id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011757-11r3dnse	van Wijhe, Maarten	Loose Ends in the Epidemiology of the 1918 Pandemic: Explaining the Extreme Mortality Risk in Young Adults	2018-09-06		.txt	text/plain	4372	225	55	We address the hypothesis of "original antigenic sin" (1)-that early childhood exposure may determine death risk during influenza pandemics encountered later in life-which may explain why some age cohorts fared differently in this pandemic. This hypothesis has brewed for some time (2) , and detailed analyses of 1918 data from Kentucky (3) as well as analysis of the dramatically different age patterns among victims of avian H5N1 and H7N9 influenza who were born before and after the 1968 pandemic (4-6) have brought new steam to this old question. To further investigate the age-related patterns of death rates and risk change points in 1918, we analyzed monthly all-cause and age-stratified mortality data from Copenhagen to address the antigenic sin hypothesis. So far, the observation that adults older than 45 years suffered no excess mortality in cities like New York City and in Copenhagen has been interpreted as evidence of "recycling" of the H1 antigen that age group had encountered during their childhood some 50 years earlier (18, 20) .	./cache/cord-011757-11r3dnse.txt	./txt/cord-011757-11r3dnse.txt