vxk7uqlc	248	8	28	28	CD
cord-003302-vxk7uqlc	248	9	]	]	-RRB-
cord-003302-vxk7uqlc	248	10	and	and	CC
cord-003302-vxk7uqlc	248	11	other	other	JJ
cord-003302-vxk7uqlc	248	12	studies	study	NNS
cord-003302-vxk7uqlc	248	13	[	[	-LRB-
cord-003302-vxk7uqlc	248	14	4	4	CD
cord-003302-vxk7uqlc	248	15	]	]	-RRB-
cord-003302-vxk7uqlc	248	16	[	[	-LRB-
cord-003302-vxk7uqlc	248	17	5	5	CD
cord-003302-vxk7uqlc	248	18	]	]	-RRB-
cord-003302-vxk7uqlc	248	19	[	[	-LRB-
cord-003302-vxk7uqlc	248	20	6	6	CD
cord-003302-vxk7uqlc	248	21	]	]	-RRB-
cord-003302-vxk7uqlc	248	22	[	[	-LRB-
cord-003302-vxk7uqlc	248	23	7	7	CD
cord-003302-vxk7uqlc	248	24	]	]	-RRB-
cord-003302-vxk7uqlc	248	25	[	[	-LRB-
cord-003302-vxk7uqlc	248	26	8	8	CD
cord-003302-vxk7uqlc	248	27	]	]	-RRB-
cord-003302-vxk7uqlc	248	28	[	[	-LRB-
cord-003302-vxk7uqlc	248	29	9	9	CD
cord-003302-vxk7uqlc	248	30	]	]	-RRB-
cord-003302-vxk7uqlc	248	31	,	,	,
cord-003302-vxk7uqlc	248	32	their	-PRON-	PRP$
cord-003302-vxk7uqlc	248	33	findings	finding	NNS
cord-003302-vxk7uqlc	248	34	suggest	suggest	VBP
cord-003302-vxk7uqlc	248	35	that	that	IN
cord-003302-vxk7uqlc	248	36	the	the	DT
cord-003302-vxk7uqlc	248	37	mortality	mortality	NN
cord-003302-vxk7uqlc	248	38	impact	impact	NN
cord-003302-vxk7uqlc	248	39	of	of	IN
cord-003302-vxk7uqlc	248	40	pandemic	pandemic	NN
cord-003302-vxk7uqlc	248	41	and	and	CC
cord-003302-vxk7uqlc	248	42	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	248	43	influenza	influenza	NN
cord-003302-vxk7uqlc	248	44	and	and	CC
cord-003302-vxk7uqlc	248	45	other	other	JJ
cord-003302-vxk7uqlc	248	46	forms	form	NNS
cord-003302-vxk7uqlc	248	47	of	of	IN
cord-003302-vxk7uqlc	248	48	acute	acute	JJ
cord-003302-vxk7uqlc	248	49	critical	critical	JJ
cord-003302-vxk7uqlc	248	50	illness	illness	NN
cord-003302-vxk7uqlc	248	51	might	may	MD
cord-003302-vxk7uqlc	248	52	be	be	VB
cord-003302-vxk7uqlc	248	53	reduced	reduce	VBN
cord-003302-vxk7uqlc	248	54	by	by	IN
cord-003302-vxk7uqlc	248	55	treating	treat	VBG
cord-003302-vxk7uqlc	248	56	the	the	DT
cord-003302-vxk7uqlc	248	57	host	host	NN
cord-003302-vxk7uqlc	248	58	response	response	NN
cord-003302-vxk7uqlc	248	59	.	.	.
cord-003302-vxk7uqlc	249	1	By	by	IN
cord-003302-vxk7uqlc	249	2	reducing	reduce	VBG
cord-003302-vxk7uqlc	249	3	the	the	DT
cord-003302-vxk7uqlc	249	4	damage	damage	NN
cord-003302-vxk7uqlc	249	5	caused	cause	VBN
cord-003302-vxk7uqlc	249	6	by	by	IN
cord-003302-vxk7uqlc	249	7	influenza	influenza	NN
cord-003302-vxk7uqlc	249	8	in	in	IN
cord-003302-vxk7uqlc	249	9	adults	adult	NNS
cord-003302-vxk7uqlc	249	10	to	to	IN
cord-003302-vxk7uqlc	249	11	the	the	DT
cord-003302-vxk7uqlc	249	12	more	more	RBR
cord-003302-vxk7uqlc	249	13	tolerant	tolerant	JJ
cord-003302-vxk7uqlc	249	14	response	response	NN
cord-003302-vxk7uqlc	249	15	seen	see	VBN
cord-003302-vxk7uqlc	249	16	in	in	IN
cord-003302-vxk7uqlc	249	17	children	child	NNS
cord-003302-vxk7uqlc	249	18	,	,	,
cord-003302-vxk7uqlc	249	19	treatment	treatment	NN
cord-003302-vxk7uqlc	249	20	could	could	MD
cord-003302-vxk7uqlc	249	21	in	in	IN
cord-003302-vxk7uqlc	249	22	effect	effect	NN
cord-003302-vxk7uqlc	249	23	"	"	``
cord-003302-vxk7uqlc	249	24	roll	roll	NN
cord-003302-vxk7uqlc	249	25	back	back	RB
cord-003302-vxk7uqlc	249	26	"	"	''
cord-003302-vxk7uqlc	249	27	evolution	evolution	NN
cord-003302-vxk7uqlc	249	28	.	.	.
cord-003302-vxk7uqlc	250	1	Physicians	physician	NNS
cord-003302-vxk7uqlc	250	2	will	will	MD
cord-003302-vxk7uqlc	250	3	inevitably	inevitably	RB
cord-003302-vxk7uqlc	250	4	be	be	VB
cord-003302-vxk7uqlc	250	5	called	call	VBN
cord-003302-vxk7uqlc	250	6	upon	upon	IN
cord-003302-vxk7uqlc	250	7	to	to	TO
cord-003302-vxk7uqlc	250	8	manage	manage	VB
cord-003302-vxk7uqlc	250	9	seriously	seriously	RB
cord-003302-vxk7uqlc	250	10	ill	ill	JJ
cord-003302-vxk7uqlc	250	11	patients	patient	NNS
cord-003302-vxk7uqlc	250	12	during	during	IN
cord-003302-vxk7uqlc	250	13	the	the	DT
cord-003302-vxk7uqlc	250	14	next	next	JJ
cord-003302-vxk7uqlc	250	15	pandemic	pandemic	NN
cord-003302-vxk7uqlc	250	16	,	,	,
cord-003302-vxk7uqlc	250	17	but	but	CC
cord-003302-vxk7uqlc	250	18	there	there	EX
cord-003302-vxk7uqlc	250	19	is	be	VBZ
cord-003302-vxk7uqlc	250	20	a	a	DT
cord-003302-vxk7uqlc	250	21	real	real	JJ
cord-003302-vxk7uqlc	250	22	risk	risk	NN
cord-003302-vxk7uqlc	250	23	they	-PRON-	PRP
cord-003302-vxk7uqlc	250	24	will	will	MD
cord-003302-vxk7uqlc	250	25	relive	relive	VB
cord-003302-vxk7uqlc	250	26	the	the	DT
cord-003302-vxk7uqlc	250	27	experiences	experience	NNS
cord-003302-vxk7uqlc	250	28	of	of	IN
cord-003302-vxk7uqlc	250	29	physicians	physician	NNS
cord-003302-vxk7uqlc	250	30	100	100	CD
cord-003302-vxk7uqlc	250	31	years	year	NNS
cord-003302-vxk7uqlc	250	32	ago	ago	RB
cord-003302-vxk7uqlc	250	33	[	[	-LRB-
cord-003302-vxk7uqlc	250	34	9	9	CD
cord-003302-vxk7uqlc	250	35	,	,	,
cord-003302-vxk7uqlc	250	36	86	86	CD
cord-003302-vxk7uqlc	250	37	]	]	-RRB-
cord-003302-vxk7uqlc	250	38	.	.	.
cord-003302-vxk7uqlc	251	1	This	this	DT
cord-003302-vxk7uqlc	251	2	is	be	VBZ
cord-003302-vxk7uqlc	251	3	sure	sure	JJ
cord-003302-vxk7uqlc	251	4	to	to	TO
cord-003302-vxk7uqlc	251	5	occur	occur	VB
cord-003302-vxk7uqlc	251	6	if	if	IN
cord-003302-vxk7uqlc	251	7	influenza	influenza	NN
cord-003302-vxk7uqlc	251	8	scientists	scientist	NNS
cord-003302-vxk7uqlc	251	9	and	and	CC
cord-003302-vxk7uqlc	251	10	public	public	JJ
cord-003302-vxk7uqlc	251	11	health	health	NN
cord-003302-vxk7uqlc	251	12	officials	official	NNS
cord-003302-vxk7uqlc	251	13	continue	continue	VBP
cord-003302-vxk7uqlc	251	14	to	to	TO
cord-003302-vxk7uqlc	251	15	reject	reject	VB
cord-003302-vxk7uqlc	251	16	the	the	DT
cord-003302-vxk7uqlc	251	17	possibility	possibility	NN
cord-003302-vxk7uqlc	251	18	that	that	IN
cord-003302-vxk7uqlc	251	19	host	host	NN
cord-003302-vxk7uqlc	251	20	response	response	NN
cord-003302-vxk7uqlc	251	21	treatment	treatment	NN
cord-003302-vxk7uqlc	251	22	could	could	MD
cord-003302-vxk7uqlc	251	23	reduce	reduce	VB
cord-003302-vxk7uqlc	251	24	pandemic	pandemic	NN
cord-003302-vxk7uqlc	251	25	mortality	mortality	NN
cord-003302-vxk7uqlc	251	26	[	[	-LRB-
cord-003302-vxk7uqlc	251	27	7	7	CD
cord-003302-vxk7uqlc	251	28	]	]	-RRB-
cord-003302-vxk7uqlc	251	29	[	[	-LRB-
cord-003302-vxk7uqlc	251	30	8	8	CD
cord-003302-vxk7uqlc	251	31	]	]	-RRB-
cord-003302-vxk7uqlc	251	32	[	[	-LRB-
cord-003302-vxk7uqlc	251	33	9	9	CD
cord-003302-vxk7uqlc	251	34	]	]	-RRB-
cord-003302-vxk7uqlc	251	35	87	87	CD
cord-003302-vxk7uqlc	251	36	]	]	-RRB-
cord-003302-vxk7uqlc	251	37	.	.	.
cord-003302-vxk7uqlc	252	1	If	if	IN
cord-003302-vxk7uqlc	252	2	we	-PRON-	PRP
cord-003302-vxk7uqlc	252	3	are	be	VBP
cord-003302-vxk7uqlc	252	4	to	to	TO
cord-003302-vxk7uqlc	252	5	take	take	VB
cord-003302-vxk7uqlc	252	6	seriously	seriously	RB
cord-003302-vxk7uqlc	252	7	the	the	DT
cord-003302-vxk7uqlc	252	8	challenge	challenge	NN
cord-003302-vxk7uqlc	252	9	of	of	IN
cord-003302-vxk7uqlc	252	10	preparing	prepare	VBG
cord-003302-vxk7uqlc	252	11	for	for	IN
cord-003302-vxk7uqlc	252	12	the	the	DT
cord-003302-vxk7uqlc	252	13	next	next	JJ
cord-003302-vxk7uqlc	252	14	pandemic	pandemic	NN
cord-003302-vxk7uqlc	252	15	,	,	,
cord-003302-vxk7uqlc	252	16	it	-PRON-	PRP
cord-003302-vxk7uqlc	252	17	is	be	VBZ
cord-003302-vxk7uqlc	252	18	self	self	NN
cord-003302-vxk7uqlc	252	19	-	-	HYPH
cord-003302-vxk7uqlc	252	20	evident	evident	JJ
cord-003302-vxk7uqlc	252	21	that	that	IN
cord-003302-vxk7uqlc	252	22	a	a	DT
cord-003302-vxk7uqlc	252	23	"	"	``
cord-003302-vxk7uqlc	252	24	top	top	JJ
cord-003302-vxk7uqlc	252	25	down	down	RB
cord-003302-vxk7uqlc	252	26	"	"	''
cord-003302-vxk7uqlc	252	27	approach	approach	NN
cord-003302-vxk7uqlc	252	28	based	base	VBN
cord-003302-vxk7uqlc	252	29	on	on	IN
cord-003302-vxk7uqlc	252	30	vaccination	vaccination	NN
cord-003302-vxk7uqlc	252	31	and	and	CC
cord-003302-vxk7uqlc	252	32	antiviral	antiviral	JJ
cord-003302-vxk7uqlc	252	33	treatment	treatment	NN
cord-003302-vxk7uqlc	252	34	,	,	,
cord-003302-vxk7uqlc	252	35	driven	drive	VBN
cord-003302-vxk7uqlc	252	36	by	by	IN
cord-003302-vxk7uqlc	252	37	the	the	DT
cord-003302-vxk7uqlc	252	38	decisions	decision	NNS
cord-003302-vxk7uqlc	252	39	of	of	IN
cord-003302-vxk7uqlc	252	40	elite	elite	JJ
cord-003302-vxk7uqlc	252	41	scientists	scientist	NNS
cord-003302-vxk7uqlc	252	42	,	,	,
cord-003302-vxk7uqlc	252	43	health	health	NN
cord-003302-vxk7uqlc	252	44	officials	official	NNS
cord-003302-vxk7uqlc	252	45	and	and	CC
cord-003302-vxk7uqlc	252	46	corporate	corporate	JJ
cord-003302-vxk7uqlc	252	47	executives	executive	NNS
cord-003302-vxk7uqlc	252	48	,	,	,
cord-003302-vxk7uqlc	252	49	will	will	MD
cord-003302-vxk7uqlc	252	50	not	not	RB
cord-003302-vxk7uqlc	252	51	meet	meet	VB
cord-003302-vxk7uqlc	252	52	the	the	DT
cord-003302-vxk7uqlc	252	53	world	world	NN
cord-003302-vxk7uqlc	252	54	's	's	POS
cord-003302-vxk7uqlc	252	55	needs	need	NNS
cord-003302-vxk7uqlc	252	56	[	[	-LRB-
cord-003302-vxk7uqlc	252	57	2	2	CD
cord-003302-vxk7uqlc	252	58	]	]	-RRB-
cord-003302-vxk7uqlc	253	1	[	[	-LRB-
cord-003302-vxk7uqlc	253	2	3	3	CD
cord-003302-vxk7uqlc	253	3	]	]	-RRB-
cord-003302-vxk7uqlc	253	4	[	[	-LRB-
cord-003302-vxk7uqlc	253	5	4	4	CD
cord-003302-vxk7uqlc	253	6	]	]	-RRB-
cord-003302-vxk7uqlc	253	7	[	[	-LRB-
cord-003302-vxk7uqlc	253	8	5	5	CD
cord-003302-vxk7uqlc	253	9	]	]	-RRB-
cord-003302-vxk7uqlc	253	10	[	[	-LRB-
cord-003302-vxk7uqlc	253	11	6	6	CD
cord-003302-vxk7uqlc	253	12	]	]	-RRB-
cord-003302-vxk7uqlc	253	13	[	[	-LRB-
cord-003302-vxk7uqlc	253	14	7	7	CD
cord-003302-vxk7uqlc	253	15	]	]	-RRB-
cord-003302-vxk7uqlc	254	1	[	[	-LRB-
cord-003302-vxk7uqlc	254	2	8	8	CD
cord-003302-vxk7uqlc	254	3	]	]	-RRB-
cord-003302-vxk7uqlc	254	4	[	[	-LRB-
cord-003302-vxk7uqlc	254	5	9	9	CD
cord-003302-vxk7uqlc	254	6	]	]	-RRB-
cord-003302-vxk7uqlc	254	7	.	.	.
cord-003302-vxk7uqlc	255	1	Instead	instead	RB
cord-003302-vxk7uqlc	255	2	,	,	,
cord-003302-vxk7uqlc	255	3	an	an	DT
cord-003302-vxk7uqlc	255	4	effective	effective	JJ
cord-003302-vxk7uqlc	255	5	response	response	NN
cord-003302-vxk7uqlc	255	6	must	must	MD
cord-003302-vxk7uqlc	255	7	include	include	VB
cord-003302-vxk7uqlc	255	8	a	a	DT
cord-003302-vxk7uqlc	255	9	"	"	``
cord-003302-vxk7uqlc	255	10	bottom	bottom	NN
cord-003302-vxk7uqlc	255	11	up	up	RP
cord-003302-vxk7uqlc	255	12	"	"	''
cord-003302-vxk7uqlc	255	13	approach	approach	NN
cord-003302-vxk7uqlc	255	14	to	to	IN
cord-003302-vxk7uqlc	255	15	individual	individual	JJ
cord-003302-vxk7uqlc	255	16	patient	patient	JJ
cord-003302-vxk7uqlc	255	17	treatment	treatment	NN
cord-003302-vxk7uqlc	255	18	by	by	IN
cord-003302-vxk7uqlc	255	19	ordinary	ordinary	JJ
cord-003302-vxk7uqlc	255	20	doctors	doctor	NNS
cord-003302-vxk7uqlc	255	21	working	work	VBG
cord-003302-vxk7uqlc	255	22	in	in	IN
cord-003302-vxk7uqlc	255	23	ordinary	ordinary	JJ
cord-003302-vxk7uqlc	255	24	healthcare	healthcare	NN
cord-003302-vxk7uqlc	255	25	systems	system	NNS
cord-003302-vxk7uqlc	255	26	who	who	WP
cord-003302-vxk7uqlc	255	27	use	use	VBP
cord-003302-vxk7uqlc	255	28	ordinary	ordinary	JJ
cord-003302-vxk7uqlc	255	29	,	,	,
cord-003302-vxk7uqlc	255	30	widely	widely	RB
cord-003302-vxk7uqlc	255	31	available	available	JJ
cord-003302-vxk7uqlc	255	32	and	and	CC
cord-003302-vxk7uqlc	255	33	inexpensive	inexpensive	JJ
cord-003302-vxk7uqlc	255	34	generic	generic	JJ
cord-003302-vxk7uqlc	255	35	drugs	drug	NNS
cord-003302-vxk7uqlc	255	36	that	that	WDT
cord-003302-vxk7uqlc	255	37	modify	modify	VBP
cord-003302-vxk7uqlc	255	38	the	the	DT
cord-003302-vxk7uqlc	255	39	host	host	NN
cord-003302-vxk7uqlc	255	40	response	response	NN
cord-003302-vxk7uqlc	255	41	.	.	.
cord-003302-vxk7uqlc	256	1	The	the	DT
cord-003302-vxk7uqlc	256	2	studies	study	NNS
cord-003302-vxk7uqlc	256	3	reviewed	review	VBN
cord-003302-vxk7uqlc	256	4	here	here	RB
cord-003302-vxk7uqlc	256	5	suggest	suggest	VBP
cord-003302-vxk7uqlc	256	6	that	that	IN
cord-003302-vxk7uqlc	256	7	the	the	DT
cord-003302-vxk7uqlc	256	8	biological	biological	JJ
cord-003302-vxk7uqlc	256	9	basis	basis	NN
cord-003302-vxk7uqlc	256	10	for	for	IN
cord-003302-vxk7uqlc	256	11	treating	treat	VBG
cord-003302-vxk7uqlc	256	12	the	the	DT
cord-003302-vxk7uqlc	256	13	host	host	NN
cord-003302-vxk7uqlc	256	14	response	response	NN
cord-003302-vxk7uqlc	256	15	reflects	reflect	VBZ
cord-003302-vxk7uqlc	256	16	our	-PRON-	PRP$
cord-003302-vxk7uqlc	256	17	evolutionary	evolutionary	JJ
cord-003302-vxk7uqlc	256	18	heritage	heritage	NN
cord-003302-vxk7uqlc	256	19	.	.	.
cord-003302-vxk7uqlc	257	1	This	this	DT
cord-003302-vxk7uqlc	257	2	idea	idea	NN
cord-003302-vxk7uqlc	257	3	might	may	MD
cord-003302-vxk7uqlc	257	4	not	not	RB
cord-003302-vxk7uqlc	257	5	be	be	VB
cord-003302-vxk7uqlc	257	6	revolutionary	revolutionary	JJ
cord-003302-vxk7uqlc	257	7	[	[	-LRB-
cord-003302-vxk7uqlc	257	8	88	88	CD
cord-003302-vxk7uqlc	257	9	]	]	-RRB-
cord-003302-vxk7uqlc	257	10	,	,	,
cord-003302-vxk7uqlc	257	11	but	but	CC
cord-003302-vxk7uqlc	257	12	its	-PRON-	PRP$
cord-003302-vxk7uqlc	257	13	practical	practical	JJ
cord-003302-vxk7uqlc	257	14	implications	implication	NNS
cord-003302-vxk7uqlc	257	15	for	for	IN
cord-003302-vxk7uqlc	257	16	health	health	NN
cord-003302-vxk7uqlc	257	17	,	,	,
cord-003302-vxk7uqlc	257	18	equity	equity	NN
cord-003302-vxk7uqlc	257	19	and	and	CC
cord-003302-vxk7uqlc	257	20	security	security	NN
cord-003302-vxk7uqlc	257	21	during	during	IN
cord-003302-vxk7uqlc	257	22	the	the	DT
cord-003302-vxk7uqlc	257	23	next	next	JJ
cord-003302-vxk7uqlc	257	24	pandemic	pandemic	NN
cord-003302-vxk7uqlc	257	25	could	could	MD
cord-003302-vxk7uqlc	257	26	be	be	VB
cord-003302-vxk7uqlc	257	27	immense	immense	JJ
cord-003302-vxk7uqlc	257	28	.	.	.
cord-003302-vxk7uqlc	258	1	Consequently	consequently	RB
cord-003302-vxk7uqlc	258	2	,	,	,
cord-003302-vxk7uqlc	258	3	investigators	investigator	NNS
cord-003302-vxk7uqlc	258	4	must	must	MD
cord-003302-vxk7uqlc	258	5	undertake	undertake	VB
cord-003302-vxk7uqlc	258	6	laboratory	laboratory	NN
cord-003302-vxk7uqlc	258	7	and	and	CC
cord-003302-vxk7uqlc	258	8	clinical	clinical	JJ
cord-003302-vxk7uqlc	258	9	research	research	NN
cord-003302-vxk7uqlc	258	10	to	to	TO
cord-003302-vxk7uqlc	258	11	convincingly	convincingly	RB
cord-003302-vxk7uqlc	258	12	show	show	VB
cord-003302-vxk7uqlc	258	13	whether	whether	IN
cord-003302-vxk7uqlc	258	14	it	-PRON-	PRP
cord-003302-vxk7uqlc	258	15	will	will	MD
cord-003302-vxk7uqlc	258	16	be	be	VB
cord-003302-vxk7uqlc	258	17	effective	effective	JJ
cord-003302-vxk7uqlc	258	18	.	.	.
cord-003302-vxk7uqlc	259	1	If	if	IN
cord-003302-vxk7uqlc	259	2	it	-PRON-	PRP
cord-003302-vxk7uqlc	259	3	is	be	VBZ
cord-003302-vxk7uqlc	259	4	effective	effective	JJ
cord-003302-vxk7uqlc	259	5	and	and	CC
cord-003302-vxk7uqlc	259	6	is	be	VBZ
cord-003302-vxk7uqlc	259	7	put	put	VBN
cord-003302-vxk7uqlc	259	8	into	into	IN
cord-003302-vxk7uqlc	259	9	practice	practice	NN
cord-003302-vxk7uqlc	259	10	,	,	,
cord-003302-vxk7uqlc	259	11	it	-PRON-	PRP
cord-003302-vxk7uqlc	259	12	would	would	MD
cord-003302-vxk7uqlc	259	13	represent	represent	VB
cord-003302-vxk7uqlc	259	14	a	a	DT
cord-003302-vxk7uqlc	259	15	striking	striking	JJ
cord-003302-vxk7uqlc	259	16	application	application	NN
cord-003302-vxk7uqlc	259	17	of	of	IN
cord-003302-vxk7uqlc	259	18	the	the	DT
cord-003302-vxk7uqlc	259	19	idea	idea	NN
cord-003302-vxk7uqlc	259	20	of	of	IN
cord-003302-vxk7uqlc	259	21	evolutionary	evolutionary	JJ
cord-003302-vxk7uqlc	259	22	public	public	JJ
cord-003302-vxk7uqlc	259	23	health	health	NN
cord-003302-vxk7uqlc	259	24	[	[	-LRB-
cord-003302-vxk7uqlc	259	25	1	1	CD
cord-003302-vxk7uqlc	259	26	]	]	-RRB-
cord-003302-vxk7uqlc	259	27	.	.	.
cord-003302-vxk7uqlc	260	1	Conflict	conflict	NN
cord-003302-vxk7uqlc	260	2	of	of	IN
cord-003302-vxk7uqlc	260	3	interest	interest	NN
cord-003302-vxk7uqlc	260	4	:	:	:
cord-003302-vxk7uqlc	260	5	None	none	NN
cord-003302-vxk7uqlc	260	6	declared	declare	VBD
cord-003302-vxk7uqlc	260	7	.	.	.
cord-003302-vxk7uqlc	260	8	 	 	_SP
cord-003302-vxk7uqlc	261	1	Evolutionary	evolutionary	JJ
cord-003302-vxk7uqlc	261	2	public	public	JJ
cord-003302-vxk7uqlc	261	3	health	health	NN
cord-003302-vxk7uqlc	261	4	:	:	:
cord-003302-vxk7uqlc	261	5	introducing	introduce	VBG
cord-003302-vxk7uqlc	261	6	the	the	DT
cord-003302-vxk7uqlc	261	7	concept	concept	NN
cord-003302-vxk7uqlc	261	8	Pandemic	Pandemic	NNP
cord-003302-vxk7uqlc	261	9	influenza	influenza	NN
cord-003302-vxk7uqlc	261	10	:	:	:
cord-003302-vxk7uqlc	261	11	a	a	DT
cord-003302-vxk7uqlc	261	12	potential	potential	JJ
cord-003302-vxk7uqlc	261	13	role	role	NN
cord-003302-vxk7uqlc	261	14	for	for	IN
cord-003302-vxk7uqlc	261	15	statins	statin	NNS
cord-003302-vxk7uqlc	261	16	in	in	IN
cord-003302-vxk7uqlc	261	17	treatment	treatment	NN
cord-003302-vxk7uqlc	261	18	and	and	CC
cord-003302-vxk7uqlc	261	19	prophylaxis	prophylaxis	NN
cord-003302-vxk7uqlc	261	20	Commentary	commentary	NN
cord-003302-vxk7uqlc	261	21	:	:	:
cord-003302-vxk7uqlc	262	1	From	from	IN
cord-003302-vxk7uqlc	262	2	scarcity	scarcity	NN
cord-003302-vxk7uqlc	262	3	to	to	IN
cord-003302-vxk7uqlc	262	4	abundance	abundance	NN
cord-003302-vxk7uqlc	262	5	:	:	:
cord-003302-vxk7uqlc	262	6	pandemic	pandemic	JJ
cord-003302-vxk7uqlc	262	7	vaccines	vaccine	NNS
cord-003302-vxk7uqlc	262	8	and	and	CC
cord-003302-vxk7uqlc	262	9	other	other	JJ
cord-003302-vxk7uqlc	262	10	agents	agent	NNS
cord-003302-vxk7uqlc	262	11	for	for	IN
cord-003302-vxk7uqlc	262	12	"	"	``
cord-003302-vxk7uqlc	262	13	have	have	VBP
cord-003302-vxk7uqlc	262	14	not	not	RB
cord-003302-vxk7uqlc	262	15	"	"	``
cord-003302-vxk7uqlc	262	16	countries	country	NNS
cord-003302-vxk7uqlc	262	17	Meeting	meet	VBG
cord-003302-vxk7uqlc	262	18	the	the	DT
cord-003302-vxk7uqlc	262	19	challenge	challenge	NN
cord-003302-vxk7uqlc	262	20	of	of	IN
cord-003302-vxk7uqlc	262	21	influenza	influenza	NN
cord-003302-vxk7uqlc	262	22	pandemic	pandemic	JJ
cord-003302-vxk7uqlc	262	23	preparedness	preparedness	NN
cord-003302-vxk7uqlc	262	24	in	in	IN
cord-003302-vxk7uqlc	262	25	developing	develop	VBG
cord-003302-vxk7uqlc	262	26	countries	country	NNS
cord-003302-vxk7uqlc	262	27	Confronting	confront	VBG
cord-003302-vxk7uqlc	262	28	the	the	DT
cord-003302-vxk7uqlc	262	29	next	next	JJ
cord-003302-vxk7uqlc	262	30	influenza	influenza	NN
cord-003302-vxk7uqlc	262	31	pandemic	pandemic	NN
cord-003302-vxk7uqlc	262	32	with	with	IN
cord-003302-vxk7uqlc	262	33	antiinflammatory	antiinflammatory	JJ
cord-003302-vxk7uqlc	262	34	and	and	CC
cord-003302-vxk7uqlc	262	35	immunomodulatory	immunomodulatory	JJ
cord-003302-vxk7uqlc	262	36	agents	agent	NNS
cord-003302-vxk7uqlc	262	37	:	:	:
cord-003302-vxk7uqlc	262	38	why	why	WRB
cord-003302-vxk7uqlc	262	39	they	-PRON-	PRP
cord-003302-vxk7uqlc	262	40	are	be	VBP
cord-003302-vxk7uqlc	262	41	needed	need	VBN
cord-003302-vxk7uqlc	262	42	and	and	CC
cord-003302-vxk7uqlc	262	43	how	how	WRB
cord-003302-vxk7uqlc	262	44	they	-PRON-	PRP
cord-003302-vxk7uqlc	262	45	might	may	MD
cord-003302-vxk7uqlc	262	46	work	work	VB
cord-003302-vxk7uqlc	262	47	Treating	treat	VBG
cord-003302-vxk7uqlc	262	48	influenza	influenza	NN
cord-003302-vxk7uqlc	262	49	with	with	IN
cord-003302-vxk7uqlc	262	50	statins	statin	NNS
cord-003302-vxk7uqlc	262	51	and	and	CC
cord-003302-vxk7uqlc	262	52	other	other	JJ
cord-003302-vxk7uqlc	262	53	immunomodulatory	immunomodulatory	JJ
cord-003302-vxk7uqlc	262	54	agents	agent	NNS
cord-003302-vxk7uqlc	263	1	How	how	WRB
cord-003302-vxk7uqlc	263	2	will	will	MD
cord-003302-vxk7uqlc	263	3	physicians	physician	NNS
cord-003302-vxk7uqlc	263	4	respond	respond	VB
cord-003302-vxk7uqlc	263	5	to	to	IN
cord-003302-vxk7uqlc	263	6	the	the	DT
cord-003302-vxk7uqlc	263	7	next	next	JJ
cord-003302-vxk7uqlc	263	8	influenza	influenza	NN
cord-003302-vxk7uqlc	263	9	pandemic	pandemic	NN
cord-003302-vxk7uqlc	263	10	Treating	treat	VBG
cord-003302-vxk7uqlc	263	11	the	the	DT
cord-003302-vxk7uqlc	263	12	host	host	NN
cord-003302-vxk7uqlc	263	13	response	response	NN
cord-003302-vxk7uqlc	263	14	to	to	IN
cord-003302-vxk7uqlc	263	15	emerging	emerge	VBG
cord-003302-vxk7uqlc	263	16	virus	virus	NN
cord-003302-vxk7uqlc	263	17	diseases	disease	NNS
cord-003302-vxk7uqlc	263	18	:	:	:
cord-003302-vxk7uqlc	264	1	lessons	lesson	NNS
cord-003302-vxk7uqlc	264	2	learned	learn	VBN
cord-003302-vxk7uqlc	264	3	from	from	IN
cord-003302-vxk7uqlc	264	4	sepsis	sepsis	NN
cord-003302-vxk7uqlc	264	5	,	,	,
cord-003302-vxk7uqlc	264	6	pneumonia	pneumonia	NN
cord-003302-vxk7uqlc	264	7	,	,	,
cord-003302-vxk7uqlc	264	8	influenza	influenza	NN
cord-003302-vxk7uqlc	264	9	and	and	CC
cord-003302-vxk7uqlc	264	10	Ebola	Ebola	NNP
cord-003302-vxk7uqlc	264	11	Clinician	clinician	NN
cord-003302-vxk7uqlc	264	12	-	-	HYPH
cord-003302-vxk7uqlc	264	13	initiated	initiate	VBN
cord-003302-vxk7uqlc	264	14	research	research	NN
cord-003302-vxk7uqlc	264	15	on	on	IN
cord-003302-vxk7uqlc	264	16	treating	treat	VBG
cord-003302-vxk7uqlc	264	17	the	the	DT
cord-003302-vxk7uqlc	264	18	host	host	NN
cord-003302-vxk7uqlc	264	19	response	response	NN
cord-003302-vxk7uqlc	264	20	to	to	IN
cord-003302-vxk7uqlc	264	21	pandemic	pandemic	NN
cord-003302-vxk7uqlc	264	22	influenza	influenza	NN
cord-003302-vxk7uqlc	264	23	Protective	protective	JJ
cord-003302-vxk7uqlc	264	24	immunity	immunity	NN
cord-003302-vxk7uqlc	264	25	and	and	CC
cord-003302-vxk7uqlc	264	26	susceptibility	susceptibility	NN
cord-003302-vxk7uqlc	264	27	to	to	IN
cord-003302-vxk7uqlc	264	28	infectious	infectious	JJ
cord-003302-vxk7uqlc	264	29	diseases	disease	NNS
cord-003302-vxk7uqlc	264	30	:	:	:
cord-003302-vxk7uqlc	264	31	lessons	lesson	NNS
cord-003302-vxk7uqlc	264	32	from	from	IN
cord-003302-vxk7uqlc	264	33	the	the	DT
cord-003302-vxk7uqlc	264	34	1918	1918	CD
cord-003302-vxk7uqlc	264	35	influenza	influenza	NN
cord-003302-vxk7uqlc	264	36	pandemic	pandemic	NN
cord-003302-vxk7uqlc	264	37	Predominant	predominant	JJ
cord-003302-vxk7uqlc	264	38	role	role	NN
cord-003302-vxk7uqlc	264	39	of	of	IN
cord-003302-vxk7uqlc	264	40	bacterial	bacterial	JJ
cord-003302-vxk7uqlc	264	41	pneumonia	pneumonia	NN
cord-003302-vxk7uqlc	264	42	as	as	IN
cord-003302-vxk7uqlc	264	43	a	a	DT
cord-003302-vxk7uqlc	264	44	cause	cause	NN
cord-003302-vxk7uqlc	264	45	of	of	IN
cord-003302-vxk7uqlc	264	46	death	death	NN
cord-003302-vxk7uqlc	264	47	in	in	IN
cord-003302-vxk7uqlc	264	48	pandemic	pandemic	NN
cord-003302-vxk7uqlc	264	49	influenza	influenza	NN
cord-003302-vxk7uqlc	264	50	:	:	:
cord-003302-vxk7uqlc	264	51	implications	implication	NNS
cord-003302-vxk7uqlc	264	52	for	for	IN
cord-003302-vxk7uqlc	264	53	pandemic	pandemic	NN
cord-003302-vxk7uqlc	264	54	influenza	influenza	NN
cord-003302-vxk7uqlc	264	55	preparedness	preparedness	NN
cord-003302-vxk7uqlc	264	56	Was	be	VBD
cord-003302-vxk7uqlc	264	57	bacterial	bacterial	JJ
cord-003302-vxk7uqlc	264	58	pneumonia	pneumonia	NN
cord-003302-vxk7uqlc	265	1	the	the	DT
cord-003302-vxk7uqlc	265	2	predominant	predominant	JJ
cord-003302-vxk7uqlc	265	3	cause	cause	NN
cord-003302-vxk7uqlc	265	4	of	of	IN
cord-003302-vxk7uqlc	265	5	death	death	NN
cord-003302-vxk7uqlc	265	6	in	in	IN
cord-003302-vxk7uqlc	265	7	the	the	DT
cord-003302-vxk7uqlc	265	8	1918	1918	CD
cord-003302-vxk7uqlc	265	9	-	-	SYM
cord-003302-vxk7uqlc	265	10	1919	1919	CD
cord-003302-vxk7uqlc	265	11	influenza	influenza	NN
cord-003302-vxk7uqlc	265	12	pandemic	pandemic	NN
cord-003302-vxk7uqlc	265	13	?	?	.
cord-003302-vxk7uqlc	266	1	Molecular	molecular	JJ
cord-003302-vxk7uqlc	266	2	epidemiology	epidemiology	NN
cord-003302-vxk7uqlc	266	3	of	of	IN
cord-003302-vxk7uqlc	266	4	A	a	NN
cord-003302-vxk7uqlc	266	5	/	/	SYM
cord-003302-vxk7uqlc	266	6	H3N2	H3N2	NNP
cord-003302-vxk7uqlc	266	7	and	and	CC
cord-003302-vxk7uqlc	266	8	A	A	NNP
cord-003302-vxk7uqlc	266	9	/	/	SYM
cord-003302-vxk7uqlc	266	10	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	266	11	influenza	influenza	NN
cord-003302-vxk7uqlc	266	12	virus	virus	NN
cord-003302-vxk7uqlc	266	13	during	during	IN
cord-003302-vxk7uqlc	266	14	a	a	DT
cord-003302-vxk7uqlc	266	15	single	single	JJ
cord-003302-vxk7uqlc	266	16	epidemic	epidemic	NN
cord-003302-vxk7uqlc	266	17	season	season	NN
cord-003302-vxk7uqlc	266	18	in	in	IN
cord-003302-vxk7uqlc	266	19	the	the	DT
cord-003302-vxk7uqlc	266	20	United	United	NNP
cord-003302-vxk7uqlc	266	21	States	States	NNP
cord-003302-vxk7uqlc	267	1	Geography	geography	NN
cord-003302-vxk7uqlc	267	2	may	may	MD
cord-003302-vxk7uqlc	267	3	explain	explain	VB
cord-003302-vxk7uqlc	267	4	adult	adult	NN
cord-003302-vxk7uqlc	267	5	mortality	mortality	NN
cord-003302-vxk7uqlc	267	6	from	from	IN
cord-003302-vxk7uqlc	267	7	the	the	DT
cord-003302-vxk7uqlc	267	8	1918	1918	CD
cord-003302-vxk7uqlc	267	9	-	-	SYM
cord-003302-vxk7uqlc	267	10	20	20	CD
cord-003302-vxk7uqlc	267	11	influenza	influenza	NN
cord-003302-vxk7uqlc	267	12	pandemic	pandemic	NN
cord-003302-vxk7uqlc	267	13	The	the	DT
cord-003302-vxk7uqlc	267	14	doctrine	doctrine	NN
cord-003302-vxk7uqlc	267	15	of	of	IN
cord-003302-vxk7uqlc	267	16	original	original	JJ
cord-003302-vxk7uqlc	267	17	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	267	18	sin	sin	NN
cord-003302-vxk7uqlc	267	19	:	:	:
cord-003302-vxk7uqlc	267	20	separating	separate	VBG
cord-003302-vxk7uqlc	267	21	good	good	RB
cord-003302-vxk7uqlc	267	22	from	from	IN
cord-003302-vxk7uqlc	267	23	evil	evil	JJ
cord-003302-vxk7uqlc	267	24	Vaccine	vaccine	NN
cord-003302-vxk7uqlc	267	25	-	-	HYPH
cord-003302-vxk7uqlc	267	26	induced	induce	VBN
cord-003302-vxk7uqlc	267	27	antibodies	antibody	NNS
cord-003302-vxk7uqlc	267	28	that	that	WDT
cord-003302-vxk7uqlc	267	29	neutralize	neutralize	VBP
cord-003302-vxk7uqlc	267	30	group	group	NN
cord-003302-vxk7uqlc	267	31	1	1	CD
cord-003302-vxk7uqlc	267	32	and	and	CC
cord-003302-vxk7uqlc	267	33	group	group	NN
cord-003302-vxk7uqlc	268	1	2	2	LS
cord-003302-vxk7uqlc	268	2	influenza	influenza	NN
cord-003302-vxk7uqlc	268	3	A	a	DT
cord-003302-vxk7uqlc	268	4	viruses	virus	NNS
cord-003302-vxk7uqlc	269	1	Age	age	NN
cord-003302-vxk7uqlc	269	2	-	-	HYPH
cord-003302-vxk7uqlc	269	3	and	and	CC
cord-003302-vxk7uqlc	269	4	sex	sex	NN
cord-003302-vxk7uqlc	269	5	-	-	HYPH
cord-003302-vxk7uqlc	269	6	specific	specific	JJ
cord-003302-vxk7uqlc	269	7	mortality	mortality	NN
cord-003302-vxk7uqlc	269	8	associated	associate	VBN
cord-003302-vxk7uqlc	269	9	with	with	IN
cord-003302-vxk7uqlc	269	10	the	the	DT
cord-003302-vxk7uqlc	269	11	1918	1918	CD
cord-003302-vxk7uqlc	269	12	-	-	SYM
cord-003302-vxk7uqlc	269	13	1919	1919	CD
cord-003302-vxk7uqlc	269	14	influenza	influenza	NN
cord-003302-vxk7uqlc	269	15	pandemic	pandemic	NN
cord-003302-vxk7uqlc	269	16	in	in	IN
cord-003302-vxk7uqlc	269	17	Kentucky	Kentucky	NNP
cord-003302-vxk7uqlc	269	18	Age	Age	NNP
cord-003302-vxk7uqlc	269	19	-	-	HYPH
cord-003302-vxk7uqlc	269	20	specific	specific	JJ
cord-003302-vxk7uqlc	269	21	mortality	mortality	NN
cord-003302-vxk7uqlc	269	22	during	during	IN
cord-003302-vxk7uqlc	269	23	the	the	DT
cord-003302-vxk7uqlc	269	24	1918	1918	CD
cord-003302-vxk7uqlc	269	25	influenza	influenza	NN
cord-003302-vxk7uqlc	269	26	pandemic	pandemic	NN
cord-003302-vxk7uqlc	269	27	:	:	:
cord-003302-vxk7uqlc	269	28	unravelling	unravel	VBG
cord-003302-vxk7uqlc	269	29	the	the	DT
cord-003302-vxk7uqlc	269	30	mystery	mystery	NN
cord-003302-vxk7uqlc	269	31	of	of	IN
cord-003302-vxk7uqlc	269	32	high	high	JJ
cord-003302-vxk7uqlc	269	33	young	young	JJ
cord-003302-vxk7uqlc	269	34	adult	adult	NN
cord-003302-vxk7uqlc	269	35	mortality	mortality	NN
cord-003302-vxk7uqlc	269	36	Genesis	Genesis	NNP
cord-003302-vxk7uqlc	269	37	and	and	CC
cord-003302-vxk7uqlc	269	38	pathogenesis	pathogenesis	NN
cord-003302-vxk7uqlc	269	39	of	of	IN
cord-003302-vxk7uqlc	269	40	the	the	DT
cord-003302-vxk7uqlc	269	41	1918	1918	CD
cord-003302-vxk7uqlc	269	42	pandemic	pandemic	NN
cord-003302-vxk7uqlc	269	43	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	269	44	influenza	influenza	NN
cord-003302-vxk7uqlc	269	45	A	a	DT
cord-003302-vxk7uqlc	269	46	virus	virus	NN
cord-003302-vxk7uqlc	269	47	Reexamining	reexamine	VBG
cord-003302-vxk7uqlc	269	48	the	the	DT
cord-003302-vxk7uqlc	269	49	evidence	evidence	NN
cord-003302-vxk7uqlc	269	50	regarding	regard	VBG
cord-003302-vxk7uqlc	269	51	circulation	circulation	NN
cord-003302-vxk7uqlc	269	52	of	of	IN
cord-003302-vxk7uqlc	269	53	a	a	DT
cord-003302-vxk7uqlc	269	54	human	human	JJ
cord-003302-vxk7uqlc	269	55	H1	H1	NNP
cord-003302-vxk7uqlc	269	56	influenza	influenza	NN
cord-003302-vxk7uqlc	269	57	virus	virus	NN
cord-003302-vxk7uqlc	269	58	immediately	immediately	RB
cord-003302-vxk7uqlc	269	59	prior	prior	RB
cord-003302-vxk7uqlc	269	60	to	to	IN
cord-003302-vxk7uqlc	269	61	the	the	DT
cord-003302-vxk7uqlc	269	62	1918	1918	CD
cord-003302-vxk7uqlc	269	63	Spanish	spanish	JJ
cord-003302-vxk7uqlc	269	64	flu	flu	NN
cord-003302-vxk7uqlc	269	65	Potent	potent	JJ
cord-003302-vxk7uqlc	269	66	protection	protection	NN
cord-003302-vxk7uqlc	269	67	against	against	IN
cord-003302-vxk7uqlc	269	68	H5H1	H5H1	NNP
cord-003302-vxk7uqlc	269	69	and	and	CC
cord-003302-vxk7uqlc	269	70	H7N9	H7N9	NNP
cord-003302-vxk7uqlc	269	71	influenza	influenza	NN
cord-003302-vxk7uqlc	269	72	via	via	IN
cord-003302-vxk7uqlc	269	73	childhood	childhood	NN
cord-003302-vxk7uqlc	269	74	hemagglutinin	hemagglutinin	NN
cord-003302-vxk7uqlc	269	75	imprinting	imprinting	NN
cord-003302-vxk7uqlc	269	76	Searching	search	VBG
cord-003302-vxk7uqlc	269	77	for	for	IN
cord-003302-vxk7uqlc	269	78	sharp	sharp	JJ
cord-003302-vxk7uqlc	269	79	drops	drop	NNS
cord-003302-vxk7uqlc	269	80	in	in	IN
cord-003302-vxk7uqlc	269	81	the	the	DT
cord-003302-vxk7uqlc	269	82	incidence	incidence	NN
cord-003302-vxk7uqlc	269	83	of	of	IN
cord-003302-vxk7uqlc	269	84	pandemic	pandemic	NN
cord-003302-vxk7uqlc	269	85	A	A	NNP
cord-003302-vxk7uqlc	269	86	/	/	SYM
cord-003302-vxk7uqlc	269	87	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	269	88	influenza	influenza	NN
cord-003302-vxk7uqlc	269	89	by	by	IN
cord-003302-vxk7uqlc	269	90	single	single	JJ
cord-003302-vxk7uqlc	269	91	year	year	NN
cord-003302-vxk7uqlc	269	92	of	of	IN
cord-003302-vxk7uqlc	269	93	age	age	NN
cord-003302-vxk7uqlc	269	94	Pandemic	Pandemic	NNP
cord-003302-vxk7uqlc	269	95	paradox	paradox	NN
cord-003302-vxk7uqlc	269	96	:	:	:
cord-003302-vxk7uqlc	269	97	early	early	JJ
cord-003302-vxk7uqlc	269	98	life	life	NN
cord-003302-vxk7uqlc	269	99	H2N2	H2N2	NNP
cord-003302-vxk7uqlc	269	100	pandemic	pandemic	NN
cord-003302-vxk7uqlc	269	101	influenza	influenza	NN
cord-003302-vxk7uqlc	269	102	infection	infection	NN
cord-003302-vxk7uqlc	269	103	enhanced	enhance	VBD
cord-003302-vxk7uqlc	269	104	susceptibility	susceptibility	NN
cord-003302-vxk7uqlc	269	105	to	to	IN
cord-003302-vxk7uqlc	269	106	death	death	NN
cord-003302-vxk7uqlc	269	107	during	during	IN
cord-003302-vxk7uqlc	269	108	the	the	DT
cord-003302-vxk7uqlc	269	109	2009	2009	CD
cord-003302-vxk7uqlc	269	110	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	269	111	pandemic	pandemic	NN
cord-003302-vxk7uqlc	269	112	First	first	JJ
cord-003302-vxk7uqlc	269	113	flu	flu	NN
cord-003302-vxk7uqlc	269	114	is	be	VBZ
cord-003302-vxk7uqlc	269	115	forever	forever	RB
cord-003302-vxk7uqlc	269	116	Imprinting	imprinting	NN
cord-003302-vxk7uqlc	269	117	of	of	IN
cord-003302-vxk7uqlc	269	118	repeated	repeat	VBN
cord-003302-vxk7uqlc	269	119	influenza	influenza	NN
cord-003302-vxk7uqlc	269	120	A	A	NNP
cord-003302-vxk7uqlc	269	121	/	/	SYM
cord-003302-vxk7uqlc	269	122	H3	H3	NNP
cord-003302-vxk7uqlc	269	123	exposures	exposure	NNS
cord-003302-vxk7uqlc	269	124	on	on	IN
cord-003302-vxk7uqlc	269	125	antibody	antibody	NN
cord-003302-vxk7uqlc	269	126	quantity	quantity	NN
cord-003302-vxk7uqlc	269	127	and	and	CC
cord-003302-vxk7uqlc	269	128	antibody	antibody	NN
cord-003302-vxk7uqlc	269	129	quality	quality	NN
cord-003302-vxk7uqlc	269	130	:	:	:
cord-003302-vxk7uqlc	269	131	implications	implication	NNS
cord-003302-vxk7uqlc	269	132	on	on	IN
cord-003302-vxk7uqlc	269	133	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	269	134	vaccine	vaccine	NN
cord-003302-vxk7uqlc	269	135	strain	strain	NN
cord-003302-vxk7uqlc	269	136	selection	selection	NN
cord-003302-vxk7uqlc	269	137	and	and	CC
cord-003302-vxk7uqlc	269	138	vaccine	vaccine	NN
cord-003302-vxk7uqlc	269	139	performance	performance	NN
cord-003302-vxk7uqlc	269	140	Childhood	Childhood	NNP
cord-003302-vxk7uqlc	269	141	tolerance	tolerance	NN
cord-003302-vxk7uqlc	269	142	of	of	IN
cord-003302-vxk7uqlc	269	143	severe	severe	JJ
cord-003302-vxk7uqlc	269	144	influenza	influenza	NN
cord-003302-vxk7uqlc	269	145	:	:	:
cord-003302-vxk7uqlc	269	146	a	a	DT
cord-003302-vxk7uqlc	269	147	mortality	mortality	NN
cord-003302-vxk7uqlc	269	148	analysis	analysis	NN
cord-003302-vxk7uqlc	269	149	in	in	IN
cord-003302-vxk7uqlc	269	150	mice	mouse	NNS
cord-003302-vxk7uqlc	270	1	Elevated	elevated	JJ
cord-003302-vxk7uqlc	270	2	17b	17b	NNS
cord-003302-vxk7uqlc	270	3	-	-	HYPH
cord-003302-vxk7uqlc	270	4	estradiol	estradiol	NN
cord-003302-vxk7uqlc	270	5	protects	protect	VBZ
cord-003302-vxk7uqlc	270	6	females	female	NNS
cord-003302-vxk7uqlc	270	7	from	from	IN
cord-003302-vxk7uqlc	270	8	influenza	influenza	NN
cord-003302-vxk7uqlc	270	9	A	a	DT
cord-003302-vxk7uqlc	270	10	virus	virus	NN
cord-003302-vxk7uqlc	270	11	pathogenesis	pathogenesis	NN
cord-003302-vxk7uqlc	270	12	by	by	IN
cord-003302-vxk7uqlc	270	13	suppressing	suppress	VBG
cord-003302-vxk7uqlc	270	14	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	270	15	responses	response	NNS
cord-003302-vxk7uqlc	270	16	Characterising	characterise	VBG
cord-003302-vxk7uqlc	270	17	pre	pre	JJ
cord-003302-vxk7uqlc	270	18	-	-	JJ
cord-003302-vxk7uqlc	270	19	pubertal	pubertal	JJ
cord-003302-vxk7uqlc	270	20	resistance	resistance	NN
cord-003302-vxk7uqlc	270	21	to	to	IN
cord-003302-vxk7uqlc	270	22	death	death	NN
cord-003302-vxk7uqlc	270	23	from	from	IN
cord-003302-vxk7uqlc	270	24	endotoxemia	endotoxemia	NN
cord-003302-vxk7uqlc	270	25	Genomic	genomic	JJ
cord-003302-vxk7uqlc	270	26	responses	response	NNS
cord-003302-vxk7uqlc	270	27	in	in	IN
cord-003302-vxk7uqlc	270	28	mouse	mouse	NN
cord-003302-vxk7uqlc	270	29	models	model	NNS
cord-003302-vxk7uqlc	270	30	greatly	greatly	RB
cord-003302-vxk7uqlc	270	31	mimic	mimic	VBP
cord-003302-vxk7uqlc	270	32	human	human	JJ
cord-003302-vxk7uqlc	270	33	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	270	34	diseases	disease	NNS
cord-003302-vxk7uqlc	271	1	The	the	DT
cord-003302-vxk7uqlc	271	2	future	future	NN
cord-003302-vxk7uqlc	271	3	of	of	IN
cord-003302-vxk7uqlc	271	4	murine	murine	JJ
cord-003302-vxk7uqlc	271	5	sepsis	sepsis	NN
cord-003302-vxk7uqlc	271	6	and	and	CC
cord-003302-vxk7uqlc	271	7	trauma	trauma	NN
cord-003302-vxk7uqlc	271	8	research	research	NN
cord-003302-vxk7uqlc	271	9	models	model	NNS
cord-003302-vxk7uqlc	272	1	Induction	induction	NN
cord-003302-vxk7uqlc	272	2	of	of	IN
cord-003302-vxk7uqlc	272	3	interleukin-1	interleukin-1	NN
cord-003302-vxk7uqlc	272	4	beta	beta	NN
cord-003302-vxk7uqlc	272	5	(	(	-LRB-
cord-003302-vxk7uqlc	272	6	IL-1b	IL-1b	NNP
cord-003302-vxk7uqlc	272	7	)	)	-RRB-
cord-003302-vxk7uqlc	272	8	is	be	VBZ
cord-003302-vxk7uqlc	272	9	a	a	DT
cord-003302-vxk7uqlc	272	10	critical	critical	JJ
cord-003302-vxk7uqlc	272	11	component	component	NN
cord-003302-vxk7uqlc	272	12	of	of	IN
cord-003302-vxk7uqlc	272	13	lung	lung	NN
cord-003302-vxk7uqlc	272	14	inflammation	inflammation	NN
cord-003302-vxk7uqlc	272	15	during	during	IN
cord-003302-vxk7uqlc	272	16	influenza	influenza	NN
cord-003302-vxk7uqlc	272	17	A	a	NN
cord-003302-vxk7uqlc	272	18	(	(	-LRB-
cord-003302-vxk7uqlc	272	19	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	272	20	)	)	-RRB-
cord-003302-vxk7uqlc	272	21	virus	virus	NN
cord-003302-vxk7uqlc	272	22	infection	infection	NN
cord-003302-vxk7uqlc	272	23	Human	Human	NNP
cord-003302-vxk7uqlc	272	24	influenza	influenza	NN
cord-003302-vxk7uqlc	272	25	virus	virus	NN
cord-003302-vxk7uqlc	272	26	infections	infection	NNS
cord-003302-vxk7uqlc	272	27	Mitochondrial	mitochondrial	JJ
cord-003302-vxk7uqlc	272	28	dysfunction	dysfunction	NN
cord-003302-vxk7uqlc	272	29	in	in	IN
cord-003302-vxk7uqlc	272	30	lung	lung	NN
cord-003302-vxk7uqlc	272	31	pathogenesis	pathogenesis	NN
cord-003302-vxk7uqlc	272	32	Identification	identification	NN
cord-003302-vxk7uqlc	272	33	of	of	IN
cord-003302-vxk7uqlc	272	34	oxidative	oxidative	JJ
cord-003302-vxk7uqlc	272	35	stress	stress	NN
cord-003302-vxk7uqlc	272	36	and	and	CC
cord-003302-vxk7uqlc	273	1	Tolllike	Tolllike	NNP
cord-003302-vxk7uqlc	273	2	receptor	receptor	NN
cord-003302-vxk7uqlc	273	3	4	4	CD
cord-003302-vxk7uqlc	273	4	signaling	signal	VBG
cord-003302-vxk7uqlc	273	5	as	as	IN
cord-003302-vxk7uqlc	273	6	a	a	DT
cord-003302-vxk7uqlc	273	7	key	key	JJ
cord-003302-vxk7uqlc	273	8	pathway	pathway	NN
cord-003302-vxk7uqlc	273	9	of	of	IN
cord-003302-vxk7uqlc	273	10	acute	acute	JJ
cord-003302-vxk7uqlc	273	11	lung	lung	NN
cord-003302-vxk7uqlc	273	12	injury	injury	NN
cord-003302-vxk7uqlc	274	1	The	the	DT
cord-003302-vxk7uqlc	274	2	role	role	NN
cord-003302-vxk7uqlc	274	3	of	of	IN
cord-003302-vxk7uqlc	274	4	oxidative	oxidative	JJ
cord-003302-vxk7uqlc	274	5	stress	stress	NN
cord-003302-vxk7uqlc	274	6	in	in	IN
cord-003302-vxk7uqlc	274	7	influenza	influenza	NN
cord-003302-vxk7uqlc	274	8	virus	virus	NN
cord-003302-vxk7uqlc	274	9	infection	infection	NN
cord-003302-vxk7uqlc	275	1	Endothelial	endothelial	JJ
cord-003302-vxk7uqlc	275	2	cells	cell	NNS
cord-003302-vxk7uqlc	275	3	are	be	VBP
cord-003302-vxk7uqlc	275	4	central	central	JJ
cord-003302-vxk7uqlc	275	5	orchestrators	orchestrator	NNS
cord-003302-vxk7uqlc	275	6	of	of	IN
cord-003302-vxk7uqlc	275	7	cytokine	cytokine	NN
cord-003302-vxk7uqlc	275	8	amplification	amplification	NN
cord-003302-vxk7uqlc	275	9	during	during	IN
cord-003302-vxk7uqlc	275	10	influenza	influenza	NN
cord-003302-vxk7uqlc	275	11	virus	virus	NN
cord-003302-vxk7uqlc	275	12	infection	infection	NN
cord-003302-vxk7uqlc	276	1	The	the	DT
cord-003302-vxk7uqlc	276	2	lung	lung	NN
cord-003302-vxk7uqlc	276	3	microvascular	microvascular	NN
cord-003302-vxk7uqlc	276	4	endothelium	endothelium	NN
cord-003302-vxk7uqlc	276	5	as	as	IN
cord-003302-vxk7uqlc	276	6	a	a	DT
cord-003302-vxk7uqlc	276	7	therapeutic	therapeutic	JJ
cord-003302-vxk7uqlc	276	8	target	target	NN
cord-003302-vxk7uqlc	276	9	in	in	IN
cord-003302-vxk7uqlc	276	10	severe	severe	JJ
cord-003302-vxk7uqlc	276	11	influenza	influenza	NN
cord-003302-vxk7uqlc	276	12	Lipidomic	Lipidomic	NNP
cord-003302-vxk7uqlc	276	13	profiling	profiling	NN
cord-003302-vxk7uqlc	276	14	of	of	IN
cord-003302-vxk7uqlc	276	15	influenza	influenza	NN
cord-003302-vxk7uqlc	276	16	infection	infection	NN
cord-003302-vxk7uqlc	276	17	identifies	identify	VBZ
cord-003302-vxk7uqlc	276	18	mediators	mediator	NNS
cord-003302-vxk7uqlc	276	19	that	that	WDT
cord-003302-vxk7uqlc	276	20	induce	induce	VBP
cord-003302-vxk7uqlc	276	21	and	and	CC
cord-003302-vxk7uqlc	276	22	resolve	resolve	VB
cord-003302-vxk7uqlc	276	23	inflammation	inflammation	NN
cord-003302-vxk7uqlc	277	1	Treating	treat	VBG
cord-003302-vxk7uqlc	277	2	inflammation	inflammation	NN
cord-003302-vxk7uqlc	277	3	and	and	CC
cord-003302-vxk7uqlc	277	4	infection	infection	NN
cord-003302-vxk7uqlc	277	5	in	in	IN
cord-003302-vxk7uqlc	277	6	the	the	DT
cord-003302-vxk7uqlc	277	7	21st	21st	JJ
cord-003302-vxk7uqlc	277	8	century	century	NN
cord-003302-vxk7uqlc	277	9	:	:	:
cord-003302-vxk7uqlc	277	10	new	new	JJ
cord-003302-vxk7uqlc	277	11	hints	hint	NNS
cord-003302-vxk7uqlc	277	12	from	from	IN
cord-003302-vxk7uqlc	277	13	decoding	decode	VBG
cord-003302-vxk7uqlc	277	14	resolution	resolution	NN
cord-003302-vxk7uqlc	277	15	mediators	mediator	NNS
cord-003302-vxk7uqlc	277	16	and	and	CC
cord-003302-vxk7uqlc	277	17	mechanisms	mechanism	NNS
cord-003302-vxk7uqlc	278	1	Perpetual	perpetual	JJ
cord-003302-vxk7uqlc	278	2	change	change	NN
cord-003302-vxk7uqlc	278	3	:	:	:
cord-003302-vxk7uqlc	279	1	autophagy	autophagy	NN
cord-003302-vxk7uqlc	279	2	,	,	,
cord-003302-vxk7uqlc	279	3	the	the	DT
cord-003302-vxk7uqlc	279	4	endothelium	endothelium	NN
cord-003302-vxk7uqlc	279	5	,	,	,
cord-003302-vxk7uqlc	279	6	and	and	CC
cord-003302-vxk7uqlc	279	7	response	response	NN
cord-003302-vxk7uqlc	279	8	to	to	IN
cord-003302-vxk7uqlc	279	9	vascular	vascular	JJ
cord-003302-vxk7uqlc	279	10	injury	injury	NN
cord-003302-vxk7uqlc	280	1	Autophagy	Autophagy	NNP
cord-003302-vxk7uqlc	280	2	induction	induction	NN
cord-003302-vxk7uqlc	280	3	regulates	regulate	VBZ
cord-003302-vxk7uqlc	280	4	influenza	influenza	NN
cord-003302-vxk7uqlc	280	5	virus	virus	NN
cord-003302-vxk7uqlc	280	6	replication	replication	NN
cord-003302-vxk7uqlc	280	7	in	in	IN
cord-003302-vxk7uqlc	280	8	a	a	DT
cord-003302-vxk7uqlc	280	9	time	time	NN
cord-003302-vxk7uqlc	280	10	-	-	HYPH
cord-003302-vxk7uqlc	280	11	dependent	dependent	JJ
cord-003302-vxk7uqlc	280	12	manner	manner	NN
cord-003302-vxk7uqlc	281	1	Inhibition	inhibition	NN
cord-003302-vxk7uqlc	281	2	of	of	IN
cord-003302-vxk7uqlc	281	3	autophagy	autophagy	NN
cord-003302-vxk7uqlc	281	4	ameliorates	ameliorate	VBZ
cord-003302-vxk7uqlc	281	5	acute	acute	JJ
cord-003302-vxk7uqlc	281	6	lung	lung	NN
cord-003302-vxk7uqlc	281	7	injury	injury	NN
cord-003302-vxk7uqlc	281	8	caused	cause	VBN
cord-003302-vxk7uqlc	281	9	by	by	IN
cord-003302-vxk7uqlc	281	10	avian	avian	JJ
cord-003302-vxk7uqlc	281	11	influenza	influenza	NN
cord-003302-vxk7uqlc	281	12	A	a	DT
cord-003302-vxk7uqlc	281	13	H5N1	H5N1	NNP
cord-003302-vxk7uqlc	281	14	infection	infection	NN
cord-003302-vxk7uqlc	281	15	Activation	activation	NN
cord-003302-vxk7uqlc	281	16	of	of	IN
cord-003302-vxk7uqlc	281	17	autophagy	autophagy	NN
cord-003302-vxk7uqlc	281	18	is	be	VBZ
cord-003302-vxk7uqlc	281	19	involved	involve	VBN
cord-003302-vxk7uqlc	281	20	in	in	IN
cord-003302-vxk7uqlc	281	21	the	the	DT
cord-003302-vxk7uqlc	281	22	protective	protective	JJ
cord-003302-vxk7uqlc	281	23	effect	effect	NN
cord-003302-vxk7uqlc	281	24	of	of	IN
cord-003302-vxk7uqlc	281	25	17b	17b	NNS
cord-003302-vxk7uqlc	281	26	-	-	HYPH
cord-003302-vxk7uqlc	281	27	oestradiol	oestradiol	NN
cord-003302-vxk7uqlc	281	28	on	on	IN
cord-003302-vxk7uqlc	281	29	endotoxaemia	endotoxaemia	NN
cord-003302-vxk7uqlc	281	30	-	-	HYPH
cord-003302-vxk7uqlc	281	31	induced	induce	VBN
cord-003302-vxk7uqlc	281	32	multiple	multiple	JJ
cord-003302-vxk7uqlc	281	33	organ	organ	NN
cord-003302-vxk7uqlc	281	34	dysfunction	dysfunction	NN
cord-003302-vxk7uqlc	281	35	in	in	IN
cord-003302-vxk7uqlc	281	36	ovariectomized	ovariectomize	VBN
cord-003302-vxk7uqlc	281	37	rats	rat	NNS
cord-003302-vxk7uqlc	281	38	Disease	Disease	NNP
cord-003302-vxk7uqlc	281	39	tolerance	tolerance	NN
cord-003302-vxk7uqlc	281	40	as	as	IN
cord-003302-vxk7uqlc	281	41	a	a	DT
cord-003302-vxk7uqlc	281	42	defense	defense	NN
cord-003302-vxk7uqlc	281	43	strategy	strategy	NN
cord-003302-vxk7uqlc	281	44	Disease	Disease	NNP
cord-003302-vxk7uqlc	281	45	tolerance	tolerance	NN
cord-003302-vxk7uqlc	281	46	and	and	CC
cord-003302-vxk7uqlc	281	47	immunity	immunity	NN
cord-003302-vxk7uqlc	281	48	in	in	IN
cord-003302-vxk7uqlc	281	49	host	host	NN
cord-003302-vxk7uqlc	281	50	protection	protection	NN
cord-003302-vxk7uqlc	281	51	against	against	IN
cord-003302-vxk7uqlc	281	52	infection	infection	NN
cord-003302-vxk7uqlc	281	53	Unravelling	unravel	VBG
cord-003302-vxk7uqlc	281	54	the	the	DT
cord-003302-vxk7uqlc	281	55	networks	network	NNS
cord-003302-vxk7uqlc	281	56	dictating	dictate	VBG
cord-003302-vxk7uqlc	281	57	host	host	NN
cord-003302-vxk7uqlc	281	58	resistance	resistance	NN
cord-003302-vxk7uqlc	281	59	versus	versus	IN
cord-003302-vxk7uqlc	281	60	tolerance	tolerance	NN
cord-003302-vxk7uqlc	281	61	during	during	IN
cord-003302-vxk7uqlc	281	62	pulmonary	pulmonary	JJ
cord-003302-vxk7uqlc	281	63	infections	infection	NNS
cord-003302-vxk7uqlc	281	64	KM	KM	NNP
cord-003302-vxk7uqlc	281	65	ES	ES	NNP
cord-003302-vxk7uqlc	281	66	1	1	CD
cord-003302-vxk7uqlc	281	67	Jamieson	Jamieson	NNP
cord-003302-vxk7uqlc	281	68	AM	AM	NNP
cord-003302-vxk7uqlc	281	69	.	.	.
cord-003302-vxk7uqlc	282	1	Surviving	survive	VBG
cord-003302-vxk7uqlc	282	2	deadly	deadly	JJ
cord-003302-vxk7uqlc	282	3	lung	lung	NN
cord-003302-vxk7uqlc	282	4	infections	infection	NNS
cord-003302-vxk7uqlc	282	5	:	:	:
cord-003302-vxk7uqlc	282	6	innate	innate	JJ
cord-003302-vxk7uqlc	282	7	host	host	NN
cord-003302-vxk7uqlc	282	8	tolerance	tolerance	NN
cord-003302-vxk7uqlc	282	9	mechanisms	mechanism	NNS
cord-003302-vxk7uqlc	282	10	in	in	IN
cord-003302-vxk7uqlc	282	11	the	the	DT
cord-003302-vxk7uqlc	282	12	pulmonary	pulmonary	JJ
cord-003302-vxk7uqlc	282	13	system	system	NN
cord-003302-vxk7uqlc	283	1	A	a	DT
cord-003302-vxk7uqlc	283	2	guide	guide	NN
cord-003302-vxk7uqlc	283	3	to	to	IN
cord-003302-vxk7uqlc	283	4	immunometabolism	immunometabolism	NN
cord-003302-vxk7uqlc	283	5	for	for	IN
cord-003302-vxk7uqlc	283	6	immunologists	immunologist	NNS
cord-003302-vxk7uqlc	283	7	Mitochondrial	Mitochondrial	NNP
cord-003302-vxk7uqlc	283	8	dynamics	dynamic	NNS
cord-003302-vxk7uqlc	283	9	at	at	IN
cord-003302-vxk7uqlc	283	10	the	the	DT
cord-003302-vxk7uqlc	283	11	interface	interface	NN
cord-003302-vxk7uqlc	283	12	of	of	IN
cord-003302-vxk7uqlc	283	13	immune	immune	JJ
cord-003302-vxk7uqlc	283	14	cell	cell	NN
cord-003302-vxk7uqlc	283	15	metabolism	metabolism	NN
cord-003302-vxk7uqlc	283	16	and	and	CC
cord-003302-vxk7uqlc	283	17	function	function	VB
cord-003302-vxk7uqlc	283	18	Estrogen	estrogen	NN
cord-003302-vxk7uqlc	283	19	receptors	receptor	NNS
cord-003302-vxk7uqlc	283	20	regulate	regulate	VBP
cord-003302-vxk7uqlc	283	21	innate	innate	JJ
cord-003302-vxk7uqlc	283	22	immune	immune	JJ
cord-003302-vxk7uqlc	283	23	cells	cell	NNS
cord-003302-vxk7uqlc	283	24	and	and	CC
cord-003302-vxk7uqlc	283	25	signaling	signal	VBG
cord-003302-vxk7uqlc	283	26	pathways	pathway	NNS
cord-003302-vxk7uqlc	283	27	Metabolic	metabolic	JJ
cord-003302-vxk7uqlc	283	28	pathways	pathway	NNS
cord-003302-vxk7uqlc	283	29	of	of	IN
cord-003302-vxk7uqlc	283	30	lung	lung	NN
cord-003302-vxk7uqlc	283	31	inflammation	inflammation	NN
cord-003302-vxk7uqlc	283	32	revealed	reveal	VBN
cord-003302-vxk7uqlc	283	33	by	by	IN
cord-003302-vxk7uqlc	283	34	high	high	JJ
cord-003302-vxk7uqlc	283	35	-	-	HYPH
cord-003302-vxk7uqlc	283	36	resolution	resolution	NN
cord-003302-vxk7uqlc	283	37	metabolomics	metabolomic	NNS
cord-003302-vxk7uqlc	283	38	(	(	-LRB-
cord-003302-vxk7uqlc	283	39	HRM	HRM	NNP
cord-003302-vxk7uqlc	283	40	)	)	-RRB-
cord-003302-vxk7uqlc	283	41	of	of	IN
cord-003302-vxk7uqlc	283	42	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	283	43	influenza	influenza	NN
cord-003302-vxk7uqlc	283	44	virus	virus	NN
cord-003302-vxk7uqlc	283	45	infection	infection	NN
cord-003302-vxk7uqlc	283	46	in	in	IN
cord-003302-vxk7uqlc	283	47	mice	mouse	NNS
cord-003302-vxk7uqlc	283	48	Endocrinology	Endocrinology	NNP
cord-003302-vxk7uqlc	283	49	,	,	,
cord-003302-vxk7uqlc	283	50	energetics	energetic	NNS
cord-003302-vxk7uqlc	283	51	,	,	,
cord-003302-vxk7uqlc	283	52	and	and	CC
cord-003302-vxk7uqlc	283	53	human	human	JJ
cord-003302-vxk7uqlc	283	54	life	life	NN
cord-003302-vxk7uqlc	283	55	history	history	NN
cord-003302-vxk7uqlc	283	56	:	:	:
cord-003302-vxk7uqlc	283	57	a	a	DT
cord-003302-vxk7uqlc	283	58	synthetic	synthetic	JJ
cord-003302-vxk7uqlc	283	59	model	model	NN
cord-003302-vxk7uqlc	283	60	Natural	Natural	NNP
cord-003302-vxk7uqlc	283	61	T	T	NNP
cord-003302-vxk7uqlc	283	62	cell	cell	NN
cord-003302-vxk7uqlc	283	63	-	-	HYPH
cord-003302-vxk7uqlc	283	64	mediated	mediate	VBN
cord-003302-vxk7uqlc	283	65	protection	protection	NN
cord-003302-vxk7uqlc	283	66	against	against	IN
cord-003302-vxk7uqlc	283	67	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	283	68	and	and	CC
cord-003302-vxk7uqlc	283	69	pandemic	pandemic	NN
cord-003302-vxk7uqlc	283	70	influenza	influenza	NN
cord-003302-vxk7uqlc	283	71	.	.	.
cord-003302-vxk7uqlc	284	1	Results	result	NNS
cord-003302-vxk7uqlc	284	2	of	of	IN
cord-003302-vxk7uqlc	284	3	the	the	DT
cord-003302-vxk7uqlc	284	4	Flu	Flu	NNP
cord-003302-vxk7uqlc	284	5	Watch	Watch	NNP
cord-003302-vxk7uqlc	284	6	Cohort	Cohort	NNP
cord-003302-vxk7uqlc	284	7	Study	Study	NNP
cord-003302-vxk7uqlc	284	8	Human	Human	NNP
cord-003302-vxk7uqlc	284	9	genetic	genetic	JJ
cord-003302-vxk7uqlc	284	10	basis	basis	NN
cord-003302-vxk7uqlc	284	11	of	of	IN
cord-003302-vxk7uqlc	284	12	interindividual	interindividual	JJ
cord-003302-vxk7uqlc	284	13	variability	variability	NN
cord-003302-vxk7uqlc	284	14	in	in	IN
cord-003302-vxk7uqlc	284	15	the	the	DT
cord-003302-vxk7uqlc	284	16	course	course	NN
cord-003302-vxk7uqlc	284	17	of	of	IN
cord-003302-vxk7uqlc	284	18	infection	infection	NN
cord-003302-vxk7uqlc	284	19	Distinctive	distinctive	JJ
cord-003302-vxk7uqlc	284	20	roles	role	NNS
cord-003302-vxk7uqlc	284	21	of	of	IN
cord-003302-vxk7uqlc	284	22	age	age	NN
cord-003302-vxk7uqlc	284	23	,	,	,
cord-003302-vxk7uqlc	284	24	sex	sex	NN
cord-003302-vxk7uqlc	284	25	,	,	,
cord-003302-vxk7uqlc	284	26	and	and	CC
cord-003302-vxk7uqlc	284	27	genetics	genetics	NN
cord-003302-vxk7uqlc	284	28	in	in	IN
cord-003302-vxk7uqlc	284	29	shaping	shape	VBG
cord-003302-vxk7uqlc	284	30	transcriptional	transcriptional	JJ
cord-003302-vxk7uqlc	284	31	variation	variation	NN
cord-003302-vxk7uqlc	284	32	of	of	IN
cord-003302-vxk7uqlc	284	33	human	human	JJ
cord-003302-vxk7uqlc	284	34	immune	immune	JJ
cord-003302-vxk7uqlc	284	35	responses	response	NNS
cord-003302-vxk7uqlc	284	36	to	to	IN
cord-003302-vxk7uqlc	284	37	microbial	microbial	JJ
cord-003302-vxk7uqlc	284	38	challenges	challenge	NNS
cord-003302-vxk7uqlc	284	39	Differential	differential	JJ
cord-003302-vxk7uqlc	284	40	evolution	evolution	NN
cord-003302-vxk7uqlc	284	41	of	of	IN
cord-003302-vxk7uqlc	284	42	peripheral	peripheral	JJ
cord-003302-vxk7uqlc	284	43	cytokine	cytokine	NN
cord-003302-vxk7uqlc	284	44	levels	level	NNS
cord-003302-vxk7uqlc	284	45	in	in	IN
cord-003302-vxk7uqlc	284	46	symptomatic	symptomatic	JJ
cord-003302-vxk7uqlc	284	47	and	and	CC
cord-003302-vxk7uqlc	284	48	asymptomatic	asymptomatic	JJ
cord-003302-vxk7uqlc	284	49	responses	response	NNS
cord-003302-vxk7uqlc	284	50	to	to	IN
cord-003302-vxk7uqlc	285	1	experimental	experimental	JJ
cord-003302-vxk7uqlc	285	2	influenza	influenza	NN
cord-003302-vxk7uqlc	285	3	virus	virus	NN
cord-003302-vxk7uqlc	285	4	challenge	challenge	VBP
cord-003302-vxk7uqlc	285	5	Temporal	Temporal	NNP
cord-003302-vxk7uqlc	285	6	dynamics	dynamic	NNS
cord-003302-vxk7uqlc	285	7	of	of	IN
cord-003302-vxk7uqlc	285	8	host	host	NN
cord-003302-vxk7uqlc	285	9	molecular	molecular	JJ
cord-003302-vxk7uqlc	285	10	responses	response	NNS
cord-003302-vxk7uqlc	285	11	differentiate	differentiate	VBP
cord-003302-vxk7uqlc	285	12	symptomatic	symptomatic	JJ
cord-003302-vxk7uqlc	285	13	and	and	CC
cord-003302-vxk7uqlc	285	14	asymptomatic	asymptomatic	JJ
cord-003302-vxk7uqlc	285	15	influenza	influenza	NN
cord-003302-vxk7uqlc	285	16	a	a	DT
cord-003302-vxk7uqlc	285	17	infection	infection	NN
cord-003302-vxk7uqlc	285	18	Mitochondria	Mitochondria	NNP
cord-003302-vxk7uqlc	285	19	and	and	CC
cord-003302-vxk7uqlc	285	20	epigeneticscrosstalk	epigeneticscrosstalk	VB
cord-003302-vxk7uqlc	285	21	in	in	IN
cord-003302-vxk7uqlc	285	22	homeostasis	homeostasis	NN
cord-003302-vxk7uqlc	285	23	and	and	CC
cord-003302-vxk7uqlc	285	24	stress	stress	NN
cord-003302-vxk7uqlc	285	25	Epigenetic	epigenetic	JJ
cord-003302-vxk7uqlc	285	26	and	and	CC
cord-003302-vxk7uqlc	285	27	transcriptomic	transcriptomic	JJ
cord-003302-vxk7uqlc	285	28	regulation	regulation	NN
cord-003302-vxk7uqlc	285	29	of	of	IN
cord-003302-vxk7uqlc	285	30	lung	lung	NN
cord-003302-vxk7uqlc	285	31	repair	repair	NN
cord-003302-vxk7uqlc	285	32	during	during	IN
cord-003302-vxk7uqlc	285	33	recovery	recovery	NN
cord-003302-vxk7uqlc	285	34	from	from	IN
cord-003302-vxk7uqlc	285	35	influenza	influenza	NN
cord-003302-vxk7uqlc	285	36	infection	infection	NN
cord-003302-vxk7uqlc	286	1	The	the	DT
cord-003302-vxk7uqlc	286	2	key	key	JJ
cord-003302-vxk7uqlc	286	3	role	role	NN
cord-003302-vxk7uqlc	286	4	of	of	IN
cord-003302-vxk7uqlc	286	5	epigenetics	epigenetic	NNS
cord-003302-vxk7uqlc	286	6	in	in	IN
cord-003302-vxk7uqlc	286	7	human	human	JJ
cord-003302-vxk7uqlc	286	8	disease	disease	NN
cord-003302-vxk7uqlc	286	9	prevention	prevention	NN
cord-003302-vxk7uqlc	286	10	and	and	CC
cord-003302-vxk7uqlc	286	11	mitigation	mitigation	NN
cord-003302-vxk7uqlc	286	12	Human	human	JJ
cord-003302-vxk7uqlc	286	13	mortality	mortality	NN
cord-003302-vxk7uqlc	286	14	improvement	improvement	NN
cord-003302-vxk7uqlc	286	15	in	in	IN
cord-003302-vxk7uqlc	286	16	evolutionary	evolutionary	JJ
cord-003302-vxk7uqlc	286	17	context	context	NN
cord-003302-vxk7uqlc	286	18	Metabolic	metabolic	JJ
cord-003302-vxk7uqlc	286	19	stressors	stressor	NNS
cord-003302-vxk7uqlc	286	20	and	and	CC
cord-003302-vxk7uqlc	286	21	signals	signal	NNS
cord-003302-vxk7uqlc	286	22	differentially	differentially	RB
cord-003302-vxk7uqlc	286	23	affect	affect	VBP
cord-003302-vxk7uqlc	286	24	energy	energy	NN
cord-003302-vxk7uqlc	286	25	allocation	allocation	NN
cord-003302-vxk7uqlc	286	26	between	between	IN
cord-003302-vxk7uqlc	286	27	reproduction	reproduction	NN
cord-003302-vxk7uqlc	286	28	and	and	CC
cord-003302-vxk7uqlc	286	29	immune	immune	JJ
cord-003302-vxk7uqlc	286	30	function	function	NN
cord-003302-vxk7uqlc	287	1	Estrogens	estrogen	NNS
cord-003302-vxk7uqlc	287	2	and	and	CC
cord-003302-vxk7uqlc	287	3	the	the	DT
cord-003302-vxk7uqlc	287	4	control	control	NN
cord-003302-vxk7uqlc	287	5	of	of	IN
cord-003302-vxk7uqlc	287	6	energy	energy	NNP
cord-003302-vxk7uqlc	287	7	homeostasis	homeostasis	NN
cord-003302-vxk7uqlc	287	8	:	:	:
cord-003302-vxk7uqlc	287	9	a	a	DT
cord-003302-vxk7uqlc	287	10	brain	brain	NN
cord-003302-vxk7uqlc	287	11	perspective	perspective	NN
cord-003302-vxk7uqlc	288	1	The	the	DT
cord-003302-vxk7uqlc	288	2	emerging	emerge	VBG
cord-003302-vxk7uqlc	288	3	role	role	NN
cord-003302-vxk7uqlc	288	4	of	of	IN
cord-003302-vxk7uqlc	288	5	epigenetics	epigenetic	NNS
cord-003302-vxk7uqlc	288	6	in	in	IN
cord-003302-vxk7uqlc	288	7	the	the	DT
cord-003302-vxk7uqlc	288	8	regulation	regulation	NN
cord-003302-vxk7uqlc	288	9	of	of	IN
cord-003302-vxk7uqlc	288	10	female	female	JJ
cord-003302-vxk7uqlc	288	11	puberty	puberty	NN
cord-003302-vxk7uqlc	288	12	Differential	differential	NN
cord-003302-vxk7uqlc	288	13	pathological	pathological	JJ
cord-003302-vxk7uqlc	288	14	and	and	CC
cord-003302-vxk7uqlc	288	15	immune	immune	JJ
cord-003302-vxk7uqlc	288	16	responses	response	NNS
cord-003302-vxk7uqlc	288	17	in	in	IN
cord-003302-vxk7uqlc	288	18	newly	newly	RB
cord-003302-vxk7uqlc	288	19	weaned	wean	VBN
cord-003302-vxk7uqlc	288	20	ferrets	ferret	NNS
cord-003302-vxk7uqlc	288	21	are	be	VBP
cord-003302-vxk7uqlc	288	22	associated	associate	VBN
cord-003302-vxk7uqlc	288	23	with	with	IN
cord-003302-vxk7uqlc	288	24	a	a	DT
cord-003302-vxk7uqlc	288	25	mild	mild	JJ
cord-003302-vxk7uqlc	288	26	clinical	clinical	JJ
cord-003302-vxk7uqlc	288	27	outcome	outcome	NN
cord-003302-vxk7uqlc	288	28	of	of	IN
cord-003302-vxk7uqlc	288	29	pandemic	pandemic	NN
cord-003302-vxk7uqlc	288	30	2009	2009	CD
cord-003302-vxk7uqlc	288	31	H1N1	H1N1	NNP
cord-003302-vxk7uqlc	288	32	infection	infection	NN
cord-003302-vxk7uqlc	288	33	A	a	DT
cord-003302-vxk7uqlc	288	34	mouse	mouse	NN
cord-003302-vxk7uqlc	288	35	model	model	NN
cord-003302-vxk7uqlc	288	36	with	with	IN
cord-003302-vxk7uqlc	288	37	age	age	NN
cord-003302-vxk7uqlc	288	38	-	-	HYPH
cord-003302-vxk7uqlc	288	39	dependent	dependent	JJ
cord-003302-vxk7uqlc	288	40	immune	immune	JJ
cord-003302-vxk7uqlc	288	41	response	response	NN
cord-003302-vxk7uqlc	288	42	and	and	CC
cord-003302-vxk7uqlc	288	43	immune	immune	JJ
cord-003302-vxk7uqlc	288	44	-	-	HYPH
cord-003302-vxk7uqlc	288	45	tolerance	tolerance	NN
cord-003302-vxk7uqlc	288	46	for	for	IN
cord-003302-vxk7uqlc	288	47	HBV	HBV	NNP
cord-003302-vxk7uqlc	288	48	infection	infection	NN
cord-003302-vxk7uqlc	289	1	Endotoxin	endotoxin	NN
cord-003302-vxk7uqlc	289	2	induces	induce	VBZ
cord-003302-vxk7uqlc	289	3	an	an	DT
cord-003302-vxk7uqlc	289	4	exaggerated	exaggerated	JJ
cord-003302-vxk7uqlc	289	5	interleukin-10	interleukin-10	NN
cord-003302-vxk7uqlc	289	6	response	response	NN
cord-003302-vxk7uqlc	289	7	in	in	IN
cord-003302-vxk7uqlc	289	8	peritoneal	peritoneal	JJ
cord-003302-vxk7uqlc	289	9	macrophages	macrophage	NNS
cord-003302-vxk7uqlc	289	10	of	of	IN
cord-003302-vxk7uqlc	289	11	children	child	NNS
cord-003302-vxk7uqlc	289	12	compared	compare	VBN
cord-003302-vxk7uqlc	289	13	with	with	IN
cord-003302-vxk7uqlc	289	14	adults	adult	NNS
cord-003302-vxk7uqlc	290	1	IL-1beta	IL-1beta	NNP
cord-003302-vxk7uqlc	290	2	induces	induce	VBZ
cord-003302-vxk7uqlc	290	3	an	an	DT
cord-003302-vxk7uqlc	290	4	exaggerated	exaggerated	JJ
cord-003302-vxk7uqlc	290	5	pro	pro	JJ
cord-003302-vxk7uqlc	290	6	-	-	JJ
cord-003302-vxk7uqlc	290	7	and	and	CC
cord-003302-vxk7uqlc	290	8	anti	anti	JJ
cord-003302-vxk7uqlc	290	9	-	-	JJ
cord-003302-vxk7uqlc	290	10	inflammatory	inflammatory	JJ
cord-003302-vxk7uqlc	290	11	response	response	NN
cord-003302-vxk7uqlc	290	12	in	in	IN
cord-003302-vxk7uqlc	290	13	peritoneal	peritoneal	JJ
cord-003302-vxk7uqlc	290	14	macrophages	macrophage	NNS
cord-003302-vxk7uqlc	290	15	of	of	IN
cord-003302-vxk7uqlc	290	16	children	child	NNS
cord-003302-vxk7uqlc	290	17	compared	compare	VBN
cord-003302-vxk7uqlc	290	18	with	with	IN
cord-003302-vxk7uqlc	290	19	adults	adult	NNS
cord-003302-vxk7uqlc	290	20	Locus	locus	NN
cord-003302-vxk7uqlc	290	21	-	-	HYPH
cord-003302-vxk7uqlc	290	22	specific	specific	JJ
cord-003302-vxk7uqlc	290	23	reversible	reversible	JJ
cord-003302-vxk7uqlc	290	24	DNA	dna	NN
cord-003302-vxk7uqlc	290	25	methylation	methylation	NN
cord-003302-vxk7uqlc	290	26	regulates	regulate	VBZ
cord-003302-vxk7uqlc	290	27	transient	transient	JJ
cord-003302-vxk7uqlc	290	28	IL-10	IL-10	NNP
cord-003302-vxk7uqlc	290	29	expression	expression	NN
cord-003302-vxk7uqlc	290	30	in	in	IN
cord-003302-vxk7uqlc	290	31	Th1	th1	NN
cord-003302-vxk7uqlc	290	32	cells	cell	NNS
cord-003302-vxk7uqlc	290	33	Activation	Activation	NNP
cord-003302-vxk7uqlc	290	34	of	of	IN
cord-003302-vxk7uqlc	290	35	peroxisome	peroxisome	NN
cord-003302-vxk7uqlc	290	36	proliferatoractivated	proliferatoractivated	JJ
cord-003302-vxk7uqlc	290	37	receptor	receptor	NN
cord-003302-vxk7uqlc	290	38	-	-	HYPH
cord-003302-vxk7uqlc	290	39	gamma	gamma	NN
cord-003302-vxk7uqlc	290	40	during	during	IN
cord-003302-vxk7uqlc	290	41	hepatic	hepatic	JJ
cord-003302-vxk7uqlc	290	42	ischemia	ischemia	NN
cord-003302-vxk7uqlc	290	43	is	be	VBZ
cord-003302-vxk7uqlc	290	44	age	age	NN
cord-003302-vxk7uqlc	290	45	-	-	HYPH
cord-003302-vxk7uqlc	290	46	dependent	dependent	JJ
cord-003302-vxk7uqlc	290	47	Pleiotropic	Pleiotropic	NNP
cord-003302-vxk7uqlc	290	48	effects	effect	NNS
cord-003302-vxk7uqlc	290	49	of	of	IN
cord-003302-vxk7uqlc	290	50	statins	statin	NNS
cord-003302-vxk7uqlc	290	51	on	on	IN
cord-003302-vxk7uqlc	290	52	the	the	DT
cord-003302-vxk7uqlc	290	53	cardiovascular	cardiovascular	JJ
cord-003302-vxk7uqlc	290	54	system	system	NN
cord-003302-vxk7uqlc	290	55	Effects	effect	NNS
cord-003302-vxk7uqlc	290	56	of	of	IN
cord-003302-vxk7uqlc	290	57	ACE	ace	NN
cord-003302-vxk7uqlc	290	58	-	-	HYPH
cord-003302-vxk7uqlc	290	59	inhibitors	inhibitor	NNS
cord-003302-vxk7uqlc	290	60	and	and	CC
cord-003302-vxk7uqlc	290	61	angiotensin	angiotensin	NN
cord-003302-vxk7uqlc	290	62	receptor	receptor	NN
cord-003302-vxk7uqlc	290	63	blockers	blocker	NNS
cord-003302-vxk7uqlc	290	64	on	on	IN
cord-003302-vxk7uqlc	290	65	inflammation	inflammation	NN
cord-003302-vxk7uqlc	290	66	Metformin	Metformin	NNP
cord-003302-vxk7uqlc	290	67	and	and	CC
cord-003302-vxk7uqlc	290	68	inflammation	inflammation	NN
cord-003302-vxk7uqlc	290	69	:	:	:
cord-003302-vxk7uqlc	290	70	its	-PRON-	PRP$
cord-003302-vxk7uqlc	290	71	potential	potential	NN
cord-003302-vxk7uqlc	290	72	beyond	beyond	IN
cord-003302-vxk7uqlc	290	73	glucoselowering	glucoselowering	NN
cord-003302-vxk7uqlc	290	74	effect	effect	NN
cord-003302-vxk7uqlc	290	75	Estimation	estimation	NN
cord-003302-vxk7uqlc	290	76	of	of	IN
cord-003302-vxk7uqlc	290	77	potential	potential	JJ
cord-003302-vxk7uqlc	290	78	global	global	JJ
cord-003302-vxk7uqlc	290	79	pandemic	pandemic	NN
cord-003302-vxk7uqlc	290	80	influenza	influenza	NN
cord-003302-vxk7uqlc	290	81	mortality	mortality	NN
cord-003302-vxk7uqlc	290	82	on	on	IN
cord-003302-vxk7uqlc	290	83	the	the	DT
cord-003302-vxk7uqlc	290	84	basis	basis	NN
cord-003302-vxk7uqlc	290	85	of	of	IN
cord-003302-vxk7uqlc	290	86	vital	vital	JJ
cord-003302-vxk7uqlc	290	87	registry	registry	NN
cord-003302-vxk7uqlc	290	88	data	datum	NNS
cord-003302-vxk7uqlc	290	89	from	from	IN
cord-003302-vxk7uqlc	290	90	the	the	DT
cord-003302-vxk7uqlc	290	91	1918	1918	CD
cord-003302-vxk7uqlc	290	92	-	-	SYM
cord-003302-vxk7uqlc	290	93	20	20	CD
cord-003302-vxk7uqlc	290	94	pandemic	pandemic	NN
cord-003302-vxk7uqlc	290	95	:	:	:
cord-003302-vxk7uqlc	290	96	a	a	DT
cord-003302-vxk7uqlc	290	97	quantitative	quantitative	JJ
cord-003302-vxk7uqlc	290	98	analysis	analysis	NN
cord-003302-vxk7uqlc	290	99	Innovation	innovation	NN
cord-003302-vxk7uqlc	290	100	for	for	IN
cord-003302-vxk7uqlc	290	101	pandemics	pandemic	NNS
cord-003302-vxk7uqlc	290	102	H7N9	H7N9	NNP
cord-003302-vxk7uqlc	290	103	virulent	virulent	JJ
cord-003302-vxk7uqlc	290	104	mutants	mutant	NNS
cord-003302-vxk7uqlc	290	105	detected	detect	VBN
cord-003302-vxk7uqlc	290	106	in	in	IN
cord-003302-vxk7uqlc	290	107	chickens	chicken	NNS
cord-003302-vxk7uqlc	290	108	in	in	IN
cord-003302-vxk7uqlc	290	109	China	China	NNP
cord-003302-vxk7uqlc	290	110	pose	pose	VBP
cord-003302-vxk7uqlc	290	111	an	an	DT
cord-003302-vxk7uqlc	290	112	increased	increase	VBN
cord-003302-vxk7uqlc	290	113	threat	threat	NN
cord-003302-vxk7uqlc	290	114	to	to	IN
cord-003302-vxk7uqlc	290	115	humans	human	NNS
cord-003302-vxk7uqlc	290	116	Estimates	estimate	NNS
cord-003302-vxk7uqlc	290	117	of	of	IN
cord-003302-vxk7uqlc	290	118	global	global	JJ
cord-003302-vxk7uqlc	290	119	seasonal	seasonal	JJ
cord-003302-vxk7uqlc	290	120	influenza	influenza	NN
cord-003302-vxk7uqlc	290	121	-	-	HYPH
cord-003302-vxk7uqlc	290	122	associated	associate	VBN
cord-003302-vxk7uqlc	290	123	respiratory	respiratory	JJ
cord-003302-vxk7uqlc	290	124	mortality	mortality	NN
cord-003302-vxk7uqlc	290	125	:	:	:
cord-003302-vxk7uqlc	291	1	a	a	DT
cord-003302-vxk7uqlc	291	2	modeling	modeling	NN
cord-003302-vxk7uqlc	291	3	study	study	NN
cord-003302-vxk7uqlc	292	1	The	the	DT
cord-003302-vxk7uqlc	292	2	pathway	pathway	NN
cord-003302-vxk7uqlc	292	3	to	to	IN
cord-003302-vxk7uqlc	292	4	a	a	DT
cord-003302-vxk7uqlc	292	5	universal	universal	JJ
cord-003302-vxk7uqlc	292	6	influenza	influenza	NN
cord-003302-vxk7uqlc	292	7	vaccine	vaccine	NN
cord-003302-vxk7uqlc	292	8	Natural	Natural	NNP
cord-003302-vxk7uqlc	292	9	and	and	CC
cord-003302-vxk7uqlc	292	10	directed	direct	VBD
cord-003302-vxk7uqlc	292	11	antigenic	antigenic	JJ
cord-003302-vxk7uqlc	292	12	drift	drift	NN
cord-003302-vxk7uqlc	292	13	of	of	IN
cord-003302-vxk7uqlc	292	14	the	the	DT
cord-003302-vxk7uqlc	292	15	H1	H1	NNP
cord-003302-vxk7uqlc	292	16	influenza	influenza	NN
cord-003302-vxk7uqlc	292	17	virus	virus	NN
cord-003302-vxk7uqlc	292	18	hemagglutinin	hemagglutinin	NN
cord-003302-vxk7uqlc	292	19	stalk	stalk	VBP
cord-003302-vxk7uqlc	292	20	domain	domain	NN
cord-003302-vxk7uqlc	292	21	Evaluation	evaluation	NN
cord-003302-vxk7uqlc	292	22	of	of	IN
cord-003302-vxk7uqlc	292	23	pre	pre	JJ
cord-003302-vxk7uqlc	292	24	-	-	JJ
cord-003302-vxk7uqlc	292	25	existing	existing	JJ
cord-003302-vxk7uqlc	292	26	antihemagglutinin	antihemagglutinin	NNP
cord-003302-vxk7uqlc	292	27	stalk	stalk	NN
cord-003302-vxk7uqlc	292	28	antibody	antibody	NN
cord-003302-vxk7uqlc	292	29	as	as	IN
cord-003302-vxk7uqlc	292	30	a	a	DT
cord-003302-vxk7uqlc	292	31	correlate	correlate	NN
cord-003302-vxk7uqlc	292	32	of	of	IN
cord-003302-vxk7uqlc	292	33	protection	protection	NN
cord-003302-vxk7uqlc	292	34	in	in	IN
cord-003302-vxk7uqlc	292	35	a	a	DT
cord-003302-vxk7uqlc	292	36	healthy	healthy	JJ
cord-003302-vxk7uqlc	292	37	volunteer	volunteer	NN
cord-003302-vxk7uqlc	292	38	challenge	challenge	NN
cord-003302-vxk7uqlc	292	39	with	with	IN
cord-003302-vxk7uqlc	292	40	influenza	influenza	NN
cord-003302-vxk7uqlc	292	41	A	A	NNP
cord-003302-vxk7uqlc	292	42	/	/	SYM
cord-003302-vxk7uqlc	292	43	H1N1pdm	H1N1pdm	NNP
cord-003302-vxk7uqlc	292	44	virus	virus	NN
cord-003302-vxk7uqlc	293	1	M	M	NNP
cord-003302-vxk7uqlc	294	1	The	the	DT
cord-003302-vxk7uqlc	294	2	pandemic	pandemic	NN
cord-003302-vxk7uqlc	294	3	influenza	influenza	NN
cord-003302-vxk7uqlc	294	4	preparedness	preparedness	NN
cord-003302-vxk7uqlc	294	5	framework	framework	NN
cord-003302-vxk7uqlc	294	6	:	:	:
cord-003302-vxk7uqlc	294	7	a	a	DT
cord-003302-vxk7uqlc	294	8	visible	visible	JJ
cord-003302-vxk7uqlc	294	9	procurement	procurement	NN
cord-003302-vxk7uqlc	294	10	option	option	NN
cord-003302-vxk7uqlc	294	11	for	for	IN
cord-003302-vxk7uqlc	294	12	developing	develop	VBG
cord-003302-vxk7uqlc	294	13	states	state	NNS
cord-003302-vxk7uqlc	294	14	?	?	.
cord-003302-vxk7uqlc	295	1	Epidemiology	epidemiology	NN
cord-003302-vxk7uqlc	295	2	of	of	IN
cord-003302-vxk7uqlc	295	3	avian	avian	JJ
cord-003302-vxk7uqlc	295	4	influenza	influenza	NN
cord-003302-vxk7uqlc	295	5	A	a	DT
cord-003302-vxk7uqlc	295	6	H7N9	H7N9	NNP
cord-003302-vxk7uqlc	295	7	virus	virus	NN
cord-003302-vxk7uqlc	295	8	in	in	IN
cord-003302-vxk7uqlc	295	9	human	human	JJ
cord-003302-vxk7uqlc	295	10	beings	being	NNS
cord-003302-vxk7uqlc	295	11	across	across	IN
cord-003302-vxk7uqlc	295	12	five	five	CD
cord-003302-vxk7uqlc	295	13	epidemics	epidemic	NNS
cord-003302-vxk7uqlc	295	14	in	in	IN
cord-003302-vxk7uqlc	295	15	mainland	mainland	NN
cord-003302-vxk7uqlc	295	16	China	China	NNP
cord-003302-vxk7uqlc	295	17	,	,	,
cord-003302-vxk7uqlc	295	18	2013	2013	CD
cord-003302-vxk7uqlc	295	19	-	-	SYM
cord-003302-vxk7uqlc	295	20	17	17	CD
cord-003302-vxk7uqlc	295	21	:	:	:
cord-003302-vxk7uqlc	295	22	an	an	DT
cord-003302-vxk7uqlc	295	23	epidemiological	epidemiological	JJ
cord-003302-vxk7uqlc	295	24	study	study	NN
cord-003302-vxk7uqlc	295	25	of	of	IN
cord-003302-vxk7uqlc	295	26	laboratory	laboratory	NN
cord-003302-vxk7uqlc	295	27	-	-	HYPH
cord-003302-vxk7uqlc	295	28	confirmed	confirm	VBN
cord-003302-vxk7uqlc	295	29	case	case	NN
cord-003302-vxk7uqlc	295	30	series	series	NN
cord-003302-vxk7uqlc	295	31	Statins	Statins	NNPS
cord-003302-vxk7uqlc	295	32	,	,	,
cord-003302-vxk7uqlc	295	33	influenza	influenza	NN
cord-003302-vxk7uqlc	295	34	vaccination	vaccination	NN
cord-003302-vxk7uqlc	295	35	and	and	CC
cord-003302-vxk7uqlc	295	36	influenza	influenza	NN
cord-003302-vxk7uqlc	295	37	The	the	DT
cord-003302-vxk7uqlc	295	38	role	role	NN
cord-003302-vxk7uqlc	295	39	of	of	IN
cord-003302-vxk7uqlc	295	40	adjuvant	adjuvant	JJ
cord-003302-vxk7uqlc	295	41	immunomodulatory	immunomodulatory	JJ
cord-003302-vxk7uqlc	295	42	agents	agent	NNS
cord-003302-vxk7uqlc	295	43	for	for	IN
cord-003302-vxk7uqlc	295	44	treatment	treatment	NN
cord-003302-vxk7uqlc	295	45	of	of	IN
cord-003302-vxk7uqlc	295	46	severe	severe	JJ
cord-003302-vxk7uqlc	295	47	influenza	influenza	NN
cord-003302-vxk7uqlc	295	48	Darwin	Darwin	NNP
cord-003302-vxk7uqlc	295	49	and	and	CC
cord-003302-vxk7uqlc	295	50	the	the	DT
cord-003302-vxk7uqlc	295	51	scientific	scientific	JJ
cord-003302-vxk7uqlc	295	52	method	method	NN
cord-003302-vxk7uqlc	295	53	Influenza	Influenza	NNP
cord-003302-vxk7uqlc	295	54	in	in	IN
cord-003302-vxk7uqlc	295	55	1918	1918	CD
cord-003302-vxk7uqlc	295	56	:	:	:
cord-003302-vxk7uqlc	295	57	recollections	recollection	NNS
cord-003302-vxk7uqlc	295	58	of	of	IN
cord-003302-vxk7uqlc	295	59	the	the	DT
cord-003302-vxk7uqlc	295	60	epidemic	epidemic	NN
cord-003302-vxk7uqlc	295	61	in	in	IN
cord-003302-vxk7uqlc	295	62	Philadelphia	Philadelphia	NNP
cord-003302-vxk7uqlc	295	63	Herding	Herding	NNP
cord-003302-vxk7uqlc	295	64	,	,	,
cord-003302-vxk7uqlc	295	65	social	social	JJ
cord-003302-vxk7uqlc	295	66	influences	influence	NNS
cord-003302-vxk7uqlc	295	67	and	and	CC
cord-003302-vxk7uqlc	295	68	behavioural	behavioural	JJ
cord-003302-vxk7uqlc	295	69	bias	bias	NN
cord-003302-vxk7uqlc	295	70	in	in	IN
cord-003302-vxk7uqlc	295	71	scientific	scientific	JJ
cord-003302-vxk7uqlc	295	72	research	research	NN
cord-003302-vxk7uqlc	295	73	:	:	:
cord-003302-vxk7uqlc	295	74	Simple	simple	JJ
cord-003302-vxk7uqlc	295	75	awareness	awareness	NN
cord-003302-vxk7uqlc	295	76	of	of	IN
cord-003302-vxk7uqlc	295	77	the	the	DT
cord-003302-vxk7uqlc	295	78	hidden	hide	VBN
cord-003302-vxk7uqlc	295	79	pressures	pressure	NNS
cord-003302-vxk7uqlc	295	80	and	and	CC
cord-003302-vxk7uqlc	295	81	beliefs	belief	NNS
cord-003302-vxk7uqlc	295	82	that	that	WDT
cord-003302-vxk7uqlc	295	83	influence	influence	VBP
cord-003302-vxk7uqlc	295	84	our	-PRON-	PRP$
cord-003302-vxk7uqlc	295	85	thinking	thinking	NN
cord-003302-vxk7uqlc	295	86	can	can	MD
cord-003302-vxk7uqlc	295	87	help	help	VB
cord-003302-vxk7uqlc	295	88	to	to	TO
cord-003302-vxk7uqlc	295	89	preserve	preserve	VB
cord-003302-vxk7uqlc	295	90	objectivity	objectivity	NN
cord-003302-vxk7uqlc	295	91	Revolutionary	revolutionary	JJ
cord-003302-vxk7uqlc	295	92	science	science	NN