id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261733-kc0d5pe8	Galili, Uri	Why Do We Produce Anti-Gal: Evolutionary Appearance of Anti-Gal in Old World Primates	2017-09-15		.txt	text/plain	9396	411	43	A present day example of a scenario in which a glycosyltransferase gene is inactivated in small human populations, and the resulting production of a natural antibody against the eliminated carbohydrate antigen is the blood group "Bombay" individuals, discussed at the end of this chapter. Epidemics by enveloped viruses presenting α-gal epitopes that were synthesized by α1,3GT of ancestral Old World primates caused the extinction of these primates, whereas offspring-lacking α-gal epitopes were protected by the natural anti-Gal antibody they produced. The antibody is unique to humans, apes, and Old World monkeys, and it binds specifically to a mammalian carbohydrate antigen called the α-gal epitope that is synthesized in nonprimate mammals, lemurs (prosimians) and New World monkeys by the glycosylation enzyme α1,3GT. The antibody is unique to humans, apes, and Old World monkeys, and it binds specifically to a mammalian carbohydrate antigen called the α-gal epitope that is synthesized in nonprimate mammals, lemurs (prosimians) and New World monkeys by the glycosylation enzyme α1,3GT.	./cache/cord-261733-kc0d5pe8.txt	./txt/cord-261733-kc0d5pe8.txt